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MiRNA obesity

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https://www.readbyqxmd.com/read/28429344/up-regulation-of-microrna-367-promotes-liver-steatosis-through-repressing-tbl1-in-obese-mice
#1
D-D Li, Y Liu, L Xue, D-Y Su, W-Y Pang
OBJECTIVE: Increasing evidence has demonstrated that microRNAs (miRNAs) play a critical role in the progression of metabolic disorders, including obesity-induced non-alcoholic fatty liver disease (NAFLD). In the present study, the expression and function of miR-367 were investigated. MATERIALS AND METHODS: C57BL/6 male mice aged 8 weeks were fed with a normal diet (ND) or high-fat-diet (HFD). The expression levels of miR-367 were analyzed in livers from two groups of mice by quantitative real-time PCR...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28397375/elevation-of-circulating-microrna-levels-in-obese-children-compared-to-healthy-controls
#2
M D Thompson, M J Cismowski, M Serpico, A Pusateri, D R Brigstock
As childhood obesity increases, it is becoming important to understand the complications of obesity in children and develop novel biomarkers. Evidence indicates that microRNAs (miRNA) are dys-regulated in obesity and may serve as sensitive and specific circulating biomarkers. Non-alcoholic fatty liver disease (NAFLD) is a complication of obesity that ultimately requires a liver biopsy to determine disease severity. While studies have been conducted in adults, no study to date has examined circulating miRNAs in children with obesity and NAFLD...
April 10, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/28386478/changes-in-the-microrna-profile-observed-in-the-subcutaneous-adipose-tissue-of-obese-patients-after-laparoscopic-adjustable-gastric-banding
#3
Carmela Nardelli, Laura Iaffaldano, Vincenzo Pilone, Giuseppe Labruna, Maddalena Ferrigno, Nicola Carlomagno, Concetta Anna Dodaro, Pietro Forestieri, Pasqualina Buono, Francesco Salvatore, Lucia Sacchetti
Background. Laparoscopic adjustable gastric banding (LAGB) results in significant lasting weight loss and improved metabolism in obese patients. To evaluate whether epigenetic factors could concur to these benefits, we investigated the subcutaneous adipose tissue (SAT) microRNA (miRNA) profile before (T0) and three years (T1) after LAGB in three morbidly obese women. Case Reports. SAT miRNA profiling, evaluated by TaqMan Array, showed four downexpressed (miR-519d, miR-299-5p, miR-212, and miR-671-3p) and two upexpressed (miR-370 and miR-487a) miRNAs at T1 versus T0...
2017: Journal of Obesity
https://www.readbyqxmd.com/read/28381526/mirna-132-induces-hepatic-steatosis-and-hyperlipidaemia-by-synergistic-multitarget-suppression
#4
Geula Hanin, Nadav Yayon, Yonat Tzur, Rotem Haviv, Estelle R Bennett, Shiran Udi, Yoganathan R Krishnamoorthy, Eleni Kotsiliti, Rivka Zangen, Ben Efron, Joseph Tam, Orit Pappo, Eyal Shteyer, Eli Pikarsky, Mathias Heikenwalder, David S Greenberg, Hermona Soreq
OBJECTIVE: Both non-alcoholic fatty liver disease (NAFLD) and the multitarget complexity of microRNA (miR) suppression have recently raised much interest, but the in vivo impact and context-dependence of hepatic miR-target interactions are incompletely understood. Assessing the relative in vivo contributions of specific targets to miR-mediated phenotypes is pivotal for investigating metabolic processes. DESIGN: We quantified fatty liver parameters and the levels of miR-132 and its targets in novel transgenic mice overexpressing miR-132, in liver tissues from patients with NAFLD, and in diverse mouse models of hepatic steatosis...
April 5, 2017: Gut
https://www.readbyqxmd.com/read/28368446/dysregulation-of-placental-mirna-in-maternal-obesity-is-associated-with-pre-and-post-natal-growth
#5
Gemma Carreras-Badosa, Alexandra Bonmatí, Francisco-Jose Ortega, Josep-Maria Mercader, Marta Guindo-Martínez, David Torrents, Anna Prats-Puig, Jose-Maria Martinez-Calcerrada, Francis DE Zegher, Lourdes Ibáñez, Jose-Manuel Fernandez-Real, Abel Lopez-Bermejo, Judit Bassols
Context: Human placenta exhibits a specific miRNA expression pattern. Some of these miRNAs are dysregulated in pregnancy disorders like preeclampsia and intrauterine growth restriction, and are potential biomarkers for these pathologies. Objective: To study the placental miRNA profile in pregnant women with pregestational (preOB) or gestational obesity (gestOB) and explore the associations of placental miRNAs dysregulated in maternal obesity with pre- and post-natal growth...
March 20, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28344345/gastric-bypass-surgery-with-exercise-alters-plasma-micrornas-that-predict-improvements-in-cardiometabolic-risk
#6
Y O Nunez Lopez, P M Coen, B H Goodpaster, A A Seyhan
BACKGROUND/OBJECTIVES: Roux-en-Y gastric bypass (RYGB) surgery improves insulin sensitivity (SI) and β-cell function in obese non-diabetic subjects. Exercise also improves SI and may be an effective adjunct therapy to RYGB surgery. However, the mechanisms by which exercise or weight loss improve peripheral SI after RYGB surgery are unclear. We hypothesized that microRNAs (miRNAs) mediate at least some of the regulatory processes driving such mechanisms. Consequently, this work aimed at profiling plasma miRNAs in participants of the Physical Activity Following Surgery Induced Weight Loss study (clinicaltrials...
April 25, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28342299/plasma-microrna-signature-predicting-weight-gain-among-mexican-american-women
#7
Hua Zhao, Jie Shen, Carrie Daniel-MacDougall, Xifeng Wu, Wong-Ho Chow
OBJECTIVE: There is growing evidence that circulating microRNAs (miRNAs) play an important role in obesity. However, whether they can contribute to adult weight gain is still unclear. METHODS: In the training set with 40 nonsmoking, healthy women identified from the Mano-A-Mano Mexican American Cohort study, global circulating miRNA profiles in plasma samples were assessed. Cox proportional hazard regression was used to assess the effects of plasma miRNAs on significant weight gain during a 5-year follow-up...
March 25, 2017: Obesity
https://www.readbyqxmd.com/read/28333713/micrornas-and-lipid-metabolism
#8
Binod Aryal, Abhishek K Singh, Noemi Rotllan, Nathan Price, Carlos Fernández-Hernando
PURPOSE OF REVIEW: Work over the past decade has identified the important role of microRNAs (miRNAS) in regulating lipoprotein metabolism and associated disorders including metabolic syndrome, obesity, and atherosclerosis. This review summarizes the most recent findings in the field, highlighting the contribution of miRNAs in controlling LDL-cholesterol (LDL-C) and HDL-cholesterol (HDL-C) metabolism. RECENT FINDINGS: A number of miRNAs have emerged as important regulators of lipid metabolism, including miR-122 and miR-33...
March 22, 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28301325/circulating-mirnas-as-biomarkers-of-gait-speed-responses-to-aerobic-exercise-training-in-obese-older-adults
#9
Tan Zhang, Tina E Brinkley, Keqin Liu, Xin Feng, Anthony P Marsh, Stephen Kritchevsky, Xiaobo Zhou, Barbara J Nicklas
Gait speed is a useful predictor of adverse outcomes, including incident mobility disability and mortality in older adults. While aerobic exercise training (AEX) is generally an effective therapy to improve gait speed, individual responses are highly variable. Circulating microRNAs (miRNAs) may contribute to inter-individual changes in gait speed with AEX. We examined whether plasma miRNAs are associated with gait speed changes (dGaitSp) in 33 obese older adults (age: 69.3±3.6 years, BMI: 34.0±3.1 kg/m(2), 85% white, 73% women) who performed treadmill walking, 4 days/week for 5 months...
March 15, 2017: Aging
https://www.readbyqxmd.com/read/28280348/questionable-accuracy-of-home-blood-pressure-measurements-in-the-obese-population-validation-of-the-microlife-watchbp-o3-%C3%A2-and-omron-rs6-%C3%A2-devices-according-to-the-european-society-of-hypertension-international-protocol
#10
Alaa Azaki, Reem Diab, Aya Harb, Roland Asmar, Mirna N Chahine
OBJECTIVE: Two oscillometric devices, the Microlife WatchBP O3(®) and the Omron RS6(®), designed for self-blood pressure measurement were evaluated according to the European Society of Hypertension (ESH)-International Protocol (IP) Revision 2010 in the obese population. METHODS: The Microlife WatchBP O3 measures blood pressure (BP) at the brachial level and the Omron RS6 measures BP at the wrist level. The ESH-IP revision 2010 includes a total of 33 subjects. The difference between observers' and device BP values was calculated for each measure...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/28270439/comprehensive-functional-screening-of-mirnas-involved-in-fat-cell-insulin-sensitivity-among-women
#11
Ingrid Dahlman, Yasmina Belarbi, Jurga Laurencikiene, Annie M Pettersson, Peter Arner, Agné Kulyté
The key pathological link between obesity and type 2 diabetes is insulin resistance but the molecular mechanisms are not entirely identified. MicroRNAs (miRNA) are dysregulated in obesity and may contribute to insulin resistance. Our objective was to detect and functionally investigate miRNAs linked to insulin sensitivity in human subcutaneous white adipose tissue (scWAT). Subjects were selected based on the insulin-stimulated lipogenesis response of subcutaneous adipocytes. Global miRNA profiling was performed in abdominal scWAT of 18 obese insulin resistance (OIR), 21 obese insulin sensitive (OIS) and nine lean women...
March 7, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28193283/circulatory-microrna-23a-and-microrna-23b-and-polycystic-ovary-syndrome-pcos-the-effects-of-body-mass-index-and-sex-hormones-in-an-eastern-han-chinese-population
#12
Weixi Xiong, Ying Lin, Lili Xu, Amin Tamadon, Shien Zou, Fubo Tian, Ruijin Shao, Xin Li, Yi Feng
BACKGROUND: MicroRNAs (miRNAs) regulate the expression of genes involved in various cellular functions related to metabolism, inflammation, and reproduction. This study evaluated the effects of sex hormones and obesity on the expression of circulating miR-23a and miR-23b in women with polycystic ovary syndrome (PCOS) and healthy women. METHODS: Serum sex hormones concentrations and body mass index (BMI) were measured in 18 women with PCOS and in 30 healthy women from the East China area and these measurements were correlated with serum miR-23a/b levels...
February 13, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28174094/recent-advances-in-hepatocellular-carcinoma-therapy
#13
REVIEW
Rinku Dutta, Ram I Mahato
Hepatocellular carcinoma (HCC), also called malignant hepatoma, is one of the deadliest cancers due to its complexities, reoccurrence after surgical resection, metastasis and heterogeneity. Incidence and mortality of HCC are increasing in Western countries and are expected to rise as a consequence of the obesity epidemic. Multiple factors trigger the initiation and progression of HCC including chronic alcohol consumption, viral hepatitis B and C infection, metabolic disorders and age. Although Sorafenib is the only FDA approved drug for the treatment of HCC, numerous treatment modalities such as transcatheter arterial chemoembolization/transarterial chemoembolization (TACE), radiotherapy, locoregional therapy and chemotherapy have been tested in the clinics...
February 5, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28167956/micrornas-dependent-regulation-of-ppars-in-metabolic-diseases-and-cancers
#14
REVIEW
Dorothea Portius, Cyril Sobolewski, Michelangelo Foti
Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-dependent nuclear receptors, which control the transcription of genes involved in energy homeostasis and inflammation and cell proliferation/differentiation. Alterations of PPARs' expression and/or activity are commonly associated with metabolic disorders occurring with obesity, type 2 diabetes, and fatty liver disease, as well as with inflammation and cancer. Emerging evidence now indicates that microRNAs (miRNAs), a family of small noncoding RNAs, which fine-tune gene expression, play a significant role in the pathophysiological mechanisms regulating the expression and activity of PPARs...
2017: PPAR Research
https://www.readbyqxmd.com/read/28158925/mirnas-in-human-subcutaneous-adipose-tissue-effects-of-weight-loss-induced-by-hypocaloric-diet-and-exercise
#15
Malene M Kristensen, Peter K Davidsen, Andreas Vigelsø, Christina N Hansen, Lars J Jensen, Niels Jessen, Jens M Bruun, Flemming Dela, Jørn W Helge
OBJECTIVE: Obesity is central in the development of insulin resistance. However, the underlying mechanisms still need elucidation. Dysregulated microRNAs (miRNAs; post-transcriptional regulators) in adipose tissue may present an important link. METHODS: The miRNA expression in subcutaneous adipose tissue from 19 individuals with severe obesity (10 women and 9 men) before and after a 15-week weight loss intervention was studied using genome-wide microarray analysis...
February 3, 2017: Obesity
https://www.readbyqxmd.com/read/28122254/an-alpha-beta-of-pancreatic-islet-microribonucleotides
#16
REVIEW
Louise Torp Dalgaard, Lena Eliasson
MicroRNAs (miRNAs) are cellular, short, non-coding ribonucleotides acting as endogenous posttranscriptional repressors following incorporation in the RNA-induced silencing complex. Despite being chemically and mechanistically very similar, miRNAs exert a multitude of different cellular effects by acting on mRNA species, whose gene-products partake in a wide array of processes. Here, the aim was to review the knowledge of miRNA expression and action in the islet of Langerhans. We have focused on: 1) physiological consequences of islet or beta cell specific inhibition of miRNA processing, 2) mechanisms regulating processing of miRNAs in islet cells, 3) presence and function of miRNAs in alpha versus beta cells - the two main cell types of islets, and 4) miRNA mediators of beta cell decompensation...
January 22, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28119530/decreased-lipid-metabolism-but-increased-fa-biosynthesis-are-coupled-with-changes-in-liver-micrornas-in-obese-subjects-with-nafld
#17
J Latorre, J M Moreno-Navarrete, J M Mercader, M Sabater, Ò Rovira, J Gironès, W Ricart, J M Fernández-Real, F J Ortega
BACKGROUND/OBJECTIVE: Many controversies regarding the association of liver miRNAs with obesity and nonalcoholic fatty liver diseases (NAFLD) call for additional validations. This study sought to investigate variations in genes and hepatic miRNAs in a sample of obese patients with or without NAFLD and human hepatocytes (HH). SUBJECTS/METHODS: A total of 60 non-consecutive obese women following bariatric surgery were recruited. Subjects were classified as NAFLD (n=17), borderline (n=24) and controls (n=19) with normal enzymatic profile, liver histology and ultrasound assessments...
April 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28095800/diet-gonadal-sex-and-sex-chromosome-complement-influence-white-adipose-tissue-mirna-expression
#18
Jenny C Link, Yehudit Hasin-Brumshtein, Rita M Cantor, Xuqi Chen, Arthur P Arnold, Aldons J Lusis, Karen Reue
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression by targeting specific mRNA species for degradation or interfering with translation. Specific miRNAs are key regulators of adipogenesis, and are expressed at different levels in adipose tissue from lean and obese mice. The degree of lipid accumulation and distribution of white adipose tissue differs between males and females, and it is unknown whether sex differences in adipose tissue-specific miRNA expression may contribute to this dimorphism...
January 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28071834/molecular-profiling-of-human-induced-pluripotent-stem-cell-derived-hypothalamic-neurones-provides-developmental-insights-into-genetic-loci-for-body-weight-regulation
#19
L Yao, Y Liu, Z Qiu, S Kumar, J E Curran, J Blangero, Y Chen, D M Lehman
Recent data suggest that common genetic risks for metabolic disorders such as obesity may be human-specific and exert effects via the central nervous system. To overcome the limitation of human tissue access for study, we have generated induced human pluripotent stem cell (hiPSC)-derived neuronal cultures that recapture many features of hypothalamic neurones within the arcuate nucleus. In the present study, we have comprehensively characterised this model across development, benchmarked these neurones to in vivo events, and demonstrate a link between obesity risk variants and hypothalamic development...
February 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28068868/mir-26a-mediates-adipogenesis-of-amniotic-fluid-mesenchymal-stem-stromal-cells-via-pten-cyclin-e1-and-cdk6
#20
Ourania Trohatou, Dimitra Zagoura, Nikos K Orfanos, Kalliopi I Pappa, Evangelos Marinos, Nicholas P Anagnou, Maria G Roubelakis
Recent findings indicate that microRNAs (miRNAs) are critical for the regulatory network of adipogenesis in human mesenchymal stem/stromal cells (MSCs). Fetal MSCs derived from amniotic fluid (AF-MSCs) represent a population of multipotent stem cells characterized by a wide range of differentiation properties that can be applied in cell-based therapies. In this study, miRNA microarray analysis was performed to assess miRNA expression in terminal differentiated AF-MSCs into adipocyte-like cells (AL cells). MiR-26a was identified in high expression levels in AL cells indicating a critical role in the process of adipogenesis...
April 1, 2017: Stem Cells and Development
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