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https://www.readbyqxmd.com/read/28886863/critical-role-of-mammalian-target-of-rapamycin-for-il-10-dendritic-cell-induction-by-a-flagellin-a%C3%A2-conjugate-in-preventing-allergic-sensitization
#1
Stefan Schülke, Anna-Helena Fiedler, Ann-Christine Junker, Adam Flaczyk, Sonja Wolfheimer, Andrea Wangorsch, Anke Heinz, Hendrik Beckert, Birgit Nagl, Barbara Bohle, Stefan Vieths, Masako Toda, Stephan Scheurer
BACKGROUND: Fusion proteins incorporating the Toll-like receptor 5 ligand flagellin are currently undergoing clinical trials as vaccine candidates for many diseases. OBJECTIVE: We studied the mechanisms of immune modulation by a flagellin:allergen fusion protein containing the Toll-like receptor 5 ligand flagellin A from Listeria monocytogenes and the birch pollen allergen Bet v 1 (recombinant flagellin A [rFlaA]:Betv1). METHODS: BALB/c mice were vaccinated with rFlaA:Betv1 in an experimental Bet v 1 sensitization model...
August 25, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28875499/the-intestinal-microbiota-determines-the-colitis-inducing-potential-of-t-bet-deficient-th-cells-in-mice
#2
Jakob Zimmermann, Pawel Durek, Anja A Kühl, Florian Schattenberg, Patrick Maschmeyer, Francesco Siracusa, Katrin Lehmann, Kerstin Westendorf, Melanie Weber, René Riedel, Susann Müller, Andreas Radbruch, Hyun-Dong Chang
Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of naïve T cells into Rag(-/-) mice requires expression of the transcription factor T-bet by the T cells. Here, we formally show that the intestinal microbiota composition of the Rag(-/-) recipient determines whether or not T-bet-deficient Th cells can induce colitis and we have resolved the differences of the two microbiomes, permissive or non-permissive to T-bet-independent colitis. Our data highlight the dominance of the microbiota over particular T cell differentiation programs in the pathogenesis of chronic intestinal inflammation...
September 6, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28863383/acetylenic-derivative-of-betulin-induces-apoptosis-in-endometrial-adenocarcinoma-cell-line
#3
Lukasz Szoka, Ewa Karna, Kornelia Hlebowicz-Sarat, Jacek Karaszewski, Stanisław Boryczka, Jerzy A Palka
Since betulin (Bet) and its acetylenic derivative, 28-O-propynoylbetulin (proBet) were shown to induce apoptosis in several cancer cell lines, we studied the mechanism of this process in human endometrial adenocarcinoma cells (EA). Previous studies suggested that this group of compounds affect prolidase activity (proline releasing enzyme from imidodipeptides) and collagen biosynthesis (proline utilizing process) providing substrate (proline) for proline oxidase (POX) dependent apoptosis. Here we provide evidence that Bet and proBet exhibit prolidase-inducing activity in EA cell line...
August 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28840412/gambling-participation-expenditure-and-risk-of-harm-in-australia-1997-1998-and-2010-2011
#4
Andrew Richard Armstrong, Anna Thomas, Max Abbott
Gambling-related harm results primarily from financial losses. Internationally Australia continues to rank as the largest spending nation per capita on gambling products. This would suggest that Australian gamblers are at disproportionately high risk of harm despite almost two decades of industry scrutiny and regulation, and investment in research, treatment and education programs. However, declines in participation rates, per capita expenditure, household expenditure, national disposable income spent on gambling and problem gambling rates have been cited as evidence that fewer people are gambling, that gamblers are spending less, and that gambling safety in Australia has improved...
August 24, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28827294/bet-2-can-procalcitonin-accurately-diagnose-serious-bacterial-infection-in-emergency-department-patients-with-sirs
#5
Joel Wilson, Jerry Baskerville, Sahar Zarabi
A shortcut review was carried out to establish whether serum procalcitonin levels can be used to identify serious bacterial infection in ED patients with undifferentiated SIRS. 14 papers presented the best evidence to answer the clinical question. The review concludes that raised procalcitonin levels are associated with bacteraemia; however, there are no clinical management studies addressing this question in ED patients with SIRS.
September 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28827293/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#6
Kerstin de Wit
No abstract text is available yet for this article.
September 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28827292/bet-1-sirs-criteria-as-a-way-of-predicting-mortality-in-acute-pancreatitis
#7
Joel Wilson, Sahar Zarabi
A shortcut review was carried out to establish whether the presence of systemic inflammatory response criteria in emergency department patients with pancreatitis is predictive of the risk of death. Eight papers presented the best evidence to answer the clinical question. The review concludes that the presence of SIRS in emergency department patients with pancreatitis is associated with a higher risk of mortality.
September 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28811967/il-18-receptor-marks-functional-cd8-t-cells-in-non-small-cell-lung-cancer
#8
Eleonora Timperi, Chiara Focaccetti, Daniela Gallerano, Mariangela Panetta, Sheila Spada, Enzo Gallo, Paolo Visca, Federico Venuta, Daniele Diso, Arsela Prelaj, Flavia Longo, Francesco Facciolo, Paola Nisticò, Vincenzo Barnaba
IL-18 is an inflammasome-related cytokine, member of the IL-1 family, produced by a wide range of cells in response to signals by several pathogen- or damage-associated molecular patterns. It can be highly represented in tumor patients, but its relevance in human cancer development is not clear. In this study, we provide evidence that IL-18 is principally expressed in tumor cells and, in concert with other conventional Th1 cell-driven cytokines, has a pivotal role in establishing a pro-inflammatory milieu in the tumor microenvironment of human non-small cell lung cancer (NSCLC)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28766336/kish-graphite-flakes-as-a-cathode-material-for-an-aluminum-chloride-graphite-battery
#9
Shutao Wang, Kostiantyn V Kravchyk, Frank Krumeich, Maksym V Kovalenko
Nonaqueous, ionic liquid-based aluminum chloride-graphite batteries (AlCl3-GBs) are a highly promising post-Li-ion technology for low-cost and large-scale storage of electricity because these batteries feature exclusively highly abundant chemical elements and simple fabrication methods. In this work, we demonstrate that synthetic kish graphite, which is a byproduct of steelmaking, can be used as a cathode in AlCl3-GB and exhibits high capacities of ≤142 mAh g(-1). The comprehensive characterization of kish graphite flakes and other forms of graphite by X-ray diffraction, Raman spectroscopy, and Brunauer-Emmett-Teller surface area analysis provides solid evidence that the exceptional electrochemical behavior of kish graphite flakes is mainly determined by the high structural order of carbon atoms, a low level of defects, and a unique "crater morphology"...
August 30, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28756897/role-of-cd11c-t-bet-b-cells-in-human-health-and-disease
#10
REVIEW
Jodi L Karnell, Varsha Kumar, Jingya Wang, Shu Wang, Elisaveta Voynova, Rachel Ettinger
A growing body of evidence suggests that when B cells are chronically stimulated, a phenotypically unique subset expands. Data suggest that this atypical population contains B cell receptor (BCR) specificities capable of binding the antigen, or sets of antigens that initiated the expansion of these cells. These B cells have been given various names, including double negative B cells, atypical memory B cells, tissue-like memory B cells, or age associated B cells (ABCs). However, on close inspection these reports described B cell subsets that closely resemble B cells we refer to as CD11c(+) B cells that often express T-bet...
July 11, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28743300/public-attitudes-towards-gambling-product-harm-and-harm-reduction-strategies-an-online-study-of-16-88%C3%A2-year-olds-in-victoria-australia
#11
Samantha L Thomas, Melanie Randle, Amy Bestman, Hannah Pitt, Steven J Bowe, Sean Cowlishaw, Mike Daube
BACKGROUND: Gambling has quickly emerged as an important global public health issue. With new technologies used to develop high intensity gambling products and promotions aimed at driving consumption, public health organisations and researchers, community groups, and politicians have argued for a range of regulatory and education measures aimed at reducing gambling harm. However, there has been limited research seeking to understand community perceptions of the harms associated with gambling products and environments, and the level of community support for strategies designed to prevent and reduce gambling harm...
July 25, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28735813/atypical-memory-b-cells-in-human-chronic-infectious-diseases-an-interim-report
#12
Silvia Portugal, Nyamekye Obeng-Adjei, Susan Moir, Peter D Crompton, Susan K Pierce
Immunological memory is a remarkable phenomenon in which survival of an initial infection by a pathogen leads to life-long protection from disease upon subsequent exposure to that same pathogen. For many infectious diseases, long-lived protective humoral immunity is induced after only a single infection in a process that depends on the generation of memory B cells (MBCs) and long-lived plasma cells. However, over the past decade it has become increasingly evident that many chronic human infectious diseases to which immunity is not readily established, including HIV-AIDS, malaria and TB, are associated with fundamental alterations in the composition and functionality of MBC compartments...
July 11, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28734727/treatment-of-pharyngotympanic-tube-dysfunction
#13
REVIEW
Holger H Sudhoff, Stefan Mueller
Eustachian tube dysfuntion intends to describe a variety of signs, symptoms, and physical findings that result from the impairment of ET function. A large variety of methods have been employed to assess ET function in the literature. Due to the lack of high level evidence, it is difficult to draw conclusions on the effectiveness of medical and surgical treatments. There are various medical and surgical interventions available for chronic obstructive ET dysfunction including balloon Eustachian tuboplasty (BET) and laser or microdebrider tuboplasty...
July 19, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28729226/solanum-paniculatum-l-decreases-levels-of-inflammatory-cytokines-by-reducing-nfkb-tbet-and-gata3-gene-expression-in-vitro
#14
Raimon Rios, Hugo Bernardino Ferreira da Silva, Norma Vilany Queiroz Carneiro, Anaque de Oliveira Pires, Tamires Cana Brasil Carneiro, Ryan Dos Santos Costa, Cintia Rodrigues Marques, Marta Santos Serafim Machado, Eudes da Silva Velozo, Telma M G da Silva, Tania M S da Silva, Adilva de Souza Conceição, Neuza Maria Alcântara-Neves, Camila Alexandrina Figueiredo
ETHNOPHARMACOLOGICAL RELEVANCE: Solanum paniculatum L., popularly known as jurubeba, is a common subtropical plant from Brazil, Paraguay, Bolivia and Argentina, that is used in folk medicine for the treatment of anemia, gastrointestinal disorders and inflammatory conditions in general. In addition to that, an ethnobotanical survey in "Todos os Santos" Bay have pointed out S. paniculatum as an herb to treat asthma. Previous publications have shown that S. paniculatum possesses antibiotic, antioxidant and modulatory effects on gastric acid secretion; however, its anti-inflammatory potential remains unexplored...
July 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28728039/cognitive-restructuring-of-gambling-related-thoughts-a-systematic-review
#15
REVIEW
Maxime Chrétien, Isabelle Giroux, Annie Goulet, Christian Jacques, Stéphane Bouchard
Gamblers' thoughts have a fundamental influence on their gambling problem. Cognitive restructuring is the intervention of choice to correct those thoughts. However, certain difficulties are noted in the application of cognitive restructuring techniques and the comprehension of their guidelines. Furthermore, the increase of skill game players (e.g. poker) entering treatment creates a challenge for therapists, as these gamblers present with different thoughts than those of the gamblers usually encountered in treatment (e...
December 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28724568/bet-2-poor-evidence-on-whether-teaching-cognitive-debiasing-or-cognitive-forcing-strategies-lead-to-a-reduction-in-errors-attributable-to-cognition-in-emergency-medicine-students-or-doctors
#16
Govind Oliver, Gopal Oliver, Rick Body
A short review was carried out to see if teaching cognitive forcing strategies reduces cognitive error in the practice of emergency medicine. Two relevant papers were found using the described search strategy. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. There is currently little evidence that teaching cognitive forcing strategies reduces cognitive error in the practice of emergency medicine.
August 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28724567/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#17
Janos Baombe
No abstract text is available yet for this article.
August 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28724566/bet-1-lidocaine-with-propofol-to-reduce-pain-on-injection
#18
Janos P Baombe, Laura Howard
A short review was carried out to see if mixing lidocaine with propofol is a safe and effective method in reducing the commonly reported pain at the injection site. Four relevant papers were found using the described search strategy. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. Although a promising idea, a paucity of good quality evidence suggests further needed research.
August 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28647808/characterization-of-arabidopsis-thaliana-regrowth-patterns-suggests-a-trade-off-between-undamaged-fitness-and-damage-tolerance
#19
Daniel R Scholes, Erika N Rasnick, Ken N Paige
Herbivory is a fundamental type of plant-animal interaction that presents substantial selection pressure on plants to replace lost tissues and to prevent subsequent losses in fitness. Apical herbivory, which entails removal or damage to the apical meristem, causes a change in plant architecture by disrupting the balance of hormones produced in part by the apical meristem. Therefore, for an annual semelparous plant, the ability to preserve reproductive success following damage (i.e., to tolerate damage) is largely dependent on the plant's pre-damage investment into fitness and its regrowth pattern following damage...
July 2017: Oecologia
https://www.readbyqxmd.com/read/28639827/the-effects-of-alcohol-expectancy-and-intake-on-slot-machine-gambling-behavior
#20
Dominic Sagoe, Rune Aune Mentzoni, Tony Leino, Helge Molde, Sondre Haga, Mikjel Fredericson Gjernes, Daniel Hanss, Ståle Pallesen
Background and aims Although alcohol intake and gambling often co-occur in related venues, there is conflicting evidence regarding the effects of alcohol expectancy and intake on gambling behavior. We therefore conducted an experimental investigation of the effects of alcohol expectancy and intake on slot machine gambling behavior. Methods Participants were 184 (females = 94) individuals [age range: 18-40 (mean = 21.9) years] randomized to four independent conditions differing in information/expectancy about beverage (told they received either alcohol or placebo) and beverage intake [actually ingesting low (target blood alcohol concentration [BAC] < 0...
June 1, 2017: Journal of Behavioral Addictions
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