Shuangshuang Huo, Xiaofeng Lei, Dan He, Hua Zhang, Zhipeng Yang, Wenhua Mu, Ke Fang, Dan Xue, He Li, Xiaoyan Li, Nan Jia, Hongli Zhu, Chao Chen, Kunping Yan
Oxidative damage caused by the ferryl hemoglobin is one of the major clinical adverse reactions of hemoglobin-based oxygen carriers (HBOCs), while the production of reactive oxygen species in a pathological state can oxidize hemoglobin (HbFe2+ ) to ferryl Hb, which can then enter the pseudoperoxidase cycle, making hemoglobin highly toxic. In this study, we found that ferrous hemoglobin and polymerized porcine hemoglobin (one of the HBOCs) have the peroxidase activity different from the pseudoperoxidase activity of ferric hemoglobin...
October 2021: Artificial Organs