keyword
MENU ▼
Read by QxMD icon Read
search

Oxidized hemoglobin

keyword
https://www.readbyqxmd.com/read/28087341/lung-diffusing-capacity-in-sub-saharan-africans-versus-european-caucasians
#1
Bamodi Simaga, Kevin Forton, Yoshiki Motoji, Robert Naeije, Vitalie Faoro
Single breath measurements of lung diffusing capacity (DL) for carbon monoxide (CO) and nitric oxide (NO) were performed in age-, sex-, weight- and height-matched 32 Sub-Saharan Africans (13 women) and 32 Caucasian Europeans, and repeated in 14 of each group at 80% of maximum exercise capacity. In Africans versus Caucasians respectively, DLNO was 153±31 vs 176±38ml/mmHg/min at rest (P<0.001) and 210±48 vs 241±52ml/mmHg/min at exercise (P<0.01) while hemoglobin-adjusted DLCO was 29±6 vs 34±6ml/mmHg/min at rest (P<0...
January 10, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28077358/biological-signaling-by-carbon-monoxide-and-carbon-monoxide-releasing-molecules-co-rms
#2
Roberto Motterlini, Roberta Foresti
Carbon monoxide (CO) is continuously produced in mammalian cells during degradation of heme. It is a stable gaseous molecule that reacts selectively with transition metals in a specific redox state and these characteristics restrict the interaction of CO with defined biological targets that transduce its signaling activity. Because of the high affinity of CO for ferrous heme, these targets can be grouped into heme-containing proteins, representing a large variety of sensors and enzymes with a series of diverse function in the cell and the organism...
January 11, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28072536/role-of-ionic-strength-and-ph-in-modulating-thermodynamic-profiles-associated-with-co-escape-from-rice-nonsymbiotic-hemoglobin-1
#3
David Butcher, Sophie Bernad, Valerie Derrien, Pierre Sebban, Jaroslava Miksovska
Type 1 nonsymbiotic hemoglobins are found in a wide variety of land plants and exhibit very high affinities for exogenous gaseous ligands. These proteins are presumed to have a role in protecting plant cells from oxidative stress under etiolated/hypoxic conditions through NO dioxygenase activity. In this study we have employed photoacoustic calorimetry, time-resolved absorption spectroscopy, and classical molecular dynamics simulations in order to elucidate thermodynamics, kinetics, and ligand migration pathways upon CO photodissociation from WT and a H73L mutant of type 1 nonsymbiotic hemoglobin from Oryza sativa (rice)...
January 10, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28070531/are-serum-levels-of-f2-isoprostane-and-oxidized-ldl-related-to-vitamin-d-status-in-type-2-diabetic-patients-a-case-control-study
#4
Javanbakht Mohammad Hassan, Mohammady Hamed, Fooladsaz Koorosh, Razzaghi Maryam, Zarei Mahnaz, Djalali Mahmoud
BACKGROUND: Considerable evidence suggests that oxidative stress affects diabetes mellitus (DM) and contributes to its complications. Vitamin D has been shown to possess antioxidant properties. The aim of this study was to determine the association between serum levels of calcifediol (25-OH-D), an indicator of vitamin D status, and lipid profiles with oxidative stress in patients with type 2 diabetes mellitus (T2DM). METHODS: In this case-control study, 57 T2DM patients with low vitamin D status (< 30 ng/mL) and 48 T2DM patients with normal vitamin D status (> 30 ng/mL) were enrolled...
October 2016: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28070238/hematological-disorders-and-pulmonary-hypertension
#5
REVIEW
Rajamma Mathew, Jing Huang, Joseph M Wu, John T Fallon, Michael H Gewitz
Pulmonary hypertension (PH), a serious disorder with a high morbidity and mortality rate, is known to occur in a number of unrelated systemic diseases. Several hematological disorders such as sickle cell disease, thalassemia and myeloproliferative diseases develop PH which worsens the prognosis. Associated oxidant injury and vascular inflammation cause endothelial damage and dysfunction. Pulmonary vascular endothelial damage/dysfunction is an early event in PH resulting in the loss of vascular reactivity, activation of proliferative and antiapoptotic pathways leading to vascular remodeling, elevated pulmonary artery pressure, right ventricular hypertrophy and premature death...
December 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/28069451/determination-of-extinction-coefficients-of-human-hemoglobin-in-various-redox-states
#6
Fantao Meng, Abdu I Alayash
The role of hemoglobin (Hb) redox forms in tissue and organ toxicities remain ambiguous despite the well-documented contribution of Hb redox reactivity to cellular and subcellular oxidative changes. Moreover, several recent studies, in which Hb toxicity were investigated, have shown conflicting outcomes. Uncertainties over the potential role of these species may in part be due to the protein preparation method of choice, the use of published extinction coefficients and the lack of suitable controls for Hb oxidation and heme loss...
January 6, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28065651/nitrate-reductase-regulates-plant-nitric-oxide-homeostasis
#7
REVIEW
Alejandro Chamizo-Ampudia, Emanuel Sanz-Luque, Angel Llamas, Aurora Galvan, Emilio Fernandez
Nitrate reductase (NR) is a key enzyme for nitrogen acquisition by plants, algae, yeasts, and fungi. Nitrate, its main substrate, is required for signaling and is widely distributed in diverse tissues in plants. In addition, NR has been proposed as an important enzymatic source of nitric oxide (NO). Recently, NR has been shown to play a role in NO homeostasis by supplying electrons from NAD(P)H through its diaphorase/dehydrogenase domain both to a truncated hemoglobin THB1, which scavenges NO by its dioxygenase activity, and to the molybdoenzyme NO-forming nitrite reductase (NOFNiR) that is responsible for NO synthesis from nitrite...
January 5, 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28063007/oxygen-exchange-and-energy-metabolism-in-erythrocytes-of-rett-syndrome-and-their-relationships-with-respiratory-alterations
#8
Chiara Ciaccio, Donato Di Pierro, Diego Sbardella, Grazia Raffaella Tundo, Paolo Curatolo, Cinzia Galasso, Marta Elena Santarone, Maurizio Casasco, Paola Cozza, Alessio Cortelazzo, Marcello Rossi, Claudio De Felice, Joussef Hayek, Massimo Coletta, Stefano Marini
Rett syndrome (RTT) is a neurodevelopmental disorder, mainly affecting females, which is associated to a mutation on the methyl-CpG-binding protein 2 gene. In the pathogenesis and progression of classic RTT, red blood cell (RBC) morphology has been shown to be an important biosensor for redox imbalance and chronic hypoxemia. Here we have evaluated the impact of oxidation and redox imbalance on several functional properties of RTT erythrocytes. In particular, we report for the first time a stopped-flow measurement of the kinetics of oxygen release by RBCs and the analysis of the intrinsic affinity of the hemoglobin (Hb)...
January 7, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28054978/hemoglobin-based-blood-substitutes-and-the-treatment-of-sickle-cell-disease-more-harm-than-help
#9
REVIEW
Abdu I Alayash
Intense efforts have been made by both industry and academia over the last three decades to produce viable hemoglobin (Hb)-based oxygen carriers (HBOCs), also known as "blood substitutes". Human trials conducted so far by several manufactures in a variety of clinical indications, including trauma, and elective surgeries have failed and no product has gained the Food and Drug Administration approval for human use. Safety concerns due to frequent incidences of hemodynamic, cardiac events, and even death led to the termination of some of these trials...
January 4, 2017: Biomolecules
https://www.readbyqxmd.com/read/28051246/in-vitro-antioxidant-and-antihemolytic-effects-of-the-essential-oil-and-methanolic-extract-of-allium-rotundum-l
#10
S Assadpour, S M Nabavi, S F Nabavi, A A Dehpour, M A Ebrahimzadeh
OBJECTIVE: A plethora of scientific evidence showed that several plant species from the genus Allium (Alliaceae) possess multiple therapeutic effects. Present paper aimed to examine the antioxidant and antihemolytic activities of the essential oil and methanol extract Allium rotundum L. through different in vitro assays. MATERIALS AND METHODS: 1,1-diphenyl-2-picryl hydroxyl radical (DPPH), nitric oxide as well as hydrogen peroxide scavenging, Fe2+ chelating, reducing power and also hemoglobin-induced linoleic acid peroxidation assay systems have been utilized to examine antioxidant effects of these samples...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28049107/electrochemical-sensor-based-on-magnetic-molecularly-imprinted-nanoparticles-modified-magnetic-electrode-for-determination-of-hb
#11
Binghua Sun, Xinjiong Ni, Yuhua Cao, Guangqun Cao
A fast and selective electrochemical sensor for determination of hemoglobin (Hb) was developed based on magnetic molecularly imprinted nanoparticles modified on the magnetic glassy carbon electrode. The nanoparticles Fe3O4@SiO2 with a magnetic core and a molecularly imprinted shell had regular structures and good monodispersity. Hb could be determined directly by electrochemical oxidization with the modified electrode. A magnetic field increased electrochemical response to Hb by two times. Imprinting Hb on the surface of Fe3O4@SiO2 shortened the response time within 7min...
December 28, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28034322/copolymerization-of-recombinant-phascolopsis-gouldii-hemerythrin-with-human-serum-albumin-for-use-in-blood-substitutes
#12
Mariann Arkosi, Florina Scurtu, Adriana Vulpoi, Radu Silaghi-Dumitrescu, Donald Kurtz
Hemerythrin is an oxygen-carrying protein found in marine invertebrates and may be a promising alternative to hemoglobin for use in blood substitutes, primarily due to its negligible peroxidative toxicity. Previous studies have shown that glutaraldehyde-induced copolymerization of hemoglobin with bovine serum albumin increases the half-life of the active oxy form of hemoglobin (i.e. decreases the auto-oxidation rate). Here, we describe a protocol for glutaraldehyde copolymerization of Hr with human serum albumin and the dioxygen-binding properties of the co-polymerized products...
December 30, 2016: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28032976/the-dynamics-of-lysine-as-a-heme-axial-ligand-nmr-analysis-of-the-chlamydomonas-reinhardtii-hemoglobin-thb1
#13
Matthew R Preimesberger, Ananya Majumdar, Juliette T J Lecomte
Nitrate metabolism in Chlamydomonas reinhardtii involves THB1, a monomeric hemoglobin thought to function as a nitric oxide dioxygenase (NOD). NOD activity requires dioxygen and nitric oxide binding followed by a one-electron oxidation of the heme iron and nitrate release. Unlike pentacoordinate flavohemoglobins, which are efficient NODs, THB1 uses two iron axial ligands: the conserved proximal histidine and a distal lysine (Lys53). As a ligand in both the oxidized (ferric) and reduced (ferrous) states, Lys53 is expected to lower the reorganization energy associated with electron transfer and therefore facilitate reduction of the ferric enzyme...
December 29, 2016: Biochemistry
https://www.readbyqxmd.com/read/28019031/pathogen-inactivation-by-riboflavin-and-ultraviolet-light-illumination-accelerates-the-red-blood-cell-storage-lesion-and-promotes-eryptosis
#14
Syed M Qadri, Deborah Chen, Peter Schubert, Darian L Perruzza, Varsha Bhakta, Dana V Devine, William P Sheffield
BACKGROUND: Pathogen reduction treatment using riboflavin and ultraviolet light illumination (Mirasol) effectively reduces the risk of transfusion-transmitted infections. This treatment is currently licensed for only platelets and plasma products, while its application to whole blood (WB) to generate pathogen-inactivated red blood cells (RBCs) is under development. RBC storage lesion, constituting numerous morphologic and biochemical changes, influences RBC quality and limits shelf life...
December 26, 2016: Transfusion
https://www.readbyqxmd.com/read/28013471/inflammation-and-oxidation-do-they-improve-after-kidney-transplantation-relationship-with-mortality-after-transplantation
#15
Laura Cañas, Eva Iglesias, María Cruz Pastor, Jaume Barallat, Javier Juega, Ioana Bancu, Ricardo Lauzurica
: Patients with chronic kidney disease (CKD) are characterized by a state of inflammation and oxidative stress that seems to improve after kidney transplantation (KT). Nevertheless, there is controversy regarding what is the best marker that better define inflammation and specially oxidative stress. OBJECTIVE: To evaluate the biomarkers which are associated with improvements in inflammation and lipid peroxidation in patients who have undergone KT. To evaluate the relationship between inflammation, lipid peroxidation and mortality in KT...
December 24, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/28013165/in-vitro-cytotoxicity-evaluation-of-graphene-oxide-from-the-peroxidase-like-activity-perspective
#16
Wei Zhang, Ying Sun, Zhichao Lou, Lina Song, Yang Wu, Ning Gu, Yu Zhang
In this study, PEGylated graphene oxide (PEG-GO)-hemin composite structure was constructed. Hemin in the form of nanoscaled aggregates were immobilized on PEG-GO sheets by the π-π stacking super-molecular interaction. Via catalyzing the oxidation of chromogenic substrates, we elicited the obtained PEG-GO-Hemin composite sheets have much higher peroxidase-like activity compared to hemin or PEG-GO alone, which is due to the introduction of enzyme active center of hemin with high dispersity, the excellent affinity to organic substrate through π-π stacking and/or electrostatic adsorption and the rapid electron transfer capability of PEG-GO...
December 19, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28013060/the-blood-transfer-conductance-for-nitric-oxide-infinite-vs-finite-%C3%AE-no
#17
Kirsten E Coffman, Steven C Chase, Bryan J Taylor, Bruce D Johnson
Whether the specific blood transfer conductance for nitric oxide (NO) with hemoglobin (θNO) is finite or infinite is controversial but important in the calculation of alveolar capillary membrane conductance (DmCO) and pulmonary capillary blood volume (VC) from values of lung diffusing capacity for carbon monoxide (DLCO) and nitric oxide (DLNO). In this review, we discuss the background associated with θNO, explore the resulting values of DmCO and VC when applying either assumption, and investigate the mathematical underpinnings of DmCO and VC calculations...
December 21, 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28008565/broadband-near-infrared-spectroscopy-can-detect-cyanide-induced-cytochrome-aa3-inhibition-in-rats-a-proof-of-concept-study
#18
Robert H Thiele, Keita Ikeda, Yunzhen Wang, Raquel R Bartz, Zhiyi Zuo
PURPOSE: Clinically available near-infrared spectroscopy (NIRS) devices use two to five wavelengths of light to measure the relative amounts of oxyhemoglobin and deoxyhemoglobin in tissue to determine tissue hemoglobin oxygen saturation (StO2). In addition to StO2, broadband NIRS devices (using hundreds of wavelengths of light) may be able to measure the oxidation state of mitochondrial cytochrome aa3 (Cytox) which reflects the subcellular energetic state. We hypothesize that broadband NIRS devices can measure Cytox independent of changes in hemoglobin saturation...
December 22, 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/28007575/the-mechanism-of-formation-structure-and-physiological-relevance-of-covalent-hemoglobin-attachment-to-the-erythrocyte-membrane
#19
Elizabeth M Welbourn, Michael T Wilson, Ashril Yusof, Metodi V Metodiev, Chris E Cooper
Covalent hemoglobin binding to membranes leads to band 3 (AE1) clustering and the removal of erythrocytes from the circulation; it is also implicated in blood storage lesions. Damaged hemoglobin, with the heme being in a redox and oxygen-binding inactive hemichrome form, has been implicated as the binding species. However, previous studies used strong non-physiological oxidants. In vivo hemoglobin is constantly being oxidised to methemoglobin (ferric), with around 1% of hemoglobin being in this form at any one time...
December 20, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28003847/in-vitro-protective-effect-of-phikud-navakot-extraction-on-erythrocyte
#20
Kanchana Kengkoom, Sumate Ampawong
Phikud Navakot (PN), Thai herbal remedy in National List of Essential Medicines, has been claimed to reduce many cardiovascular symptoms especially dizziness and fainting. Apart from blood supply, erythrocyte morphology, in both shape and size, is one of the main consideration factors in cardiovascular diseases and may be affected by vascular oxidative stress. However, little is known about antioxidative property of PN on erythrocyte to preserve red blood cell integrity. In this study, 1,000 μM hydrogen peroxide-induced oxidative stress was conducted on sheep erythrocyte...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
keyword
keyword
107296
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"