keyword
https://read.qxmd.com/read/38529780/increased-rates-of-hospital-onset-staphylococcus-aureus-bacteraemia-in-national-health-service-acute-trusts-in-england-between-june-2020-and-march-2021-a-national-surveillance-review
#1
JOURNAL ARTICLE
E Mason, O Nsonwu, J Elmes, D Chudasama, C Pearson, L Hasan, R Hope, S M Gerver
A large increase in hospital-onset and intensive-care-unit-onset Staphylococcus aureus bacteraemia rates in English acute trusts was observed between 2020 and 2021, coinciding with reported increases in coronavirus disease (COVID-19) cases and associated hospitalizations. Many of these S. aureus bacteraemia cases were defined as co-/secondary infections to COVID-19. Over the same period, increases in the percentage of ventilator-associated pneumonia-related bacteraemia were also found. The COVID-19 pandemic appears to have contributed to the increase in hospital-onset S...
January 2024: Journal of Hospital Infection
https://read.qxmd.com/read/38524181/a-comparative-study-of-genotyping-and-antimicrobial-resistance-between-carbapenem-resistant-klebsiella-pneumoniae-and-acinetobacter-baumannii-isolates-at-a-tertiary-pediatric-hospital-in-china
#2
JOURNAL ARTICLE
Xiaoli Jian, Yunyun Li, Haiping Wang, Cuilian Li, Feng Li, Jue Li, Jing Dong, Tingyi Du, Li Jiang
BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) clinical isolations have rapidly increased in pediatric patients. To investigate a possible health care-associated infections of CRKP in a tertiary pediatric hospital, the circulating clones and carbapenem-resistant pattern between CRKP and carbapenem-resistant Acinetobacter baumannii (CRAB) isolates were compared to classify their epidemiological characteristics. The results will help to identify the epidemic pattern of the CRKP transmission in the hospital...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38522443/effectiveness-of-bubble-continuous-positive-airway-pressure-for-treatment-of-children-aged-1-59-months-with-severe-pneumonia-and-hypoxaemia-in-ethiopia-a-pragmatic-cluster-randomised-controlled-trial
#3
JOURNAL ARTICLE
Meseret Gebre, Kassa Haile, Trevor Duke, Md Tanveer Faruk, Mehnaz Kamal, Md Farhad Kabir, Md Fakhar Uddin, Muluye Shimelis, Tigist Beyene, Bethelhem Solomon, Meles Solomon, Abebe Genetu Bayih, Alemseged Abdissa, Taye Tolera Balcha, Rahel Argaw, Asrat Demtse, Abate Yeshidinber Weldetsadik, Abayneh Girma, Bitseat W Haile, Abu Sadat Mohammad Sayeem Bin Shahid, Tahmeed Ahmed, John D Clemens, Mohammod Jobayer Chisti
BACKGROUND: The safety and efficacy of bubble continuous positive airway pressure (bCPAP) for treatment of childhood severe pneumonia outside tertiary care hospitals is uncertain. We did a cluster-randomised effectiveness trial of locally made bCPAP compared with WHO-recommended low-flow oxygen therapy in children with severe pneumonia and hypoxaemia in general hospitals in Ethiopia. METHODS: This open, cluster-randomised trial was done in 12 general (secondary) hospitals in Ethiopia...
March 21, 2024: Lancet Global Health
https://read.qxmd.com/read/38517643/impact-of-healthcare-associated-infections-within-7-days-of-acute-stroke-on-health-outcomes-and-risk-of-care-dependency-a-multi-centre-registry-based-cohort-study
#4
JOURNAL ARTICLE
David Fluck, Christopher H Fry, Jonathan Robin, Brendan Affley, Puneet Kakar, Pankaj Sharma, Thang S Han
Healthcare-associated infections (HCAIs) in patients admitted with acute conditions remain a major challenge to healthcare services. Here, we assessed the impact of HCAIs acquired within 7-days of acute stroke on indicators of care-quality outcomes and dependency. Data were prospectively collected (2014-2016) from the Sentinel Stroke National Audit Programme for 3309 patients (mean age = 76.2 yr, SD = 13.5) admitted to four UK hyperacute stroke units (HASU). Associations between variables were assessed by multivariable logistic regression (odds ratios, 95% confidence intervals), adjusted for age, sex, co-morbidities, pre-stroke disability, swallow screening, stroke type and severity...
March 22, 2024: Internal and Emergency Medicine
https://read.qxmd.com/read/38516897/-covid-19-readmissions-during-the-first-three-epidemic-periods-in-orihuela-spain-incidence-risk-factors-and-letality
#5
JOURNAL ARTICLE
Nuria Roig-Sánchez, Alberto Talaya Peñalver, Noemí Poveda Ruiz, Alfonso Del Pozo, Ana María Hernández Campillo, Alicia Pérez Bernabéu, Belén Martínez-López, Inmaculada González-Cuello, María García-López, Emilio Borrajo Brunete, Philip Wikman-Jorgensen, Jara Llenas-García
OBJECTIVE: Readmission for COVID-19 is associated with high mortality, saturation of health services, and high costs. This study aimed to assess the incidence and risk factors of readmissions in COVID-19 patients in a regional hospital of Spain from February 2020 to March 2021. METHODS: A retrospective cohort study describing the characteristics of adult patients readmitted within thirty days of discharge after being infected with SARS-CoV-2 was carried out. Readmission associated risk factors were analysed using a binary logistic regression model...
March 19, 2024: Revista Española de Salud Pública
https://read.qxmd.com/read/38514151/predictors-of-recovery-time-from-severe-community-acquired-pneumonia-among-paediatrics-patients-in-selected-hospitals-in-addis-ababa-ethiopia-an-institution-based-retrospective-cohort-study
#6
JOURNAL ARTICLE
Kalkidan Mekonnen Sinishaw, Girum Sebsbie, Mekonen Adimasu Kebede
OBJECTIVE: Severe community-acquired pneumonia (SCAP) is a significant cause of morbidity worldwide and a major cause of morbidity and mortality in developing countries. Ethiopia ranks 6th out of 15 countries with the highest mortality rate due to pneumonia in children under 5 years of age. The aim of this study was to determine the recovery time from SCAP and factors in paediatric patients in selected hospitals in Addis Ababa. DESIGN, PARTICIPANTS AND SETTING: A retrospective cohort study was conducted among 407 randomly selected paediatric patients admitted with SCAP in Addis Ababa public hospitals from 1 January 2018 to 31 December 2020...
March 21, 2024: BMJ Open
https://read.qxmd.com/read/38511126/nebulized-furosemide-for-pulmonary-inflammation-in-intubated-patients-with-covid-19-a-phase-2-randomized-controlled-double-blind-study
#7
JOURNAL ARTICLE
John Muscedere, David M Maslove, Christopher J Barden, Donald F Weaver, J Gordon Boyd, Stephanie Sibley, Tracy Boyd, Oleksa Rewa, Martin Albert, Marios Roussos, Patrick A Norman, Andrew G Day
OBJECTIVES: Respiratory failure secondary to COVID-19 is associated with morbidity and mortality. Current anti-inflammatory therapies are effective but are given systemically and have significant side effects. Furosemide has anti-inflammatory properties, can be administered by inhalation, and is inexpensive. We investigated the efficacy of nebulized furosemide as an adjunctive therapy for COVID-19 respiratory failure. DESIGN: A double-blind, randomized, placebo-controlled trial...
February 2024: Critical care explorations
https://read.qxmd.com/read/38510774/audit-on-practices-of-endotracheal-suctioning-in-intensive-care-unit-patients-among-health-care-workers-hcws
#8
JOURNAL ARTICLE
Rahil Singh, Anju Romina Bhalotra, Shubhangi Sharma
BACKGROUND: Endotracheal suctioning (ETS) is one of the most frequently performed invasive procedures in intensive care units (ICUs). This audit was aimed at studying current practices and knowledge regarding ETS in the Indian critical care setup, with the background aim of raising awareness regarding correct practices as per current recommendations in critically ill patients. MATERIALS AND METHODS: After registering the trial with the clinical trial registry, India, a structured audit questionnaire containing 20 questions pertaining to ETS was distributed through electronic media among resident doctors working in the ICUs across India...
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38510743/the-interplay-between-sars-cov-2-infection-related-cardiovascular-diseases-and-depression-common-mechanisms-shared-symptoms
#9
REVIEW
Ana Gonjilashvili, Sophio Tatishvili
In 2020 the World Health organization announced a pandemic due to the outbreak of the Coronavirus disease 19. Pneumonia was the most common manifestation of the Sars-Cov-2 infection, however, clinical papers describe Sars-Cov-2 associated cardiovascular pathologies, such as ACS, myopericarditis, cardiomyopathies, dysrhythmias, as leading causes of increased morbidity and mortality. The short and long term prognosis of Sars-Cov-2-related cardiovascular diseases was defined not only by the disease severity itself but also by associated conditions and complications, among which mental health issues (stress, depression and anxiety) have a negative impact...
February 2024: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38506533/outbreak-of-ndm-5-producing-klebsiella-pneumoniae-st307-an-emerging-high-risk-antimicrobial-resistance-clone-in-shanghai-china
#10
JOURNAL ARTICLE
Junying Zhu, Guangyu Wang, Min Li
The high-risk clone Klebsiella pneumoniae ST307, associated with various carbapenem resistance genes, exhibits a global distribution and prevalence. However, in China, it has remained sporadic and has rarely been detected. In this study, we reported an outbreak caused by nine ST307 CRKP isolates harboring bla NDM-5 in Shanghai, China, in 2022. We employed antimicrobial susceptibility testing, conjugation assay, whole-genome sequencing (WGS) and comparative genomics, phylogenetic analysis, and fitness and virulence comparison to further characterize the isolates causing the outbreak...
March 20, 2024: MSystems
https://read.qxmd.com/read/38505992/oral-hygiene-in-critically-ill-patients-at-a-tertiary-hospital-in-s%C3%A3-o-paulo-brazil-a-best-practice-implementation-project
#11
JOURNAL ARTICLE
Mariana Davies Ribeiro Bersaneti, Renata Desordi Lobo, Thais Bianca Brandão, Regina Claudia Silva Souza, Vanessa de Brito Poveda
OBJECTIVES: This project aimed to promote evidence-based practices relat. ed to the oral health of critically ill patients in an intensive care unit in Brazil. INTRODUCTION: The oral hygiene of patients on mechanical ventilation is an essential component of nursing care quality, and well-defined guidelines ensure appropriate care. Mechanical ventilation is associated with the risk of ventilator-associated pneumonia, which can increase mortality, length of stay, time on mechanical ventilation, and hospital costs...
March 21, 2024: JBI evidence implementation
https://read.qxmd.com/read/38503661/vaccine-value-profile-for-klebsiella-pneumoniae
#12
JOURNAL ARTICLE
Ziyaad Dangor, Nicole Benson, James A Berkley, Julia Bielicki, Merijn W Bijsma, Jonathan Broad, Ed T Buurman, Alan Cross, Erin M Duffy, Kathryn E Holt, Pui-Ying Iroh Tam, Mark Jit, Konstantinos Karampatsas, Michael Katwere, Gaurav Kwatra, Ramanan Laxminarayan, Kirsty Le Doare, Robert Mboizi, Francesca Micoli, Catrin E Moore, Eve Nakabembe, Nichola R Naylor, Seamus O'Brien, Courtney Olwagen, Denasha Reddy, Charlene Rodrigues, David A Rosen, Manish Sadarangani, Padmini Srikantiah, Sharon M Tennant, Mateusz Hasso-Agopsowicz, Shabir A Madhi
Klebsiella pneumoniae causes community- and healthcare-associated infections in children and adults. Globally in 2019, an estimated 1.27 million (95% Uncertainty Interval [UI]: 0.91-1.71) and 4.95 million (95% UI: 3.62-6.57) deaths were attributed to and associated with bacterial antimicrobial resistance (AMR), respectively. K. pneumoniae was the second leading pathogen in deaths attributed to AMR resistant bacteria. Furthermore, the rise of antimicrobial resistance in both community- and hospital-acquired infections is a concern for neonates and infants who are at high risk for invasive bacterial disease...
March 18, 2024: Vaccine
https://read.qxmd.com/read/38497333/association-of-pneumonia-admission-with-polypharmacy-and-drug-use-in-community-dwelling-older-people
#13
JOURNAL ARTICLE
Hironobu Hamaya, Taro Kojima, Yukari Hattori, Masahiro Akishita
AIM: The purpose of the present study was to clarify the association of pneumonia admission with polypharmacy and specific drug use in community-dwelling older people. METHODS: Using health insurance and long-term care insurance data from Kure city in Japan, we retrospectively collected data for older community-dwelling people (aged ≥65 years) from April 2017 to March 2019. The outcome was pneumonia admission. We carried out multivariate logistic regression analysis to identify the association of pneumonia admission with polypharmacy (≥5 drugs), the use of psychotropic drugs or anticholinergics with adjustment for patient backgrounds, such as comorbidity, and the daily life independence level for the older people with disability...
March 18, 2024: Geriatrics & Gerontology International
https://read.qxmd.com/read/38494251/emergence-of-carbapenem-resistant-gram-negative-pathogens-with-high-rate-of-colistin-resistance-in-egypt-a-cross-sectional-study-to-assess-resistance-trends-during-the-covid-19-pandemic
#14
JOURNAL ARTICLE
Fatma A Afify, Ahmed H Shata, Nirmeen Aboelnaga, Dina Osama, Salma W Elsayed, Nehal A Saif, Shaimaa F Mouftah, Sherine M Shawky, Ahmed A Mohamed, Omar Loay, Mohamed Elhadidy
The current study investigated the temporal phenotypic and genotypic antimicrobial resistance (AMR) trends among multi-drug resistant and carbapenem-resistant Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa recovered from Egyptian clinical settings between 2020 and 2021. Bacterial identification and antimicrobial sensitivity of 111 clinical isolates against a panel of antibiotics were performed. Molecular screening for antibiotic resistance determinants along with integrons and associated gene cassettes was implemented...
March 2024: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/38488792/clinicians-who-practice-primarily-in-nursing-homes-and-the-quality-of-end-of-life-care-among-residents
#15
JOURNAL ARTICLE
Arnab K Ghosh, Mark Aaron Unruh, Hyunkyung Yun, Hye-Young Jung
IMPORTANCE: Clinician specialization in the care of nursing home (NH) residents or patients in skilled nursing facilities (SNFs) has become increasingly common. It is not known whether clinicians focused on NH care, often referred to as SNFists (ie, physicians, nurse practitioners, and physician assistants concentrating their practice in the NH or SNF setting), are associated with a reduced likelihood of burdensome transitions in the last 90 days of life for residents, which are a marker of poor-quality end-of-life (EOL) care...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38485249/comorbidities-associated-with-adult-asthma-a-population-based-matched-cohort-study-in-finland
#16
JOURNAL ARTICLE
Riikka Emilia Lemmetyinen, Sanna Katriina Toppila-Salmi, Anna But, Risto Renkonen, Juha Pekkanen, Jari Haukka, Jussi Karjalainen
BACKGROUND: Asthma is a common chronic disease characterised by variable respiratory symptoms and airflow limitation, affecting roughly 4%-10% of the adult population. Adult asthma is associated with higher all-cause mortality compared to individuals without asthma. In this study, we investigate the comorbidities that may affect the management of asthma. METHODS: Total of 1648 adults with asthma and 3310 individuals without asthma aged 30-93 were matched with age, gender and area of residency, and followed from 1 January 1997 to 31 December 2013...
March 14, 2024: BMJ Open Respiratory Research
https://read.qxmd.com/read/38482272/spectrum-of-pathogens-and-their-antimicrobial-susceptibility-pattern-isolated-from-bronchoalveolar-lavage-specimens-at-a-hilly-area-in-uttarakhand
#17
JOURNAL ARTICLE
Nidhi Negi, Pankaj Rawat, Iva Chandola, Uneza Husain, Ketan Priyadarshi
BACKGROUND: Lower respiratory tract infections (LRTIs) are associated with significant morbidity and mortality in all age groups, especially young children and the elderly population. Various gram-positive and gram-negative organisms such as Streptococcus spp., Pseudomonas spp., and Klebsiella spp. have been implicated as a pathogen in bronchoalveolar lavage (BAL) specimens collected from such patients. AIMS AND RATIONALE OF THE STUDY: The present study is aimed at assessing the spectrum of the bacterial isolates and determining the antimicrobial resistance obtained from the BAL fluid from admitted patients at various wards and intensive care units (ICUs) of a tertiary care hospital in Dehradun...
January 2024: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38481522/risk-of-serious-bacterial-infections-in-pediatric-patients-with-hyperpyrexia
#18
JOURNAL ARTICLE
Sofia Rachad, Dane Nickel, Fiona Berry, Meghan Goddard, Ayesha Khan, Natalie Muratori, Saul Hymes, Ashar Ata, Christopher Woll
OBJECTIVES: Hyperpyrexia has been associated with a greater prevalence of bacterial infections in the pediatric population, which prior to routine childhood vaccinations, has led to invasive testing and empiric antibiotic use for urinary tract infections, bacterial pneumonia, bacteremia, and bacterial meningitis. Since the implementation of routine childhood vaccinations, the prevalence of serious bacterial infections (SBIs) has declined. This study aims to determine if there is an association between hyperpyrexia and serious bacterial infections in well-appearing febrile pediatric patients presenting to the emergency department (ED)...
April 2024: Journal of the American College of Emergency Physicians open
https://read.qxmd.com/read/38480608/outcome-and-risk-of-poststroke-pneumonia-in-patients-with-acute-ischemic-stroke-after-endovascular-thrombectomy-a-post-hoc-analysis-of-the-direct-mt-trial
#19
JOURNAL ARTICLE
Ping Zhang, Lei Chen, Xiao-Fei Ye, Tao Wu, Ben-Qiang Deng, Peng-Fei Yang, Yi Han, Yong-Wei Zhang, Jian-Min Liu
BACKGROUND: In this study, we aimed to investigate the risk factors and impact of poststroke pneumonia (PSP) on mortality and functional outcome in patients with acute ischemic stroke (AIS) after endovascular thrombectomy (EVT). METHODS: This was a post hoc analysis of a prospective randomized trial (Direct intraarterial thrombectomy in order to revascularize AIS patients with large-vessel occlusion efficiently in Chinese tertiary hospitals: a multicenter randomized clinical trial)...
March 13, 2024: Neurocritical Care
https://read.qxmd.com/read/38478777/prediction-of-essential-proteins-of-klebsiella-pneumoniae-using-integrative-bioinformatics-and-systems-biology-approach-unveiling-new-avenues-for-drug-discovery
#20
JOURNAL ARTICLE
Gnanasekar Pranavathiyani, Archana Pan
Klebsiella pneumoniae is an opportunistic multidrug-resistant bacterial pathogen responsible for various health care-associated infections. The prediction of proteins that are essential for the survival of bacterial pathogens can greatly facilitate the drug development and discovery pipeline toward target identification. To this end, the present study reports a comprehensive computational approach integrating bioinformatics and systems biology-based methods to identify essential proteins of K. pneumoniae involved in vital processes...
March 13, 2024: Omics: a Journal of Integrative Biology
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