keyword
https://read.qxmd.com/read/34749849/sentinel-lymph-node-biopsy-in-breast-cancer-principle-difficulties-and-pitfalls
#21
JOURNAL ARTICLE
George Iancu, Laura M Mustata, Ruxandra Cigaran, Nicolae Gica, Radu Botezatu, Dragos Median, Anca Maria Panaitescu, Gheorghe Peltecu
Sentinel Lymph node biopsy (SLNB) represents the standard approach in a newly diagnosed breast cancer for axillary staging in cases of clinical node negative. This represents a major prognostic factor and the biopsy of sentinel lymph node for early breast cancer is used as guidance in surgical and oncological treatment. Although for many decades, axillary lymph node dissection was the standard approach for breast cancer treatment and staging, this pathway was abandoned due to significant risk of lymphedema, infection, nerve and vessels injury or dysfunction of the shoulder...
October 2021: Chirurgia
https://read.qxmd.com/read/34700824/a-survey-of-breast-cancer-patients-use-of-cannabis-during-radiation-therapy
#22
JOURNAL ARTICLE
M Weiss, S Danese, K Aliano Ruiz, S Kjelstrom, M Buckley, A Leitenberger, M Bollmann-Jenkins, S Larson, A S DeNittis, D Martinez
PURPOSE/OBJECTIVE(S): Cannabis use is rapidly expanding and cancer is a qualifying condition in all 33 states allowing medical cannabis. However, the patterns of cannabis use among breast cancer patients receiving radiation therapy is unknown. The goal of this study was to better understand how and why cannabis is used among breast cancer patients undergoing adjuvant and palliative radiation therapy. MATERIALS/METHODS: Between 12/16/2019 and 1/19/2020, U.S.-based members of the Breastcancer...
November 1, 2021: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/34636036/a-coala-t-cannabis-survey-study-of-breast-cancer-patients-use-of-cannabis-before-during-and-after-treatment
#23
JOURNAL ARTICLE
Marisa C Weiss, Julianne E Hibbs, Meghan E Buckley, Sherry R Danese, Adam Leitenberger, Melissa Bollmann-Jenkins, Sam W Meske, Katherine E Aliano-Ruiz, Theresa W McHugh, Sharon L Larson, Elaine H Le, Nancye L Green, Paul B Gilman, Virginia G Kaklamani, Rowan T Chlebowski, Diana M Martinez
BACKGROUND: The goal of this study was to characterize cannabis use among patients with breast cancer, including their reasons for and timing of use, their sources of cannabis information and products, their satisfaction with the information found, their perceptions of its safety, and their dialogue about cannabis with their physicians. METHODS: United States-based members of the Breastcancer.org and Healthline.com communities with a self-reported diagnosis of breast cancer within 5 years (age ≥ 18 years) were invited to participate in an anonymous online survey...
January 1, 2022: Cancer
https://read.qxmd.com/read/34346656/-are-the-netherlands-ready-for-personalized-breast-cancer-screening-abbreviated-breast-mri-and-contrast-enhanced-mammography-for-screening-in-women-with-dense-breasts
#24
JOURNAL ARTICLE
H P J Raat, M B I Lobbes, W B Veldhuis
One-size-fits-all breast cancer screening no longer reflects the current state of knowledge and technology. 8% of the participants in the Dutch Breastcancer Screening Program have extremely dense breasts, which is coupled to a strongly increased risk of breast cancer. In addition, for this group of approximately 80,000 women per year, mammography is only 60% sensitive. The DENSE trial showed that supplemental MRI after a negative mammogram reduced the number of interval cancers by more than 80%. The Dutch Health Council however subsequently recommended to consider contrast-enhanced mammography (CEM) as a screening tool...
July 29, 2021: Nederlands Tijdschrift Voor Geneeskunde
https://read.qxmd.com/read/34057115/gata-3-and-ki-67-expression-in-correlation-with-molecular-subtypes-of-breast-cancer
#25
COMPARATIVE STUDY
M Husni Cangara, Upik A Miskad, Rina Masadah, Berti J Nelwan, Syarifuddin Wahid
OBJECTIVES: This study aims to evaluate and compare four breast cancer subtypes defined by immunohistochemistry expression of ER, PR, and HER-2 in correlation with Ki-67 and GATA-3 expression. METHODS: Slides from 89 paraffin blocks of invasive breast cancer patients with four molecular subtypes based on HER-2, ER, and PR expression were then stained with Ki-67 and GATA-3 antibodies to evaluate their expression in correlation with molecular subtype and metastases to lymph nodes...
2021: Breast Disease
https://read.qxmd.com/read/33963701/use-of-a-tumor-bed-boost-in-the-radiotherapy-after-oncoplastic-breast-conserving-surgery
#26
JOURNAL ARTICLE
Liviu Stoleru, Smaranda Stoleru, Bogdan Gaspar, Aniela Noditi, Alexandru Blidaru
Use of a radiotherapy (RT) tumor bed boost in addition to whole breast irradiation (WBI) after oncoplastic breast conserving surgery (OBCS) can be very challenging due to the massive tissue displacements. The aim of our study is to present relevant RT data regarding the use of a boost RT in patients who underwent OBCS and received adjuvant RT at Neolife Medical Center Bucharest. Materials and Methods: 12 patients treated with intensity modulated radiotherapy (IMRT), after OBCS, using conventional or hypofractionated schedules, between 10/2018 and 12/2020 were included in the study...
March 2021: Chirurgia
https://read.qxmd.com/read/33963700/experience-of-the-prof-dr-panait-sarbu-hospital-in-oncofertility-among-breast-cancer-patients
#27
JOURNAL ARTICLE
Ioana Iordache, Cristiana Odukoya, Andreea Carp-Veliscu, Alina Elena Bordea, Elvira Bratila
Introduction: Oncofertility represents a new field, dedicated to patients at childbearing age who are diagnosed with a neoplasic disease and who want to have a biologic child after they complete the oncological and surgical treatment. Because of new screening and treatment methods, most patients survive the disease, but the main long-term complication remains infertility. Young women with breast cancer are candidates for preserving their fertility mostly because of the risk of chemotherapy-related infertility due to the alkylating agent, causing dose-dependent destruction of oocytes and follicular depletion and thus bringing cortical fibrosis and ovarian blood-vessel damage (1)...
March 2021: Chirurgia
https://read.qxmd.com/read/33963699/6-years-of-breast-reconstruction-in-one-center-an-objective-analysis
#28
JOURNAL ARTICLE
Daniela Elena Gheoca, Adelaida Avino, Laura Raducu, Cristina Nicoleta Marina, Maria Corina Stefan, Luminita Florentina Tomescu, Adrian Daniel Tulin, Cristian Radu Jecan
Background: Breast cancer represents the most common type of neoplasm in women around the world. Breast reconstruction following mastectomy has become a demanding procedure in the treatment of patients suffering from breast cancer. Their major role is to improve the quality of life of women, leading to better aesthetic outcomes. Based on each type of reconstruction, the complications following surgery and the duration of hospital stay, the financial implications slightly vary. Methods: Our study included 168 female patients who underwent immediate or delayed breast reconstruction after mastectomy...
March 2021: Chirurgia
https://read.qxmd.com/read/33963697/tiloop-bra-assisted-breast-reconstruction-our-experience
#29
JOURNAL ARTICLE
Petr Vladimirovich Krivorotko, Roman Sergeevich Pesotsky, Konstantin Yurevich Zernov, Elena Konstantinovna Zhiltsova, Tengiz Tengizovich Tabagua, Alexander Alexeevich Bessonov, Alexander Valeryavich Komyahov, Kiriil Stanislavovich Nikolaev, Kirill Yurevich Rychagov, Larisa Pavlovna Gigolaeva, Konstantin Yurevich Zirov, Zalina Alibekovna Aseeva, Alexander Sergeevich Emelyanov, Diana Arturovna Enaldieva, Yana Igorevna Bondarchuk, Valeriy Evgenevich Levchenko, Alexey Mikhaloivich Belyaev, Vladimir Fedorovich Semiglazov
Additional covering of the lower pole with allomaterial or its synthetic analogues during immediate breast reconstruction is being perfomed at the N.N. Petrov National Medical Research Oncology Center, Ministry of Healthcare of Russian Federation for last 7 years. Initially, epidermal flap was the only option for lower pole coverage, later ADM was used as part of clinical approbation. Average complication rate ranges from 20-35% due to blood circulatory (supply) disorders. Since 2018, a titanized mesh (TiLoop Bra) been used as a additional coverage of the lower pole...
March 2021: Chirurgia
https://read.qxmd.com/read/33963696/contralateral-prophylactic-mastectomy-in-patients-with-breast-cancer
#30
JOURNAL ARTICLE
Aniela Noditi, George Caragheorghe, Smaranda Stoleru, Alexandru Blidaru, Cristian Ioan Bordea
Introduction: The rate of contralateral prophylactic mastectomy (CPM) increased within the recent years. The main reasons are: genetic testing, availability of breast reconstruction, more often use of preoperative breast MRI, improvement of postoperative aesthetic results and reimbursement of breast reconstruction. The purpose of this study was to analyze the indication of CPM, it's evolution and the surgical techniques used for this type of surgery. Materials and methods: This prospective study enrolled patients with unilateral breast cancer for which conservative treatment was not an option and underwent CPM concomitant with therapeutic mastectomy, using different techniques, followed by immediate breast reconstruction using alloplastic materials...
2021: Chirurgia
https://read.qxmd.com/read/33963691/the-intricate-relationship-between-melatonin-and-breast-cancer-a-short-review
#31
JOURNAL ARTICLE
Lida Pistioli, Dimitrios Katsarelias, Riccardo A Audisio, Roger Olofsson Bagge
Melatonin is a relatively recently isolated hormone, produced by the pineal gland. Its implication in several cell functions has augmented interest from scientists worldwide. There is ongoing research investigating the deterrent relationship between melatonin and malignancies and in particular breast cancer. The aim of this article is to review some of the most important findings concerning the effect of melatonin on cancer biology, from both preclinical and clinical studies providing an insight to the complex biological actions of this molecule, as well as their potential significance...
March 2021: Chirurgia
https://read.qxmd.com/read/33963690/risk-factor-analysis-for-flap-and-donor-site-related-complications-in-1274-diep-flaps-retrospective-single-center-study
#32
JOURNAL ARTICLE
Sonia Fertsch, Beatrix Munder, Christoph Andree, Christian Witzel, Peter Stambera, Tino Schulz, Mazen Hagouan, Lukas Gruter, Birgit Aufmesser, Katinka Staemmler, Julia Kornetka, Mohammed Aldeeri, Katrin Seidenstucker, Alina Abu-Ghazaleh, Andreas Wolter
Background: Breast cancer is the most common cancer affecting women worldwide. In Germany, in almost 70% of cases, women require a complete mastectomy and wish for breast reconstruction which is especially difficult when the breast was previously irradiated. The DIEP flap is then the gold standard for autologous breast reconstruction and shows an overall low complication rate. This study aims to underline the safety of the procedure yet point out potential risk factors for flap edge and fat necrosis in a retrospective series of 1274 DIEP flaps in our center...
March 2021: Chirurgia
https://read.qxmd.com/read/33950820/patient-reported-quality-of-life-3-months-after-breast-reconstruction
#33
JOURNAL ARTICLE
Adelaida Avino, Daniela Elena Gheoca-Mutu, Laura Raducu, Sorin Andrei Nedelea, Cristian Radu Jecan, Ioan Lascar
Background: Breast cancer is considered to be the second major cause of cancer death in women after lung cancer. Due to a remarkable progress, the treatments against breast cancer became more efficient and less toxic. In addition, the reconstructive procedures after mastectomy have improved significantly the quality of life especially in younger women. The aim of the study was to evaluate the quality of life of patients 3 months after breast reconstruction. Methods: We performed a prospective study on 25 female patients who underwent immediate or delayed reconstruction of the breast after mastectomy...
March 2021: Chirurgia
https://read.qxmd.com/read/33950817/the-effect-of-menstrual-cycle-phase-on-the-prognostic-factors-in-patients-with-premenopausal-breast-tumors
#34
JOURNAL ARTICLE
Berrin Papila Kundaktepe, Sinem Durmus, Cigdem Papila, Mehmet Velidedeoglu, Remise Gelisgen, Hafize Uzun
Background: Estrogen receptor and progesterone receptor positivity and c-erbB2 gene expression levels are important in determining breast cancer development and aggression. Although the importance of hormonal factors in tumor cell proliferation, migration and differentiation is increasing, it needs more evidence. The effect of BC surgery timing during the menstrual cycle on prognosis remains controversial. In order to clarify this hypothesis, we aimed to determine the importance of adjusting the timing of surgery according to the menstrual cycle by examining the relationship between estrogen receptor, progesterone receptor, c-erbB2 gene and the menstrual cycle phase in patients with premenopausal breast cancer...
2021: Chirurgia
https://read.qxmd.com/read/33950814/the-management-of-axillary-lymph-nodes-in-breast-cancer-a-retrospective-single-centre-study
#35
JOURNAL ARTICLE
Elena Mihaela Vrabie, Mihnea Alecu, Ciprian Cirimbei, Claudiu Daha, Virgiliu Mihail Prunoiu, Dana Lucia Stanculeanu, Daniela Zob, Alexandra Baciu, Ina Petrescu, Laurentiu Simion
Introduction: We are presenting the experience of our centre with the surgical treatment of breast cancer, by comparing the use of axillary node dissection with sentinel lymph node biopsy (SNLB). Methods: We have made a retrospective analysis of breast cancer cases in the Surgical Oncology Clinic no. 1, "Alexandru Trestioreanu" Oncology Institute, Bucharest, in the period between December 2019 and December 2020. We are presenting the situations in which axillary node dissection can be replaced with SNLB and the limitations of this method...
March 2021: Chirurgia
https://read.qxmd.com/read/33950813/sentinel-lymph-node-biopsy-after-neoadjuvant-treatment-for-breast-cancer-the-validation-protocol
#36
JOURNAL ARTICLE
Cristian Bordea, Mirela Gherghe, Cristina Capsa, Aniela Noditi, Ciprian Ianovici, George Caragheorghe, Alexandru Blidaru
Introduction: The identification and biopsy of the sentinel lymph node (SLNB) in breast cancer patients requiring neoadjuvant cytostatic treatment (NAC), with clinically negative lymph nodes following treatment, may be an effective method of de-escalation of axillary surgery. Materials and methods: This prospective study includes 47 cases of breast cancer stage IIB-IIIA, with NAC treatment and complete axillary clinical and imaging response, surgeries performed at Prof. Dr. Alexandru Trestioreanu Oncological Institute in Bucharest (IOB) by the same team...
March 2021: Chirurgia
https://read.qxmd.com/read/33950812/breast-cancer-apoptosis-and-the-therapeutic-role-of-luteolin
#37
JOURNAL ARTICLE
Zacharias Fasoulakis, Antonios Koutras, Athanasios Syllaios, Dimitrios Schizas, Nikolaos Garmpis, Michail Diakosavvas, Kyveli Angelou, Georgios Tsatsaris, Athanasios Pagkalos, Thomas Ntounis, Emmanuel N Kontomanolis
Breast cancer represents one of the three most common gynecological cancers, with each subtype having distinct risk profile and treatment strategies. Optimal therapy for each case depends not only on tumor subtype and cancer stage, but also on patient preferences. Thus, the final therapeutic choice seems complicated to be reached. In addition, frequent relapses and the aesthetic effects have led to the search for more effective and less invasive methods. Surgical interventions have become less complex and new hormonal and chemotherapeutic drugs are established, that promise great results, either combined to surgical treatment or used exclusively...
March 2021: Chirurgia
https://read.qxmd.com/read/33950811/a-better-understanding-of-axillary-lymph-node-dissection-in-the-era-of-sentinel-lymph-node-biopsy
#38
JOURNAL ARTICLE
Silviu Cristian Voinea, Angela Sandru, Cristian Ioan Bordea, Aniela Noditi, Lacramioara Paula Borangic, Alexandru Blidaru
Axillary lymph node dissection (ALND) was and still is an important part of breast cancer treatment despite the fact the sentinel lymph node biopsy (SLNB) has revolutionized breast cancer surgery. SLNB provides the same prognostic information as ALND but with significantly less morbidity. The results of numerous trials conducted over the past 20 years have crowned SLNB as the gold standard for early breast cancer treatment. ALND represents a very standardized intervention with precise landmarks and boundaries...
March 2021: Chirurgia
https://read.qxmd.com/read/33950810/palliative-toilet-mammectomy-a-decision-making-dilemma-short-review
#39
JOURNAL ARTICLE
Adrian Constantin, Dragos Predescu, Ruxandra Ciofu, Florin Achim, Silviu Constantinoiu
Breast cancer is one of the most severe health issues globally, but the therapy advancements and the constant adaptation of treatment protocols radically changed its prognoses. This article review of the literature from a surgical perspective, thus allowing for the optimum detection and placement of its role and benefits in the surgical and oncology therapeutics. The role of surgery becomes controversial, with sometimes "pretentious" techniques, hard to quantify benefits and challenges that require a thorough assessment prior to opting for surgery...
March 2021: Chirurgia
https://read.qxmd.com/read/33950809/surgical-management-of-the-breast-and-axilla-after-neoadjuvant-therapy
#40
JOURNAL ARTICLE
Dan Hershko
The indications for the use of neoadjuvant chemotherapy (NAC) for the management of breast cancer have broadened immensely in recent years. Initially intended mostly for inoperable breast cancers, this modality has then became the standard of care for locally advanced cancers. This treatment allowed safe surgical margin resection and in many patients with large tumors it allowed breast conserving surgery, avoiding the need for mastectomy. As clinical experience with NAC has increased along with the introduction of novel medications and better understanding of tumor biology, the indications for its use have become even more common for the treatment of some subtypes of early breast cancer...
March 2021: Chirurgia
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