keyword
https://read.qxmd.com/read/36113609/adverse-dermatologic-reactions-in-patients-treated-with-immune-checkpoint-inhibitors
#21
R Fayos Gregori, C Labrandero Hoyos, R Peñuelas Leal, V Alegre de Miquel
No abstract text is available yet for this article.
September 13, 2022: Actas Dermo-sifiliográficas
https://read.qxmd.com/read/35766728/concurrence-between-guillain-barr%C3%A3-syndrome-and-immune-thrombocytopenic-purpura-possibly-induced-by-long-covid-19
#22
Rafael Pichardo-Rodríguez, Juan-Jesús Bracamonte-Hernández, Diana-Cristina Ramírez-Meyhuay, Ingrid-Roxani Arquinigo-Lavado, Willy Peña-Oscuvilca, Marcos Saavedra-Velasco, Oscar Ruiz-Franco
During acute SARS-CoV-2 infection, there is persistent deregulation of the immune system that can last up to 8 months after the acute condition is controlled. This, added to other factors, is possibly associated with an increased risk of the appearance and concurrence of autoimmune diseases. The simultaneous occurrence of GBS and ITP has been rarely reported in the literature, and GBS is rarely associated with another autoimmune disease. We present the case of a man who, one month after his recovery from acute moderate COVID-19, presented concurrent GBS and ITP with an adequate response to treatment...
January 2022: Revista Peruana de Medicina Experimental y Salud Pública
https://read.qxmd.com/read/35636961/colorectal-cancer-immune-response-in-laparoscopic-versus-open-colorectal-surgery
#23
JOURNAL ARTICLE
Ana B Martínez-Martínez, Jose M Arbonés-Mainar
INTRODUCTION: Colorectal cancer is the second most frequent cause of deaths from cancer worldwide. Enhanced recovery protocols (ERPs) were developed in 90s to improve the recovery of these patients. Within ERPs, this work aims to compare immune response between open and laparoscopic procedures to support the best surgical approach. MATERIALS AND METHODS: The immune status of 148 patients undergoing colorectal surgery (74 by laparoscopic and 74 by open surgery [OS]) was studied in three moments: before surgery (POD0) and on the 1st and 3th post-operative days (POD1 and POD3)...
2022: Cirugia y Cirujanos
https://read.qxmd.com/read/35349562/distribution-of-peripheral-blood-cells-after-splenectomy-in-immune-thrombocytopenia-patients
#24
JOURNAL ARTICLE
Arife Simsek
BACKGROUND: There are some difficulties regarding the evaluation of the post-splenectomy state. OBJECTIVE: The objective of the study is to compare the post-splenectomy blood changes of immune thrombocytopenia (ITP) patients with those of trauma patients, 1 month and ≥ 6 months after surgery. METHODS: Medical records of patients, who had undergone total splenectomy for ITP and trauma at a tertiary center between January 2009 and December 2019, were retrospectively reviewed...
2022: Cirugia y Cirujanos
https://read.qxmd.com/read/35332889/biomarkers-for-characterization-and-therapeutic-orientation-in-castration-resistant-prostate-cancer
#25
JOURNAL ARTICLE
Ana Plata Bello, Marco Antonio Tamayo Jover, Fernando Gutierrez Nicolas, Silvia Acosta López, Tomás Concepción Masip, Julio Plata Bello
Whole exome sequencing studies haverevealed the molecular landscape of metastatic CastrateResistant Prostate Cancer (mCRPC) providingnew information about prognostic and predictive factorsof response to therapies. These studies highlightedpotentially actionable targets leading to the beginingof the biomarker-driven era in prostate cancer.Alterations in androgen receptor (AR), DNA repair genes,PI3K-AKT-MTOR pathway or in genes involved incell cycle are frequently observed in mCRPC patientsand may be relevant in the resistance induced mechanismto approve therapy in this setting...
March 2022: Archivos Españoles de Urología
https://read.qxmd.com/read/34872742/inmune-mediated-inflammatory-rheumatic-diseases-in-transgender-people-a-scoping-review
#26
REVIEW
Eva Salgado, Montserrat Romera-Baurés, Emma Beltran-Catalan, Esperanza Naredo, Patricia E Carreira, Mariluz Garcia-Vivar, Jose V Moreno-Muelas, Alina Boteanu, Inma Calvo-Penades, Agusti Sellas-Fernandez, Marta Valero, Juan J Gomez-Reino
BACKGROUND: In immune-mediated inflammatory rheumatic diseases (IMIRD), there are differences between cis-men and cis-women in epidemiology, clinical feature, therapeutic approach, treatment response, and prognosis. In transgender individuals, information concerning IMIRD is not substantial. The assessment of information concerning rheumatic diseases in transgenders is crucial because transgenders may undergo treatments with potential impacts on IMIRD. We aim to collect and discuss current knowledge on IMIRD in transgender individuals, determine the coverage of the literature, identify the knowledge gaps, and highlight opportunities for future research...
February 2022: Seminars in Arthritis and Rheumatism
https://read.qxmd.com/read/34866030/pericardial-and-myocardial-involvement-after-sars-cov-2-infection-a-cross-sectional-descriptive-study-in-healthcare-workers
#27
JOURNAL ARTICLE
Rocío Eiros, Manuel Barreiro-Pérez, Ana Martín-García, Julia Almeida, Eduardo Villacorta, Alba Pérez-Pons, Soraya Merchán, Alba Torres-Valle, Clara Sánchez-Pablo, David González-Calle, Oihane Pérez-Escurza, Inés Toranzo, Elena Díaz-Peláez, Blanca Fuentes-Herrero, Laura Macías-Álvarez, Guillermo Oliva-Ariza, Quentin Lecrevisse, Rafael Fluxa, José L Bravo-Grande, Alberto Orfao, Pedro L Sánchez
INTRODUCTION AND OBJECTIVES: The cardiac sequelae of SARS-CoV-2 infection are still poorly documented. We conducted a cross-sectional study in healthcare workers to report evidence of pericardial and myocardial involvement after SARS-CoV-2 infection. METHODS: We studied 139 healthcare workers with confirmed past SARS-CoV-2 infection. Participants underwent clinical assessment, electrocardiography, and laboratory tests, including immune cell profiling and cardiac magnetic resonance (CMR)...
November 5, 2021: Revista Española de Cardiología
https://read.qxmd.com/read/34844781/-immunosenescence-viral-infections-and-nutrition-a-narrative-review-of-scientific-available-evidence
#28
REVIEW
Mariane Lutz, Marcelo Arancibia, Cristian Papuzinski, Jana Stojanova
Aging of the immune system, or immunosenescence, alters the viral immune response in the elderly, especially when frailty exists. Research findings have demonstrated an imbalance in pro- and anti-inflammatory mechanisms, reduced production and diversification of T lymphocytes, and an alteration in immunovigilance and antibody synthesis. In this context, nutrition has a role in combating sarcopenia and frailty. Some food components that contribute to immune-competence are protein, vitamin D, n-3 fatty acids, antioxidant vitamins (vitamins C and E), zinc, selenium and iron...
January 2022: Revista Española de Geriatría y Gerontología
https://read.qxmd.com/read/34841388/long-term-analysis-of-antibodies-elicited-by-sputnik-v-a-prospective-cohort-study-in-tucum%C3%A3-n-argentina
#29
JOURNAL ARTICLE
Rossana Elena Chahla, Rodrigo Hernán Tomas-Grau, Silvia Inés Cazorla, Diego Ploper, Esteban Vera Pingitore, Mónica Aguilar López, Patricia Aznar, María Elena Alcorta, Eva María Del Mar Vélez, Agustín Stagnetto, César Luís Ávila, Carolina Maldonado-Galdeano, Sergio Benjamín Socias, Dar Heinze, Silvia Adriana Navarro, Conrado Juan Llapur, Dardo Costa, Isolina Flores, Alexis Edelstein, Shreyas Kowdle, Claudia Perandones, Benhur Lee, Gabriela Apfelbaum, Raúl Mostoslavsky, Gustavo Mostoslavsky, Gabriela Perdigón, Rosana Nieves Chehín
BACKGROUND: Gam-COVID-Vac (SPUTNIK V) has been granted emergency use authorization in 70 nations and has been administered to millions worldwide. However, there are very few peer-reviewed studies describing its effects. Independent reports regarding safety and effectiveness could accelerate the final approval by the WHO. We aimed to study the long-term humoral immune response in naïve and previously infected volunteers who received SPUTNIK V. METHODS: Humoral immune responses, assayed by anti-SARS-CoV-2-spike-RBD IgG ELISA and neutralization assays, were measured in 602 healthcare workers at 0, 14, 28, 60 and 180 days after receiving SPUTNIK V between December 2020 and July 2021 in Tucumán, Argentina...
February 2022: Lancet Reg Health Am
https://read.qxmd.com/read/34352870/hemorrhagic-stroke-associated-to-covid-19-infection-in-mexico-general-hospital
#30
JOURNAL ARTICLE
Gustavo Parra-Romero, Ariatne Mar-Álvarez, José L Navarro-Olvera, Aldo F Hernández-Valencia, Gustavo Aguado-Carrillo, José D Carrillo-Ruiz
INTRODUCCIÓN: en la actual pandemia de COVID-19, existe evidencia creciente que ha identificado el neurotropismo del virus SARS-CoV-2 y sus complicaciones neurológicas, incluida la enfermedad cerebrovascular isquémica y escasamente hemorragia cerebral (HC). OBJETIVO: describir las características clínicas, radiológicas, de laboratorio y pronósticas de los pacientes con HC asociada al SARS-CoV-2. MÉTODOS: se incluyeron pacientes consecutivos con prueba de PCR confirmatoria para infección por SARS-CoV-2 y HC...
2021: Cirugia y Cirujanos
https://read.qxmd.com/read/34309308/neonatal-thrombocytopenia-a-review-ii-non-immune-thrombocytopenia-platelet-transfusion
#31
REVIEW
Hugo Donato
Non-immune thrombocytopenia is caused by multiple pathologies; the most common causes are extra- or intrauterine infections, whereas secondary cases result from other pathologies involved in the fetal-placentalmaternal interface. This second article lists its causes and provides details of the different pathologies. Platelet transfusion is widely used in neonatology, both as treatment and as bleeding prophylaxis. However, there is no general consensus about the platelet count threshold that is convenient to indicate a transfusion or actual indications...
August 2021: Archivos Argentinos de Pediatría
https://read.qxmd.com/read/34286816/the-excellent-biocompatibility-and-negligible-immune-response-of-the-titanium-heterometallic-mof-muv-10
#32
JOURNAL ARTICLE
Isabel Abánades Lázaro, Jose M Rodrigo-Muñoz, Beatriz Sastre, María Romero Ángel, Carlos Martí-Gastaldo, Victoria Del Pozo
The Ti-Ca heterometallic MOF MUV-10 exhibits good dispersibility in phosphate buffer and low phosphate-induced degradation in comparison to other MOF systems. It induces no cytotoxicity towards cells of the immune system and no inmune response, making it an attractive candidate for biomedical applications and demonstrating its safe use for other applications.
July 20, 2021: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://read.qxmd.com/read/34272191/interleukin-17a-potential-mediator-and-therapeutic-target-in-hypertension
#33
REVIEW
Raúl R Rodrigues-Diez, Antonio Tejera-Muñoz, Macarena Orejudo, Laura Marquez-Exposito, Laura Santos-Sanchez, Sandra Rayego-Mateos, Elena Cantero-Navarro, Lucia Tejedor-Santamaria, Vanessa Marchant, Alberto Ortiz, Jesús Egido, Sergio Mezzano, Rafael Selgas, Juan F Navarro-González, Jose M Valdivielso, Carolina Lavoz, Marta Ruiz-Ortega
Interleukin-17A (IL-17A) is a proinflammatory cytokine produced by cells of the immune system, predominantly Th17 and γδ lymphocytes. In this paper, we review the role of IL-17A in the pathogenesis of hypertension and in target organ damage. Preclinical studies in mice have shown that systemic adminstration of IL-17A increases blood pressure, probably by acting on multiple levels. Furthermore, IL-17A plasma concentrations are already elevated in patients with mild or moderate hypertension. Many studies in hypertensive mice models have detected IL-17A-producing cells in target organs such as the heart, vessels and kidneys...
July 13, 2021: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://read.qxmd.com/read/34259229/-public-funding-impact-of-the-pneumococcal-vaccine-on-compliance-with-the-vaccination-schedule
#34
JOURNAL ARTICLE
Abelardo Fernández Chávez, María Dolores Lasheras Carbajo, Luis García Comas, Guillermo Ordoñez León, Jesús María Aranaz Andrés
OBJECTIVE: It is important to know the impact of public financing on routine vaccination on compliance with the vaccination regimen. Few studies have been carried out on this topic. The objective of this study was to describe the effect of public financing of pneumococcal vaccine on vaccination coverage and the degree of compliance with the vaccination regimen in the child population of the Community of Madrid (CM). METHODS: A descriptive observational study was carried out...
July 14, 2021: Revista Española de Salud Pública
https://read.qxmd.com/read/34246622/management-of-primary-immune-thrombocytopenia-a-comparison-between-two-historical-cohorts
#35
JOURNAL ARTICLE
Sandra Fernández-Plaza, Jesús González de Pablo, Eva Gálvez, Josune Zubicaray, Julián Sevilla, Elena Sebastián
INTRODUCTION: In recent years, there have been changes in the management of patients with primary immune thrombocytopenia. In this study, a review is presented of the characteristics and outcomes of children with primary immune thrombocytopenia in a children's hospital (Hospital Infantil Niño Jesús). Moreover, an analysis is made of the changes in the care of these patients diagnosed before and after 2011, when new guidelines were published by the Spanish Society of Paediatric Haematology Oncology (SEHOP)...
August 2021: Anales de pediatría
https://read.qxmd.com/read/34170987/-is-the-immune-hyporesponsiveness-of-uremic-patients-a-protective-factor-for-severe-covid-19-pneumonia
#36
JOURNAL ARTICLE
Enrique A Florit, Fritz Diekmann
No abstract text is available yet for this article.
March 2021: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://read.qxmd.com/read/34088525/guidelines-of-the-spanish-itp-group-for-the-diagnosis-treatment-and-follow-up-of-patients-with-immune-thrombopenia
#37
JOURNAL ARTICLE
María L Lozano, Miguel A Sanz, Vicente Vicente
No abstract text is available yet for this article.
August 27, 2021: Medicina Clínica
https://read.qxmd.com/read/34088435/diagnostic-efficiency-of-systemic-immune-inflammation-index-in-fusion-prostate-biopsy
#38
JOURNAL ARTICLE
G Sonmez, T Demirtas, S T Tombul, H Akgun, A Demirtas
OBJECTIVE: To investigate the diagnostic efficiency of systemic immune response (SII) in prostate cancer (PCa) in patients with PSA < 10 ng/mL undergoing fusion prostate biopsy. METHODS: The prospective study included patients who were planned for fusion prostate biopsy and had PSA < 10 ng/mL and a PI-RADS ≥ 3. All the patients underwent 12-core standard transrectal prostate biopsy followed targeted biopsy (combined biopsy). Based on preoperative complete blood count parameters, SII was calculated using the following formula: SII = platelet × neutrophil-to-lymphocyte ratio...
June 2021: Actas urologicas españolas
https://read.qxmd.com/read/34075268/-role-of-the-immune-system-in-sars-cov-2-infection-immunopathology-of-covid-19
#39
JOURNAL ARTICLE
J Monserrat Sanz, A M Gómez Lahoz, R Oliva Martín
The immune system is capable of adequately controlling SARS-CoV-2 infection in 81% of patients, whose disease is asymptomatic or who experience moderate symptoms. However, 19% of infected patients develop severe disease which can become critical or fatal. This review article intends to provide an overview of the epidemiological antecedents of β-coronaviruses, describe the mechanisms of SARS-CoV-2 infection, and summarize the rational immunological underpinnings known at present which allow for a better understanding of the immunopathology of COVID-19...
May 2021: Medicine
https://read.qxmd.com/read/34037616/acute-portal-vein-thrombosis-in-mild-cholecystitis-a-consequence-of-coronavirus-disease-2019-infection
#40
JOURNAL ARTICLE
Daniel Rivera-Alonso, Inés Rivera-Alonso, Mauricio Burneo-Esteves, Carlos Martínez-Ruíz, Mikel Rojo-Abecia, Carlos Moreno-Sanguino
La infección por el virus SARS-CoV-2 provoca, además de cuadros respiratorios graves, episodios trombóticos en múltiples localizaciones debido a una mala regulación de la respuesta inmune. Presentamos el caso de un paciente con colecistitis incipiente que desarrolló trombosis portal aguda sin ningún otro antecedente salvo haber pasado de forma asintomática una infección por COVID-19. Dado que esta complicación es extremadamente infrecuente en pacientes sin factores predisponentes ni infecciones graves, consideramos que la infección por COVID-19 pudo ser un factor desencadenante de la trombosis portal y debemos de tenerlo en cuenta de cara al manejo y tratamiento de futuros casos similares...
2021: Cirugia y Cirujanos
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