Rossana Elena Chahla, Rodrigo Hernán Tomas-Grau, Silvia Inés Cazorla, Diego Ploper, Esteban Vera Pingitore, Mónica Aguilar López, Patricia Aznar, María Elena Alcorta, Eva María Del Mar Vélez, Agustín Stagnetto, César Luís Ávila, Carolina Maldonado-Galdeano, Sergio Benjamín Socias, Dar Heinze, Silvia Adriana Navarro, Conrado Juan Llapur, Dardo Costa, Isolina Flores, Alexis Edelstein, Shreyas Kowdle, Claudia Perandones, Benhur Lee, Gabriela Apfelbaum, Raúl Mostoslavsky, Gustavo Mostoslavsky, Gabriela Perdigón, Rosana Nieves Chehín
BACKGROUND: Gam-COVID-Vac (SPUTNIK V) has been granted emergency use authorization in 70 nations and has been administered to millions worldwide. However, there are very few peer-reviewed studies describing its effects. Independent reports regarding safety and effectiveness could accelerate the final approval by the WHO. We aimed to study the long-term humoral immune response in naïve and previously infected volunteers who received SPUTNIK V. METHODS: Humoral immune responses, assayed by anti-SARS-CoV-2-spike-RBD IgG ELISA and neutralization assays, were measured in 602 healthcare workers at 0, 14, 28, 60 and 180 days after receiving SPUTNIK V between December 2020 and July 2021 in Tucumán, Argentina...
February 2022: Lancet Reg Health Am