keyword
https://read.qxmd.com/read/37329547/effects-of-pyrroloquinoline-quinone-pqq-and-coenzyme-q10-on-mitochondrial-genes-mitomirs-and-cellular-properties-in-hepg2-cell-line
#1
JOURNAL ARTICLE
Muhammed Ali Nalbant, Onur Eroğlu
Our study aimed to reveal the effects and changes, antioxidant metabolism (Oxidative Stress), inflammatory response, mitochondrial biogenesis and mitochondrial dysfunction characteristics in hepatocellular carcinoma cell line HepG2; that occur in genes (NRF-1, NRF-2, NFκB and PGC-1α) and miRNAs (miR15-a, miR16-1, miR181-c) that can control related features. To investigate the effects of Pyrroloquinoline quinone (PQQ) and Coenzyme Q10 (CoQ10) in HepG2, and their effects on cell viability, lateral cell migration, gene expression and miRNA expression levels were investigated...
April 30, 2023: Cellular and Molecular Biology
https://read.qxmd.com/read/35340329/pqq-dietary-supplementation-prevents-alkylating-agent-induced-ovarian-dysfunction-in-mice
#2
JOURNAL ARTICLE
Xiuliang Dai, Xiangjiao Yi, Yufeng Wang, Wei Xia, Jianguo Tao, Jun Wu, Dengshun Miao, Li Chen
Alkylating agents (AAs) that are commonly used for cancer therapy cause great damage to the ovary. Pyrroloquinoline-quinine (PQQ), which was initially identified as a redox cofactor for bacterial dehydrogenases, has been demonstrated to benefit the fertility of females. The aim of this study was to investigate whether PQQ dietary supplementation plays a protective role against alkylating agent-induced ovarian dysfunction. A single dose of busulphan (20 mg/kg) and cyclophosphamide (CTX, 120 mg/kg) were used to establish a mouse model of ovarian dysfunction...
2022: Frontiers in Endocrinology
https://read.qxmd.com/read/34759737/pyrroloquinoline-quinone-alleviates-oxidative-damage-induced-by-high-glucose-in-hepg2-cells
#3
JOURNAL ARTICLE
Saad Alkahtani, Saud Alarifi, Abdullah A Alkahtane, Gadah Albasher, Mohammed Al-Zharani, Norah M Alhoshani, Norah S Al-Johani, Nada H Aljarba, Md Saquib Hasnain
Hyperglycemia as a common metabolic disorder in diabetes led to oxidative stress, inflammation and other complications. Natural and manufactured antioxidants alleviates the side effects of diabetes. The purpose of current study is to investigate the effect of pyrroloquinoline quinine (PQQ) as an antioxidant on the content of glucose-induced oxidative stress generation in the cells of the human hepatocellular liver carcinoma (HepG2) by inhibiting advanced glycation end products (AGEs) formation. The HepG2 cells were exposed to high dose (50 mM) of glucose (HG) only and with PQQ (HG + PQQ)...
November 2021: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/33288426/an-amperometric-biosensor-of-l-fucose-in-urine-for-the-first-screening-test-of-cancer
#4
JOURNAL ARTICLE
Kouta Takeda, Ryo Kusuoka, Misaki Inukai, Kiyohiko Igarashi, Hiroyuki Ohno, Nobuhumi Nakamura
Quantitative routine detection of fucose, which is a cancer marker, in urine is effective for the preliminary screening of cancer. Amperometric biosensing methods have the advantage of being simple, rapid, and precise for urinalysis. However, coexisting electroactive interferences such as ascorbic acid (AA), dopamine (DA), and uric acid (UA) prevent accurate measurements. In this work, an amperometric l-fucose biosensor unaffected by interferences was developed and utilizes direct electron transfer type bioelectrocatalysis of pyrroloquinoline quinone (PQQ)-dependent pyranose dehydrogenase from Coprinopsis cinerea (CcPDH)...
February 15, 2021: Biosensors & Bioelectronics
https://read.qxmd.com/read/30015942/apoptotic-effect-of-pyrroloquinoline-quinone-on-chondrosarcoma-cells-through-activation-of-the-mitochondrial-caspase%C3%A2-dependent-and-caspase%C3%A2-independent-pathways
#5
JOURNAL ARTICLE
Ronghuan Wu, Jun Pan, Miaoda Shen, Chunyang Xing
Chondrosarcomas are malignant tumors of the bone that exhibit resistance to chemotherapy and radiation. Pyrroloquinoline quinone (PQQ) is a bacterial redox co‑factor and antioxidant that has been found to induce apoptosis in various cancer cells. This study investigated the role of PQQ in cell apoptosis of chondrosarcoma cells and the underlying pathways involved. We confirmed that PQQ was cytotoxic to chondrosarcoma SW1353 cells by a cell cytotoxicity assay. Furthermore, flow cytometry showed that the number of apoptotic cells increased in a concentration‑dependent and time‑dependent manner following PQQ treatment, but this effect was not significant in normal cells...
September 2018: Oncology Reports
https://read.qxmd.com/read/29997937/pyrroloquinoline-quinone-attenuates-cachexia-induced-muscle-atrophy-via-suppression-of-reactive-oxygen-species
#6
JOURNAL ARTICLE
Tongtong Xu, Xiaoming Yang, Changyue Wu, Jiaying Qiu, Qingqing Fang, Lingbin Wang, Shu Yu, Hualin Sun
BACKGROUND: Cachexia, a wasting syndrome, is most commonly observed in individuals with advanced cancer including lung cancer, esophageal cancer, liver cancer, etc. The characteristic sign of cachexia is muscle atrophy. To date, effective countermeasures have been still deficiency to alleviate muscle atrophy. Reactive oxygen species (ROS) are important regulators of muscle atrophy. Therefore, the effects of a naturally antioxidant, pyrroloquinoline quinone (PQQ), were explored on muscle atrophy induced by cachexia in the present study...
May 2018: Journal of Thoracic Disease
https://read.qxmd.com/read/29568949/pyrroloquinoline-quinone-induces-chondrosarcoma-cell-apoptosis-by-increasing-intracellular-reactive-oxygen-species
#7
JOURNAL ARTICLE
Linchun Wen, Xiyan Lu, Rui Wang, Xiaowei Jin, Liqiang Hu, Chuanwen You
Pyrroloquinoline quinone (PQQ) has been reported to contribute to cancer cell apoptosis and death; however, little is known of its underlying mechanisms. The present study was designed to investigate the role of PQQ in chondrosarcoma cell apoptosis and the underlying mechanism. A cell cytotoxicity assay was used to detect cell death; flow cytometry analysis was also performed to determine cell apoptosis and intracellular reactive oxygen species (ROS). Biochemical methods were employed to detect the activity and the expression of superoxide dismutase (SOD)1, SOD2 and glutathione...
May 2018: Molecular Medicine Reports
https://read.qxmd.com/read/28883836/the-effect-of-pyrroloquinoline-quinone-on-the-expression-of-wisp1-in-traumatic-brain-injury
#8
JOURNAL ARTICLE
Yongqi Ye, Pengju Zhang, Yuhang Qian, Baoxin Yin, Meijuan Yan
WISP1, as a member of the CCN4 protein family, has cell protective effects of promoting cell proliferation and inhibiting cell apoptosis. Although some studies have confirmed that WISP1 is concerned with colon cancer and lung cancer, there is little report about the influence of WISP1 in traumatic brain injury. Here, we found that the expression of WISP1 mRNA and protein decreased at 3 d and then increased at 5 d after traumatic brain injury (TBI). Meanwhile, immunofluorescence demonstrated that there was little colocation of WISP1 with GFAP, Iba1, and WISP1 colocalized with NeuN partly...
2017: Stem Cells International
https://read.qxmd.com/read/26224906/preparation-of-99m-tc-pqq-and-preliminary-biological-evaluation-for-the-nmda-receptor
#9
JOURNAL ARTICLE
Yanyan Kong, Xingqin Zhou, Guoxian Cao, Xijie Xu, Meifen Zou, Xiaofeng Qin, Rongjun Zhang
Pyrroloquinoline quinone (PQQ), an essential nutrient, antioxidant, redox modulator and nerve growth factor found in a class of enzymes called quinoproteins, was labeled with 99m Tc by using stannous fluoride (SnF2 ) method. Radiolabeling qualification, quality control and characterization of 99m Tc-PQQ and its biodistribution studies in mice were performed and discussed. Effects of pH values, temperature, time and reducing agents concentration on the radiolabeling yield were investigated. The quality control procedure of 99m Tc-PQQ was determined by thin layer chromatography (TLC), radio high-performance liquid chromatography (RHPLC) and paper electrophoresis methods...
2011: Journal of Radioanalytical and Nuclear Chemistry
https://read.qxmd.com/read/25832358/a-novel-quinoline-based-second-generation-mtor-inhibitor-that-induces-apoptosis-and-disrupts-pi3k-akt-mtor-signaling-in-human-leukemia-hl-60-cells
#10
JOURNAL ARTICLE
Suresh Kumar, Santosh Kumar Guru, Vunnam Venkateswarlu, Fayaz Malik, Ram A Vishwakarma, Sanghapal D Sawant, Shashi Bhushan
Deregulation of the PI3K-Akt-mTOR pathway is unanimously pragmatic in a number of tumors. This pathway pedals proliferation, survival, translation, and coupled with tumor-associated endurance. Current efforts focus on the discovery and development of novel inhibitors of this pathway. We have discovered 6-(4-phenoxyphenyl)-N-phenylquinolin-4-amine [PQQ] as a potent mTOR inhibitor with IC50 value of 64nM in a cell-based and cell-free mTOR assay. Mechanistically, PQQ was found to be a strong PI3K-Akt-mTOR-p70S6K cascade inhibitor in Human promyelocytic leukemia HL-60 cells...
2015: Anti-cancer Agents in Medicinal Chemistry
https://read.qxmd.com/read/25161699/pyrroloquinoline-quinone-induces-cancer-cell-apoptosis-via-mitochondrial-dependent-pathway-and-down-regulating-cellular-bcl-2-protein-expression
#11
JOURNAL ARTICLE
Zhihui Min, Lingyan Wang, Jianjun Jin, Xiangdong Wang, Bijun Zhu, Hao Chen, Yunfeng Cheng
Pyrroloquinoline quinone (PQQ) has been reported as a promising agent that might contribute to tumor cell apoptosis and death, yet little is known on its mechanisms. In current study, the effect of PQQ on cell proliferation and mitochondrial-dependent apoptosis were examined in 3 solid tumor cell lines (A549, Neuro-2A and HCC-LM3). PQQ treatment at low to medium dosage exhibited potent anti-tumor activity on A549 and Neuro-2A cells, while had comparably minimal impact on the viabilities of 2 human normal cell lines (HRPTEpiC and HUVEC)...
2014: Journal of Cancer
https://read.qxmd.com/read/24996136/design-synthesis-and-antiproliferative-activity-of-a-novel-class-of-indole-2-carboxylate-derivatives
#12
JOURNAL ARTICLE
Xing-yue Ji, Si-tu Xue, Yue-chen Zhan, Jia-jia Shen, Lin-tao Wu, Jie Jin, Zhen Wang, Zhuo-rong Li
Based on the chemical structure of Pyrroloquinoline quinone (PQQ), a novel class of indole-2-carboxylate derivatives was designed, synthesized and assayed for antiproliferative activity in cancer cells in vitro. The biological results showed that some derivatives exhibited significant antiproliferative activity against HepG2, A549 and MCF7 cells. Notably, the novel compounds, methyl 6-amino-4-cyclohexylmethoxy-1H-indole-2-carboxylate (6e) and methyl 4-isopropoxy-6-methoxy-1H-indole-2-carboxylate (9l) exhibited more potent antiproliferative activity than the reference drugs PQQ and etoposide in vitro, with IC50 values ranging from 3...
August 18, 2014: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/17071070/integrated-nanoparticle-biomolecule-systems-for-biosensing-and-bioelectronics
#13
REVIEW
Itamar Willner, Ronan Baron, Bilha Willner
The similar dimensions of biomolecules such as enzymes, antibodies or DNA, and metallic or semiconductor nanoparticles (NPs) enable the synthesis of biomolecule-NP hybrid systems where the unique electronic, photonic and catalytic properties of NPs are combined with the specific recognition and biocatalytic properties of biomolecules. The unique functions of biomolecule-NP hybrid systems are discussed with several examples: (i) the electrical contacting of redox enzymes with electrodes is the basis for the development of enzymatic electrodes for amperometric biosensors or biofuel cell elements...
April 15, 2007: Biosensors & Bioelectronics
https://read.qxmd.com/read/16750941/biomolecule-nanoparticle-hybrid-systems-for-bioelectronic-applications
#14
REVIEW
Itamar Willner, Bilha Willner, Eugenii Katz
Recent advances in nanobiotechnology involve the use of biomolecule-nanoparticle (NP) hybrid systems for bioelectronic applications. This is exemplified by the electrical contacting of redox enzymes by means of Au-NPs. The enzymes, glucose oxidase, GOx, and glucose dehydrogenase, GDH, are electrically contacted with the electrodes by the reconstitution of the corresponding apo-proteins on flavin adenine dinucleotide (FAD) or pyrroloquinoline quinone (PQQ)-functionalized Au-NPs (1.4 nm) associated with electrodes, respectively...
January 2007: Bioelectrochemistry
https://read.qxmd.com/read/7770184/the-role-of-phenolics-conjugated-linoleic-acid-carnosine-and-pyrroloquinoline-quinone-as-nonessential-dietary-antioxidants
#15
REVIEW
E A Decker
Oxidative reactions have been implicated in the development of numerous diseases including atherosclerosis and cancer. Oxidation of lipids, proteins, and nucleic acids can result in loss of membrane integrity and function, inactivation of enzymes, modification of lipoproteins, and chemical alteration of DNA. Active oxygen species, transition metals, reducing agents, and enzymes such as lipoxygenase are all involved in the catalysis of oxidative reactions. Since lipid oxidation catalysts and active oxygen species are ubiquitous to all biological systems and since lipid oxidation products can enter the body via oxidized foods, numerous endogenous antioxidant systems have been developed...
March 1995: Nutrition Reviews
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