keyword
MENU ▼
Read by QxMD icon Read
search

MiRNA obesity

keyword
https://www.readbyqxmd.com/read/29410349/non-targeted-profiling-of-circulating-micrornas-in-women-with-polycystic-ovary-syndrome-pcos-effects-of-obesity-and-sex-hormones
#1
Mora Murri, María Insenser, Elena Fernández-Durán, José L San-Millán, Manuel Luque-Ramírez, Héctor F Escobar-Morreale
PURPOSE: Circulating micro-ribonucleic acids (miRNAs) are small noncoding RNA molecules that influence gene transcription. We conducted the present profiling study to characterize the expression of circulating miRNAs in lean and obese patients with polycystic ovary syndrome (PCOS), the most common endocrine and metabolic disorder in premenopausal women. BASIC PROCEDURES: We selected 11 control women, 12 patients with PCOS and 12 men so that they were similar in terms of body mass index...
February 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29409019/altered-expression-of-mir-181a-5p-and-mir-23a-3p-is-associated-with-obesity-and-tnf%C3%AE-induced-insulin-resistance
#2
Javier Lozano-Bartolomé, Gemma Llauradó, Manel Portero Otin, Antonio Altuna-Coy, Gemma Rojo-Martínez, Joan Vendrell, Rosa Jorba, Esther Rodríguez-Gallego, Matilde R Chacón
Context: The proinflammatory cytokine TNFα is a key player in insulin resistance (IR). While several miRNAs are believed to be involved in the development of adipose tissue (AT) IR, the role of miRNAs in the association between inflammation and IR is poorly understood. Objective: To investigate the expression profile of miR-181a-5p and miR-23a-3p in obesity and to study their role in TNFα-induced IR in adipocytes. Design: Two separate cohorts were employed...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29402872/exercise-training-restores-the-cardiac-microrna-16-levels-preventing-microvascular-rarefaction-in-obese-zucker-rats
#3
Tiago Fernandes, Lilian Casaes, Úrsula Soci, Andre Silveira, João Gomes, Diego Barretti, Fernanda Roque, Edilamar Oliveira
OBJECTIVE: To evaluate the effects of aerobic exercise training (AET) on cardiac miRNA-16 levels and its target gene VEGF related to microvascular rarefaction in obese Zucker rats (OZR). METHODS: OZR (n = 11) and lean (L; n = 10) male rats were assigned into 4 groups: OZR, trained OZR (OZRT), L and trained L (LT). Swimming exercise training lasted 60 min, 1×/day/10 weeks, with 4% body weight workload. Cardiac angiogenesis was assessed by histological analysis (periodic acid-Schiff) by calculating the capillary/fiber ratio...
February 7, 2018: Obesity Facts
https://www.readbyqxmd.com/read/29393878/microrna-125a-5p-mediates-3t3-l1-preadipocyte-proliferation-and-differentiation
#4
Yan Xu, Jingjing Du, Peiwen Zhang, Xue Zhao, Qiang Li, Anan Jiang, Dongmei Jiang, Guoqing Tang, Yanzhi Jiang, Jinyong Wang, Xuewei Li, Shunhua Zhang, Li Zhu
Excessive accumulation of adipose tissue is a main cause of obesity or overweight, which is significantly involved in increasing the risk of diseases. Recently, numerous studies have proved that microRNAs (miRNAs) play important roles in adipogenesis by negatively regulating gene expression at posttranscriptional levels. In this study, we showed that miR-125a-5p was expressed at lower levels in the adipose tissues of high-fat diet (HFD)-fed mice than the normal chow (NCW)-fed mice. MiR-125a-5p expression were strongly up-regulated by nearly five-fold, when 3T3-L1 preadipocyte were induced and differentiated into mature adipocytes...
February 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29391168/mapping-diet-induced-alternative-polyadenylation-of-hypothalamic-transcripts-in-the-obese-rat
#5
Julianna N Brutman, Xiang Zhou, Yangzi Zhang, Jennifer Michal, Bastian Stark, Zhihua Jiang, Jon F Davis
RNA biogenesis has emerged as a powerful biological event that regulates energy homeostasis. In this context insertion of alternative polyadenylation sites (APSs) dictate the fate of newly synthesized RNA molecules and direct alternative splicing of nascent transcripts. Thus APSs serve a mechanistic function by regulating transcriptome expression and function. In this study we employed a novel RNA-Seq Next Generation Sequencing (NGS) approach that utilized the power of Whole Transcriptome Termini Site Sequencing (WTTS-Seq) to simultaneously measure APS events on multiple RNA biotypes...
January 29, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29383120/integrated-analysis-of-mrna-and-mirna-expression-profiles-in-livers-of-yimeng-black-pigs-with-extreme-phenotypes-for-backfat-thickness
#6
Wentong Li, Yalan Yang, Ying Liu, Shuai Liu, Xiuxiu Li, Yingping Wang, Yanmin Zhang, Hui Tang, Rong Zhou, Kui Li
Fat deposition is an important economic trait in farm animals as well as obesity related diseases in humans, and the liver is a central organ involved in regulating lipid synthesis and metabolism in mammals. In this study, the pig liver transcriptome of two groups (H and L) showing differences in backfat thickness were profiled using RNA-Seq and miRNA-Seq to further explore the molecular mechanism of fat deposition. A total of 238 differentially expressed genes (DEGs) and 58 differentially expressed miRNAs were identified between the H and L group...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29374557/molecular-paths-linking-metabolic-diseases-gut-microbiota-dysbiosis-and-enterobacteria-infections
#7
REVIEW
Matteo Serino
Alterations of both ecology and functions of gut microbiota are conspicuous traits of several inflammatory pathologies, notably metabolic diseases such as obesity and type 2 diabetes. Moreover, the proliferation of enterobacteria, subdominant members of the intestinal microbial ecosystem, has been shown to be favoured by western diet, the strongest inducer of both metabolic diseases and gut microbiota dysbiosis. The inner interdependence between the host and the gut microbiota is based on a plethora of molecular mechanisms by which host and intestinal microbes modify each other...
January 25, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29364977/identification-of-microrna-that-represses-irs-1-expression-in-liver
#8
Kaoru Ono, Motoyuki Igata, Tatsuya Kondo, Sayaka Kitano, Yuki Takaki, Satoko Hanatani, Masaji Sakaguchi, Rieko Goto, Takafumi Senokuchi, Junji Kawashima, Noboru Furukawa, Hiroyuki Motoshima, Eiichi Araki
MicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally regulate gene expression and have been shown to participate in almost every cellular process. Several miRNAs have recently been implicated in glucose metabolism, but the roles of miRNAs in insulin-resistant conditions, such as obesity or type 2 diabetes, are largely unknown. Herein, we focused on miR-222, the expression of which was increased in the livers of high fat/high sucrose diet-fed mice injected with gold thioglucose (G+HFHSD)...
2018: PloS One
https://www.readbyqxmd.com/read/29352962/improved-systemic-metabolism-and-adipocyte-biology-in-mir-150-knockout-mice
#9
Minsung Kang, Xiaobing Liu, Yuchang Fu, W Timothy Garvey
INTRODUCTION: Short non-coding micro-RNAs (miRNAs) are post-transcriptional factors that directly regulate protein expression by degrading or inhibiting target mRNAs; however, the role of miRNAs in obesity and cardiometabolic disease remains unclarified. Based on our earlier study demonstrating that miR-150 influences lipid metabolism, we have studied effects of miR-150 on systemic metabolism and adipocyte biology. MATERIALS AND METHODS: Metabolic phenotypes including body weight, food intake, body composition, glucose tolerance and insulin sensitivity were assessed in WT and global miR-150 KO male mice fed a high-fat diet...
January 15, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29280944/ngs-reveals-molecular-pathways-affected-by-obesity-and-weight-loss-related-changes-in-mirna-levels-in-adipose-tissue
#10
Alina Kuryłowicz, Zofia Wicik, Magdalena Owczarz, Marta Izabela Jonas, Marta Kotlarek, Michał Świerniak, Wojciech Lisik, Maurycy Jonas, Bartłomiej Noszczyk, Monika Puzianowska-Kuźnicka
Both obesity and weight loss may cause molecular changes in adipose tissue. This study aimed to characterize changes in adipose tissue miRNome in order to identify molecular pathways affected by obesity and weight changes. Next generation sequencing (NGS) was applied to identify microRNAs (miRNAs) differentially expressed in 47 samples of visceral (VAT) and subcutaneous (SAT) adipose tissues from normal-weight (N), obese (O) and obese after surgery-induced weight loss (PO) individuals. Subsequently miRNA expression was validated by real-time PCR in 197 adipose tissues and bioinformatics analysis performed to identify molecular pathways affected by obesity-related changes in miRNA expression...
December 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29280351/mir-27b-3p-regulation-in-browning-of-human-visceral-adipose-related-to-central-obesity
#11
Jing Yu, Yifan Lv, Wenjuan Di, Juan Liu, Xiaocen Kong, Yunlu Sheng, Min Huang, Shan Lv, Hanmei Qi, Mei Gao, Hui Liang, Sarah Kim, Zan Fu, Hong Zhou, Guoxian Ding
OBJECTIVE: Given the rising prevalence of central obesity and the discovery that beige cells appear within white adipose tissue, strategies to enhance these energy-expending adipocytes or "browning" within white adipose depots have become of therapeutic interest to combat obesity and its associated disorders. This study focused on, the role of microRNA (miRNA)-27b-3p in human visceral adipose tissue (VAT) browning. METHODS: Expression of miR-27b-3p and UCP1 in VAT and serum of humans was measured...
February 2018: Obesity
https://www.readbyqxmd.com/read/29248466/leptin-suppresses-microrna-122-promoter-activity-by-phosphorylation-of-foxo1-in-hepatic-stellate-cell-contributing-to-leptin-promotion-of-mouse-liver-fibrosis
#12
Qing Cao, Xiaofei Zhu, Xuguang Zhai, Li Ji, Fangyun Cheng, Yiqi Zhu, Pengfei Yu, Yajun Zhou
Adipocytokine leptin promotes hepatic stellate cell (HSC) activation (a key step in liver fibrogenesis) and liver fibrosis. microRNA-122 (miR-122) is the most abundant liver-specific miRNA and was demonstrated to inhibit liver fibrosis and reduced HSC proliferation. Our previous study revealed that leptin reduced miR-122 level in HSCs. This study was aimed to investigate whether leptin affected miR-122 promoter and the underlying mechanisms in HSCs. Results showed that leptin inhibited miR-122 promoter activity...
December 14, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29243809/obesity-induced-mitochondrial-dysfunction-in-porcine-adipose-tissue-derived-mesenchymal-stem-cells
#13
Yu Meng, Alfonso Eirin, Xiang-Yang Zhu, Hui Tang, Pritha Chanana, Amir Lerman, Andre J van Wijnen, Lilach O Lerman
BACKGROUND: Transplantation of autologous mesenchymal stem cells (MSCs) may be a viable option for treatment of several diseases. MSCs efficacy depends on adequate function of their mitochondria, which might be impaired in a noxious milieu. OBJECTIVES: We hypothesized that obesity compromises MSCs mitochondrial structure and function, possibly via micro-RNA (miRNA)-based mechanisms. METHODS: MSCs were collected from swine abdominal adipose tissue after 16 weeks of Lean or Obese diet (n = 7 each)...
December 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29233981/a-mir-327-fgf10-fgfr2-mediated-autocrine-signaling-mechanism-controls-white-fat-browning
#14
Carina Fischer, Takahiro Seki, Sharon Lim, Masaki Nakamura, Patrik Andersson, Yunlong Yang, Jennifer Honek, Yangang Wang, Yanyan Gao, Fang Chen, Nilesh J Samani, Jun Zhang, Masato Miyake, Seiichi Oyadomari, Akihiro Yasue, Xuri Li, Yun Zhang, Yizhi Liu, Yihai Cao
Understanding the molecular mechanisms regulating beige adipocyte formation may lead to the development of new therapies to combat obesity. Here, we report a miRNA-based autocrine regulatory pathway that controls differentiation of preadipocytes into beige adipocytes. We identify miR-327 as one of the most downregulated miRNAs targeting growth factors in the stromal-vascular fraction (SVF) under conditions that promote white adipose tissue (WAT) browning in mice. Gain- and loss-of-function experiments reveal that miR-327 targets FGF10 to prevent beige adipocyte differentiation...
December 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29233588/changes-in-circulating-mirnas-in-healthy-overweight-and-obese-subjects-effect-of-diet-composition-and-weight-loss
#15
S Giardina, P Hernández-Alonso, A Díaz-López, A Salas-Huetos, J Salas-Salvadó, M Bulló
BACKGROUND: MicroRNAs (miRNAs) are small non-coding RNA molecules that can play an important role in several chronic metabolic conditions, including obesity. However, to date little is known about how they are regulated. Weight loss induced by surgical procedures has been effective at modulating specific circulating miRNAs, but the effect of energy-restricted diets with different macronutrient compositions on circulating miRNAs is not well understood. The objective of the present analysis was to explore the effect of three energy-restricted diets of different macronutrient composition and carbohydrate quality on plasma miRNA levels...
December 1, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29210999/adverse-intrauterine-environment-and-cardiac-mirna-expression
#16
REVIEW
Mitchell C Lock, Kimberley J Botting, Ross L Tellam, Doug Brooks, Janna L Morrison
Placental insufficiency, high altitude pregnancies, maternal obesity/diabetes, maternal undernutrition and stress can result in a poor setting for growth of the developing fetus. These adverse intrauterine environments result in physiological changes to the developing heart that impact how the heart will function in postnatal life. The intrauterine environment plays a key role in the complex interplay between genes and the epigenetic mechanisms that regulate their expression. In this review we describe how an adverse intrauterine environment can influence the expression of miRNAs (a sub-set of non-coding RNAs) and how these changes may impact heart development...
December 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29210640/fine-tuning-of-micrornas-in-type-2-diabetes-mellitus
#17
Juan A Rosado, Raquel Diez-Bello, Gines Maria Salido, I Jardin
Type 2 diabetes mellitus is a metabolic disease widely spread across industrialized countries. Sedentary lifestyle and unhealthy alimentary habits lead to obesity, boosting both glucose and fatty acid in the bloodstream and eventually, insulin resistance, pancreas inflammation and faulty insulin production or secretion, all of them very well-defined hallmarks of type 2 diabetes mellitus. miRNAs, are small sequences of non-coding RNA that may regulate several processes within the cells, fine-tuning protein expression, with an unexpected and subtle precision and in time-frames ranging from minutes to days...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29193229/identification-of-micrornas-and-genes-associated-with-hyperandrogenism-in-the-follicular-fluid-of-women-with-polycystic-ovary-syndrome
#18
Yunping Xue, Juan Lv, Pengfei Xu, Lin Gu, Jian Cao, Lingling Xu, Kai Xue, Qian Li
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease, which is characterized by hyperandrogenism (HA), chronic anovulation, polycystic ovaries, insulin resistance and obesity. At present, the mechanism by which PCOS/HA occurs has not been fully elucidated, thus, the mechanisms behind and interventions for HA in PCOS are current hot topics in research. MiRNAs have recently been shown to serve as diagnostic or prognostic biomarkers in patients with cancer...
November 28, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29191698/micrornas-361-5p-and-mir-574-5p-associate-with-human-adipose-morphology-and-regulate-ebf1-expression-in-white-adipose-tissue
#19
Yasmina Belarbi, Niklas Mejhert, Hui Gao, Peter Arner, Mikael Rydén, Agné Kulyté
Reduced adipose expression of the transcription factor Early B cell factor 1 (EBF1) is linked to white adipose tissue (WAT) hypertrophy. We aimed to identify microRNAs (miRNAs) associated with WAT hypertrophy and EBF1 regulation. We mapped WAT miRNA expression from 26 non-obese women discordant in WAT morphology and determined EBF1 activity in the non-obese and 30 obese women. Expression of 15 miRNAs was higher in hypertrophy and 10 were predicted to target EBF1. Binding of miR-365-5p/miR-574-5p were validated with 3'-UTR assay...
November 27, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29186452/gender-and-cardiovascular-disease-are-sex-biased-mirna-networks-a-driving-force-behind-heart-failure-with-preserved-ejection-fraction-in-women
#20
Barend W Florijn, Roel Bijkerk, Eric van der Veer, Anton Jan van Zonneveld
CVD is the primary cause of death among men and women worldwide. Nevertheless, our comprehension of how CVD progresses in women and elicits clinical outcomes is lacking, leading CVD to be under-diagnosed and under-treated in women. A clear example of this differential presentation of CVD pathophysiologies in females is the strikingly higher prevalence of heart failure with preserved ejection fraction (HFpEF). Women with a history of preeclampsia, or those that present co-morbidities such as obesity, hypertension and diabetes mellitus are at increased risk to develop HFpEF...
November 24, 2017: Cardiovascular Research
keyword
keyword
10719
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"