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Jmjd3 signalling

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https://www.readbyqxmd.com/read/27532872/musashi-mediated-expression-of-jmjd3-a-h3k27me3-demethylase-is-involved-in-foamy-macrophage-generation-during-mycobacterial-infection
#1
Sahana Holla, Praveen Prakhar, Vikas Singh, Anupama Karnam, Tanushree Mukherjee, Kasturi Mahadik, Pankti Parikh, Amit Singh, R S Rajmani, Subbaraya G Ramachandra, Kithiganahalli Narayanaswamy Balaji
Foamy macrophages (FM)s harbor lipid bodies that not only assist mycobacterial persistence within the granulomas but also are sites for intracellular signaling and inflammatory mediators which are essential for mycobacterial pathogenesis. However, molecular mechanisms that regulate intracellular lipid accumulation in FMs during mycobacterial infection are not clear. Here, we report for the first time that jumonji domain containing protein (JMJD)3, a demethylase of the repressive H3K27me3 mark, orchestrates the expression of M...
August 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27456830/role-of-serum-amyloid-a-granulocyte-macrophage-colony-stimulating-factor-and-bone-marrow-granulocyte-monocyte-precursor-expansion-in-segmented-filamentous-bacterium-mediated-protection-from-entamoeba-histolytica
#2
Stacey L Burgess, Mahmoud Saleh, Carrie A Cowardin, Erica Buonomo, Zannatun Noor, Koji Watanabe, Mayuresh Abhyankar, Stephane Lajoie, Marsha Wills-Karp, William A Petri
Intestinal segmented filamentous bacteria (SFB) protect from ameba infection, and protection is transferable with bone marrow dendritic cells (BMDCs). SFB cause an increase in serum amyloid A (SAA), suggesting that SAA might mediate SFB's effects on BMDCs. Here we further explored the role of bone marrow in SFB-mediated protection. Transient gut colonization with SFB or SAA administration alone transiently increased the H3K27 histone demethylase Jmjd3, persistently increased bone marrow Csf2ra expression and granulocyte monocyte precursors (GMPs), and protected from ameba infection...
October 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27133168/two-conserved-histone-demethylases-regulate-mitochondrial-stress-induced-longevity
#3
Carsten Merkwirth, Virginija Jovaisaite, Jenni Durieux, Olli Matilainen, Sabine D Jordan, Pedro M Quiros, Kristan K Steffen, Evan G Williams, Laurent Mouchiroud, Sarah U Tronnes, Virginia Murillo, Suzanne C Wolff, Reuben J Shaw, Johan Auwerx, Andrew Dillin
Across eukaryotic species, mild mitochondrial stress can have beneficial effects on the lifespan of organisms. Mitochondrial dysfunction activates an unfolded protein response (UPR(mt)), a stress signaling mechanism designed to ensure mitochondrial homeostasis. Perturbation of mitochondria during larval development in C. elegans not only delays aging but also maintains UPR(mt) signaling, suggesting an epigenetic mechanism that modulates both longevity and mitochondrial proteostasis throughout life. We identify the conserved histone lysine demethylases jmjd-1...
May 19, 2016: Cell
https://www.readbyqxmd.com/read/27102442/jmjd3-promotes-survival-of-diffuse-large-b-cell-lymphoma-subtypes-via-distinct-mechanisms
#4
Yan Zhang, Long Shen, Dwayne G Stupack, Nan Bai, Jing Xun, Guosheng Ren, Jihong Han, Luyuan Li, Yunping Luo, Rong Xiang, Xiaoyue Tan
JMJD3 (Jumonji domain containing-3), a histone H3 Lys27 (H3K27) demethylase, has been reported to be involved in the antigen-driven differentiation of germinal center B-cells. However, insight into the mechanism of JMJD3 in DLBCL (Diffuse large B-cell lymphoma) progression remains poorly understood. In this study, we investigated the subtype-specific JMJD3-dependent survival effects in DLBCL. Our data showed that in the ABC subtype, silencing-down of JMJD3 inhibited interferon regulatory factor 4 (IRF4) expression in a demethylase activity-dependent fashion...
May 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/26699812/cu-zn-superoxide-dismutase-mediated-redox-regulation-of-jumonji-domain-containing-3-modulates-macrophage-polarization-and-pulmonary-fibrosis
#5
Chao He, Jennifer L Larson-Casey, Linlin Gu, Alan J Ryan, Shubha Murthy, A Brent Carter
M2 macrophages are implicated in the development of pulmonary fibrosis as they generate profibrotic signals. The polarization process, at least in part, is regulated by epigenetic modulation. Because Cu,Zn-superoxide dismutase-induced H2O2 can polarize macrophages to a profibrotic M2 phenotype, we hypothesized that modulation of the redox state of the cell is involved in the epigenetic modulation of the macrophage phenotype. In this study, we show that signal transducer and activator of transcription 6 (STAT6) regulates Jumonji domain containing (Jmjd) 3, a histone H3 lysine 27 demethylase, and mutation of a redox-sensitive cysteine in STAT6 attenuates jmjd3 expression...
July 2016: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/26399931/epigenetic-modulation-in-periodontitis-interaction-of-adiponectin-and-jmjd3-irf4-axis-in-macrophages
#6
Dongying Xuan, Qianqian Han, Qisheng Tu, Lan Zhang, Liming Yu, Dana Murry, Tianchi Tu, Yin Tang, Jane B Lian, Gary S Stein, Paloma Valverde, Jincai Zhang, Jake Chen
Emerging evidence suggests an important role for epigenetic mechanisms in modulating signals during macrophage polarization and inflammation. JMJD3, a JmjC family histone demethylase necessary for M2 polarization is also required for effective induction of multiple M1 genes by lipopolysaccharide (LPS). However, the effects of JMJD3 to inflammation in the context of obesity remains unknown. To address this deficiency, we firstly examined the expression of JMJD3 in macrophage isolated from bone marrow and adipose tissue of diet induced obesity (DIO) mice...
May 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/25843056/selective-inhibition-of-prostaglandin-e2-receptors-ep2-and-ep4-modulates-dna-methylation-and-histone-modification-machinery-proteins-in-human-endometriotic-cells
#7
Joe A Arosh, JeHoon Lee, Anna Starzinski-Powitz, Sakhila K Banu
Endometriosis is an inflammatory gynecological disease of reproductive-age women. The prevalence of endometriosis is 5-10% in reproductive-age women. Modern medical treatments are directed to inhibit the action of estrogen in endometriotic cells. However, hormonal therapies targeting estrogen can be prescribed only for a short time because of their undesirable side effects. Recent studies from our laboratory, using human endometriotic epithelial cell line 12Z and stromal cell line 22B derived from red lesion, discovered that selective inhibition of prostaglandin E2 (PGE2) receptors EP2 and EP4 inhibits adhesion, invasion, growth, and survival of 12Z and 22B cells by modulating integrins, MMPs and TIMPs, cell cycle, survival, and intrinsic apoptotic pathways, suggesting multiple epigenetic mechanisms...
July 5, 2015: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/25370275/an-epigenetic-switch-induced-by-shh-signalling-regulates-gene-activation-during-development-and-medulloblastoma-growth
#8
Xuanming Shi, Zilai Zhang, Xiaoming Zhan, Mou Cao, Takashi Satoh, Shizuo Akira, Karl Shpargel, Terry Magnuson, Qingtian Li, Rongfu Wang, Chaochen Wang, Kai Ge, Jiang Wu
The Sonic hedgehog (Shh) signalling pathway plays important roles during development and in cancer. Here we report a Shh-induced epigenetic switch that cooperates with Gli to control transcription outcomes. Before induction, poised Shh target genes are marked by a bivalent chromatin domain containing a repressive histone H3K27me3 mark and an active H3K4me3 mark. Shh activation induces a local switch of epigenetic cofactors from the H3K27 methyltransferase polycomb repressive complex 2 (PRC2) to an H3K27me3 demethylase Jmjd3/Kdm6b-centred coactivator complex...
November 5, 2014: Nature Communications
https://www.readbyqxmd.com/read/24925089/histone-demethylase-jumonji-d3-jmjd3-kdm6b-at-the-nexus-of-epigenetic-regulation-of-inflammation-and-the-aging-process
#9
REVIEW
Antero Salminen, Kai Kaarniranta, Mikko Hiltunen, Anu Kauppinen
Histone methylation is involved in the epigenetic control of immune responses and cellular senescence. Jumonji domain-containing protein 3 (JMJD3), also called lysine-specific demethylase 6B (KDM6b), is an inducible histone demethylase which enhances immune responses and can trigger cellular senescence. JMJD3 potentiates gene expression by demethylating repressive H3K27me3 epigenetic marks in promoters and gene bodies. Moreover, JMJD3 also stimulates transcription in a demethylase-independent manner by mediating interactions between chromatin modifiers...
October 2014: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/24646476/the-localization-of-histone-h3k27me3-demethylase-jmjd3-is-dynamically-regulated
#10
Yasunao F Kamikawa, Mary E Donohoe
Jmjd3 is required for cellular differentiation and senescence, and inhibits the induction of pluripotent stem cells by demethylating histone 3 lysine 27 trimethylation (H3K27me3). Although recent studies reveal crucial biological roles for Jmjd3, it is unclear how its demethylase activity is controlled. Here, we show that nuclear localization of Jmjd3 is required for effective demethylation of H3K27me3. Our subcellular localization analysis of Jmjd3 shows that the N-terminal region of the protein is responsible for its nuclear placement, whereas the C-terminal region harboring the catalytic Jumonji C (JmjC) domain cannot situate into the nucleus...
June 2014: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/24500110/linking-stat-and-tlr-signaling-in-microglia-a-new-role-for-the-histone-demethylase-jmjd3
#11
COMMENT
Uwe-Karsten Hanisch
No abstract text is available yet for this article.
March 2014: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/24097101/the-signal-transducers-stat1-and-stat3-and-their-novel-target-jmjd3-drive-the-expression-of-inflammatory-genes-in-microglia
#12
Piotr Przanowski, Michal Dabrowski, Aleksandra Ellert-Miklaszewska, Michal Kloss, Jakub Mieczkowski, Beata Kaza, Anna Ronowicz, Feng Hu, Arkadiusz Piotrowski, Helmut Kettenmann, Jan Komorowski, Bozena Kaminska
UNLABELLED: Most neurological diseases are associated with chronic inflammation initiated by the activation of microglia, which produce cytotoxic and inflammatory factors. Signal transducers and activators of transcription (STATs) are potent regulators of gene expression but contribution of particular STAT to inflammatory gene expression and STAT-dependent transcriptional networks underlying brain inflammation need to be identified. In the present study, we investigated the genomic distribution of Stat binding sites and the role of Stats in the gene expression in lipopolysaccharide (LPS)-activated primary microglial cultures...
March 2014: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/24078252/genome-wide-profiling-reveals-stimulus-specific-functions-of-p53-during-differentiation-and-dna-damage-of-human-embryonic-stem-cells
#13
Kadir C Akdemir, Abhinav K Jain, Kendra Allton, Bruce Aronow, Xueping Xu, Austin J Cooney, Wei Li, Michelle Craig Barton
How tumor suppressor p53 selectively responds to specific signals, especially in normal cells, is poorly understood. We performed genome-wide profiling of p53 chromatin interactions and target gene expression in human embryonic stem cells (hESCs) in response to early differentiation, induced by retinoic acid, versus DNA damage, caused by adriamycin. Most p53-binding sites are unique to each state and define stimulus-specific p53 responses in hESCs. Differentiation-activated p53 targets include many developmental transcription factors and, in pluripotent hESCs, are bound by OCT4 and NANOG at chromatin enriched in both H3K27me3 and H3K4me3...
January 2014: Nucleic Acids Research
https://www.readbyqxmd.com/read/23856522/jmjd3-controls-mesodermal-and-cardiovascular-differentiation-of-embryonic-stem-cells
#14
Kisho Ohtani, Cong Zhao, Gergana Dobreva, Yosif Manavski, Britta Kluge, Thomas Braun, Michael A Rieger, Andreas M Zeiher, Stefanie Dimmeler
RATIONALE: The developmental role of the H3K27 demethylases Jmjd3, especially its epigenetic regulation at target genes in response to upstream developmental signaling, is unclear. OBJECTIVE: To determine the role of Jmjd3 during mesoderm and cardiovascular lineage commitment. METHODS AND RESULTS: Ablation of Jmjd3 in mouse embryonic stem cells does not affect the maintenance of pluripotency and self-renewal but compromised mesoderm and subsequent endothelial and cardiac differentiation...
September 13, 2013: Circulation Research
https://www.readbyqxmd.com/read/23765228/toll-like-receptor-alterations-in-myelodysplastic-syndrome
#15
Y Wei, S Dimicoli, C Bueso-Ramos, R Chen, H Yang, D Neuberg, S Pierce, Y Jia, H Zheng, H Wang, X Wang, M Nguyen, S A Wang, B Ebert, R Bejar, R Levine, O Abdel-Wahab, M Kleppe, I Ganan-Gomez, H Kantarjian, G Garcia-Manero
Recent studies have implicated the innate immunity system in the pathogenesis of myelodysplastic syndromes (MDS). Toll-like receptor (TLR) genes encode key innate immunity signal initiators. We recently identified multiple genes, known to be regulated by TLRs, to be overexpressed in MDS bone marrow (BM) CD34+ cells, and hypothesized that TLR signaling is abnormally activated in MDS. We analyzed a large cohort of MDS cases and identified TLR1, TLR2 and TLR6 to be significantly overexpressed in MDS BM CD34+ cells...
September 2013: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/23748155/epigenetic-induction-of-the-ink4a-arf-locus-prevents-schwann-cell-overproliferation-during-nerve-regeneration-and-after-tumorigenic-challenge
#16
Jose Antonio Gomez-Sanchez, Clara Gomis-Coloma, Cruz Morenilla-Palao, Gloria Peiro, Eduard Serra, Manuel Serrano, Hugo Cabedo
The number of Schwann cells is fitted to axonal length in peripheral nerves. This relationship is lost when tumorigenic stimuli induce uncontrolled Schwann cell proliferation, generating tumours such us neurofibromas and schwannomas. Schwann cells also re-enter the cell cycle following nerve injury during the process of Wallerian degeneration. In both cases proliferation is finally arrested. We show that in neurofibroma, the induction of Jmjd3 (jumonji domain containing 3, histone lysine demethylase) removes trimethyl groups on lysine-27 of histone-H3 and epigenetically activates the Ink4a/Arf-locus, forcing Schwann cells towards replicative senescence...
July 2013: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/23711388/proteomic-changes-induced-by-histone-demethylase-jmjd3-in-tnf-alpha-treated-human-monocytic-thp-1-cells
#17
Amitabh Das, Nando Dulal Das, Kyoung Hwa Jung, Ji Hyun Park, Hyung Tae Lee, DalMuri Han, Mi Ran Choi, Sung Chul Kang, Young Gyu Chai
JMJD3, a Jumonji C family histone demethylase, plays an important role in the regulation of inflammation induced by the transcription factor nuclear factor-kappa B (NF-κB) in response to various stimuli. JMJD3 is a histone-3 lysine-27 trimethylation (H3K27me3) demethylase, a histone mark associated with transcriptional repression and activation of a diverse set of genes. The present study assessed stable JMJD3 knockdown (KD)-dependent proteomic profiling in human leukemia monocyte (THP-1) cells to analyze the JMJD3-mediated differential changes of marker expression in inflammatory cells...
November 2013: Molecular Immunology
https://www.readbyqxmd.com/read/23593167/focused-examination-of-the-intestinal-epithelium-reveals-transcriptional-signatures-consistent-with-disturbances-in-enterocyte-maturation-and-differentiation-during-the-course-of-siv-infection
#18
Mahesh Mohan, Deepak Kaushal, Pyone P Aye, Xavier Alvarez, Ronald S Veazey, Andrew A Lackner
The Gastrointestinal (GI) tract plays a pivotal role in AIDS pathogenesis as it is the primary site for viral transmission, replication and CD4(+) T cell destruction. Accordingly, GI disease (enteropathy) has become a well-known complication and a driver of AIDS progression. To better understand the molecular mechanisms underlying GI disease we analyzed global gene expression profiles sequentially in the intestinal epithelium of the same animals before SIV infection and at 21 and 90 days post infection (DPI)...
2013: PloS One
https://www.readbyqxmd.com/read/23584530/the-histone-demethylase-jmjd3-sequentially-associates-with-the-transcription-factors-tbx3-and-eomes-to-drive-endoderm-differentiation
#19
Apriliana E R Kartikasari, Josie X Zhou, Murtaza S Kanji, David N Chan, Arjun Sinha, Anne Grapin-Botton, Mark A Magnuson, William E Lowry, Anil Bhushan
Stem cell differentiation depends on transcriptional activation driven by lineage-specific regulators as well as changes in chromatin organization. However, the coordination of these events is poorly understood. Here, we show that T-box proteins team up with chromatin modifying enzymes to drive the expression of the key lineage regulator, Eomes during endodermal differentiation of embryonic stem (ES) cells. The Eomes locus is maintained in a transcriptionally poised configuration in ES cells. During early differentiation steps, the ES cell factor Tbx3 associates with the histone demethylase Jmjd3 at the enhancer element of the Eomes locus to allow enhancer-promoter interactions...
May 15, 2013: EMBO Journal
https://www.readbyqxmd.com/read/23573229/utx-is-required-for-proper-induction-of-ectoderm-and-mesoderm-during-differentiation-of-embryonic-stem-cells
#20
Cristina Morales Torres, Anne Laugesen, Kristian Helin
Embryonic development requires chromatin remodeling for dynamic regulation of gene expression patterns to ensure silencing of pluripotent transcription factors and activation of developmental regulators. Demethylation of H3K27me3 by the histone demethylases Utx and Jmjd3 is important for the activation of lineage choice genes in response to developmental signals. To further understand the function of Utx in pluripotency and differentiation we generated Utx knockout embryonic stem cells (ESCs). Here we show that Utx is not required for the proliferation of ESCs, however, Utx contributes to the establishment of ectoderm and mesoderm in vitro...
2013: PloS One
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