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Arc and memory and refinement

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https://www.readbyqxmd.com/read/25589774/long-delayed-expression-of-the-immediate-early-gene-arc-arg3-1-refines-neuronal-circuits-to-perpetuate-fear-memory
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Daisuke Nakayama, Hirokazu Iwata, Chie Teshirogi, Yuji Ikegaya, Norio Matsuki, Hiroshi Nomura
Fear memories typically persist for long time periods, and persistent fear memories contribute to post-traumatic stress disorder. However, little is known about the cellular and synaptic mechanisms that perpetuate long-term memories. Here, we find that mouse hippocampal CA1 neurons exhibit biphasic Arc (also known as Arg3.1) elevations after fear experience and that the late Arc expression regulates the perpetuation of fear memoires. An early Arc increase returned to the baseline after 6 h, followed by a second Arc increase after 12 h in the same neuronal subpopulation; these elevations occurred via distinct mechanisms...
January 14, 2015: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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