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Henoch Shönlein nephritis

Maxime D Bérubé, Normand Blais, Sylvain Lanthier
Henoch-Shönlein purpura (HSP) is a systemic small vessel vasculitis. Most patients present during childhood. The characteristic association of purpura, arthralgia, abdominal pain, and nephritis reflects the predominant distribution of vasculitis. Headaches and mild behavioral changes suggest CNS involvement in one-third of HSP patients. Salient central nervous system (CNS) manifestations are rarer and mostly reported in adults and patients with a severe disease course. Diagnosis of CNS vasculitis is rarely confirmed by histopathology and generally relies on "suggestive" imaging showing brain hemorrhages, infarcts and edema, predominantly located in the parieto-occipital regions...
2014: Handbook of Clinical Neurology
Th Eleftheriadis, V Liakopoulos, M Boulbou, F Karasavvidou, E Atmatzidis, S Dovas, G Antoniadi, I Stefanidis
Henoch-Schönlein purpura (HSP) is a small vessel vasculitis characterized by purpuric skin rash, haematuria, abdominal pain, gastrointestinal bleeding and arthritis. Nephritis is more frequent and severe in adults than in children, with relatively more adults developing renal insufficiency. Another, fortunately rare, manifestation of HSP that increases mortality significantly, is diffuse alveolar haemorrhage. We report a rare case of an adult male patient with full-blown HSP that followed a respiratory tract infection...
October 2006: Hippokratia
Evangeline Pillebout, Dominique Nochy, Eric Thervet
Henoch-Shönlein purpura (HSP) is an immunoglobulin A (IgA) vasculitis that affects the small vessels. It is a multi-organ system disease that may include cutaneous purpura, arthralgia, acute enteritis and nephritis. Nephritis is characterized by mesangial proliferation with IgA deposits. Neurological, pulmonary, cardiac or genitourinary complications occur rarely. The acute stage progresses by successive flare-ups of limited duration. Although the cause is unknown, it is clear that IgA plays a central role in the immunopathogenesis of HSP...
December 2009: Néphrologie & Thérapeutique
Yoshikuni Nagayama, Shigeki Iwasaki, Hiroyuki Yamaguchi, Ashio Yoshimura
A 29-year-old man was admitted to our hospital because of high fever and dyspnea. About two months before this admission the patient was diagnosed as Henoch-Schönlein purpura nephritis who was treated with 40 mg/day of prednisolone(PSL). When the dose of PSL was decreased to 32.5 mag/day, his temperature was 40 degrees C, the pulse was 120 beats per minute and the blood pressure was 71/36 mmHg. In the peripheral blood study, the white blood cell count was 23,800/microL and C-reactive protein was 6.1 mg/dL...
2007: Nihon Jinzo Gakkai Shi
Motomu Hashimoto, Fumiaki Nogaki, Emi Oida, Misa Tanaka, Toshiko Ito-Ihara, Keiko Nomura, Ning Liu, Eri Muso, Atsushi Fukatsu, Toru Kita, Takahiko Ono
A 28-year-old Japanese woman developed fever, leg edema, purpura, and abdominal pain during the puerperal period, showing nephrotic syndrome with microscopic hematuria. At first she was thought to have Henoch-Shönlein purpura nephritis and was given steroids at another hospital. Because anasarca and massive urinary protein excretion developed, she was referred to our hospital. Renal biopsy specimens showed endocapillary proliferative glomerulonephritis with massive IgA and C3d deposition along the capillary loops and in the mesangium...
March 2007: Clinical and Experimental Nephrology
Marco Zaffanello, Milena Brugnara, Massimo Franchini
Although severe kidney involvement in children with Henoch-Shonlein purpura (HSP) is rarer than that in adults, morbidity should not be underevaluated and follow-up is mandatory. Some drugs are introduced as well-defined treatment options, others can be promising therapeutic alternatives. Therapy of HSP nephritis in children can range from simply steroids to combined immunosuppressant treatments. The prophylactic treatment for renal complication of patients with HSP has been sometimes suggested, but with conflicting results and ultimately not clearly proven...
January 10, 2007: TheScientificWorldJournal
F J de la Prada Alvarez, A M Prados Gallardo, A Tugores Vázquez, M Uriol Rivera, C Saus Sarrias, A Morey Molina
Schönlein-Henoch purpura is a systemic vasculitic disorder involving both arterioles and capillaries. Although it is mainly a disease of early chilhood, it can occur at any age. The disease may be more severe in the few adults who develop this disorder. The clinical manifestations include a classic tetrad: rash, arthralgias, abdominal pain and renal disease. However it may affect almost every other bodily organ such us myocardium, lungs, ureter and nervous system. Pulmonary hemorrhage, a rare complication of Schönlein-Henoch purpura, has been found mainly in adolescents and adults, and it is associated with significant mortality...
September 2005: Anales de Medicina Interna: Organo Oficial de la Sociedad Española de Medicina Interna
F Watanabe, T Yoshida, T Mitsumori, T Konishi, M Akizuki, K Kameyama, Y Hosoda
No abstract text is available yet for this article.
August 10, 1994: Nihon Naika Gakkai Zasshi. the Journal of the Japanese Society of Internal Medicine
N Yoshikawa, S Yoshiara, K Yoshiya, T Matsuo, S Okada
An electron-microscopic study of the glomerular basement membrane was made on 242 renal biopsies from 222 children with a variety of renal diseases. Lysis of the basement membrane was observed in 16 of the 25 children with Henoch-Schönlein nephritis, 36 of the 72 with IgA nephropathy and one with acute poststreptococcal glomerulonephritis. Lysis was frequently associated with subepithelial dense deposits and polymorphonuclear leukocytes, and these are thought to play a role in the lytic process. There was a significant correlation between the presence of lysis of the basement membrane, the degree of proteinuria and the severity of glomerular changes by light microscopy...
October 1986: Journal of Pathology
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