keyword
https://read.qxmd.com/read/38536827/effects-of-aflibercept-and-bevacizumab-on-cell-viability-cell-metabolism-and-inflammation-in-hypoxic-human-m%C3%A3-ller-cells
#1
JOURNAL ARTICLE
Monique Matsuda, Rafael André da Silva, Vinicius Moraes de Paiva Roda, Mônica Valéria Marquezini, Mário Luiz Ribeiro Monteiro, Dânia Emi Hamassaki
Anti-VEGF (vascular endothelial growth factor) drugs such as aflibercept (AFL) and bevacizumab (BVZ) inhibit pathological neo-angiogenesis and vascular permeability in retinal vascular diseases. As cytokines and growth factors are produced by Müller glial cells under stressful and pathological conditions, we evaluated the in vitro effect of AFL (Eylea®, 0.5 mg/mL) and BVZ (Avastin®, 0.5 mg/mL) on cell viability/metabolism, and cytokine/growth factor production by Müller cells (MIO-M1) under cobalt chloride (CoCl2)-induced hypoxia after 24h, 48h and 72h...
2024: PloS One
https://read.qxmd.com/read/38536564/metabolic-consequences-of-anabolic-steroids-insulin-and-growth-hormone-abuse-in-recreational-bodybuilders-implications-for-the-world-anti-doping-agency-passport
#2
JOURNAL ARTICLE
Filippo Giorgio Di Girolamo, Chiara Biasinutto, Alessandro Mangogna, Nicola Fiotti, Pierandrea Vinci, Rado Pisot, Filippo Mearelli, Bostjan Simunic, Chiara Roni, Gianni Biolo
BACKGROUND: Hormonal doping in recreational sports is a public-health concern. The World Anti-Doping Agency (WADA) promoted the creation of the Athlete Biological Passport, aiming to monitor athlete's biological variables over time to facilitate indirect detection of doping. Detection tests for anabolic androgenic steroids (AAS) and growth hormone (GH) are available while insulin abuse cannot be revealed. We have determined in recreational bodybuilders the metabolic effects associated with different patterns of hormone abuse...
March 27, 2024: Sports Medicine—Open
https://read.qxmd.com/read/38536545/early-sevoflurane-sedation-in-severe-covid-19-related-lung-injury-patients-a-pilot-randomized-controlled-trial
#3
JOURNAL ARTICLE
Beatrice Beck-Schimmer, Erik Schadde, Urs Pietsch, Miodrag Filipovic, Seraina Dübendorfer-Dalbert, Patricia Fodor, Tobias Hübner, Reto Schuepbach, Peter Steiger, Sascha David, Bernard D Krüger, Thomas A Neff, Martin Schläpfer
BACKGROUND: This study aimed to assess a potential organ protective effect of volatile sedation in a scenario of severe inflammation with an early cytokine storm (in particular IL-6 elevation) in patients suffering from COVID-19-related lung injury with invasive mechanical ventilation and sedation. METHODS: This is a small-scale pilot multicenter randomized controlled trial from four tertiary hospitals in Switzerland, conducted between April 2020 and May 2021. 60 patients requiring mechanical ventilation due to severe COVID-19-related lung injury were included and randomized to 48-hour sedation with sevoflurane vs...
March 27, 2024: Annals of Intensive Care
https://read.qxmd.com/read/38535440/a-standardized-extract-of-microalgae-phaeodactylum-tricornutum-mi136-inhibit-d-gal-induced-cognitive-dysfunction-in-mice
#4
JOURNAL ARTICLE
Jonathan Maury, Antoine Delbrut, Vanessa Villard, Rémi Pradelles
The microalgae Phaeodactylum tricornutum (PT) is distinguished by its rich nutrient profile, characterized by well-documented neuroprotective activities, including fucoxanthin (FX), a major carotenoid and polyunsaturated omega-3 fatty acids (n-3 PUFA). The current study aims to evaluate the protective effects of a standardized extract of PT (Mi136) containing 2% FX on cognitive function, oxidative stress, and inflammation parameters in a mouse model of accelerated aging. Seventy-two (72) male mice were randomly assigned to the blank control group (BC), negative control group (NC), and four similar microalgae extract of PT groups (branded as BrainPhyt™) with different human equivalent doses to evaluate potential dose-response effects...
February 21, 2024: Marine Drugs
https://read.qxmd.com/read/38535432/assessment-of-the-relationship-between-periodontitis-and-cardiac-parameters-in-patients-with-early-chronic-heart-failure-a-cross-sectional-study
#5
JOURNAL ARTICLE
Antina Schulze, Stefan Kwast, Christoph Pökel, Martin Busse
Periodontal disease (PD) is considered a risk factor for cardiovascular events. However, its relationship to chronic heart failure (CHF) is unclear. The aim was to compare cardiac and inflammatory parameters in CHF patients with (PG) versus without periodontitis (NPG). The following parameters were recorded in 58 patients: periodontal screening and recording (PSR), troponin T, NT-proBNP, C-reactive protein (CRP), interleukin-6 (IL-6), blood pressure, heart rate, ejection fraction (EF), ventricular systolic and diastolic function parameters, incremental test, and three questionnaires (Mediterranean Diet Adherence Screener, MEDAS; Oral Health Impact Profile, OHIP-14; Patient Health Questionnaire, PHQ)...
March 18, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535062/the-role-of-sars-cov-2-nucleocapsidic-antigen-and-krebs-von-den-lungen-6-serum-levels-in-predicting-covid-19-pneumonia-outcome
#6
JOURNAL ARTICLE
Stefano Sanduzzi Zamparelli, Vincenzo Fucci, Gaetano Rea, Francesco Perna, Marialuisa Bocchino, Alessandro Sanduzzi Zamparelli
BACKGROUND: The COVID-19 pandemic caused by SARS-CoV-2 continues to pose a significant threat worldwide, with severe cases leading to hospitalization and death. This study aims to evaluate the potential use of serum nucleocapsid antigen (NAg) and Krebs von den Lungen-6 glycoprotein (KL-6) as biomarkers of severe COVID-19 and to investigate their correlation with clinical, radiological, and biochemical parameters. METHODS: This retrospective study included 128 patients with confirmed SARS-CoV-2 infection admitted to a Neapolitan hospital in Italy between October 2020 and July 2021...
March 18, 2024: Diagnostics
https://read.qxmd.com/read/38535009/cardiac-magnetic-resonance-imaging-based-ischemic-injury-pattern-in-patients-with-acute-myocardial-infarction-sensu-left-ventricular-global-systolic-function
#7
JOURNAL ARTICLE
Lyudmila Salyamova, Valentin Oleynikov, Natalia Donetskaya, Alexander Vdovkin, Angelina Chernova, Irina Avdeeva
The purpose of the study was to identify factors characterizing a decrease in LV global systolic function in patients with ST-segment elevation myocardial infarction (STEMI) after revascularization using cardiac magnetic resonance imaging (MRI)-based ischemic injury pattern and laboratory parameters sensu left ventricular global systolic function. A total of 109 STEMI patients were examined. The patients underwent contrast-enhanced cardiac MRI with a 1.5 Tesla GE SIGNA Voyager (GE HealthCare, Chicago, IL, USA) on the 7th-10th days from the onset of the disease...
March 11, 2024: Diagnostics
https://read.qxmd.com/read/38534979/serum-pro-inflammatory-cytokines-and-leptin-as-potential-biomarkers-for-treatment-response-and-toxicity-in-locally-advanced-squamous-cell-carcinoma-of-the-head-and-neck
#8
JOURNAL ARTICLE
Amani A Alrehaili, Amal F Gharib, Maha M Bakhuraysah, Afaf Alharthi, Ohud Alsalmi, Fouzeyyah Ali Alsaeedi, Reem Ali Alhakami, Kamilah Ali Alasmari, Nuha Mohammed, Wael H Elsawy
Squamous cell carcinoma of the head and neck (HNSCC) is a globally prevalent form of cancer with significant morbidity and mortality rates. The present study examines the relationship of serum pro-inflammatory cytokines and leptin levels with the effectiveness of therapy in individuals with HNSCC and their potential role as biomarkers for treatment response and toxicity. Induction chemotherapy and concomitant chemoradiotherapy were evaluated for efficacy and safety in 52 individuals with HNSCC. Both response and toxicity were evaluated, and serum levels of pro-inflammatory cytokines Interlukin-1 beta (IL-1β), Interlukin-2 (IL-2), Interlukin-6 (IL-6), and Tumor Necrosis Factor-Alpha (TNF-α) and leptin were measured using enzyme-linked immunoassay before and after treatment...
March 11, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534974/protective-effects-of-propolis-and-chitosan-nanoparticles-against-ibuprofen-induced-hepatotoxicity-in-albino-rats
#9
JOURNAL ARTICLE
Fajer M AlKandari, Hussein S Mohamed, Sayed A Ahmed, Basant Mahmoud, Asmaa M Mahmoud
Post-marketing hepatotoxicity findings are more common or occur much later. NSAIDs (non-steroidal anti-inflammatory drugs) like ibuprofen are consumed in large quantities around the world. NSAIDs have a low incidence of hepatotoxicity but their wide use makes them a major contributor to drug-induced liver injury. Hepatitis is linked to systemic oxidative stress which results in cellular necrosis and fibrosis, as well as tissue lipoprotein peroxidation and glutathione depletion. Given the lack of safe and effective anti-hepatitis drugs in medicine today, natural substances appear to be a promising and safe alternative...
February 29, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534756/inflammation-factors-and-genistein-supplementation-in-cancer-preliminary-research
#10
JOURNAL ARTICLE
Karolina Banyś, Małgorzata Jelińska, Małgorzata Wrzosek, Dorota Skrajnowska, Robert Wrzesień, Wojciech Bielecki, Barbara Bobrowska-Korczak
The purpose of this study was to evaluate the effect of genistein in nano, micro, and macro forms on the intensity of the DMBA-induced tumor process in rats and to understand the mechanisms of this action. The effect of genistein supplementation on the content of selected eicosanoids (HETEs, HODE, and HEPE) in the serum of rats was evaluated. The levels and expression of genes encoding various pro-inflammatory cytokines (IL-1, IL-6) and MMP-9 in the blood of rats were also investigated. The biological material for the study was blood obtained from female rats of the Sprague Dawley strain (n = 32)...
March 7, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534744/an-examination-of-the-effects-of-propolis-and-quercetin-in-a-rat-model-of-streptozotocin-induced-diabetic-peripheral-neuropathy
#11
JOURNAL ARTICLE
Sibel Türedi, Hakim Çelik, Şeyda Nur Dağlı, Seyhan Taşkın, Uğur Şeker, Mustafa Deniz
The purpose of this study was to reveal the combined effects of propolis (P) and quercetin (Q) against diabetic peripheral neuropathy developing with streptozotocin-induced diabetes in rats. Sixty-four adult male rats were divided into eight equal groups: control, P (100 mg/kg/day), Q (100 mg/kg/day), P + Q (100 mg/day for both), diabetes mellitus (DM) (single-dose 60 mg/kg streptozotocin), DM + P, DM + Q, and DM + P + Q. The rats were sacrificed, and blood and sciatic nerve tissues were collected. Blood glucose and malondialdehyde (MDA) levels increased, while IL-6 and total antioxidant status decreased in the DM group ( p = 0...
March 2, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534738/effects-of-blood-derived-products-on-cellular-senescence-and-inflammatory-response-a-study-on-skin-rejuvenation
#12
JOURNAL ARTICLE
Harald Kühnel, Markus Pasztorek, Olga Kuten-Pella, Karina Kramer, Christoph Bauer, Zsombor Lacza, Stefan Nehrer
Blood-derived products, such as citrate platelet-rich plasma (CPRP) and hyperacute serum (HAS), are recognized for their rich growth factor content. When human dermal fibroblast (HDF) cells are exposed to combined mitogenic and DNA-damaging stimuli, it can lead to an increased burden of senescent cells and a modified senescence-associated secretory phenotype. In this study, the senescent state was comprehensively assessed through various methods, including phosphorylated histone H2AX (γH2AX) staining, p21 and p16 q-PCR, p21-western blot, growth curves, and senescence-associated ß-galactosidase staining...
February 28, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534731/dual-immunoglobulin-domain-containing-cell-adhesion-molecule-increases-early-in-renal-tubular-cell-injury-and-plays-anti-inflammatory-role
#13
JOURNAL ARTICLE
Jin Han, Ju-Min Yook, Se-Hyun Oh, Yu Kyung Chung, Hee-Yeon Jung, Ji-Young Choi, Jang-Hee Cho, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim, Seungwoo Han, Jeong-Hoon Lim
Dual immunoglobulin domain-containing cell adhesion molecule (DICAM) is a type I transmembrane protein that presents in various cells including renal tubular cells. This study evaluated the expression and protective role of DICAM in renal tubular cell injury. HK-2 cells were incubated and treated with lipopolysaccharide (LPS, 30 μg/mL) or hydrogen peroxide (H2 O2 , 100 μM) for 24 h. To investigate the effect of the gene silencing of DICAM, small interfering RNA of DICAM was used. Additionally, to explain its role in cellular response to injury, DICAM was overexpressed using an adenoviral vector...
February 26, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534376/effects-of-diabetes-mellitus-on-corneal-immune-cell-activation-and-the-development-of-keratopathy
#14
JOURNAL ARTICLE
Pier Luigi Surico, Akitomo Narimatsu, Katayoon Forouzanfar, Rohan Bir Singh, Sara Shoushtari, Reza Dana, Tomas Blanco
Diabetes mellitus (DM) is one of the most prevalent diseases globally, and its prevalence is rapidly increasing. Most patients with a long-term history of DM present with some degree of keratopathy (DK). Despite its high incidence, the underlying inflammatory mechanism of DK has not been elucidated yet. For further insights into the underlying immunopathologic processes, we utilized streptozotocin-induced mice to model type 1 DM (T1D) and B6.Cg-Lepob/J mice to model type 2 DM (T2D). We evaluated the animals for the development of clinical manifestations of DK...
March 18, 2024: Cells
https://read.qxmd.com/read/38533894/long-term-intake-of-thermo-induced-oxidized-oil-results-in-anxiety-like-and-depression-like-behaviors-involvement-of-microglia-and-astrocytes
#15
JOURNAL ARTICLE
Meishan Lu, Jiachen Shi, Xue Li, Yanjun Liu, Yuanfa Liu
Frequent consumption of fried foods has been strongly associated with a higher risk of anxiety and depression, particularly among young individuals. The existing evidence has indicated that acrylamide produced from starchy foods at high temperatures can induce anxious behavior. However, there is limited research on the nerve damage caused by thermo-induced oxidized oil (TIOO). In this study, we conducted behavioral tests on mice and found that prolonged consumption of TIOO led to significant anxiety behavior and a tendency toward depression...
March 27, 2024: Food & Function
https://read.qxmd.com/read/38533322/immunological-risk-factors-in-recurrent-pregnancy-loss-in-patients-with-hereditary-thrombophilia
#16
JOURNAL ARTICLE
Zlatko Kirovakov, Emiliana Konova, Nadezhda Hinkova, Stefani Markova, Plamen Penchev
BACKGROUND: Recurrent pregnancy loss (RPL) is a complicated reproductive disorder with underlying genetic and immunological causes. RPL may be influenced by hereditary thrombophilia, a class of blood clotting-related genetic abnormalities, via the vascular and immune systems. This study examines the immunological characteristics that hereditary thrombophilia patients have in common with RPL. METHODS: A prospective cohort study included 300 patients split into two groups: a control group without hereditary thrombophilia and a group with the condition...
March 2024: Curēus
https://read.qxmd.com/read/38533139/unraveling-proto-oncogene-erbb2-expression-in-patients-with-carcinoma-head-of-pancreas-and-chronic-pancreatitis-patients-a-case-control-study
#17
JOURNAL ARTICLE
Abhina Mohanan, Pottakkat Biju, Balasubramaniyan V, Gladwin V
Background The pre-malignant tendency of the normal, non-affected portion of the pancreas is not as well explored as the multicentricity documented in pancreatic cancer cases. In order to ascertain the expression of inflammatory markers and Erythroblastic Oncogene B ( ErbB2 ) in the non-affected pancreas in patients with pancreatic cancer, a case-control study was carried out. Materials and methods In patients who underwent pancreatoduodenectomy for pancreatic cancer (PC), pro-inflammatory genes and a tumor marker, erythroblastic oncogene 2 ( ErbB2 ) in the epidermal growth factor receptor family were analyzed in the pancreatic tissue at the cut surface of the normal pancreas using qRT-PCR...
February 2024: Curēus
https://read.qxmd.com/read/38533073/role-of-the-cxcr-4-gn%C3%AE-q-plc%C3%AE-signaling-pathway-in-the-pathogenesis-of-collagen-induced-arthritis-in-rats
#18
JOURNAL ARTICLE
Zhen Li, Jingshu Liu, Xiaowei Sun, Yutong Li
Rheumatoid arthritis (RA) is a chronic autoimmune disease in which immune cells and inflammatory cytokines are abnormally activated, leading to immunoregulatory dysfunction in the body and triggering systemic inflammatory responses. The interaction between CXC chemokine receptor 4 (CXCR4) and heterotrimeric G-protein α-subunit Gαq (Gnαq) activates phospholipase Cβ (PLCβ), which influences the expression of downstream effectors and participates widely in the onset and development of various diseases, thus suggesting the potential involvement of these molecules in RA pathogenesis...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533053/il-22-promotes-liver-regeneration-after-portal-vein-ligation
#19
JOURNAL ARTICLE
Tao Zhang, Philipp Seeger, Yashin Simsek, Morsal Sabihi, Jöran Lücke, Dimitra E Zazara, Ahmad Mustafa Shiri, Jan Kempski, Tom Blankenburg, Lilan Zhao, Ioannis Belios, Andres Machicote, Baris Mercanoglu, Mohammad Fard-Aghaie, Sara Notz, Panagis M Lykoudis, Marius Kemper, Tarik Ghadban, Oliver Mann, Thilo Hackert, Jakob R Izbicki, Thomas Renné, Samuel Huber, Anastasios D Giannou, Jun Li
BACKGROUND: Insufficient remnant liver volume (RLV) after the resection of hepatic malignancy could lead to liver failure and mortality. Portal vein ligation (PVL) prior to hepatectomy is subsequently introduced to increase the remnant liver volume and improve the outcome of hepatic malignancy. IL-22 has previously been reported to promote liver regeneration, while facilitating tumor development in the liver via Steap4 upregulation. Here we performed PVL in mouse models to study the role of IL-22 in liver regeneration post-PVL...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38533037/dexmedetomidine-suppressed-the-biological-behavior-of-raw264-7-cells-treated-with-lps-by-down-regulating-hotair
#20
JOURNAL ARTICLE
Qin Liu, Guang-Hu Yang, Nai-Zhi Wang, Xin-Cheng Wang, Zhao-Long Zhang, Lu-Jun Qiao, Wen-Juan Cui
BACKGROUND: Previous studies have revealed dexmedetomidine have potential protective effects on vital organs by inhibiting the release of inflammatory cytokines. To investigate the effects of dexmedetomidine on sepsis, especially in the initial inflammatory stage of sepsis. RAW264.7 cells were used as the cell model in this study to elucidate the underlying mechanisms. METHODS: In this study, we conducted several assays to investigate the mechanisms of dexmedetomidine and HOTAIR in sepsis...
March 30, 2024: Heliyon
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