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https://www.readbyqxmd.com/read/27639886/-prolactin-antipsychotics-and-breast-cancer-is-there-a-connection
#1
T Sabbe, J Detraux, M De Hert
BACKGROUND: The use of antipsychotics can result in elevated prolactin levels or hyperprolactinemia. An increasing number of studies suggests that prolactin plays a role in mammary carcinogenesis, leading to concerns about a possible relationship between antipsychotics and breast cancer.<br/> AIM: To provide an overview of recent literature regarding the relationship between prolactin, antipsychotics and breast cancer and an association between schizophrenia and breast cancer...
2016: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/27456970/comparison-of-the-her2-estrogen-and-progesterone-receptor-expression-profile-of-primary-tumor-metastases-and-circulating-tumor-cells-in-metastatic-breast-cancer-patients
#2
Bahriye Aktas, Sabine Kasimir-Bauer, Volkmar Müller, Wolfgang Janni, Tanja Fehm, Diethelm Wallwiener, Klaus Pantel, Mitra Tewes
BACKGROUND: The expression of HER2, estrogen (ER) and progesterone (PR) receptor can change during the course of the disease in breast cancer (BC). Therefore, reassessment of these markers at the time of disease progression might help to optimize treatment decisions. In this context, characterization of circulating tumor cells (CTCs) could be of relevance since metastatic tissue may be difficult to obtain for repeated analysis. Here we compared HER2/ER/PR expression profiles of primary tumors, metastases and CTCs...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27212060/different-prognostic-value-of-circulating-and-disseminated-tumor-cells-in-primary-breast-cancer-influence-of-bisphosphonate-intake
#3
Sabine Kasimir-Bauer, Katharina Reiter, Bahriye Aktas, Ann-Kathrin Bittner, Stephan Weber, Thomas Keller, Rainer Kimmig, Oliver Hoffmann
Disseminated tumor cells (DTCs) in the bone marrow (BM) and circulating tumor cells (CTCs) in blood of breast cancer patients (pts) are known to correlate with worse outcome. Here we demonstrate a different prognostic value of DTCs and CTCs and explain these findings by early clodronate intake. CTCs (n = 376 pts) were determined using the AdnaTest BreastCancer (Qiagen Hannover GmbH, Germany) and DTCs (n = 525 pts) were analyzed by immunocytochemistry using the pan-cytokeratin antibody A45-B/B3. Clodronate intake was recommended in case of DTC-positivity...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26989051/male-breast-cancer-is-not-congruent-with-the-female-disease
#4
REVIEW
Ian S Fentiman
It has become customary to extrapolate from the results of treatment trials for female breastcancer and apply them to males with the disease. In the absence of results from national and international randomised trials for male breast cancer (MBC) this appears superficially to be an appropriate response. Closer examination of available data reveals that aspects of the aetiology and treatment of MBC do not fit the simplistic model that men usually have endocrine sensitive tumours which behave like those in postmenopausal women...
May 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/26868521/does-primary-neoadjuvant-systemic-therapy-eradicate-minimal-residual-disease-analysis-of-disseminated-and-circulating-tumor-cells-before-and-after-therapy
#5
Sabine Kasimir-Bauer, Ann-Kathrin Bittner, Lisa König, Katharina Reiter, Thomas Keller, Rainer Kimmig, Oliver Hoffmann
BACKGROUND: Patients with breast cancer (BC) undergoing neoadjuvant chemotherapy (NACT) may experience metastatic relapse despite achieving a pathologic complete response. We analyzed patients with BC before and after NACT for disseminated tumor cells (DTCs) in the bone marrow(BM); comprehensively characterized circulating tumor cells (CTCs), including stem cell-like CTCs (slCTCs), in blood to prove the effectiveness of treatment on these cells; and correlated these findings with response to therapy, progression-free survival (PFS), and overall survival (OS)...
February 12, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/26669679/rejection-of-breast-reconstruction-among-lesbian-breast-cancer-patients
#6
Rachael L Wandrey, Whitney D Qualls, Katie E Mosack
PURPOSE: After having breast cancer (BC) and being treated by mastectomy, patients typically struggle with decisions about reconstruction. It is unclear how lesbian-identified women think about breast reconstruction. The purpose of this study was to explore lesbian BC survivors' attitudes toward breast reconstruction. This study represents the first published study to analyze data from a lesbian-specific BC forum to evaluate such attitudes. METHODS: We conducted an inductive thematic analysis of breast reconstruction discussions among individuals who posted to a lesbian-specific online support forum found on breastcancer...
December 15, 2015: LGBT Health
https://www.readbyqxmd.com/read/25737993/angiogenesis-in-breast-cancer-and-its-correlation-with-estrogen-progesterone-receptors-and-other-prognostic-factors
#7
Jyotsna Naresh Bharti, Poonam Rani, Vinay Kamal, Prem Narayan Agarwal
PURPOSE: The aim of study is to evaluate angiogenesis using CD34, in estrogen, progesterone positive and negative breastcancer and to correlate the microvessel density with known histological prognostic factors, morphological type of breast carcinoma and lymph node metastasis. MATERIALS AND METHODS: Twenty eight untreated cases of breast cancer were included in the study and paraffin embedded sections were obtained from representative mastectomy specimen of breast cancer patient...
January 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25250105/the-effect-of-surveillance-on-the-outcome-of-breast-cancer-patients
#8
Kazem Anvari, Azar Fanipakdel, Yasmin Davoudi
BACKGROUND: The beginning of metastasis poorly affects the prognosis of breastcancer patients. Lung is the most frequent site of visceral metastasis, and the rate of recurrence is 10-30%. We have tried to find out if the routine Chest X Ray (CXR) could play a role for early detection of lung metastasis, during the prognosis of these patients. METHODS: The files of the breast cancer patients between 1996 to 2006 (1739 patients) have reviewed. Clinical characteristics of patients with pulmonary metastasis have recorded...
2013: Iranian Journal of Cancer Prevention
https://www.readbyqxmd.com/read/25108406/detection-of-disseminated-tumor-cells-in-bone-marrow-and-circulating-tumor-cells-in-blood-of-patients-with-early-stage-male-breast-cancer
#9
Mitra Tewes, Sabine Kasimir-Bauer, Anja Welt, Martin Schuler, Rainer Kimmig, Bahriye Aktas
BACKGROUND: Male breast cancer (MBC) is a rare malignant disease, accounting for <1% of all breast cancers (BCs). Treatment of men with early-stage BC is based on standards established in female BC. Prognostic or predictive markers to guide therapeutic decisions, in particular in early-stage male BC, are missing. Here, we explored whether disseminated tumor cells (DTC) in bone marrow (BM) and circulating tumor cells (CTC) in blood could be suitable biomarkers in male BC. PATIENTS AND METHODS: Five male patients (pT2-4, pN0-2, M0) with hormone receptor-positive, HER2-negative, and ductal primary BC (median age 70 years, range 51-73) were enrolled in a prospective study of patients with early-stage breast cancer...
January 2015: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/24947101/icon-2013-practical-consensus-recommendations-for-hormone-receptor-positive-her2-negative-advanced-or-metastatic-breastcancer
#10
P M Parikh, S Gupta, S Dawood, H Rugo, G S Bhattacharyya, A Agarwal, R Chacko, T P Sahoo, G Babu, S Agarwal, A Munshi, C Goswami, B K Smruti, S Bondarde, C Desai, S Rajappa, N Somani, M Singh, R Nimmagadda, K Pavitran, A Mehta, V Parmar, S Desai, R Nair, D Doval
The management of hormone receptor-positive Her2-negative breast cancer patients with advanced or metastatic disease is a common problem in India and other countries in this region. This expert group used data from published literature, practical experience, and opinion of a large group of academic oncologists, to arrive at practical consensus recommendations for use by the community oncologists.
January 2014: Indian Journal of Cancer
https://www.readbyqxmd.com/read/24649291/evaluation-and-correlation-of-risk-recurrence-in-early-breast-cancer-assessed-by-oncotype-dx-%C3%A2-clinicopathological-markers-and-tumor-cell-dissemination-in-the-blood-and-bone-marrow
#11
Bahriye Aktas, Agnes Bankfalvi, Martin Heubner, Rainer Kimmig, Sabine Kasimir-Bauer
The Oncotype DX(®) assay is a validated genomic test that predicts the likelihood of breast cancer recurrence, patient survival within ten years of diagnosis and the benefit of chemotherapy in early-stage, node-negative, estrogen receptor-positive breast cancer. Further markers of recurrence include disseminated tumor cells (DTCs) in the bone marrow (BM) and circulating tumor cells (CTCs) in the blood, particularly stemness-like tumor cells (slCTCs). In this study, Oncotype DX, DTCs, CTCs and slCTCs were used to evaluate the risk of recurrence in 68 patients with human epidermal growth factor receptor 2-negative, early-stage breast cancer...
November 2013: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/24350991/detection-of-circulating-tumor-cells-during-follow-up-of-patients-with-early-breast-cancer-clinical-utility-for-monitoring-of-therapy-efficacy
#12
Veronika Mikulová, Michaela Cabiňaková, Ivana Janatková, Otto Mestek, Tomáš Zima, Petra Tesařová
INTRODUCTION: Circulating tumor cells (CTCs) detection prior to and during therapy is considered as an independent and strong prognostic marker. The present study was designed to isolate and characterize CTCs in peripheral blood of an early breast cancer (BC) patient as a biomarker for monitoring treatments efficacy. MATERIALS AND METHODS: In total, 54 early breast cancer patients undergoing neoadjuvant and/or adjuvant chemotherapy regimens were enrolled into a prospective study...
March 2014: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/24349790/staging-investigations-in-breast-cancer-collective-opinion-of-uk-breast-surgeons
#13
N Chand, R I Cutress, R S Oeppen, A Agrawal
Introduction. Certain clinicopathological factors are associated with a higher likelihood of distant metastases in primary breast cancer. However, there remains inconsistency in which patients undergo formal staging for distant metastasis and the most appropriate investigation(s). Aims. To identify UK surgeon preferences and practice with regard to staging investigations for distant metastases. Methods. A survey was disseminated to members of the Association of Breast Surgery by e-mail regarding surgeon/breast unit demographics, use of staging investigations, and local policy on pre/postoperative staging investigations...
2013: International Journal of Breast Cancer
https://www.readbyqxmd.com/read/23497487/comparison-of-three-molecular-assays-for-the-detection-and-molecular-characterization-of-circulating-tumor-cells-in-breast-cancer
#14
COMPARATIVE STUDY
Areti Strati, Sabine Kasimir-Bauer, Athina Markou, Cleo Parisi, Evi S Lianidou
INTRODUCTION: Comparison studies between different analytical methodologies for circulating tumor cells (CTC) detection and molecular characterization are urgently needed, since standardization of assays is essential before their use in clinical practice. METHODS: We compared three different CTC molecular assays. To avoid discrepancies due to pre-analytical errors we used the same cDNAs throughout our study. CTC were isolated using anti-EpCAM and anti-MUC1 coated magnetic beads from 2 × 5 ml of peripheral blood of 254 early and 51 metastatic breast cancer patients and 30 healthy individuals...
March 7, 2013: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/22936393/a-phoenix-rising-who-considers-herself-a-survivor-after-a-diagnosis-of-breast-cancer
#15
Christina H Jagielski, Sarah T Hawley, Kimberly Corbin, Marisa C Weiss, Jennifer J Griggs
PURPOSE: The purpose of this study is to investigate factors associated with patients' identification of themselves as survivors after a diagnosis of breast cancer. METHODS: A self-administered survey was deployed through the nonprofit organization Breastcancer.org . As part of a larger study, we collected data on treatment, mental health, perceived prognosis, concerns about recurrence, and the question, "Do you consider yourself a survivor of breast cancer?" RESULTS: Of the 629 survey respondents, 492 (78 %) considered themselves survivors of breast cancer...
December 2012: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/22264265/expression-of-stem-cell-and-epithelial-mesenchymal-transition-markers-in-primary-breast-cancer-patients-with-circulating-tumor-cells
#16
Sabine Kasimir-Bauer, Oliver Hoffmann, Diethelm Wallwiener, Rainer Kimmig, Tanja Fehm
INTRODUCTION: The presence of circulating tumor cells (CTC) in breast cancer might be associated with stem cell-like tumor cells which have been suggested to be the active source of metastatic spread in primary tumors. Furthermore, to be able to disseminate and metastasize, CTC must be able to perform epithelial-mesenchymal transition (EMT). We studied the expression of three EMT markers and the stem cell marker ALDH1 in CTC from 502 primary breast cancer patients. Data were correlated with the presence of disseminated tumor cells (DTC) in the bone marrow (BM) and with clinicopathological data of the patients...
2012: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/21613958/molecular-profiling-and-prognostic-relevance-of-circulating-tumor-cells-in-the-blood-of-ovarian-cancer-patients-at-primary-diagnosis-and-after-platinum-based-chemotherapy
#17
Bahriye Aktas, Sabine Kasimir-Bauer, Martin Heubner, Rainer Kimmig, Pauline Wimberger
OBJECTIVES: Disseminated tumor cells (DTCs) in the bone marrow (BM) were shown to be of prognostic significance in gynecological cancers. Bone marrow aspiration is less accepted by patients compared with blood drawing. In this pilot study, we applied the AdnaTest BreastCancer based on immunomagnetic enrichment, targeting common antigens on epithelial gynecological cancers, followed by multiplex reverse transcriptase-polymerase chain reaction for selection and detection of circulating tumor cells (CTCs) in the blood of 122 ovarian cancer patients at primary diagnosis and/or after platinum-based chemotherapy...
July 2011: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/21469140/comparison-of-assay-methods-for-detection-of-circulating-tumor-cells-in-metastatic-breast-cancer-adnagen-adnatest-breastcancer-select-detect%C3%A2-versus-veridex-cellsearch%C3%A2-system
#18
E Andreopoulou, L-Y Yang, K M Rangel, J M Reuben, L Hsu, S Krishnamurthy, V Valero, H A Fritsche, M Cristofanilli
The detection of CTCs prior to and during therapy is an independent and strong prognostic marker, and it is predictive of poor treatment outcome. A major challenge is that different technologies are available for isolation and characterization of CTCs in peripheral blood (PB). We compare the CellSearch system and AdnaTest BreastCancer Select/Detect, to evaluate the extent that these assays differ in their ability to detect CTCs in the PB of MBC patients. CTCs in 7.5 ml of PB were isolated and enumerated using the CellSearch, before new treatment...
April 1, 2012: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/20859679/her2-status-of-circulating-tumor-cells-in-patients-with-metastatic-breast-cancer-a-prospective-multicenter-trial
#19
MULTICENTER STUDY
Tanja Fehm, Volkmar Müller, Bahriye Aktas, Wolfgang Janni, Andreas Schneeweiss, Elmar Stickeler, Claus Lattrich, Christian R Löhberg, Erich Solomayer, Brigitte Rack, Sabine Riethdorf, Christoph Klein, Christian Schindlbeck, Kerstin Brocker, Sabine Kasimir-Bauer, Diethelm Wallwiener, Klaus Pantel
There is a growing body of evidence that HER2 status can change during disease recurrence or progression in breast cancer patients. In this context, re-evaluation of HER2 status by assessment of HER2 expression on circulating tumor cells (CTCs) is a strategy with potential clinical application. The aim of this trial was to determine the HER2 status of CTCs in metastatic breast cancer patients comparing two CTC assays. A total of 254 patients with metastatic breast cancer from nine German university breast cancer centers were enrolled in this prospective study...
November 2010: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/20525248/a-multilevel-data-integration-resource-for-breast-cancer-study
#20
Ettore Mosca, Roberta Alfieri, Ivan Merelli, Federica Viti, Andrea Calabria, Luciano Milanesi
BACKGROUND: Breast cancer is one of the most common cancer types. Due to the complexity of this disease, it is important to face its study with an integrated and multilevel approach, from genes, transcripts and proteins to molecular networks, cell populations and tissues. According to the systems biology perspective, the biological functions arise from complex networks: in this context, concepts like molecular pathways, protein-protein interactions (PPIs), mathematical models and ontologies play an important role for dissecting such complexity...
2010: BMC Systems Biology
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