Vadim Mitrokhin, Andrei Bilichenko, Viktor Kazanski, Roman Schobik, Stanislav Shileiko, Veronika Revkova, Vladimir Kalsin, Olga Kamkina, Andre Kamkin, Mitko Mladenov
Human cardiac fibroblasts (HCFs) have mRNA transcripts that encode different mechanosensitive ion channels and channel regulatory proteins whose functions are not known yet. The primary goal of this work was to define the mechanosensitive ion channelome of HCFs. The most common type of cationic channel is the transient receptor potential (TRP) family, which is followed by the TWIK-related K+ channel (TREK), transmembrane protein 63 (TMEM63), and PIEZO channel (PIEZO) families. In the sodium-dependent NON-voltage-gated channel (SCNN) subfamily, only SCNN1D was shown to be highly expressed...
December 30, 2023: Experimental Biology and Medicine