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https://www.readbyqxmd.com/read/28493742/effects-of-alcohol-initial-gambling-outcomes-impulsivity-and-gambling-cognitions-on-gambling-behavior-using-a-video-poker-task
#1
William R Corbin, Jessica M Cronce
Drinking and gambling frequently co-occur, and concurrent gambling and drinking may lead to greater negative consequences than either behavior alone. Building on prior research on the effects of alcohol, initial gambling outcomes, impulsivity, and gambling cognitions on gambling behaviors using a chance-based (nonstrategic) slot-machine task, the current study explored the impact of these factors on a skill-based (strategic) video poker task. We anticipated larger average bets and greater gambling persistence under alcohol relative to placebo, and expected alcohol effects to be moderated by initial gambling outcomes, impulsivity, and gambling cognitions...
June 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28493312/minor-allergen-patterns-in-birch-pollen-allergen-products-a-question-of-pollen
#2
J Zimmer, S Döring, D Strecker, J H Trösemeier, K M Hanschmann, F Führer, S Vieths, S Kaul
BACKGROUND: Contrary to the scientific differentiation between major and minor allergens, the regulatory framework controlling allergen products in the EU distinguishes relevant and non-relevant allergens. Given the lack of knowledge on their clinical relevance, minor allergens are usually not controlled by allergen product specifications. Especially in birch pollen (BP) allergen products, minor allergens are commonly disregarded. OBJECTIVES: To quantify three minor allergens in BP allergen products from different manufacturers and to assess the influence of the utilized BP on minor allergen patterns...
May 10, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28480017/the-evolution-of-different-maternal-investment-strategies-in-two-closely-related-desert-vertebrates
#3
Joshua R Ennen, Jeffrey E Lovich, Roy C Averill-Murray, Charles B Yackulic, Mickey Agha, Caleb Loughran, Laura Tennant, Barry Sinervo
We compared egg size phenotypes and tested several predictions from the optimal egg size (OES) and bet-hedging theories in two North American desert-dwelling sister tortoise taxa, Gopherus agassizii and G. morafkai, that inhabit different climate spaces: relatively unpredictable and more predictable climate spaces, respectively. Observed patterns in both species differed from the predictions of OES in several ways. Mean egg size increased with maternal body size in both species. Mean egg size was inversely related to clutch order in G...
May 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28465523/the-mechanism-of-iron-binding-processes-in-erionite-fibres
#4
Alessandro Pacella, Carlo Cremisini, Elisa Nardi, Maria Rita Montereali, Ida Pettiti, Paolo Ballirano
Fibrous erionite-Na from Rome (Oregon, USA) was K-exchanged and characterized from the structural point of view. In addition, the modifications experienced after contact with a Fe(II) source were investigated for evaluating if the large potassium ions, blocking off nearly all the erionite cavity openings, might prevent the Fe(II) binding process, which is currently assumed to be one of the reasons of the toxicity of erionite. The K-exchanged sample had a 95% reduction of the BET surface area indicating that it behaves as a mesoporous material...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28428437/bet-2-striking-the-right-balance-anticoagulation-and-isolated-distal-deep-vein-thrombosis
#5
Tom Jones, Dan Horner
A short-cut review was carried out to establish whether treatment of isolated distal deep vein thrombosis with therapeutic anticoagulation can reduce adverse clinical outcomes. A meta-analysis from 2011 and 11 subsequent directly relevant papers were found using the reported search strategy. Of these, 7 in total presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated...
May 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28428435/bet-1-a-glass-half-full-thrombolysis-for-the-treatment-of-submassive-pulmonary-embolism
#6
Liam Barrett, Dan Horner
A short-cut review was carried out to establish whether thrombolysis in addition to therapeutic anticoagulation could be of benefit in submassive (intermediate risk) pulmonary embolism (PE). 64 directly relevant papers were found using the reported search strategy. Of these, three presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated. It is concluded that there is insufficient evidence to support the routine use of adjuvant thrombolytic therapy at any dose for patients with submassive PE...
May 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28426517/effects-of-betaine-supplementation-on-muscle-strength-and-power-a-systematic-review
#7
Ahmed Ismaeel
Betaine has recently gotten much attention for its potential role as an ergogenic aid and has become a common ingredient in peri-workout dietary supplements. The purpose of this systematic review of the literature was to investigate the effects of betaine supplementation on muscular strength and power. A computerized literature search of 3 databases (PubMed, MEDLINE, and Scopus) was performed. Included in the review were randomized controlled trials that measured muscle strength, power, and/or endurance in healthy participants...
April 15, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28405920/effector-functions-of-memory-ctls-can-be-affected-by-signals-received-during-reactivation
#8
Yingjun Lv, Elliot Mattson, Anjuli Bhadurihauck, Karla Garcia, Lei Li, Zhengguo Xiao
Memory cytotoxic T lymphocytes (CTLs) are able to provide protections to the host against repeated insults from intracellular pathogens. However, it has not been completely understood how the effector functions of memory CTLs are induced upon antigen challenge, which is directly related to the efficacy of their protection. Third signal cytokines, such as IL-12 and type I interferon, have been suggested to be involved in the protective function of memory CTLs, but direct evidence is warranted. In this report, we found that memory CTLs need to be reactivated to exert effector functions...
April 12, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28367454/effects-of-vitamin-b6-deficiency-on-the-composition-and-functional-potential-of-t-cell-populations
#9
Bingjun Qian, Shanqi Shen, Jianhua Zhang, Pu Jing
The immune system is critical in preventing infection and cancer, and malnutrition can weaken different aspects of the immune system to undermine immunity. Previous studies suggested that vitamin B6 deficiency could decrease serum antibody production with concomitant increase in IL4 expression. However, evidence on whether vitamin B6 deficiency would impair immune cell differentiation, cytokines secretion, and signal molecule expression involved in JAK/STAT signaling pathway to regulate immune response remains largely unknown...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28358293/older-and-younger-adults-strategic-control-of-metacognitive-monitoring-the-role-of-consequences-task-experience-and-prior-knowledge
#10
Shannon McGillivray, Alan D Castel
Background/Study Context: Although explicit memory abilities decline during older adulthood, there is evidence that suggests that metacognitive capabilities are relatively well preserved. However, it is unclear what effect aging, consequences of forgetting, prior knowledge, and task experience have on the strategic control and use of one's metacognitive capabilities. METHODS: In the current study, older and younger adults were presented with six unique lists of words (Experiment 1), related and unrelated word pairs (Experiment 2), or items within specific scenarios (e...
May 2017: Experimental Aging Research
https://www.readbyqxmd.com/read/28342010/aridity-promotes-bet-hedging-via-delayed-hatching-a-case-study-with-two-temporary-pond-crustaceans-along-a-latitudinal-gradient
#11
Tom Pinceel, Bram Vanschoenwinkel, Wouter Hawinkel, Karen Tuytens, Luc Brendonck
Climate change does affect not only average rainfall and temperature but also their variation, which can reduce the predictability of suitable conditions for growth and reproduction. This situation is problematic for inhabitants of temporary waters whose reproductive success depends on rainfall and evaporation that determine the length of the aquatic phase. For organisms with long-lived dormant life stages, bet hedging models suggest that a fraction of these should stay dormant during each growing season to buffer against the probability of total reproductive failure in variable environments...
May 2017: Oecologia
https://www.readbyqxmd.com/read/28341795/bet-2-laser-therapy-in-the-treatment-of-acute-hamstring-muscle-injuries
#12
Tom Hughes, Michael Callaghan
Local laser therapy has been suggested as a promising treatment for acute hamstring muscle tears. We carried out a shortcut systematic review to establish whether therapeutic lasers are beneficial for patients with acute hamstring tears. Despite a comprehensive literature search, no studies that were directly relevant to the question could be identified. The clinical bottom line is therefore that there is currently no evidence for the use of any form of laser therapy in the treatment of acute hamstring muscle tears...
April 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28319932/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#13
Bernard A Foëx
No abstract text is available yet for this article.
November 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28319931/bet-1-tranexamic-acid-in-epistaxis-who-bloody-nose
#14
Nicola Penrose, Gabby May
A shortcut review was carried out to establish whether tranexamic acid is effective in controlling epistaxis. Three studies were directly relevant to the question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these studies are tabulated. The clinical bottom line is that there is not enough evidence to recommend tranexamic acid in the standard management of epistaxis.
November 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28248992/altered-regulation-and-expression-of-genes-by-bet-family-of-proteins-in-copd-patients
#15
Rajneesh Malhotra, Nisha Kurian, Xiao-Hong Zhou, Fanyi Jiang, Susan Monkley, Amy DeMicco, Ib G Clausen, Göran Delgren, Goran Edenro, Miika J Ahdesmäki, Maryam Clausen, Lisa Öberg, Elisabeth Israelsson, Graham Belfield, Outi Vaarala
BACKGROUND: BET proteins (BRD2, BRD3, BRDT and BRD4) belong to the family of bromodomain containing proteins, which form a class of transcriptional co-regulators. BET proteins bind to acetylated lysine residues in the histones of nucleosomal chromatin and function either as co-activators or co-repressors of gene expression. An imbalance between HAT and HDAC activities resulting in hyperacetylation of histones has been identified in COPD. We hypothesized that pan-BET inhibitor (JQ1) treatment of BET protein interactions with hyperacetylated sites in the chromatin will regulate excessive activation of pro-inflammatory genes in key inflammatory drivers of alveolar macrophages (AM) in COPD...
2017: PloS One
https://www.readbyqxmd.com/read/28168840/mother-s-age-and-hatching-phenology-strategy-of-heterocypris-incongruens-crustacea-ostracoda-in-unpredictable-environment
#16
Valeria Rossi, Andrea Gandolfi, Paolo Menozzi
We report experimental evidence of egg polyphenism in clonal lineages of Heterocypris incongruens from an ephemeral pond on a Mediterranean Island (Lampedusa, Italy). In controlled laboratory conditions, clonal females produced three different kinds of eggs: (i) resting and desiccation-resistant eggs, (ii) nonresting eggs that hatched gradually within 2 month hydroperiod, and (iii) nonresting delayed development eggs that hatched synchronously. Clonal females showed a diversified bet-hedging strategy to spread risk of reproduction in ponds with unpredictable hydroperiod...
February 7, 2017: Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology
https://www.readbyqxmd.com/read/28152187/clinal-population-divergence-in-an-adaptive-parental-environmental-effect-that-adjusts-seed-banking
#17
Christian Lampei, Johannes Metz, Katja Tielbörger
Bet-hedging via between-year seed dormancy is a costly strategy for plants in unpredictable environments. Theoretically, fitness costs can be reduced through a parental environmental effect when the environment is partly predictable. We tested whether populations from environments that differ in predictability diverged in parental effects on seed dormancy. Common garden-produced seeds of the two annual plant species Biscutella didyma and Bromus fasciculatus collected along an aridity gradient were grown under 12 irrigation treatments...
February 2, 2017: New Phytologist
https://www.readbyqxmd.com/read/28145999/short-term-effects-of-methylphenidate-on-math-productivity-in-children-with-attention-deficit-hyperactivity-disorder-are-mediated-by-symptom-improvements-evidence-from-a-placebo-controlled-trial
#18
Anne Fleur Kortekaas-Rijlaarsdam, Marjolein Luman, Edmund Sonuga-Barke, Pierre M Bet, Jaap Oosterlaan
BACKGROUND: Although numerous studies report positive effects of methylphenidate on academic performance, the mechanism behind these improvements remains unclear. This study investigates the effects of methylphenidate on academic performance in children with attention-deficit/hyperactivity disorder (ADHD) and the mediating and moderating influence of ADHD severity, academic performance, and ADHD symptom improvement. METHODS: Sixty-three children with ADHD participated in a double-blind placebo-controlled crossover study comparing the effects of long-acting methylphenidate and placebo...
April 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28109308/semaphorin-7a-as-a-potential-immune-regulator-and-promising-therapeutic-target-in-rheumatoid-arthritis
#19
Jianmin Xie, Hao Wang
BACKGROUND: Semaphorin 7A (Sema7A) is expressed by several different classes of lymphoid and myeloid cells and is a potent immunomodulator. We examined the role of Sema7A in modulating cellular immune responses and to provide experimental data validating the therapeutic potential of Sema7A in rheumatoid arthritis (RA). METHODS: Soluble Sema7A (sSema7A) levels in the serum and synovial fluid from patients with RA or osteoarthritis, as well as cytokine secretions, were analyzed with an enzyme-linked immunosorbent assay...
January 21, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27974431/bet-2-ice-water-immersion-other-vagal-manoeuvres-or-adenosine-for-svt-in-children
#20
REVIEW
Marion Campbell, Silvia Ruiz Buitrago
A short cut review was carried out to establish whether a vagal manoeuvre was better than or as good as adenosine at safely terminating supraventricular tachycardia in children. Forty unique papers were found in Medline and Embase using the reported searches, of which five were relevant. A hand search of the forty unique citations identified a further nine relevant papers. Thus, 14 papers presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated...
January 2017: Emergency Medicine Journal: EMJ
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