Alejandro Fernandez-Montero, Jon Zuaznabar, Manuel Pina-Sanchez, Sheila Maestro, Loreto Martin-Navarro, Natalia Muñoz-Rodríguez, Cristina Olagüe, Marta Pastrana, Maria Martínez-Fernández, Gracian Camps, Jose Antonio Rodriguez, Francesco P Marchese, Jon Zazpe, Marta Pozuelo, José Luis Del Pozo, Jorge Quiroga, Antonio Pineda-Lucena, Gabriel Reina, Jack Kolenda, Laura Moreno-Galarraga, Gloria Gonzalez-Aseguinolaza, Marta Rua, Cristian Smerdou, Francisco Carmona-Torre, Josepmaria Argemi
BACKGROUND: The main objective was to evaluate the efficacy of intranasal photodynamic therapy (PDT) in SARS-CoV-2 mildly symptomatic carriers on decreasing the infectivity period. SARS-CoV-2-specific immune-stimulating effects and safety were also analysed. METHODS: We performed a randomized, placebo-controlled, clinical trial in a tertiary hospital (NCT05184205). Patients with a positive SARS-CoV-2 PCR in the last 48 hours were recruited and aleatorily assigned to PDT or placebo...
2023: Frontiers in Cellular and Infection Microbiology