Tongtong Xu, Xiaoming Yang, Changyue Wu, Jiaying Qiu, Qingqing Fang, Lingbin Wang, Shu Yu, Hualin Sun
BACKGROUND: Cachexia, a wasting syndrome, is most commonly observed in individuals with advanced cancer including lung cancer, esophageal cancer, liver cancer, etc. The characteristic sign of cachexia is muscle atrophy. To date, effective countermeasures have been still deficiency to alleviate muscle atrophy. Reactive oxygen species (ROS) are important regulators of muscle atrophy. Therefore, the effects of a naturally antioxidant, pyrroloquinoline quinone (PQQ), were explored on muscle atrophy induced by cachexia in the present study...
May 2018: Journal of Thoracic Disease