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Melanoma natural compound

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https://www.readbyqxmd.com/read/28060735/the-natural-compound-fucoidan-from-new-zealand-undaria-pinnatifida-synergizes-with-the-erbb-inhibitor-lapatinib-enhancing-melanoma-growth-inhibition
#1
Varsha Thakur, Jun Lu, Giuseppe Roscilli, Luigi Aurisicchio, Manuela Cappelletti, Emiliano Pavoni, William Lindsey White, Barbara Bedogni
Melanoma remains one of the most aggressive and therapy-resistant cancers. Finding new treatments to improve patient outcomes is an ongoing effort. We previously demonstrated that melanoma relies on the activation of ERBB signaling, specifically of the ERBB3/ERBB2 cascade. Here we show that melanoma tumor growth is inhibited by 60% over controls when treated with lapatinib, a clinically approved inhibitor of ERBB2/EGFR. Importantly, tumor growth is further inhibited to 85% when the natural compound fucoidan from New Zealand U...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28053599/anticancer-properties-of-ester-derivatives-of-betulin-in-human-metastatic-melanoma-cells-me-45
#2
Małgorzata Drąg-Zalesińska, Marcin Drąg, Marcin Poręba, Sylwia Borska, Julita Kulbacka, Jolanta Saczko
BACKGROUND: Betulinic acid and betulin are triterpenes that have anticancer properties in various types of cancer. Unfortunately, the bioavailability and the bio-distribution of betulinic acid and its metabolic precursor, betulin are very low because of poor solubility in aqueous buffers. METHODS: In this study, we examined the anticancer properties of the ester derivatives of betulin compared to their precursors in a malignant melanoma cell line. We assessed five amino acid esters of betulin...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28051915/alisol-b-a-triterpene-from-alismatis-rhizoma-dried-rhizome-of-alisma-orientale-inhibits-melanin-production-in-murine-b16-melanoma-cells
#3
Ichiro Yoshida, Chihiro Ito, Shinya Matsuda, Akihiko Tsuji, Noriyuki Yanaka, Keizo Yuasa
To develop new whitening agents from natural products, we screened 80 compounds derived from crude drugs in Kampo medicine in a melanin synthesis inhibition assay using murine B16 melanoma cells. The screen revealed that treatment with alisol B, a triterpene from Alismatis rhizoma, significantly decreased both melanin content and cellular tyrosinase activity in B16 cells. However, alisol B did not directly inhibit mushroom tyrosinase activity in vitro. Therefore, we investigated the mechanism underlying the inhibitory effect of alisol B on melanogenesis...
January 4, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28035958/a-multifunctional-and-possible-skin-uv-protectant-3r-5-hydroxymellein-produced-by-an-endolichenic-fungus-isolated-from-parmotrema-austrosinense
#4
Lu Zhao, Jin-Cheol Kim, Man-Jeong Paik, Wonjae Lee, Jae-Seoun Hur
Lichens are considered a great bio-resource because they produce large numbers of secondary metabolites with many biological activities; however, they have not been cultivated under artificial conditions to date. As a result, lichen substances from natural sources are limited and have not been widely utilized in commercial applications. Accordingly, interest in lichen-associated fungi, especially endogenic fungi, has increased. Ultraviolet (UV) radiation in sunlight is harmful to human health, resulting in demand for effective UV filtering agents for use in sunscreen...
December 26, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27979631/indole-3-carbinol-i3c-analogues-are-potent-small-molecule-inhibitors-of-nedd4-1-ubiquitin-ligase-activity-that-disrupt-proliferation-of-human-melanoma-cells
#5
Jeanne G Quirit, Sergey N Lavrenov, Kevin Poindexter, Janice Xu, Christine Kyauk, Kathleen A Durkin, Ida Aronchik, Thomas Tomasiak, Yaroslav A Solomatin, Maria N Preobrazhenskaya, Gary L Firestone
The HECT domain-containing E3 ubiquitin ligase NEDD4-1 (Neural precursor cell Expressed Developmentally Down regulated gene 4-1) is frequently overexpressed in human cancers and displays oncogenic-like properties through the ubiquitin-dependent regulation of multiple protein substrates. However, little is known about small molecule enzymatic inhibitors of HECT domain-containing ubiquitin ligases. We now demonstrate that indole-3-carbinol (I3C), a natural anti-cancer phytochemical derived from cruciferous vegetables such as cabbage and broccoli, represents a new chemical scaffold of small molecule enzymatic inhibitors of NEDD4-1...
December 12, 2016: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27978787/synthesis-and-antiproliferative-activity-of-new-pyrazolo-3-4-c-pyridines
#6
Efthymios-Spyridon Gavriil, Nikolaos Lougiakis, Nicole Pouli, Panagiotis Marakos, Alexios-Leandros Skaltsounis, Sangkil Nam, Richard Jove, David Horne, Katerina Gioti, Harris Pratsinis, Dimitris Kletsas, Roxane Tenta
BACKGROUND: Several pyrazolopyridines possess promising pharmacological activities, mainly attributed to their antagonistic nature towards the natural purines in many biological processes. Cytotoxicity and anticancer potential of this class of compounds is mainly related to induction of apoptotic cell death and inhibition of protein kinases. OBJECTIVES: This prompted us to design, synthesize and study the antiproliferative activity of a number of new 3,7-disubstituted pyrazolo[3,4-c] pyridines...
December 13, 2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27833586/estrogen-receptor-%C3%AE-in-melanoma-from-molecular-insights-to-potential-clinical-utility
#7
REVIEW
Monica Marzagalli, Marina Montagnani Marelli, Lavinia Casati, Fabrizio Fontana, Roberta Manuela Moretti, Patrizia Limonta
Cutaneous melanoma is an aggressive tumor; its incidence has been reported to increase fast in the past decades. Melanoma is a heterogeneous tumor, with most patients harboring mutations in the BRAF or NRAS oncogenes, leading to the overactivation of the MAPK/ERK and PI3K/Akt pathways. The current therapeutic approaches are based on therapies targeting mutated BRAF and the downstream pathway, and on monoclonal antibodies against the immune checkpoint blockade. However, treatment resistance and side effects are common events of these therapeutic strategies...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27826190/biogenesis-of-silver-nanoparticles-using-endophytic-fungus-pestalotiopsis-microspora-and-evaluation-of-their-antioxidant-and-anticancer-activities
#8
Vasudeva Reddy Netala, Murali Satyanarayana Bethu, Bobbu Pushpalatha, Vijaya Bhaskar Baki, Sani Aishwarya, J Venkateswara Rao, Vijaya Tartte
An endophytic fungal strain isolated from the leaves of Gymnema sylvestre was identified as Pestalotiopsis microspora VJ1/VS1 based on nucleotide sequencing of internal transcribed spacer region (ITS 1-5.8S-ITS 2) of 18S rRNA gene (NCBI accession number KX213894). In this study, an efficient and ecofriendly approach has been reported for the synthesis of silver nanoparticles (AgNPs) using aqueous culture filtrate of P. microspora. Ultraviolet-visible analysis confirmed the synthesis of AgNPs by showing characteristic absorption peak at 435 nm...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27756508/melanogenesis-inhibitory-activity-of-a-7-o-9-linked-neolignan-from-alpinia-galanga-fruit
#9
Yoshiaki Manse, Kiyofumi Ninomiya, Ryosuke Nishi, Iyori Kamei, Yushi Katsuyama, Takahito Imagawa, Saowanee Chaipech, Osamu Muraoka, Toshio Morikawa
An aqueous acetone extract from the fruit of Alpinia galanga (Zingiberaceae) demonstrated inhibitory effects on melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells (IC50=7.3μg/mL). Through bioassay-guided separation of the extract, a new 7-O-9'-linked neolignan, named galanganol D diacetate (1), was isolated along with 16 known compounds including 14 phenylpropanoids (2-15). The structure of 1, including its absolute stereochemistry in the C-7 position, was elucidated by means of extensive NMR analysis and total synthesis...
October 6, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27721049/jasmine-rice-panicle-a-safe-and-efficient-natural-ingredient-for-skin-aging-treatments
#10
Mayuree Kanlayavattanakul, Nattaya Lourith, Puxvadee Chaikul
ETHNOPHARMACOLOGICAL RELEVANCE: While rice is one of the most important global staple food sources its extracts have found many uses as the bases of herbal remedies. Rice extracts contain high levels of phenolic compounds which are known to be bioactive, some of which show cutaneous benefits and activity towards skin disorders. This study highlights an assessment of the cellular activity and clinical efficacy of rice panicle extract, providing necessary information relevant to the development of new cosmetic products...
December 4, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27718421/dna-damage-protecting-and-free-radical-scavenging-properties-of-mycosporine-2-glycine-from-the-dead-sea-cyanobacterium-in-a375-human-melanoma-cell-lines
#11
Vipaporn Cheewinthamrongrod, Hakuto Kageyama, Tanapat Palaga, Teruhiro Takabe, Rungaroon Waditee-Sirisattha
Mycosporine-like amino acids (MAAs) are a group of natural sunscreen compounds that possess highly photoprotective properties. The most commonly found MAAs in marine organisms is shinorine, porphyra-334, and mycosporine-glycine. However, the halophilic species accumulate mycosporine-2-glycine (M2G) as the major MAA. In this study, we have investigated the protective effect of M2G against oxidative stress. In vitro radical scavenging activity revealed that M2G exhibited a significant inhibition with scavenging concentration (SC) 50 value of 22±1...
November 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27697511/liposomal-systems-as-viable-drug-delivery-technology-for-skin-cancer-sites-with-an-outlook-on-lipid-based-delivery-vehicles-and-diagnostic-imaging-inputs-for-skin-conditions
#12
REVIEW
Naseem Akhtar, Riaz A Khan
Skin cancer is among one of the most common human malignancies wide-spread world-over with mortality statistics rising continuously at an alarming rate. The increasing frequency of these malignancies has marked the need for adopting effective treatment plan coupled with better and site-specific delivery options for the desired therapeutic agent's availability at the affected site. The concurrent delivery approaches to cancerous tissues are under constant challenge and, as a result, are evolving and gaining advancements in terms of delivery modes, therapeutic agents and site-specificity of the therapeutics delivery...
September 30, 2016: Progress in Lipid Research
https://www.readbyqxmd.com/read/27671820/honokiol-an-active-compound-of-magnolia-plant-inhibits-growth-and-progression-of-cancers-of-different-organs
#13
Ram Prasad, Santosh K Katiyar
Honokiol (C18H18O2) is a biphenolic natural product isolated from the bark and leaves of Magnolia plant spp. During the last decade or more, honokiol has been extensively studied for its beneficial effect against several diseases. Investigations have demonstrated that honokiol possesses anti-carcinogenic, anti-inflammatory, anti-oxidative, anti-angiogenic as well as inhibitory effect on malignant transformation of papillomas to carcinomas in vitro and in vivo animal models without any appreciable toxicity. Honokiol affects multiple signaling pathways, molecular and cellular targets including nuclear factor-κB (NF-κB), STAT3, epidermal growth factor receptor (EGFR), cell survival signaling, cell cycle, cyclooxygenase and other inflammatory mediators, etc...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27671038/melanoma-and-obesity-should-antioxidant-vitamins-be-addressed
#14
REVIEW
Sofia Oliveira, Pedro Coelho, Cristina Prudêncio, Mónica Vieira, Raquel Soares, Susana G Guerreiro, Rúben Fernandes
Melanoma is an aggressive form of skin cancer refractory to conventional therapies. Obesity has reached epidemic dimensions acting as a risk factor for several cancer types, such as melanoma. Several reactive species of oxygen are also involved in melanoma initiation and progression. Low levels of antioxidant content and/or activity in lightly pigmented cells could expose them to an extremely oxidative environment and rise the susceptibility to oxidative damage and consequently loss of cell homeostasis. Despite the knowledge about melanoma biology, pathogenesis and developed therapies, is extremely important to understand the antioxidant modulation of melanoma under an environment of obesity, especially the effect of some natural compounds of the diet, such as antioxidant vitamins A, C and E and selenium in order to establish alternatives to conventional therapies, which are known to be ineffective against melanoma...
November 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27650755/natural-products-from-aquatic-eukaryotic-microorganisms-for-cancer-therapy-perspectives-on-anti-tumour-properties-of-ciliate-bioactive-molecules
#15
Elisabetta Catalani, Francesca Proietti Serafini, Silvia Zecchini, Simona Picchietti, Anna Maria Fausto, Enrico Marcantoni, Federico Buonanno, Claudio Ortenzi, Cristiana Perrotta, Davide Cervia
Several modern drugs, including those for cancer therapy, have been isolated from natural sources, are based on natural products and its derivatives, or mime natural products. Some of them are in clinical use, others in clinical trials. The success of natural products in drug discovery is related to their biochemical characteristics and to the technologic methods used to study their feature. Natural compounds may acts as chemo-preventive agents and as factors that increase therapeutic efficacy of existing drugs, thus overcoming cancer cell drug resistance that is the main factor determining the failure in conventional chemotherapy...
September 17, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27639645/berberine-suppressed-epithelial-mesenchymal-transition-through-cross-talk-regulation-of-pi3k-akt-and-rar%C3%AE-rar%C3%AE-in-melanoma-cells
#16
Yu Kou, Lei Li, Hong Li, Yuhui Tan, Bin Li, Kun Wang, Biaoyan Du
Berberine is a natural compound extracted from Coptidis rhizoma, and accumulating proof has shown its potent anti-tumor properties with diverse action on melanoma cells, including inhibiting cancer viability, blocking cell cycle and migration. However, the mechanisms of berberine have not been fully clarified. In this study, we identified that berberine reduced the migration and invasion capacities of B16 cells, and notably altered pluripotency of epithelial to mesenchymal transition associated factors. We found that berberine also downregulation the expression level of p-PI3K, p-AKT and retinoic acid receptor α (RARα) and upregulation the expression level of retinoic acid receptor β and γ (RARβ and RARγ)...
October 14, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27613608/transient-receptor-potential-cation-3-channel-regulates-melanoma-proliferation-and-migration
#17
Kayoko Oda, Masanari Umemura, Rina Nakakaji, Ryo Tanaka, Itaru Sato, Akane Nagasako, Chiaki Oyamada, Erdene Baljinnyam, Mayumi Katsumata, Lai-Hua Xie, Masatoshi Narikawa, Yukie Yamaguchi, Taisuke Akimoto, Makoto Ohtake, Takayuki Fujita, Utako Yokoyama, Kousaku Iwatsubo, Michiko Aihara, Yoshihiro Ishikawa
Melanoma has an extremely poor prognosis due to its rapidly progressive and highly metastatic nature. Several therapeutic drugs have recently become available, but are effective only against melanoma with specific BRAF gene mutation. Thus, there is a need to identify other target molecules. We show here that Transient receptor potential, canonical 3 (TRPC3) is widely expressed in human melanoma. We found that pharmacological inhibition of TRPC3 with a pyrazole compound, Pyr3, decreased melanoma cell proliferation and migration...
September 9, 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27571057/betulin-phosphonates-synthesis-structure-and-cytotoxic-activity
#18
Elwira Chrobak, Ewa Bębenek, Monika Kadela-Tomanek, Małgorzata Latocha, Christian Jelsch, Emmanuel Wenger, Stanisław Boryczka
Betulin derivatives are a widely studied group of compounds of natural origin due to their wide spectrum of biological activities. This paper describes new betulin derivatives, containing a phosphonate group. The allyl-vinyl isomerization and synthesis of acetylenic derivatives have been reported. Structural identification of products as E and Z isomers has been carried out using ¹H-, (13)C-, (31)P-NMR, and crystallographic analysis. The crystal structure in the orthorhombic space group and analysis of crystal packing contacts for 29-diethoxyphosphoryl-28-cyclopropylpropynoyloxy-lup-20E(29)-en-3β-ol 8a are reported...
August 26, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27563423/the-cytotoxicity-of-dacarbazine-potentiated-by-sea-cucumber-saponin-in-resistant-b16f10-melanoma-cells-through-apoptosis-induction
#19
Javad Baharara, Elaheh Amini, Najme Nikdel, Farzaneh Salek-Abdollahi
BACKGROUND: Malignant melanoma is a highly aggressive malignant melanocytic neoplasm which resists against the most conventional therapies. Sea cucumber as one of marine organisms contains bioactive compounds such as polysaccharide, terpenoid and other metabolites which have anti-cancer, anti-tumor, anti-inflammatory and antioxidant properties. The present study was designed to investigate the anticancer potential of saponin extracted from sea cucumber Holothuria leucospilata alone and in combination with dacarbazine on B16F10 melanoma cell line...
July 2016: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/27502897/inhibition-of-autophagy-enhances-curcumin-united-light-irradiation-induced-oxidative-stress-and-tumor-growth-suppression-in-human-melanoma-cells
#20
Tianhui Niu, Yan Tian, Zhusong Mei, Guangjin Guo
Malignant melanoma is the most aggressive form of skin carcinoma, which possesses fast propagating and highly invasive characteristics. Curcumin is a natural phenol compound that has various biological activities, such as anti-proliferative and apoptosis-accelerating impacts on tumor cells. Unfortunately, the therapeutical activities of Cur are severely hindered due to its extremely low bioavailability. In this study, a cooperative therapy of low concentration Cur combined with red united blue light irradiation was performed to inspect the synergistic effects on the apoptosis, proliferation and autophagy in human melanoma A375 cell...
2016: Scientific Reports
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