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https://www.readbyqxmd.com/read/27903272/inhibition-of-bromodomain-and-extra-terminal-bet-proteins-increases-nkg2d-ligand-mica-expression-and-sensitivity-to-nk-cell-mediated-cytotoxicity-in-multiple-myeloma-cells-role-of-cmyc-irf4-mir-125b-interplay
#1
Maria Pia Abruzzese, Maria Teresa Bilotta, Cinzia Fionda, Alessandra Zingoni, Alessandra Soriani, Elisabetta Vulpis, Cristiana Borrelli, Beatrice Zitti, Maria Teresa Petrucci, Maria Rosaria Ricciardi, Rosa Molfetta, Rossella Paolini, Angela Santoni, Marco Cippitelli
BACKGROUND: Anti-cancer immune responses may contribute to the control of tumors after conventional chemotherapy, and different observations have indicated that chemotherapeutic agents can induce immune responses resulting in cancer cell death and immune-stimulatory side effects. Increasing experimental and clinical evidence highlight the importance of natural killer (NK) cells in immune responses toward multiple myeloma (MM), and combination therapies able to enhance the activity of NK cells against MM are showing promise in treating this hematologic cancer...
December 1, 2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27886644/oral-administration-with-diosgenin-enhances-the-induction-of-intestinal-t-helper-1-like-regulatory-t-cells-in-a-murine-model-of-food-allergy
#2
Chung-Hsiung Huang, Chia-Chi Wang, Yu-Jin Lin, Masatoshi Hori, Tong-Rong Jan
Although the development of T helper (Th)1-like regulatory T (Treg) cells under Th1 inflammatory conditions has been reported, the role of Th1-like Treg cells in Th2 allergic responses remains mostly unclear. We previously demonstrated that diosgenin, the major sapogenin contained in the Chinese yam, attenuated food allergy and augmented Th1 and Treg immune responses. In this study, we hypothesized that diosgenin may enhance the induction of Th1-like Treg cells in the gut of mice with food allergy. Ovalbumin (OVA)-sensitized BALB/c mice were gavaged daily with diosgenin and received repeatedly intragastric ovalbumin challenges to induce intestinal allergic responses...
November 22, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27864394/bet-2-low-dose-ketamine-for-acute-pain-in-the-ed
#3
Colby Duncan, Brad Riley
A short cut review was carried out to establish whether low-dose ketamine is better than morphine at safely and effectively reducing pain scores in ED patients with acute pain who do not respond to conventional therapies. One hundred and thirty-two papers were found using the reported searches, of these three presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these best papers are tabulated...
December 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27864393/towards-evidence-based-emergency-medicine-best-bets-from-the-manchester-royal-infirmary
#4
Kevin C Mackway-Jones
No abstract text is available yet for this article.
December 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27864392/bet-1-trimethoprim-sulfamethoxazole-in-uncomplicated-skin-abscess
#5
Reece Baker, Jason Seamon
A short cut review was carried out to establish whether incision and drainage followed by treatment with oral trimethoprim-sulfamethoxazole is better than incision and drainage alone at treating patients with uncomplicated skin abscesses. One hundred and ninety-seven papers were found using the reported searches, of which three presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated...
December 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27835928/population-based-national-prevalence-of-thyroid-dysfunction-in-spain-and-associated-factors-di-bet-es-study
#6
Sergio Valdes, Cristina Maldonado-Araque, Ana Lago-Sampedro, J Antonio Lillo, Eduardo Garcia-Fuentes, Vidal Perez, Carolina Gutierrez-Repiso, Pilar Ocon-Sanchez, Albert Goday-Arno, Ines Urrutia, Laura Pelaez, Alfonso Calle-Pascual, Elena Bordiú, Luis Castaño, Conxa Castell, Elias Delgado Álvarez, Edelmiro Menendez, Josep Franch, Sonia Gaztambide, Joan Girbés, Emilio Ortega, Alfonso Lopez-Alba, Felipe J Chaves, Joan Vendrell, Matilde Rodriguez Chacon, Federico Soriguer, Gemma Rojo-Martinez
BACKGROUND: The aim of this study was to investigate the national prevalence of thyroid dysfunction in Spain, and its association with various clinical, environmental and demographic variables. METHODS: The present report includes 4554 people (42.4% men) with a mean age of 50 years (range 18-93 years) participants in a national, cross-sectional, population-based survey conducted in 2009-10. Data gathered included clinical and demographic characteristics, physical examination and blood sampling...
November 11, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27810538/optimum-reaction-ratio-of-coal-fly-ash-to-blast-furnace-cement-for-effective-removal-of-hydrogen-sulfide
#7
Satoshi Asaoka, Hideo Okamura, Kyunghoi Kim, Yuzuru Hatanaka, Kenji Nakamoto, Kazutoshi Hino, Takahito Oikawa, Shinjiro Hayakawa, Tetsuji Okuda
Reducing hydrogen sulfide concentration in eutrophic marine sediments is crucial to maintaining healthy aquatic ecosystems. Managing fly ash, 750 million tons of which is generated annually throughout the world, is another serious environmental problem. In this study, we develop an approach that addresses both these issues by mixing coal fly ash from coal-fired power plants with blast furnace cement to remediate eutrophic sediments. The purpose of this study is to optimize the mixing ratio of coal fly ash and blast furnace cement to improve the rate of hydrogen sulfide removal based on scientific evidence obtained by removal experiments and XAFS, XRD, BET, and SEM images...
October 27, 2016: Chemosphere
https://www.readbyqxmd.com/read/27803105/bet-inhibitors-suppress-aldh-activity-by-targeting-aldh1a1-super-enhancer-in-ovarian-cancer
#8
Yuhki Yokoyama, Hengrui Zhu, Jeong Heon Lee, Andrew V Kossenkov, Sherry Y Wu, Jayamanna M Wickramasinghe, Xiangfan Yin, Katherine C Palozola, Alessandro Gardini, Louise C Showe, Kenneth S Zaret, Qin Liu, David Speicher, Jose R Conejo-Garcia, James E Bradner, Zhiguo Zhang, Anil K Sood, Tamas Ordog, Benjamin G Bitler, Rugang Zhang
The emergence of tumor cells with certain stem-like characteristics, such as high aldehyde dehydrogenase (ALDH) activity due to ALDH1A1 expression, contributes to chemotherapy resistance and tumor relapse. However, clinically applicable inhibitors of ALDH activity have not been reported. There is evidence to suggest that epigenetic regulation of stem-related genes contributes to chemotherapy efficacy. Here, we show that bromodomain and extraterminal (BET) inhibitors suppress ALDH activity by abrogating BRD4-mediated ALDH1A1 expression through a super-enhancer element and its associated enhancer RNA...
November 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/27803062/rescue-of-tolerant-cd8-t-cells-during-cancer-immunotherapy-with-il2-antibody-complexes
#9
Lauryn E Klevorn, Melissa M Berrien-Elliott, Jinyun Yuan, Lindsey M Kuehm, Gregory D Felock, Sean A Crowe, Ryan M Teague
Interleukin-2 (IL2) was among the earliest reagents used for cancer immunotherapy due to its ability to support the survival and function of tumor-reactive T cells. However, treatment with IL2 is accompanied by off-target toxicity and low response rates in patients. In mouse models, these issues are largely overcome when IL2 is administered as a cytokine/antibody complex (IL2c). The complex has a longer serum half-life and can be designed for preferential cytokine delivery to specific cells of interest. Early studies showed IL2c could boost antitumor immunity in mice by activating tumor-reactive CD8(+) T cells...
December 2016: Cancer Immunology Research
https://www.readbyqxmd.com/read/27797555/correction-to-payne-et-al-2016
#10
(no author information available yet)
Reports an error in "Replicable effects of primes on human behavior" by B. Keith Payne, Jazmin L. Brown-Iannuzzi and Chris Loersch (Journal of Experimental Psychology: General, 2016[Oct], Vol 145[10], 1269-1279). (The following abstract of the original article appeared in record 2016-46925-002.) The effect of primes (i.e., incidental cues) on human behavior has become controversial. Early studies reported counterintuitive findings, suggesting that primes can shape a wide range of human behaviors. Recently, several studies failed to replicate some earlier priming results, raising doubts about the reliability of those effects...
October 31, 2016: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/27775716/potent-and-selective-bivalent-inhibitors-of-bet-bromodomains
#11
Michael J Waring, Huawei Chen, Alfred A Rabow, Graeme Walker, Romel Bobby, Scott Boiko, Rob H Bradbury, Rowena Callis, Edwin Clark, Ian Dale, Danette L Daniels, Austin Dulak, Liz Flavell, Geoff Holdgate, Thomas A Jowitt, Alexey Kikhney, Mark McAlister, Jacqui Méndez, Derek Ogg, Joe Patel, Philip Petteruti, Graeme R Robb, Matthew B Robers, Sakina Saif, Natalie Stratton, Dmitri I Svergun, Wenxian Wang, David Whittaker, David M Wilson, Yi Yao
Proteins of the bromodomain and extraterminal (BET) family, in particular bromodomain-containing protein 4 (BRD4), are of great interest as biological targets. BET proteins contain two separate bromodomains, and existing inhibitors bind to them monovalently. Here we describe the discovery and characterization of probe compound biBET, capable of engaging both bromodomains simultaneously in a bivalent, in cis binding mode. The evidence provided here was obtained in a variety of biophysical and cellular experiments...
October 24, 2016: Nature Chemical Biology
https://www.readbyqxmd.com/read/27774624/bet-bromodomain-suppression-inhibits-vascular-inflammation-by-blocking-nf-%C3%AE%C2%BAb-and-mapk-activation
#12
Mingcheng Huang, Shan Zeng, Yaoyao Zou, Maohua Shi, Qian Qiu, Youjun Xiao, Guoqiang Chen, Xiuyan Yang, Liuqin Liang, Hanshi Xu
BACKGROUND AND PURPOSE: Increasing evidence indicates the critical role of bromodomain and extra-terminal domain (BET) proteins in regulating immune and inflammatory responses, however, their contribution to vascular inflammation remains to be defined. In this study, we investigated the effect of BET bromodomain inhibition on regulating vascular inflammation and the underlying mechanisms. EXPERIMENTAL APPROACH: Human umbilical vein endothelial cells (HUVECs) were isolated from fresh umbilical cords...
October 24, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27754666/use-of-nutrient-rich-hydrophytes-to-create-n-p-dually-doped-porous-carbon-with-robust-energy-storage-performance
#13
Wu-Jun Liu, Ke Tian, Li-Li Ling, Han-Qing Yu, Hong Jiang
The optimal strategy for the safe disposal of large amounts of hydrophyte biomass with enriched levels of N and P is challenging. In this study, we proposed and illustrated a facile pyrolysis approach to prepare an N, P-dually doped porous carbon (NPC) material with robust energy storage performance using a thermochemical self-doping process and a widely distributed hydrophyte biomass (Typha angustifolia). As a supercapacitor electrode material for electrochemical energy storage, the NPC shows a maximum capacitance of 257 F g-1 and energy density of 19...
October 18, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27748806/ncym-is-upregulated-by-lncusmycn-and-modulates-n-myc-expression
#14
Pei Y Liu, Bernard Atmadibrata, Sujanna Mondal, Andrew E Tee, Tao Liu
Neuroblastoma is the most common solid tumor in early childhood. Patients with neuroblastoma due to the amplification of a 130-kb genomic DNA region containing the MYCN, MYCN antisense NCYM and lncUSMycN genes show poor prognosis. BET bromodomain inhibitors show anticancer efficacy against neuroblastoma partly by reducing MYCN gene transcription and N-Myc mRNA and protein expression. We have previously shown that the long nocoding RNA lncUSMycN upregulates N-Myc mRNA expression by binding to the RNA-binding protein NonO...
October 12, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27748776/titania-hollow-spheres-modified-with-tungstophosphoric-acid-with-enhanced-visible-light-absorption-for-the-photodegradation-of-4-chlorophenol
#15
M Á Orellana, L Osiglio, P M Arnal, L R Pizzio
Titania hollow spheres were synthesized using silica nanospheres as the template. The core was removed using NaOH solution. They were subsequently impregnated with tungstophosphoric acid (TPA) solutions and annealed at two different temperatures (100 and 500 °C). These materials were characterized by several physicochemical techniques (XRD, BET, SEM, DRS, FT-IR, FT-Raman and (31)P MAS-NMR). The (31)P MAS-NMR and FT-IR characterization showed that the main species present in the samples was the [PW12O40](3-) anion, which was partially transformed into the [P2W21O71](6-) anion during the synthesis and drying step...
October 17, 2016: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/27740661/an-ethylene-glycol-intercalated-monometallic-layered-double-hydroxide-based-on-iron-as-an-efficient-bifunctional-catalyst
#16
Rajamani Nagarajan, Pankaj Gupta, Poonam Singh, Pinki Chakraborty
Given the fact that the literature describing the intercalation of organic molecules in monometallic LDH systems is scarce, the present investigation is aimed at the generation of ethylene glycol intercalated Fe(II)-Fe(III) LDH with the objective of enhancing the surface area for further catalytic applications of industrially important and environmentally harmful organics. The solvothermal reaction of FeCl3 with urea in an ethylene glycol medium yielded a brown colored powder which was characterized employing a wide range of analytical techniques including high resolution powder X-ray diffraction (PXRD), scanning electron microscopy, thermal analysis, X-ray photo electron spectroscopy (XPS), elemental (C, H, N and S) analysis, UV-visible, photoluminescence spectroscopy measurements, BET surface area and pore-size analysis...
October 14, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27738693/in-situ-formation-of-nitrogen-doped-carbon-nanoparticles-on-hollow-carbon-spheres-as-efficient-oxygen-reduction-electrocatalysts
#17
Tingsheng Zhou, Yao Zhou, Ruguang Ma, Zhenzhen Zhou, Guanghui Liu, Qian Liu, Yufang Zhu, Jiacheng Wang
In situ formation of nitrogen-doped carbon nanoparticles on hollow carbon spheres (NHCSs) were successfully realised via a simple, scalable emulsion polymerization route using melamine as the nitrogen precursor, followed by thermal treatment at 1000 °C in N2. All NHCSs show large BET specific surface areas (648.2-837.7 cm(2) g(-1)) and pore volumes (0.91-1.16 cm(3) g(-1)), evidently superior to N-free hollow carbon spheres (HCSs) (524.3 cm(2) g(-1) and 0.48 cm(3) g(-1), respectively). This unique nanocomposite has hierarchical micro-/mesoporosity (1...
October 14, 2016: Nanoscale
https://www.readbyqxmd.com/read/27710838/bet-bromodomain-inhibition-reduces-maturation-and-enhances-tolerogenic-properties-of-human-and-mouse-dendritic-cells
#18
Ronald Schilderink, Matthew Bell, Eleonora Reginato, Chris Patten, Inmaculada Rioja, Francisca W Hilbers, Pawel A Kabala, Kris A Reedquist, David F Tough, Paul Peter Tak, Rab K Prinjha, Wouter J de Jonge
Transcription of inflammatory genes is tightly regulated by acetylation and deacetylation of histone tails. An inhibitor of the acetylated-lysine reader bromodomain and extra-terminal domain (BET) proteins, I-BET151, is known to counteract the induction of expression of inflammatory genes in macrophages. We have investigated the effects of I-BET151 on dendritic cell function, including expression of co-stimulatory molecules and cytokines, and capacity for T cell activation. Treatment of mouse bone marrow derived dendritic cells (BMDC) and human monocyte derived DCs (mdDC) with I-BET151 reduced LPS-induced expression of co-stimulatory molecules, as well as the production of multiple cyokines and chemokines...
October 3, 2016: Molecular Immunology
https://www.readbyqxmd.com/read/27704586/hypermethylation-of-prdm1-blimp-1-promoter-in-extranodal-nk-t-cell-lymphoma-nasal-type-an-evidence-of-predominant-role-in-its-downregulation
#19
Zhang Zhang, Li Liang, Dong Li, Lin Nong, Jumei Liu, Linlin Qu, Yalin Zheng, Bo Zhang, Ting Li
The loss of PRDM1 expression is common in extranodal NK/T-cell lymphoma, nasal type (EN-NK/T-NT), but the role of promoter methylation in silencing PRDM1 expression remains unclear. Hence, we performed pyrosequencing analysis to evaluate the promoter methylation of PRDM1 gene in vivo and in vitro, to analyze the association between methylation and its expression, and to assess cellular effects of PRDM1 reexpression. The promoter hypermethylation of PRDM1 gene was detected in 11 of 25 EN-NK/T-NT cases (44.0%) and NK92 and NKL cells...
October 5, 2016: Hematological Oncology
https://www.readbyqxmd.com/read/27690509/replicable-effects-of-primes-on-human-behavior
#20
B Keith Payne, Jazmin L Brown-Iannuzzi, Chris Loersch
[Correction Notice: An Erratum for this article was reported online in Journal of Experimental Psychology: General on Oct 31 2016 (see record 2016-52334-001). ] The effect of primes (i.e., incidental cues) on human behavior has become controversial. Early studies reported counterintuitive findings, suggesting that primes can shape a wide range of human behaviors. Recently, several studies failed to replicate some earlier priming results, raising doubts about the reliability of those effects. We present a within-subjects procedure for priming behavior, in which participants decide whether to bet or pass on each trial of a gambling game...
October 2016: Journal of Experimental Psychology. General
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