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Wu-Jun Liu, Ke Tian, Li-Li Ling, Han-Qing Yu, Hong Jiang
The optimal strategy for the safe disposal of large amounts of hydrophyte biomass with enriched levels of N and P is challenging. In this study, we proposed and illustrated a facile pyrolysis approach to prepare an N, P-dually doped porous carbon (NPC) material with robust energy storage performance using a thermochemical self-doping process and a widely distributed hydrophyte biomass (Typha angustifolia). As a supercapacitor electrode material for electrochemical energy storage, the NPC shows a maximum capacitance of 257 F g-1 and energy density of 19...
October 18, 2016: Environmental Science & Technology
Pei Y Liu, Bernard Atmadibrata, Sujanna Mondal, Andrew E Tee, Tao Liu
Neuroblastoma is the most common solid tumor in early childhood. Patients with neuroblastoma due to the amplification of a 130-kb genomic DNA region containing the MYCN, MYCN antisense NCYM and lncUSMycN genes show poor prognosis. BET bromodomain inhibitors show anticancer efficacy against neuroblastoma partly by reducing MYCN gene transcription and N-Myc mRNA and protein expression. We have previously shown that the long nocoding RNA lncUSMycN upregulates N-Myc mRNA expression by binding to the RNA-binding protein NonO...
October 12, 2016: International Journal of Oncology
M Á Orellana, L Osiglio, P M Arnal, L R Pizzio
Titania hollow spheres were synthesized using silica nanospheres as the template. The core was removed using NaOH solution. They were subsequently impregnated with tungstophosphoric acid (TPA) solutions and annealed at two different temperatures (100 and 500 °C). These materials were characterized by several physicochemical techniques (XRD, BET, SEM, DRS, FT-IR, FT-Raman and (31)P MAS-NMR). The (31)P MAS-NMR and FT-IR characterization showed that the main species present in the samples was the [PW12O40](3-) anion, which was partially transformed into the [P2W21O71](6-) anion during the synthesis and drying step...
October 17, 2016: Photochemical & Photobiological Sciences
Rajamani Nagarajan, Pankaj Gupta, Poonam Singh, Pinki Chakraborty
Given the fact that the literature describing the intercalation of organic molecules in monometallic LDH systems is scarce, the present investigation is aimed at the generation of ethylene glycol intercalated Fe(II)-Fe(III) LDH with the objective of enhancing the surface area for further catalytic applications of industrially important and environmentally harmful organics. The solvothermal reaction of FeCl3 with urea in an ethylene glycol medium yielded a brown colored powder which was characterized employing a wide range of analytical techniques including high resolution powder X-ray diffraction (PXRD), scanning electron microscopy, thermal analysis, X-ray photo electron spectroscopy (XPS), elemental (C, H, N and S) analysis, UV-visible, photoluminescence spectroscopy measurements, BET surface area and pore-size analysis...
October 14, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Tingsheng Zhou, Yao Zhou, Ruguang Ma, Zhenzhen Zhou, Guanghui Liu, Qian Liu, Yufang Zhu, Jiacheng Wang
In situ formation of nitrogen-doped carbon nanoparticles on hollow carbon spheres (NHCSs) were successfully realised via a simple, scalable emulsion polymerization route using melamine as the nitrogen precursor, followed by thermal treatment at 1000 °C in N2. All NHCSs show large BET specific surface areas (648.2-837.7 cm(2) g(-1)) and pore volumes (0.91-1.16 cm(3) g(-1)), evidently superior to N-free hollow carbon spheres (HCSs) (524.3 cm(2) g(-1) and 0.48 cm(3) g(-1), respectively). This unique nanocomposite has hierarchical micro-/mesoporosity (1...
October 14, 2016: Nanoscale
Ronald Schilderink, Matthew Bell, Eleonora Reginato, Chris Patten, Inmaculada Rioja, Francisca W Hilbers, Pawel A Kabala, Kris A Reedquist, David F Tough, Paul Peter Tak, Rab K Prinjha, Wouter J de Jonge
Transcription of inflammatory genes is tightly regulated by acetylation and deacetylation of histone tails. An inhibitor of the acetylated-lysine reader bromodomain and extra-terminal domain (BET) proteins, I-BET151, is known to counteract the induction of expression of inflammatory genes in macrophages. We have investigated the effects of I-BET151 on dendritic cell function, including expression of co-stimulatory molecules and cytokines, and capacity for T cell activation. Treatment of mouse bone marrow derived dendritic cells (BMDC) and human monocyte derived DCs (mdDC) with I-BET151 reduced LPS-induced expression of co-stimulatory molecules, as well as the production of multiple cyokines and chemokines...
October 3, 2016: Molecular Immunology
Zhang Zhang, Li Liang, Dong Li, Lin Nong, Jumei Liu, Linlin Qu, Yalin Zheng, Bo Zhang, Ting Li
The loss of PRDM1 expression is common in extranodal NK/T-cell lymphoma, nasal type (EN-NK/T-NT), but the role of promoter methylation in silencing PRDM1 expression remains unclear. Hence, we performed pyrosequencing analysis to evaluate the promoter methylation of PRDM1 gene in vivo and in vitro, to analyze the association between methylation and its expression, and to assess cellular effects of PRDM1 reexpression. The promoter hypermethylation of PRDM1 gene was detected in 11 of 25 EN-NK/T-NT cases (44.0%) and NK92 and NKL cells...
October 5, 2016: Hematological Oncology
B Keith Payne, Jazmin L Brown-Iannuzzi, Chris Loersch
The effect of primes (i.e., incidental cues) on human behavior has become controversial. Early studies reported counterintuitive findings, suggesting that primes can shape a wide range of human behaviors. Recently, several studies failed to replicate some earlier priming results, raising doubts about the reliability of those effects. We present a within-subjects procedure for priming behavior, in which participants decide whether to bet or pass on each trial of a gambling game. We report 6 replications (N = 988) showing that primes consistently affected gambling decisions when the decision was uncertain...
October 2016: Journal of Experimental Psychology. General
Fabian Wunderlich, Daniel Memmert
The present study aims to investigate the ability of a new framework enabling to derive more detailed model-based predictions from ranking systems. These were compared to predictions from the bet market including data from the World Cups 2006, 2010, and 2014. The results revealed that the FIFA World Ranking has essentially improved its predictive qualities compared to the bet market since the mode of calculation was changed in 2006. While both predictors were useful to obtain accurate predictions in general, the world ranking was able to outperform the bet market significantly for the World Cup 2014 and when the data from the World Cups 2010 and 2014 were pooled...
August 11, 2016: Journal of Sports Sciences
Ayako Matsuki, Hiroaki Takatori, Sohei Makita, Masaya Yokota, Tomohiro Tamachi, Akira Suto, Kotaro Suzuki, Koichi Hirose, Hiroshi Nakajima
BACKGROUND: Innate lymphoid cells (ILCs) are emerging subsets of immune cells that produce large amounts of cytokines upon cytokine and/or alarmin stimulation. Recent studies have shown that T-bet plays pivotal roles in the development of ILC3s and ILC1s; however, the roles of T-bet in lung ILC2s remain unknown. OBJECTIVE: To determine the role of T-bet in ILC2-mediated airway inflammation. METHODS: The expression of T-bet in lung ILCs (defined as Thy1...
September 23, 2016: Journal of Allergy and Clinical Immunology
Kerstin Hogg
No abstract text is available yet for this article.
October 2016: Emergency Medicine Journal: EMJ
Robert D Lieberthal
Long-term health insurance provides consumers with protection against persistent, negative health shocks. While the stochastic rise in medical spending growth may make some health risks harder to insure, financial assets could act as a hedge for medical spending growth risk. The purpose of this research was to determine whether such hedges exist. The results of this study were two-fold. First, the asset classes with the strongest statistical evidence as hedges were bonds, not stocks. Second, any strategy to hedge medical spending growth involved shorting assets i...
August 2016: Appl Finance Account
Ramiro Vázquez, Simonetta Andrea Licandro, Lucile Astorgues-Xerri, Emanuele Lettera, Nicolò Panini, Michela Romano, Eugenio Erba, Paolo Ubezio, Ezia Bello, Roberta Libener, Sara Orecchia, Federica Grosso, María Eugenia Riveiro, Esteban Cvitkovic, Mohamed Bekradda, Maurizio D'Incalci, Roberta Frapolli
It has recently been reported that a large proportion of human malignant pleural mesothelioma (MPM) cell lines and patient tissue samples present high expression of the c-MYC oncogene. This gene drives several tumorigenic processes and is overexpressed in many cancers. Although c-MYC is a strategic target to restrain cancer processes, no drugs acting as c-MYC inhibitors are available. The novel thienotriazolodiazepine small-molecule bromodomain inhibitor OTX015/MK-8628 has shown potent antiproliferative activity accompanied by c-MYC downregulation in several tumor types...
September 4, 2016: International Journal of Cancer. Journal International du Cancer
Jingjun Li, Jing Ma, Guofeng Meng, Hong Lin, Sharon Wu, Jamie Wang, Jie Luo, Xiaohong Xu, David Tough, Matthew Lindon, Inma Rioja Pastor, Jing Zhao, Hongkang Mei, Rab Prinjha, Zhong Zhong
Neural stem cells and progenitor cells (NPCs) are increasingly appreciated to hold great promise for regenerative medicine to treat CNS injuries and neurodegenerative diseases. However, evidence for effective stimulation of neuronal production from endogenous or transplanted NPCs for neuron replacement with small molecules remains limited. To identify novel chemical entities/targets for neurogenesis, we had established a NPC phenotypic screen assay and validated it using known small-molecule neurogenesis inducers...
July 20, 2016: Stem Cell Research
Emeline Lawarée, Sébastien Gillet, Gwennaëlle Louis, Françoise Tilquin, Sophie Le Blastier, Pierre Cambier, Jean-Yves Matroule
Stress response to fluctuating environments often implies a time-consuming reprogramming of gene expression. In bacteria, the so-called bet hedging strategy, which promotes phenotypic stochasticity within a cell population, is the only fast stress response described so far(1). Here, we show that Caulobacter crescentus asymmetrical cell division allows an immediate bimodal response to a toxic metals-rich environment by allocating specific defence strategies to morphologically and functionally distinct siblings...
2016: Nature Microbiology
Shanshan Li, Quan Wan, Zonghua Qin, Yuhong Fu, Yuantao Gu
Puzzling aspects of the microporous structure of Stöber silica, including inconsistencies in the BET specific surface area and the long measurement time required for N2 adsorption, hinder further research on and potential applications of this material. In this work, Stöber silica samples prepared using systematic and detailed post-treatment methods were characterized by N2 adsorption, scanning electron microscopy, transmission electron microscopy, inductively coupled plasma optical emission spectrometry, elemental analysis, and Fourier transform infrared spectroscopy...
September 13, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Craig Ferguson, Body Richard
No abstract text is available yet for this article.
September 2016: Emergency Medicine Journal: EMJ
Michael Gottlieb, Harriet Edwards
This short-cut review was carried out to examine the evidence for the use of ultrasound in diagnosing shoulder dislocation in adult patients presenting to EDs. A literature search was carried out that found two relevant papers. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. The clinical bottom line is that ultrasound of the shoulder appears to have a very high sensitivity and specificity within this patient group...
September 2016: Emergency Medicine Journal: EMJ
Keisuke Yamamoto, Keisuke Tateishi, Yotaro Kudo, Mayumi Hoshikawa, Mariko Tanaka, Takuma Nakatsuka, Hiroaki Fujiwara, Koji Miyabayashi, Ryota Takahashi, Yasuo Tanaka, Hideaki Ijichi, Yousuke Nakai, Hiroyuki Isayama, Yasuyuki Morishita, Taku Aoki, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Masashi Fukayama, Kazuhiko Koike
Inhibitors of bromodomain and extraterminal domain (BET) proteins, a family of chromatin reader proteins, have therapeutic efficacy against various malignancies. However, the detailed mechanisms underlying the anti-tumor effects in distinct tumor types remain elusive. Here, we show a novel antitumor mechanism of BET inhibition in pancreatic ductal adenocarcinoma (PDAC). We found that JQ1, a BET inhibitor, decreased desmoplastic stroma, a hallmark of PDAC, and suppressed the growth of patient-derived tumor xenografts (PDX) of PDACs...
August 9, 2016: Oncotarget
Chengyue Zhang, Zheng-Yuan Su, Ling Wang, Limin Shu, Yuqing Yang, Yue Guo, Douglas Pung, Chas Bountra, Ah-Ng Kong
The neoplastic transformation of cells and inflammation are processes that contribute to tumor initiation. Recently, emerging evidence has suggested that epigenetic alterations are also implicated in the early stages of carcinogenesis. Therefore, potent small molecules targeting epigenetic regulators have been developed as novel cancer therapeutic and preventive strategies. Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that play key roles at the interface between chromatin modification and transcriptional regulation...
October 1, 2016: Biochemical Pharmacology
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