keyword
MENU ▼
Read by QxMD icon Read
search

Oxidized hemoglobin

keyword
https://www.readbyqxmd.com/read/29778075/efficient-removal-of-dyes-from-aqueous-solutions-using-a-novel-hemoglobin-iron-oxide-composite
#1
Matthew Essandoh, Rafael A Garcia
Magnetic particles entrapped in different matrices that display high thermal stability, low toxicity, interactive functions at the surface, and high saturation magnetization are of great interest. The objective of this work was to synthesize a novel hemoglobin/iron oxide composite (Hb/Fe3 O4 ) for the removal of different dyes (indigo carmine, naphthol blue black, tartrazine, erythrosine, eriochrome black T and bromophenol blue) from aqueous solutions. The Hb/Fe3 O4 composite was characterized using scanning electron microscopy (SEM), laser diffraction particle size analysis, FT-IR spectroscopy, isoelectric point determination and thermogravimetric analysis (TGA)...
May 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29774145/evaluation-of-attenuative-effect-of-tert-butylhydroquinone-against-diazinon-induced-oxidative-stress-on-hematological-indices-in-male-wistar-rats
#2
Saman Sargazi, Hamidreza Galavi, Sadegh Zarei
Diazinon is an organophosphate toxicant that has been identified to induce oxidative stress within biological systems through altering biochemical and hematological indices, by generating free radicals while deteriorating the cellular antioxidant defense system. The present study was designed to evaluate the effectiveness of tert-butylhydroquinone (TBHQ), a synthetic food additive, in serving as an antioxidant against sub-lethal diazinon-induced oxidative stress in male Wistar rats. Animals were randomly divided into 4 groups: Control (treated with corn oil as a vehicle), diazinon (10 mg/kg/day), TBHQ (0...
June 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29766685/test-retest-reliability-of-brain-mitochondrial-cytochrome-c-oxidase-assessed-by-functional-near-infrared-spectroscopy
#3
Lisa Holper, J John Mann
Functional near-infrared spectroscopy (fNIRS) is a noninvasive method for measuring in vivo both hemodynamic and mitochondrial metabolic activities in brain cortical structures. Although the test-retest reliability of the hemodynamic measures, such as reflected by oxygenated (HbO2), deoxygenated (HHb) hemoglobin, and the tissue oxygenation index (TOI), has been previously reported to be good to excellent, the reliability of the metabolic signal indexed by oxidized cytochrome-c-oxidase (oxCCO) has not been reported...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29761558/synthesis-and-characterization-of-a-deuterium-labeled-stercobilin-a-potential-biomarker-for-autism
#4
J M Coffey, A Vadas, Y Puleo, K Lewis, G Pirone, H L Rudolph, E Helms, T D Wood, A Flynn-Charlebois
Stercobilin is an end-stage metabolite of hemoglobin, a component of red blood cells. It has been found that there is a significantly lower concentration of stercobilin in the urine of people diagnosed with Autism Spectrum Disorders (ASD), suggesting potential utility as a biomarker. In vitro, we have synthesized stercobilin from its precursor bilirubin through a reduction reaction proceeded by an oxidation reaction. In addition, we have isotopically labeled the stercobilin product with deuterium using this protocol...
May 14, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29759437/cleaning-and-sterilization-of-used-cardiac-implantable-electronic-devices-with-process-validation-the-next-hurdle-in-device-recycling
#5
Thomas C Crawford, Craig Allmendinger, Jay Snell, Kevin Weatherwax, Balasundaram Lavan, Timir S Baman, Pat Sovitch, Daniel Alyesh, Thomas Carrigan, Noah Klugman, Denis Kune, Andrew Hughey, Daniel Lautenbach, Nathan Sovitch, Karman Tandon, George Samson, Charles Newman, Sheldon Davis, Archie Brown, Brad Wasserman, Ed Goldman, Sandra L Arlinghaus, Hakan Oral, Kim A Eagle
OBJECTIVES: This study sought to develop a validated, reproducible sterilization protocol, which could be used in the reprocessing of cardiac implantable electronic devices (CIEDs). BACKGROUND: Access to cardiac CIED therapy in high-income and in low- and middle-income countries varies greatly. CIED reuse may reduce this disparity. METHODS: A cleaning and sterilization protocol was developed that includes washing CIEDs in an enzymatic detergent, screw cap and set screw replacement, brushing, inspection, and sterilization in ethylene oxide...
June 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29753146/exposure-to-acrylamide-and-the-risk-of-cardiovascular-diseases-in-the-national-health-and-nutrition-examination-survey-2003-2006
#6
Yu Zhang, Mengmeng Huang, Pan Zhuang, Jingjing Jiao, Xinyu Chen, Jun Wang, Yongning Wu
BACKGROUND: Long-term exposure to acrylamide (AA) from diet sources may induce oxidative stress and chronic inflammation. However, the association between AA exposure and the prevalence of cardiovascular diseases (CVD) remains unclear. OBJECTIVES: We aimed to examine the association between blood exposure levels of AA biomarkers and the prevalence of main types of CVD in a general population of US adults. METHODS: We analyzed the associations between AA hemoglobin biomarkers [hemoglobin adducts of acrylamide (HbAA) and glycidamide (HbGA), sum of HbAA and HbGA (HbAA+HbGA), and ratio of HbGA to HbAA (HbGA:HbAA)] and self-reported diagnosis of CVD in 8290 adults (≥20 years of age) from the National Health and Nutrition Examination Survey (NHANES) 2003-2006...
May 9, 2018: Environment International
https://www.readbyqxmd.com/read/29752896/wavelength-dependence-of-vasodilation-and-no-release-from-s-nitrosothiols-and-dinitrosyl-iron-complexes-by-far-red-near-infrared-light
#7
Agnes Keszler, Brian Lindemer, Neil Hogg, Dorothee Weihrauch, Nicole L Lohr
Far red/near infrared (R/NIR) energy is a novel therapy, but its mechanism of action is poorly characterized. Cytochrome c oxidase (Cco) of the mitochondrial electron transport chain is considered the primary photoacceptor for R/NIR to photolyze a putative heme nitrosyl in Cco to liberate free nitric oxide (NO). We previously observed R/NIR light directly liberates NO from nitrosylated hemoglobin and myoglobin, and recently suggested S-nitrosothiols (RSNO) and dinitrosyl iron complexes (DNIC) may be primary sources of R/NIR-mediated NO...
May 9, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29749404/endogenous-hepcidin-synthesis-protects-the-distal-nephron-against-hemin-and-hemoglobin-mediated-necroptosis
#8
Rachel P L van Swelm, Madelon Vos, Frank Verhoeven, Frank Thévenod, Dorine W Swinkels
Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement of the DN in Hb kidney injury was suggested by the induction of renal hepcidin synthesis (p < 0.001) in mice repeatedly injected with intravenous Hb. Moreover, the hepcidin induction was associated with a decline in urinary kidney injury markers 24p3/NGAL and KIM1, suggesting a role for hepcidin in protection against Hb kidney injury...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29748789/the-polymorphism-rs2480258-within-cyp2e1-is-associated-with-different-rates-of-acrylamide-metabolism-in-vivo-in-humans
#9
Lucia Pellè, Henrik Carlsson, Monica Cipollini, Alessandra Bonotti, Rudy Foddis, Alfonso Cristaudo, Cristina Romei, Rossella Elisei, Federica Gemignani, Margareta Törnqvist, Stefano Landi
In a recent study, we demonstrated that the variant allele of rs2480258 within intron VIII of CYP2E1 is associated with reduced levels of mRNA, protein, and enzyme activity. CYP2E1 is the most important enzyme in the metabolism of acrylamide (AA) by operating its oxidation into glycidamide (GA). AA occurs in food, is neurotoxic and classified as a probable human carcinogen. The goal of the present study was to further assess the role of rs2480258 by measuring the rate of AA > GA biotransformation in vivo...
May 10, 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29743981/induction-of-nlrp3-inflammasome-activation-by-heme-in-human-endothelial-cells
#10
Judit Erdei, Andrea Tóth, Enikő Balogh, Benard Bogonko Nyakundi, Emese Bányai, Bernhard Ryffel, György Paragh, Mario D Cordero, Viktória Jeney
Hemolytic or hemorrhagic episodes are often associated with inflammation even when infectious agents are absent suggesting that red blood cells (RBCs) release damage-associated molecular patterns (DAMPs). DAMPs activate immune and nonimmune cells through pattern recognition receptors. Heme, released from RBCs, is a DAMP and induces IL-1 β production through the activation of the nucleotide-binding domain and leucine-rich repeat-containing family and pyrin domain containing 3 (NLRP3) in macrophages; however, other cellular targets of heme-mediated inflammasome activation were not investigated...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29742788/-the-relevance-of-hemolysis-in-anesthesia-and-intensive-care-medicine
#11
Jan A Graw, David M Baron, Roland C E Francis
Hemolysis leads to an increase of circulating intravascular cell-free hemoglobin. Increased plasma concentrations of cell-free hemoglobin are relevant in critically ill patients because cell-free hemoglobin causes vasoconstriction by depletion of endothelial nitric oxide, oxidative stress, and inflammation. Furthermore, cell-free hemoglobin contributes to tissue injuries such as renal failure and intestinal mucosa damage after cardiac surgery. High concentrations of cell-free hemoglobin are associated with an increased mortality in patients with sepsis...
April 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29741558/effect-of-a-high-egg-diet-on-cardiometabolic-risk-factors-in-people-with-type-2-diabetes-the-diabetes-and-egg-diabegg-study-randomized-weight-loss-and-follow-up-phase
#12
Nicholas R Fuller, Amanda Sainsbury, Ian D Caterson, Gareth Denyer, Mackenzie Fong, James Gerofi, Chloris Leung, Namson S Lau, Kathryn H Williams, Andrzej S Januszewski, Alicia J Jenkins, Tania P Markovic
Background: Some country guidelines recommend that people with type 2 diabetes (T2D) limit their consumption of eggs and cholesterol. Our previously published 3-mo weight-maintenance study showed that a high-egg (≥12 eggs/wk) diet compared with a low-egg diet (<2 eggs/wk) did not have adverse effects on cardiometabolic risk factors in adults with T2D. Objective: The current study follows the previously published 3-mo weight-maintenance study and assessed the effects of the high-egg compared with the low-egg diets as part of a 3-mo weight-loss period, followed by a 6-mo follow-up period for a total duration of 12 mo...
May 7, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29740581/effects-of-laser-radiation-on-mitochondria-and-mitochondrial-proteins-subjected-to-nitric-oxide
#13
REVIEW
Anatoly N Osipov, Tatiana V Machneva, Evgeny A Buravlev, Yury A Vladimirov
The biological roles of heme and nonheme nitrosyl complexes in physiological and pathophysiological conditions as metabolic key players are considered in this study. Two main physiological functions of protein nitrosyl complexes are discussed-(1) a depot and potential source of free nitric oxide (NO) and (2) a controller of crucial metabolic processes. The first function is realized through the photolysis of nitrosyl complexes (of hemoglobin, cytochrome c , or mitochondrial iron-sulfur proteins). This reaction produces free NO and subsequent events are due to the NO physiological functions...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29739949/hemoglobin-levels-modulate-nitrite-toxicity-to-daphnia-magna
#14
Stephanie A Eytcheson, Gerald A LeBlanc
Nitrogenous compounds enter the environment through various anthropogenic sources. Among these are nitrate (NO3 - ) and nitrite (NO2 - ) which can oxidize the heme moiety of hemoglobin and reduce the oxygen-carrying capacity of the molecule resulting in toxicity. Of the two anions, nitrite is more toxic. Hemoglobin levels are influenced by environmental conditions; thus, we hypothesized that hemoglobin levels would influence the toxicity of nitrite with low hemoglobin levels resulting in enhanced toxicity and high hemoglobin levels resulting in reduced toxicity...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29726019/speed-modulation-of-the-heartware-hvad-to-assess-in-vitro-hemocompatibility-of-pulsatile-and-continuous-flow-regimes-in-a-rotary-blood-pump
#15
Jarod T Horobin, Michael J Simmonds, Deepika Nandakumar, Shaun D Gregory, Geoff Tansley, Jo P Pauls, Angela Girnghuber, Nicoletta Balletti, John F Fraser
Although rotary blood pumps (RBPs) sustain life, blood exposure to continuous supra-physiological shear stress induces adverse effects (e.g., thromboembolism); thus, pulsatile flow in RBPs represents a potential solution. The present study introduced pulsatile flow to the HeartWare HVAD using a custom-built controller and compared hemocompatibility biomarkers (i.e., platelet aggregation, concentrations for ADAMTS13, von Willebrand factor (vWf), and free-hemoglobin in plasma (pfHb), red blood cell (RBC) deformability, and RBC-nitric oxide synthase (NOS) activity) between continuous and pulsatile flow in a blood circulation loop over 5 h...
May 3, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29720595/cytoglobin-affects-tumorigenesis-and-the-expression-of-ulcerative-colitis-associated-genes-under-chemically-induced-colitis-in-mice
#16
Mohammad Yassin, Hannelouise Kissow, Ben Vainer, Philomeena Daphne Joseph, Anders Hay-Schmidt, Jørgen Olsen, Anders Elm Pedersen
Cytoglobin (Cygb) is a member of the hemoglobin family and is thought to protect against cellular hypoxia and oxidative stress. These functions may be particularly important in inflammation-induced cancer, e.g., in patients with ulcerative colitis (UC). In this study, we investigated the development of inflammation and tumors in a murine model of inflammation-induced colorectal cancer using a combined treatment of azoxymethane and dextran sulfate sodium. A bioinformatics analysis of genome-wide expression data revealed increased colonic inflammation at the molecular level accompanied by enhanced macroscopic tumor development in Cygb-deficient mice...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29719493/effects-of-hydroxytyrosol-dose-on-the-redox-status-of-exercised-rats-the-role-of-hydroxytyrosol-in-exercise-performance
#17
Saad Al Fazazi, Rafael A Casuso, Jerónimo Aragón-Vela, Cristina Casals, Jesús R Huertas
Background: Hydroxytyrosol (HT) is a polyphenol found in olive oil that is known for its antioxidant effects. Here, we aimed to describe the effects of a low and high HT dose on the physical running capacity and redox state in both sedentary and exercised rats. Methods: Male Wistar rats were allocated into 6 groups: sedentary (SED; n  = 10); SED consuming 20 mg/kg/d HT (SED20; n  = 7); SED consuming 300 mg/kg/d HT (SED300; n = 7); exercised (EXE; n = 10); EXE consuming 20 mg/kg/d HT (EXE20; n = 10) and EXE consuming 300 mg/kg/d HT (EXE300; n = 10)...
2018: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/29718659/bacteria-carried-iron-oxide-nanoparticles-for-treatment-of-anemia
#18
Victor Garcés, Alba Rodriguez-Nogales, Ana Gonzalez, Natividad Gálvez, Elena Rodriguez-Cabezas, María-Luisa García-Martín, Lucía Gutiérrez, Deyanira Rondon, Monica Olivares, Julio Galvez, Jose Dominguez-Vera
The efficiency of maghemite nanoparticles for the treatment of anemia was sensibly higher when nanoparticles were incorporated onto the probiotic bacterium Lactobacillus fermentum (MNP-bacteria) than when administrated as uncoated nanoparticles (MNP). Plasma iron and hemoglobin, intestine expression of divalent metal transporter 1 (DMT1) and duodenal cytochrome B (DcytB), as well as hepatic expression of the hormone hepcidin were fully restored to healthy levels after administration of MNP-bacteria but not of MNP...
May 2, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29715313/circulating-pentraxin-3-is-positively-associated-with-chronic-hyperglycemia-but-negatively-associated-with-plasma-aldosterone-concentration
#19
Yuichi Takashi, Minae Koga, Yoko Matsuzawa, Jun Saito, Masao Omura, Tetsuo Nishikawa
Pentraxin 3 (PTX3) is reported to be a vascular inflammation marker providing prognostic information of vasculopathy. Until today, however, the effect of aldosterone or oxidative stress on the regulation of PTX3 is unknown. In present study, we investigated to find regulative factors, especially aldosterone and oxidative stress, on PTX3. Serum PTX3 levels were measured in 75 patients (45 male and 30 women, aged 55.1±13.4 year-old (mean±SD)) with various endocrine disorders including 47 with diabetes, 24 with primary aldosteronism (PA)...
2018: PloS One
https://www.readbyqxmd.com/read/29709913/protective-effect-of-ipragliflozin-on-pancreatic-islet-cells-in-obese-type-2-diabetic-db-db-mice
#20
Toshiyuki Takasu, Shoji Takakura
Ipragliflozin is a selective sodium glucose cotransporter 2 (SGLT2) inhibitor that increases urinary glucose excretion and subsequently improves hyperglycemia in patients with type 2 diabetes mellitus (T2DM). To assess the beneficial effect of ipragliflozin on the mass and function of pancreatic β-cells under diabetic conditions, obese T2DM db/db mice were treated with ipragliflozin for 5 weeks. Glucose and lipid metabolism parameters, pathological changes in pancreatic islet cells and insulin content were evaluated...
2018: Biological & Pharmaceutical Bulletin
keyword
keyword
107296
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"