Christopher O Audu, William J Melvin, Amrita D Joshi, Sonya J Wolf, Jadie Y Moon, Frank M Davis, Emily C Barrett, Kevin D Mangum, Hongping Deng, Xianying Xing, Rachel Wasikowski, Lam C Tsoi, Sriganesh B Sharma, Tyler M Bauer, James Shadiow, Matthew A Corriere, Andrea T Obi, Steven L Kunkel, Benjamin Levi, Bethany B Moore, Johann E Gudjonsson, Andrew M Smith, Katherine A Gallagher
Macrophage plasticity is critical for normal tissue repair following injury. In pathologic states such as diabetes, macrophage plasticity is impaired, and macrophages remain in a persistent proinflammatory state; however, the reasons for this are unknown. Here, using single-cell RNA sequencing of human diabetic wounds, we identified increased JMJD3 in diabetic wound macrophages, resulting in increased inflammatory gene expression. Mechanistically, we report that in wound healing, JMJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 signaling...
September 20, 2022: Cellular & Molecular Immunology