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sickle cell malaria prophylaxis

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https://www.readbyqxmd.com/read/27852523/anemia-offers-stronger-protection-than-sickle-cell-trait-against-the-erythrocytic-stage-of-falciparum-malaria-and-this-protection-is-reversed-by-iron-supplementation
#1
M M Goheen, R Wegmüller, A Bah, B Darboe, E Danso, M Affara, D Gardner, J C Patel, A M Prentice, C Cerami
BACKGROUND: Iron deficiency causes long-term adverse consequences for children and is the most common nutritional deficiency worldwide. Observational studies suggest that iron deficiency anemia protects against Plasmodiumfalciparum malaria and several intervention trials have indicated that iron supplementation increases malaria risk through unknown mechanism(s). This poses a major challenge for health policy. We investigated how anemia inhibits blood stage malaria infection and how iron supplementation abrogates this protection...
November 9, 2016: EBioMedicine
https://www.readbyqxmd.com/read/27264144/malaria-parasitemia-and-antimalaria-prophylaxis-in-sickle-cell-anemia-patients-in-steady-staten
#2
Omolade Augustina Awodu, Victoria Ade Wagbatsoma, Mathew Ebose Enosolease
Malaria parasitemia was assessed in 37 known sickle cell anemia patients attending the routine hematological clinic of the University of Benin Teaching Hospital, Benin-City, Edo State. Parasitemia was determined using the quantitative buffy coat analysis. The prevalence of malaria parasitemia among the population studied was 86.5%. There was no significant difference in the prevalence of parasitemia among the male and female sicklers (p=0.35). Malaria parasitemia was significantly associated with hematocrit <0...
March 5, 2008: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/26891514/high-prevalence-of-plasmodium-falciparum-pfcrt-k76t-mutation-in-children-with-sickle-cell-disease-at-a-tertiary-hospital-in-north-western-tanzania
#3
Stella Mongella, Nizar Enweji, Naizihijwa Mnong'one, Mercy Minde, Erasmus Kamugisha, Gote Swedberg
The high prevalence of sickle cell disease (SCD) and trait in Sub-Saharan Africa coincides with the distribution of Plasmodiumfalciparum malaria. Due to prolonged heavy use of chloroquine (CQ) as an antimalarial, drug resistance has developed. Many countries including Tanzania abandoned the use of CQ for uncomplicated malaria, except its use as prophylaxis in patients with sickle cell disease. This study investigated the prevalence of malaria in SCD patients and mutations associated with CQ resistance. Children diagnosed with sickle cell disease attending both outpatient clinic and those admitted at Bugando Medical Centre in northwestern Tanzania were screened for malaria using thick blood smear...
October 2014: Tanzania Journal of Health Research
https://www.readbyqxmd.com/read/26868490/complications-of-sickle-cell-anaemia-in-children-in-northwestern-tanzania
#4
Hamza Saidi, Luke R Smart, Erasmus Kamugisha, Emmanuela E Ambrose, Deogratias Soka, Robert N Peck, Julie Makani
OBJECTIVES: Tanzania has the third highest birth rate of sickle cell anaemia (SCA) in Africa, but few studies describe severity of complications or available treatments, especially in Northwest Tanzania around Lake Victoria where the sickle gene is most prevalent. This is a report of the spectrum of clinical disease and range of interventions available at Bugando Medical Centre (Bugando) in Northwest Tanzania in Africa. METHODS: A cross-sectional study was carried out in Bugando between 1 August 2012 and 30 September 2012...
May 2016: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/26808098/sickle-cell-disease
#5
Martin M Meremikwu, Uduak Okomo
INTRODUCTION: Sickle cell disease causes chronic haemolytic anaemia, dactylitis, and painful acute crises. It also increases the risk of stroke, organ damage, bacterial infections, and complications of blood transfusion. In sub-Saharan Africa, up to one third of adults are carriers of the defective sickle cell gene, and 1% to 2% of babies are born with the disease. METHODS AND OUTCOMES: We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of pharmaceutical interventions to prevent sickle cell crisis and other acute complications in people with sickle cell disease? We searched: Medline, Embase, The Cochrane Library, and other important databases up to January 2015 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview)...
January 22, 2016: Clinical Evidence
https://www.readbyqxmd.com/read/25701866/a-randomized-trial-to-compare-the-safety-tolerability-and-effectiveness-of-3-antimalarial-regimens-for-the-prevention-of-malaria-in-nigerian-patients-with-sickle-cell-disease
#6
RANDOMIZED CONTROLLED TRIAL
Rasaq Olaosebikan, Kolade Ernest, Kalifa Bojang, Olugbenga Mokuolu, Andrea M Rehman, Muna Affara, Davis Nwakanma, Jean-René Kiechel, Taofik Ogunkunle, Tope Olagunju, Rukayat Murtala, Peter Omefe, Tosin Lambe, Surajudeen Bello, Olayinka Ibrahim, Benedict Olorunsola, Ayotade Ojuawo, Brian Greenwood, Paul Milligan
BACKGROUND: Malaria prophylaxis is recommended for persons with sickle cell disease (SCD), but the value of this has been questioned. The aim of this study was to find out whether intermittent preventive treatment (IPT) with a fixed-dose combination of mefloquine-artesunate (MQAS) or sulfadoxine-pyrimethamine plus amodiaquine (SPAQ) was more effective than daily proguanil for malaria prevention in subjects with SCD. METHODS: Patients with SCD were randomized to receive daily treatment with proguanil or IPT with either MQAS or SPAQ once every 2 months at routine clinic visits...
August 15, 2015: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/24944408/effects-of-pyrimethamine-versus-proguanil-in-malarial-chemoprophylaxis-in-children-with-sickle-cell-disease-a-randomized-placebo-controlled-open-label-study
#7
Felicia U Eke, Ifeoma Anochie
BACKGROUND: Malarial chemoprophylaxis is essential for patients with homozygous sickle cell disease (SCD) who live in areas where malaria is endemic. Endemic regions include most sub-Saharan African countries and Southeast Asia. OBJECTIVE: This study compared the efficacy and tolerability of pyrimethamine with that of proguanil and placebo in the prevention of malaria and the complications of Plasmodium falciparum infection (hepatomegaly, splenomegaly, bone pain crisis, hemolytic crisis) in children with SCD...
September 2003: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/24114193/current-sickle-cell-disease-management-practices-in-nigeria
#8
N Galadanci, B J Wudil, T M Balogun, G O Ogunrinde, A Akinsulie, F Hasan-Hanga, A S Mohammed, M O Kehinde, J A Olaniyi, I N Diaku-Akinwumi, B J Brown, S Adeleke, O E Nnodu, I Emodi, S Ahmed, A O Osegbue, N Akinola, H I O Opara, S A Adegoke, J Aneke, A D Adekile
BACKGROUND: Although Nigeria has the highest burden of sickle cell disease (SCD) worldwide, there is still variable and poor utilisation of standard-of-care practices for SCD patients in the country. METHODS: This was a questionnaire survey of doctors in some dedicated SCD clinics in Nigeria in order to document the facilities available and common management practices. RESULTS: There were responses from 18 clinics based in 11 institutions...
March 2014: International Health
https://www.readbyqxmd.com/read/23816320/malaria-clinical-features-and-acute-crisis-in-children-suffering-from-sickle-cell-disease-in-resource-limited-settings-a-retrospective-description-of-90-cases
#9
Michel Ntetani Aloni, Bertin Kadima Tshimanga, Pépé Mfutu Ekulu, Jean Lambert Gini Ehungu, René Makwala Ngiyulu
BACKGROUND: The prevalence of sickle cell disease (SCD) is extremely high in the Democratic Republic of Congo (DRC). Despite the high prevalence of this disease in our midst, there has been no report on the clinical features in the sickle cell pediatric population suffering from malaria in our midst. METHODS: A retrospective survey of records from the Department of Paediatrics of the University Hospital of Kinshasa, Kinshasa, Democratic Republic of Congo, was done for the period 1998–2008...
June 2013: Pathogens and Global Health
https://www.readbyqxmd.com/read/23170194/sickle-cell-anaemia-and-malaria
#10
Lucio Luzzatto
Sickle cell anaemia is a major chapter within haemolytic anaemias; at the same time, its epidemiology is a remarkable signature of the past and present world distribution of Plasmodium falciparum malaria. In this brief review, in keeping with the theme of this journal, we focus on the close and complex relationship betweeen this blood disease and this infectious disease. On one hand, heterozygotes for the sickle gene (AS) are relatively protected against the danger of dying of malaria, as now firmly established through a number of clinical field studies from different parts of Africa...
2012: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/22099364/sickle-cell-disease-in-africa-a-neglected-cause-of-early-childhood-mortality
#11
Scott D Grosse, Isaac Odame, Hani K Atrash, Djesika D Amendah, Frédéric B Piel, Thomas N Williams
Sickle cell disease (SCD) is common throughout much of sub-Saharan Africa, affecting up to 3% of births in some parts of the continent. Nevertheless, it remains a low priority for many health ministries. The most common form of SCD is caused by homozygosity for the β-globin S gene mutation (SS disease). It is widely believed that this condition is associated with very high child mortality, but reliable contemporary data are lacking. We have reviewed available African data on mortality associated with SS disease from published and unpublished sources, with an emphasis on two types of studies: cross-sectional population surveys and cohort studies...
December 2011: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/21718552/sickle-cell-disease
#12
REVIEW
Martin M Meremikwu, Uduak Okomo
INTRODUCTION: Sickle cell disease causes chronic haemolytic anaemia, dactylitis, and painful acute crises. It also increases the risk of stroke, organ damage, bacterial infections, and complications of blood transfusion. In sub-Saharan Africa, up to a third of adults are carriers of the defective sickle cell gene, and 1% to 2% of babies are born with the disease. METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the following clinical questions: what are the effects of pharmaceutical and non-pharmaceutical interventions to prevent sickle cell crisis and other acute complications in people with sickle cell disease? What are the effects of pharmaceutical and non-pharmaceutical interventions to treat pain in people with sickle cell crisis? We searched: Medline, Embase, The Cochrane Library, and other important databases up to March 2010 (Clinical Evidence reviews are updated periodically; please check our website for the most up-to-date version of this review)...
2011: Clinical Evidence
https://www.readbyqxmd.com/read/21547107/erythrocytapheresis-do-not-forget-a-useful-therapy
#13
Heidrun Ullrich, Roland Fischer, Regine Grosse, Uwe Kordes, Claudia Schubert, Bettina Altstadt, Georges Andreu
SUMMARY: In patients with pathologically altered erythrocytes, red blood cell exchange is a very efficient therapeutic measure without important side effects. With increasing migration more patients with e.g. severe malaria or sickle cell anemia have to be treated. In minor or bidirectional ABO-mismatched stem cell transplantations after reduced intensity conditioning, hemolysis can be prevented by prophylactic erythrocytapheresis. Other rare indications for red blood cell exchange are advanced erythropoietic protoporphyria and babesiosis...
2008: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/20831548/cytochrome-p450-cyp2c19-genotypes-in-nigerian-sickle-cell-disease-patients-and-normal-controls
#14
COMPARATIVE STUDY
C P Babalola, O Adejumo, D Ung, Z Xu, A Odetunde, T Kotila, A G Falusi, S Nagar
BACKGROUND AND OBJECTIVE: Subjects with different CYP2C19 genotypes may metabolize proguanil, a pro-drug used for malaria prophylaxis differently and the frequency of the different alleles may be different in patients with sickle-cell disease (SCD) and normal controls. The objective of this study was to evaluate CYP2C19 *1, *2 and *3 allele and genotype frequencies in Nigerian normal controls and SCD patients, and to further compare variant CYP2C19 frequencies in Nigerians with other African populations...
August 2010: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/20694469/sickle-cell-disease-and-malaria-evaluation-of-seasonal-intermittent-preventive-treatment-with-sulfadoxine-pyrimethamine-in-senegalese-patients-a-randomized-placebo-controlled-trial
#15
RANDOMIZED CONTROLLED TRIAL
Saliou Diop, Fabienne Soudré, Moussa Seck, Youssou Bamar Guèye, Tandakha Ndiaye Diéye, Awa Oumar Touré Fall, Abibatou Sall, Doudou Thiam, Lamine Diakhaté
Sickle-cell disease (SCD) patients are at high risk of developing malaria which is a major contributor to morbidity and mortality in this disease. In Senegal, malaria transmission is high during rainy season, between July and October, and it was noted that sickle-cell crisis are frequent during this period. Then we carried out a double-blind randomized controlled trial to compare the impact of monthly sulfadoxine-pyrimethamine (SP) during the high-transmission season versus placebo on malaria incidence and morbidity of sickle-cell anemia...
January 2011: Annals of Hematology
https://www.readbyqxmd.com/read/20530796/high-mortality-from-plasmodium-falciparum-malaria-in-children-living-with-sickle-cell-anemia-on-the-coast-of-kenya
#16
Charlotte F McAuley, Clare Webb, Julie Makani, Alexander Macharia, Sophie Uyoga, Daniel H Opi, Carolyne Ndila, Antony Ngatia, John Anthony G Scott, Kevin Marsh, Thomas N Williams
Although malaria is widely considered a major cause of death in young children born with sickle cell anemia (SCA) in sub-Saharan Africa, this is poorly quantified. We attempted to investigate this question through 4 large case-control analyses involving 7164 children living on the coast of Kenya. SCA was associated with an increased risk of admission to hospital both with nonmalaria diseases in general (odds ratio [OR] = 4.17; 95% confidence interval [CI], 1.95-8.92; P < .001) and with invasive bacterial diseases in particular (OR = 8...
September 9, 2010: Blood
https://www.readbyqxmd.com/read/19852829/presumptive-treatment-with-sulphadoxine-pyrimethamine-versus-weekly-chloroquine-for-malaria-prophylaxis-in-children-with-sickle-cell-anaemia-in-uganda-a-randomized-controlled-trial
#17
RANDOMIZED CONTROLLED TRIAL
Victoria Nakibuuka, Grace Ndeezi, Deborah Nakiboneka, Christopher M Ndugwa, James K Tumwine
BACKGROUND: Malaria carries high case fatality among children with sickle cell anaemia. In Uganda, chloroquine is used for prophylaxis in these children despite unacceptably high levels of resistance. Intermittent presumptive treatment with sulphadoxine-pyrimethamine (SP) has shown great potential for reducing prevalence of malaria and anaemia among pregnant women and infants. OBJECTIVE: To compare the efficacy of monthly SP presumptive treatment, versus weekly chloroquine for malaria prophylaxis in children attending the Sickle Cell Clinic, Mulago Hospital...
2009: Malaria Journal
https://www.readbyqxmd.com/read/19837619/analysis-of-malaria-associated-genetic-traits-in-cabo-verde-a-melting-pot-of-european-and-sub-saharan-settlers
#18
COMPARATIVE STUDY
Joana Alves, Patrícia Machado, João Silva, Nilza Gonçalves, Letícia Ribeiro, Paula Faustino, Virgílio Estólio do Rosário, Licínio Manco, Leonor Gusmão, António Amorim, Ana Paula Arez
Malaria has occurred in the Cabo Verde archipelago with epidemic characteristics since its colonization. Nowadays, it occurs in Santiago Island alone and though prophylaxis is not recommended by the World Health Organization, studies have highlight the prospect of malaria becoming a serious public health problem as a result of the presence of antimalarial drug resistance associated with mutations in the parasite populations and underscore the need for tighter surveillance. Despite the presumptive weak immune status of the population, severe symptoms of malaria are not observed and many people present a subclinical course of the disease...
January 15, 2010: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/19674265/sickle-cell-children-traveling-abroad-primary-risk-is-infection
#19
Camille Runel-Belliard, Emmanuelle Lesprit, Béatrice Quinet, Emmanuel Grimprel
BACKGROUND: Pediatricians taking care of sickle cell children in France are concerned about giving travel advice. Very few articles are published and no study has been done about it. A lot of pediatricians are using their own experience to decide if sickle cell children can travel abroad. Studying the consequences of such travel for sickle cell children is important to discuss common recommendations. METHODS: We conducted a prospective study from June 2006 to December 2007 on desires to travel expressed during our consultations with sickle cell children...
July 2009: Journal of Travel Medicine
https://www.readbyqxmd.com/read/19514855/malaria-as-a-cause-of-morbidity-and-mortality-in-children-with-homozygous-sickle-cell-disease-on-the-coast-of-kenya
#20
Albert N Komba, Julie Makani, Manish Sadarangani, Tolu Ajala-Agbo, James A Berkley, Charles R J C Newton, Kevin Marsh, Thomas N Williams
BACKGROUND: To date, it has been widely assumed that malaria is a common cause of morbidity and mortality in children with sickle cell disease (SCD) in malaria-endemic countries, and as a result, malarial prophylaxis is commonly recommended. Nevertheless, few data are available that support this practice. METHODS: We conducted a retrospective analysis of the data collected prospectively from children aged 0-13 years who were admitted to Kilifi District Hospital during the period from July 1998 through June 2005...
July 15, 2009: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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