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https://www.readbyqxmd.com/read/28098875/exposure-to-tnf%C3%A2-%C3%AE-combined-with-tgf%C3%A2-%C3%AE-induces-carcinogenesis-in-vitro-via-nf-%C3%AE%C2%BAb-twist-axis
#1
Weilei Dong, Shuwen Sun, Xiaocheng Cao, Yinghong Cui, A Chen, Xiang Li, Jiansong Zhang, Jianguo Cao, Yifeng Wang
Persistent human papilloma virus (HPV) infection induces chronic inflammation resulting in human cervical cancer. However, the mechanisms underlying carcinogenesis via chronic inflammation remain largely unclear. We investigated the role of pro-inflammatory factors in epithelial-mesenchymal transition (EMT) and cancer stem cell-like (CSCL) characteristics of HeLa cells exposed to TNF‑α with or without TGF‑β. We then determined the role of NF-κB/Twist signal axis in the pathogenesis of cervical cancer...
January 16, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28098832/therapeutic-potential-of-targeting-the-th17-treg-axis-in-autoimmune-disorders
#2
REVIEW
Patrizia Fasching, Martin Stradner, Winfried Graninger, Christian Dejaco, Johannes Fessler
A disruption of the crucial balance between regulatory T-cells (Tregs) and Th17-cells was recently implicated in various autoimmune disorders. Tregs are responsible for the maintenance of self-tolerance, thus inhibiting autoimmunity, whereas pro-inflammatory Th17-cells contribute to the induction and propagation of inflammation. Distortion of the Th17/Treg balance favoring the  pro-inflammatory Th17 side is hence suspected to contribute to exacerbation of autoimmune disorders. This review aims to summarize recent data and advances in targeted therapeutic modification of the Th17/Treg-balance, as well as information on the efficacy of candidate therapeutics with respect to the treatment of autoimmune diseases...
January 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28098777/new-irradiation-method-with-indocyanine-green-loaded-nanospheres-for-inactivating-periodontal-pathogens
#3
Yasuyuki Sasaki, Jun-Ichiro Hayashi, Takeki Fujimura, Yuki Iwamura, Genta Yamamoto, Eisaku Nishida, Tasuku Ohno, Kosuke Okada, Hiromitsu Yamamoto, Takeshi Kikuchi, Akio Mitani, Mitsuo Fukuda
Antimicrobial photodynamic therapy (aPDT) has been proposed as an adjunctive strategy for periodontitis treatments. However, use of aPDT for periodontal treatment is complicated by the difficulty in accessing morphologically complex lesions such as furcation involvement, which the irradiation beam (which is targeted parallel to the tooth axis into the periodontal pocket) cannot access directly. The aim of this study was to validate a modified aPDT method that photosensitizes indocyanine green-loaded nanospheres through the gingivae from outside the pocket using a diode laser...
January 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28098711/primary-septal-cartilage-graft-for-the-unilateral-cleft-rhinoplasty
#4
Ting-Chen Lu, Chuan-Fong Yao, Susie Lin, Chun-Shin Chang, Philip Kuo-Ting Chen
PROPOSE: Since 2006, we have explored the option of using septal cartilage as an alar rim graft on the cleft side during primary rhinoplasty to improve nasal symmetry. The aim of this study was to compare the nasal shape with or without rim graft. METHODS: A total of 98 patients with unilateral complete cleft lip and palate were included; 39 patients had septal cartilage as the rim graft, 59 patients did not. Measurements of the nostril height, nostril width, 1/4 medial part of nostril height, nostril area, nasal dome height and nostril axis were made on the cleft and non-cleft side...
January 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28098159/fluid-shear-stress-activates-yap1-to-promote-cancer-cell-motility
#5
Hyun Jung Lee, Miguel F Diaz, Katherine M Price, Joyce A Ozuna, Songlin Zhang, Eva M Sevick-Muraca, John P Hagan, Pamela L Wenzel
Mechanical stress is pervasive in egress routes of malignancy, yet the intrinsic effects of force on tumour cells remain poorly understood. Here, we demonstrate that frictional force characteristic of flow in the lymphatics stimulates YAP1 to drive cancer cell migration; whereas intensities of fluid wall shear stress (WSS) typical of venous or arterial flow inhibit taxis. YAP1, but not TAZ, is strictly required for WSS-enhanced cell movement, as blockade of YAP1, TEAD1-4 or the YAP1-TEAD interaction reduces cellular velocity to levels observed without flow...
January 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28097650/scaling-of-pattern-formations-and-morphogen-gradients
#6
REVIEW
Hidehiko Inomata
The concentration gradient of morphogens provides positional information for an embryo and plays a pivotal role in pattern formation of tissues during the developmental processes. Morphogen-dependent pattern formations show robustness despite various perturbations. Although tissues usually grow and dynamically change their size during histogenesis, proper patterns are formed without the influence of size variations. Furthermore, even when the blastula embryo of Xenopus laevis is bisected into dorsal and ventral halves, the dorsal half of the embryo leads to proportionally patterned half-sized embryos...
January 17, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28097637/moving-from-patient-advocacy-to-partnership-a-long-and-bumpy-road
#7
Durhane Wong-Rieger
Real-life experiences of grassroots patient organizations across a variety of diseases, countries and contexts have been used to develop a four-mode framework of the transition from patient advocacy to partnership, defined by one axis as individual versus collective action and the other axis as activities 'outside' or 'inside' the system. The four quadrants are labeled as advocacy, activism, reform and broker, and engagement is further refined by whether the participation is 'pushed' by the group or 'pulled' by the system...
January 17, 2017: Patient
https://www.readbyqxmd.com/read/28097598/influence-of-doping-and-nanostructuration-on-n-type-bi2-te0-8se0-2-3-alloys-synthesized-by-arc-melting
#8
Mouna Gharsallah, Federico Serrano-Sanchez, Norbert M Nemes, Jose Luis Martinez, Jose Antonio Alonso
In competitive thermoelectric devices for energy conversion and generation, high-efficiency materials of both n-type and p-type are required. For this, Bi2Te3-based alloys have the best thermoelectric properties in room temperature applications. Partial replacement of tellurium by selenium is expected to introduce new donor states in the band gap, which would alter electrical conductivity and thermopower. We report on the preparation of n-type Bi2(Te1-xSex)3 solid solutions by a straightforward arc-melting technique, yielding nanostructured polycrystalline pellets...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28097597/self-powered-active-sensor-with-concentric-topography-of-piezoelectric-fibers
#9
Yiin Kuen Fuh, Zih Ming Huang, Bo Sheng Wang, Shan Chien Li
In this study, we demonstrated a flexible and self-powered sensor based on piezoelectric fibers in the diameter range of nano- and micro-scales. Our work is distinctively different from previous electrospinning research; we fabricated this apparatus precisely via near-field electrospinning which has a spectacular performance to harvest mechanical deformation in arbitrary direction and a novel concentrically circular topography. There are many piezoelectric devices based on electrospinning polymeric fibers. However, the fibers were mostly patterned in parallel lines and they could be actuated in limited direction only...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28097394/the-morphology-and-morphometry-of-the-fovea-capitis-femoris
#10
Vivek Perumal, Stephanie J Woodley, Helen D Nicholson
BACKGROUND: There is little published information on the anatomy of the fovea capitis femoris (FCF), the distal attachment site of the ligament of the head of femur (LHF). This study investigates the morphology of the FCF on dry bones in an attempt to answer some of the debate around the functional significance of the LHF. METHODS: The morphological and morphometric details of the FCF were analysed on 125 dry isolated femora (n = 125) from the Anatomy Museum, University of Otago, New Zealand...
January 17, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28097232/vps34-regulates-myofibril-proteostasis-to-prevent-hypertrophic-cardiomyopathy
#11
Hirotaka Kimura, Satoshi Eguchi, Junko Sasaki, Keiji Kuba, Hiroki Nakanishi, Shunsuke Takasuga, Masakazu Yamazaki, Akiteru Goto, Hiroyuki Watanabe, Hiroshi Itoh, Yumiko Imai, Akira Suzuki, Noboru Mizushima, Takehiko Sasaki
Hypertrophic cardiomyopathy (HCM) is a common heart disease with a prevalence of 1 in 500 in the general population. Several mutations in genes encoding cardiac proteins have been found in HCM patients, but these changes do not predict occurrence or prognosis and the molecular mechanisms underlying HCM remain largely elusive. Here we show that cardiac expression of vacuolar protein sorting 34 (Vps34) is reduced in a subset of HCM patients. In a mouse model, muscle-specific loss of Vps34 led to HCM-like manifestations and sudden death...
January 12, 2017: JCI Insight
https://www.readbyqxmd.com/read/28096541/the-mucosal-immune-system-master-regulator-of-bidirectional-gut-brain-communications
#12
REVIEW
Nick Powell, Marjorie M Walker, Nicholas J Talley
Communication between the brain and gut is not one-way, but a bidirectional highway whereby reciprocal signals between the two organ systems are exchanged to coordinate function. The messengers of this complex dialogue include neural, metabolic, endocrine and immune mediators responsive to diverse environmental cues, including nutrients and components of the intestinal microbiota (microbiota-gut-brain axis). We are now starting to understand how perturbation of these systems affects transition between health and disease...
January 18, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28096522/control-of-food-intake-by-gastrointestinal-peptides-mechanisms-of-action-and-possible-modulation-in-the-treatment-of-obesity
#13
REVIEW
Philip Prinz, Andreas Stengel
This review focuses on the control of appetite by food intake-regulatory peptides secreted from the gastrointestinal tract, namely cholecystokinin, glucagon-like peptide 1, peptide YY, ghrelin, and the recently discovered nesfatin-1 via the gut-brain axis. Additionally, we describe the impact of external factors such as intake of different nutrients or stress on the secretion of gastrointestinal peptides. Finally, we highlight possible conservative-physical activity and pharmacotherapy-treatment strategies for obesity as well as surgical techniques such as deep brain stimulation and bariatric surgery also altering these peptidergic pathways...
January 17, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28096421/rfamide-related-peptide-3-rfrp-3-suppresses-sexual-maturation-in-a-eusocial-mammal
#14
Diana E Peragine, Martha Pokarowski, Lucia Mendoza-Viveros, Ashlyn Swift-Gallant, Hai-Ying M Cheng, George E Bentley, Melissa M Holmes
Neuroendocrine mechanisms underlying social inhibition of puberty are not well understood. Here, we use a model exhibiting the most profound case of pubertal suppression among mammals to explore a role for RFamide-related peptide-3 [RFRP-3; mammalian ortholog to gonadotropin-inhibitory hormone (GnIH)] in neuroendocrine control of reproductive development. Naked mole rats (NMRs) live in sizable colonies where breeding is monopolized by two to four dominant animals, and no other members exhibit signs of puberty throughout their lives unless they are removed from the colony...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28096348/transcriptomic-proteomic-and-metabolomic-landscape-of-positional-memory-in-the-caudal-fin-of-zebrafish
#15
Jeremy S Rabinowitz, Aaron M Robitaille, Yuliang Wang, Catherine A Ray, Ryan Thummel, Haiwei Gu, Danijel Djukovic, Daniel Raftery, Jason D Berndt, Randall T Moon
Regeneration requires cells to regulate proliferation and patterning according to their spatial position. Positional memory is a property that enables regenerating cells to recall spatial information from the uninjured tissue. Positional memory is hypothesized to rely on gradients of molecules, few of which have been identified. Here, we quantified the global abundance of transcripts, proteins, and metabolites along the proximodistal axis of caudal fins of uninjured and regenerating adult zebrafish. Using this approach, we uncovered complex overlapping expression patterns for hundreds of molecules involved in diverse cellular functions, including development, bioelectric signaling, and amino acid and lipid metabolism...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28096294/mouse-modeling-of-the-mdm2-mdmx-p53-signaling-axis
#16
REVIEW
Nicole R Tackmann, Yanping Zhang
It is evident that p53 activity is critical for tumor prevention and stress response through its transcriptional activation of genes affecting cellular senescence, apoptosis, cellular metabolism, and DNA repair. The regulation of p53 is highly complex, and MDM2 and MDMX are thought to be critical for deciding the fate of p53, both through inhibitory binding and posttranslational modification. Many mouse models have been generated to study the regulation of p53 in vivo, and they have altered our interpretations of how p53 is regulated by MDM2 and MDMX...
January 17, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28096292/regulation-of-kidney-development-by-the-mdm2-mdm4-p53-axis
#17
REVIEW
Samir El-Dahr, Sylvia Hilliard, Zubaida Saifudeen
While p53 activity is required for tumor suppression, unconstrained p53 activity on the other hand is detrimental to the organism, resulting in inappropriate cellular death or proliferation defects. Unimpeded p53 activity is lethal in the developing embryo, underlining the need for maintaining a tight control on p53 activity during this period. The critical role of the negative regulators of p53, Mdm2 and Mdm4, in vertebrate development came to light by fatal disruption of embryogenesis that was observed with Mdm2 and Mdm4 gene deletions in mice...
January 17, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28095864/microrna-141-enhances-anoikis-resistance-in-metastatic-progression-of-ovarian-cancer-through-targeting-klf12-sp1-survivin-axis
#18
Celia S L Mak, Mingo M H Yung, Lynn M N Hui, Leanne L Leung, Rui Liang, Kangmei Chen, Stephanie S Liu, Yiming Qin, Thomas H Y Leung, Kai-Fai Lee, Karen K L Chan, Hextan Y S Ngan, David W Chan
BACKGROUND: Cancer metastasis is determined by the formation of the metastatic niche and the ability of cancer cells to adapt to microenvironmental stresses. Anoikis resistance is a fundamental feature of metastatic cancer cell survival during metastatic cancer progression. However, the mechanisms underlying anoikis resistance in ovarian cancer are still unclear. METHODS: Expressions of miRNA-141 and its downstream targets were evaluated by qPCR, Western blotting, Immunohistochemical (IHC) and in situ hybridization (ISH) assays...
January 17, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28095819/adhd-comorbid-disorders-and-psychosocial-functioning-how-representative-is-a-child-cohort-study-findings-from-a-national-patient-registry
#19
Beate Oerbeck, Kristin Romvig Overgaard, Stian Thoresen Aspenes, Are Hugo Pripp, Marianne Mordre, Heidi Aase, Ted Reichborn-Kjennerud, Pal Zeiner
BACKGROUND: Cohort studies often report findings on children with Attention Deficit Hyperactivity Disorder (ADHD) but may be biased by self-selection. The representativeness of cohort studies needs to be investigated to determine whether their findings can be generalised to the general child population. The aim of the present study was to examine the representativeness of child ADHD in the Norwegian Mother and Child Cohort Study (MoBa). METHODS: The study population was children born between January 1, 2000 and December 31, 2008 registered with hyperkinetic disorders (hereafter ADHD) in the Norwegian Patient Registry during the years 2008-2013, and two groups of children with ADHD were identified in: 1...
January 17, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28095739/expression-and-localization-of-fibroblast-growth-factor-fgf-23-and-klotho-in-the-spleen-its-physiological-and-functional-implications
#20
Yuri Nakashima, Toru Mima, Mitsuru Yashiro, Tomohiro Sonou, Masaki Ohya, Asuka Masumoto, Shintaro Yamanaka, Daisuke Koreeda, Koichi Tatsuta, Yoshiyuki Hanba, Mari Moribata, Shigeo Negi, Takashi Shigematsu
The FGF23-Klotho signaling axis is known to exert anti-aging effects via calcium-phosphorus metabolism. In mice deficient in FGF23-Klotho signaling, however, the number of splenocytes is reduced. FGF23 is expressed in both bone and spleen, with regulation of its production differing in these organs. As FGF23-Klotho signaling may play an immunological role in the spleen, splenocytes in male C57BL/6J mice were assayed for expression of Klotho or FGF23 by flow cytometry and immunohistochemistry. Cells that expressed Klotho included CD45R/B220(+) CD21/CD35(+) CD1d(+) CD43(-) marginal zone B cells...
January 18, 2017: Growth Factors
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