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crpc hepatic involvement

William K Oh, Matthew D Galsky, Walter M Stadler, Sandy Srinivas, Franklin Chu, Glenn Bubley, J Goddard, Joi Dunbar, Robert W Ross
OBJECTIVE: To evaluate clinical activity and safety of retaspimycin hydrochloride (IPI-504) in patients with castration-resistant prostate cancer (CRPC). METHODS: A single-arm trial was conducted in 2 cohorts: group 1, chemotherapy naive; group 2, docetaxel-treated. IPI-504 was administered intravenously at 400 mg/m2 on days 1, 4, 8, and 11 of a 21-day cycle. Trial expansion was planned if ≥1 prostate-specific antigen (PSA) or radiographic response was noted per cohort...
September 2011: Urology
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