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PQQ AND Cancer

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https://www.readbyqxmd.com/read/26224906/preparation-of-99m-tc-pqq-and-preliminary-biological-evaluation-for-the-nmda-receptor
#1
Yanyan Kong, Xingqin Zhou, Guoxian Cao, Xijie Xu, Meifen Zou, Xiaofeng Qin, Rongjun Zhang
Pyrroloquinoline quinone (PQQ), an essential nutrient, antioxidant, redox modulator and nerve growth factor found in a class of enzymes called quinoproteins, was labeled with (99m)Tc by using stannous fluoride (SnF2) method. Radiolabeling qualification, quality control and characterization of (99m)Tc-PQQ and its biodistribution studies in mice were performed and discussed. Effects of pH values, temperature, time and reducing agents concentration on the radiolabeling yield were investigated. The quality control procedure of (99m)Tc-PQQ was determined by thin layer chromatography (TLC), radio high-performance liquid chromatography (RHPLC) and paper electrophoresis methods...
2011: Journal of Radioanalytical and Nuclear Chemistry
https://www.readbyqxmd.com/read/25832358/a-novel-quinoline-based-second-generation-mtor-inhibitor-that-induces-apoptosis-and-disrupts-pi3k-akt-mtor-signaling-in-human-leukemia-hl-60-cells
#2
Suresh Kumar, Santosh Kumar Guru, Vunnam Venkateswarlu, Fayaz Malik, Ram A Vishwakarma, Sanghapal D Sawant, Shashi Bhushan
Deregulation of the PI3K-Akt-mTOR pathway is unanimously pragmatic in a number of tumors. This pathway pedals proliferation, survival, translation, and coupled with tumor-associated endurance. Current efforts focus on the discovery and development of novel inhibitors of this pathway. We have discovered 6-(4-phenoxyphenyl)-N-phenylquinolin-4-amine [PQQ] as a potent mTOR inhibitor with IC50 value of 64nM in a cell-based and cell-free mTOR assay. Mechanistically, PQQ was found to be a strong PI3K-Akt-mTOR-p70S6K cascade inhibitor in Human promyelocytic leukemia HL-60 cells...
2015: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/25161699/pyrroloquinoline-quinone-induces-cancer-cell-apoptosis-via-mitochondrial-dependent-pathway-and-down-regulating-cellular-bcl-2-protein-expression
#3
Zhihui Min, Lingyan Wang, Jianjun Jin, Xiangdong Wang, Bijun Zhu, Hao Chen, Yunfeng Cheng
Pyrroloquinoline quinone (PQQ) has been reported as a promising agent that might contribute to tumor cell apoptosis and death, yet little is known on its mechanisms. In current study, the effect of PQQ on cell proliferation and mitochondrial-dependent apoptosis were examined in 3 solid tumor cell lines (A549, Neuro-2A and HCC-LM3). PQQ treatment at low to medium dosage exhibited potent anti-tumor activity on A549 and Neuro-2A cells, while had comparably minimal impact on the viabilities of 2 human normal cell lines (HRPTEpiC and HUVEC)...
2014: Journal of Cancer
https://www.readbyqxmd.com/read/24996136/design-synthesis-and-antiproliferative-activity-of-a-novel-class-of-indole-2-carboxylate-derivatives
#4
Xing-yue Ji, Si-tu Xue, Yue-chen Zhan, Jia-jia Shen, Lin-tao Wu, Jie Jin, Zhen Wang, Zhuo-rong Li
Based on the chemical structure of Pyrroloquinoline quinone (PQQ), a novel class of indole-2-carboxylate derivatives was designed, synthesized and assayed for antiproliferative activity in cancer cells in vitro. The biological results showed that some derivatives exhibited significant antiproliferative activity against HepG2, A549 and MCF7 cells. Notably, the novel compounds, methyl 6-amino-4-cyclohexylmethoxy-1H-indole-2-carboxylate (6e) and methyl 4-isopropoxy-6-methoxy-1H-indole-2-carboxylate (9l) exhibited more potent antiproliferative activity than the reference drugs PQQ and etoposide in vitro, with IC50 values ranging from 3...
August 18, 2014: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/17071070/integrated-nanoparticle-biomolecule-systems-for-biosensing-and-bioelectronics
#5
REVIEW
Itamar Willner, Ronan Baron, Bilha Willner
The similar dimensions of biomolecules such as enzymes, antibodies or DNA, and metallic or semiconductor nanoparticles (NPs) enable the synthesis of biomolecule-NP hybrid systems where the unique electronic, photonic and catalytic properties of NPs are combined with the specific recognition and biocatalytic properties of biomolecules. The unique functions of biomolecule-NP hybrid systems are discussed with several examples: (i) the electrical contacting of redox enzymes with electrodes is the basis for the development of enzymatic electrodes for amperometric biosensors or biofuel cell elements...
April 15, 2007: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/16750941/biomolecule-nanoparticle-hybrid-systems-for-bioelectronic-applications
#6
REVIEW
Itamar Willner, Bilha Willner, Eugenii Katz
Recent advances in nanobiotechnology involve the use of biomolecule-nanoparticle (NP) hybrid systems for bioelectronic applications. This is exemplified by the electrical contacting of redox enzymes by means of Au-NPs. The enzymes, glucose oxidase, GOx, and glucose dehydrogenase, GDH, are electrically contacted with the electrodes by the reconstitution of the corresponding apo-proteins on flavin adenine dinucleotide (FAD) or pyrroloquinoline quinone (PQQ)-functionalized Au-NPs (1.4 nm) associated with electrodes, respectively...
January 2007: Bioelectrochemistry
https://www.readbyqxmd.com/read/7770184/the-role-of-phenolics-conjugated-linoleic-acid-carnosine-and-pyrroloquinoline-quinone-as-nonessential-dietary-antioxidants
#7
REVIEW
E A Decker
Oxidative reactions have been implicated in the development of numerous diseases including atherosclerosis and cancer. Oxidation of lipids, proteins, and nucleic acids can result in loss of membrane integrity and function, inactivation of enzymes, modification of lipoproteins, and chemical alteration of DNA. Active oxygen species, transition metals, reducing agents, and enzymes such as lipoxygenase are all involved in the catalysis of oxidative reactions. Since lipid oxidation catalysts and active oxygen species are ubiquitous to all biological systems and since lipid oxidation products can enter the body via oxidized foods, numerous endogenous antioxidant systems have been developed...
March 1995: Nutrition Reviews
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