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https://www.readbyqxmd.com/read/28325101/-i-had-no-idea-what-a-complicated-business-eating-is%C3%A2-a-qualitative-study-of-the-impact-of-dysphagia-during-stroke-recovery
#1
Jennifer Moloney, Margaret Walshe
AIM: Persons with dysphagia following stroke may experience uncomfortable symptoms such as persistent coughing, choking and poor salivary management. They may also spend long periods of time unable to eat or drink or with restrictions on oral intake. Experiences of dysphagia post-stroke are richly described in unsolicited narratives such as autobiographies on the stroke event, which often include details of the author's journey through their stroke recovery. The aim of this study is to use autobiographical accounts to explore the experiences of those living with dysphagia following stroke...
March 21, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28196539/does-access-to-a-demand-led-evidence-briefing-service-improve-uptake-and-use-of-research-evidence-by-health-service-commissioners-a-controlled-before-and-after-study
#2
Paul M Wilson, Kate Farley, Liz Bickerdike, Alison Booth, Duncan Chambers, Mark Lambert, Carl Thompson, Rhiannon Turner, Ian S Watt
BACKGROUND: The Health and Social Care Act mandated research use as a core consideration of health service commissioning arrangements in England. We undertook a controlled before and after study to evaluate whether access to a demand-led evidence briefing service improved the use of research evidence by commissioners compared with less intensive and less targeted alternatives. METHODS: Nine Clinical Commissioning Groups (CCGs) in the North of England received one of three interventions: (A) access to an evidence briefing service; (B) contact plus an unsolicited push of non-tailored evidence; or (C) unsolicited push of non-tailored evidence...
February 14, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/27935147/cycles-of-silence-first-nations-women-overcoming-social-and-historical-barriers-in-supportive-cancer-care
#3
Chad Hammond, Roanne Thomas, Wendy Gifford, Jennifer Poudrier, Ryan Hamilton, Carolyn Brooks, Tricia Morrison, Tracy Scott, Doris Warner
BACKGROUND: First Nations people with cancer in Canada confront several critical inequities in physical and psychosocial domains. First Nations women are at a particular disadvantage as they are disproportionately affected by social determinants of health, but how they navigate these challenges within their communities is poorly understood. OBJECTIVE: Our study explores survivorship experiences of First Nations women with cancer and their caregivers. Drawing from a larger data set on survivorship, we identify several major barriers to cancer communication and support in First Nations communities...
December 9, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27846607/neural-correlates-of-ticklishness-in-the-rat-somatosensory-cortex
#4
S Ishiyama, M Brecht
Rats emit ultrasonic vocalizations in response to tickling by humans. Tickling is rewarding through dopaminergic mechanisms, but the function and neural correlates of ticklishness are unknown. We confirmed that tickling of rats evoked vocalizations, approach, and unsolicited jumps (Freudensprünge). Recordings in the trunk region of the rat somatosensory cortex showed intense tickling-evoked activity in most neurons, whereas a minority of cells were suppressed by tickling. Tickling responses predicted nontactile neural responses to play behaviors, which suggests a neuronal link between tickling and play...
November 11, 2016: Science
https://www.readbyqxmd.com/read/27826478/evaluation-of-migraine-surgery-outcomes-through-social-media
#5
Katie G Egan, Jacqueline S Israel, Rezvaneh Ghasemzadeh, Ahmed M Afifi
BACKGROUND: Social media have been used to study many aspects of health and human behavior. Although social media present a unique opportunity to obtain unsolicited patient-reported outcomes, its use has been limited in plastic and reconstructive surgical procedures, including migraine nerve surgery. The goal of this study was to utilize the most popular social media site, Facebook, to evaluate patients' experience with migraine surgery. METHODS: Six months of data regarding nerve surgery, nerve stimulators, and radiofrequency nerve ablation were collected from posts and comments written by members of 2 Facebook groups...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27740563/a-matter-of-life-and-death-end-of-life-simulation-to-develop-confidence-in-nursing-students
#6
Charys Kunkel, Wendy Kopp, Melissa Hanson
The use of simulation to provide end-of-life (EOL) education is a means to enhance self-efficacy levels among nursing students. The purpose of this exploratory study was to evaluate self-efficacy levels of nursing students and recent graduate nurses following an EOL simulation experience. Data were obtained using the Simulation Effectiveness Tool developed by Medical Education Technologies, Inc.; 72 participants in three groups completed the study. Moderate to strong levels of confidence in providing EOL care were found following the simulation experience; observations by the researcher and unsolicited participant statements supported the findings...
September 2016: Nursing Education Perspectives
https://www.readbyqxmd.com/read/27647774/am-i-my-family-s-keeper-disclosure-dilemmas-in-next-generation-sequencing
#7
Roel H P Wouters, Rhodé M Bijlsma, Margreet G E M Ausems, Johannes J M van Delden, Emile E Voest, Annelien L Bredenoord
Ever since genetic testing is possible for specific mutations, ethical debate has sparked on the question of whether professionals have a duty to warn not only patients but also their relatives that might be at risk for hereditary diseases. As next-generation sequencing (NGS) swiftly finds its way into clinical practice, the question who is responsible for conveying unsolicited findings to family members becomes increasingly urgent. Traditionally, there is a strong emphasis on the duties of the professional in this debate...
December 2016: Human Mutation
https://www.readbyqxmd.com/read/27551783/users-polarization-on-facebook-and-youtube
#8
Alessandro Bessi, Fabiana Zollo, Michela Del Vicario, Michelangelo Puliga, Antonio Scala, Guido Caldarelli, Brian Uzzi, Walter Quattrociocchi
Users online tend to select information that support and adhere their beliefs, and to form polarized groups sharing the same view-e.g. echo chambers. Algorithms for content promotion may favour this phenomenon, by accounting for users preferences and thus limiting the exposure to unsolicited contents. To shade light on this question, we perform a comparative study on how same contents (videos) are consumed on different online social media-i.e. Facebook and YouTube-over a sample of 12M of users. Our findings show that content drives the emergence of echo chambers on both platforms...
2016: PloS One
https://www.readbyqxmd.com/read/27473200/diverse-and-dynamic-interactions-a-model-of-suicidal-men-s-help-seeking-as-it-relates-to-health-services
#9
Jo River
There is a striking gender difference in suicide rates worldwide, with men accounting for approximately 80% of all suicide deaths. In contradictory public discussions, suicidal men are presented sometimes as victims of "poor" health services and sometimes as irremediable, "poor" help seekers. A more substantive theory of suicidal men's help seeking, which moves beyond homogenizing accounts to examine the complex interplay between help seeking and health services, is now required. Eighteen life history interviews were undertaken with men who had engaged in nonfatal suicide...
July 29, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27460421/whole-exome-sequencing-in-pediatrics-parents-considerations-toward-return-of-unsolicited-findings-for-their-child
#10
Candice Cornelis, Aad Tibben, Wybo Dondorp, Mieke van Haelst, Annelien L Bredenoord, Nine Knoers, Marcus Düwell, Ineke Bolt, Marieke van Summeren
Parents' preferences for unsolicited findings (UFs) from diagnostic whole-exome sequencing (WES) for their children remain largely unexplored. Our aim was to gain insight into parental considerations favoring acceptance/decline of UFs pertaining to their child. We conducted 20 qualitative, semistructured interviews with parents (n=34) of children with a developmental delay, aged <1 to 17 years, after consenting to WES, but before feedback of results. Key findings from our study were that all parents favored acceptance of UFs for medically actionable conditions in childhood, but that preferences and considerations diverged for UFs with no medical actionability, or only in adulthood, and regarding carrier-status...
December 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27449518/rdna-copy-number-variants-are-frequent-passenger-mutations-in-saccharomyces-cerevisiae-deletion-collections-and-de-novo-transformants
#11
Elizabeth X Kwan, Xiaobin S Wang, Haley M Amemiya, Bonita J Brewer, M K Raghuraman
The Saccharomyces cerevisiae ribosomal DNA (rDNA) locus is known to exhibit greater instability relative to the rest of the genome. However, wild-type cells preferentially maintain a stable number of rDNA copies, suggesting underlying genetic control of the size of this locus. We performed a screen of a subset of the Yeast Knock-Out (YKO) single gene deletion collection to identify genetic regulators of this locus and to determine if rDNA copy number correlates with yeast replicative lifespan. While we found no correlation between replicative lifespan and rDNA size, we identified 64 candidate strains with significant rDNA copy number differences...
September 8, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27421049/-it-is-better-to-die-experiences-of-traditional-health-practitioners-within-the-hiv-treatment-as-prevention-trial-communities-in-rural-south-africa-anrs-12249-tasp-trial
#12
Mosa Moshabela, Thembelihle Zuma, Joanna Orne-Gliemann, Collins Iwuji, Joseph Larmarange, Nuala McGrath
The ANRS 12249 Treatment-as-Prevention (TasP) cluster-randomized trial in rural South Africa uses a "test and treat" approach. Home-based testing services and antiretroviral treatment initiation satellite clinics were implemented in every cluster as part of the trial. A social science research agenda was nested within TasP with the aim of understanding the social, economic and contextual factors that affect individuals, households, communities and health systems with respect to TasP. Considering the rural nature of the trial setting, we sought to understand community perceptions and experiences of the TasP Trial interventions as seen through the eyes of traditional health practitioners (THPs)...
2016: AIDS Care
https://www.readbyqxmd.com/read/27337116/-recruiting-and-personal-development-in-surgical-departments-of-large-referral-centers-current-practice-and-options-for-improvement-from-industry-and-service-business
#13
K Homayounfar, S König, C Rabe, B Beck-Broichsitter, U Lützen, M B Ghadimi, C Schmidt
Background: Cut-throat competition, cost pressure, generation Y, shortage of qualified staff and feminisation influence human resources management in visceral surgery. The assessment of the current situation by chief surgeons (CS) as well as proof of transferability of strategies from industry and service business (ISB) have not yet been investigated. Material and Methods: The CS of university hospitals and large referral centres (> 800 beds) were interviewed (n = 100) on the basis of a standardised questionnaire including 43 items...
June 23, 2016: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/27117661/maternal-plasma-dna-and-rna-sequencing-for-prenatal-testing
#14
REVIEW
Saskia Tamminga, Merel van Maarle, Lidewij Henneman, Cees B M Oudejans, Martina C Cornel, Erik A Sistermans
Cell-free DNA (cfDNA) testing has recently become indispensable in diagnostic testing and screening. In the prenatal setting, this type of testing is often called noninvasive prenatal testing (NIPT). With a number of techniques, using either next-generation sequencing or single nucleotide polymorphism-based approaches, fetal cfDNA in maternal plasma can be analyzed to screen for rhesus D genotype, common chromosomal aneuploidies, and increasingly for testing other conditions, including monogenic disorders. With regard to screening for common aneuploidies, challenges arise when implementing NIPT in current prenatal settings...
2016: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/27071717/unsolicited-findings-of-next-generation-sequencing-for-tumor-analysis-within-a-dutch-consortium-clinical-daily-practice-reconsidered
#15
Rhodé M Bijlsma, Annelien L Bredenoord, Christa G Gadellaa-Hooijdonk, Martijn Pj Lolkema, Stefan Sleijfer, Emile E Voest, Margreet Gem Ausems, Neeltje Steeghs
Cancer patients participating in studies involving experimental or diagnostic next-generation sequencing (NGS) procedures are confronted with the possibility of unsolicited findings. The Center for Personalized Cancer Treatment (CPCT), a Dutch consortium of cancer centers, is offering centralized large-scale NGS for the discovery of somatic tumor mutations with their germline DNA as reference. The CPCT aims to give all cancer patients with advanced disease stages access to tumor DNA analysis in order to improve selection for experimental therapy...
October 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/26611190/dimensions-discourses-and-differences-trainees-conceptualising-health-care-leadership-and-followership
#16
Lisi J Gordon, Charlotte E Rees, Jean S Ker, Jennifer Cleland
CONTEXT: As doctors in all specialties are expected to undertake leadership within health care organisations, leadership development has become an inherent part of medical education. Whereas the leadership literature within medical education remains mostly focused on individual, hierarchical leadership, contemporary theory posits leadership as a group process, which should be distributed across all levels of health care organisation. This gap between theory and practice indicates that there is a need to understand what leadership and followership mean to medical trainees working in today's interprofessional health care workplace...
December 2015: Medical Education
https://www.readbyqxmd.com/read/26335083/summary-of-findings-from-the-fda-regulatory-science-forum-on-measuring-sexual-dysfunction-in-depression-trials
#17
REVIEW
Phillip D Kronstein, Eiji Ishida, Ni A Khin, Eric Chang, H M James Hung, Robert J Temple, Peiling Yang
OBJECTIVE: Sexual dysfunction is a significant treatment-emergent adverse reaction to the serotonergic antidepressants (selective serotonin reuptake inhibitors [SSRIs] and serotonin-norepinephrine reuptake inhibitors [SNRIs]). However, the rate of sexual dysfunction is often underestimated in registration trials, which have relied on unsolicited reports. We conducted a literature search to examine the rates of sexual dysfunction with SSRIs/SNRIs when these rates were ascertained by structured questionnaires or standardized instruments...
August 2015: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/26291877/climate-change-sentiment-on-twitter-an-unsolicited-public-opinion-poll
#18
Emily M Cody, Andrew J Reagan, Lewis Mitchell, Peter Sheridan Dodds, Christopher M Danforth
The consequences of anthropogenic climate change are extensively debated through scientific papers, newspaper articles, and blogs. Newspaper articles may lack accuracy, while the severity of findings in scientific papers may be too opaque for the public to understand. Social media, however, is a forum where individuals of diverse backgrounds can share their thoughts and opinions. As consumption shifts from old media to new, Twitter has become a valuable resource for analyzing current events and headline news...
2015: PloS One
https://www.readbyqxmd.com/read/26258007/spontaneous-entrainment-of-running-cadence-to-music-tempo
#19
Edith Van Dyck, Bart Moens, Jeska Buhmann, Michiel Demey, Esther Coorevits, Simone Dalla Bella, Marc Leman
BACKGROUND: Since accumulating evidence suggests that step rate is strongly associated with running-related injuries, it is important for runners to exercise at an appropriate running cadence. As music tempo has been shown to be capable of impacting exercise performance of repetitive endurance activities, it might also serve as a means to (re)shape running cadence. The aim of this study was to validate the impact of music tempo on running cadence. METHODS: Sixteen recreational runners ran four laps of 200 m (i...
2015: Sports Medicine—Open
https://www.readbyqxmd.com/read/25920556/attitudes-of-nearly-7000-health-professionals-genomic-researchers-and-publics-toward-the-return-of-incidental-results-from-sequencing-research
#20
Anna Middleton, Katherine I Morley, Eugene Bragin, Helen V Firth, Matthew E Hurles, Caroline F Wright, Michael Parker
Genome-wide sequencing in a research setting has the potential to reveal health-related information of personal or clinical utility for the study participant. There is increasing pressure to return research findings to participants that may not be related to the project aims, particularly when these could be used to prevent disease. Such secondary, unsolicited or 'incidental findings' (IFs) may be discovered unintentionally when interpreting sequence data, or as the result of a deliberate opportunistic screen...
January 2016: European Journal of Human Genetics: EJHG
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