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https://www.readbyqxmd.com/read/28938747/prevalence-of-endocrine-and-genetic-abnormalities-in-boys-evaluated-systematically-for-a-disorder-of-sex-development
#1
R Nixon, V Cerqueira, A Kyriakou, A Lucas-Herald, J McNeilly, M McMillan, A I Purvis, E S Tobias, R McGowan, S F Ahmed
STUDY QUESTION: What is the likelihood of identifying genetic or endocrine abnormalities in a group of boys with 46, XY who present to a specialist clinic with a suspected disorder of sex development (DSD)? SUMMARY ANSWER: An endocrine abnormality of the gonadal axis may be present in a quarter of cases and copy number variants (CNVs) or single gene variants may be present in about half of the cases. WHAT IS KNOWN ALREADY: Evaluation of 46, XY DSD requires a combination of endocrine and genetic tests but the prevalence of these abnormalities in a sufficiently large group of boys presenting to one specialist multidisciplinary service is unclear...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28938623/mifepristone-inhibits-ovarian-cancer-metastasis-by-intervening-in-sdf-1-cxcr4-chemokine-axis
#2
Ning Zheng, Jiahang Chen, Weiqun Liu, Jian Liu, Tao Li, Hongning Chen, Jichuang Wang, Lee Jia
SDF-1/CXCR4 signaling axis determines the proliferative potential and site-specific cancer metastasis. Recent studies suggest involvement of the axis and steroidal hormone in ovarian cancer metastasis. Here we hypothesize that mifepristone (RU486), a well-known progesterone-based abortifacient, might interfere this axis and inhibit ovarian cancer metastasis. Mifepristone at concentrations < IC50 inhibited expression of CXCR4 on cell surface of ovarian cancer SKOV-3 and IGROV-1, and reduced expression of the intracellular CXCR4 protein and its related mRNA activated by SDF-1...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938585/the-trophoblast-cell-surface-antigen-2-and-mir-125b-axis-in-urothelial-bladder-cancer
#3
Chiara Avellini, Caterina Licini, Raffaella Lazzarini, Rosaria Gesuita, Emanuela Guerra, Giovanni Tossetta, Clara Castellucci, Stefano Raffaele Giannubilo, Antonio Procopio, Saverio Alberti, Roberta Mazzucchelli, Fabiola Olivieri, Daniela Marzioni
Human trophoblast cell surface antigen 2 (Trop-2) is a 40-kDa transmembrane glycoprotein that was first identified as a marker of human trophoblast cells. Trop-2 acts on cell proliferation, adhesion, and migration by activating a number of intracellular signalling pathways. Elevated Trop-2 expression has been demonstrated in several types of cancer and correlated with aggressiveness and poor prognosis. Since no data are available on Trop-2 in bladder cancer (BC), the purpose of the study was to determine its levels in tissue specimens from normal individuals and patients with BC at different stages...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938481/vesicular-glutamate-transporter-1-knockdown-in-infralimbic-prefrontal-cortex-augments-neuroendocrine-responses-to-chronic-stress-in-male-rats
#4
Brent Myers, Jessica M McKlveen, Rachel Morano, Yvonne M Ulrich-Lai, Matia B Solomon, Steven P Wilson, James P Herman
Chronic stress-associated pathologies frequently associate with alterations in the structure and activity of medial prefrontal cortex (mPFC). However, the influence of infralimbic cortex (IL) projection neurons on HPA axis activity is unknown, as is the involvement of these cells in chronic stress-induced endocrine alterations. In the current study, a lentiviral-packaged vector coding for a small interfering RNA (siRNA) targeting vesicular glutamate transporter 1 (vGluT1) mRNA was microinjected into the IL of male rats...
July 25, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938475/modeling-the-sex-differences-and-inter-individual-variability-in-the-activity-of-the-hypothalamic-pituitary-adrenal-axis
#5
Rohit T Rao, Ioannis P Androulakis
Significant sex differences exist in the activity of the hypothalamic-pituitary-adrenal (HPA) axis. These differences are thought to contribute to the disparity in the prevalence of various autoimmune and infectious diseases between males and females. We use a mathematical model of the HPA axis to evaluate the hypothesis that differential sensitivity and negative feedback of the HPA axis network are causal factors for the observed sex differences in its activity. In doing so, we implicitly account for the differential influence of gonadal hormones on the HPA axis...
August 31, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938470/genetic-disruption-of-21-hydroxylase-in-zebrafish-causes-interrenal-hyperplasia
#6
Helen Eachus, Andreas Zaucker, James A Oakes, Aliesha Griffin, Meltem Weger, Tülay Güran, Angela Taylor, Abigail Harris, Andy Greenfield, Jonathan L Quanson, Karl-Heinz Storbeck, Vincent T Cunliffe, Ferenc Müller, Nils Krone
Congenital adrenal hyperplasia is a group of common inherited disorders leading to glucocorticoid deficiency. Most cases are caused by 21-hydroxylase deficiency (21OHD). The systemic consequences of imbalanced steroid hormone biosynthesis due to severe 21OHD remains poorly understood. Therefore, we have developed a zebrafish model for 21OHD, which focuses on the impairment of glucocorticoid biosynthesis. A single 21-hydroxylase gene (cyp21a2) is annotated in the zebrafish genome based on sequence homology. Our in silico analysis of the Cyp21a2 protein sequence suggests a sufficient degree of similarity for the usage of zebrafish cyp21a2 to model aspects of human 21OHD in vivo...
September 13, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938412/renal-metabolic-programming-is-linked-to-the-dynamic-regulation-of-a-leptin-klf15-axis-and-akt-ampk%C3%AE-signaling-in-male-offspring-of-obese-dams
#7
Philipp Kasper, Christina Vohlen, Katharina Dinger, Jasmine Mohr, Eva Hucklenbruch-Rother, Ruth Janoschek, Jessica Köth, Jan Matthes, Sarah Appel, Jörg Dötsch, Miguel A Alejandre Alcazar
Childhood obesity is associated with renal diseases. Maternal obesity is a risk factor linked to increased adipocytokines and metabolic disorders in the offspring. We therefore studied the impact of maternal obesity on renal-intrinsic insulin and adipocytokine signaling and on renal function and structure. To induce maternal obesity female mice were fed with high-fat diet (HFD) or standard diet (SD, Co) prior to mating, during gestation and throughout lactation. A third group of dams was fed HFD only during lactation (HFD-Lac)...
July 27, 2017: Endocrinology
https://www.readbyqxmd.com/read/28938251/critical-illness-related-corticosteroid-insufficiency-circi-a-narrative-review-from-a-multispecialty-task-force-of-the-society-of-critical-care-medicine-sccm-and-the-european-society-of-intensive-care-medicine-esicm
#8
Djillali Annane, Stephen M Pastores, Wiebke Arlt, Robert A Balk, Albertus Beishuizen, Josef Briegel, Joseph Carcillo, Mirjam Christ-Crain, Mark S Cooper, Paul E Marik, Gianfranco Umberto Meduri, Keith M Olsen, Bram Rochwerg, Sophia C Rodgers, James A Russell, Greet Van den Berghe
OBJECTIVE: To provide a narrative review of the latest concepts and understanding of the pathophysiology of critical illness-related corticosteroid insufficiency (CIRCI). PARTICIPANTS: A multi-specialty task force of international experts in critical care medicine and endocrinology and members of the Society of Critical Care Medicine and the European Society of Intensive Care Medicine. DATA SOURCES: Medline, Database of Abstracts of Reviews of Effects (DARE), Cochrane Central Register of Controlled Trials (CENTRAL) and the Cochrane Database of Systematic Reviews...
September 21, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28938245/gallic-acid-induces-g1-phase-arrest-and-apoptosis-of-triple-negative-breast-cancer-cell-mda-mb-231-via-p38-mitogen-activated-protein-kinase-p21-p27-axis
#9
Hsiang-Lin Lee, Chun-Shiang Lin, Shao-Hsuan Kao, Ming-Chih Chou
Gallic acid (GA) possesses potential antitumoral activity on different types of malignancies. In this study, we aimed to explore the antitumoral effects of GA on triple-negative breast cancer (TNBC) cells, the breast cancer cells showing resistance to hormonal therapy or HER2 receptor targeting therapy. We observed that GA treatment significantly decreased the cell viability of human TNBC cell line MDA-MB-231 and HS578T in a dose-dependent manner. In addition, GA exerted a relative lower cytotoxicity on noncancer breast fibroblast MCF-10F...
September 21, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28938158/directional-migration-in-esophageal-squamous-cell-carcinoma-escc-is-epigenetically-regulated-by-set-nuclear-oncogene-a-member-of-the-inhibitor-of-histone-acetyltransferase-complex
#10
Xiang Yuan, Xinshuai Wang, Bianli Gu, Yingjian Ma, Yiwen Liu, Man Sun, Jinyu Kong, Wei Sun, Huizhi Wang, Fuyou Zhou, Shegan Gao
Directional cell migration is of fundamental importance to a variety of biological events, including metastasis of malignant cells. Herein, we specifically investigated SET oncoprotein, a subunit of the recently identified inhibitor of acetyltransferases (INHAT) complex and identified its role in the establishment of front-rear cell polarity and directional migration in Esophageal Squamous Cell Carcinoma (ESCC). We further define the molecular circuits that govern these processes by showing that SET modulated DOCK7/RAC1 and cofilin signaling events...
September 19, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28938021/alterations-in-the-ability-to-maintain-balance-as-a-result-of-stochastic-resonance-whole-body-vibration-in-women
#11
Karolina Donocik, Magdalena Hartman-Petrycka, Agata Lebiedowska, Barbara Błońska-Fajfrowska
PURPOSE: A vertical posture makes it difficult to maintain balance especially in the elderly. Loss of balance leads to falls and injuries. In the present study, we evaluated whether balance maintenance can be improved with the use of stochastic resonance whole body vibration (SR-WBV). METHODS: An examination of balance, involving 187 women aged 19-74 years, was conducted using double-plate posturography pre and post SR-WBV. The SR-WBV trainings were performed using the SRT Zeptor Medical-plus noise device...
2017: PloS One
https://www.readbyqxmd.com/read/28937803/hip-arthroscopy-for-femoroacetabular-impingement-in-a-military-population
#12
Darren D Thomas, Andrew S Bernhardson, Ethan Bernstein, Christopher B Dewing
BACKGROUND: Femoroacetabular impingement (FAI) can lead to hip pain and early joint degeneration. There have been few reports to date on the outcomes of hip arthroscopy for the treatment of FAI in the military population. Purpose/Hypothesis: The purpose of this study was to compare patient demographics with postoperative outcomes after hip arthroscopy for symptomatic FAI and to identify preoperative risk factors for poor outcomes. The hypothesis was that certain preoperative patient characteristics will be predictive of poorer outcomes and that lower outcomes scores will be associated with a higher likelihood of medical separation from the military...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28937663/a-metallo-dna-nanowire-with-uninterrupted-one-dimensional-silver-array
#13
Jiro Kondo, Yoshinari Tada, Takenori Dairaku, Yoshikazu Hattori, Hisao Saneyoshi, Akira Ono, Yoshiyuki Tanaka
The double-helix structure of DNA, in which complementary strands reversibly hybridize to each other, not only explains how genetic information is stored and replicated, but also has proved very attractive for the development of nanomaterials. The discovery of metal-mediated base pairs has prompted the generation of short metal-DNA hybrid duplexes by a bottom-up approach. Here we describe a metallo-DNA nanowire-whose structure was solved by high-resolution X-ray crystallography-that consists of dodecamer duplexes held together by four different metal-mediated base pairs (the previously observed C-Ag-C, as well as G-Ag-G, G-Ag-C and T-Ag-T) and linked to each other through G overhangs involved in interduplex G-Ag-G...
October 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28937503/patient-burden-of-axial-spondyloarthritis
#14
Vibeke Strand, Jasvinder A Singh
Axial spondyloarthritis (AxSpA) is an inflammatory spondyloarthritis (SpA) that has significant impact on a patient's life. Symptoms, including fatigue, sleep problems, depression, and sexual dysfunction, can profoundly impact health-related quality of life (HRQoL) and limit work, leisure, and daily activities. Available therapies effectively manage pain and inflammation in early-stage disease, but patients often continue to experience impaired HRQoL. Thus, there remains a need for new therapies with novel mechanisms that can stop disease progression, potentially reverse damage caused by AxSpA and improve HRQoL in patients with AxSpA...
September 21, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937474/patient-burden-of-axial-spondyloarthritis
#15
Vibeke Strand, Jasvinder A Singh
Axial spondyloarthritis (AxSpA) is an inflammatory spondyloarthritis (SpA) that has significant impact on a patient's life. Symptoms, including fatigue, sleep problems, depression, and sexual dysfunction, can profoundly impact health-related quality of life (HRQoL) and limit work, leisure, and daily activities. Available therapies effectively manage pain and inflammation in early-stage disease, but patients often continue to experience impaired HRQoL. Thus, there remains a need for new therapies with novel mechanisms that can stop disease progression, potentially reverse damage caused by AxSpA and improve HRQoL in patients with AxSpA...
October 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937417/age-related-changes-in-ocular-aberrations-and-the-yamagata-study-funagata
#16
Hiroyuki Namba, Ryo Kawasaki, Akira Sugano, Takanori Murakami, Koichi Nishitsuka, Takeo Kato, Takamasa Kayama, Hidetoshi Yamashita
Human vision quality is influenced by ocular aberrations, including astigmatism and higher-order aberrations (HOAs), in combination with other optical factors. In this study, we introduce the results and perceptions of previous studies investigating these aberrations. We also introduce our results obtained as part of the Yamagata Study (Funagata), a population-based epidemiologic study. To investigate the astigmatic change with age, researchers have used the power vector analysis, allowing incorporation of the magnitude and axis of astigmatism into statistical analyses...
September 19, 2017: Cornea
https://www.readbyqxmd.com/read/28937175/chiral-six-coordinate-dy-iii-and-tb-iii-complexes-of-an-achiral-ligand-structure-fluorescence-and-magnetism
#17
Mei-Jiao Liu, Juan Yuan, Yi-Quan Zhang, Hao-Ling Sun, Cai-Ming Liu, Hui-Zhong Kou
Two new chiral six-coordinate lanthanide complexes (1 for Dy and 2 for Tb) have been synthesized using the achiral flexible ligand H2L (2,2'-[1,2-ethanediylbis[(methylimino)methylene]]bis[4,5-dimethylphenol]). Both complexes crystallize in the chiral P1 group space, and the enantiomers [Zn(L)Cl]3Dy·MeOH·0.5H2O (Λ-1), [Zn(L)Cl]3Dy·1.5H2O (Δ-1), [Zn(L)Cl]3Tb·1.5H2O (Λ-2) and [Zn(L)Cl]3Tb·H2O (Δ-2) are isolated in the reaction. Three [Zn(L)Cl](-) anions coordinate to the central lanthanide ion using two phenoxo oxygen atoms of L(2-), and the lanthanide ion has the coordination geometry of D3...
September 22, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28936813/-clinical-and-sociodemographic-characteristics-that-affect-the-recommendation-for-assignment-of-a-legal-representative-in-patients-with-bipolar-disorder
#18
Erhan Akıncı, Fatih Öncü, Can Ger, Mustafa Sabuncuoğlu, Anıl Kırmızı, Nezih Eradamlar
OBJECTIVE: In this study, we aimed to evaluate the clinical and sociodemographic characteristics of patients with bipolar disorder who had been sent to the Forensic Psychiatry Unit by the court in order to determine factors that affected the decision to appoint a legal representative. METHODS: The reports of health council, follow-up outpatient, and hospitalization files of a total of 78 patients with bipolar disorder who had been sent to the Department of Forensic Psychiatry Outpatient Clinic of Bakirköy Mental Health and Neurological Diseases Education and Research Hospital between 1st June 2009-31st December 2011 were examined...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28936810/phosphorylated-cxcr4-expression-has-a-positive-prognostic-impact-in-colorectal-cancer
#19
B Weixler, F Renetseder, I Facile, N Tosti, E Cremonesi, A Tampakis, T Delko, S Eppenberger-Castori, A Tzankov, G Iezzi, C Kettelhack, S D Soysal, U von Holzen, G C Spagnoli, L Terracciano, L Tornillo, Raoul A Droeser, S Däster
BACKGROUND: The CXCL12-CXCR4 chemokine axis plays an important role in cell trafficking as well as in tumor progression. In colorectal cancer (CRC), the chemokine receptor CXCR4 has been shown to be an unfavorable prognostic factor in some studies, however, the role of its activated (phosphorylated) form, pCXCR4, has not yet been evaluated. Here, we aimed to investigate the prognostic value of CXCR4 and pCXCR4 in a large cohort of CRC patients. PATIENTS AND METHODS: A tissue microarray (TMA) of 684 patient specimens of primary CRCs was analyzed by immunohistochemistry (IHC) for the expression of CXCR4 and pCXCR4 by tumor cells and tumor-infiltrating immune cells (TICs)...
September 21, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28936687/perforators-of-the-fibular-artery-and-suprafascial-network
#20
Julien Gaillard, Laurent-Marie Bourcheix, Alain-Charles Masquelet
INTRODUCTION: Soft tissue defect on lower limb can result in an intractable wound. Surgeons resort in flaps to cover these injuries. Including fascia as in the case of a fasciocutaneous flap increases survey of the flap. Rising a perforator flap avoids to sacrifice a major vessel whence the nourishing perforator artery is born. We wanted to explore suprafascial distribution of the fibular skin perforator arteries supposing possible to find out a vascular axis composed of anastomoses of the fibular perforator vessels...
September 21, 2017: Surgical and Radiologic Anatomy: SRA
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