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Melanoma natural compound

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https://www.readbyqxmd.com/read/28485554/identification-of-aca-28-a-1-acetoxychavicol-acetate-analogue-compound-as-a-novel-modulator-of-erk-mapk-signaling-which-preferentially-kills-human-melanoma-cells
#1
Ryosuke Satoh, Kanako Hagihara, Kazuki Matsuura, Yoshiaki Manse, Ayako Kita, Tatsuki Kunoh, Takashi Masuko, Mariko Moriyama, Hiroyuki Moriyama, Genzoh Tanabe, Osamu Muraoka, Reiko Sugiura
The extracellular signal-regulated kinase (ERK) signaling pathway is essential for cell proliferation and is frequently deregulated in human tumors such as melanoma. Melanoma remains incurable despite the use of conventional chemotherapy; consequently, development of new therapeutic agents for melanoma is highly desirable. Here, we carried out a chemical genetic screen using a fission yeast phenotypic assay and showed that ACA-28, a synthetic derivative of 1'-acetoxychavicol acetate (ACA), which is a natural ginger compound, effectively inhibited the growth of melanoma cancer cells wherein ERK MAPK signaling is hyperactivated due to mutations in the upstream activating regulators...
May 9, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28481901/%C3%AE-lapachone-suppresses-the-lung-metastasis-of-melanoma-via-the-mapk-signaling-pathway
#2
Ji-Ye Kee, Yo-Han Han, Dae-Seung Kim, Jeong-Geon Mun, Seong-Hwan Park, Hong-Seob So, Sung-Joo Park, Raekil Park, Jae-Young Um, Seung-Heon Hong
β-Lapachone is a natural quinone compound from Lapacho trees, which has various pharmacological effects such as anti-bacterial, anti-fungal, anti-viral, and anti-inflammatory activities. However, the effect of β-lapachone on metastasis of melanoma cells is unclear. In this study, β-lapachone reduced cell viability of metastatic melanoma cancer cell lines B16F10 and B16BL6 through induction of apoptosis via the mitogen-activated protein kinase (MAPK) pathway. Additionally, flow cytometry results showed that β-lapachone increased DNA content in the G0/G1 phase of the cell cycle...
2017: PloS One
https://www.readbyqxmd.com/read/28456625/effects-of-matsutake-mushroom-scent-compounds-on-tyrosinase-and-murine-b16-f10-melanoma-cells
#3
Hiroki Satooka, Philip Cerda, Hae-Jung Kim, William F Wood, Isao Kubo
Tyrosinase-catalyzed l-tyrosine oxidation is a key step in melanogenesis, and intense melanin formation is often a problem in chemotherapies or food preservation. Here we report that methyl cinnamate one of the constituents characterized from mycelium and sporocarp of American matsutake mushroom Tricholoma magnivelare inhibits both enzymatic and cellular melanin formation. Methyl cinnamate inhibits mushroom tyrosinase-catalyzed l-tyrosine oxidation while the oxidation of l-3,4-dihydroxyphenylalanine (l-DOPA) was not inhibited...
June 10, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28399449/synthesis-and-biological-evaluation-of-neoglycosphingolipids
#4
Shuihong Cheng, Peixing Wu, Jing Han, Yiren Wang, Yuting Cui, Zhenxing Zhang, Tatsuya Yamagata, Xuebing Li
Various neoglycosphingolipids were efficiently synthesized in a one-step reaction by the coupling of free sugars with an N-alkylaminooxy-functionalized ceramide analogue. The bioactivity studies demonstrated that most of these compounds could upregulate the expression of matrix metalloproteinase-9 (MMP-9, extracellular matrix proteins associated with tumor migration) in murine melanoma B16 cells in a similar manner to the natural ganglioside monosialodihexosylganglioside (GM3), which highlights the potential use of these neoglycosphingolipids as inhibitors of tumor migration...
April 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28395361/terpenoids-from-leaves-of-guarea-macrophylla-display-in-vitro-cytotoxic-activity-and-induce-apoptosis-in-melanoma-cells
#5
Geanne Alexandra A Conserva, Natalia Girola, Carlos R Figueiredo, Ricardo A Azevedo, Sasha Mousdell, Patricia Sartorelli, Marisi G Soares, Guilherme M Antar, João Henrique G Lago
Guarea macrophylla is a Brazilian plant species that has been used in folk medicine to treat a range of diseases. Our ongoing work focuses on the discovery of new bioactive natural products derived from Brazilian flora. The current study describes the identification of cytotoxic compounds from the EtOH extract of leaves from G. macrophylla using bioactivity-guided fractionation. This approach resulted in the isolation and characterization of four compounds: cycloart-23E-ene-3β,25-diol (1), (23S*,24S*)-dihydroxycicloart-25-en-3-one (2), isopimara-7,15-diene-2α,3β-diol (3), and isopimara-7,15-dien-3β-ol (4), in which 2 and 3 are identified as new derivatives...
April 10, 2017: Planta Medica
https://www.readbyqxmd.com/read/28373669/garcinol-loaded-vitamin-e-tpgs-emulsified-plga-nanoparticles-preparation-physicochemical-characterization-in-vitro-and-in-vivo-studies
#6
Raghuvir H Gaonkar, Soumya Ganguly, Saikat Dewanjee, Samarendu Sinha, Amit Gupta, Shantanu Ganguly, Dipankar Chattopadhyay, Mita Chatterjee Debnath
Garcinol (GAR) is a naturally occurring polyisoprenylated phenolic compound. It has been recently investigated for its biological activities such as antioxidant, anti-inflammatory, anti ulcer, and antiproliferative effect on a wide range of human cancer cell lines. Though the outcomes are very promising, its extreme insolubility in water remains the main obstacle for its clinical application. Herein we report the formulation of GAR entrapped PLGA nanoparticles by nanoprecipitation method using vitamin E TPGS as an emulsifier...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28351318/cytotoxicity-of-citral-against-melanoma-cells-the-involvement-of-oxidative-stress-generation-and-cell-growth-protein-reduction
#7
Larissa Juliani Sanches, Poliana Camila Marinello, Carolina Panis, Tatiane Renata Fagundes, José Andrés Morgado-Díaz, Julio Cesar Madureira de-Freitas-Junior, Rubens Cecchini, Alessandra Lourenço Cecchini, Rodrigo Cabral Luiz
Citral is a natural compound that has shown cytotoxic and antiproliferative effects on breast and hematopoietic cancer cells; however, there are few studies on melanoma cells. Oxidative stress is known to be involved in all stages of melanoma development and is able to modulate intracellular pathways related to cellular proliferation and death. In this study, we hypothesize that citral exerts its cytotoxic effect on melanoma cells by the modulation of cellular oxidative status and/or intracellular signaling...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28333105/anti-melanogenic-properties-of-greek-plants-a-novel-depigmenting-agent-from-morus-alba-wood
#8
Eliza Chaita, George Lambrinidis, Christina Cheimonidi, Adamantia Agalou, Dimitris Beis, Ioannis Trougakos, Emmanuel Mikros, Alexios-Leandros Skaltsounis, Nektarios Aligiannis
In therapeutic interventions associated with melanin hyperpigmentation, tyrosinase is regarded as a target enzyme as it catalyzes the rate-limiting steps in mammalian melanogenesis. Since many known agents have been proven to be toxic, there has been increasing impetus to identify alternative tyrosinase inhibitors, especially from natural sources. In this study, we investigated 900 extracts from Greek plants for potential tyrosinase inhibitive properties. Among the five most potent extracts, the methanol extract of Morus alba wood (MAM) demonstrated a significant reduction in intracellular tyrosinase and melanin content in B16F10 melanoma cells...
March 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28300789/anti-cancer-activity-of-resveratrol-and-derivatives-produced-by-grapevine-cell-suspensions-in-a-14-l-stirred-bioreactor
#9
Laetitia Nivelle, Jane Hubert, Eric Courot, Philippe Jeandet, Aziz Aziz, Jean-Marc Nuzillard, Jean-Hugues Renault, Christophe Clément, Laurent Martiny, Dominique Delmas, Michel Tarpin
In the present study, resveratrol and various oligomeric derivatives were obtained from a 14 L bioreactor culture of elicited grapevine cell suspensions (Vitis labrusca L.). The crude ethyl acetate stilbene extract obtained from the culture medium was fractionated by centrifugal partition chromatography (CPC) using a gradient elution method and the major stilbenes contained in the fractions were subsequently identified by using a (13)C-NMR-based dereplication procedure and further 2D NMR analyses including HSQC, HMBC, and COSY...
March 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28287317/chemosensitizing-effect-of-saikosaponin-b-on-b16f10-melanoma-cells
#10
Heyao Ma, Satoru Yokoyama, Ikuo Saiki, Yoshihiro Hayakawa
Cancer cell resistance to chemotherapy is one of the obstacles for better cancer treatment, and inflammatory signaling pathways, such as NF-κB signaling pathway, have been recognized to be involved in such chemoresistance. In this study, we aim to identify a new approach for overcoming cancer chemoresistance by using natural compounds. As a result of screening by using Murine B16F10 melanoma cell line constitutively expressing NF-κB luciferase reporter gene, we identified Saikosaponin B2 as an effective inhibitor for etoposide-induced NF-κB activation in B16F10NFkB cells...
April 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28286420/hlbt-100-a-highly-potent-anti-cancer-flavanone-from-tillandsia-recurvata-l-l
#11
Henry I C Lowe, Ngeh J Toyang, Charah T Watson, Kenneth N Ayeah, Joseph Bryant
BACKGROUND: The incidence and mortalities from cancers remain on the rise worldwide. Despite significant efforts to discover and develop novel anticancer agents, many cancers remain in the unmet need category. As such, efforts to discover and develop new and more effective and less toxic agents against cancer remain a top global priority. Our drug discovery approach is natural products based with a focus on plants. Tillandsia recurvata (L.) L. is one of the plants selected by our research team for further studies based on previous bioactivity findings on the anticancer activity of this plant...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28283753/cosmetic-applications-of-glucitol-core-containing-gallotannins-from-a-proprietary-phenolic-enriched-red-maple-acer-rubrum-leaves-extract-inhibition-of-melanogenesis-via-down-regulation-of-tyrosinase-and-melanogenic-gene-expression-in-b16f10-melanoma-cells
#12
Hang Ma, Jialin Xu, Nicholas A DaSilva, Ling Wang, Zhengxi Wei, Liangran Guo, Shelby L Johnson, Wei Lu, Jun Xu, Qiong Gu, Navindra P Seeram
The red maple (Acer rubrum) is a rich source of phenolic compounds which possess galloyl groups attached to different positions of a 1,5-anhydro-D-glucitol core. While these glucitol-core containing gallotannins (GCGs) have reported anti-oxidant and anti-glycative effects, they have not yet been evaluated for their cosmetic applications. Herein, the anti-tyrosinase and anti-melanogenic effects of a proprietary phenolic-enriched red maple leaves extract [Maplifa(™); contains ca. 45% ginnalin A (GA) along with other GCGs] were investigated using enzyme and cellular assays...
May 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28278663/melanogenesis-inhibitors-from-coix-lacryma-jobi-seeds-in-b16-f10-melanoma-cells
#13
Yhiya Amen, Enos Tangke Arung, Mohamed S Afifi, Ahmed F Halim, Ahmed Ashour, Ryoji Fujimoto, Takahiro Goto, Kuniyoshi Shimizu
An adenine derivative, 9-β-D-glucopyranosyl adenine, reported for the first time from a natural source, in addition to nine known compounds were isolated from the seeds of Coix lacryma-jobi. Their structures were elucidated based on extensive spectroscopic and chemical studies. The isolated compounds and the ethanol extract have been assayed for melanin inhibition using B16-F10 melanoma cell line. The results of our study suggested the potential use of Coix lacryma-jobi seeds as a skin whitening agent and reveal the seeds to be a rich source of important phytochemicals with melanogenesis inhibitory activity...
February 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28260881/ginseng-berry-mediated-gold-and-silver-nanoparticle-synthesis-and-evaluation-of-their-in-vitro-antioxidant-antimicrobial-and-cytotoxicity-effects-on-human-dermal-fibroblast-and-murine-melanoma-skin-cell-lines
#14
Zuly Elizabeth Jiménez Pérez, Ramya Mathiyalagan, Josua Markus, Yeon-Ju Kim, Hyun Mi Kang, Ragavendran Abbai, Kwang Hoon Seo, Dandan Wang, Veronika Soshnikova, Deok Chun Yang
There has been a growing interest in the design of environmentally affable and biocompatible nanoparticles among scientists to find novel and safe biomaterials. Panax ginseng Meyer berries have unique phytochemical profile and exhibit beneficial pharmacological activities such as antihyperglycemic, antiobesity, antiaging, and antioxidant properties. A comprehensive study of the biologically active compounds in ginseng berry extract (GBE) and the ability of ginseng berry (GB) as novel material for the biosynthesis of gold nanoparticles (GBAuNPs) and silver nanoparticles (GBAgNPs) was conducted...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28238718/towards-therapeutic-advances-in-melanoma-management-an-overview
#15
REVIEW
Swarnendra Singh, Atif Zafar, Saman Khan, Imrana Naseem
Melanoma is one of the most aggressive types of skin cancer with rapidly increasing incidence rate. The disease is largely considered incurable and the patients diagnosed with metastatic melanoma have a survival of not more than five years. Despite of the recent advances in anti-melanoma chemo- and immunotherapies, the available drugs are relatively toxic and responsive to only a limited subset of lesions. Currently, topical pharmacotherapy is demonstrated as an effective approach for the treatment of various skin cancers...
April 1, 2017: Life Sciences
https://www.readbyqxmd.com/read/28167449/curcumin-and-treatment-of-melanoma-the-potential-role-of-micrornas
#16
REVIEW
Diana Lelli, Claudio Pedone, Amirhosssein Sahebkar
Melanoma is the most aggressive type of skin cancer and is characterized by poor prognosis in its advanced stages because treatments are poorly effective and burdened with severe adverse effects. MicroRNAs (miRNAs) are small non-coding RNAs that are implicated in several cellular processes; they are categorized as oncogenic and tumor suppressor miRNAs. Several miRNAs are implicated in the pathogenesis and progression of melanoma, such as the tumor suppressor miR-let7b that targets cyclin D and regulates cell cycle...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28148715/the-exportin-1-inhibitor-selinexor-exerts-superior-antitumor-activity-when-combined-with-t-cell-checkpoint-inhibitors
#17
Matthew R Farren, Rebecca C Hennessey, Reena Shakya, Omar Elnaggar, Gregory Young, Kari Kendra, Yosef Landesman, Sivan Elloul, Marsha Crochiere, Boris Klebanov, Trinayan Kashyap, Christin E Burd, Gregory B Lesinski
Selinexor, a selective inhibitor of nuclear export (SINE) compound targeting exportin-1, has previously been shown to inhibit melanoma cell growth in vivo We hypothesized that combining selinexor with antibodies that block or disrupt T-cell checkpoint molecule signaling would exert superior antimelanoma activity. In vitro, selinexor increased PDCD1 and CTLA4 gene expression in leukocytes and induced CD274 gene expression in human melanoma cell lines. Mice bearing syngeneic B16F10 melanoma tumors demonstrated a significant reduction in tumor growth rate in response to the combination of selinexor and anti-PD-1 or anti-PD-L1 antibodies (P < 0...
March 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28131904/potential-therapeutic-targets-of-epithelial-mesenchymal-transition-in-melanoma
#18
Ross L Pearlman, Mary Katherine Montes de Oca, Harish Chandra Pal, Farrukh Afaq
Melanoma is a cutaneous neoplastic growth of melanocytes with great potential to invade and metastasize, especially when not treated early and effectively. Epithelial-mesenchymal transition (EMT) is the process by which melanocytes lose their epithelial characteristics and acquire mesenchymal phenotypes. Mesenchymal protein expression increases the motility, invasiveness, and metastatic potential of melanoma. Many pathways play a role in promotion of mesenchymal protein expression including RAS/RAF/MEK/ERK, PI3K/AKT/mTOR, Wnt/β-catenin, and several others...
April 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28092677/wnt-%C3%AE-catenin-signaling-regulates-mitochondrial-activity-to-alter-the-oncogenic-potential-of-melanoma-in-a-pten-dependent-manner
#19
K Brown, P Yang, D Salvador, R Kulikauskas, H Ruohola-Baker, A M Robitaille, A J Chien, R T Moon, V Sherwood
Aberrant regulation of WNT/β-catenin signaling has a crucial role in the onset and progression of cancers, where the effects are not always predictable depending on tumor context. In melanoma, for example, models of the disease predict differing effects of the WNT/β-catenin pathway on metastatic progression. Understanding the processes that underpin the highly context-dependent nature of WNT/β-catenin signaling in tumors is essential to achieve maximal therapeutic benefit from WNT inhibitory compounds. In this study, we have found that expression of the tumor suppressor, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), alters the invasive potential of melanoma cells in response to WNT/β-catenin signaling, correlating with differing metabolic profiles...
January 16, 2017: Oncogene
https://www.readbyqxmd.com/read/28060735/the-natural-compound-fucoidan-from-new-zealand-undaria-pinnatifida-synergizes-with-the-erbb-inhibitor-lapatinib-enhancing-melanoma-growth-inhibition
#20
Varsha Thakur, Jun Lu, Giuseppe Roscilli, Luigi Aurisicchio, Manuela Cappelletti, Emiliano Pavoni, William Lindsey White, Barbara Bedogni
Melanoma remains one of the most aggressive and therapy-resistant cancers. Finding new treatments to improve patient outcomes is an ongoing effort. We previously demonstrated that melanoma relies on the activation of ERBB signaling, specifically of the ERBB3/ERBB2 cascade. Here we show that melanoma tumor growth is inhibited by 60% over controls when treated with lapatinib, a clinically approved inhibitor of ERBB2/EGFR. Importantly, tumor growth is further inhibited to 85% when the natural compound fucoidan from New Zealand U...
March 14, 2017: Oncotarget
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