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MiRNA obesity

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https://www.readbyqxmd.com/read/29899524/microrna-30-modulates-metabolic-inflammation-by-regulating-notch-signaling-in-adipose-tissue-macrophages
#1
Kathryn Miranda, Xiaoming Yang, Marpe Bam, E Angela Murphy, Prakash S Nagarkatti, Mitzi Nagarkatti
BACKGROUND/OBJECTIVES: Obesity is a pandemic disorder that is characterized by accumulation of adipose tissue and chronic low-grade inflammation that is driven primarily by adipose tissue macrophages (ATMs). While ATM polarization from pro-(M1) to anti-(M2) inflammatory phenotype influences insulin sensitivity and energy expenditure, the mechanisms of such a switch are unclear. In the current study, we identified epigenetic pathways including microRNAs (miR) in ATMs that regulate obesity-induced inflammation...
June 13, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29892042/sleep-disordered-breathing-circulating-exosomes-and-insulin-sensitivity-in-adipocytes
#2
Abdelnaby Khalyfa, David Gozal, Juan F Masa, José Maria Marin, Zhuanghong Qiao, Jaime Corral, Mónica González, Sergi Marti, Leila Kheirandish-Gozal, Carlos Egea, M-Ángeles Sánchez-Quiroga, Francisco J Gómez de Terreros, F Javier Barca
BACKGROUND: Sleep-disordered-breathing (SDB), which is characterized by chronic intermittent hypoxia (IH) and sleep fragmentation (SF), is a prevalent condition that promotes metabolic dysfunction, particularly among patients suffering from obstructive hypoventilation syndrome (OHS). Exosomes are generated ubiquitously, are readily present in the circulation, and their cargo may exert substantial functional cellular alterations in both physiological and pathological conditions. However, the effects of plasma exosomes on adipocyte metabolism in patients with OHS or in mice subjected to IH or SF mimicking SDB are unclear...
June 11, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29884823/microrna-410-5p-exacerbates-high-fat-diet-induced-cardiac-remodeling-in-mice-in-an-endocrine-fashion
#3
Tong Zou, Mei Zhu, Yi-Cheng Ma, Fei Xiao, Xue Yu, Li Xu, Lan-Qing Ma, Jiefu Yang, Jian-Zeng Dong
Metabolic disorders, such as obesity and type 2 diabetes, are associated with an increased risk of cardiomyopathy. To date, microRNA (miRNAs) functions in cardiac remodeling induced by obesity remain to be elucidated. We found that rats fed a high fat diet (HFD) manifested cardiac fibrosis and LV dysfunction. In the heart of rats fed HFD, the phosphorylation levels of Smad 2 and the expression of fibrotic genes, such as connective tissue growth factor, collagen-1α1 (Col1α1), Col3α1, and Col4α1, were up-regulated, which accompanied by an increase in Smad 7 protein levels, but not its mRNA levels...
June 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29881628/improved-physiology-and-metabolic-flux-after-roux-en-y-gastric-bypass-is-associated-with-temporal-changes-in-the-circulating-micrornaome-a-longitudinal-study-in-humans
#4
Abdullah Alkandari, Hutan Ashrafian, Thozhukat Sathyapalan, Peter Sedman, Ara Darzi, Elaine Holmes, Thanos Athanasiou, Stephen L Atkin, Nigel J Gooderham
Background: The global pandemic of obesity and the metabolic syndrome are leading causes of mortality and morbidity. Bariatric surgery leads to sustained weight loss and improves obesity-associated morbidity including remission of type 2 diabetes. MicroRNAs are small, endogenous RNAs that regulate gene expression post-transcriptionally, controlling most of the human transcriptome and contributing to the regulation of systemic metabolism. This preliminary, longitudinal, repeat sampling study, in which subjects acted as their own control, aimed to assess the temporal effect of bariatric surgery on circulating microRNA expression profiles...
2018: BMC Obesity
https://www.readbyqxmd.com/read/29864940/microrna-200b-regulates-preadipocyte-proliferation-and-differentiation-by-targeting-klf4
#5
Linyuan Shen, Mailin Gan, Qiang Li, Jinyong Wang, Xuewei Li, Shunhua Zhang, Li Zhu
MicroRNAs (miRNAs) are small, non-coding RNAs that affect the post-transcriptional regulation of a variety of biological pathways. A previous study found out that miR-200b was important in the metabolism of obesity, but the mechanism of miR-200b regulateing adipogenesis is not fully understood.. In the present study, we observed that miR200b expression decreased both in obese mice and during the process of 3T3-L1 adipogenic differentiation. Overexpression of miR-200b promoted adipocyte proliferation by regulating the expression of cell cycle-regulated factors...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29852165/t2dm-inhibition-of-endothelial-mir-342-3p-facilitates-angiogenic-dysfunction-via-repression-of-fgf11-signaling
#6
Shaoyun Cheng, Yanxiang Cui, Lin Fan, Xiaofeng Mu, Yuzhong Hua
Understanding the function and molecular relevance of distinct miRNAs in endothelial cells (ECs) paves avenues for possible therapeutic intervention by targeting epigenetic mechanisms in vascular endothelial dysfunction, one of the major complications of type 2 diabetes mellitus (T2DM). MiR-342-3p, an obesity-associated miRNA, has recently been shown to be significantly upregulated in human angiosarcoma compared to benign hemangioma, indicating its potential involvement as a proangiogenic factor. Herein, we show that endothelial miR-342-3p expression was significantly compromised in T2DM organisms and this inhibition powerfully blocked vasculogenesis in vivo by repressing endothelial proliferation and migration...
May 28, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29844486/children-s-screen-time-alters-the-expression-of-saliva-extracellular-mir-222-and-mir-146a
#7
Annette Vriens, Eline B Provost, Nelly D Saenen, Patrick De Boever, Karen Vrijens, Oliver De Wever, Michelle Plusquin, Tim S Nawrot
An imbalance between energy uptake and energy expenditure is the most important reason for increasing trends in obesity starting from early in life. Extracellular miRNAs are expressed in all bodily fluids and their expression is influenced by a broad range of stimuli. We examined whether screen time, physical activity and BMI are associated with children's salivary extracellular miR-222 and miR-146a expression. In 80 children the extracellular fraction of saliva was obtained by means of differential centrifugation and ultracentrifugation...
May 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29797695/theobromine-does-not-affect-fasting-and-postprandial-hdl-cholesterol-efflux-capacity-while-it-decreases-fasting-mir-92a-levels-in-humans
#8
Charlotte P J Talbot, Ronald P Mensink, Lotte Smolders, Virginie Bakeroot, Jogchum Plat
SCOPE: Chocolate consumption lowers cardiovascular disease risk, which might be attributed to the methylxanthine theobromine. These effects may be mediated through effects on HDL-mediated cholesterol efflux, which on its turn may be affected by microRNAs (miRNAs) levels in the HDL particles. Therefore, the aim of this study was to investigate effects of theobromine consumption on fasting and postprandial cholesterol efflux and miRNAs levels. METHODS AND RESULTS: Thirty overweight and 14 obese healthy men and women participated in this randomized, double-blind crossover study...
May 24, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29787826/obesity-induced-overexpression-of-mirna-24-regulates-cholesterol-uptake-and-lipid-metabolism-by-targeting-sr-b1
#9
Meina Wang, Lulu Li, Rui Liu, Yuwei Song, Xinxin Zhang, Weijing Niu, Alagamuthu Karthick Kumar, Zhigang Guo, Zhigang Hu
Scavenger Receptor B1 (SR-B1) is an 82 kDa integral membrane glycoprotein that mediates selective uptake of high-density lipoprotein cholesteryl ester (CE) in vitro and in vivo. Previously, we defined several kinds of regulatory mechanisms of SR-B1 expression and function. Here, we have dissected the function of a novel miR-24 on SR-B1 expression, HDL uptake and lipid metabolism. We showed that miR-24 was upregulated in HepG2 cells cultured in the mimicked hyperlipidemic condition and in the livers of dietary induced and genetic obesity mice...
May 19, 2018: Gene
https://www.readbyqxmd.com/read/29782494/ubiquitin-dependent-proteolysis-of-cxcl7-leads-to-posterior-longitudinal-ligament-ossification
#10
Michiyo Tsuru, Atsushi Ono, Hideaki Umeyama, Masahiro Takeuchi, Kensei Nagata
Ossification of the posterior longitudinal ligament (OPLL), a spinal ligament, reduces the range of motion in limbs. No treatment is currently available for OPLL, which is why therapies are urgently needed. OPLL occurs in obesity, is more common in men, and has an onset after 40 years of age. The mechanisms underlying OPLL remain unclear. In this study, we performed a serum proteomic analysis in both OPLL patients and healthy subjects to identify factors potentially involved in the development of OPLL, and found reduced levels of a protein that might underlie the pathology of OPLL...
2018: PloS One
https://www.readbyqxmd.com/read/29769661/circulating-mir-374a-5p-is-a-potential-modulator-of-the-inflammatory-process-in-obesity
#11
Ayo P Doumatey, William J He, Amadou Gaye, Lin Lei, Jie Zhou, Gary H Gibbons, Adebowale Adeyemo, Charles N Rotimi
Obese individuals without expected metabolic co-morbidities are referred to as metabolically healthy obese (MHO). The molecular mechanisms underlying this phenotype remain elusive. MicroRNAs may be involved in the MHO phenotype. To test this hypothesis, we screened 179 serum miRNAs in 20 African-American women (10 MHOs and 10 metabolically abnormal obese individuals -MAO). We identified 8 differentially expressed miRNAs (DEMs) with validation in an independent sample of 64 MHO and 34 MAO. Of the eight DEMs in the screening phase (p ≤ 0...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29764990/ire1%C3%AE-prevents-hepatic-steatosis-by-processing-and-promoting-the-degradation-of-select-micrornas
#12
Jie-Mei Wang, Yining Qiu, Zhao Yang, Hyunbae Kim, Qingwen Qian, Qinghua Sun, Chunbin Zhang, Lei Yin, Deyu Fang, Sung Hong Back, Randal J Kaufman, Ling Yang, Kezhong Zhang
Obesity or a high-fat diet represses the endoribonuclease activity of inositol-requiring enzyme 1α (IRE1α), a transducer of the unfolded protein response (UPR) in cells under endoplasmic reticulum (ER) stress. An impaired UPR is associated with hepatic steatosis and nonalcoholic fatty liver disease (NAFLD), which is caused by lipid accumulation in the liver. We found that IRE1α was critical to maintaining lipid homeostasis in the liver by repressing the biogenesis of microRNAs (miRNAs) that regulate lipid mobilization...
May 15, 2018: Science Signaling
https://www.readbyqxmd.com/read/29758288/micrornas-in-brown-and-beige-fat
#13
REVIEW
Deborah Goody, Alexander Pfeifer
Brown adipose tissue (BAT) dissipates energy as heat and its activity correlates with leanness in human adults. Understanding the mechanisms behind the activation of BAT and the process of "browning", i.e. the appearance of inducible brown adipocytes called beige or brite (brown-in-white) cells in white adipose tissue (WAT), is of great interest for developing novel therapies to combat obesity. MicroRNAs (miRNAs) are small transcriptional regulators that control gene expression in a variety of tissues, including WAT and BAT...
May 11, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29753771/mir-199a-3p-regulates-brown-adipocyte-differentiation-through-mtor-signaling-pathway
#14
Yao Gao, Yan Cao, Xianwei Cui, Xingyun Wang, Yahui Zhou, Fangyan Huang, Xing Wang, Juan Wen, Kaipeng Xie, Pengfei Xu, Xirong Guo, Lianghui You, Chenbo Ji
Recent discoveries of functional brown adipocytes in mammals illuminates their therapeutic potential for combating obesity and its associated diseases. However, on account of the limited amount and activity in adult humans of brown adipocyte depots, identification of miRNAs and characterization their regulatory roles in human brown adipogenesis are urgently needed. This study focused on the role of microRNA (miR)-199a-3p in human brown adipocyte differentiation and thermogenic capacity. A decreased expression pattern of miR-199a-3p was consistently observed during the differentiation course of brown adipocytes in mice and humans...
May 10, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29751019/nighttime-light-exposure-enhances-rev-erb%C3%AE-targeting-micrornas-and-contributes-to-hepatic-steatosis
#15
Patricia C Borck, Thiago M Batista, Jean F Vettorazzi, Gabriela M Soares, Camila Lubaczeuski, Dongyin Guan, Antonio C Boschero, Elaine Vieira, Mitchell A Lazar, Everardo M Carneiro
OBJECTIVE: The exposure to artificial light at night (ALAN) disrupts the biological rhythms and has been associated with the development of metabolic syndrome. MicroRNAs (miRNAs) display a critical role in fine-tuning the circadian system and energy metabolism. In this study, we aimed to assess whether altered miRNAs expression in the liver underlies metabolic disorders caused by disrupted biological rhythms. RESULTS: We found that C3H/HePas mice exposed to ALAN developed obesity, and hepatic steatosis, which was paralleled by decreased expression of Rev-erbα and up-regulation of its lipogenic targets ACL and FAS in liver...
May 8, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29746886/exercise-training-prevents-obesity-associated-disorders-role-of-mirna-208a-and-med13
#16
Tiago Fernandes, Diego Lopes Barretti, M Ian Phillips, Edilamar Menezes de Oliveira
Exercise training (ET) has been established as an important treatment for obesity, since it counteracts aberrant cardiac metabolism and weight gain; however, underlying mechanisms remain to be further determined. MicroRNAs (miRNAs) inhibit protein expression by base-pairing with the 3' UTRs of mRNA targets. MiRNA-208a is a cardiac-specific miRNA that regulates β-MHC content and systemic energy homeostasis via MED13. We investigated whether ET regulates the cardiac miRNA-208a and its target MED13, reducing the weight gain and β-MHC expression in obese Zucker rats (OZR)...
May 7, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29734990/exosomal-cargo-properties-endothelial-function-and-treatment-of-obesity-hypoventilation-syndrome-a-proof-of-concept-study
#17
Rakesh Bhattacharjee, Abdelnaby Khalyfa, Ahamed A Khalyfa, Babak Mokhlesi, Leila Kheirandish-Gozal, Isaac Almendros, Eduard Peris, Atul Malhotra, David Gozal
STUDY OBJECTIVES: Longitudinal studies support the usage of positive airway pressure (PAP) therapy in treating obstructive sleep apnea (OSA) to improve cardiovascular disease. However, the anticipated benefit is not ubiquitous. In this study, we elucidate whether PAP therapy leads to immediate improvements on endothelial function, a subclinical marker of cardiovascular status, by examining the effect of circulating exosomes, isolated from patients before and after PAP therapy, on naive endothelial cells...
April 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29734116/polyphenol-rich-green-tea-extract-improves-adipose-tissue-metabolism-by-down-regulating-mir-335-expression-and-mitigating-insulin-resistance-and-inflammation
#18
Rosemari Otton, Anaysa Paola Bolin, Leticia Torres Ferreira, Marcelo Paradiso Marinovic, Andrea Livia Silva Rocha, Marcelo Alves Mori
Obesity leads to changes in miRNA expression in adipose tissue, and this modulation is linked to the pathophysiology of the disease. Green tea (GT) is a natural source of polyphenols that have been shown to confer health benefits, particularly preventing metabolic diseases. Here, we investigated if the beneficial effects of GT in obesity results from changes in the miRNA profile in white adipose tissue. GT treatment [500 mg/body weight (BW)/12 weeks] increased energy expenditure of high-fat diet-fed mice (16 weeks), leading to reduced weight gain, decreased adiposity, reduced inflammation and improved insulin sensitivity...
April 7, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29729889/the-inflammatory-state-of-adipose-tissue-is-not-affected-by-the-anti-inflammatory-response-of-the-a2a-adenosine-system-and-mir-221-pten
#19
J D Cortés-Garcia, M Briones-Espinoza, M Vega-Cárdenas, V M Ruíz-Rodríguez, A Mendez-Mancilla, Arturo E Gómez-Otero, J M Vargas Morales, M H García-Hernández, D P Portales-Pérez
Obesity is a chronic inflammatory state with cytokines, adipokines, and miRNAs. The A2a-adenosine system decreases activation and cytokine release in immune cells. MiR-221 is upregulated in carcinogenesis and inflammatory processes, where its targets PTEN and ETS-1, negatively regulates the Akt pathway and induces the release of pro-inflammatory cytokines, respectively. However, the roles of the A2a-adenosine system and miR-221 in adipose tissue are unknown. The aim of this work was to evaluate the A2a-adenosine and miRNA pathways as immune modulators in adipose tissue...
May 3, 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29721017/elevated-and-correlated-expressions-of-mir-24-mir-30d-mir-146a-and-sfrp-4-in-human-abdominal-adipose-tissue-play-a-role-in-adiposity-and-insulin-resistance
#20
Yury O Nunez Lopez, Gabriella Garufi, Magdalena Pasarica, Attila A Seyhan
Objective: We explored the relationships among microRNAs (miRNAs) and SFRP4, as they relate to adipose tissue functions including lipolysis, glucose and glycerol turnover, and insulin sensitivity. Methods: Abdominal adipose tissue (AbdAT) levels of thirteen microRNAs (miRNAs), SFRP4, and VEGF in lean nondiabetic subjects ( n = 7), subjects with obesity ( n = 5), and subjects with obesity and type 2 diabetes (T2DM) ( n = 5) were measured by qPCR. Insulin sensitivity was measured by the euglycemic-hyperinsulinemic clamp...
2018: International Journal of Endocrinology
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