keyword
MENU ▼
Read by QxMD icon Read
search

Proximal tubule

keyword
https://www.readbyqxmd.com/read/29470404/oleanolic-acid-exerts-osteoprotective-effects-and-modulates-vitamin-d-metabolism
#1
Sisi Cao, Xiao-Li Dong, Ming-Xian Ho, Wen-Xuan Yu, Ka-Chun Wong, Xin-Sheng Yao, Man-Sau Wong
Oleanolic acid (OA) is a triterpenoid with reported bone anti-resorption activities. The present study aimed to characterize its bone protective effects in vivo and to study its effects on vitamin D metabolism, both in vivo and in vitro. OA significantly increased bone mineral density, improved micro-architectural properties, reduced urinary Ca excretion, increased 1,25(OH)₂D₃ and renal CYP27B1 mRNA expression in mature C57BL/6 ovariectomised (OVX) mice. OA also improved bone properties, Ca balance, and exerted modulatory effects on renal CYP27B1 and CYP24A1 expressions in aged normal female Sprague-Dawley rats...
February 22, 2018: Nutrients
https://www.readbyqxmd.com/read/29465303/morphologic-and-morphometric-study-on-microvasculature-of-developing-mouse-kidneys
#2
Jie Zhang, Jing Cong, Jie Yang, Jesper Skovhus Thomsen, Arne Andreasen, Shi-Jie Chang, Kai-Yue Wang, Ling Gu, Xiao-Yue Zhai
A proper morphogenesis of the renal microvasculature is crucial not only for fulfilling the renal function, but also to slow down the progression of chronic kidney disease in adulthood. However, the current description of the developing microvasculature is incomplete. The present study investigated the morphogenesis and volume densities of the renal microvasculature using computer-assisted tubular tracing, immunohistochemistry for CD34, and unbiased stereology. The earliest glomerular capillaries were observed at the lower cleft of the S-shape nephrons, as simple loops connecting the afferent and efferent arterioles...
February 21, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29461614/mitochondria-mediated-disturbance-of-fatty-acid-metabolism-in-proximal-tubule-epithelial-cells-leads-to-renal-interstitial-fibrosis
#3
W Shen, X-X Jiang, Y-W Li, Q He
OBJECTIVE: To investigate the role of mitochondria-mediated fatty acid metabolism in proximal tubule cells in renal interstitial fibrosis. MATERIALS AND METHODS: Intraperitoneal injection of folate was performed to induce renal interstitial fibrosis in mice. Polymerase chain reaction (PCR) was used to detect the expression of cytochrome c oxidase subunit IV (COX4IL) and phosphoenolpyruvate carboxykinase 1 (PCK1) in samples. Electron microscope was used to detect the activity of mitochondria...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29461599/microvesicles-containing-microrna-21-secreted-by-proximal-tubular-epithelial-cells-are-involved-in-renal-interstitial-fibrosis-by-activating-akt-pathway
#4
S-B Zheng, Y Zheng, L-W Jin, Z-H Zhou, Z-Y Li
OBJECTIVE: To investigate the role of microvesicles containing microRNA-21 in renal interstitial fibrosis and its possible mechanism. MATERIALS AND METHODS: The renal interstitial fibrosis model was established by unilateral ureteral obstruction, and proximal tubule epithelial cell line (NRK52E) was used for cell model. The phenotype changes of the microvesicles containing microRNA-21 secreted by tubule cells during fibrosis were detected, and possible mechanisms responsible for the process were also analyzed...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29445145/canagliflozin-mediated-dual-inhibition-of-mitochondrial-glutamate-dehydrogenase-and-complex-i-an-off-target-adverse-effect
#5
Philipp F Secker, Sascha Beneke, Nadja Schlichenmaier, Johannes Delp, Simon Gutbier, Marcel Leist, Daniel R Dietrich
Recent FDA Drug Safety Communications report an increased risk for acute kidney injury in patients treated with the gliflozin class of sodium/glucose co-transport inhibitors indicated for treatment of type 2 diabetes mellitus. To identify a potential rationale for the latter, we used an in vitro human renal proximal tubule epithelial cell model system (RPTEC/TERT1), physiologically representing human renal proximal tubule function. A targeted metabolomics approach, contrasting gliflozins to inhibitors of central carbon metabolism and mitochondrial function, revealed a double mode of action for canagliflozin, but not for its analogs dapagliflozin and empagliflozin...
February 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29445029/pantoprazole-an-inhibitor-of-the-organic-cation-transporter-2-does-not-ameliorate-cisplatin-related-ototoxicity-or-nephrotoxicity-in-children-and-adolescents-with-newly-diagnosed-osteosarcoma-treated-with-methotrexate-doxorubicin-and-cisplatin
#6
Elizabeth Fox, Kristin Levin, Yan Zhu, Blair Segers, Naomi Balamuth, Richard Womer, Rochelle Bagatell, Frank Balis
LESSONS LEARNED: Using a randomized crossover design and continuous variables such as change in hearing threshold and biomarkers of acute renal injury as short-term endpoints, it was determined that pantoprazole, an organic cation transporter 2 inhibitor, did not ameliorate cisplatin-associated nephrotoxicity or ototoxicity.Cystatin C is a robust method to estimate glomerular filtration rate in patients with cancer. Using a patient-reported outcome survey, all patients identified tinnitus and subjective hearing loss occurring "at least rarely" after cycle 1, prior to objective high-frequency hearing loss measured by audiograms...
February 14, 2018: Oncologist
https://www.readbyqxmd.com/read/29444177/kidney-differentiated-cells-derived-from-lowe-syndrome-patient-s-ipscs-show-ciliogenesis-defects-and-six2-retention-at-the-golgi-complex
#7
Wen-Chieh Hsieh, Swetha Ramadesikan, Donna Fekete, Ruben Claudio Aguilar
Lowe syndrome is an X-linked condition characterized by congenital cataracts, neurological abnormalities and kidney malfunction. This lethal disease is caused by mutations in the OCRL1 gene, which encodes for the phosphatidylinositol 5-phosphatase Ocrl1. While in the past decade we witnessed substantial progress in the identification and characterization of LS patient cellular phenotypes, many of these studies have been performed in knocked-down cell lines or patient's cells from accessible cell types such as skin fibroblasts, and not from the organs affected...
2018: PloS One
https://www.readbyqxmd.com/read/29441906/mir-130a-protects-against-lipopolysaccharide-induced-glomerular-cell-injury-by-upregulation-of-klotho
#8
Hongda Liang, Kun Yang, Miaomiao Xin, Xiangping Liu, Lei Zhao, Bin Liu, Jibo Wang
AIMS: Lupus nephritis is a frequent and serious complication of systemic lupus erythematosus (SLE). Therefore, better understanding regarding the underlying mechanism of renal tubular injury induced by SLE, is beneficial to develop different therapeutic strategies for lupus nephritis. The study aimed to investigate the role of miR-130a against lipopolysaccharide-induced glomerular cell injury. METHODS: HK-2 cells (human renal proximal tubule cells) were used for detecting miR-130a levels...
August 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441828/fluoride-associated-ultrastructural-changes-and-apoptosis-in-human-renal-tubule-a-pilot-study
#9
J A Quadri, S Sarwar, A Sinha, M Kalaivani, A K Dinda, A Bagga, T S Roy, T K Das, A Shariff
The susceptibility of the kidneys to fluoride toxicity can largely be attributed to its anatomy and function. As the filtrate moves along the complex tubular structure of each nephron, it is concentrated in the proximal and distal tubules and collecting duct. It has been frequently observed that the children suffering from renal impairments also have some symptoms of dental and skeletal fluorosis. The findings suggest that fluoride somehow interferes with renal anatomy and physiology, which may lead to renal pathogenesis...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29440005/interaction-between-the-sodium-glucose-linked-transporter-2-inhibitor-dapagliflozin-and-the-loop-diuretic-bumetanide-in-normal-human-subjects
#10
Christopher S Wilcox, Wen Shen, David W Boulton, Bruce R Leslie, Steven C Griffen
BACKGROUND: Dapagliflozin inhibits the sodium-glucose-linked transporter 2 in the renal proximal tubule, thereby promoting glycosuria to reduce hyperglycemia in type 2 diabetes mellitus. Because these patients may require loop diuretics, and sodium-glucose-linked transporter 2 inhibition causes an osmotic diuresis, we evaluated the diuretic interaction between dapagliflozin and bumetanide. METHODS AND RESULTS: Healthy subjects (n=42) receiving a fixed diet with ≈110 mmol·d -1 of Na + were randomized to bumetanide (1 mg·d -1 ), dapagliflozin (10 mg·d -1 ), or both for 7 days, followed by 7 days of both...
February 10, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29435202/podocyte-derived-microparticles-promote-proximal-tubule-fibrotic-signaling-via-p38-mapk-and-cd36
#11
Mercedes N Munkonda, Shareef Akbari, Chloe Landry, Suzy Sun, Fengxia Xiao, Maddison Turner, Chet E Holterman, Rania Nasrallah, Richard L Hébert, Christopher R J Kennedy, Dylan Burger
Tubulointerstitial fibrosis is a hallmark of advanced diabetic kidney disease that is linked to a decline in renal function, however the pathogenic mechanisms are poorly understood. Microparticles (MPs) are 100-1000 nm vesicles shed from injured cells that are implicated in intercellular signalling. Our lab recently observed the formation of MPs from podocytes and their release into urine of animal models of type 1 and 2 diabetes and in humans with type 1 diabetes. The purpose of the present study was to examine the role of podocyte MPs in tubular epithelial cell fibrotic responses...
2018: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/29430722/patients-affected-by-dent-disease-2-could-be-predisposed-to-hidradenitis-suppurativa
#12
Pierluigi Marzuillo, Vincenzo Piccolo, Massimo Mascolo, Andrea Apicella, Giuseppe Argenziano, Nicoletta Della Vecchia, Stefano Guarino, Emanuele Miraglia Del Giudice, Angela La Manna
Dent disease 2 (DD2) is a rare X-Linked disorder characterized by proximal tubule dysfunction. It is considered as mild variant of Lowe Syndrome (LS) and both conditions are secondary to OCRL1 gene mutations.1 Mutations in this gene drastically reduce (<10%) inositol polyphosphate 5-phosphatase (OCRL1) activity.1 This article is protected by copyright. All rights reserved.
February 11, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29428569/a-continuum-of-mineralization-from-human-renal-pyramid-to-stones-on-stems
#13
Benjamin A Sherer, Ling Chen, Misun Kang, Alex R Shimotake, Scott V Wiener, Tom Chi, Marshall L Stoller, Sunita P Ho
The development of new modalities for kidney stone prevention rests upon understanding the progression of mineralization within the renal pyramid. The progression from small foci of mineralization within the renal pyramid to larger interstitial plaques that ultimately lead to the formation of clinically detectable calcium-based stones on calcium phosphate stems will be presented through correlative microscopy approach. High resolution X-ray computed tomography (micro-XCT), electron microscopy, and energy dispersive X-ray (EDX) compositional analyses of interstitial plaques, stems, and attached stones were performed...
February 8, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29425694/renal-fibrosis-primacy-of-the-proximal-tubule
#14
REVIEW
Leslie S Gewin
Tubulointerstitial fibrosis (TIF) is the hallmark of chronic kidney disease and best predictor of renal survival. Many different cell types contribute to TIF progression including tubular epithelial cells, myofibroblasts, endothelia, and inflammatory cells. Previously, most of the attention has centered on myofibroblasts given their central importance in extracellular matrix production. However, emerging data focuses on how the response of the proximal tubule, a specialized epithelial segment vulnerable to injury, plays a central role in TIF progression...
February 6, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29424089/cardiovascular-benefits-of-sglt2-inhibition-in-diabetes-and-chronic-kidney-diseases
#15
EDITORIAL
Anita T Layton, Volker Vallon
In addition to being a leading cause of end-stage renal disease, diabetes mellitus is also associated with an elevated risk of heart failure. A new class of anti-hyperglycaemic drugs are the sodium-glucose cotransporter 2 (SGLT2) inhibitors, which attenuate postprandial increases in blood glucose by targeting its reabsorption along the early proximal tubule and enhancing urinary glucose excretion. Because the transport of glucose and Na+ in the proximal tubule is coupled, inhibition of SGLT2 also reduces proximal tubular Na+ and fluid reabsorption, and induces natriuresis and diuresis...
February 8, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29415819/a-new-class-of-drugs-for-heart-failure-sglt2-inhibitors-reduce-sympathetic-overactivity
#16
REVIEW
Motoaki Sano
Even in the presence of excess glucose, the proximal renal tubules continue to resorb more glucose. Sodium glucose cotransporter 2 (SGLT2) inhibitors are drugs that control this "greed" (H. Ito, Keio University, Japan). Negative feedback mechanisms maintain homeostasis for various physiological functions. However, there is no negative feedback mechanism for resorption of glucose by the proximal renal tubules. When food was scarce during human evolution, not limiting nutrient reabsorption was advantageous for survival, but the opposite is true in the era of satiation...
February 4, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29413112/expression-and-immunolocalization-of-metallothioneins-mt1-mt2-and-mt3-in-rat-nephron
#17
Ivan Sabolić, Mario Škarica, Marija Ljubojević, Davorka Breljak, Carol M Herak-Kramberger, Vladiana Crljen, Nikola Ljubešić
Rodent kidneys exhibit three isoforms of metallothioneins (MTs), MT1, MT2 and MT3, with poorly characterized localization along the nephron. Here we studied in adult male Wistar rats the renal expression of MTs mRNA by end-point RT-PCR and MT proteins by immunochemical methods The expression pattern of MT1 mRNA was cortex (CO)>outer stripe (OS)=inner stripe (IS)=inner medulla (IM), of MT2 mRNA was IM>CO>IS=OS, and of MT3 mRNA was IM>CO=OS=IM. MT1/2-antibody stained with heterogeneous intensity the cell cytoplasm and nuclei in proximal tubule (PT) and thin ascending limb, whereas MT3-antibody stained weakly the cell cytoplasm in various cortical tubules and strongly the nuclei in all nephron segments...
March 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29412698/the-organic-anion-transporter-oat3-enhances-the-glucosuric-effect-of-the-sglt2-inhibitor-empagliflozin
#18
Yiling Fu, Davorka Breljak, Akira Onishi, Falk Batz, Rohit Patel, Winnie Huang, Panai Song, Brent Freeman, Eric Mayoux, Hermann Koepsell, Naohiko Anzai, Sanjay K Nigam, Ivan Sabolić, Volker Vallon
The SGLT2 inhibitor empagliflozin (plasma protein binding ~88%) may reach its target in the brush border of the early proximal tubule by glomerular filtration and tubular secretion. Here we determined whether empagliflozin is secreted by renal tubules, and whether genetic knockout of the basolateral organic anion transporter Oat3 (-/-) affects its tubular secretion or glucosuric effect. Renal clearance studies in wild-type (WT) mice showed that tubular secretion accounted for 50-70% of empagliflozin urinary excretion...
February 7, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29412124/sodium-glucoser-cotransporter-2-inhibitors-glucose-lowering-against-other-hypoglycemic-agents
#19
Konstantinos Avranas, Konstantinos Imprialos, Konstantinos Stavropoulos, Georgios Lales, Alexandos Manafis, Anastasia Skalkou, Lars Kihm
BACKGROUND: The treatment of diabetes remains over the decades challenging, even after the introduction of numerous novel drugs of different classes. Most patients with type 2 diabetes necessitate the combination of multiple agents and eventually use of insulin. The newest, and possibly with the most pleiotropic actions after metformin are the sodium-glucose cotransporter 2 inhibitors (SGLT-2i). This class has a unique mechanism inhibiting the glucose reabsorption in the proximal tubule of the kidney...
February 6, 2018: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/29412123/sodium-glucose-cotransporter-2-inhibitors-the-pleiotropic-mechanisms-of-actions
#20
Panteleimon Pantelidis, Andreas Kalliakmanis, Christos Mitas, Michail Sideris, Charalampos Grassos, Andreas Pittaras, Athanasios Manolis
BACKGROUND: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are a new class of oral antidiabetic drugs. So far, there are three agents approved for use in Europe and in the USA, two in Japan and another four agents under testing. OBJECTIVE: The purpose of this study is to describe the mechanism of action and the favorable and adverse effects of SGLT-2 inhibitors. METHOD: A thorough review of literature indexed in PubMed, Scopus and Cochrane databases was conducted...
February 6, 2018: Cardiovascular & Hematological Disorders Drug Targets
keyword
keyword
107291
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"