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urinary albumin

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https://www.readbyqxmd.com/read/28933781/relationship-between-subtle-urinary-albumin-excretion-and-risk-of-incident-hypertension-modification-by-glomerular-filtration-rate
#1
Masanori Munakata, Tomomi Hattori, Satoshi Konno
It has been reported that an increase in urinary albumin excretion (UAE) within the normal range could be a risk factor for incident hypertension. However, it remains unclear how the subtle increases in UAE and renal function interact in the development of hypertension. We examined the modification of UAE as a risk factor for incident hypertension by glomerular filtration rate (GFR) in the Japanese population. We prospectively followed 1281 normotensive individuals from Watari town (34.3% men; mean age, 58...
September 21, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28933159/hemoglobin-adducts-and-urinary-metabolites-of-arylamines-and-nitroarenes
#2
Gabriele Sabbioni
Arylamines and nitroarenes are intermediates in the production of pharmaceuticals, dyes, pesticides, and plastics and are important environmental and occupational pollutants. N-Hydroxyarylamines are the toxic common intermediates of arylamines and nitroarenes. N-Hydroxyarylamines and their derivatives can form adducts with hemoglobin (Hb-adducts), albumin, DNA, and tissue proteins in a dose-dependent manner. Most of the arylamine Hb-adducts are labile and undergo hydrolysis in vitro, by mild acid or base, to form the arylamines...
September 21, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28929659/-effects-and-mechanisms-of-shenkang-injection-promoting-extracellular-matrix-degradation-via-regulating-erk1-2-mmps-signaling-pathway-in-renal-failure-rats
#3
Jing-Jing Yang, Zhi-Min Mao, Yi-Gang Wan, Wei Wu, Yan-Ru Huang, Ge Shi, Wen-Bei Han, Jian Yao
This study aimed to clarify preliminarily the effects and mechanisms of Shenkang injection (SKI) promoting extracellular matrix(ECM)degradation via regulating extracellular-signal regulated protein kinase(ERK)1/2/matrix metalloproteinases(MMPs)signaling pathway in renal failure rats. Twenty rats were randomly divided into 4 groups:the Sham group,the Model group,the SKI group and the Enalapril maleate(EM)group. The model rats with renal failure were induced by intragastric administration of adenine and unilateral ureteral obstruction(UUO)...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28924138/perioperative-ketorolac-use-a-potential-risk-factor-for-renal-dysfunction-after-live-donor-nephrectomy
#4
Kazuhiro Takahashi, Anita K Patel, Shunji Nagai, Mohamed Safwan, Krishna G Putchakayala, William J Kane, Lauren E Malinzak, Jason E Denny, Atsushi Yoshida, Dean Y Kim
BACKGROUND Ketorolac is a nonsteroidal anti-inflammatory drug indicated for pain control after surgeries in many fields. The aim of this study was to evaluate the impact of ketorolac use after live-donor nephrectomy (LDN). MATERIAL AND METHODS We reviewed data on 251 patients who underwent laparoscopic LDN from April 2008 to March 2016. Ketorolac was given to 167 patients intraoperatively or postoperatively within 24 h after LDN. Glomerular filtration rate (GFR) percentage was defined as postoperative GFR/preoperative GFR...
September 19, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28919104/elevated-urinary-monocyte-chemoattractant-protein-1-levels-in-children-with-henoch-schonlein-purpura-nephritis
#5
Jiapei Wang, Qianqian Ying, Shiling Zhong, Yuanling Chen, Yazhen Di, Xiahua Dai, Jika Zheng, Mengjiao Shen
BACKGROUND: Chemokine monocyte chemoattractant protein-1 (MCP-1) has been proved as a potential urinary biomarker in nephropathies. The aim of this study was to investigate the urinary monocyte chemoattractant protein-1 (MCP-1) levels and clinical significance in Henoch-Schonlein purpura (HSP) children with and without nephritis and determine the association of MCP-1 with proteinuria. METHODS: A total of 261 HSP children-with or without nephritis-and 84 healthy control children were enrolled in this study...
August 26, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28916390/il-33-receptor-st2-deficiency-attenuates-renal-ischaemia-reperfusion-injury-in-euglycaemic-but-not-streptozotocin-induced-hyperglycaemic-mice
#6
M Sehnine, M Ferhat, S Sena, J M Gombert, J M Goujon, A Thierry, G Touchard, T Hauet, A Herbelin, S Hadjadj
AIM: Kidney hypoxia can predispose to the development of acute and chronic renal failure in diabetes. Ischaemia-reperfusion injury (IRI) causes inflammation, and diabetes is known to exacerbate this inflammatory response in the kidney, whereas alarmin IL-33 could act as an innate immune mediator during kidney IRI. Thus, the present study examined the impact of genetic IL-33 receptor ST2 deficiency (ST2-/-) on renal IRI in euglycaemic and hyperglycaemic mice. METHODS: Hyperglycaemia was induced with streptozotocin (STZ) in adult male C57BL/6JRj wild-type (WT) mice and ST2-/- mice...
September 12, 2017: Diabetes & Metabolism
https://www.readbyqxmd.com/read/28915229/the-optimal-night-time-home-blood-pressure-monitoring-schedule-agreement-with-ambulatory-blood-pressure-and-association-with-organ-damage
#7
Anastasios Kollias, Emmanuel Andreadis, Gerasimos Agaliotis, George N Kolyvas, Apostolos Achimastos, George S Stergiou
OBJECTIVE: Night-time home blood pressure (HBP) monitoring has emerged as a feasible, reliable and low-cost alternative to ambulatory blood pressure (ABP) monitoring. This study evaluated the optimal schedule of night-time HBP monitoring in terms of agreement with night-time ABP and association with preclinical target-organ damage. METHODS: Untreated hypertensive adults were evaluated with ABP (24-h) and HBP monitoring (daytime: six days, duplicate morning and evening measurements; night-time: three nights, three-hourly automated measurements/night), and determination of left ventricular mass index, common carotid intima-media thickness and urinary albumin excretion...
September 14, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28912839/addition-of-nonalbumin-proteinuria-to-albuminuria-improves-prediction-of-type-2-diabetic-nephropathy-progression
#8
Jong Ho Kim, Seo Young Oh, Eun Heui Kim, Min Jin Lee, Yun Kyung Jeon, Bo Hyun Kim, Jin Mi Kim, Yong Ki Kim, Sang Soo Kim, In Joo Kim
BACKGROUND: Albuminuria is generally accepted as a sensitive marker of diabetic nephropathy but has limitations in predicting its progression. The aim of this study was to evaluate the use of nonalbumin proteinuria in addition to albuminuria for predicting the progression of type 2 diabetic nephropathy. METHODS: In this retrospective observational study, the urine albumin-to-creatinine ratio (ACR) and the nonalbumin protein-to-creatinine ratio (NAPCR) were measured in 325 patients with type 2 diabetes and estimated glomerular filtration rates (eGFR) ≥30 mL/min/1...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28911025/home-blood-pressure-variability-from-the-stored-memory-is-correlated-with-albuminuria-but-from-the-logbook-is-not
#9
Shinobu Matsumoto, Emi Ushigome, Kanae Matsushita, Takuya Fukuda, Kazuteru Mitsuhashi, Saori Majima, Goji Hasegawa, Naoto Nakamura, Hidetaka Ushigome, Masahiro Yamazaki, Michiaki Fukui
BACKGROUND: The aim of this study was to evaluate whether the mean and the variability of home blood pressure (HBP) from the logbook correlate with albuminuria as well as HBP from the stored memory in patients with type 2 diabetes. METHODS: This study is a post hoc analysis of a cross-sectional multicenter study. HBP measurements were performed for 14 consecutive days in 276 patients with type 2 diabetes. Patients were requested to write down their HBP values in logbooks and were not informed about the memory function of their BP monitoring devices...
October 1, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28904298/usefulness-of-urinary-biomarkers-for-nephrotoxicity-in-cynomolgus-monkeys-treated-with-gentamicin-cisplatin-and-puromycin-aminonucleoside
#10
Hiroshi Uchino, Junko Fujishima, Kaori Fukuoka, Teppei Iwakiri, Akira Kamikuri, Hidenori Maeda, Kazuhiro Nakama
The objective of this study was to investigate the availability of novel urinary biomarkers (BMs) such as total protein, albumin, β2-microglobulin, clusterin, cystatin C, neutrophil gelatinase-associated lipocalin (NGAL) for the detection of acute nephrotoxicity in cynomolgus monkeys. Animals (total 9 males/3 groups) were administered gentamicin (GM) subcutaneously at 40 mg/kg for 7 days, cisplatin (CDDP) intravenously at 3 mg/kg once and puromycin aminonucleoside (PAN) intravenously at 20 mg/kg for 7 days...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28904068/empagliflozin-and-clinical-outcomes-in-patients-with-type-2-diabetes-established-cardiovascular-disease-and-chronic-kidney-disease
#11
Christoph Wanner, John M Lachin, Silvio E Inzucchi, David Fitchett, Michaela Mattheus, Jyothis T George, Hans-Juergen Woerle, Uli C Broedl, Maximilian von Eynatten, Bernard Zinman
Background -Empagliflozin, a sodium glucose cotransporter 2 inhibitor, reduced cardiovascular morbidity and mortality in patients with type 2 diabetes and established cardiovascular disease in the EMPA-REG OUTCOME(®) trial. Urinary glucose excretion with empagliflozin decreases with declining renal function, resulting in less potency for glucose lowering in patients with kidney disease. We investigated the effects of empagliflozin on clinical outcomes in patients with type 2 diabetes, established cardiovascular disease and chronic kidney disease...
September 13, 2017: Circulation
https://www.readbyqxmd.com/read/28901886/consumption-of-whole-grains-fruit-and-vegetables-is-not-associated-with-indices-of-renal-function-in-the-population-based-longitudinal-doetinchem-study
#12
Gerrie-Cor M Herber-Gast, Marijke Boersma, W M Monique Verschuren, Coen D A Stehouwer, Ron T Gansevoort, Stephan J L Bakker, Annemieke M W Spijkerman
Emerging evidence suggests that diet and renal function are related. Little is known, however, about the association of consumption of whole grains, fruit and vegetables with urinary albumin:creatinine ratio (ACR) and changes in estimated glomerular filtration rate (eGFR). We investigated this in a population-based cohort aged 26-65 years. Data were from 3787 participants from the Doetinchem cohort study, who were examined ≥3 times, 5 years apart. Consumption of food groups was assessed at each round with a validated FFQ...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28899432/prevalence-and-associations-of-microalbuminuria-in-proteinuria-negative-patients-with-type-2-diabetes-in-two-regional-hospitals-in-cameroon-a-cross-sectional-study
#13
Nelsy T Efundem, Jules Clement N Assob, Vitalis F Feteh, Simeon-Pierre Choukem
BACKGROUND: Microalbuminuria (MA) is the earliest clinical evidence of diabetic nephropathy, but most patients in sub-Saharan Africa (SSA) only have access to much cheaper dipstick proteinuria as a means to screen for diabetic nephropathy. The aim of this study was to determine the prevalence and associations of MA among proteinuria-negative type 2 diabetic patients in a SSA setting. METHODS: In this cross-sectional study, patients with type 2 diabetes screened negative for dipstick proteinuria in a primary healthcare hospital were assessed...
September 12, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28899425/the-physiological-determinants-of-low-level-urine-cadmium-an-assessment-in-a-cross-sectional-study-among-schoolchildren
#14
Hongyu Wang, Xavier Dumont, Vincent Haufroid, Alfred Bernard
BACKGROUND: Recent studies in children have reported associations of urinary cadmium (U-Cd), used as biomarker of Cd body burden, with renal dysfunction, retarded growth and impaired cognitive development in children. Little is known, however, about factors influencing U-Cd in children and likely to act as confounders. METHODS: In a cross-sectional study involving 249 schoolchildren (mean age, 5.72 years; 138 boys), we measured the urine concentrations of cadmium, zinc, lead, albumin, alpha1-microglobulin (A1M), retinol-binding protein, β2-microglobulin and club cell protein (CC16)...
September 12, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28894973/decreased-serum-extracellular-superoxide-dismutase-activity-is-associated-with-albuminuria-in-chinese-patients-with-type-2-diabetes-mellitus
#15
Gang Feng, Jia-Lin Gao, Peng Zhang, Jian-Jun Huang, Li-Zhu Huang, Long Cheng, Chun Pu
AIMS: The aim of this study was to determine the activity of serum extracellular superoxide dismutase (ecSOD) in patients with type 2 diabetes mellitus (T2DM) and healthy subjects, and to determine the prospective association between baseline serum ecSOD activity and the subsequent risk of albuminuria progression in a cohort of Chinese T2DM patients. METHODS: A total of 458 T2DM patients and 100 healthy subjects were assessed. After a median follow-up of 7.7 months, 319 patients with baseline normoalbuminuria (urinary albumin-to-creatinine ratio [UACR] <30 mg/g) and 77 patients with baseline microalbuminuria (UACR = 30-299 mg/g) were divided into progression and non-progression groups according to UACR changes...
September 12, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28890661/association-of-angiotensin-converting-enzyme-gene-polymorphisms-and-nephropathy-in-diabetic-patients-at-a-tertiary-care-centre-in-south-india
#16
Mukta Wyawahare, Revathy Neelamegam, Saranya Vilvanathan, R Soundravally, A K Das, C Adithan
BACKGROUND: Genetic polymorphisms of the angiotensin-renin pathway have been thought to influence the development of diabetic nephropathy. However, there are conflicting results regarding this association in previous studies on populations with varying ethnicity. AIMS: Primary aim was to compare the frequency of distribution of angiotensin-converting enzyme (ACE) gene (insertion/deletion [I/D]) polymorphism in Tamilian Indian type 2 diabetic individuals with and without microalbuminuria...
2017: Clinical Medicine Insights. Endocrinology and Diabetes
https://www.readbyqxmd.com/read/28886992/study-on-the-effect-of-irbesartan-on-atrial-fibrillation-recurrence-in-kumamoto-atrial-fibrillation-suppression-trial-silk-study
#17
Hiroshige Yamabe, Koichi Kaikita, Toshiyuki Matsumura, Atsushi Iwasa, Junjiro Koyama, Takashi Uemura, Yasuhiro Morikami, Ryusuke Tsunoda, Kenji Morihisa, Kazuteru Fujimoto, Ichiro Kajiwara, Kunihiko Matsui, Kenichi Tsujita, Hisao Ogawa
BACKGROUND: Experimental studies suggest that angiotensin II-receptor blockers can influence atrial remodeling and may prevent atrial fibrillation (AF). Therefore, we hypothesized that irbesartan may prevent the recurrence of AF following either catheter ablation or electrical cardioversion of AF. METHODS: Study on the Effect of Irbesartan on Atrial Fibrillation Recurrence in Kumamoto (SILK study) is a prospective, multicenter, randomized, and open-label comparative evaluation of the effects of irbesartan and amlodipine on AF recurrence in hypertensive patients with AF who are scheduled to undergo catheter ablation or electrical cardioversion of AF...
September 5, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28878300/white-coat-and-masked-hypertension-are-associated-with-albuminuria-in-a-general-population-the-hisayama-study
#18
Jun Hata, Masayo Fukuhara, Satoko Sakata, Hisatomi Arima, Yoichiro Hirakawa, Koji Yonemoto, Naoko Mukai, Takanari Kitazono, Yutaka Kiyohara, Toshiharu Ninomiya
Epidemiological and clinical studies have investigated the influence of hypertension on chronic kidney disease (CKD), but limited data are available for the associations of white-coat hypertension (WCHT), masked hypertension (MHT) and sustained hypertension (SHT) with kidney dysfunction in general populations. We examined the associations of these types of hypertension with CKD (albuminuria and reduction in estimated glomerular filtration rate (eGFR)) in a cross-sectional survey of 2974 community-dwelling Japanese aged ⩾40 years...
September 7, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28875008/renal-hemosiderosis-among-iranian-transfusion-dependent-%C3%AE-thalassemia-major-patients
#19
Mozhgan Hashemieh, Mitra Radfar, Azita Azarkeivan, Seyed Mohammad Taghi Hosseini Tabatabaei, Sedigheh Nikbakht, Mehdi Yaseri, Kourosh Sheibani
Background: In recent years, the success in management of thalassemic patients, has allowed for some previously unrecognized complications including renal abnormalities to emerge. This prospective study aimed to investigate kidney iron overload by means of MRI T2* and also renal function based on laboratory tests for early markers of glomerular and tubular dysfunction among adult Iranian transfusion-dependent thalassemia major patients. Subjects and Methods: Two-hundred and two patients with transfusion-dependent β-thalassemia major were included in this study in Zafar Adult Thalassemia Center, Tehran, Iran...
April 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28874181/effect-of-an-intensive-nutrition-intervention-of-a-high-protein-and-low-glycemic-index-diet-on-weight-of-kidney-transplant-recipients-study-protocol-for-a-randomized-clinical-trial
#20
Elis Forcellini Pedrollo, Bruna Bellincanta Nicoletto, Larissa Salomoni Carpes, Júlia de Melo Cardoso de Freitas, Julia Roberta Buboltz, Cristina Carra Forte, Andrea Carla Bauer, Roberto Ceratti Manfro, Gabriela Corrêa Souza, Cristiane Bauermann Leitão
BACKGROUND: Excessive weight gain is commonly observed within the first year after kidney transplantation and is associated with negative outcomes, such as graft loss and cardiovascular events. The purpose of this study is to evaluate the effect of a high protein and low glycemic-index diet on preventing weight gain after kidney transplantation. METHODS: We designed a prospective, single-center, open-label, randomized controlled study to compare the efficacy of a high protein (1...
September 6, 2017: Trials
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