keyword
MENU ▼
Read by QxMD icon Read
search

Oxidized hemoglobin

keyword
https://www.readbyqxmd.com/read/29324291/disulfide-masked-iron-prochelators-effects-on-cell-death-proliferation-and-hemoglobin-production
#1
E A Akam, R D Utterback, J R Marcero, H A Dailey, E Tomat
The iron metabolism of malignant cells, which is altered to ensure higher acquisition and utilization, motivates the investigation of iron chelation strategies in cancer treatment. In a prochelation approach aimed at increasing intracellular specificity, disulfide reduction/activation switches are incorporated on iron-binding scaffolds resulting in intracellularly activated scavengers. Herein, this strategy is applied to several tridentate donor sets including thiosemicarbazones, aroylhydrazones and semicarbazones...
January 4, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29323037/bone-marrow-derived-mesenchymal-stem-cells-ameliorate-sodium-nitrite-induced-hypoxic-brain-injury-in-a-rat-model
#2
Elham H A Ali, Omar A Ahmed-Farid, Amany A E Osman
Sodium nitrite (NaNO2) is an inorganic salt used broadly in chemical industry. NaNO2 is highly reactive with hemoglobin causing hypoxia. Mesenchymal stem cells (MSCs) are capable of differentiating into a variety of tissue specific cells and MSC therapy is a potential method for improving brain functions. This work aims to investigate the possible therapeutic role of bone marrow-derived MSCs against NaNO2 induced hypoxic brain injury. Rats were divided into control group (treated for 3 or 6 weeks), hypoxic (HP) group (subcutaneous injection of 35 mg/kg NaNO2 for 3 weeks to induce hypoxic brain injury), HP recovery groups N-2wR and N-3wR (treated with the same dose of NaNO2 for 2 and 3 weeks respectively, followed by 4-week or 3-week self-recovery respectively), and MSCs treated groups N-2wSC and N-3wSC (treated with the same dose of NaNO2 for 2 and 3 weeks respectively, followed by one injection of 2 × 106 MSCs via the tail vein in combination with 4 week self-recovery or intravenous injection of NaNO2 for 1 week in combination with 3 week self-recovery)...
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29318368/increased-levels-of-advanced-glycation-end-products-positively-correlate-with-iron-overload-and-oxidative-stress-markers-in-patients-with-%C3%AE-thalassemia-major
#3
Maryam Sadat Mirlohi, Hamid Yaghooti, Saeed Shirali, Ali Aminasnafi, Samaneh Olapour
The impaired biosynthesis of the β-globin chain in β-thalassemia leads to the accumulation of unpaired alpha globin chains, failure in hemoglobin formation, and iron overload due to frequent blood transfusion. Iron excess causes oxidative stress and massive tissue injuries. Advanced glycation end products (AGEs) are harmful agents, and their production accelerates in oxidative conditions. This study was conducted on 45 patients with major β-thalassemia who received frequent blood transfusions and chelation therapy and were compared to 40 healthy subjects...
January 9, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29313031/direct-comparison-of-oligochaete-erythrocruorins-as-potential-blood-substitutes
#4
Devon Zimmerman, Matthew DiIusto, Jack Dienes, Osheiza Abdulmalik, Jacob J Elmer
While many blood substitutes are based on mammalian hemoglobins (e.g., human hemoglobin, HbA), the naturally extracellular hemoglobins of invertebrates (a.k.a. erythrocruorins, Ecs) are intriguing alternative oxygen carriers. Specifically, the erythrocruorin of Lumbricus terrestris has been shown to effectively deliver oxygen in mice and rats without the negative side effects observed with HbA. In this study, the properties of six oligochaete Ecs (Lumbricus terrestris, Eisenia hortensis, Eisenia fetida, Eisenia veneta, Eudrilus eugeniae, and Amynthas gracilis) were compared in vitro to identify the most promising blood substitute candidate(s)...
June 2017: Bioengineering & Translational Medicine
https://www.readbyqxmd.com/read/29311486/effect-of-seleno-l-methionine-on-oxidative-stress-in-the-pancreatic-islets-of-a-short-term-induced-diabetic-mouse-model-in-insufficient-selenium-status
#5
Hitoshi Ueno, Ryo Shimizu, Tomofumi Okuno, Hirofumi Ogino, Tomohiro Arakawa, Koichi Murano, Katsuhiko Nakamuro
The protective effects of seleno-L-methionine (SeMet) on oxidative stress in pancreatic islets were investigated with a short-term nicotinamide (NA) and streptozotocin (STZ)-induced diabetic mouse model. ICR mice were intraperitoneally injected twice with 100 mg/kg STZ and 120 mg/kg NA at a 1-d interval and were then orally administered 158 µg Se/kg SeMet with free access to a selenium-deficient diet for 5 weeks. Administration of SeMet significantly improved the levels of glycated hemoglobin (HbA1c), non-fasting and oral glucose tolerance-tested (OGTT) blood glucose, plasma adiponectin and hepatic glycogen that deteriorated by NA/STZ treatment...
2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29305332/morphological-and-functional-characterization-of-hemocytes-from-two-deep-sea-vesicomyid-clams-phreagena-okutanii-and-abyssogena-phaseoliformis
#6
Akihiro Tame, Genki Ozawa, Tadashi Maruyama, Takao Yoshida
Deep-sea vesicomyid clams harboring intracellular symbiotic sulfur-oxidizing bacteria are often dominant in chemosynthetic animal communities. Although they are known to have erythrocytes, little is known about other hemocytes. To investigate the types and roles of various hemocytes in vesicomyid clams, we performed morphological, histochemical and functional characterization of the hemocytes in two species, Phreagena okutanii, collected from 873 to 978 m depth, and Abyssogena phaseoliformis, from 5199 to 5355 m...
January 2, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29305213/interaction-of-glossoscolex-paulistus-extracellular-hemoglobin-with-hydrogen-peroxide-formation-and-decay-of-ferryl-hbgp
#7
Silvia H Libardi, Fernanda R Alves, Marcel Tabak
The giant extracellular hemoglobin from earthworm Glossoscolex paulistus (HbGp) reacts with hydrogen peroxide, displaying peroxidase activity in the presence of guaiacol. The formation of ferryl-HbGp (compound II) from the peroxidase cycle was studied in the present work. The hypervalent ferryl-HbGp species was formed directly by the reaction of oxy-HbGp and hydrogen peroxide. The oxy-HbGp heme groups (144) under different excess of H2O2, relative to heme, showed an influence in the total amount of ferryl-HbGp at the end of the reaction...
January 2, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29302655/iron-reduction-response-and-demographic-differences-between-diabetics-and-non-diabetics-with-cardiovascular-disease-entered-into-a-controlled-clinical-trial
#8
Leo R Zacharski, Galina Shamayeva, Bruce K Chow
Iron-catalyzed oxygen-free radical-induced oxidative stress mediates the pathogenesis of diabetes and cardiovascular disease (CVD). Diabetics (n = 473) and non-diabetics (n = 804) with CVD entered into a randomized trial of iron (ferritin) reduction by calibrated phlebotomy (, Identifier NCT00032357) had comparable iron measures at entry but diabetics had a greater burden of CVD and comorbidities, lower hemoglobin and hematocrit levels, and higher glucose levels than non-diabetics. Entry iron measures were lower in diabetics on hypoglycemic therapy compared to previously untreated diabetics...
January 5, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29298491/is-mri-detection-of-kidney-iron-deposition-increased-in-haptoglobin-2-2-genotype-carriers-with-type-1-diabetes
#9
Tina Costacou, Trevor J Orchard, Chan-Hong Moon, Kyongtae T Bae, Linda F Fried, Rhobert W Evans
Haptoglobin's (Hp) main role is to bind free hemoglobin (Hb), reducing its oxidative potential. The Hp-Hb complex formed is cleared from the circulation by macrophage receptor CD163. In diabetes, impaired Hp 2-2 - Hb CD163 clearance and abnormal glomerular permeability allow the large Hp 2-2 - Hb complex to cross the barrier, where its redox active iron leads to cellular toxicity. Although Hp 2-2 predicts renal function decline, whether renal iron deposition differs by Hp is unknown. We used renal quantitative T2* magnetic resonance imaging to estimate iron level in the cortex and medullar of type 1 diabetes adults (15 Hp 1-1 and 15 Hp 2-2 carriers of similar age (53 yrs), duration (45 yrs) and sex)...
January 3, 2018: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29297132/assessment-of-biomarkers-in-the-neotropical-fish-brycon-amazonicus-exposed-to-cypermethrin-based-insecticide
#10
Fernanda Dias de Moraes, Francine Perri Venturini, Priscila Adriana Rossi, Ive Marchioni Avilez, Naiara Elisabete da Silva de Souza, Gilberto Moraes
The effects of cypermethrin-based insecticide (CBI), commonly used in aquaculture and agriculture, were evaluated in matrinxa (Brycon amazonicus) exposed to sub-lethal concentration (20% of LC50) for 96 h. Physiological and biochemical effects were studied through biomarkers: lipid peroxidation (LPO), glutathione (GSH), and ascorbic acid concentrations; superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glucose-6-phosphate dehydrogenase (G6PDH) assays in the liver and gills. Besides, ions Na+, Cl-, and K+; protein and glucose concentrations were measured in the plasma...
January 2, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29284479/acacia-hydaspica-r-parker-prevents-doxorubicin-induced-cardiac-injury-by-attenuation-of-oxidative-stress-and-structural-cardiomyocyte-alterations-in-rats
#11
Tayyaba Afsar, Suhail Razak, Khalid Mujasam Batoo, Muhammad Rashid Khan
BACKGROUND: The use of doxorubicin (DOX) an anthracycline antineoplastic agent is withdrawn due to its cardio-toxic side effects. Oxidative stress has been recognized as the primary cause of DOX induced cardiotoxicity. We have investigated whether polyphenol rich ethyl acetate extract of Acacia hydaspica (AHE) can attenuate doxorubicin-induced cardiotoxicity via inhibition of oxidative stress. METHODS: AHE was administered orally to rats once daily for 6 weeks at doses of 200 and 400 mg/kg b...
December 29, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29281195/physiological-responses-to-prolonged-saturation-diving-a-field-based-pilot-study
#12
Sanjoy Deb, Katherine Burgess, Paul Swinton, Eimear Dolan
This study aimed to assess the effect of extreme environmental exposure during an operational saturation dive on airway inflammation (exhaled nitric oxide (FeNo)), components of fitness (flexibility and aerobic capacity) and blood hematological variables. Six saturation divers, who undertook a 26±0.5 day operational saturation dive were recruited to take part in this study. Participants completed a field-based repeated measure test battery on three occasions (pre-dive, post-dive and 24 hours after saturation dive)...
November 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/29258784/methemoglobinemia-in-a-case-of-paint-thinner-intoxication-treated-successfully-with-vitamin-c
#13
Deba Prasad Dhibar, Kamal Kant Sahu, Sanjay Jain, Savita Kumari, Subhash Chander Varma
BACKGROUND: Methemoglobin (MetHb) is an oxidized form of hemoglobin. It is a poor transporter of oxygen and is unable to deliver oxygen to the tissue. Globally, drug & toxin induced methemoglobinemia is more common as compared with the congenital form. Methemoglobinemia caused by paint thinner intoxication is rare. Methylene blue is well established as the first-line therapy for severe methemoglobinemia. CASE REPORT: A 25-year old man was brought to the Emergency Department after accidental consumption of paint thinner...
December 16, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29251613/-participation-of-melatonin-in-regulation-of-blood-oxygen-transport-function-in-oxidative-stress-induced-by-injection-of-lipopolisaccharide
#14
V V Zinchuk, M E Firago
The contribution of melatonin to the regulatoin of the blood oxygen transport function was studied during oxidative stress induced by a triple injection of lipopolysaccharide (at a dose of 5 mg/kg) in conditions of erythropoietin and gasetransmitters (nitrogen monoxide, hydrogen sulfide) action. In the experimental groups, intraperitoneal injections of melatonin (5 mg/kg), erythropoietin (1000 U/kg), hydrogen sulfide donor (NaHS 5 mg/kg), and L-arginine (100 mg/kg), were performed. The use of melatonin alone or in combination with erythropoietin, sodium hydrosulfide or L-arginine led to a decrease in lipid peroxidation products and an increase in the antioxidant protection...
November 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29247447/relationships-of-oxidized-hdl-with-blood-coagulation-and-fibrinolysis-in-patients-with-type-2-diabetes-mellitus
#15
Shigeyuki Ebara, Mikio Marumo, Jun Mukai, Makoto Ohki, Kagehiro Uchida, Ichiro Wakabayashi
Although oxidization of LDL is known to be a crucial step for atherosclerotic progression, the significance of oxidized HDL remains to be clarified. The purpose of this study was to determine the relationships of oxidized HDL with blood coagulation and fibrinolysis in patients with diabetes. The subjects were outpatients with type 2 diabetes (n = 163; median hemoglobin A1c, 6.9%). Activities of blood coagulation and fibrinolysis were evaluated by levels of thrombin-anti-thrombin complex (TAT) and plasmin-α2 plasmin inhibitor complex (PIC), respectively...
December 15, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29246762/hemoglobin-crystals-immersed-in-liquid-oxygen-reveal-diffusion-channels
#16
James Ross Terrell, Ryan H Gumpper, Ming Luo
Human hemoglobin (HbA) transports molecular oxygen (O2) from the lung to tissues where the partial pressure of O2 is lower. O2 binds to HbA at the heme cofactor and is stabilized by a distal histidine (HisE7). HisE7 has been observed to occupy opened and closed conformations, and is postulated to act as a gate controlling the binding/release of O2. However, it has been suggested that HbA also contains intraprotein oxygen channels for entrances/exits far from the heme. In this study, we developed a novel method of crystal immersion in liquid oxygen prior to X-ray data collection...
December 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29246729/a-comparison-of-the-effects-of-low-and-high-dose-atorvastatin-on-lipoprotein-metabolism-and-inflammatory-cytokines-in-type-2-diabetes-results-from-the-protection-against-nephropathy-in-diabetes-with-atorvastatin-panda-randomized-trial
#17
Handrean Soran, Yifen Liu, Safwaan Adam, Tarza Siahmansur, Jan H Ho, Jonathan D Schofield, See Kwok, Matthew Gittins, Michael France, Naveed Younis, J Martin Gibson, Paul N Durrington, Martin K Rutter
BACKGROUND: Statin therapy is recommended in type 2 diabetes (T2DM) although views on treatment intensity and therapeutic targets remain divided. OBJECTIVES: Our objectives were to compare the effects of high-intensity and moderate-intensity atorvastatin treatment on lipoprotein metabolism and inflammatory markers and how frequently treatment goals are met in high-risk T2DM patients. METHODS: Patients with T2DM and albuminuria (urinary albumin:creatinine ratio >5 mg/mmol, total cholesterol <7 mmol/L, proteinuria <2 g/d, creatinine <200 μmol/L) were randomized to receive atorvastatin 10 mg (n = 59) or 80 mg (n = 60) daily...
November 13, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29245041/stability-of-postmortem-methemoglobin-artifactual-changes-caused-by-storage-conditions
#18
Vincent Varlet, Elenore Ryser, Marc Augsburger, Cristian Palmiere
Hemoglobin is the protein in red blood cells that carries and distributes oxygen to the body. Methemoglobinemia is a blood disorder in which an abnormal amount of methemoglobin (MetHb), a form of hemoglobin (Hb), is produced from either inadequate MetHb reductase activity or too much MetHb production or by exposure to oxidizing agents. This could lead to anoxia and death if it is not treated. However, this parameter has not been investigated as a valid post-mortem indicator because random MetHb levels have been observed in various studies: MetHb increases can be observed due to autoxidation during storage, and MetHb decreases can be observed due to MetHb reductase or microbial activity in post-mortem samples...
December 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29238951/pharmacologic-targeting-of-red-blood-cells-to-improve-tissue-oxygenation
#19
James D Reynolds, Trevor Jenkins, Faisal Matto, Ryan Nazemian, Obada Farhan, Nathan Morris, John M Longphre, Douglas T Hess, Richard E Moon, Claude A Piantadosi, Jonathan S Stamler
Disruption of microvascular blood flow is a common cause of tissue hypoxia in disease, yet no therapies are available that directly target the microvasculature to improve tissue oxygenation. Red blood cells (RBCs) auto-regulate blood flow through S-nitroso-hemoglobin (SNO-Hb)-mediated export of nitric oxide (NO) bioactivity. We therefore tested the idea that pharmacological enhancement of RBCs using the S-nitrosylating agent ethyl nitrite (ENO) may provide a novel approach to improve tissue oxygenation. Serial ENO dosing was carried out in sheep (1-400 ppm) and humans (1-100 ppm) at normoxia and at reduced FiO2 ...
December 14, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29234381/antihyperglycemic-antidiabetic-and-antioxidant-effects-of-garcinia-pedunculata-in-rats
#20
Md Yousuf Ali, Sudip Paul, E M Tanvir, Md Sakib Hossen, Nur-E Noushin Rumpa, Moumoni Saha, Nikhil Chandra Bhoumik, Md Aminul Islam, Md Sabir Hossain, Nadia Alam, Siew Hua Gan, Md Ibrahim Khalil
The antihyperglycemic, antidiabetic, and antioxidant potentials of the methanolic extract of Garcinia pedunculata (GP) fruit in rats were investigated. The acute antihyperglycemic effect of different doses of GP was studied in normal male Wistar rats. Diabetes was induced by streptozotocin (STZ) injection in another cohort of male Wistar rats and they showed significantly higher blood glucose and glycated hemoglobin (HbA1c) levels, altered lipid profiles, and lower insulin levels compared to nondiabetic control animals...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
keyword
keyword
107296
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"