Adelina Lombrea, Claudia Geanina Watz, Larisa Bora, Cristina Adriana Dehelean, Zorita Diaconeasa, Stefania Dinu, Māris Turks, Jevgeņija Lugiņina, Uldis Peipiņš, Corina Danciu
The prevalence and severity of skin cancer, specifically malignant melanoma, among Caucasians remains a significant concern. Natural compounds from plants have long been explored as potential anticancer agents. Betulinic acid (BI) has shown promise in its therapeutic properties, including its anticancer effects. However, its limited bioavailability has hindered its medicinal applications. To address this issue, two recently synthesized semisynthetic derivatives, N -(2,3-indolo-betulinoyl)diglycylglycine (BA1) and N -(2,3-indolo-betulinoyl)glycylglycine (BA2), were compared with previously reported compounds N -(2,3-indolo-betulinoyl)glycine (BA3), 2,3-indolo-betulinic acid (BA4), and BI...
December 21, 2023: Plants (Basel, Switzerland)