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https://www.readbyqxmd.com/read/29137609/a-comparative-content-analysis-of-media-reporting-of-sports-betting-in-australia-lessons-for-public-health-media-advocacy-approaches
#1
Jennifer L David, Samantha L Thomas, Melanie Randle, Steven J Bowe, Mike Daube
BACKGROUND: Harmful gambling is a significant public health issue. There has been widespread discussion in the Australian media about the extent and impact of sports betting on the Australian community, particularly relating to young men and children. Given the role that the media plays in influencing policy change and political agendas, and the acknowledgement that media based advocacy is a fundamental component of successful advocacy campaigns, this research aimed to investigate how different stakeholder groups discuss sports betting within the Australian print media...
November 14, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29113796/the-bet-brd-inhibitor-jq1-attenuates-diabetes-induced-cognitive-impairment-in-rats-by-targeting-nox4-nrf2-redox-imbalance
#2
Ershun Liang, Min Ma, Lei Wang, Xue Liu, Jinfeng Xu, Mingxiang Zhang, Ruixue Yang, Yuxia Zhao
Diabetes-induced oxidative damage is believed to play an important role in the development of cognitive dysfunction. In this study, the involvement of the Nox4-Nrf2 redox imbalance was investigated. STZ-induced diabetic rats exhibited obvious oxidative stress and apoptosis in the hippocampus assessed by augmentation of lipid peroxidation, positive TUNEL staining, elevated ratio of Bax/Bcl-2 and increased caspase 3 activity. Furthermore, hyperglycemia markedly increased Nox4 activity and reduced the activation of Nrf2 by suppressing its up-stream regulatory Akt as well as down-stream target HO-1...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29104468/extensively-disturbance-of-regulatory-t-cells-th17-cells-balance-in-stage-ii-pulmonary-sarcoidosis
#3
Jingjing Ding, Jinghong Dai, Hourong Cai, Qian Gao, Yanting Wen
BACKGROUND: Sarcoidosis is a systemic inflammatory disorder characterized by granulomas. Not enough evidences correlate the derangement of CD4+ T subsets, which have an impact on the therapeutic effects of corticosteroids, with the radiographical staging of sarcoidosis. Here we show the disturbance of CD4+ T subsets in newly diagnosed stage II pulmonary sarcoidosis, which is the most common stage in which corticosteroids treatment is used. MATERIALS AND METHODS: 39 newly diagnosed and treatment-naïve patients and 9 subjects after corticosteroids treatment were included...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29081776/innate-lymphoid-cells-in-intestinal-inflammation
#4
REVIEW
Alessandra Geremia, Carolina V Arancibia-Cárcamo
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine that encompasses Crohn's disease (CD) and ulcerative colitis. The cause of IBD is unknown, but the evidence suggests that an aberrant immune response toward the commensal bacterial flora is responsible for disease in genetically susceptible individuals. Results from animal models of colitis and human studies indicate a role for innate lymphoid cells (ILC) in the pathogenesis of chronic intestinal inflammation in IBD. ILC are a population of lymphocytes that are enriched at mucosal sites, where they play a protective role against pathogens including extracellular bacteria, helminthes, and viruses...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29061878/bet-2-should-children-with-sport-related-concussion-observe-strict-physical-rest-until-symptom-free
#5
Andrew C Kline
A short cut review was carried out to establish whether strict physical rest following sports related concussion in children is better than normal activity in reducing post-concussional symptoms. two recent systematic reviews presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. It is concluded that children who present with a sport-related concussion should have a brief period of cognitive and physical rest followed by a gradual increase in activity...
November 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29061876/bet-1-does-the-use-of-emollients-prevent-frostbite-to-the-face
#6
Emmy De Buck
A short cut review was carried out to establish whether routine use of emollients on the face reduced the incidence of frostbite in cold environments. 126 papers were found using the reported searches, of which three presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. It is concluded that the use of emollients on the face is not a good protection against frostbite and may even result in a higher risk...
November 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29044821/what-do-children-observe-and-learn-from-televised-sports-betting-advertisements-a-qualitative-study-among-australian-children
#7
Hannah Pitt, Samantha L Thomas, Amy Bestman, Mike Daube, Jeffrey Derevensky
OBJECTIVE: To explore children's awareness of sports betting advertising and how this advertising may influence children's attitudes, product knowledge and desire to try sports betting. METHODS: Semi-structured qualitative interviews were conducted with 48 children (8-16 years) from Melbourne, Victoria. The interview schedule explored children's recall and interpretations of sports betting advertising, strategies within advertisements that may appeal to children, children's product knowledge and understanding of betting terminology, and factors that may encourage gambling...
October 18, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29033951/sphingosine-1-phosphate-receptor-5-modulates-early-stage-processes-during-fibrogenesis-in-a-mouse-model-of-systemic-sclerosis-a-pilot-study
#8
Katrin G Schmidt, Martina Herrero San Juan, Sandra Trautmann, Lucija Berninger, Anja Schwiebs, Florian M Ottenlinger, Dominique Thomas, Frank Zaucke, Josef M Pfeilschifter, Heinfried H Radeke
Systemic sclerosis (SSc) is a rare multi-organ autoimmune disease characterized by progressive skin fibrosis. Inflammation, type 2 immunity, and fibrogenic processes are involved in disease development and may be affected by sphingolipids. However, details about early-stage pathophysiological mechanisms and implicated mediators remain elusive. The sphingolipid sphingosine-1-phosphate (S1P) is elevated in the sera of SSc patients, and its receptor S1P5 is expressed in skin tissue. Nevertheless, almost nothing is known about the dermatological contribution of S1P5 to inflammatory and pro-fibrotic processes leading to the pathological changes seen in SSc...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28991225/super-enhancers-define-a-proliferative-pgc-1%C3%AE-expressing-melanoma-subgroup-sensitive-to-bet-inhibition
#9
K A Gelato, L Schöckel, O Klingbeil, T Rückert, R Lesche, J Toedling, E Kalfon, M Héroult, P Lejeune, U Mönning, A E Fernández-Montalván, S Bäurle, S Siegel, B Haendler
Metabolic changes are linked to epigenetic reprogramming and play important roles in several tumor types. PGC-1α is a transcriptional coactivator controlling mitochondrial biogenesis and is linked to oxidative phosphorylation. We provide evidence that melanoma models with elevated PGC-1α levels are characteristic of the proliferative phenotype and are sensitive to bromodomain and extra-terminal domain (BET) inhibitor treatment. A super-enhancer region highly occupied by the BET family member BRD4 was identified for the PGC-1α gene...
October 9, 2017: Oncogene
https://www.readbyqxmd.com/read/28971711/epigenetic-regulation-in-bacterial-infections-targeting-histone-deacetylases
#10
Aleksander M Grabiec, Jan Potempa
Pathogens have developed sophisticated strategies to evade the immune response, among which manipulation of host cellular epigenetic mechanisms plays a prominent role. In the last decade, modulation of histone acetylation in host cells has emerged as an efficient strategy of bacterial immune evasion. Virulence factors and metabolic products of pathogenic microorganisms alter expression and activity of histone acetyltransferases (HATs) and histone deacetylases (HDACs) to suppress transcription of host defense genes through epigenetic changes in histone acetylation marks...
October 3, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28935540/new-crosslinked-chitosan-graft-poly-n-vinyl-2-pyrrolidone-for-the-removal-of-cu-ii-ions-from-aqueous-solutions
#11
Zetty Azalea Sutirman, Mohd Marsin Sanagi, Juhanni Abd Karim, Ahmedy Abu Naim, Wan Aini Wan Ibrahim
Crosslinked chitosan beads were grafted with N-vinyl-2-pyrrolidone (NVP) using ammonium persulfate (APS) as free radical initiator. Important variables on graft copolymerization such as temperature, reaction time, concentration of initiator and concentration of monomer were optimized. The results revealed optimum conditions for maximum grafting of NVP on 1g crosslinked chitosan as follows: reaction temperature, 60°C; reaction time, 2h and concentrations of APS and NVP of 2.63×10(-1)M and 26.99×10(-1)M, respectively...
September 18, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28886863/critical-role-of-mammalian-target-of-rapamycin-for-il-10-dendritic-cell-induction-by-a-flagellin-a%C3%A2-conjugate-in-preventing-allergic-sensitization
#12
Stefan Schülke, Anna-Helena Fiedler, Ann-Christine Junker, Adam Flaczyk, Sonja Wolfheimer, Andrea Wangorsch, Anke Heinz, Hendrik Beckert, Birgit Nagl, Barbara Bohle, Stefan Vieths, Masako Toda, Stephan Scheurer
BACKGROUND: Fusion proteins incorporating the Toll-like receptor 5 ligand flagellin are currently undergoing clinical trials as vaccine candidates for many diseases. OBJECTIVE: We studied the mechanisms of immune modulation by a flagellin:allergen fusion protein containing the Toll-like receptor 5 ligand flagellin A from Listeria monocytogenes and the birch pollen allergen Bet v 1 (recombinant flagellin A [rFlaA]:Betv1). METHODS: BALB/c mice were vaccinated with rFlaA:Betv1 in an experimental Bet v 1 sensitization model...
August 25, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28875499/the-intestinal-microbiota-determines-the-colitis-inducing-potential-of-t-bet-deficient-th-cells-in-mice
#13
Jakob Zimmermann, Pawel Durek, Anja A Kühl, Florian Schattenberg, Patrick Maschmeyer, Francesco Siracusa, Katrin Lehmann, Kerstin Westendorf, Melanie Weber, René Riedel, Susann Müller, Andreas Radbruch, Hyun-Dong Chang
Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of naïve T cells into Rag(-/-) mice requires expression of the transcription factor T-bet by the T cells. Here, we formally show that the intestinal microbiota composition of the Rag(-/-) recipient determines whether or not T-bet-deficient Th cells can induce colitis and we have resolved the differences of the two microbiomes, permissive or non-permissive to T-bet-independent colitis. Our data highlight the dominance of the microbiota over particular T cell differentiation programs in the pathogenesis of chronic intestinal inflammation...
September 6, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28863383/acetylenic-derivative-of-betulin-induces-apoptosis-in-endometrial-adenocarcinoma-cell-line
#14
Lukasz Szoka, Ewa Karna, Kornelia Hlebowicz-Sarat, Jacek Karaszewski, Stanisław Boryczka, Jerzy A Palka
Since betulin (Bet) and its acetylenic derivative, 28-O-propynoylbetulin (proBet) were shown to induce apoptosis in several cancer cell lines, we studied the mechanism of this process in human endometrial adenocarcinoma cells (EA). Previous studies suggested that this group of compounds affect prolidase activity (proline releasing enzyme from imidodipeptides) and collagen biosynthesis (proline utilizing process) providing substrate (proline) for proline oxidase (POX) dependent apoptosis. Here we provide evidence that Bet and proBet exhibit prolidase-inducing activity in EA cell line...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28840412/gambling-participation-expenditure-and-risk-of-harm-in-australia-1997-1998-and-2010-2011
#15
Andrew Richard Armstrong, Anna Thomas, Max Abbott
Gambling-related harm results primarily from financial losses. Internationally Australia continues to rank as the largest spending nation per capita on gambling products. This would suggest that Australian gamblers are at disproportionately high risk of harm despite almost two decades of industry scrutiny and regulation, and investment in research, treatment and education programs. However, declines in participation rates, per capita expenditure, household expenditure, national disposable income spent on gambling and problem gambling rates have been cited as evidence that fewer people are gambling, that gamblers are spending less, and that gambling safety in Australia has improved...
August 24, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28827294/bet-2-can-procalcitonin-accurately-diagnose-serious-bacterial-infection-in-emergency-department-patients-with-sirs
#16
Joel Wilson, Jerry Baskerville, Sahar Zarabi
A shortcut review was carried out to establish whether serum procalcitonin levels can be used to identify serious bacterial infection in ED patients with undifferentiated SIRS. 14 papers presented the best evidence to answer the clinical question. The review concludes that raised procalcitonin levels are associated with bacteraemia; however, there are no clinical management studies addressing this question in ED patients with SIRS.
September 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28827293/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#17
Kerstin de Wit
No abstract text is available yet for this article.
September 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28827292/bet-1-sirs-criteria-as-a-way-of-predicting-mortality-in-acute-pancreatitis
#18
Joel Wilson, Sahar Zarabi
A shortcut review was carried out to establish whether the presence of systemic inflammatory response criteria in emergency department patients with pancreatitis is predictive of the risk of death. Eight papers presented the best evidence to answer the clinical question. The review concludes that the presence of SIRS in emergency department patients with pancreatitis is associated with a higher risk of mortality.
September 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28811967/il-18-receptor-marks-functional-cd8-t-cells-in-non-small-cell-lung-cancer
#19
Eleonora Timperi, Chiara Focaccetti, Daniela Gallerano, Mariangela Panetta, Sheila Spada, Enzo Gallo, Paolo Visca, Federico Venuta, Daniele Diso, Arsela Prelaj, Flavia Longo, Francesco Facciolo, Paola Nisticò, Vincenzo Barnaba
IL-18 is an inflammasome-related cytokine, member of the IL-1 family, produced by a wide range of cells in response to signals by several pathogen- or damage-associated molecular patterns. It can be highly represented in tumor patients, but its relevance in human cancer development is not clear. In this study, we provide evidence that IL-18 is principally expressed in tumor cells and, in concert with other conventional Th1 cell-driven cytokines, has a pivotal role in establishing a pro-inflammatory milieu in the tumor microenvironment of human non-small cell lung cancer (NSCLC)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28766336/kish-graphite-flakes-as-a-cathode-material-for-an-aluminum-chloride-graphite-battery
#20
Shutao Wang, Kostiantyn V Kravchyk, Frank Krumeich, Maksym V Kovalenko
Nonaqueous, ionic liquid-based aluminum chloride-graphite batteries (AlCl3-GBs) are a highly promising post-Li-ion technology for low-cost and large-scale storage of electricity because these batteries feature exclusively highly abundant chemical elements and simple fabrication methods. In this work, we demonstrate that synthetic kish graphite, which is a byproduct of steelmaking, can be used as a cathode in AlCl3-GB and exhibits high capacities of ≤142 mAh g(-1). The comprehensive characterization of kish graphite flakes and other forms of graphite by X-ray diffraction, Raman spectroscopy, and Brunauer-Emmett-Teller surface area analysis provides solid evidence that the exceptional electrochemical behavior of kish graphite flakes is mainly determined by the high structural order of carbon atoms, a low level of defects, and a unique "crater morphology"...
August 30, 2017: ACS Applied Materials & Interfaces
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