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https://www.readbyqxmd.com/read/29770521/nicotine-mediated-neuroprotection-of-rat-spinal-networks-against-excitotoxicity
#1
Jaspreet Kaur, Rossana Rauti, Andrea Nistri
Activation of neuronal nicotinic acetylcholine receptors (nAChRs) by nicotine is reported to protect brain neurons from glutamate excitotoxicity. We inquired whether a similar phenomenon can occur in the rat isolated spinal cord (or spinal slice culture) challenged by a transient (1 h) application of kainate (a powerful glutamate receptor agonist) to induce excitotoxicity mimicking spinal injury in vitro. We recorded spinal reflexes and fictive locomotion generated by the locomotor central pattern generator before and 24 h after applying kainate...
May 16, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29765265/is-volumetric-modulated-arc-therapy-with-constant-dose-rate-a-valid-option-in-radiation-therapy-for-head-and-neck-cancer-patients
#2
Annamaria Didona, Valentina Lancellotta, Claudio Zucchetti, Bianca Moira Panizza, Alessandro Frattegiani, Martina Iacco, Anna Concetta Di Pilato, Simonetta Saldi, Cynthia Aristei
Background: Intensity-modulated radiotherapy (IMRT) improves dose distribution in head and neck (HN) radiation therapy. Volumetric-modulated arc therapy (VMAT), a new form of IMRT, delivers radiation in single or multiple arcs, varying dose rates (VDR-VMAT) and gantry speeds, has gained considerable attention. Constant dose rate VMAT (CDR-VMAT) associated with a fixed gantry speed does not require a dedicated linear accelerator like VDR-VMAT. The present study explored the feasibility, efficiency and delivery accuracy of CDR-VMAT, by comparing it with IMRT and VDR-VMAT in treatment planning for HN cancer...
May 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29761987/-comparison-of-planning-quality-and-delivery-efficiency-between-volumetric-modulated-arc-therapy-and-dynamic-intensity-modulated-radiation-therapy-for-nasopharyngeal-carcinoma-with-more-than-4-prescribed-dose-levels
#3
Pengfei Jia, Jun Xu, Xiaoxi Zhou, Jian Chen, Lemin Tang
The aim of this study is to compare the planning quality and delivery efficiency between dynamic intensity modulated radiation therapy (d-IMRT) and dual arc volumetric modulated arc therapy (VMAT) systematically for nasopharyngeal carcinoma (NPC) patients with multi-prescribed dose levels, and to analyze the correlations between target volumes and plan qualities. A total of 20 patients of NPC with 4-5 prescribed dose levels to achieve simultaneous integrated boost (SIB) treated by sliding window d-IMRT in our department from 2014 to 2015 were re-planned with dual arc VMAT...
December 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29753078/isolated-pediatric-intramedullary-schwannoma-case-report-and-review-of-the-literature
#4
Alessandro Landi, Giovanni Grasso, Fabrizio Gregori, Giorgia Iacopino, Andrea Ruggeri, Roberto Delfini
BACKGROUND: Intramedullary (IM) schwannomas are rare entities representing the 0.3-1% of intramedullary tumors and 1.1% of spinal schwannomas. Beside many theories proposed, their rare occurrence might be related to the absence of Schwann cells into the spinal cord. Pediatric IM schwannomas are uncommon and in absence of neurofibromatosis (NF) they are extremely rare. To date, very few cases have been reported in the literature. CASE DESCRIPTION: We describe the case of a 8 year-old female affected by a progressive paraparesis...
May 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29729461/high-risk-surgical-maneuvers-for-impending-true-positive-intraoperative-neurologic-monitoring-alerts-experience-in-3139-consecutive-spine-surgeries
#5
Shujie Wang, Qiyi Li, Jie Zhu, Jianxiong Shen, Ye Tian, Yong Hu, Jianguo Zhang
BACKGROUND: Intraoperative neurologic monitoring (IONM) has become an essential component for decreasing the incidence of spinal cord injury during many spine surgeries. Many high-risk surgical maneuvers that result in significant IONM alerts have not been reported systematically. Our objective in this study was to thoroughly summarize some common high-risk surgical points associated with IONM alerts in various spine surgeries. METHODS: A total of 62 patients with true-positive IONM alerts from 3139 spine surgeries were enrolled between November 2010 and April 2017...
May 2, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29715704/benefits-and-risks-of-prophylactic-cerebrospinal-fluid-catheter-and-evoked-potential-monitoring-in-symptomatic-spinal-cord-ischemia-low-risk-thoracic-endovascular-aortic-repair
#6
Sven Maier, Maria Shcherbakova, Friedhelm Beyersdorf, Christoph Benk, Fabian Alexander Kari, Matthias Siepe, Martin Czerny, Bartosz Rylski
BACKGROUND:  To assess risks and benefits of a standardized strategy to prevent symptomatic spinal cord ischemia (SSCI) after thoracic endovascular repair (TEVAR) using routine cerebrospinal fluid (CSF) catheter placement and evoked potential (EP) monitoring. METHODS:  One hundred and ninety-five patients underwent 223 SSCI low-risk TEVAR procedures between 1998 and 2014. CSF catheter was used to measure CSF pressure and drain CSF if necessary throughout the procedure and up to 24 hours thereafter...
May 1, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29700477/lower-extremity-outcome-measures-considerations-for-clinical-trials-in-spinal-cord-injury
#7
REVIEW
Marc Bolliger, Andrew R Blight, Edelle C Field-Fote, Kristin Musselman, Serge Rossignol, Dorothy Barthélemy, Laurent Bouyer, Milos R Popovic, Jan M Schwab, Michael L Boninger, Keith E Tansey, Giorgio Scivoletto, Naomi Kleitman, Linda A T Jones, Dany H Gagnon, Sylvie Nadeau, Dirk Haupt, Lea Awai, Chris S Easthope, Björn Zörner, Ruediger Rupp, Dan Lammertse, Armin Curt, John Steeves
STUDY DESIGN: This is a focused review article. OBJECTIVES: To identify important concepts in lower extremity (LE) assessment with a focus on locomotor outcomes and provide guidance on how existing outcome measurement tools may be best used to assess experimental therapies in spinal cord injury (SCI). The emphasis lies on LE outcomes in individuals with complete and incomplete SCI in Phase II-III trials. METHODS: This review includes a summary of topics discussed during a workshop focusing on LE function in SCI, conceptual discussion of corresponding outcome measures and additional focused literature review...
April 27, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29689005/perioperative-complications-after-surgery-for-thoracic-ossification-of-posterior-longitudinal-ligament-nationwide-multicenter-prospective-study
#8
Shiro Imagama, Kei Ando, Kazuhiro Takeuchi, Satoshi Kato, Hideki Murakami, Toshimi Aizawa, Hiroshi Ozawa, Tomohiko Hasegawa, Yukihiro Matsuyama, Masao Koda, Masashi Yamazaki, Hirotaka Chikuda, Shigeo Shindo, Yukihiro Nakagawa, Atsushi Kimura, Katsushi Takeshita, Kanichiro Wada, Hiroyuki Katoh, Masahiko Watanabe, Kei Yamada, Takeo Furuya, Takashi Tsuji, Shunsuke Fujibayashi, Kanji Mori, Yoshiharu Kawaguchi, Kota Watanabe, Morio Matsumoto, Toshitaka Yoshii, Atsushi Okawa
STUDY DESIGN: Prospective, multicenter, nationwide study OBJECTIVE.: To investigate perioperative complications and risk factors in surgery for thoracic ossification of the posterior longitudinal ligament (T-OPLL) using data from the registry of the Japanese Multicenter Research Organization for Ossification of the Spinal Ligament. SUMMARY OF BACKGROUND DATA: There is no prospective multicenter study of surgical complications and risk factors for T-OPLL, and previous multicenter retrospective studies have lacked details...
April 23, 2018: Spine
https://www.readbyqxmd.com/read/29688505/letter-guidelines-for-the-use-of-electrophysiological-monitoring-for-surgery-of-the-human-spinal-column-and-spinal-cord
#9
Marshall Wilkinson, David Houlden
No abstract text is available yet for this article.
April 24, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29688447/in-reply-guidelines-for-the-use-of-electrophysiological-monitoring-for-surgery-of-the-human-spinal-column-and-spinal-cord
#10
Mark N Hadley, Christopher D Shank, Curtis J Rozzelle, Beverly C Walters
No abstract text is available yet for this article.
April 24, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29687146/genistein-modulates-the-expression-of-toll-like-receptors-in-experimental-autoimmune-encephalomyelitis
#11
Alyria Teixeira Dias, Sandra Bertelli Ribeiro de Castro, Caio César de Souza Alves, Marcilene Gomes Evangelista, Luan Cristian da Silva, Daniele Ribeiro de Lima Reis, Marco Antonio Machado, Maria Aparecida Juliano, Ana Paula Ferreira
OBJECTIVE AND DESIGN: The present work investigates the modulation of experimental autoimmune encephalomyelitis (EAE) using genistein before the EAE induction. MATERIAL: Female C57BL/6 mice (n = 96 mice/experiment), 4-6 weeks old, were used to induce the EAE. The mice were divided into three experimental groups: non-immunized group, immunized group (EAE), and immunized and treated with genistein group (Genistein). TREATMENT: Genistein was used at a dose of 200 mg/kg s...
April 23, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29686917/a-recurrent-cervical-neurenteric-cyst-treated-anteriorly-safe-gross-total-excision-facilitated-by-prophylactic-unilateral-vertebral-artery-exposure-microdissection-and-spinal-cord-monitoring-a-case-report-and-technical-note
#12
Kazunobu Kida, Toshikazu Tani, Tateo Kawazoe, Makoto Hiroi
This study reports on a 67-year-old woman with partial Brown-Séquard syndrome due to a recurrent cervical neurenteric cyst at C3 to C4. The myelopathic symptoms reappeared 22 years after a previous shunting operation performed posteriorly with a silicone tube connecting the intradural cervical cyst cavity to the subarachnoid space. We have now succeeded in removing the cyst nearly completely with the anterior approach. The surgical procedure consisted of right vertebral artery exposure at C3 and C4 and a subtotal corpectomy of C3 followed by microdissection of the cyst, duraplasty, and iliac strut graft fusion...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29685166/automated-vmat-planning-for-postoperative-adjuvant-treatment-of-advanced-gastric-cancer
#13
Abdul Wahab M Sharfo, Florian Stieler, Oskar Kupfer, Ben J M Heijmen, Maarten L P Dirkx, Sebastiaan Breedveld, Frederik Wenz, Frank Lohr, Judit Boda-Heggemann, Daniel Buergy
BACKGROUND: Postoperative/adjuvant radiotherapy of advanced gastric cancer involves a large planning target volume (PTV) with multi-concave shapes which presents a challenge for volumetric modulated arc therapy (VMAT) planning. This study investigates the advantages of automated VMAT planning for this site compared to manual VMAT planning by expert planners. METHODS: For 20 gastric cancer patients in the postoperative/adjuvant setting, dual-arc VMAT plans were generated using fully automated multi-criterial treatment planning (autoVMAT), and compared to manually generated VMAT plans (manVMAT)...
April 23, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29683363/cardiovascular-autonomic-response-to-orthostatic-stress-under-hypoxia-in-patients-with-spinal-cord-injury
#14
Shu-Chun Huang, Kuo-Cheng Liu, Alice M K Wong, Shih-Chieh Chang, Jong-Shyan Wang
Huang, Shu-Chun, Kuo-Cheng Liu, Alice M.K. Wong, Shih-Chieh Chang, and Jong-Shyan Wang. Cardiovascular autonomic response to orthostatic stress under hypoxia in patients with spinal cord injury. High Alt Med Biol. 00:000-000, 2018. AIMS: Determining whether systemic hypoxia aggravates the severity of autonomic cardiovascular dysfunction in orthostatic stress among patients with spinal cord injuries (SCIs). METHODS: Twenty-four male patients with chronic SCI whose neurological levels were above T6 were recruited...
April 23, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29679165/future-brain-and-spinal-cord-volumetric-imaging-in-the-clinic-for-monitoring-treatment-response-in-ms
#15
REVIEW
Tim Sinnecker, Cristina Granziera, Jens Wuerfel, Regina Schlaeger
PURPOSE OF REVIEW: Volumetric analysis of brain imaging has emerged as a standard approach used in clinical research, e.g., in the field of multiple sclerosis (MS), but its application in individual disease course monitoring is still hampered by biological and technical limitations. This review summarizes novel developments in volumetric imaging on the road towards clinical application to eventually monitor treatment response in patients with MS. RECENT FINDINGS: In addition to the assessment of whole-brain volume changes, recent work was focused on the volumetry of specific compartments and substructures of the central nervous system (CNS) in MS...
April 20, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29669805/glucocorticoid-induced-diabetes-in-patients-with-metastatic-spinal-cord-compression
#16
Helga Holm Schultz, Svend Aage Engelholm, Eva Harder Brix, Ulrik Pedersen-Bjergaard, Peter Lommer Kristensen
BACKGROUND: The risk of developing diabetes mellitus (DM) during treatment with high dose glucocorticoids is unknown and monitoring of glucose is random in many settings. OBJECTIVE: To determine incidence of and risk factors for induction of DM during high dose glucocorticoid therapy of metastatic spinal cord compression in patients referred to radiotherapy. Furthermore, to describe the time course of development of DM. SUBJECTS AND METHODS: 140 patients were recruited (131 were included in the analysis) with metastatic spinal cord compression receiving high dose glucocorticoid, ≥100 mg prednisolone per day were included in a prospective, observational cohort study...
April 18, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29664964/monitoring-for-myelopathic-progression-with-multiparametric-quantitative-mri
#17
Allan R Martin, Benjamin De Leener, Julien Cohen-Adad, Sukhvinder Kalsi-Ryan, David W Cadotte, Jefferson R Wilson, Lindsay Tetreault, Aria Nouri, Adrian Crawley, David J Mikulis, Howard Ginsberg, Eric M Massicotte, Michael G Fehlings
BACKGROUND: Patients with mild degenerative cervical myelopathy (DCM) are often managed non-operatively, and surgery is recommended if neurological progression occurs. However, detection of progression is often subjective. Quantitative MRI (qMRI) directly measures spinal cord (SC) tissue changes, detecting axonal injury, demyelination, and atrophy. This longitudinal study compared multiparametric qMRI with clinical measures of progression in non-operative DCM patients. METHODS: 26 DCM patients were followed...
2018: PloS One
https://www.readbyqxmd.com/read/29664238/testing-of-a-new-portable-device-for-dynamic-bladder-pressure-monitoring
#18
Lingfeng Liu, Kang Zhao, Fan Chen, Jian Wu, Zhaofeng Yang, Ming Chen, Linbo Mao, Jiurong Han
OBJECTIVE: To develop a portable dynamic bladder pressure monitoring device for facilitating the monitoring of bladder detrusor pressure in patients with neurogenic bladder (NB) caused by spinal cord injury and further compared the effect with traditional urodynamics devices. METHODS: Portable dynamic bladder pressure monitoring device was implemented by software and hardware. The hardware was mainly composed of seven parts, such as micro liquid pressure sensor, electric bridge amplifying circuit, clock module, SD card storage circuit, liquid crystal display circuit, touch circuit, controller circuit and so on...
May 2018: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/29662203/potent-antitumor-efficacy-of-anti-gd2-car-t-cells-in-h3-k27m-diffuse-midline-gliomas
#19
Christopher W Mount, Robbie G Majzner, Shree Sundaresh, Evan P Arnold, Meena Kadapakkam, Samuel Haile, Louai Labanieh, Esther Hulleman, Pamelyn J Woo, Skyler P Rietberg, Hannes Vogel, Michelle Monje, Crystal L Mackall
Diffuse intrinsic pontine glioma (DIPG) and other diffuse midline gliomas (DMGs) with mutated histone H3 K27M (H3-K27M)1-5 are aggressive and universally fatal pediatric brain cancers 6 . Chimeric antigen receptor (CAR)-expressing T cells have mediated impressive clinical activity in B cell malignancies7-10 , and recent results suggest benefit in central nervous system malignancies11-13 . Here, we report that patient-derived H3-K27M-mutant glioma cell cultures exhibit uniform, high expression of the disialoganglioside GD2...
April 16, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29656621/effect-of-myoarchitectonic-spinolaminoplasty-on-concurrent-hypertension-in-patients-with-cervical-spondylotic-myelopathy
#20
Kazushige Itoki, Ryu Kurokawa, Tetsuro Shingo, Phyo Kim
OBJECTIVE: When treating patients with cervical spondylotic myelopathy (CSM), we often note amelioration in concomitant hypertension after surgery. To assess the effects of surgery and the mechanisms thereof, blood pressure (BP) and parasympathetic nervous activity were monitored prospectively in CSM patients undergoing surgery. METHODS: Sixty-eight consecutive CSM patients who underwent surgery with myoarchitectonic spinolaminoplasty were enrolled. BP and electrocardiography were recorded preoperatively and at 1, 3, and 6 months postoperatively...
March 2018: Neurospine
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