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https://www.readbyqxmd.com/read/29332247/practical-advantages-of-contrast-enhanced-ultrasound-in-abdominopelvic-radiology
#1
Praveen Ganti Ranganath, Michelle L Robbin, Susan J Back, Edward G Grant, David T Fetzer
Computed tomography (CT) and magnetic resonance imaging (MRI) are two of the workhorse modalities of abdominopelvic radiology. However, these modalities are not without patient- and technique-specific limitations that may prevent a timely and accurate diagnosis. Contrast-enhanced ultrasound (CEUS) is an effective, rapid, and cost-effective imaging modality with expanding clinical utility in the United States. In this pictorial essay, we provide a case-based discussion demonstrating the practical advantages of CEUS in evaluating a variety of pathologies in which CT or MRI was precluded or insufficient...
January 13, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29331266/human-papilloma-virus-specific-t-cells-can-be-generated-from-na%C3%A3-ve-t-cells-for-use-as-an-immunotherapeutic-strategy-for-immunocompromised-patients
#2
Sarah E McCormack, Conrad Russell Y Cruz, Kaylor E Wright, Allison B Powell, Haili Lang, Cornelia Trimble, Michael D Keller, Ephraim Fuchs, Catherine M Bollard
Human papilloma virus (HPV) is a known cause of cervical cancer, squamous cell carcinoma and laryngeal cancer. Although treatments exist for HPV-associated malignancies, patients unresponsive to these therapies have a poor prognosis. Recent findings from vaccine studies suggest that T-cell immunity is essential for disease control. Because Epstein-Barr Virus (EBV)-specific T cells have been highly successful in treating or preventing EBV-associated tumors, we hypothesized that the development of a manufacturing platform for HPV-specific T cells from healthy donors could be used in a third-party setting to treat patients with high-risk/relapsed HPV-associated cancers...
January 10, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29330244/primary-care-physicians-struggle-with-current-adult-pneumococcal-vaccine-recommendations
#3
Laura P Hurley, Mandy A Allison, Tamara Pilishvili, Sean T O'Leary, Lori A Crane, Michaela Brtnikova, Brenda L Beaty, Megan C Lindley, Carolyn B Bridges, Allison Kempe
INTRODUCTION: In 2012, the Advisory Committee on Immunization Practices recommended 13-valent pneumococcal conjugate vaccine (PCV13) in series with 23-valent pneumococcal polysaccharide vaccine (PPSV23) for at-risk adults ≥19; in 2014, it expanded this recommendation to adults ≥65. Primary care physicians' practice, knowledge, attitudes, and beliefs regarding these recommendations are unknown. METHODS: Primary care physicians throughout the U.S. were surveyed by E-mail and post from December 2015 to January 2016...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29329796/the-evolving-face-of-myocardial-reperfusion-in-acute-coronary-syndromes-a-primer-for-the-internist
#4
REVIEW
R Jay Widmer, Peter M Pollak, Malcolm R Bell, Bernard J Gersh, Nandan S Anavekar
Acute coronary syndromes (ACSs) account for a large proportion of disease burden in the United States and worldwide, and our understanding of ACS management continues to evolve. In this review we take a practical approach to evaluating and treating a patient with ACS, focusing on the optimal timing and methods of coronary reperfusion. Beginning with initial assessment and risk stratification, a provider managing the patient with ACS must be able to expeditiously decide on and implement the correct guideline-directed pathway to optimize outcomes...
January 9, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29327813/computational-tools-for-the-identification-and-interpretation-of-sequence-motifs-in-immunopeptidomes
#5
REVIEW
Bruno Alvarez, Carolina Barra, Morten Nielsen, Massimo Andreatta
Recent advances in proteomics and mass-spectrometry have widely expanded the detectable peptide repertoire presented by major histocompatibility complex (MHC) molecules on the cell surface, collectively known as the immunopeptidome. Finely characterizing the immunopeptidome brings about important basic insights into the mechanisms of antigen presentation, but can also reveal promising targets for vaccine development and cancer immunotherapy. In this report, we describe a number of practical and efficient approaches to analyze immunopeptidomics data, discussing the identification of meaningful sequence motifs in various scenarios and considering current limitations...
January 12, 2018: Proteomics
https://www.readbyqxmd.com/read/29327397/translating-international-hiv-treatment-guidelines-into-local-priorities-in-indonesia
#6
Noor Tromp, Rozar Prawiranegara, Adiatma Siregar, Rudi Wisaksana, Lucas Pinxten, Juul Pinxten, Arry Lesmana Putra, Deni Sunjaya Lesmana, Maarten Jansen, Jan Hontelez, Scott Maurits, Febrina Maharani, Leon Bijlmakers, Rob Baltussen
OBJECTIVE: International guidelines recommend countries to expand Antiretroviral therapy (ART) to all HIV-infected individuals and establish local-level priorities in relation to other treatment, prevention and mitigation interventions through fair processes. However, no practical guidance is provided for such priority setting processes. Evidence-informed deliberative processes (EDPs) fill this gap and combine stakeholder deliberation to incorporate relevant social values with rational decision-making informed by evidence on these values...
January 12, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29325630/towards-precision-medicine
#7
Tanya Bardakjian, Pedro Gonzalez-Alegre
The concept of precision medicine, also referred to as individualized or personalized medicine, has recently gained traction in scientific, medical, and public spheres, and is frequently mentioned as the next model of healthcare delivery. Its goal is to integrate unique information obtained from a given patient to customize the care provided to achieve the best possible outcome. Although precision medicine is not fully implemented yet, its application is slowly infiltrating clinical practice, and the dream of individualizing healthcare to each patient is now closer to being fulfilled...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29325575/routinely-collected-data-for-randomized-trials-promises-barriers-and-implications
#8
REVIEW
Kimberly A Mc Cord, Rustam Al-Shahi Salman, Shaun Treweek, Heidi Gardner, Daniel Strech, William Whiteley, John P A Ioannidis, Lars G Hemkens
BACKGROUND: Routinely collected health data (RCD) are increasingly used for randomized controlled trials (RCTs). This can provide three major benefits: increasing value through better feasibility (reducing costs, time, and resources), expanding the research agenda (performing trials for research questions otherwise not amenable to trials), and offering novel design and data collection options (e.g., point-of-care trials and other designs directly embedded in routine care). However, numerous hurdles and barriers must be considered pertaining to regulatory, ethical, and data aspects, as well as the costs of setting up the RCD infrastructure...
January 11, 2018: Trials
https://www.readbyqxmd.com/read/29323425/evaluating-mid-upper-arm-circumference-z-score-as-a-determinant-of-nutrition-status
#9
Karen Stephens, April Escobar, Erika Nicole Jennison, Lindsey Vaughn, Rhonda Sullivan, Susan Abdel-Rahman
BACKGROUND: Mid-upper arm circumference (MUAC) z-score, has recently been listed as an independent indicator for pediatric malnutrition. This investigation examined the relationship between MUAC z-score and the z-scores for conventional indicators (ie, weight-for-length and body mass index) to expand the available evidence for nutrition classification z-score threshold ranges in U.S. practice settings. METHODS: This was a single-center study of children through 18 years of age seen between October 2015 and September 2016...
January 11, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29322250/lactate-metabolism-historical-context-prior-misinterpretations-and-current-understanding
#10
REVIEW
Brian S Ferguson, Matthew J Rogatzki, Matthew L Goodwin, Daniel A Kane, Zachary Rightmire, L Bruce Gladden
Lactate (La-) has long been at the center of controversy in research, clinical, and athletic settings. Since its discovery in 1780, La- has often been erroneously viewed as simply a hypoxic waste product with multiple deleterious effects. Not until the 1980s, with the introduction of the cell-to-cell lactate shuttle did a paradigm shift in our understanding of the role of La- in metabolism begin. The evidence for La- as a major player in the coordination of whole-body metabolism has since grown rapidly. La- is a readily combusted fuel that is shuttled throughout the body, and it is a potent signal for angiogenesis irrespective of oxygen tension...
January 10, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29319342/fat-as-productive-enactments-of-fat-in-an-australian-suburb
#11
Tanya Zivkovic, Megan Warin, Vivienne Moore, Paul Ward, Michelle Jones
By foregrounding positive and productive capacities of fat, we explore experiences of expanding, maintaining or diminishing body sizes to accommodate the different meanings and enactments of fat. Drawing on fieldwork conducted in a South Australian community that has experienced significant socio-economic disadvantage, we detail how the "problem" of fat in public health discourse is countered in the lived experience of people targeted for obesity intervention. In so doing, we attend to the multiple meanings and practices of fat that differ to the focus within public health interventions on the negative health consequences of overweight and obesity...
January 10, 2018: Medical Anthropology
https://www.readbyqxmd.com/read/29319092/synthesis-of-u-channelled-spherical-fex-coyni1-y-100-x-janus-colloidal-particles-with-excellent-electromagnetic-wave-absorption-performance
#12
Hao Li, Zhenming Cao, Jiayao Lin, Hui Zhao, Qiaorong Jiang, Zhiyuan Jiang, Honggang Liao, Qin Kuang, Zhaoxiong Xie
Due to their distinctive structure, inherently anisotropic properties and broad applications, Janus colloidal particles have attracted tremendous attention and it is significant to synthesize high yield Janus colloidal particles in a cost-effective and reliable way. On the other hand, due to the expanded electromagnetic interference problems, it is highly desired to develop excellent electromagnetic wave absorbing materials with an ultra-wide absorption bandwidth for practical application. Herein, a confined liquid-solid redox reaction strategy has been developed to fabricate a series of Fex(CoyNi1-y)100-x ternary alloy particles...
January 10, 2018: Nanoscale
https://www.readbyqxmd.com/read/29318829/-key-points-of-poverty-alleviation-of-chinese-herbal-medicine-industry-and-classification-of-recommended-chinese-herbal-medicines
#13
Lu-Qi Huang, Gang-Qiang Su, Xiao-Bo Zhang, Xiao-Ming Sun, Xiao-Jun Wu, Lan-Ping Guo, Meng Li, Hui Wang, Zhi-Xian Jing
To build a well-off society in an all-round way, eliminate poverty, improve people's livelihood and improve the level of social and economic development in poverty-stricken areas is the frontier issues of the government and science and technology workers at all levels. Chinese herbal medicine is the strategic resource of the people's livelihood, Chinese herbal medicine cultivation is an important part of China's rural poor population income. As most of the production of Chinese herbal medicine by the biological characteristics of their own and the interaction of natural ecological environment factors, showing a strong regional character...
November 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29318769/seeking-and-defining-the-special-in-specialist-mental-health-nursing-a-theoretical-construct
#14
Peter Santangelo, Nicholas Procter, Denise Fassett
In the context of an enduring debate about the distinct identity of mental health nursing, this qualitative study explored the nature, scope and consequences of mental health nursing practice. Data for interpretation were generated through interviews with 36 mental health nurses, five of their clients and one health care colleague, each of whom were asked to speak in as much detail as possible about what they believe is special about mental health nursing and what had influenced them to arrive at this understanding...
February 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29317119/noninvasive-ventilation-during-endoscopic-procedures-rationale-clinical-use-and-devices
#15
REVIEW
Marina Pieri, Giovanni Landoni, Luca Cabrini
Endoscopic procedures, such as transesophageal echocardiography, gastroscopy, and airway fibroscopy, routinely are performed in a heterogenous population of patients for diagnostic/interventional purposes (eg, transfemoral aortic valve replacement, airway fibroscopies, and intubation). Sedation frequently is administered to achieve an appropriate degree of patient compliance and procedure success. Patients with reduced respiratory reserve or those who are overly sedated, however, may develop hypoxia and respiratory failure during endoscopies, necessitating premature termination of the examination itself...
September 27, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29317001/video-based-learning-vs-traditional-lecture-for-instructing-emergency-medicine-residents-in-disaster-medicine-principles-of-mass-triage-decontamination-and-personal-protective-equipment
#16
Henry A Curtis, Karen Trang, Kevin W Chason, Paul D Biddinger
Introduction Great demands have been placed on disaster medicine educators. There is a need to develop innovative methods to educate Emergency Physicians in the ever-expanding body of disaster medicine knowledge. The authors sought to demonstrate that video-based learning (VBL) could be a promising alternative to traditional learning methods for teaching disaster medicine core competencies. Hypothesis/Problem The objective was to compare VBL to traditional lecture (TL) for instructing Emergency Medicine residents in the American College of Emergency Physicians (ACEP; Irving, Texas USA) disaster medicine core competencies of patient triage and decontamination...
January 10, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29316889/a-systematic-review-of-chronic-disease-management-interventions-in-primary-care
#17
Rebecca Reynolds, Sarah Dennis, Iqbal Hasan, Jan Slewa, Winnie Chen, David Tian, Sangeetha Bobba, Nicholas Zwar
BACKGROUND: Primary and community care are key settings for the effective management of long term conditions. We aimed to evaluate the pattern of health outcomes in chronic disease management interventions for adults with physical health problems implemented in primary or community care settings. METHODS: The methods were based on our previous review published in 2006. We performed database searches for articles published from 2006 to 2014 and conducted a systematic review with narrative synthesis using the Cochrane Effective Practice and Organisation of Care taxonomy to classify interventions and outcomes...
January 9, 2018: BMC Family Practice
https://www.readbyqxmd.com/read/29316831/school-nurse-perceptions-of-student-anxiety
#18
Michela A Muggeo, Golda S Ginsburg
Anxiety disorders are common in youth. Because somatic complaints are a hallmark feature of anxiety, these students frequently visit their school nurse, creating an ideal opportunity for nurses to identify and assist them. In an effort to better understand current practices, we surveyed a large sample ( N = 93) of school nurses. Results indicated that the majority of nurses perceived anxiety as the most prevalent mental health issue in their students. Moreover, the majority of nurses reported that they did not use any formal screening tool or intervention protocol and stated wanting to expand their training in anxiety intervention...
January 1, 2018: Journal of School Nursing: the Official Publication of the National Association of School Nurses
https://www.readbyqxmd.com/read/29312863/human-leukocyte-antigen-typing-and-crossmatch-a-comprehensive-review
#19
REVIEW
Mohammed Mahdi Althaf, Mohsen El Kossi, Jon Kim Jin, Ajay Sharma, Ahmed Mostafa Halawa
Renal transplantation remains the best option for patients suffering from end stage renal disease (ESRD). Given the worldwide shortage of organs and growing population of patients with ESRD, those waitlisted for a transplant is ever expanding. Contemporary crossmatch methods and human leukocyte antigen (HLA) typing play a pivotal role in improving organ allocation and afford better matches to recipients. Understanding crossmatch as well as HLA typing for renal transplantation and applying it in clinical practice is the key step to achieve a successful outcome...
December 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/29311531/new-perspectives-on-the-origin-of-korean-acupuncture-based-on-materials-from-xiaoyingzi-tomb-yanji-and-neighbouring-region
#20
In Uk Kang, Wung Seok Cha
This article discusses the development of early acupuncture needles as demonstrated by the artifacts excavated from the Northern part of the Yanji district, Jilin, China, during the Japanese colonial era (reported in 1941). Numerous bone needles, stone needles, and other medical devices were found in the Xiaoyingzi excavation. The stone needles from Xiaoyingzi can be categorized into three grades, based on length, of 8cm, 12-15cm, and 18cm. A set of round stones for massage were also discovered, along with obsidian blades...
December 2017: Ŭi Sahak
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