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Depression medicine

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https://www.readbyqxmd.com/read/29341893/targeting-bdnf-modulation-by-plant-glycosides-as-a-novel-therapeutic-strategy-in-the-treatment-of-depression
#1
REVIEW
Haroon Khan, Surriya Amin, Seema Patel
Current therapies in clinical practice face strong criticism regarding their efficacy, and side effects, which forced the neuro-researchers to discover novel agents with different mechanistic insights. Glycosides are naturally-occurring plant secondary metabolites with significant medicinal potential and clinical scope as antidepressant. The aim of this review is to focus on the antidepressant effects of glycosides in preclinical studies, with an emphasis on the possible mechanisms. The literature search revealed that only a few phytoglycosides have been evaluated for their relevance in depression alleviation...
January 13, 2018: Life Sciences
https://www.readbyqxmd.com/read/29340941/internal-medicine-residents-attitudes-toward-simulated-depressed-cardiac-patients-during-an-objective-structured-clinical-examination-a-randomized-study
#2
Kathleen Crapanzano, Dixie Fisher, Rebecca Hammarlund, Eric P Hsieh, Win May
BACKGROUND: Physician biases toward mental conditions such as depression have been shown to adversely affect medical outcomes. OBJECTIVE: To explore the relationship between residents' explicit bias toward depressed patients and their clinical skills on a cardiac case during an objective structured clinical exam (OSCE). DESIGN: Prospective parallel randomized controlled study. PARTICIPANTS: One hundred eighty-five internal medicine residents from three residency programs in two states...
January 16, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29335210/privileged-scaffolds-as-mao-inhibitors-retrospect-and-prospects
#3
REVIEW
Avinash C Tripathi, Savita Upadhyay, Sarvesh Paliwal, Shailendra K Saraf
This review aims to be a comprehensive, authoritative, critical, and readable review of general interest to the medicinal chemistry community because it focuses on the pharmacological, chemical, structural and computational aspects of diverse chemical categories as monoamine oxidase inhibitors (MAOIs). Monoamine oxidases (MAOs), namely MAO-A and MAO-B represent an enormously valuable class of neuronal enzymes embodying neurobiological origin and functions, serving as potential therapeutic target in neuronal pharmacotherapy, and hence we have coined the term "Neurozymes" which is being introduced for the first time ever...
January 4, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29332222/efficacy-of-crocus-sativus-saffron-in-treatment-of-major-depressive-disorder-associated-with-post-menopausal-hot-flashes-a-double-blind-randomized-placebo-controlled-trial
#4
Ladan Kashani, Sophia Esalatmanesh, Farzaneh Eftekhari, Samrand Salimi, Tahereh Foroughifar, Farnaz Etesam, Hamideh Safiaghdam, Ehsan Moazen-Zadeh, Shahin Akhondzadeh
PURPOSE: Due to concerns regarding the side effects of hormone therapy, many studies have focused on the development of non-hormonal agents for treatment of hot flashes. The aim of this study was to evaluate the efficacy and safety of saffron (stigma of Crocus sativus) in treatment of major depressive disorder associated with post-menopausal hot flashes. METHODS: Sixty women with post-menopausal hot flashes participated in this study. The patients randomly received either saffron (30 mg/day, 15 mg twice per day) or placebo for 6 weeks...
January 13, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29329045/increased-depression-symptom-score-in-newly-diagnosed-type-2-diabetes-patients
#5
Wolfgang Rathmann, Oliver Kuß, Dörte Anderson, Stefan Busch, Michael Hahn, Johanna Engelhard, Ming Zou, Karel Kostev
The aim was to investigate the association between diabetes duration and depressive symptoms in type 2 diabetes. The DIAREG registry used data of a nationwide general medicine practice database (Disease Analyzer, Germany) augmented by prospective data from patient reported outcomes (PRO) including Center of Epidemiological Studies Depression Scale (CES-D: <16 vs. ≥16) and the SF-36. Multiple logistic regression models were used to investigate the association of diabetes duration with PROs. Overall, 1807 type 2 diabetes patients were registered in 108 practices...
January 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29325731/pharmacogenomic-testing-in-child-and-adolescent-psychiatry-an-evidence-based-review
#6
Anna M Wehry, Laura Ramsey, Shane E Dulemba, Sarah A Mossman, Jeffrey R Strawn
Significant advances have been made in the application of pharmacogenomic testing for the treatment of patients with psychiatric disorders. Over the past decade, a number of studies have evaluated the utility of pharmacogenomic testing in pediatric patients with psychiatric disorders. The evidence base for pharmacogenomic testing in youth with depressive and anxiety disorders as well as attention/deficit hyperactivity disorder (ADHD) is reviewed in this article. General pharmacogenomic principles are summarized and functional polymorphisms in P450 enzymes (and associated metabolizer phenotypes), the serotonin transporter promoter polymorphisms, serotonin 2 A receptor genes (e...
January 8, 2018: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/29323042/mitochondrial-protective-and-anti-apoptotic-effects-of-rhodiola-crenulata-extract-on-hippocampal-neurons-in-a-rat-model-of-alzheimer-s-disease
#7
Jun-Mei Wang, Ze-Qiang Qu, Jin-Lang Wu, Peter Chung, Yuan-Shan Zeng
In our previous study, we found that the edible alcohol extract of the root of the medicinal plant Rhodiola crenulata (RCE) improved spatial cognition in a rat model of Alzheimer's disease. Another study from our laboratory showed that RCE enhanced neural cell proliferation in the dentate gyrus of the hippocampus and prevented damage to hippocampal neurons in a rat model of chronic stress-induced depression. However, the mechanisms underlying the neuroprotective effects of RCE are unclear. In the present study, we investigated the anti-apoptotic effect of RCE and its neuroprotective mechanism of action in a rat model of Alzheimer's disease established by intracerebroventricular injection of streptozotocin...
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29321706/validity-and-reliability-of-the-turkish-version-of-the-multiple-sclerosis-related-symptom-checklist
#8
Zeliha Tülek, Cansu Polat, Murat Kürtüncü, Mefkure Eraksoy
Introduction: Multiple sclerosis (MS) is a disease that causes different symptoms in each attack and has an individual-specific course. Detailed questioning and recording of MS symptoms is important for developing a management plan for individual-specific symptoms. The present study was planned to evaluate the validity and reliability of the Turkish version of "Multiple Sclerosis-Related Symptom Checklist" (MS-RS), which has been developed for patients to personally follow-up the symptoms they experience...
December 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29321123/comparative-analysis-of-women-with-notable-subjective-health-indicators-compared-with-participants-in-the-australian-longitudinal-study-on-women-s-health-cross-sectional-survey
#9
Christoph Schnelle, Eunice J Minford, Vanessa McHardy, Jane Keep
BACKGROUND: At least six communities with unusually good health and longevity have been identified, but their lifestyles aren't adopted widely. Informal evidence suggests that women associated with Universal Medicine (UM), a complementary medicine health care organization in Eastern Australia and the United Kingdom with normal lifestyles, also have several unusual health indicators. OBJECTIVE: Our objective was to determine how UM participants compared with women in the Australian population at large on a variety of health indicators...
January 10, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29319720/depression-and-adherence-to-antiretroviral-treatment-in-hiv-positive-men-in-s%C3%A3-o-paulo-the-largest-city-in-south-america-social-and-psychological-implications
#10
Ricardo Pereira de Moraes, Jorge Casseb
OBJECTIVES: The aim of the present study was to investigate the prevalence of depression and adherence to antiretroviral treatment in two groups of individuals: men who have sex with men (MSM) and men who have sex with women (MSW). METHODS: Two hundred and sixteen participants (MSM=116; MSW=100) who visited the Clinics Hospital of the School of the Medicine of the University of São Paulo completed two independent surveys (the BECK Depression Inventory and an adherence self-declared questionnaire) to evaluate their depression status and adherence to antiretroviral treatment, respectively...
December 2017: Clinics
https://www.readbyqxmd.com/read/29319376/the-effect-of-physical-activity-on-ptsd
#11
Lauren M Oppizzi, Reba Umberger
Although physical activity (PA) is known to reduce anxiety and depression, less is known about the effects of PA on post-traumatic stress disorder (PTSD). The author examined the state of the science regarding the effect of PA on PTSD. Three themes emerged: PA characteristics, added benefits of PA as a PTSD intervention, and theories on the method of action. Physical activity seems to be an effective adjunct therapy to reduce PTSD symptom severity. Findings are inconsistent between observational and controlled studies...
January 10, 2018: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29317595/hippocampal-metabolic-differences-implicate-distinctions-between-physical-and-psychological-stress-in-four-rat-models-of-depression
#12
Lanxiang Liu, Xinyu Zhou, Yuqing Zhang, Juncai Pu, Lining Yang, Shuai Yuan, Libo Zhao, Chanjun Zhou, Hanping Zhang, Peng Xie
Major depressive disorder (MDD) is a heterogeneous and multi-factorial disorder, and the underlying molecular mechanisms remain largely unknown. However, many studies have indicated that the molecular mechanisms underlying depression in response to different stress may differ. After screening, 28-30 rats were included in each model of depression (chronic unpredictable mild stress (CUMS); learned helplessness (LH); chronic restraint stress (CRS); or social defeat (SD)). Non-targeted gas chromatography-mass spectrometry was used to profile the metabolic changes in the hippocampus...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29316519/the-regional-homogeneity-of-cingulate-precuneus-regions-the-putative-biomarker-for-depression-and-anxiety
#13
Chien-Han Lai
OBJECTIVES: In addition to clinical interview, the modern putative biomarker to differentiate depression and anxiety would be warranted. The translational medicine characteristics of neuroimaging, such as the regional homogeneity (ReHo), is an option for depression and anxiety. Therefore we designed this study trying to identify the biomarker pattern for depression and anxiety. METHODS: Resting-state functional magnetic resonance imaging was acquired for 53 patients with first-episode medicine-naïve major depressive disorder (MDD), 53 first-episode medicine-naïve patients with panic disorder (PD) and 54 controls...
January 3, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29310735/what-do-clinical-supervisors-require-to-teach-residents-in-family-medicine-how-to-care-for-seniors
#14
Anik M C Giguere, Paule Lebel, Michèle Morin, Françoise Proust, Charo Rodríguez, Valerie Carnovale, Louise Champagne, France Légaré, Pierre-Hugues Carmichael, Bernard Martineau, Philippe Karazivan, Pierre J Durand
We assessed clinicians' continuing professional development (CPD) needs at family practice teaching clinics in the province of Quebec. Our mixed methodology design comprised an environmental scan of training programs at four family medicine departments, an expert panel to determine priority clinical situations for senior care, a supervisors survey to assess their perceived CPD needs, and interviews to help understand the rationale behind their needs. From the environmental scan, the expert panel selected 13 priority situations...
January 9, 2018: Canadian Journal on Aging, la Revue Canadienne du Vieillissement
https://www.readbyqxmd.com/read/29306938/overview-of-systematic-reviews-of-mindfulness-meditation-based-interventions-for-people-with-long-term-conditions
#15
Jaqui Long, Michelle Briggs, Felicity Astin
Context • Increasing numbers of people worldwide live with a long-term health condition (LTC). Finding new ways to support people diagnosed with LTCs is important, both to improve their health-related quality of life and to manage the demands on health services that their conditions present. This effort includes a recognition of the importance of interventions to promote self-care. A growing number of systematic reviews of mindfulness meditation-based interventions (MMIs) for people with LTCs have been published but are diverse in scope and quality...
October 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/29305720/barriers-for-the-implementation-of-guidelines-in-palliative-care-results-from-a-national-survey-of-professionals
#16
Helen Kalies, Rieke Schöttmer, Steffen T Simon, Raymond Voltz, Alexander Crispin, Claudia Bausewein
BACKGROUND: In 2015, an evidence- and consensus-based palliative care guideline in adults with incurable cancer was published by the German Guideline Program. Barriers and enablers for the guideline implementation of members of the German Association for Palliative Medicine (DGP) were unknown. Therefore, the aims of this study were (1) to evaluate professionals' knowledge, motivation, and outcome expectancy towards already existing recommendations for palliative care and (2) to evaluate the self-experienced competence in five medical key topics presented in the new guideline...
January 5, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29303706/fatigue-in-systemic-sclerosis-a-systematic-review
#17
REVIEW
Fabio Basta, Antonella Afeltra, Domenico Paolo Emanuele Margiotta
OBJECTIVES: To systematically review fatigue in systemic sclerosis (SSc) in terms of prevalence, features, correlates, predictors and management. METHODS: We performed a literature search in PubMed (Medline), EBSCO and COCHRANE databases up to June 2017 selecting articles regarding fatigue in SSc. The articles finally selected fulfilled the following eligibility criteria: written in English, referred to fatigue in SSc, reporting original data, including validated questionnaires measuring fatigue...
December 15, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29298650/potential-application-of-centrifuges-to-protect-the-cns-in-space-and-on-earth
#18
Yoshiki Takamatsu, Gilbert Ho, Yuki Shimizu, Shuei Sugama, Takato Takenouchi, Masaaki Waragai, Jianshe Wei, Makoto Hashimoto
BACKGROUND: Centrifuges are the principal means of generating physiological hypergravity and have been used for many medical purposes, including the therapy of psychiatric diseases and evaluation of vestibular system in the pilots. In particular, modern centrifuges have evolved into mechanically sophisticated precision instruments compared to primitive ones in old times, indicating that centrifuges might possess great potential in modern medicine. Indeed, studies are in progress to apply centrifuges to musculoskeletal degenerative diseases, such as osteoporosis and sarcopenia...
December 29, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29298365/associations-of-prepregnancy-morbid-obesity-and-prenatal-depression-with-gestational-weight-gain
#19
Hema Chagarlamudi, Juhee Kim, Edward Newton
OBJECTIVES: Pregnancy outcomes and infant growth and development are influenced by various prenatal and postnatal factors. Gestational weight gain (GWG) is an important indicator of pregnancy management and outcomes. Information about the interaction between prenatal obesity and depression on GWG among low-income women is limited. There also is a lack of information about morbid obesity and GWG. The purpose of this study was to examine the associations of prepregnancy weight status, including morbid obesity as a separate group, and prenatal depression with GWG using electronic medical records in an academic prenatal clinic serving a largely low-income population...
January 2018: Southern Medical Journal
https://www.readbyqxmd.com/read/29288827/antidepressant-like-effects-of-water-extract-of-gastrodia-elata-blume-on-neurotrophic-regulation-in-a-chronic-social-defeat-stress-model
#20
Yu-En Lin, Shao-Ting Chou, Shih-Hang Lin, Kuan-Hung Lu, Suraphan Panyod, Yi-Syuan Lai, Chi-Tang Ho, Lee-Yan Sheen
ETHNOPHARMACOLOGY RELEVANCE: Gastrodia elata Blume (GE) is a traditional Chinese medicine commonly used to treat dizziness, epilepsy, paralysis and some emotional symptoms in east Asia. We previously showed that the water extract of Gastrodia elata Blume (WGE) possesses anti-depression like effects in a forced swimming test and chronic mild stress model. AIM OF THE STUDY: The aim of this study was to investigate the antidepressant-like effects of WGE and potential mechanisms related to brain-derived neurotrophic factor (BDNF) regulation in mice exposed to chronic social defeat stress (CSDS) model...
December 27, 2017: Journal of Ethnopharmacology
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