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https://www.readbyqxmd.com/read/28716046/blood-volume-monitored-regulation-of-ultrafiltration-to-decrease-the-dry-weight-in-fluid-overloaded-hemodialysis-patients-a-randomized-controlled-trial
#1
Marlies Antlanger, Peter Josten, Michael Kammer, Isabella Exner, Katharina Lorenz-Turnheim, Manfred Eigner, Gernot Paul, Renate Klauser-Braun, Gere Sunder-Plassmann, Marcus D Säemann, Manfred Hecking
BACKGROUND: Because chronic fluid volume overload is associated with higher mortality, we tested whether blood-volume monitored regulation of ultrafiltration and dialysate conductivity (UCR) and/or regulation of ultrafiltration and temperature (UTR) would facilitate dry weight reduction, in comparison to conventional dialysis (CONV). METHODS: We carried out a multicenter, 4-week, randomized controlled trial in hemodialysis patients ≥15% above normal extracellular fluid volume (ECV), per bioimpedance spectroscopy, who were randomized 1:1:1...
July 17, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28692703/physical-examination-skills-training-faculty-staff-vs-patient-instructor-feedback-a-controlled-trial
#2
Markus Krautter, Katja Diefenbacher, Jobst-Hendrik Schultz, Imad Maatouk, Anne Herrmann-Werner, Nadja Koehl-Hackert, Wolfgang Herzog, Christoph Nikendei
BACKGROUND: Standardized patients are widely used in training of medical students, both in teaching and assessment. They also frequently lead complete training sessions delivering physical examination skills without the aid of faculty teaching staff-acting as "patient instructors" (PIs). An important part of this training is their ability to provide detailed structured feedback to students which has a strong impact on their learning success. Yet, to date no study has assessed the quality of physical examination related feedback by PIs...
2017: PloS One
https://www.readbyqxmd.com/read/28586713/a-randomized-controlled-trial-of-internet-based-cognitive-behavior-therapy-for-perfectionism-including-an-investigation-of-outcome-predictors
#3
Alexander Rozental, Roz Shafran, Tracey Wade, Sarah Egan, Lise Bergman Nordgren, Per Carlbring, Andreas Landström, Stina Roos, Malin Skoglund, Elisabet Thelander, Linnéa Trosell, Alexander Örtenholm, Gerhard Andersson
Being highly attentive to details can be a positive feature. However, for some individuals, perfectionism can lead to distress and is associated with many psychiatric disorders. Cognitive behavior therapy has been shown to yield many benefits for those experiencing problems with perfectionism, but the access to evidence-based care is limited. The current study investigated the efficacy of guided Internet-based Cognitive Behavior Therapy (ICBT) and predictors of treatment outcome. In total, 156 individuals were included and randomized to an eight-week treatment or wait-list control...
August 2017: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/28521249/using-a-videogame-to-facilitate-nursing-and-medical-students-first-visit-to-the-operating-theatre-a-randomized-controlled-trial
#4
RANDOMIZED CONTROLLED TRIAL
Ángel Del Blanco, Javier Torrente, Baltasar Fernández-Manjón, Pedro Ruiz, Manuel Giner
BACKGROUND: First experiences in the operating theatre with real patients are always stressful and intimidating for students. We hypothesized that a game-like simulation could improve perceptions and performance of novices. METHODS: A videogame was developed, combining pictures and short videos, by which students are interactively instructed on acting at the surgical block. Moreover, the game includes detailed descriptive information. After playing, students are given feedback on their performance...
August 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28506863/the-null-test-for-peptide-identification-algorithm-in-shotgun-proteomics
#5
Shu-Rong Zhang, Yi-Chu Shan, Hao Jiang, Jian-Hui Liu, Yuan Zhou, Li-Hua Zhang, Yu-Kui Zhang
The present research proposed general evaluation strategy named Null-Test for peptide identification algorithm in Shotgun proteomics. The Null-Test method based on random matching can be utilized to check whether the algorithm has a tendency to make a mistake or has potential bugs, faultiness, errors etc., and to validate the reliability of the identification algorithm. Unfortunately, none of the five famous identification software could pass the most stringent Null-Test. PatternLab had good performance in both Null-Test and routine search by making a good control on the overfitting with sound design...
May 12, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28484867/regional-brain-volume-reduction-and-cognitive-outcomes-in-preterm-children-at-low-risk-at-9%C3%A2-years-of-age
#6
Ebru Arhan, Kıvılcım Gücüyener, Şebnem Soysal, Şafak Şalvarlı, M Ali Gürses, Ayşe Serdaroğlu, Ercan Demir, Ebru Ergenekon, Canan Türkyılmaz, Esra Önal, Esin Koç, Yıldız Atalay
OBJECTIVE: More information is needed on "low-risk" preterm infants' neurological outcome so that they can be included in follow-up programs. A prospective study was performed to examine the regional brain volume changes compared to term children and to assess the relationship between the regional brain volumes to cognitive outcome of the low-risk preterm children at 9 years of age. PATIENTS: Subjects comprised 22 preterm children who were determined to be at low risk for neurodevelopmental deficits with a gestational age between 28 and 33 weeks without a major neonatal morbidity in the neonatal period and 24 age-matched term control children term and matched for age, sex, and parental educational and occupational status...
May 8, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28477289/predictors-of-relapse-or-maintenance-of-response-in-pediatric-and-adult-patients-with-attention-deficit-hyperactivity-disorder-following-discontinuation-of-long-term-treatment-with-atomoxetine
#7
Johannes Thome, Ralf W Dittmann, Laurence L Greenhill, Sarah Lipsius, Yoko Tanaka, Chris Bushe, Rodrigo Escobar, Alexandra N Heinloth, Himanshu Upadhyaya
We identified relapse/maintenance-of-response (MOR) predictors following discontinuation of long-term atomoxetine treatment in pediatric and adult patients with attention-deficit/hyperactivity disorder (ADHD) and assessed correlations between ADHD symptoms and quality of life (QoL). Post hoc analyses of data from two randomized, double-blind, placebo-controlled, phase 3 withdrawal studies in patients with ADHD meeting predefined response criteria before randomization. Study 1: patients (N = 163; 6-15 years) received atomoxetine (1...
May 5, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/28476865/accounting-for-sampling-error-in-genetic-eigenvalues-using-random-matrix-theory
#8
Jacqueline L Sztepanacz, Mark W Blows
The distribution of genetic variance in multivariate phenotypes is characterized by the empirical spectral distribution of the eigenvalues of the genetic covariance matrix. Empirical estimates of genetic eigenvalues from random effects linear models are known to be overdispersed by sampling error, where large eigenvalues are biased upward, and small eigenvalues are biased downward. The overdispersion of the leading eigenvalues of sample covariance matrices have been demonstrated to conform to the Tracy-Widom (TW) distribution...
July 2017: Genetics
https://www.readbyqxmd.com/read/28397435/female-and-male-orbit-asymmetry-digital-analysis
#9
Tomasz Lepich, Józefa Dąbek, Małgorzata Witkowska, Edyta Jura-Szołtys, Grzegorz Bajor
BACKGROUND: Standard anthropometric methods applied to measurements of the skull differentials are laden with mistakes stemming from the way the measuring devices are built and from a lack of experience on the part of the researchers. To increase objectivity, digital imaging measurements via computer systems were introduced. OBJECTIVES: The aim of this research was to assess the asymmetry of the male and female orbit with the application of the new graphic methods: raster graphics and vector graphics...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28303702/studies-on-the-quality-nutrition-in-women-with-polycystic-ovary-syndrome-pcos
#10
Małgorzata Szczuko, Patrycja Sankowska, Marta Zapałowska-Chwyć, Paweł Wysokiński
Background: Polycystic ovary syndrome (PCOS) manifests itself with various symptoms, therefore it interests representatives of many medical specializations: general practitioners, gynecologists, endocrinologists, dermatologists, cardiologists and those who deal with metabolic disorders, such as dieticians. Objective: The aim of this study was perform the qualitative assessment of components of diets of women with PCOS as one of the major factor contributing to the disease...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28299410/the-power-law-of-movement-an-example-of-a-behavioral-illusion
#11
Richard S Marken, Dennis M Shaffer
The curved movements produced by living organisms follow a power law where the velocity of movement is a power function of the degree of curvature through which the movement is made. The exponent of the power function is close to either 1/3 or 2/3 depending on how velocity and curvature are measured. This power law is thought to reflect biological and/or kinematic constraints on how organisms produce movements. The present paper shows that the power law is actually a statistical artifact that results from mistaking a correlational for a causal relationship between variables...
March 15, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28257642/meta-evaluation-of-meta-analysis-ten-appraisal-questions-for-biologists
#12
REVIEW
Shinichi Nakagawa, Daniel W A Noble, Alistair M Senior, Malgorzata Lagisz
Meta-analysis is a statistical procedure for analyzing the combined data from different studies, and can be a major source of concise up-to-date information. The overall conclusions of a meta-analysis, however, depend heavily on the quality of the meta-analytic process, and an appropriate evaluation of the quality of meta-analysis (meta-evaluation) can be challenging. We outline ten questions biologists can ask to critically appraise a meta-analysis. These questions could also act as simple and accessible guidelines for the authors of meta-analyses...
March 3, 2017: BMC Biology
https://www.readbyqxmd.com/read/28244629/misconceptions-amongst-dental-students-how-can-they-be-identified
#13
R Grazziotin-Soares, S L Lind, D M Ardenghi, D A Curtis
AIM: To compare the frequency of misconceptions amongst dental students resulting from assessments in different subject areas using different types of multiple-choice questions (MCQs). We wanted to know whether misconceptions, or strongly held incorrect beliefs, differed by subject area or question type. METHODS: A total of 104 students completed two assessments that included 20 MCQs on endodontics and 20 MCQs on dental implants. On each examination, 10 questions were scenario-type questions requiring interpretation or analysis and 10 questions were factual-based, knowledge questions...
February 28, 2017: European Journal of Dental Education: Official Journal of the Association for Dental Education in Europe
https://www.readbyqxmd.com/read/28134586/blood-bank-specimen-mislabeling-a-college-of-american-pathologists-q-probes-study-of-41%C3%A2-333-blood-bank-specimens-in-30-institutions
#14
MULTICENTER STUDY
David A Novis, Paul F Lindholm, Glenn Ramsey, Kirsten W Alcorn, Rhona J Souers, Barbara Blond
CONTEXT: -Incorrectly labeled patient blood specimens create opportunities for laboratory testing personnel to mistake one patient's specimen for a specimen from a different patient. Transfusion of blood that is typed on specimens that are mislabeled can result in acute hemolytic transfusion reactions. OBJECTIVE: -To assess the rates of blood bank ABO typing specimens that are mislabeled and/or contain blood belonging to another patient (so-called wrong blood in tube [WBIT]), and to compare these rates with those determined in a similar study performed in 2007...
February 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28133718/bilateral-effects-of-hospital-patient-safety-procedures-on-nurses-job-satisfaction
#15
T Inoue, R Karima, K Harada
AIM: The aim of this study was to examine how hospital patient-safety procedures affect the job satisfaction of hospital nurses. Additionally, we investigated the association between perceived autonomy and hospital patient-safety procedures and job satisfaction. BACKGROUND: Recently, measures for patient safety have been recognized as an essential requirement in hospitals. Hospital patient-safety procedures may enhance the job satisfaction of nurses by improving the quality of their work...
January 30, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28120085/neuropsychological-assessment-in-the-differential-diagnosis-of-idiopathic-normal-pressure-hydrocephalus-an-important-tool-for-the-maintenance-and-restoration-of-neuronal-and-neuropsychological-functions
#16
Carmela Sindorio, Rosaria Viola Abbritti, Giovanni Raffa, Stefano M Priola, Antonino Germanò, Massimiliano Visocchi, Maria C Quattropani
Idiopathic normal pressure hydrocephalus (iNPH) is a progressive clinical syndrome that includes gait disturbances, urinary incontinence, and cognitive impairment. iNPH shows similarities to other neurodegenerative disorders, primarily Alzheimer's Disease (AD). Definition of the neuropsychological profile of iNPH and the qualitative analysis of systematic mistakes made in cognitive tests could represent a valid method for systematizing possible specific markers of iNPH dementia and differentiating it from other dementias...
2017: Acta Neurochirurgica. Supplement
https://www.readbyqxmd.com/read/28114911/the-intention-to-disclose-medical-errors-among-doctors-in-a-referral-hospital-in-north-malaysia
#17
Arvinder-Singh Hs, Abdul Rashid
BACKGROUND: In this study, medical errors are defined as unintentional patient harm caused by a doctor's mistake. This topic, due to limited research, is poorly understood in Malaysia. The objective of this study was to determine the proportion of doctors intending to disclose medical errors, and their attitudes/perception pertaining to medical errors. METHODS: This cross-sectional study was conducted at a tertiary public hospital from July- December 2015 among 276 randomly selected doctors...
January 23, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28104486/valid-statistical-approaches-for-analyzing-sholl-data-mixed-effects-versus-simple-linear-models
#18
Machelle D Wilson, Sunjay Sethi, Pamela J Lein, Kimberly P Keil
BACKGROUND: The Sholl technique is widely used to quantify dendritic morphology. Data from such studies, which typically sample multiple neurons per animal, are often analyzed using simple linear models. However, simple linear models fail to account for intra-class correlation that occurs with clustered data, which can lead to faulty inferences. NEW METHOD: Mixed effects models account for intra-class correlation that occurs with clustered data; thus, these models more accurately estimate the standard deviation of the parameter estimate, which produces more accurate p-values...
March 1, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28095192/spike-centered-jitter-can-mistake-temporal-structure
#19
Jonathan Platkiewicz, Eran Stark, Asohan Amarasingham
Jitter-type spike resampling methods are routinely applied in neurophysiology for detecting temporal structure in spike trains (point processes). Several variations have been proposed. The concern has been raised, based on numerical experiments involving Poisson spike processes, that such procedures can be conservative. We study the issue and find it can be resolved by reemphasizing the distinction between spike-centered (basic) jitter and interval jitter. Focusing on spiking processes with no temporal structure, interval jitter generates an exact hypothesis test, guaranteeing valid conclusions...
March 2017: Neural Computation
https://www.readbyqxmd.com/read/28064161/statistical-significance-versus-clinical-relevance
#20
Marieke H C van Rijn, Anneke Bech, Jean Bouyer, Jan A J G van den Brand
In March this year, the American Statistical Association (ASA) posted a statement on the correct use of P-values, in response to a growing concern that the P-value is commonly misused and misinterpreted. We aim to translate these warnings given by the ASA into a language more easily understood by clinicians and researchers without a deep background in statistics. Moreover, we intend to illustrate the limitations of P-values, even when used and interpreted correctly, and bring more attention to the clinical relevance of study findings using two recently reported studies as examples...
April 1, 2017: Nephrology, Dialysis, Transplantation
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