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https://www.readbyqxmd.com/read/28642967/strategies-for-characterization-of-enzymatic-nucleic-acids
#1
Fatemeh Javadi-Zarnaghi, Claudia Höbartner
Practical application of enzymatic nucleic acids has received more attention in recent years. Understanding the mechanism of catalysis and availability of information on potentials and limitations of these enzymes expands their application scope. A general approach for characterization of functional macromolecules including enzymatic nucleic acids is to perturb a specific set of condition and to follow the perturbation effect by biophysical and biochemical methods. This chapter reviews several perturbation strategies for functional nucleic acids, including deletion, mutation, and modifications of backbone and nucleobases, and consequent kinetic analysis, spectroscopic investigations, and probing assays...
June 23, 2017: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/28638073/plasmon-induced-selective-carbon-dioxide-conversion-on-earth-abundant-aluminum-cuprous-oxide-antenna-reactor-nanoparticles
#2
Hossein Robatjazi, Hangqi Zhao, Dayne F Swearer, Nathaniel J Hogan, Linan Zhou, Alessandro Alabastri, Michael J McClain, Peter Nordlander, Naomi J Halas
The rational combination of plasmonic nanoantennas with active transition metal-based catalysts, known as 'antenna-reactor' nanostructures, holds promise to expand the scope of chemical reactions possible with plasmonic photocatalysis. Here, we report earth-abundant embedded aluminum in cuprous oxide antenna-reactor heterostructures that operate more effectively and selectively for the reverse water-gas shift reaction under milder illumination than in conventional thermal conditions. Through rigorous comparison of the spatial temperature profile, optical absorption, and integrated electric field enhancement of the catalyst, we have been able to distinguish between competing photothermal and hot-carrier driven mechanistic pathways...
June 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28616760/liver-segmentation-indications-techniques-and-future-directions
#3
REVIEW
Akshat Gotra, Lojan Sivakumaran, Gabriel Chartrand, Kim-Nhien Vu, Franck Vandenbroucke-Menu, Claude Kauffmann, Samuel Kadoury, Benoît Gallix, Jacques A de Guise, An Tang
OBJECTIVES: Liver volumetry has emerged as an important tool in clinical practice. Liver volume is assessed primarily via organ segmentation of computed tomography (CT) and magnetic resonance imaging (MRI) images. The goal of this paper is to provide an accessible overview of liver segmentation targeted at radiologists and other healthcare professionals. METHODS: Using images from CT and MRI, this paper reviews the indications for liver segmentation, technical approaches used in segmentation software and the developing roles of liver segmentation in clinical practice...
June 14, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28615754/telepsychiatry-in-india-where-do-we-stand-a-comparative-review-between-global-and-indian-telepsychiatry-programs
#4
REVIEW
Subrata Naskar, Robin Victor, Himabrata Das, Kamal Nath
A wide discrepancy exists in India between the existing mental healthcare repertoire and the alarmingly high burden of individuals requiring immediate attention from requisite mental healthcare services. Providing equitable mental healthcare across a vast country characterized by profound cultural variations and territorial caveats has remained a major public health concern. Against this gloomy backdrop, the emergence of distant communications technology offers solace and optimism as an ingenious approach to bridge the existing gap between clients and mental health professionals...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28614465/implementation-strategy-for-advanced-practice-nursing-in-primary-health-care-in-latin-america-and-the-caribbean
#5
David Oldenburger, Silvia Helena De Bortoli Cassiani, Denise Bryant-Lukosius, Ruta Kristina Valaitis, Andrea Baumann, Joyce Pulcini, Ruth Martin-Misener
SYNOPSIS Advanced practice nursing (APN) is a term used to describe a variety of possible nursing roles operating at an advanced level of practice. Historically, APN roles haves evolved informally, out of the need to improve access to health care services for at-risk and disadvantaged populations and for those living in underserved rural and remote communities. To address health needs, especially ones related to primary health care, nurses acquired additional skills through practice experience, and over time they developed an expanded scope of practice...
June 8, 2017: Revista Panamericana de Salud Pública, Pan American Journal of Public Health
https://www.readbyqxmd.com/read/28610621/exploration-of-the-methodological-quality-and-clinical-usefulness-of-a-cross-sectional-sample-of-published-guidance-about-exercise-training-and-physical-activity-for-the-secondary-prevention-of-coronary-heart-disease
#6
Bridget Abell, Paul Glasziou, Tammy Hoffmann
BACKGROUND: Clinicians are encouraged to use guidelines to assist in providing evidence-based secondary prevention to patients with coronary heart disease. However, the expanding number of publications providing guidance about exercise training may confuse cardiac rehabilitation clinicians. We therefore sought to explore the number, scope, publication characteristics, methodological quality, and clinical usefulness of published exercise-based cardiac rehabilitation guidance. METHODS: We included publications recommending physical activity, exercise or cardiac rehabilitation for patients with coronary heart disease...
June 13, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28609611/selective-aliphatic-carbon-carbon-bond-activation-by-rhodium-porphyrin-complexes
#7
Ching Tat To, Kin Shing Chan
The carbon-carbon bond activation of organic molecules with transition metal complexes is an attractive transformation. These reactions form transition metal-carbon bonded intermediates, which contribute to fundamental understanding in organometallic chemistry. Alternatively, the metal-carbon bond in these intermediates can be further functionalized to construct new carbon-(hetero)atom bonds. This methodology promotes the concept that the carbon-carbon bond acts as a functional group, although carbon-carbon bonds are kinetically inert...
June 13, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28606391/tensions-in-relation-how-peer-support-is-experienced-and-received-in-a-hepatitis-c-treatment-intervention
#8
Oliver Bonnington, Magdalena Harris
BACKGROUND: Peer support and involvement is recognised as a vital component of hepatitis C (HCV) treatment provision for marginalised populations, such as people who inject drugs (PWID). Developments in HCV treatments enable increased provision in community settings - expanding the possibilities for meaningful peer involvement in HCV treatment plans. To date, HCV peer support has generally been viewed as a positive intervention, with little critical reflection on the ways social structures, policies, health and drug services and social identity impact on how peer support is experienced and received...
June 9, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28597661/metal-free-oxidative-coupling-of-aromatic-alkenes-with-thiols-leading-to-e-vinyl-sulfones
#9
Leilei Wang, Huilan Yue, Daoshan Yang, Huanhuan Cui, Minghui Zhu, Jinming Wang, Wei Wei, Hua Wang
A facile I2O5-mediated direct oxidative coupling of aromatic alkenes with thiols toward vinyl sulfones has been developed under metal-free conditions. This methodology provides a convenient and efficient approach to various (E)-vinyl sulfones from readily-available starting materials with excellent regioselectivity. The present oxidative coupling reaction, not only expands the scope of functionalization of alkenes with thiols, but also makes it a practical and powerful complement to traditional methods for the synthesis of (E)-vinyl sulfones...
June 9, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28585878/practical-considerations-on-the-use-of-continuous-glucose-monitoring-in-pediatrics-and-older-adults-and-nonadjunctive-use
#10
Gregory P Forlenza, Nicholas B Argento, Lori M Laffel
Clinical use of continuous glucose monitoring (CGM) devices has grown over the past 15 years from a niche concept to becoming standard of care for patients with type 1 diabetes (T1D). With the December 2016 Food and Drug Administration approval for diabetes treatment decisions directly from CGM values (nonadjunctive use) without finger-stick confirmation, the uptake and scope of CGM use will likely further expand. With this expansion, it is important to consider the role and impact of CGM technology in specific settings and high-risk populations, such as the young and the elderly...
June 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28556871/nursing-work-in-long-term-care-an-integrative-review
#11
Jed Montayre, Jasmine Montayre
Evidence suggests that delivery of good nursing care in long-term care (LTC) facilities is reflected in nurses' descriptions of the factors and structures that affect their work. Understanding the contemporary nature of nursing work in aged care will influence policies for improving current work structures in this practice setting. The current review aims to present a contemporary perspective of RNs' work in LTC facilities. A comprehensive search and purposeful selection of the literature was conducted using CINAHL, PubMed, Medline, Scopus, and Google Scholar databases...
May 30, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/28552179/informing-the-homeopathic-practice-for-turkish-pharmacists-reviewing-the-example-of-portuguese-community-pharmacies
#12
Afonso Miguel Cavaco, Miray Arslan, Sevgi Şar
INTRODUCTION: Alternative and complementary therapy systems, such as homeopathy, have long been used around the world. Since 1995 homeopathy has been officially recognized in Europe as a system of medicine or a medical specialty. Portuguese community pharmacists have long-standing experience with homeopathic products. By contrast, healthcare professionals in Turkey are less experienced with homeopathic practice although there is a new regulatory setting in place. There are a limited number of studies addressing pharmacists' role within the homeopathic system...
May 2017: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/28536089/smart-devices-for-older-adults-managing-chronic-disease-a-scoping-review
#13
REVIEW
Ben Yb Kim, Joon Lee
BACKGROUND: The emergence of smartphones and tablets featuring vastly advancing functionalities (eg, sensors, computing power, interactivity) has transformed the way mHealth interventions support chronic disease management for older adults. Baby boomers have begun to widely adopt smart devices and have expressed their desire to incorporate technologies into their chronic care. Although smart devices are actively used in research, little is known about the extent, characteristics, and range of smart device-based interventions...
May 23, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28535315/early-career-outcomes-of-family-medicine-residency-graduates-exposed-to-innovative-flexible-longitudinal-tracks
#14
Richard A Young, Dan Casey, Diana Singer, Elaine Waller, Patricia A Carney
BACKGROUND AND OBJECTIVES: The Preparing the Personal Physician for Practice (P4) project used a case series design to study innovations in the content, length, structure, and location of residency training in 14 geographically diverse family medicine programs between 2007 and 2012. We aimed to explore how offering flexible longitudinal tracks (FLT) affected graduates' scope of practice, particularly in maternal child health (MCH), which included at least 17 months of focused training that increased each year over 4 years...
May 2017: Family Medicine
https://www.readbyqxmd.com/read/28520971/mass-spectrometry-for-serine-adp-ribosylation-think-o-glycosylation
#15
Juan J Bonfiglio, Thomas Colby, Ivan Matic
Protein ADP-ribosylation (ADPr), a biologically and clinically important post-translational modification, exerts its functions by targeting a variety of different amino acids. Its repertoire recently expanded to include serine ADPr, which is emerging as an important and widespread signal in the DNA damage response. Chemically, serine ADPr (and more generally o-glycosidic ADPr) is a form of o-glycosylation, and its extreme lability renders it practically invisible to standard mass spectrometry approaches, often leading to erroneous localizations...
May 18, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28515199/are-healthcare-aides-underused-in-long-term-care-a-cross-sectional-study-on-continuing-care-facilities-in-canada
#16
Mubashir A Arain, Siegrid Deutschlander, Paola Charland
OBJECTIVES: Over the last 10 years, appropriate workforce utilisation has been an important discussion among healthcare practitioners and policy-makers. The role of healthcare aides (HCAs) has also expanded to improve their utilisation. This evolving role of HCAs in Canada has prompted calls for standardised training, education and scope of practice for HCAs. The purpose of this research was to examine the differences in HCAs training and utilisation in continuing care facilities. DESIGN: From June 2014 to July 2015, we conducted a mixed-method study on HCA utilisation in continuing care...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28507655/how-are-pharmacists-in-ontario-adapting-to-practice-change-results-of-a-qualitative-analysis-using-kotter-s-change-management-model
#17
Beatriz Teixeira, Paul A M Gregory, Zubin Austin
BACKGROUND: The pace of practice change in community pharmacy over the past decade has been significant, yet there is little evidence documenting implementation of change in the profession. METHODS: Kotter's change management model was selected as a theoretical framework for this exploratory qualitative study. Community pharmacists were interviewed using a semistructured protocol based on Kotter's model. Data were analyzed and coded using a constant-comparative iterative method aligned with the stages of change management outlined by Kotter...
May 2017: Canadian Pharmacists Journal: CPJ, Revue des Pharmaciens du Canada: RPC
https://www.readbyqxmd.com/read/28494847/history-of-cupping-hijama-a-narrative-review-of-literature
#18
REVIEW
Naseem Akhtar Qureshi, Gazzaffi Ibrahim Ali, Tamer Shaban Abushanab, Ahmed Tawfik El-Olemy, Meshari Saleh Alqaed, Ibrahim S El-Subai, Abdullah M N Al-Bedah
Cupping (Hijama in Arabic) is an ancient, holistic method for the treatment of a variety of diseases. Though the exact origin of cupping therapy is a matter of controversy, its use has been documented in early Egyptian and Chinese medical practices. Diverse human civilizations have contributed to the historical development and continuation of cupping therapy. This narrative review describes the history of cupping, historical definitions, cupping instruments and uses of cupping therapy. Electronic searches of relevant databases (PubMed, Google Scholar and OvidSP) were conducted using keywords and Boolean operators...
May 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28486999/gene-expression-profiling-and-expanded-immunohistochemistry-tests-to-guide-selection-of-chemotherapy-regimens-in-breast-cancer-management-a-systematic-review
#19
Alison Scope, Munira Essat, Abdullah Pandor, Rachid Rafia, Sue E Ward, Lynda Wyld, Simon Cross, Helen Buckley Woods
OBJECTIVES: The aim of this report was to assess the clinical effectiveness of two Gene expression profiling (GEP) and two expanded immunohistochemistry (IHC) tests compared with current prognostic tools in guiding the use of adjuvant chemotherapy in patients with early breast cancer. METHODS: A systematic review of the evidence on clinical effectiveness of OncotypeDX, IHC4, MammaPrint, and Mammostrat, compared with current clinical practice using clinicopathological parameters, in women with early breast cancer was conducted...
May 10, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/28483137/expanded-roles-of-registered-nurses-in-primary-care-delivery-of-the-future
#20
Laurie Bauer, Thomas Bodenheimer
BACKGROUND: Primary care in the United States is changing: practice size is increasing, there is a growing shortage of primary care practitioners, and there is a heightened prevalence of chronic disease. Given these trends, it is likely that registered nurses will become important members of the primary care team. PURPOSE: This paper explores the challenges and opportunities in primary care delivery in the 21st century and examines the likelihood of expanded roles for RNs to improve quality and add capacity to the primary care workforce...
April 7, 2017: Nursing Outlook
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