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https://www.readbyqxmd.com/read/28739176/digital-rectal-examination-for-prostate-cancer-screening-performed-with-colonoscopy-for-colon-cancer-screening-two-for-the-price-of-one
#1
John C Fang, Gary Faerber, Jewel Samadder
No abstract text is available yet for this article.
July 21, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28739093/individual-surgeon-is-an-independent-risk-factor-for-leak-after-double-stapled-colorectal-anastomosis-an-institutional-analysis-of-800-patients
#2
Eduardo García-Granero, Francisco Navarro, Carlos Cerdán Santacruz, Matteo Frasson, Alvaro García-Granero, Franco Marinello, Blas Flor-Lorente, Alejandro Espí
BACKGROUND: Our aim was to assess whether the individual surgeon is an independent risk factor for anastomotic leak in double-stapled colorectal anastomosis after left colon and rectal cancer resection. METHODS: This retrospective analysis of a prospectively collected database consists of a consecutive series of 800 patients who underwent an elective left colon and rectal resection with a colorectal, double-stapled anastomosis between 1993 and 2009 in a specialized colorectal unit of a tertiary hospital with 7 participating surgeons...
July 21, 2017: Surgery
https://www.readbyqxmd.com/read/28736986/adolescent-body-mass-index-and-risk-of-colon-and-rectal-cancer-in-a-cohort-of-1-79-million-israeli-men-and-women-a-population-based-study
#3
Zohar Levi, Jeremy D Kark, Lior H Katz, Gilad Twig, Estela Derazne, Dorit Tzur, Yaara Leibovici Weissman, Adi Leiba, Irena Lipshiez, Lital Keinan Boker, Arnon Afek
BACKGROUND: This study examined the association between the body mass index (BMI) in late adolescence and the risk of colon and rectal cancer. METHODS: This study analyzed a cohort of 1,087,358 Jewish men and 707,212 Jewish women who underwent health examinations at the ages of 16 to 19 years between 1967 and 2002 and were followed by linkage to the national cancer registry up to 2012. Cox regression was used to estimate hazard ratios (HRs) for cancer according to age- and sex-adjusted BMI percentiles from the US Centers for Disease Control and Prevention (overweight, 85th percentile to <95th percentile; obesity, ≥95th percentile)...
July 24, 2017: Cancer
https://www.readbyqxmd.com/read/28736641/bone-marrow-tolerance-during-postoperative-chemotherapy-in-colorectal-carcinomas
#4
Neil B Newman, Rebecca A Moss, Nell Maloney-Patel, Kristen Donohue, Teresa V Brown, Michael J Nissenblatt, Shou-En Lu, Salma K Jabbour
BACKGROUND: This study seeks to quantify and compare bone marrow tolerance during postoperative chemotherapy therapy between rectal cancer vs. colon cancer patients. During rectal cancer treatment, patients receive neoadjuvant chemoradiation (CRT) irradiation which can exacerbate the hematologic toxicity (HT) via incidental irradiation of the pelvic bone marrow (PBM) during myelosuppressive postoperative chemotherapy. In contrast, colon cancer patients receive the same postoperative myelosuppressive chemotherapy but do not routinely receive preoperative chemoradiation therapy...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28736640/systematic-review-and-a-meta-analysis-of-hospital-and-surgeon-volume-outcome-relationships-in-colorectal-cancer-surgery
#5
Ya Ruth Huo, Kevin Phan, David L Morris, Winston Liauw
BACKGROUND: Numerous hospitals worldwide are considering setting minimum volume standards for colorectal surgery. This study aims to examine the association between hospital and surgeon volume on outcomes for colorectal surgery. METHODS: Two investigators independently reviewed six databases from inception to May 2016 for articles that reported outcomes according to hospital and/or surgeon volume. Eligible studies included those in which assessed the association hospital or surgeon volume with outcomes for the surgical treatment of colon and/or rectal cancer...
June 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28735581/independent-associations-of-dairy-and-calcium-intakes-with-colorectal-cancers-in-the-adventist-health-study-2-cohort
#6
Yessenia Tantamango-Bartley, Synnove F Knutsen, Karen Jaceldo-Siegl, Jing Fan, Andrew Mashchak, Gary E Fraser
OBJECTIVE: Results associating dairy and Ca intakes with colorectal cancer (CRC) risk have been mixed. Most previous analyses have suffered from confounding between dairy and Ca intakes. We examined independent associations between these variables, also dairy foods, and CRC incidence in a population with a large range of dairy intakes. DESIGN: Adventist Health Study-2 is a cohort study where subjects were enrolled 2002-2007. Proportional hazard regression analyses were performed to estimate hazard ratios (HR)...
July 24, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28732371/the-impacts-of-surgery-of-the-primary-cancer-and-radiotherapy-on-the-survival-of-patients-with-metastatic-rectal-cancer
#7
Duo Tong, Fei Liu, Wenhua Li, Wen Zhang
The role of surgery of the primary cancer and radiation in metastatic colorectal cancer (mCRC) is still controversial currently, and evidence implied that colon cancer (CC) and rectal cancer (RC) should be treated with difference. Hence we focused on metastatic rectal cancer (mRC) solely to compare the cancer cause-specific survival (CSS) of patients receiving varied treatments of the primary cancer: no treatment, surgery only, radiation only, and surgery plus radiation, based on the records of the Surveillance, Epidemiology, and End Results (SEER) database...
July 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28732363/meta-analysis-of-the-association-between-the-inflammatory-potential-of-diet-and-colorectal-cancer-risk
#8
Yu Fan, Xin Jin, Changfeng Man, Zhenjun Gao, Xiaoyan Wang
OBJECTIVES: The inflammatory potential of diet has been inconsistently linked to colorectal cancer (CRC) risk. This meta-analysis aimed to evaluate the association of the inflammatory potential of diet, as estimated by the dietary inflammatory index (DII) score, with CRC risk. MATERIALS AND METHODS: The PubMed and Embase databases were searched for relevant studies from inception to February 2017. All cohort and case-control studies investigating the association of the DII score with CRC risk were selected...
July 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28731950/totally-laparoscopic-resection-for-low-sigmoid-and-rectal-cancer-using-natural-orifice-specimen-extraction-techniques
#9
Hideharu Shimizu, Kensuke Adachi, Hideo Ohtsuka, Itaru Osaka, Kunio Takuma, Kijuro Takanishi, Jun Matsumoto
BACKGROUND: A minilaparotomy for specimen extraction during laparoscopy occasionally results in postoperative wound complications. We have performed a totally laparoscopic resection for early colorectal cancer using the natural orifice specimen extraction technique. METHODS: From 2008 to 2013, we have performed a totally laparoscopic resection for clinical stage I and IIA low sigmoid colon and rectal cancers. A prospectively maintained database was reviewed to assess the outcomes after surgery...
July 20, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28720424/participation-of-colon-and-rectal-fellows-in-robotic-rectal-cancer-surgery-effect-on-surgical-outcomes
#10
Danielle Collins, Nikolaos Machairas, Emilie Duchalais, Ron G Landmann, Amit Merchea, Dorin T Colibaseanu, Scott R Kelley, Kellie L Mathis, Eric J Dozois, David W Larson
OBJECTIVES: To determine whether involvement of colon and rectal fellows has an effect on short-term surgical and oncological outcomes in robotic rectal cancer surgery. PATIENTS AND METHODS: From a dataset of 263 robotic-assisted rectal cancer operations, 114 case-matched patients over a 5-year period (January 2010-December 2015) were included in the study. Patients who underwent resection with and without fellow involvement were compared. Cases were matched according to age, body mass index, neoadjuvant therapy, and tumor location...
July 15, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28717897/development-of-a-fast-and-cost-effective-gas-chromatography-mass-spectrometry-method-for-the-quantification-of-short-chain-and-medium-chain-fatty-acids-in-human-biofluids
#11
Cesare Lotti, Josep Rubert, Francesca Fava, Kieran Tuohy, Fulvio Mattivi, Urska Vrhovsek
The quantification of short-chain and medium-chain fatty acids is becoming more and more relevant in fecal and plasma samples due to their biological impact, which has been associated with colon rectal cancer and fiber consumption. For these reasons, a fast, cost-effective, and reproducible analytical method is highly required. In this research, a gas chromatography-mass spectrometry method based on full scan and multiple reaction monitoring (MRM) acquisition modes were optimized and validated for the analysis of short-chain and medium-chain fatty acids in three biological samples: human fecal water, fecal fermentation supernatants, and human plasma...
July 17, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28717199/association-between-allergic-conditions-and-colorectal-cancer-risk-mortality-a-meta-analysis-of-prospective-studies
#12
Wangqian Ma, Jia Yang, Peiwei Li, Xinliang Lu, Jianting Cai
We aimed to assess the association between allergic conditions and risk/mortality of colorectal cancer (CRC). A systematic literature search was conducted using Pubmed and Embase to identify relevant studies. Prospective studies assessing the association between allergic conditions and risk/mortality of CRC were included. Risk ratios (RRs) were pooled with either a fixed- or a random-effects model according to heterogeneity. A total of 515379 participants and 10345 CRC cases from 12 studies were included in the analysis of CRC risk, while four studies with 1484741 individuals and 30040 CRC deaths were included in the analysis of CRC mortality...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710725/clinicopathologic-parameters-associated-with-postoperative-complications-and-risk-factors-for-tumor-recurrence-and-mortality-after-tumor-resection-of-patients-with-colorectal-cancer
#13
Z Bai, J Wang, T Wang, Y Li, X Zhao, G Wu, Y Yang, W Deng, Z Zhang
OBJECTIVE: To delineate the association of postoperative complications with clinicopathologic factors and to identify risk factors for tumor recurrence and mortality after tumor resection in patients with colorectal cancer (CRC). METHODS: The clinical data of 1144 patients with CRC who underwent surgical intervention between 2003 and 2013 were retrieved. Correlations of postoperative complications with clinicopathologic factors were examined using univariate analysis...
July 14, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28683006/height-and-risk-of-colorectal-cancer-a-meta-analysis
#14
Xinyuan Song, Xiuzhen Gong, Tong Zhang, Wenjie Jiang
Several epidemiological studies have investigated the relationship between height and risk of colorectal cancer (CRC), but the results were inconsistent. Thus, a meta-analysis of observational studies was carried out to clarify this association. A literature search was performed in PubMed and Web of Science databases for all relevant studies up to 25 May 2016. The random-effects model was used to calculate the pooled relative risks (RRs) and restricted cubic spline model was adopted for the dose-response analysis...
July 4, 2017: European Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28682966/management-of-low-colorectal-anastomotic-leakage-in-the-laparoscopic-era-more-than-a-decade-of-experience
#15
Stephen Alexander Boyce, Craig Harris, Andrew Stevenson, John Lumley, David Clark
BACKGROUND: Anastomotic leak after colorectal surgery increases postoperative mortality, cancer recurrence, permanent stoma formation, and poor bowel function. Anastomosis between the colon and rectum is a particularly high risk. Traditional management mandates laparotomy, disassembly of the anastomosis, and formation of an often-permanent stoma. After laparoscopic colorectal surgery it may be possible to manage anastomotic failure with laparoscopy, thus avoiding laparotomy. OBJECTIVE: The purpose of this study was to determine the feasibility of the laparoscopic management of failed low colorectal anastomoses...
August 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28677162/the-clinical-impact-of-tumour-infiltrating-lymphocytes-in-colorectal-cancer-differs-by-anatomical-subsite-a-cohort-study
#16
Jonna Berntsson, Maria C Svensson, Karin Leandersson, Björn Nodin, Patrick Micke, Anna H Larsson, Jakob Eberhard, Karin Jirström
Accumulating evidence demonstrates an association between dense infiltration of lymphocytes and prognosis in colorectal cancer (CRC), but whether this prognostic impact differs by tumour location remains unknown. This study investigated the prognostic impact of cytotoxic and regulatory T cells in CRC, with particular reference to the anatomical subsite of the primary tumour. The density of CD3(+) , CD8(+) , and FoxP3(+) tumour-infiltrating T cells was calculated in tissue microarrays with tumours from 557 incident CRC cases from a prospective population-based cohort...
July 5, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28677025/calcium-as-a-chemopreventive-agent-against-colorectal-neoplasm-does-obesity-play-a-role
#17
NaNa Keum, Hanseul Kim, Edward L Giovannucci
BACKGROUND: Concerning the chemopreventive potential of calcium against colorectal neoplasms, strong evidence from initial randomized controlled trials (RCTs) of colorectal adenoma has not been confirmed from the most recent large RCT. To explain the conflicting results, a new hypothesis was proposed that the benefit of calcium may be confined to lean individuals. METHODS: To test this hypothesis, we examined heterogeneity of the associations of calcium intake with adenoma and CRC, using data from the most recent meta-analyses of observational studies and conducting subgroup analysis by average body mass index (BMI) of study population...
July 4, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28676564/calcium-intake-and-risk-of-colorectal-cancer-according-to-expression-status-of-calcium-sensing-receptor-casr
#18
Wanshui Yang, Li Liu, Yohei Masugi, Zhi Rong Qian, Reiko Nishihara, NaNa Keum, Kana Wu, Stephanie Smith-Warner, Yanan Ma, Jonathan A Nowak, Fatemeh Momen-Heravi, Libin Zhang, Michaela Bowden, Teppei Morikawa, Annacarolina da Silva, Molin Wang, Andrew T Chan, Charles S Fuchs, Jeffrey A Meyerhardt, Kimmie Ng, Edward Giovannucci, Shuji Ogino, Xuehong Zhang
OBJECTIVE: Although evidence suggests an inverse association between calcium intake and the risk of colorectal cancer, the mechanisms remain unclear. The calcium-sensing receptor (CASR) is expressed abundantly in normal colonic epithelium and may influence carcinogenesis. We hypothesized that calcium intake might be associated with lower risk of CASR-positive, but not CASR-negative, colorectal cancer. DESIGN: We assessed tumour CASR protein expression using immunohistochemistry in 779 incident colon and rectal cancer cases that developed among 136 249 individuals in the Nurses' Health Study and Health Professionals Follow-Up Study...
July 4, 2017: Gut
https://www.readbyqxmd.com/read/28667784/transcription-factor-microrna-associations-and-their-impact-on-colorectal-cancer-survival
#19
Lila E Mullany, Jennifer S Herrick, Roger K Wolff, John R Stevens, Wade Samowitz, Martha L Slattery
MicroRNAs (miRNAs) and Transcription Factors (TFs) both influence messenger RNA (mRNA) expression, disrupting biological pathways involved in carcinogenesis and prognosis. As many miRNAs target multiple mRNAs, thus influencing a multitude of biological pathways, deciphering which miRNAs are important for cancer development and survival is difficult. In this study, we 1) determine associations between TF and survival (N = 168 colon cancer cases); 2) identify miRNAs associated with TFs related to survival; and 3) determine if factors derived from TF-specific miRNA principal component analysis (PCA) influence survival...
July 1, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28662634/healthy-dietary-patterns-decrease-the-risk-of-colorectal-cancer-in-the-mecca-region-saudi-arabia-a-case-control-study
#20
Firas S Azzeh, Eyad M Alshammari, Awfa Y Alazzeh, Abdelelah S Jazar, Ibrahim R Dabbour, Hani A El-Taani, Ahmed A Obeidat, Fayrooz A Kattan, Sufyan H Tashtoush
BACKGROUND: Colorectal cancer (CRC) is the first most common cancer in males and the third most common cancer in females in Saudi Arabia. Dietary habits are strongly associated with the inhibition or proliferation of malignancy. Therefore, this study is aiming to investigate the risks and protective benefits of dietary factors affecting CRC in the Mecca region of Saudi Arabia. METHODS: A case-control study was conducted from June 2014 to March 2015. One hundred thirty-seven patients with colon and/or rectal cancer were recruited in the case group, while 164 healthy participants were recruited in the control group...
June 29, 2017: BMC Public Health
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