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https://www.readbyqxmd.com/read/29344789/laparoscopic-conversion-in-colorectal-cancer-surgery-is-there-any-improvement-over-time-at-a-population-level
#1
Michael P M de Neree Tot Babberich, Julia T van Groningen, Evelien Dekker, Theo Wiggers, Michel W J M Wouters, Willem A Bemelman, Pieter J Tanis
Conversion of laparoscopic colorectal cancer resection has been associated with worse outcome, but this might have been related to a learning curve effect. This study aimed to evaluate incidence, predictive factors and outcomes of laparoscopic conversion after the implementation phase of laparoscopic surgery at a population level. Patients undergoing elective resection of non-locally advanced, non-metastatic colorectal cancer between 2011 and 2015 were included. Data were extracted from the Dutch Surgical Colorectal Audit...
January 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29340993/laparoscopic-assisted-modified-intersphincter-resection-for-ultralow-rectal-cancer
#2
Haiyang Zhou, Canping Ruan, Zhiguo Wang, Zhiqian Hu
BACKGROUND: Intersphincter resection (ISR) is considered to be a superior technique offering sphincter preservation in patients with ultralow rectal cancer.1 Because high-definition laparoscopy offers wider and clearer vision into the narrow pelvic cavity and intersphincteric space, ISR has been further refined.2 However, functional outcome after ISR has not been optimal. More than half of patients receiving ISR suffer partial or even complete anal incontinence.3 We therefore propose a laparoscopic-assisted modified ISR, with the aim of improving sphincter function following ISR...
January 16, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29338072/targeting-her2-in-colorectal-cancer-the-landscape-of-amplification-and-short-variant-mutations-in-erbb2-and-erbb3
#3
Jeffrey S Ross, Marwan Fakih, Siraj M Ali, Julia A Elvin, Alexa B Schrock, James Suh, Jo-Anne Vergilio, Shakti Ramkissoon, Eric Severson, Sugganth Daniel, David Fabrizio, Garrett Frampton, James Sun, Vincent A Miller, Philip J Stephens, Laurie M Gay
BACKGROUND: In contrast to lung cancer, few precision treatments are available for colorectal cancer (CRC). One rapidly emerging treatment target in CRC is ERBB2 (human epidermal growth factor receptor 2 [HER2]). Oncogenic alterations in HER2, or its dimerization partner HER3, can underlie sensitivity to HER2-targeted therapies. METHODS: In this study, 8887 CRC cases were evaluated by comprehensive genomic profiling for genomic alterations in 315 cancer-related genes, tumor mutational burden, and microsatellite instability...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29337962/the-relationship-between-right-sided-tumour-location-tumour-microenvironment-systemic-inflammation-adjuvant-therapy-and-survival-in-patients-undergoing-surgery-for-colon-and-rectal-cancer
#4
Meera Patel, Stephen T McSorley, James H Park, Campbell S D Roxburgh, Joann Edwards, Paul G Horgan, Donald C McMillan
BACKGROUND: There has been an increasing interest in the role of tumour location in the treatment and prognosis of patients with colorectal cancer (CRC), specifically in the adjuvant setting. Together with genomic data, this has led to the proposal that right-sided and left-sided tumours should be considered as distinct biological and clinical entities. The aim of the present study was to examine the relationship between tumour location, tumour microenvironment, systemic inflammatory response (SIR), adjuvant chemotherapy and survival in patients undergoing potentially curative surgery for stage I-III colon and rectal cancer...
January 16, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29337769/morbidity-following-coloanal-anastomosis-a-comparison-of-colonic-j-pouch-vs-straight-anastomosis
#5
Shaun Brown, David A Margolin, Laura K Altom, Heather Green, David E Beck, Brian R Kann, Charles B Whitlow, Herschel David Vargas
BACKGROUND: Low rectal tumors are often treated with sphincter-preserving resection followed by coloanal anastomosis. OBJECTIVE: The purpose of this study was to compare the short-term complications following straight coloanal anastomosis vs colonic J-pouch anal anastomosis. DESIGN: Patients were identified who underwent proctectomy for rectal neoplasia followed by coloanal anastomosis in the 2008 to 2013 American College of Surgeons National Surgical Quality Improvement Program database...
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29334918/colorectal-cancer-liver-metastases-a-population-based-study-on-incidence-management-and-survival
#6
Jennie Engstrand, Henrik Nilsson, Cecilia Strömberg, Eduard Jonas, Jacob Freedman
BACKGROUND: Colorectal cancer (CRC) is a leading cause of cancer-associated deaths with liver metastases developing in 25-30% of those affected. Previous data suggest a survival difference between right- and left-sided liver metastatic CRC, even though left-sided cancer has a higher incidence of liver metastases. The aim of the study was to describe the liver metastatic patterns and survival as a function of the characteristics of the primary tumour and different combinations of metastatic disease...
January 15, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29325357/-impact-of-primary-tumor-site-on-the-prognosis-in-different-stage-colorectal-cancer-patients-after-radical-resection
#7
J Han, X Zhang, A D Zhang, X L Zhou, L Feng, J Y Wang, G Y Wang
Objective: To analyze the effect to the prognosis of tumor site on the patients of colorectal cancer after curative resection with different stage. Methods: Clinicopathological and follow-up data of 2 097 colorectal carcinoma cases undergoing resection at Fourth Hospital of Hebei Medical University from January 2008 to March 2015 were retrospectively analyzed. There were 421 patients in left-sided colorectal cancer (LCC) group (including carcinoma in cecum, ascending colon , hepatic flexure, and transvers colon) , 386 in right-sided colorectal cancer (RCC) group (including carcinoma in splenic flexure, descending colon and sigmoid colon) and 1 290 in rectal cancer (RECC) group...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29316129/anastomotic-leakage-after-side-to-end-anastomosis-for-rectal-cancer-does-leakage-location-matter
#8
Elisabeth Hain, Léon Maggiori, Magaly Zappa, Justine Prost À la Denise, Yves Panis
AIM: To assess outcome according to location of anastomotic leakage (AL) after side-to-end stapler or manual low colorectal or coloanal anastomosis following laparoscopic total mesorectal excision (TME) for rectal cancer. METHODS: All patients presenting with symptomatic or asymptomatic AL after TME and side-to-end low anastomosis for rectal cancer performed from 2005 to 2014 were identified from our prospective database. CT-scans with contrast enema were reviewed to assess location of AL origin...
January 6, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29305784/preventing-parastomal-hernia-with-modified-stapled-mesh-stoma-reinforcement-technique-smart-in-patients-who-underwent-surgery-for-rectal-cancer-a-case-control-study
#9
A E Canda, C Terzi, C Agalar, T Egeli, C Arslan, C Altay, F Obuz
PURPOSE: Parastomal hernia is a frequent complication of an abdominal wall stoma. Surgical repairs have high complication and recurrence rates. Several different techniques have been suggested to prevent parastomal hernia during stoma creation. The aim of the present case-control study was to evaluate the efficacy of modified Stapled Mesh stomA Reinforcement Technique (SMART) for prevention of parastomal hernia compared with conventional colostomy formation in patients who underwent open or laparoscopic rectal resection and end colostomy for cancer...
January 5, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29304229/cd16-macrophages-mediate-fibrosis-in-inflammatory-bowel-disease
#10
Pedro Salvador, Dulce Carolina Macías-Ceja, Laura Gisbert-Ferrándiz, Carlos Hernández, David Bernardo, Rafael Alós, Francisco Navarro-Vicente, Juan Vicente Esplugues, Dolores Ortiz-Masiá, Maria Dolores Barrachina, Sara Calatayud
Background and aims: Fibrosis is a common complication of Crohn's disease, and is related with dysregulated tissular repair following inflammation, in which macrophages play a central role. We have previously observed that STAT6-/- mice present delayed mucosal recovery after TNBS-induced colitis due to a deficiency in reparatory IL4/STAT6-dependent M2 macrophages, which can be reverted by the exogenous transfer of this cell type. In the present study we aimed to analyze the role of STAT6-dependent macrophages in intestinal fibrosis...
January 3, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29300814/body-mass-index-and-20-specific-cancers-re-analyses-of-dose-response-meta-analyses-of-observational-studies
#11
E K Choi, H B Park, K H Lee, J H Park, M Eisenhut, H J van der Vliet, G Kim, J I Shin
Background: Objectives were to provide an overview and understand the strength of evidence and extent of potential biases and validity of claimed associations between Body Mass Index (BMI) and risk of developing cancer. Methods: We performed an umbrella review and comprehensively re-analysed the data of dose-response meta-analyses on associations between BMI and risk of 20-specific cancers (bladder, brain, breast, colonic, rectal, endometrial, gallbladder, gastric, leukemia, liver, lung, melanoma, multiple myeloma, non-Hodgkins lymphoma, oesophagus, ovarian, pancreatic, prostate, renal, thyroid) by adding big data or missed individual studies...
December 28, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29299358/pacritinib-to-inhibit-jak-stat-signaling-in-refractory-metastatic-colon-and-rectal-cancer
#12
Thomas Regenbogen, Ling Chen, Kathryn Trinkaus, Andrea Wang-Gillam, Benjamin R Tan, Manik Amin, Katrina S Pedersen, Haeseong Park, Rama Suresh, Kian-Huat Lim, Emily Ratchford, Amberly Brown, A Craig Lockhart
Background: Treatment options for patients with refractory colorectal cancer are limited and typically provide a chance of only modest benefit. The goal of this study was to evaluate the benefit of inhibiting the JAK/STAT inflammatory pathway with single agent pacritinib in patients with metastatic refractory colorectal adenocarcinoma. Methods: A single arm institutional trial was initiated and enrolled patients with metastatic colorectal cancer refractory to at least two standard lines of treatment...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29286030/-urgent-surgical-care-for-patients-with-colon-cancer-complicated-by-hemorrhage
#13
A V Shabunin, Z A Bagateliya, I Yu Korzheva, S S Lebedev
AIM: To evaluate an effectiveness of various hemostatic methods in patients with colon and rectal cancer. MATERIAL AND METHODS: 77 urgent patients with colon and rectal cancer complicated by bleeding were enrolled. Medication was effective in 11 patients (group 1), endoscopic hemostasis in 47 patients (group 2), vascular embolization in 2 cases (group 3), internal iliac arteries ligation in 2 patients (group 4), 15 patients underwent emergency resection (group 5)...
2017: Khirurgiia
https://www.readbyqxmd.com/read/29280120/-clinical-application-of-compound-anastomotic-device-in-protective-terminal-ileostomy-during-rectal-cancer-operation
#14
Qi Huang, Feng Cao, Jinzhe Zhou, Liming Liu, Bujun Ge
OBJECTIVE: To investigate the clinical effect of the application of "compound anastomotic device" on the high-risk colorectal anastomosis in rectal cancer patients undergoing protective ileostomy. METHODS: A total of 116 rectal cancer patients undergoing surgical procedure and prophylactic ileostomy in Tongji Hospital (90 cases) and The Third People's Hospital of Jingdezhen City (26 cases) from May 2011 to October 2016 were prospectively enrolled in the study. Paralleled control study and random digital table were applied...
December 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29277623/molecular-mechanistic-pathway-of-colorectal-carcinogenesis-associated-with-intestinal-microbiota
#15
REVIEW
Paramita Mandal
The colon rectal portion of gastrointestinal tract (GI) is full of microorganisms with different complex community that plays important role in maintaining homeostasis. But now-a-days different literature indicated that microbiota cause development of colorectal cancer (CRC) with a disease and ultimately aggravates to death. The mechanism inside the colo-rectal portion of GI tract is not fully well-known and bacterial contribution inside it is also fully unclear. Therefore, there is certain evidence trying a target about the unclear mechanism between intestinal microbiota and CRC...
December 19, 2017: Anaerobe
https://www.readbyqxmd.com/read/29277562/evaluating-the-expression-level-of-co-stimulatory-molecules-cd-80-and-cd-86-in-different-types-of-colon-polyps
#16
N Peyravian, E Gharib, A Moradi, M Mobahat, P Tarban, P Azimzadeh, E Nazemalhosseini-Mojarad, H Asadzadeh Aghdaei
PURPOSE OF THE STUDY: Co-stimulatory molecules CD80 and CD86 are the members of B7 family, which stimulate the T lymphocytes in response to the malignant colon polyps. However, the expression of these molecules is depressed in cancers. In the present study, the transcription levels of CD80 and CD86 genes in the colon polyps (Precancerous lesions) and its association with the clinical features were examined. PATIENTS AND METHODS: Forty-nine biopsies samples from patients with the colorectal polyps and 10 healthy subjects were collected by the colonoscopy...
December 22, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29275667/trends-in-presentation-treatment-and-survival-of-1777-patients-with-colorectal-cancer-over-a-decade-a-biobank-study
#17
Eetu Heervä, Anu Carpelan, Samu Kurki, Jari Sundström, Heikki Huhtinen, Arto Rantala, Annika Ålgars, Raija Ristamäki, Olli Carpén, Heikki Minn
BACKGROUND: Most survival data in colorectal cancer (CRC) is derived from clinical trials or register-based studies. Hospital Biobanks, linked with hospital electronic records, could serve as a data-gathering method based on consecutively collected tumor samples. The aim of this Biobank study was to analyze survival of colorectal patients diagnosed and treated in a single-center university hospital over a period of 12 years, and to evaluate factors contributing to outcome. MATERIAL AND METHODS: A total of 1777 patients with CRC treated during 2001-2012 were identified from the Auria Biobank, Turku, Finland...
December 23, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29238222/the-burden-of-selected-cancers-in-the-us-health-behaviors-and-health-care-resource-utilization
#18
Laura Iadeluca, Jack Mardekian, Pratibha Chander, Markay Hopps, Geoffrey T Makinson
Objective: To characterize the disease burden among survivors of those cancers having the highest incidence in the US. Methods: Adult (≥18 years) survivors of the 11 most frequently diagnosed cancers were identified from publically available data sources, including the Surveillance Epidemiology and End Results 9 1973-2012, National Health Interview Survey 2013, and the Medical Expenditure Panel Survey 2011. Chi-square tests and one-way analyses of variance were utilized to assess differences between cancer survivors and non-cancer controls in behavioral characteristics, symptoms and functions, preventative screenings, and health care costs...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29234589/retrospective-study-of-predictors-of-bone-metastasis-in-colorectal-cancer-patients
#19
Zhenghong, Zihua Zhu, Guoweijian, Zhangning, Caiyunyun, Yingjiangshan, Xiaomi
Background: We explored risk factors for bone metastasis (BMs) in colorectal cancer (CRC) to improve in early diagnosis and follow-up and to reduce bone metastasis. Methods: With a retrospective analysis of 2066 patients with CRC treated in our institution from January 2006 to January 2015, we assessed high-risk variables associated with bone metastasis using univariate and multivariate analyses. Results: Of those subjects studied, 102 patients developed BMs, including 62 of 1014 the rectal cancer patients and 40 of the 1052 colon cancer patients...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29225701/cytotoxic-escherichia-coli-strains-encoding-colibactin-and-cytotoxic-necrotizing-factor-cnf-colonize-laboratory-macaques
#20
Yan Feng, Anthony Mannion, Carolyn M Madden, Alton G Swennes, Catherine Townes, Charles Byrd, Robert P Marini, James G Fox
Background: Many Escherichia coli strains are considered to be a component of the normal flora found in the human and animal intestinal tracts. While most E. coli strains are commensal, some strains encode virulence factors that enable the bacteria to cause intestinal and extra-intestinal clinically-relevant infections. Colibactin, encoded by a genomic island (pks island), and cytotoxic necrotizing factor (CNF), encoded by the cnf gene, are genotoxic and can modulate cellular differentiation, apoptosis and proliferation...
2017: Gut Pathogens
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