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https://www.readbyqxmd.com/read/29764785/balloon-eustachian-tuboplasty-systematic-review-of-long-term-outcomes-and-proposed-indications
#1
Veera Luukkainen, Ilkka Kivekäs, Juha Silvola, Jussi Jero, Saku T Sinkkonen
Balloon Eustachian tuboplasty (BET) aims to improve the function of the Eustachian tube (ET). The objective of this study was to review the long-term outcome of BET and present the process and results of outlining indications for BET by the Finnish Otosurgical Society. The literature review is based on a database search performed in May 2017. The search resulted in 100 individual articles, which were screened for relevance. Five articles fulfilled the inclusion criteria (follow-up ≥12 months). Five additional articles (follow-up, 6-11 months) were analyzed to obtain supportive information...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29760540/ambiguous-roles-of-innate-lymphoid-cells-in-chronic-development-of-liver-diseases
#2
REVIEW
Yue Shen, Jing Li, Si-Qi Wang, Wei Jiang
Innate lymphoid cells (ILCs) are defined as a distinct arm of innate immunity. According to their profile of secreted cytokines and lineage-specific transcriptional factors, ILCs can be categorized into the following three groups: group 1 ILCs (including natural killer (NK) cells and ILC1s) are dependent on T-bet and can produce interferon-γ; group 2 ILCs (ILC2s) are dependent on GATA3 and can produce type 2 cytokines, including interleukin (IL)-5 and IL-13; and, group 3 ILCs (including lymphoid tissue-like cells and ILC3s) are dependent on RORγt and can produce IL-22 and IL-17...
May 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29755274/nut-carcinoma-of-the-sinonasal-tract-infiltrating-the-orbit-in-a-man-with-birdshot-chorioretinitis
#3
Wesley Chan, Martin J Bullock, Arif F Samad, Curtis W Archibald, J Godfrey Heathcote
A 48-year-old man with a history of birdshot chorioretinitis presented with blurry vision, retro-bulbar pain and sinusitis. Though visual acuity was unaffected, he had left optic disc oedema and mild restriction of left eye abduction. His symptoms progressed quickly, with diplopia in primary gaze, epistaxis from his left nostril, and a left relative afferent pupillary defect (RAPD). On computed tomography, there was a mass in the nasal cavity that extended through the left cribriform plate and lamina papyracea and posteriorly into the optic canal...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29751318/characterizing-the-capacity-of-hyporheic-sediments-to-attenuate-groundwater-nitrate-loads-by-adsorption
#4
Aminreza Meghdadi
Nitrate has been recognized as a global threat to environmental health. In this regard, the hyporheic zone (saturated media beneath and adjacent to the stream bed) plays a crucial role in attenuating groundwater nitrate, prior to discharge into surface water. While different nitrate removal pathways have been investigated over recent decades, the adsorption capacity of hyporheic sediments under natural conditions has not yet been identified. In this study, the natural attenuation capacity of the hyporheic-sediments of the Ghezel-Ozan River, located in the north-west of Iran, was determined...
May 2, 2018: Water Research
https://www.readbyqxmd.com/read/29674981/comparative-effect-of-collaborative-care-pain-medication-and-duloxetine-in-the-treatment-of-major-depressive-disorder-and-comorbid-sub-chronic-pain-results-of-an-exploratory-randomized-placebo-controlled-multicenter-trial-cc-paindip
#5
Eric W de Heer, Jack Dekker, Aartjan T F Beekman, Harm W J van Marwijk, Tjalling J Holwerda, Pierre M Bet, Joost Roth, Lotte Timmerman, Christina M van der Feltz-Cornelis
Objective: Evidence exists for the efficacy of collaborative care (CC) for major depressive disorder (MDD), for the efficacy of the consequent use of pain medication against pain, and for the efficacy of duloxetine against both MDD and neuropathic pain. Their relative effectiveness in comorbid MDD and pain has never been established so far. This study explores the effectiveness of CC with pain medication and duloxetine, and CC with pain medication and placebo, compared with duloxetine alone, on depressive and pain symptoms...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29674946/betting-forex-trading-and-fantasy-gaming-sponsorships-a-responsible-marketing-inquiry-into-the-gamblification-of-english-football
#6
Hibai Lopez-Gonzalez, Mark D Griffiths
Environmental stimuli in the form of marketing inducements to gamble money on sports have increased in recent years. The purpose of the present paper is to tackle the extended definition of the gamblification of sport using sponsorship and partnership deals of gambling, forex trading, and fantasy gaming as a proxy for assessing its environmental impact. Using data about sponsorship deals from English Football Premier League, the paper builds on the evidence of English football's gamblification process to discuss the impact that the volume, penetration, and marketing strategies of sports betting might have on public health and well-being...
2018: International Journal of Mental Health and Addiction
https://www.readbyqxmd.com/read/29667516/comparison-on-surface-properties-and-desulfurization-of-mno-2-and-pyrolusite-blended-activated-carbon-by-steam-activation
#7
Guochen Zhang, Xin Zhao, Ping Ning, Danni Yang, Xia Jiang, Wenju Jiang
In this study, MnO2 and pyrolusite were used as the catalysts to prepare modified activated carbon, i.e., AC-Mn and AC-P, respectively, from coals by blending method and steam activation. The BET results indicated that the AC-P had higher surface areas and micropore volumes than the AC-Mn with the same blending ratio. The relative contents of basic functional groups (i.e. C = O, π-π*) on AC-P were slightly lower than those on AC-Mn, while both contained the same main metal species, i.e. MnO. The desulfurization results showed that with 3 wt% of blending ratio, AC-Mn3 and AC-P3 had higher sulfur capacities at 220 and 205 mg/g, respectively, which were much higher than blank one (149...
April 18, 2018: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29574611/betting-on-life-associations-between-significant-life-events-and-gambling-trajectories-among-gamblers-with-the-intent-to-quit
#8
Alexandra Godinho, Vladyslav Kushnir, David C Hodgins, Christian S Hendershot, John A Cunningham
Considerable evidence has suggested that problem gambling may be transitory and episodic, with gamblers routinely moving in and out of clinical thresholds. Findings in qualitative and quantitative studies have converged on identifying preliminary evidence for the role of life events as motivators and contributing factors for gambling changes over time. The aim of this study was to conduct an exploratory analysis of the relationship between life events, their respective experience as positive or negative, and gambling trajectories among problem gamblers intending to quit...
March 24, 2018: Journal of Gambling Studies
https://www.readbyqxmd.com/read/29559542/bet-1-can-induced-hypertension-improve-outcome-following-acute-traumatic-spinal-cord-injury
#9
Elliott Bertram-Ralph, Daniel Horner
A shortcut review was carried out to establish whether augmentation of blood pressure to a high mean arterial pressure (MAP) target in the early phase of traumatic spinal cord injury (SCI) could lead to improvements in morbidity or mortality. 23 directly relevant papers were found using the reported search strategy. Of these, two systematic reviews collated the best evidence to answer the clinical question. The author, date and country of publication; patient group studied; study type; relevant outcomes; results and study weaknesses of the best papers are tabulated...
April 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29557545/gambling-risk-groups-are-not-all-the-same-risk-factors-amongst-sports-bettors
#10
Alex M T Russell, Nerilee Hing, En Li, Peter Vitartas
Sports betting is increasing worldwide, with an associated increase in sports betting-related problems. Previous studies have examined risk factors for problem gambling amongst sports bettors and have identified demographic, behavioural, marketing, normative and impulsiveness factors. These studies have generally compared those in problem gambling, or a combination of moderate risk and problem gambling, groups to non-problem gamblers, often due to statistical power issues. However, recent evidence suggests that, at a population level, the bulk of gambling-related harm stems from low risk and moderate risk gamblers, rather than problem gamblers...
March 20, 2018: Journal of Gambling Studies
https://www.readbyqxmd.com/read/29542201/template-free-synthesis-of-hierarchical-ssz-13-microspheres-with-high-mto-catalytic-activity
#11
Liancheng Bing, Aixiu Tian, Fang Wang, Kaifeng Yi, Xingyuan Sun, Guangjian Wang
Hierarchical SSZ-13 microspheres with abundant mesoporous channels have been successfully synthesized by addition of calcined SSZ-13 crystals in the starting gel in the absence of any organic templates. This strategy not only remarkably reduces the production cost and environmental pollution but also significantly decreases the crystallization time as well as evidently reducing the zeolite crystal sizes in many cases. The synthesized sample was characterized by XRD, BET, ICP, SEM, TEM, TG, and NH3-TPD, which indicates that the organic template free synthesized SSZ-13 exhibits high crystallinity, textural properties, and acidity...
March 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29541890/population-heterogeneity-in-microbial-bioprocesses-origin-analysis-mechanisms-and-future-perspectives
#12
REVIEW
Anna-Lena Heins, Dirk Weuster-Botz
Population heterogeneity is omnipresent in all bioprocesses even in homogenous environments. Its origin, however, is only so well understood that potential strategies like bet-hedging, noise in gene expression and division of labour that lead to population heterogeneity can be derived from experimental studies simulating the dynamics in industrial scale bioprocesses. This review aims at summarizing the current state of the different parts of single cell studies in bioprocesses. This includes setups to visualize different phenotypes of single cells, computational approaches connecting single cell physiology with environmental influence and special cultivation setups like scale-down reactors that have been proven to be useful to simulate large-scale conditions...
March 14, 2018: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29534238/targeting-epigenetic-dna-and-histone-modifications-to-treat-kidney-disease
#13
Miguel Fontecha-Barriuso, Diego Martin-Sanchez, Olga Ruiz-Andres, Jonay Poveda, Maria Dolores Sanchez-Niño, Lara Valiño-Rivas, Marta Ruiz-Ortega, Alberto Ortiz, Ana Belén Sanz
Epigenetics refers to heritable changes in gene expression patterns not caused by an altered nucleotide sequence, and includes non-coding RNAs and covalent modifications of DNA and histones. This review focuses on functional evidence for the involvement of DNA and histone epigenetic modifications in the pathogenesis of kidney disease and the potential therapeutic implications. There is evidence of activation of epigenetic regulatory mechanisms in acute kidney injury (AKI), chronic kidney disease (CKD) and the AKI-to-CKD transition of diverse aetiologies, including ischaemia-reperfusion injury, nephrotoxicity, ureteral obstruction, diabetes, glomerulonephritis and polycystic kidney disease...
March 9, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29524485/effective-removal-of-copper-from-aqueous-solutions-by-modified-magnetic-chitosan-graphene-oxide-nanocomposites
#14
Hossein Hosseinzadeh, Sonia Ramin
In the present work, a novel magnetic chitosan/graphene oxide nanocomposite (MCGON) was synthesized for the removal of Cu2+ from aqueous solutions. The adsorbent was composed of graphene oxide (GO) modified by ethylenediamine (ED), Fe3 O4 nanoparticles and chitosan-g-poly(acrylic acid-co-2-acrylamido-2-methylpropane sulfonic acid) copolymer. The composition and structure of adsorbents were characterized by FTIR, SEM, EDX, XRD, TGA, VSM and BET analysis. The magnetic MCGON with a high specific surface area of (132...
July 1, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29494505/novel-precursor-derived-meso-macroporous-tio%C3%A2-sioc-nanocomposites-with-highly-stable-anatase-nanophase-providing-visible-light-photocatalytic-activity-and-superior-adsorption-of-organic-dyes
#15
Eranezhuth Wasan Awin, Abhijeet Lale, Kollamala Chellappan Nair Hari Kumar, Umit Bilge Demirci, Samuel Bernard, Ravi Kumar
Titania (TiO₂) is considered to have immense potential as a photocatalyst, the anatase phase in particular. There have been numerous attempts to push the limits of its catalytic activity to higher wavelengths to harness the visible electromagnetic radiation. Most of the investigations till date have been restricted to fine-tuning the bandgap by doping, control of defect chemistry at the surface and several to first principle simulations either with limited success or success at the cost of complexities in processing...
March 1, 2018: Materials
https://www.readbyqxmd.com/read/29475942/induction-of-autophagy-by-pi3k-mtor-and-pi3k-mtor-brd4-inhibitors-suppresses-hiv-1-replication
#16
Grant R Campbell, Rachel S Bruckman, Shayna D Herns, Shweta Joshi, Donald L Durden, Stephen A Spector
In this study, we investigated the effects of the dual phosphatidylinositol 3-kinase/mechanistic target of rapamycin (PI3K/MTOR) inhibitor dactolisib (NVP-BEZ235), the PI3K/MTOR/bromodomain-containing protein 4 (BRD4) inhibitor SF2523, and the bromodomain and extra terminal domain inhibitor JQ1 on the productive infection of primary macrophages with human immunodeficiency type-1 (HIV). These inhibitors did not alter the initial susceptibility of macrophages to HIV infection. However, dactolisib, JQ1, and SF2523 all decreased HIV replication in macrophages in a dose-dependent manner via degradation of intracellular HIV through autophagy...
April 20, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29465625/spinal-bromodomain-containing-protein-4-contributes-to-neuropathic-pain-induced-by-hiv-glycoprotein-120-with-morphine-in-rats
#17
Keiya Takahashi, Hyun Yi, Ching-Hang Liu, Shue Liu, Yuta Kashiwagi, Dennis J Patin, Shuanglin Hao
The symptoms of HIV-sensory neuropathy are dominated by neuropathic pain. Recent data show that repeated use of opiates enhances the chronic pain states in HIV patients. Limited attention has so far been devoted to exploring the exact pathogenesis of HIV painful disorder and opiate abuse in vivo, for which there is no effective treatment. Bromodomain-containing protein 4 (Brd4) is a member of the bromodomain and extraterminal domain protein (BET) family and functions as a chromatin 'reader' that binds acetylated lysines in histones in brain neurons to mediate the transcriptional regulation underlying learning and memory...
April 11, 2018: Neuroreport
https://www.readbyqxmd.com/read/29463605/phenazines-regulate-nap-dependent-denitrification-in-pseudomonas-aeruginosa-biofilms
#18
Yu-Cheng Lin, Matthew D Sekedat, William Cole Cornell, Gustavo M Silva, Chinweike Okegbe, Alexa Price-Whelan, Christine Vogel, Lars E P Dietrich
Microbes in biofilms face the challenge of substrate limitation. In particular, cells in Pseudomonas aeruginosa biofilms growing in the laboratory or during host colonization often become limited for oxygen. Previously we found that phenazines, antibiotics produced by P. aeruginosa , balance the intracellular redox state for cells in biofilms. Here, we show that genes involved in denitrification are induced in phenazine-null (Δ phz ) mutant biofilms grown under an aerobic atmosphere, even in the absence of nitrate...
February 20, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29459733/conditional-toxicity-and-synergy-drive-diversity-among-antibacterial-effectors
#19
Kaitlyn D LaCourse, S Brook Peterson, Hemantha D Kulasekara, Matthew C Radey, Jungyun Kim, Joseph D Mougous
Bacteria in polymicrobial habitats contend with a persistent barrage of competitors, often under rapidly changing environmental conditions 1 . The direct antagonism of competitor cells is thus an important bacterial survival strategy 2 . Towards this end, many bacterial species employ an arsenal of antimicrobial effectors with multiple activities; however, the benefits conferred by the simultaneous deployment of diverse toxins are unknown. Here we show that the multiple effectors delivered to competitor bacteria by the type VI secretion system (T6SS) of Pseudomonas aeruginosa display conditional efficacy and act synergistically...
April 2018: Nature Microbiology
https://www.readbyqxmd.com/read/29457302/innate-lymphoid-cells-at-the-human-maternal-fetal-interface-in-spontaneous-preterm-labor
#20
Yi Xu, Roberto Romero, Derek Miller, Pablo Silva, Bogdan Panaitescu, Kevin R Theis, Afrah Arif, Sonia S Hassan, Nardhy Gomez-Lopez
PROBLEM: Pathological inflammation is causally linked to preterm labor and birth, the leading cause of neonatal morbidity and mortality worldwide. Our aims were to investigate whether (i) the newly described family of innate lymphoid cells (ILCs) was present at the human maternal-fetal interface and (ii) ILC inflammatory subsets were associated with the pathological process of preterm labor. METHODS OF STUDY: Decidual leukocytes were isolated from women with preterm or term labor as well as from gestational age-matched non-labor controls...
February 19, 2018: American Journal of Reproductive Immunology: AJRI
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