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https://www.readbyqxmd.com/read/29045504/molecular-tumor-boards-current-practice-and-future-needs
#1
D L van der Velden, C M L van Herpen, H W M van Laarhoven, E F Smit, H J M Groen, S M Willems, P M Nederlof, M H G Langenberg, E Cuppen, S Sleijfer, N Steeghs, E E Voest
Background: due to rapid technical advances, steeply declining sequencing costs, and the ever-increasing number of targeted therapies, it can be expected that extensive tumor sequencing such as Whole Exome- and -Genome Sequencing will soon be applied in standard care. Clinicians will thus be confronted with increasingly complex genetic information and multiple test-platforms to choose from. General medical training, meanwhile, can hardly keep up with the pace of innovation. Consequently, there is a rapidly growing gap between clinical knowledge and genetic potential in cancer care...
September 27, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28982488/twenty-first-century-precision-medicine-in-oncology-genomic-profiling-in-patients-with-cancer
#2
REVIEW
Mitesh J Borad, Patricia M LoRusso
The advent of next-generation sequencing has accelerated the implementation of genomic profiling in the care and management of patients with cancer. Initial efforts have focused on target identification in patients with advanced cancer. Prognostication, resistance detection, disease monitoring, and early detection efforts are also underway. This review highlights some of the challenges in this evolving space. This includes choosing between gene-panel and comprehensive approaches, DNA and transcriptome data integration, reduction of false-positive variants, addressing tumor heterogeneity, establishment of workflows to address unsolicited findings, and data sharing and privacy concerns...
October 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28975656/scanning-the-body-sequencing-the-genome-dealing-with-unsolicited-findings
#3
Roel H P Wouters, Candice Cornelis, Ainsley J Newson, Eline M Bunnik, Annelien L Bredenoord
The introduction of novel diagnostic techniques in clinical domains such as genomics and radiology has led to a rich ethical debate on how to handle unsolicited findings that result from these innovations. Yet while unsolicited findings arise in both genomics and radiology, most of the relevant literature to date has tended to focus on only one of these domains. In this article, we synthesize and critically assess similarities and differences between "scanning the body" and "sequencing the genome" from an ethical perspective...
November 2017: Bioethics
https://www.readbyqxmd.com/read/28852913/cancer-patients-intentions-towards-receiving-unsolicited-genetic-information-obtained-using-next-generation-sequencing
#4
Rhodé M Bijlsma, Hester Wessels, Roel H P Wouters, Anne M May, Margreet G E M Ausems, Emile E Voest, Annelien L Bredenoord
Next-generation sequencing (NGS) can be used to generate information about a patient's tumour and personal genome. This powerful diagnostic tool provides solicited and unsolicited hereditary genetic (risk) information that could have consequences for cancer patients and their quality of life. A well-defined approach for returning appropriate genetic risk information is needed in personalized cancer care. A qualitative design with semi-structured interviews was used. We conducted interviews with 24 Dutch patients with different types of cancer, both NGS-experienced and NGS-inexperienced, to learn their intentions, needs and preferences towards receiving unsolicited genetic information obtained using NGS...
August 29, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28800502/spotlight-on-equality-of-employment-opportunities-a-qualitative-study-of-job-seeking-experiences-of-graduating-nurses-and-physiotherapists-from-black-and-minority-ethnic-backgrounds
#5
John Hammond, Sylvie Marshall-Lucette, Nigel Davies, Fiona Ross, Ruth Harris
BACKGROUND: There is growing attention in the UK and internationally to the representation of black and minority ethnic groups in healthcare education and the workplace. Although the NHS workforce is very diverse, ethnic minorities are unevenly spread across occupations, and considerably underrepresented in senior positions. Previous research has highlighted that this inequality also exists at junior levels with newly qualified nurses from non-White/British ethnic groups being less likely to get a job at graduation than their White/British colleagues...
August 1, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28796578/sharing-sex-secrets-on-facebook-a-content-analysis-of-youth-peer-communication-and-advice-exchange-on-social-media-about-sexual-health-and-intimate-relations
#6
Tien Ee Dominic Yeo, Tsz Hang Chu
Social media present opportunities and challenges for sexual health communication among young people. This study is one of the first to examine the actual use of Facebook for peer communication of sexual health and intimate relations. Content analysis of 2186 anonymous posts in a "sex secrets" Facebook page unofficially affiliated with a Hong Kong University shows gender balance among posters, inclusiveness of sexual minorities, and frequent sharing of personal experiences in storytelling or advice seeking...
September 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28512758/reporting-practices-for-unsolicited-and-secondary-findings-from-next-generation-sequencing-technologies-perspectives-of-laboratory-personnel
#7
Danya F Vears, Karine Sénécal, Pascal Borry
While next-generation sequencing (NGS) has enormous potential to identify genetic causes of disease, the nature of the technology means that it can also identify additional information about the individual receiving sequencing that is unrelated to the original rationale for testing. Reporting these unsolicited findings (UF) to clinicians, and subsequently to patients, could lead to potentially lifesaving interventions. Most international guidelines provide limited specific recommendations as to whether these UF should be reported...
August 2017: Human Mutation
https://www.readbyqxmd.com/read/28365225/safety-and-immunogenicity-of-one-versus-two-doses-of-takeda-s-tetravalent-dengue-vaccine-in-children-in-asia-and-latin-america-interim-results-from-a-phase-2-randomised-placebo-controlled-study
#8
RANDOMIZED CONTROLLED TRIAL
Xavier Sáez-Llorens, Vianney Tricou, Delia Yu, Luis Rivera, Suely Tuboi, Pedro Garbes, Astrid Borkowski, Derek Wallace
BACKGROUND: Dengue is the most common mosquito-borne viral disease in human beings, and vector control has not halted its spread worldwide. A dengue vaccine for individuals aged 9 years and older has been licensed, but there remains urgent medical need for a vaccine that is safe and effective against all four dengue virus serotypes (DENV-1-4) in recipients of all ages. Here, we present the preplanned interim analyses at 6 months of a tetravalent dengue vaccine candidate (TDV), which is comprised of an attenuated DENV-2 virus strain (TDV-2) and three chimeric viruses containing the premembrane and envelope protein genes of DENV-1, DENV-3, and DENV-4 genetically engineered into the attenuated TDV-2 genome backbone (TDV-1, TDV-3, and TDV-4)...
June 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28325101/-i-had-no-idea-what-a-complicated-business-eating-is%C3%A2-a-qualitative-study-of-the-impact-of-dysphagia-during-stroke-recovery
#9
Jennifer Moloney, Margaret Walshe
AIM: Persons with dysphagia following stroke may experience uncomfortable symptoms such as persistent coughing, choking and poor salivary management. They may also spend long periods of time unable to eat or drink or with restrictions on oral intake. Experiences of dysphagia post-stroke are richly described in unsolicited narratives such as autobiographies on the stroke event, which often include details of the author's journey through their stroke recovery. The aim of this study is to use autobiographical accounts to explore the experiences of those living with dysphagia following stroke...
March 21, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28196539/does-access-to-a-demand-led-evidence-briefing-service-improve-uptake-and-use-of-research-evidence-by-health-service-commissioners-a-controlled-before-and-after-study
#10
Paul M Wilson, Kate Farley, Liz Bickerdike, Alison Booth, Duncan Chambers, Mark Lambert, Carl Thompson, Rhiannon Turner, Ian S Watt
BACKGROUND: The Health and Social Care Act mandated research use as a core consideration of health service commissioning arrangements in England. We undertook a controlled before and after study to evaluate whether access to a demand-led evidence briefing service improved the use of research evidence by commissioners compared with less intensive and less targeted alternatives. METHODS: Nine Clinical Commissioning Groups (CCGs) in the North of England received one of three interventions: (A) access to an evidence briefing service; (B) contact plus an unsolicited push of non-tailored evidence; or (C) unsolicited push of non-tailored evidence...
February 14, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/27935147/cycles-of-silence-first-nations-women-overcoming-social-and-historical-barriers-in-supportive-cancer-care
#11
Chad Hammond, Roanne Thomas, Wendy Gifford, Jennifer Poudrier, Ryan Hamilton, Carolyn Brooks, Tricia Morrison, Tracy Scott, Doris Warner
BACKGROUND: First Nations people with cancer in Canada confront several critical inequities in physical and psychosocial domains. First Nations women are at a particular disadvantage as they are disproportionately affected by social determinants of health, but how they navigate these challenges within their communities is poorly understood. OBJECTIVE: Our study explores survivorship experiences of First Nations women with cancer and their caregivers. Drawing from a larger data set on survivorship, we identify several major barriers to cancer communication and support in First Nations communities...
December 9, 2016: Psycho-oncology
https://www.readbyqxmd.com/read/27846607/neural-correlates-of-ticklishness-in-the-rat-somatosensory-cortex
#12
S Ishiyama, M Brecht
Rats emit ultrasonic vocalizations in response to tickling by humans. Tickling is rewarding through dopaminergic mechanisms, but the function and neural correlates of ticklishness are unknown. We confirmed that tickling of rats evoked vocalizations, approach, and unsolicited jumps (Freudensprünge). Recordings in the trunk region of the rat somatosensory cortex showed intense tickling-evoked activity in most neurons, whereas a minority of cells were suppressed by tickling. Tickling responses predicted nontactile neural responses to play behaviors, which suggests a neuronal link between tickling and play...
November 11, 2016: Science
https://www.readbyqxmd.com/read/27826478/evaluation-of-migraine-surgery-outcomes-through-social-media
#13
Katie G Egan, Jacqueline S Israel, Rezvaneh Ghasemzadeh, Ahmed M Afifi
BACKGROUND: Social media have been used to study many aspects of health and human behavior. Although social media present a unique opportunity to obtain unsolicited patient-reported outcomes, its use has been limited in plastic and reconstructive surgical procedures, including migraine nerve surgery. The goal of this study was to utilize the most popular social media site, Facebook, to evaluate patients' experience with migraine surgery. METHODS: Six months of data regarding nerve surgery, nerve stimulators, and radiofrequency nerve ablation were collected from posts and comments written by members of 2 Facebook groups...
October 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27740563/a-matter-of-life-and-death-end-of-life-simulation-to-develop-confidence-in-nursing-students
#14
Charys Kunkel, Wendy Kopp, Melissa Hanson
The use of simulation to provide end-of-life (EOL) education is a means to enhance self-efficacy levels among nursing students. The purpose of this exploratory study was to evaluate self-efficacy levels of nursing students and recent graduate nurses following an EOL simulation experience. Data were obtained using the Simulation Effectiveness Tool developed by Medical Education Technologies, Inc.; 72 participants in three groups completed the study. Moderate to strong levels of confidence in providing EOL care were found following the simulation experience; observations by the researcher and unsolicited participant statements supported the findings...
September 2016: Nursing Education Perspectives
https://www.readbyqxmd.com/read/27647774/am-i-my-family-s-keeper-disclosure-dilemmas-in-next-generation-sequencing
#15
Roel H P Wouters, Rhodé M Bijlsma, Margreet G E M Ausems, Johannes J M van Delden, Emile E Voest, Annelien L Bredenoord
Ever since genetic testing is possible for specific mutations, ethical debate has sparked on the question of whether professionals have a duty to warn not only patients but also their relatives that might be at risk for hereditary diseases. As next-generation sequencing (NGS) swiftly finds its way into clinical practice, the question who is responsible for conveying unsolicited findings to family members becomes increasingly urgent. Traditionally, there is a strong emphasis on the duties of the professional in this debate...
December 2016: Human Mutation
https://www.readbyqxmd.com/read/27551783/users-polarization-on-facebook-and-youtube
#16
Alessandro Bessi, Fabiana Zollo, Michela Del Vicario, Michelangelo Puliga, Antonio Scala, Guido Caldarelli, Brian Uzzi, Walter Quattrociocchi
Users online tend to select information that support and adhere their beliefs, and to form polarized groups sharing the same view-e.g. echo chambers. Algorithms for content promotion may favour this phenomenon, by accounting for users preferences and thus limiting the exposure to unsolicited contents. To shade light on this question, we perform a comparative study on how same contents (videos) are consumed on different online social media-i.e. Facebook and YouTube-over a sample of 12M of users. Our findings show that content drives the emergence of echo chambers on both platforms...
2016: PloS One
https://www.readbyqxmd.com/read/27473200/diverse-and-dynamic-interactions-a-model-of-suicidal-men-s-help-seeking-as-it-relates-to-health-services
#17
Jo River
There is a striking gender difference in suicide rates worldwide, with men accounting for approximately 80% of all suicide deaths. In contradictory public discussions, suicidal men are presented sometimes as victims of "poor" health services and sometimes as irremediable, "poor" help seekers. A more substantive theory of suicidal men's help seeking, which moves beyond homogenizing accounts to examine the complex interplay between help seeking and health services, is now required. Eighteen life history interviews were undertaken with men who had engaged in nonfatal suicide...
July 29, 2016: American Journal of Men's Health
https://www.readbyqxmd.com/read/27460421/whole-exome-sequencing-in-pediatrics-parents-considerations-toward-return-of-unsolicited-findings-for-their-child
#18
Candice Cornelis, Aad Tibben, Wybo Dondorp, Mieke van Haelst, Annelien L Bredenoord, Nine Knoers, Marcus Düwell, Ineke Bolt, Marieke van Summeren
Parents' preferences for unsolicited findings (UFs) from diagnostic whole-exome sequencing (WES) for their children remain largely unexplored. Our aim was to gain insight into parental considerations favoring acceptance/decline of UFs pertaining to their child. We conducted 20 qualitative, semistructured interviews with parents (n=34) of children with a developmental delay, aged <1 to 17 years, after consenting to WES, but before feedback of results. Key findings from our study were that all parents favored acceptance of UFs for medically actionable conditions in childhood, but that preferences and considerations diverged for UFs with no medical actionability, or only in adulthood, and regarding carrier-status...
December 2016: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/27449518/rdna-copy-number-variants-are-frequent-passenger-mutations-in-saccharomyces-cerevisiae-deletion-collections-and-de-novo-transformants
#19
Elizabeth X Kwan, Xiaobin S Wang, Haley M Amemiya, Bonita J Brewer, M K Raghuraman
The Saccharomyces cerevisiae ribosomal DNA (rDNA) locus is known to exhibit greater instability relative to the rest of the genome. However, wild-type cells preferentially maintain a stable number of rDNA copies, suggesting underlying genetic control of the size of this locus. We performed a screen of a subset of the Yeast Knock-Out (YKO) single gene deletion collection to identify genetic regulators of this locus and to determine if rDNA copy number correlates with yeast replicative lifespan. While we found no correlation between replicative lifespan and rDNA size, we identified 64 candidate strains with significant rDNA copy number differences...
September 8, 2016: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/27421049/-it-is-better-to-die-experiences-of-traditional-health-practitioners-within-the-hiv-treatment-as-prevention-trial-communities-in-rural-south-africa-anrs-12249-tasp-trial
#20
Mosa Moshabela, Thembelihle Zuma, Joanna Orne-Gliemann, Collins Iwuji, Joseph Larmarange, Nuala McGrath
The ANRS 12249 Treatment-as-Prevention (TasP) cluster-randomized trial in rural South Africa uses a "test and treat" approach. Home-based testing services and antiretroviral treatment initiation satellite clinics were implemented in every cluster as part of the trial. A social science research agenda was nested within TasP with the aim of understanding the social, economic and contextual factors that affect individuals, households, communities and health systems with respect to TasP. Considering the rural nature of the trial setting, we sought to understand community perceptions and experiences of the TasP Trial interventions as seen through the eyes of traditional health practitioners (THPs)...
2016: AIDS Care
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