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https://www.readbyqxmd.com/read/28550801/the-nk-1-receptor-antagonist-l-732-138-induces-apoptosis-in-human-gastrointestinal-cancer-cell-lines
#1
Miguel Muñoz, Marisa Rosso, Rafael Coveñas
BACKGROUND: Gastric and colon cancer cells express the neurokinin-1 receptor (NK-1R) and the peptide substance P (SP), after binding to this receptor, elicits the proliferation of gastrointestinal cancer cells and an antiapoptotic effect. In these cells, NK-1R antagonists (L-733,060: a piperidine derivative; aprepitant: a morpholine derivative) block, after binding to the NK-1R, the action of SP and exert an antiproliferative action, both antagonists promote apoptosis and the death of cancer cells...
February 12, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28550755/sedentary-behaviour-patterns-in-outpatients-with-severe-mental-illness-a-cross-sectional-study-using-objective-and-self-reported-methods-the-psychiactive-project
#2
Javier Bueno-Antequera, Miguel Ángel Oviedo-Caro, Diego Munguia-Izquierdo
This study aimed to quantify and compare sedentary behaviour patterns in patients with severe mental illness as stratified by gender, age, body mass index, distress, illness duration and antipsychotic medication using both objective and self-reported methods. Sedentary behaviour patterns were measured in 90 outpatients (mean age±SD: 41.6±9.2 years, 20% women) with severe mental illness (primarily schizophrenia, n=63) using the SenseWear Armband and the Sedentary Behaviour Questionnaire. They spent 58% of waking time sedentary, primarily watching television...
May 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28550677/mineral-profile-of-children-s-fast-food-menu-samples
#3
Maria Luisa Cervera, Miguel de la Guardia, Manuela Ruiz-de-Cenzano, Arancha Rochina-Marco, Óscar López-Salazar
Children's fast food menus, including hamburgers served with french fries, dessert, and a soft drink, were analyzed to obtain the mineral profile of trace elements. The developed analytical methodology involved sample digestion under pressure inside a microwave oven with a mixture of HNO₃ and H₂O₂ and inductively coupled plasma-optical emission spectrometry. The method was validated by carrying out the analysis of certified reference materials (NIST 1570a spinach leaves, NCS ZC73016 chicken, and NIST 1568a rice flour) and using recovery experiments...
May 26, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28550647/genetic-variation-in-the-adipoq-gene-adiponectin-concentrations-and-risk-of-colorectal-cancer-a-mendelian-randomization-analysis-using-data-from-three-large-cohort-studies
#4
Katharina Nimptsch, Mingyang Song, Krasimira Aleksandrova, Michail Katsoulis, Heinz Freisling, Mazda Jenab, Marc J Gunter, Konstantinos K Tsilidis, Elisabete Weiderpass, H Bas Bueno-De-Mesquita, Dawn Q Chong, Majken K Jensen, Chunsen Wu, Kim Overvad, Tilman Kühn, Myrto Barrdahl, Olle Melander, Karin Jirström, Petra H Peeters, Sabina Sieri, Salvatore Panico, Amanda J Cross, Elio Riboli, Bethany Van Guelpen, Robin Myte, José María Huerta, Miguel Rodriguez-Barranco, José Ramón Quirós, Miren Dorronsoro, Anne Tjønneland, Anja Olsen, Ruth Travis, Marie-Christine Boutron-Ruault, Franck Carbonnel, Gianluca Severi, Catalina Bonet, Domenico Palli, Jürgen Janke, Young-Ae Lee, Heiner Boeing, Edward L Giovannucci, Shuji Ogino, Charles S Fuchs, Eric Rimm, Kana Wu, Andrew T Chan, Tobias Pischon
Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses' Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the ADIPOQ gene...
May 26, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28550532/drug-induced-hsp90-inhibition-alleviates-pain-in-monoarthritic-rats-and-alters-the-expression-of-new-putative-pain-players-at-the-drg
#5
Diana Sofia Marques Nascimento, Catarina Soares Potes, Miguel Luz Soares, António Carlos Ferreira, Marzia Malcangio, José Manuel Castro-Lopes, Fani Lourença Moreira Neto
Purinergic receptors (P2XRs) have been widely associated with pain states mostly due to their involvement in neuron-glia communication. Interestingly, we have previously shown that satellite glial cells (SGC), surrounding dorsal root ganglia (DRG) neurons, become activated and proliferate during monoarthritis (MA) in the rat. Here, we demonstrate that P2X7R expression increases in ipsilateral DRG after 1 week of disease, while P2X3R immunoreactivity decreases. We have also reported a significant induction of the activating transcriptional factor 3 (ATF3) in MA...
May 26, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28550254/precuneus-failures-in-subjects-of-the-psen1-e280a-family-at-risk-of-developing-alzheimer-s-disease-detected-using-quantitative-electroencephalography
#6
John Fredy Ochoa, Joan Francesc Alonso, Jon Edinson Duque, Carlos Andrés Tobón, Ana Baena, Francisco Lopera, Miguel Angel Mañanas, Alher Mauricio Hernández
BACKGROUND: Presenilin-1 (PSEN1) mutations are the most common cause of familial early onset Alzheimer's disease (AD). The PSEN1 E280A (E280A) mutation has an autosomal dominant inheritance and is involved in the production of amyloid-β. The largest family group of carriers with E280A mutation is found in Antioquia, Colombia. The study of mutation carriers provides a unique opportunity to identify brain changes in stages previous to AD. Electroencephalography (EEG) is a low cost and minimally invasiveness technique that enables the following of brain changes in AD...
May 26, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28550086/the-iron-dependent-mitochondrial-superoxide-dismutase-soda-promotes-leishmania-virulence
#7
Bidyottam Mittra, Maria Fernanda Laranjeira-Silva, Danilo Ciccone Miguel, Juliana Perrone Bezerra de Menezes, Norma W Andrews
Leishmaniasis is one of the leading global neglected diseases, affecting millions of people worldwide. Leishmania infection depends on the ability of insect-transmitted metacyclic promastigotes to invade mammalian hosts, differentiate into amastigotes and replicate inside macrophages. To counter the hostile oxidative environment inside macrophages, these protozoans contain anti-oxidant systems that include iron-dependent superoxide dismutases (SODs) in mitochondria and glycosomes. Increasing evidence suggests that in addition to this protective role, Leishmania mitochondrial SOD may also initiate H2O2-mediated redox signaling that regulates gene expression and metabolic changes associated with differentiation into virulent forms...
May 26, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28549945/validity-of-the-rheumatoid-arthritis-impact-of-disease-raid-score-and-definition-of-cut-off-points-for-disease-activity-states-in-a-population-based-european-cohort-of-patients-with-rheumatoid-arthritis
#8
Fausto Salaffi, Marco Di Carlo, Jelena Vojinovic, Angela Tincani, Alberto Sulli, Stefano Soldano, Laura Andreoli, Francesca Dall'Ara, Ruxandra Ionescu, Katarina Simić Pašalić, Ineta Balčune, Iván Ferraz-Amaro, Malgorzata Tlustochowicz, Irena Butrimienė, Egle Punceviciene, Natalia Toroptsova, Simeon Grazio, Jadranka Morović-Vergles, Pavol Masaryk, Kati Otsa, Miguel Bernardes, Vladimira Boyadzhieva, Maurizio Cutolo
OBJECTIVES: To assess the validity of the Rheumatoid Arthritis Impact of Disease (RAID) for measuring disease activity of rheumatoid arthritis (RA), and to determine cut-off values for defining the disease activity states. METHODS: 622 RA patients from an European database have been included. Cross-validation was based on assessment of convergent and discriminant validity. Optimal cut-offs were determined against external criteria by calculating the respective 25(th) and 75(th) percentiles mean values of RAID...
May 23, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28549731/clinical-and-sonographic-biomarkers-of-structural-damage-progression-in-ra-patients-in-clinical-remission-a-prospective-study-with-12-months-follow-up
#9
Julio Ramírez, José Antonio Narváez, Virginia Ruiz-Esquide, Javier Hernández-Gañán, Andrea Cuervo, José Inciarte-Mundo, Maria Victoria Hernández, Miguel Sampayo-Cordero, José Luis Pablos, Raimon Sanmartí, Juan D Cañete
OBJECTIVE: To determine clinical and sonographic biomarkers predicting structural damage progression at 12 months of follow-up as measured by magnetic resonance imaging (MRI) in rheumatoid arthritis (RA) patients in clinical remission. PATIENTS AND METHODS: We included patients with RA in clinical remission, defined as 28-joint disease activity score (DAS28)-erythrocyte sedimentation rate (ESR) <2.6 for >6 months. Ultrasound scans of both hands and knees and MRI of the dominant hand were performed at baseline and at 12 months...
May 1, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28549718/sarcopenia-is-associated-with-physical-and-mental-components-of-health-related-quality-of-life-in-older-adults
#10
Betty Manrique-Espinoza, Aarón Salinas-Rodríguez, Oscar Rosas-Carrasco, Luis Miguel Gutiérrez-Robledo, José Alberto Avila-Funes
OBJECTIVES: To estimate the association between sarcopenia and the health-related quality of life (HRQoL) among community-dwelling older adults. DESIGN: Cross-sectional analysis of a prospective cohort. SETTING: The Rural Frailty Study, a prospective study on the prevalence of frailty in rural settings in Mexico, with baseline and follow-up measurements conducted in 2009 and 2013, respectively. PARTICIPANTS: Five hundred forty-three men and women older than 70 years...
May 23, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28549702/iagg-iagg-garn-international-survey-of-end-of-life-care-in-nursing-homes
#11
Cara L Wallace, Daniel Swagerty, Mario Barbagallo, Bruno Vellas, Heung Bong Cha, Iva Holmerova, Birong Dong, Raymond Koopmans, Alfonso J Cruz-Jentoft, Luis Miguel Gutierrez Robledo, Juan Cuadros Moreno, Ramzi Hajjar, Jean Woo, Hidenori Arai, Jiro Okochi, Renuka Visvanathan, Samia A Abdul-Rahman, Ashish Goel, Andrea Moser, Yves Rolland, Angela M Abbatecola, Marcello Russo, John E Morley
This article reports the findings of a survey on end-of-life (EOL) care in nursing homes of 18 long-term care experts across 15 countries. The experts were chosen as a convenience-based sample of known experts in each country. The survey was administered in 2016 and included both open-ended responses for defining hospice care, palliative care, and "end of life," and a series of questions related to the following areas-attitudes toward EOL care, current practice and EOL interventions, structure of care, and routine barriers...
June 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28549577/-child-behaviour-problems-and-parenting-skills-of-mothers-in-environments-of-intimate-partner-violence
#12
Ana Rosser Limiñana, Raquel Suriá Martínez, Miguel Ángel Mateo Pérez
OBJECTIVE: To assess the behavioural problems of children who have been exposed to intimate partner violence situations, and the moderating effect of mother parenting. METHOD: We analysed, using the Child Behavior CheckList, behavioural problems of 46 children between 6 and 16 years, and the relationship between the detected problems and parenting skills shown in the mother-child interaction in shelters. RESULTS: Increased behavioural problems were detected in children, compared with normative population...
May 23, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28549558/the-kv1-3-channel-blocker-vm24-enhances-muscle-glucose-transporter-4-mobilization-but-does-not-reduce-body-weight-gain-in-diet-induced-obese-male-rats
#13
Lorraine Jaimes-Hoy, Georgina B Gurrola, Miguel Cisneros, Patricia Joseph-Bravo, Lourival D Possani, Jean-Louis Charli
AIMS: Voltage-gated potassium channels 1.3 (Kv1.3) can be targeted to reduce diet-induced obesity and insulin resistance in mice. Since species-specific differences in Kv1.3 expression and pharmacology have been observed, we tested the effect of Vm24, a high-affinity specific blocker of Kv1.3 channels from Vaejovis mexicanus smithi, on body weight (BW), glucose tolerance and insulin resistance in diet-induced obese rats. MATERIALS AND METHODS: Young adult male Wistar rats were switched to a high-fat/high-fructose (HFF) diet...
May 23, 2017: Life Sciences
https://www.readbyqxmd.com/read/28549524/-quadratus-lumborum-block-are-we-aware-of-its-side-effects-a-report-of-2-cases
#14
Miguel Sá, José Miguel Cardoso, Hugo Reis, Marta Esteves, José Sampaio, Isabel Gouveia, Pilar Carballada, Célia Pinheiro, Duarte Machado
BACKGROUND AND OBJECTIVES: The quadratus lumborum block was initially described in 2007 and aims at blocking the same nerves as the ones involved on the Transverse Abdominis Plane block, while accomplishing some visceral enervation as well due to closer proximity with the neuroaxis and sympathetic trunk. Given its versatility, we have successfully used it in a wide range of procedures. We report two cases where we believe the dispersion of local anesthetic is likely to have led to a previously undescribed complication...
May 23, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/28549153/chippi-a-novel-method-for-mapping-chimeric-protein-protein-interactions-uncovers-selection-principles-of-protein-fusion-events-in-cancer
#15
Milana Frenkel-Morgenstern, Alessandro Gorohovski, Somnath Tagore, Vaishnovi Sekar, Miguel Vazquez, Alfonso Valencia
Fusion proteins, comprising peptides deriving from the translation of two parental genes, are produced in cancer by chromosomal aberrations. The expressed fusion protein incorporates domains of both parental proteins. Using a methodology that treats discrete protein domains as binding sites for specific domains of interacting proteins, we have cataloged the protein interaction networks for 11 528 cancer fusions (ChiTaRS-3.1). Here, we present our novel method, chimeric protein-protein interactions (ChiPPI) that uses the domain-domain co-occurrence scores in order to identify preserved interactors of chimeric proteins...
May 26, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28548698/novel-porcine-experimental-model-of-severe-progressive-thoracic-scoliosis-with-compensatory-curves-induced-by-interpedicular-bent-rigid-temporary-tethering
#16
Carlos Barrios, José Miguel Lloris, Juan Alonso, Borja Maruenda, Jesús Burgos, Rafael Llombart-Blanco, Luis Gil, Viviana Bisbal
Using flexible tethering techniques, porcine models of experimental scoliosis have shown scoliotic curves with vertebral wedging but very limited axial rotation. The aim of this experimental work was to induce a severe progressive scoliosis in a growing porcine model for research purposes. A unilateral spinal bent rigid tether was anchored to two ipsilateral pedicle screws in eight pigs. The spinal tether was removed after 8 weeks. Ten weeks later, the animals were sacrificed. Conventional radiographs and 3D CT-scans were taken to evaluate changes in the alignment of the thoracic spine...
May 26, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28548582/bilateral-iris-depigmentation-and-ocular-hypotony-as-end-stage-manifestations-of-untreated-vogt-koyanagi-harada-disease
#17
Miguel Cuevas, Alejandra de-la-Torre, Andrea Córdoba
PURPOSE: To describe severe bilateral iris depigmentation and persistent ocular hypotony as end-stage manifestations of untreated Vogt-Koyanagi-Harada disease. METHODS: We present the clinical findings and diagnostic studies performed for three patients with bilateral iris depigmentation. RESULTS: Vogt-Koyanagi-Harada disease in late recurrent stage was diagnosed in three patients with bilateral severe iris depigmentation and persistent ocular hypotony...
May 26, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28548085/ultrafast-coherence-transfer-in-dna-templated-silver-nanoclusters
#18
Erling Thyrhaug, Sidsel Ammitzbøll Bogh, Miguel R Carro-Temboury, Charlotte Stahl Madsen, Tom Vosch, Donatas Zigmantas
DNA-templated silver nanoclusters of a few tens of atoms or less have come into prominence over the last several years due to very strong absorption and efficient emission. Applications in microscopy and sensing have already been realized, however little is known about the excited-state structure and dynamics in these clusters. Here we report on a multidimensional spectroscopy investigation of the energy-level structure and the early-time relaxation cascade, which eventually results in the population of an emitting state...
May 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28547991/enhancing-enantiomeric-separation-with-strain-the-case-of-serine-on-cu-531
#19
Yonghui Wang, Sha Yang, Miguel Fuentes-Cabrera, Shuang Li, Wei Liu
Serine has two enantiomers, D and L, which exhibit identical physical and chemical properties but have dramatically different physiological effects. For the pharmaceutical industry, it is thus very important to be able to separate both enantiomers. Using density-functional theory with an accurate treatment of the van der Waals interactions, here we study the enantioselectivity of the (531) surfaces of Cu, Ag, Au, and Pd. Among these surfaces, it is found that Cu(531) is the more efficient one for energetically separating serine enantiomers...
May 26, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28547871/sequence-based-analysis-of-protein-degradation-rates-a-computational-study-of-protein-degradation
#20
Miguel Correa Marrero, Aalt D J van Dijk, Dick de Ridder
Protein turnover is a key aspect of cellular homeostasis and proteome dynamics. However, there is little consensus on which properties of a protein determine its lifetime in the cell. In this work, we exploit two reliable datasets of experimental protein degradation rates to learn models and uncover determinants of protein degradation, with particular focus on properties that can be derived from the sequence. Our work shows that simple sequence features suffice to obtain predictive models of which the output correlates reasonably well with the experimentally measured values...
May 25, 2017: Proteins
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