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https://www.readbyqxmd.com/read/28749549/a-double-blind-placebo-controlled-study-of-rituximab-in-patients-with-stiff-person-syndrome
#1
Marinos C Dalakas, Goran Rakocevic, James M Dambrosia, Harry Alexopoulos, Beverly McElroy
Objective In Stiff-Person Syndrome (SPS), an antibody-mediated impaired GABAergic neurotransmission is believed to cause muscle stiffness and spasms. Patients improve with GABA-enhancing drugs and IVIg, but several respond poorly and remain disabled. The need for more effective therapy prompted a trial with the anti-CD20 monoclonal antibody rituximab. Methods This was a placebo-controlled randomized trial of rituximab (two bi-weekly infusions of 1gr each). The primary outcome was a change in stiffness scores at 6 months...
July 27, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28749176/quantifying-potential-reduction-in-contrast-dose-with-monoenergetic-images-synthesized-from-duallayer-detector-spectral-ct
#2
Derek S Tsang, Thomas E Merchant, Sophie E Merchant, Hanna Smith, Yoad Yagil, Chia-Ho Hua
OBJECTIVES: To estimate the potential dose reduction in iodinated contrast when interpreting monoenergetic images from spectral CT. METHODS: 51 pediatric patients received contrast-enhanced CT simulation for radiation therapy using a single-source, dual-layer detector spectral CT. The contrast-to-noise ratios (CNR) of blood vessels were measured relative to surrounding soft tissue. CNRs on monoenergetic 40-70 keV images were compared with polychromatic 120 kVp images...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28748165/triple-antithrombotic-therapy-in-patients-undergoing-percutaneous-coronary-intervention-balancing-between-ischemia-and-bleeding
#3
Konstantinos C Koskinas, Lorenz Räber
No abstract text is available yet for this article.
June 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28746215/s-1-monotherapy-versus-s-1-combination-therapy-in-gemcitabine-refractory-advanced-pancreatic-cancer-a-meta-analysis-prisma-of-randomized-control-trials
#4
Sheng Zhong, Shuai Qie, Liu Yang, Qi Yan, Linna Ge, Zhongfeng Wang
BACKGROUND: Pancreatic cancer (PC) is one of the most lethal digestive system tumors. Most new cases are diagnosed based on metastasis or local aggression and are known as "advanced PC." Recently, studies investigating S-1 have indicated that it has a better clinical curative effect on PC. We conducted a meta-analysis to evaluate the efficacy and safety of S-1 monotherapy compared with S-1 combination regimens in patients with gemcitabine (GEM)-refractory PC. METHODS: Trials published between 1978 and 2016 were identified by an electronic search of public databases (Medline, Embase, and the Cochrane Library)...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28744752/radiotherapy-for-ductal-carcinoma-in-situ-and-risk-of-second-non-breast-cancers
#5
Diana R Withrow, Lindsay M Morton, Rochelle E Curtis, Sara J Schonfeld, Amy Berrington de González
PURPOSE: Radiotherapy for ductal carcinoma (DCIS) is increasing, but the risks and benefits of the treatment remain uncertain. We aimed to investigate the relationship between radiotherapy for DCIS and risk of second non-breast cancers in a large US cohort. METHODS: We conducted a retrospective cohort study of 52,556 women in 12 U.S. population-based cancer registries diagnosed with first primary DCIS during 1992-2008 at age 25-79 years. We estimated relative risks (RRs), attributable risks (AR), and excess absolute risks (EAR) of second non-breast cancers associated with radiotherapy using Poisson regression adjusted for age at year of diagnosis, grade, hormonal therapy (yes/no or unknown), and time since diagnosis...
July 25, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28744049/the-effects-of-task-oriented-training-with-altered-sensory-input-on-balance-in-patients-with-chronic-stroke
#6
Min-Hee Park, Jong-Im Won
[Purpose] The purpose of this study was to identify the effects of task-oriented training with altered somatosensory input on the balance ability of chronic stroke patients. [Subjects and Methods] Twenty-six subjects with chronic stroke were divided into an experimental group (n=14) and a control group (n=12). Both groups attended physical therapy sessions five times a week for four weeks. The experimental group performed additional, task-oriented training with altered sensory input three times a week for four weeks...
July 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28744037/effects-of-pedalo-%C3%A2-training-on-balance-and-fall-risk-in-stroke-patients
#7
Do-Yeon Kim, Chae-Gil Lim
[Purpose] This study sought to examine the effects of Pedalo(®) training on balance and fall risk in stroke patients. [Subjects and Methods] Thirty-one subjects with stroke were recruited and randomly allocated into two groups: the Pedalo(®) group (n=15) and the Treadmill group (n=16). The Pedalo(®) group performed conventional physical therapy program with Pedalo(®) training for 30 minutes, five times a week, for 8 weeks, while the Treadmill group conducted conventional physical therapy programs and treadmill gait training for 30 minutes, five times a week, for 8 weeks...
July 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28744036/interrelationship-between-postural-balance-and-body-posture-in-children-and-adolescents
#8
Oliver Ludwig
[Purpose] This study examined possible interrelationships between postural sway and posture parameters in children and adolescents with a particular focus on posture weakness. [Subjects and Methods] 308 healthy children and adolescents (124 girls, 184 boys, aged 12.3 ± 2.5 years) participated in the study. Posture parameters (posture index, head protrusion, trunk inclination) were determined based on posture photos in the sagittal plane. Postural sway was measured during 20 seconds on a force plate. The Pearson's product-moment correlation coefficients between the anthropometric and posture parameters and the sway path length (SPL) were calculated, as well as the coefficient of determination R(2)...
July 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28744033/the-effect-of-cognitive-motor-dual-task-training-with-the-biorescue-force-platform-on-cognition-balance-and-dual-task-performance-in-institutionalized-older-adults-a-randomized-controlled-trial
#9
Tom Delbroek, Wietse Vermeylen, Joke Spildooren
[Purpose] This study investigates whether cognition, balance and dual task performance in institutionalized older adults improves by a virtual reality dual task training. [Subjects and Methods] Randomized controlled trial; Twenty institutionalized older adults with mild cognitive impairment (13 female, 7 male; average age, 87.2 ± 5.96 years) were randomized to the intervention (i.e. Virtual reality dual-task training using the BioRescue) or control group (no additional training). The intervention group took part in a 6-week training program while the elderly in the control group maintained their daily activities...
July 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28741493/derisking-drug-induced-carcinogenicity-for-novel-therapeutics
#10
REVIEW
Jonathan G Moggs, Timothy MacLachlan, Hans-Joerg Martus, Philip Bentley
Assessing the carcinogenic potential of innovative drugs spanning diverse therapeutic modalities and target biology represents a major challenge during drug development. Novel modalities, such as cell and gene therapies that involve intrinsic genetic modification of the host genome, require distinct approaches for identification of cancer hazard. We emphasize the need for customized weight-of-evidence cancer risk assessments based on mode of action that balance multiple options for preclinical identification of cancer hazard with appropriate labeling of clinical products and risk management plans...
August 2016: Trends in Cancer
https://www.readbyqxmd.com/read/28741166/a-new-key-player-in-vegf-dependent-angiogenesis-in-human-hepatocellular-carcinoma-dimethylarginine-dimethylaminohydrolase-1
#11
Nikki Buijs, J Efraim Oosterink, Morgan Jessup, Henk Schierbeek, Donna B Stolz, Alexander P Houdijk, David A Geller, Paul A van Leeuwen
BACKGROUND: Anti-angiogenic therapies, targeting VEGF, are a promising treatment for hepatocellular carcinoma (HCC). To enhance this potential therapy, identification of novel targets in this pathway is of major interest. Nitric oxide (NO) plays a crucial role in VEGF-dependent angiogenesis. NO production depends on arginine as substrate and asymmetric dimethylarginine (ADMA) as inhibitor. Dimethylarginine dimethylaminohydrolase 1 (DDAH-1) catabolizes ADMA and therefore regulates NO and VEGF expression...
July 24, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28740348/comparison-of-short-and-long-term-outcomes-of-laparoscopic-vs-open-resection-for-gastric-gastrointestinal-stromal-tumors
#12
Xin Ye, Wei-Ming Kang, Jian-Chun Yu, Zhi-Qiang Ma, Zhi-Gang Xue
AIM: To compare the short- and long-term outcomes of laparoscopic (LR) vs open resection (OR) for gastric gastrointestinal stromal tumors (gGISTs). METHODS: In total, 301 consecutive patients undergoing LR or OR for pathologically confirmed gGISTs from 2005 to 2014 were enrolled in this retrospective study. After exclusion of 77 patients, 224 eligible patients were enrolled (122 undergoing LR and 102 undergoing OR). The demographic, clinicopathologic, and survival data of all patients were collected...
July 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28739765/relationship-of-th17-treg-cells-and-radiation-pneumonia-in-locally-advanced-esophageal-carcinoma
#13
Yan Wang, Gang Xu, Jie Wang, Xin-Hua Li, Ping Sun, Wei Zhang, Jun-Xia Li, Chao-Yang Wu
BACKGROUND/AIM: Radiation pneumonia is a main side-effect that has limited the clinical usage of radiotherapy in locally advanced esophageal carcinoma. T helper cells 17 (Th 17) and T regulatory cells (Tregs) play an important role in inflammatory diseases. The balance between Treg and Th17 cells is a key factor in the progression of many inflammatory and autoimmune diseases. Whether Tregs and Th17 cells are predictive factors of radiation pneumonia has not yet been reported. In this study, we investigated the relationships of Treg/Th17 cells and radiation pneumonia in patients with locally advanced esophageal cancer who received radiotherapy...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739555/serum-nesfatin-1-levels-in-girls-with-idiopathic-central-precocious-puberty
#14
Ayça Altıncık, Oya Sayın
OBJECTIVE: Nesfatin-1, which is defined as an anorexigenic neuropeptide, is expressed mainly in central nervous system and in some periferic tissues. The role of nesfatin-1 in energy balance has been investigated; however, data are limited on the role of nesfatin-1 in human puberty. METHODS: The aim of this study was to investigate the following: i) the role of nesfatin-1 in puberty; and ii) relationship between nesfatin-1 and anthropometric measures, gonadotropin levels in girls with idiopathic central precocious puberty (CPP)...
July 24, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28739551/the-description-of-a-new-case-with-proopiomelanocortin-pomc-deficiency-an-increasingly-important-diagnosis-to-make
#15
Semra Çetinkaya, Tülay Güran, Erdal Kurnaz, Melikşah Keskin, Elif Sağsak, Senay Savaş Erdeve, Jenifer P Suntharalingham, Federica Buonocore, John Achermann, Zehra Aycan
International surveillance data suggests a worldwide epidemic of pediatric obesity regardless of geographic, socioeconomic, racial and ethnic factors. Reversing this epidemic of pediatric obesity will require recognition and understanding of the pathophysiology of the condition to enable us to develop novel therapies as well as taking measures to shift social attitudes and public policies at a global level. Proopiomelanocortin (POMC) deficiency is a rare monogenic disorder of early-onset obesity, which has increased our insight into the important role of the leptin-melanocortin pathway in energy balance...
July 24, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28739199/results-of-the-first-american-prospective-study-of-intravenous-iron-in-oral-iron-intolerant-iron-deficient-gravidas
#16
Michael Auerbach, Stephanie E James, Melissa Nicoletti, Steven Lenowitz, Nicola London, Huzefa F Bahrain, Richard Derman, Samuel Smith
BACKGROUND: Anemia affects up to 42% of gravidas. Neonatal iron deficiency is associated with low birth weight, delayed growth and development, and increased cognitive and behavioral abnormalities. While oral iron is convenient, up to 70% report significant gastrointestinal toxicity. Intravenous iron formulations allowing replacement in one visit with favorable side-effect profiles decrease rates of anemia with improved hemoglobin responses and maternal fetal outcomes. METHODS: 74 oral iron intolerant, 2(nd) and 3(rd) trimester iron deficient gravidas were questioned for oral iron intolerance and treated with intravenous iron...
July 21, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28739098/effects-of-bariatric-surgery-on-energy-homeostasis
#17
REVIEW
Wei Li, Denis Richard
Bariatric surgery represents the most efficient therapy for severe obesity. It reduces the size of fat stores or the amount of body fat gain. The bariatric surgery procedures currently used include Roux-en-Y gastric bypass and sleeve gastrectomy, which are the most commonly performed procedures. Other procedures are laparoscopic adjustable gastric banding and biliopancreatic diversion. The latter represents the most effective surgery for treatment of severe obesity as well as type 2 diabetes. Bariatric surgery reduces energy intake by restricting the size of the stomach reservoir and causing malabsorption, as in the case of biliopancreatic diversion...
August 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28739097/surgery-for-diabetes-clinical-and-mechanistic-aspects
#18
REVIEW
Jordanna Kapeluto, André Tchernof, Laurent Biertho
According to the most recent publication by the Canadian Public Health Agency, obesity affects 25% of adults. In addition, there is a clear association between the recent rise in obesity and the increased prevalence of type 2 diabetes. Medical therapy for obesity has shown limited long-term effectiveness, and surgical treatment is now recognized by medical authorities as part of the armamentarium for the management of type 2 diabetes in severely obese patients. The current indications for obesity surgery and postoperative management are reviewed...
August 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28738740/a-systematic-review-of-the-effectiveness-of-task-specific-rehabilitation-interventions-for-improving-independent-sitting-and-standing-function-in-spinal-cord-injury
#19
Cynthia M Tse, Amanda E Chisholm, Tania Lam, Janice J Eng
Context Impaired balance function after a spinal cord injury (SCI) hinders performance of daily activities. Objective To assess the evidence on the effectiveness of task-specific training on sitting and standing function in individuals with SCI across the continuum of care. Methods A systematic search was conducted on literature published to June 2016 using people (acute or chronic SCI), task-specific interventions compared to conventional physical therapy, and outcome (sitting or standing balance function)...
July 24, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28736754/age-related-macular-degeneration-in-a-randomized-controlled-trial-of-low-dose-aspirin-rationale-and-study-design-of-the-aspree-amd-study
#20
Liubov Robman, Robyn Guymer, Robyn Woods, Stephanie Ward, Rory Wolfe, James Phung, Lauren Hodgson, Galina Makeyeva, Khin Zaw Aung, Tom Gilbert, Jessica Lockery, Y-Anh Le-Pham, Suzanne Orchard, Elsdon Storey, Walter Abhayaratna, Daniel Reid, Michael E Ernst, Mark Nelson, Christopher Reid, John McNeil
PURPOSE: Although aspirin therapy is used widely in older adults for prevention of cardiovascular disease, its impact on the incidence, progression and severity of age-related macular degeneration (AMD) is uncertain. The effect of low-dose aspirin on the course of AMD will be evaluated in this clinical trial. DESIGN: A sub-study of the 'ASPirin in Reducing Events in the Elderly' (ASPREE) trial, ASPREE-AMD is a 5-year follow-up double-blind, placebo-controlled, randomized trial of the effect of 100 mg daily aspirin on the course of AMD in 5000 subjects aged 70 years or older, with normal cognitive function and without cardiovascular disease at baseline...
June 2017: Contemporary Clinical Trials Communications
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