keyword
https://read.qxmd.com/read/38383267/immune-thrombocytopenia-in-systemic-lupus-erythematosus-prevalence-risk-factors-and-a-novel-predictive-model-for-risk-assessment
#1
JOURNAL ARTICLE
Jesús Cornudella Lema, Blanca Sánchez-González, Irene Carrión-Barberà, Sergio Vázquez Montes de Oca, Francesc García Pallarols, Tarek Carlos Salman-Monte
INTRODUCTION: Immune thrombocytopenia (ITP) is a potentially severe manifestation of systemic lupus erythematosus (SLE) reported in 7-40% of SLE patients. ITP has been associated with a higher risk of organ damage and mortality. OBJECTIVES: To describe which factors are associated with the presence of ITP in SLE patients. METHODS: Retrospective case-control study. Cases were defined as SLE patients who had ever developed ITP and were sex- and age-matched with two controls...
February 20, 2024: Medicina Clínica
https://read.qxmd.com/read/38143232/the-mva-vector-expressing-the-f-protein-of-bovine-respiratory-syncytial-virus-is-immunogenic-in-systemic-and-mucosal-immunization-routes
#2
JOURNAL ARTICLE
Alejandra Ferella, Marina Mozgovoj, Débora Garanzini, María José Dus Santos, Gabriela Calamante, María Paula Del Médico Zajac
Bovine respiratory syncytial virus (BRSV) affects both beef and dairy cattle, reaching morbidity and mortality rates of 60-80% and 20%, respectively. The aim of this study was to obtain a recombinant MVA expressing the BRSV F protein (MVA-F) as a vaccine against BRSV and to evaluate the immune response induced by MVA-F after systemic immunization in homologous and heterologous vaccination (MVA-F alone or combined with a subunit vaccine), and after intranasal immunization of mice. MVA-F administered by intraperitoneal route in a homologous scheme elicited levels of neutralizing antibodies similar to those obtained with inactivated BRSV as well as better levels of IFN-γ secretion...
December 23, 2023: Revista Argentina de Microbiología
https://read.qxmd.com/read/38117982/sars-cov-2-humoral-immune-response-in-patients-with-cardiovascular-risk-factors-the-community-cohort-study
#3
JOURNAL ARTICLE
Vivienne C Bachelet, Ignacio Silva-Ayarza, María S Navarrete
Based on the recommendations of the Vaccine Advisory Committee and the National Immunization Program, Chile implemented an early vaccination process of the population with vaccines from different laboratories. The study of neutralizing antibody levels in different population subgroups contributes to the establishment of correlates of protection against SARS-CoV-2 infection. In 2022 and 2023 we set up a community cohort of 914 adults with cardiovascular risk factors. In this cohort we are measuring the humoral immune response to exposure to SARS-CoV-2 antigens, either by vaccines or infection, as well as the incidence of COVID-19 and other adverse events...
December 20, 2023: Medwave
https://read.qxmd.com/read/38060951/-not-available
#4
JOURNAL ARTICLE
Norma Mongua-Rodríguez, Guadalupe Delgado-Sánchez, Elizabeth Ferreira-Guerrero, Leticia Ferreyra-Reyes, Maribel Martínez-Hernández, Sergio Canizales-Quintero, Norma Aracely Téllez-Vázquez, Lourdes García-García
OBJETIVO: Describir las coberturas de vacunación en 2022 en niñas, niños y en adolescentes, así como comparar las prevalencias observadas con los datos de la Encuesta Nacional de Salud y Nutrición 2021 (Ensanut 2021). Material y métodos. Análisis de datos obtenidos de la Ensanut 2022. RESULTADOS: En los niños menores de cinco años, las coberturas de vacuna con Bacilo de Calmette y Guérin (BCG), hepatitis B, pentavalente o hexavalente, neumocócica, antirotavirus y triple viral (SRP) fueron de 78...
June 15, 2023: Salud Pública de México
https://read.qxmd.com/read/38000944/adverse-renal-effects-of-check-point-inhibitors-ici-in-cancer-patients-recommendations-of-the-onco-nephrology-working-group-of-the-spanish-society-of-nephrology
#5
JOURNAL ARTICLE
Fabiola Alonso, Ángel L M Martín de Francisco, Pilar Auñón, Clara García-Carro, Patricia García, Eduardo Gutiérrez, Manuel Mcía, Luis F Quintana, Borja Quiroga, María José Soler, Isidro Torregrosa
The most widely used approach in the immunotherapy treatment of cancer is the administration of monoclonal antibodies directed against regulatory molecules of immune control that inhibit the activation of T cells, the so-called check point inhibitors (ICI). ICI nephrotoxicity epidemiology and pathology; its diagnosis with or without kidney biopsy; the type and duration of treatment; the possibility of rechallenging after kidney damage; and its indication in patients with cancer and renal transplantation are certainly controversial...
2023: Nefrología
https://read.qxmd.com/read/37933923/-sistema-inmune-innato-e-infecci%C3%A3-n-por-sars-cov-2-revisi%C3%A3-n-sistem%C3%A3-tica
#6
JOURNAL ARTICLE
Elda María Del Rocío Coutiño-Rodríguez
In the face of SARS-CoV-2 infection, an uncontrolled and unregulated response of the innate immune system can cause local and multisystem organ damage, which is characteristic of patients admitted to hospitals and who die from this virus. See some of the factors involved in the severe pathological pictures of this infection, mainly in men, in articles published between 2010 and 2021 and specialized books. Research shows that age, gender, race, and blood group (specifically A), coupled with factors such as immunosenescence and comorbidities, are crucial in the severity of the disease...
September 2023: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://read.qxmd.com/read/37485845/hiv-protease-inhibitor-saquinavir-inhibits-toll-like-receptor-4-activation-by-targeting-receptor-dimerization
#7
JOURNAL ARTICLE
Kai Yao, Zheng Wang, Cheng Peng, Yong Wang, Bichen Xue, Yulin Tang, Zhichao Wang, Hongbo Xu
Toll like receptor 4 (TLR4) is crucial in induction of innate immune response through recognition of invading pathogens or endogenous alarming molecules. Ligand-triggered dimerization of TLR4 is essential for the activation of NF-kB and IRF3 through MyD88- or TRIF-dependent pathways. Saquinavir (SQV), a FDA-approved HIV protease inhibitor, has been shown to attenuate the activation of NF-kB induced by HMGB1 by blocking TLR4-MyD88 association in proteasome-independent pathway. However, it remains unknown whether SQV is a HMGB1-specific and MyD88-dependent TLR4 signaling inhibitor and which precise signaling element of TLR4 is targeted by SQV...
July 24, 2023: Immunopharmacology and Immunotoxicology
https://read.qxmd.com/read/37453544/-translated-article-rf-can-targeted-therapy-be-combined-with-immunotherapy-for-melanoma
#8
JOURNAL ARTICLE
N Mohino, A Boada
No abstract text is available yet for this article.
July 13, 2023: Actas Dermo-sifiliográficas
https://read.qxmd.com/read/37382551/spondyloenchondrodysplasia-with-immune-dysregulation-related-to-acp5-a-report-of-4-cases
#9
JOURNAL ARTICLE
Jimena Dri, Eugenia Dos Santos, Marcela Pereyra, María J Guillamondegui, Celeste Ballester, Ana Tolin, Cristina Gatica
Spondyloenchondrodysplasia with immune dysregulation related to ACP5 (SPENCDI, OMIM number 607944) is an uncommon immune-skeletal dysplasia with heterogeneous manifestations and variable severity. It is characterized by spondylar and metaphyseal lesions, immune dysfunction, and neurological involvement. Here we report the clinical, radiological and genetic aspects of 4 girls with SPENCDI treated at a children's hospital. They all had skeletal manifestations and 3 developed severe immune disease. In 3 patients, the likely pathogenic variant c...
July 6, 2023: Archivos Argentinos de Pediatría
https://read.qxmd.com/read/37313341/an-mva-based-vector-expressing-cell-free-isg15-increases-ifn-i-production-and-improves-hiv-1-specific-cd8-t-cell-immune-responses
#10
JOURNAL ARTICLE
Michela Falqui, Beatriz Perdiguero, Rocio Coloma, Manuel Albert, Laura Marcos-Villar, Joseph Patrick McGrail, Carlos Óscar S Sorzano, Mariano Esteban, Carmen Elena Gómez, Susana Guerra
The human immunodeficiency virus (HIV), responsible of the Acquired Immune Deficiency Syndrome (AIDS), continues to be a major global public health issue with any cure or vaccine available. The Interferon-stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that is induced by interferons and plays a critical role in the immune response. ISG15 is a modifier protein that covalently binds to its targets via a reversible bond, a process known as ISGylation, which is the best-characterized activity of this protein to date...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/37150249/can-targeted-therapy-be-combined-with-immunotherapy-for-melanoma
#11
JOURNAL ARTICLE
N Mohino, A Boada
No abstract text is available yet for this article.
May 5, 2023: Actas Dermo-sifiliográficas
https://read.qxmd.com/read/37084305/importance-of-the-sars-cov-2-genome-and-spike-protein-in-the-immunopathogenesis-of-covid-19-and-in-the-efficacy-of-vaccines
#12
REVIEW
Silvia Jiménez-Morales, Carlos J Pérez-Amado, Isela Montúfar-Robles, José M Fragoso, Iván S Aranda-Uribe, David A Ramos-Puga, Ángel E Martínez-Flores, Julián Ramírez-Bello
Coronavirus (CoV) infections cause respiratory and enteric diseases with clinical manifestations ranging from faint to severe, even lead to death of patients. High connectivity between nations and infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represent a global health problem as the coronavirus disease 19 (COVID-19). This CoV-2 that cause SARS, which appeared in Wuhan, China, in December 2019 originated COVID-19 and declared as pandemic a few months posterior its appearance. In this review, the genomic and spike protein characteristics of SARS-CoV-2, the role of SARS-CoV-2 in the COVID-19 pathogenesis, cytokine storm, the role of cytotoxic T and B cells against SARS-CoV-2, as well as the vaccines efficacy (taking into account mutations in the spike protein) are described...
2023: Cirugia y Cirujanos
https://read.qxmd.com/read/36761900/photodynamic-nasal-sars-cov-2-decolonization-shortens-infectivity-and-influences-specific-t-cell-responses
#13
RANDOMIZED CONTROLLED TRIAL
Alejandro Fernandez-Montero, Jon Zuaznabar, Manuel Pina-Sanchez, Sheila Maestro, Loreto Martin-Navarro, Natalia Muñoz-Rodríguez, Cristina Olagüe, Marta Pastrana, Maria Martínez-Fernández, Gracian Camps, Jose Antonio Rodriguez, Francesco P Marchese, Jon Zazpe, Marta Pozuelo, José Luis Del Pozo, Jorge Quiroga, Antonio Pineda-Lucena, Gabriel Reina, Jack Kolenda, Laura Moreno-Galarraga, Gloria Gonzalez-Aseguinolaza, Marta Rua, Cristian Smerdou, Francisco Carmona-Torre, Josepmaria Argemi
BACKGROUND: The main objective was to evaluate the efficacy of intranasal photodynamic therapy (PDT) in SARS-CoV-2 mildly symptomatic carriers on decreasing the infectivity period. SARS-CoV-2-specific immune-stimulating effects and safety were also analysed. METHODS: We performed a randomized, placebo-controlled, clinical trial in a tertiary hospital (NCT05184205). Patients with a positive SARS-CoV-2 PCR in the last 48 hours were recruited and aleatorily assigned to PDT or placebo...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/36756916/immune-thrombotic-thrombocytopenic-purpura-clinical-suspicion-and-basic-management-in-emergency-departments-an-expert-review-and-consensus-statement-from-the-spanish-societies-of-hematology-and-hemotherapy-sehh-and-emergency-medicine-semes
#14
JOURNAL ARTICLE
Cristina Pascual-Izquierdo, Pascual Piñera Salmerón, Francisco Temboury Ruiz, David Valcárcel Ferreiras, Sonia Jiménez Hernández, Ramón Salinas Argente, Carmen Del Arco Galán, Javier de la Rubia Comos
Acquired or immune thrombotic thrombocytopenic purpura (TTP) are thrombotic microangiopathies associated with high mortality if treatment is not started early. Onset is usually sudden, meaning that the condition is often diagnosed in hospital emergency departments, where TTP must be suspected as early as possible. These guidelines were drafted by specialists in emergency medicine and hematology to cover the diagnosis, referral, and treatment of patients suspected of immune-mediated TTP who require emergency care...
February 2023: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
https://read.qxmd.com/read/36737385/the-presence-of-activating-igg-fc-receptors-in-macrophages-aggravates-the-development-of-experimental-abdominal-aortic-aneurysm
#15
JOURNAL ARTICLE
Laura López-Sanz, Susana Bernal, Luna Jiménez-Castilla, Marisa Pardines, Ana Hernández-García, Luis Blanco-Colio, José Luis Martín-Ventura, Carmen Gómez Guerrero
INTRODUCTION: Abdominal aortic aneurysm (AAA) is a multifactorial, degenerative disease characterized by progressive aortic dilation and chronic activation of inflammation, proteolytic activity, and oxidative stress in the aortic wall. The immune response triggered by antibodies against antigens present in the vascular wall participates in the formation and progression of AAA through mechanisms not completely understood. This work analyses the function of specific IgG receptors (FcγR), especially those expressed by monocytes/macrophages, in the development of experimental AAA...
February 1, 2023: Clínica e Investigación en Arteriosclerosis
https://read.qxmd.com/read/36690146/-translated-article-adverse-dermatologic-reactions-in-patients-treated-with-immune-checkpoint-inhibitors
#16
R Fayos Gregori, C Labrandero Hoyos, R Peñuelas Leal, V Alegre de Miquel
No abstract text is available yet for this article.
March 2023: Actas Dermo-sifiliográficas
https://read.qxmd.com/read/36542424/-clinical-evolution-of-31-adult-patients-with-immune-thrombocytopenia-treated-with-rituximab
#17
JOURNAL ARTICLE
Guillermo Rodolfo Gutiérrez-Espíndola, Jesús Medrano-Contreras, Dafne Itzel Campa-Monroy, Elizabeth Sabbagh-Sánchez, Raúl Martínez-Castro
BACKGROUND: Primary immune thrombocytopenia (ITP) is an autoimmune disease that could cause different grades of bleeding, which could even threat the patients' life or make them experience poor quality of life. ITP can be treated with rituximab either as a first or second-line therapy option, resulting in an overall response of 60%. The best results have been observed on young women with a short time of disease evolution. OBJECTIVE: To report the response and clinical evolution by providing therapy with rituximab, which was used as a rescue in adult patients with either persistent or chronical ITP...
January 2, 2023: Revista Médica del Instituto Mexicano del Seguro Social
https://read.qxmd.com/read/36511678/-relaci%C3%A3-n-microbiota-intestinal-y-%C3%A3-cidos-grasos-de-cadena-corta-en-pacientes-cr%C3%A3-ticos-con-sepsis-durante-su-estancia-en-la-unidad-de-cuidados-intensivos
#18
JOURNAL ARTICLE
Luz Dary Vásquez-Guarín, Victoria Mesa, Beatriz Valdés-Duque, Gloria María Agudelo-Ochoa, Adriana Giraldo-Villa, Irene Acevedo-Castano, Nubia Amparo Giraldo-Giraldo
Introducción. El paciente crítico séptico presenta alteraciones en la microbiota intestinal que puede afectar la producción de ácidos grasos de cadena corta y condicionar su respuesta inmune e inflamatoria. Objetivo. Determinar la relación entre la microbiota intestinal y la concentración de ácidos grasos de cadena corta en pacientes críticos sépticos. Materiales y métodos. Estudio observacional descriptivo. Incluyó 15 pacientes críticos sépticos con una muestra de heces para microbiota intestinal y otra para ácidos grasos de cadena corta del mismo día o con uno de diferencia...
August 22, 2022: Biomédica: Revista del Instituto Nacional de Salud
https://read.qxmd.com/read/36403875/transcriptomic-and-metabolomic-integration-to-assess-the-response-of-gilthead-sea-bream-sparus-aurata-exposed-to-the-most-used-insect-repellent-deet
#19
JOURNAL ARTICLE
Nieves R Colás-Ruiz, Frédérique Courant, Elena Gomez, Pablo A Lara-Martín, Miriam Hampel
DEET is one of the most frequently detected insect repellents in the environment reaching concentrations of several μg L-1 in surface water. There is scarce information available regarding its mode of action in non-target organisms. Here, we have used an integrated metabolomic and transcriptomic approach to elucidate the possible adverse effects of DEET exposure in the marine fish gilthead sea bream (Sparus aurata). Individuals were exposed at an environmentally relevant concentration of DEET (10 μg L-1 ) for 22 days in a continuous flow-through system...
November 17, 2022: Environmental Pollution
https://read.qxmd.com/read/36172732/-application-of-immune-checkpoint-inhibitors-in-egfr-mutant-advanced-non-small-cell-lung-cancer
#20
JOURNAL ARTICLE
Yujun Zheng, Wei Jiang, Jing Li, Lulu Dai, Dongyan Chen, Yanjun Li, Lei Huang, Mingji Wang
In recent years, immune checkpoint inhibitors (ICIs) have greatly improved the survival rate of non-small cell lung cancer (NSCLC) patients without driver mutation. Compared with wild-type tumors, tumors with epidermal growth factor receptor (EGFR) mutations have greater heterogeneity in immune microenvironment characteristics such as programmed cell death ligand 1 (PD-L1) and tumor mutational burden (TMB). Whether ICIs is suitable for NSCLC patients with EGFR mutation has been controversial. Clinical studies have shown that immunomonotherapy has no significant effect on patients with EGFR mutant NSCLC...
September 20, 2022: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
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