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Depression medicine

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https://www.readbyqxmd.com/read/28325221/is-metabolic-dysregulation-associated-with-antidepressant-response-in-depressed-women-in-climacteric-treated-with-individualized-homeopathic-medicines-or-fluoxetine-the-homdep-menop-study
#1
Emma Del Carmen Macías-Cortés, Lidia Llanes-González, Leopoldo Aguilar-Faisal, Juan Asbun-Bojalil
BACKGROUND: Climacteric is associated with both depression and metabolic dysregulation. Scarce evidence suggests that metabolic dysregulation may predict poor response to conventional antidepressants. Response to depression treatment has not been studied in homeopathic medicine. The aim of this study was to investigate the prevalence of metabolic disorders in depressed climacteric women treated with homeopathic medicines, fluoxetine or placebo, and if these alterations have any association with response to depression treatment...
February 2017: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/28323803/patient-response-to-an-integrated-orthotic-and-rehabilitation-initiative-for-traumatic-injuries-the-prioriti-mtf-study
#2
Joseph R Hsu, Johnny G Owens, Jennifer DeSanto, John R Fergason, Kevin M Kuhn, Benjamin K Potter, Daniel J Stinner, Robert G Sheu, Sandra L Waggoner, Jason M Wilken, Yanjie Huang, Daniel O Scharfstein, Ellen J MacKenzie
Although limb salvage is now possible for many high-energy open fractures and crush injuries to the distal tibia, ankle, hindfoot, and midfoot, orthotic options are limited. The Intrepid Dynamic Exoskeletal Orthosis (IDEO) is a custom, energy-storing carbon fiber orthosis developed for trauma patients undergoing limb salvage. The IDEO differs from other orthoses in that it allows patients with ankle weakness to have more normal ankle biomechanics and increased ankle power. This article describes the design of a study to evaluate the effectiveness of the IDEO when delivered together with a high-intensity, sports medicine-based approach to rehabilitation...
April 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28322279/pluripotent-stem-cells-in-neuropsychiatric-disorders
#3
REVIEW
M A Soliman, F Aboharb, N Zeltner, L Studer
Neuropsychiatric disorders place an enormous medical burden on patients across all social and economic ranks. The current understanding of the molecular and cellular causes of neuropsychiatric disease remains limited, which leads to a lack of targeted therapies. Human-induced pluripotent stem cell (iPSC) technology offers a novel platform for modeling the genetic contribution to mental disorders and yields access to patient-specific cells for drug discovery and personalized medicine. Here, we review recent progress in using iPSC technology to model and potentially treat neuropsychiatric disorders by focusing on the most prevalent conditions in psychiatry, including depression, anxiety disorders, bipolar disorder and schizophrenia...
March 21, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28320349/mindfulness-based-interventions-in-epilepsy-a-systematic-review
#4
Karen Wood, Maggie Lawrence, Bhautesh Jani, Robert Simpson, Stewart W Mercer
BACKGROUND: Mindfulness based interventions (MBIs) are increasingly used to help patients cope with physical and mental long-term conditions (LTCs). Epilepsy is associated with a range of mental and physical comorbidities that have a detrimental effect on quality of life (QOL), but it is not clear whether MBIs can help. We systematically reviewed the literature to determine the effectiveness of MBIs in people with epilepsy. METHODS: Medline, Cochrane Central Register of Controlled Trials, EMBASE, CINAHL, Allied and Complimentary Medicine Database, and PsychInfo were searched in March 2016...
March 20, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28319909/stability-and-change-in-disease-prestige-a-comparative-analysis-of-three-surveys-spanning-a-quarter-of-a-century
#5
Dag Album, Lars E F Johannessen, Erik B Rasmussen
In this paper, we present a comparative analysis of three survey studies of disease prestige in medical culture. The studies were conducted in 1990, 2002 and 2014 using the same research design. In each of the three rounds, a sample of Norwegian physicians was asked to rate a set of 38 diseases on a scale from 1 to 9 according to the prestige they believed health personnel in general would award them. The results show a remarkable stability in the prestige rank order over 25 years. The top three diseases in all three surveys were leukaemia, brain tumour and myocardial infarction...
March 14, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28319167/association-between-internet-addiction-and-depression-in-thai-medical-students-at-faculty-of-medicine-ramathibodi-hospital
#6
Thummaporn Boonvisudhi, Sanchai Kuladee
OBJECTIVE: To study the extent of Internet addiction (IA) and its association with depression in Thai medical students. METHODS: A cross-sectional study was conducted at Faculty of Medicine, Ramathibodi Hospital. Participants were first- to fifth-year medical students who agreed to participate in this study. Demographic characteristics and stress-related factors were derived from self-rated questionnaires. Depression was assessed using the Thai version of Patient Health Questionnaire (PHQ-9)...
2017: PloS One
https://www.readbyqxmd.com/read/28318462/the-epidemiology-of-operation-stress-during-continuing-promise-2011-a-humanitarian-response-and-disaster-relief-mission-aboard-a-us-navy-hospital-ship
#7
William T Scouten, Melissa L Mehalick, Elizabeth Yoder, Andrea McCoy, Tracy Brannock, Mark S Riddle
Introduction Operational stress describes individual behavior in response to the occupational demands and tempo of a mission. The stress response of military personnel involved in combat and peace-keeping missions has been well-described. The spectrum of effect on medical professionals and support staff providing humanitarian assistance, however, is less well delineated. Research to date concentrates mainly on shore-based humanitarian missions. Problem The goal of the current study was to document the pattern of operational stress, describe factors responsible for it, and the extent to which these factors impact job performance in military and civilian participants of Continuing Promise 2011 (CP11), a ship-based humanitarian medical mission...
March 20, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28316177/-efficacy-and-safety-of-tertiary-hospital-guided-and-community-driven-family-self-help-cardiac-rehabilitation-model
#8
R J Ding, L M Gao, L Chu, W L Xie, X R Wang, Q Tang, H L Wang, D Y Hu
Objective: To explore the efficacy and safety of tertiary hospital guided and community-driven family self-help cardiac rehabilitation model. Methods: This study was a prospective randomized controlled study, 80 patients from Beijing Electrical Power Hospital and Beijing Jingmei Group General Hospital with acute coronary syndrome were included from June to December 2015 and divided into 2 groups. Patients in rehabilitation group (n=52) received tertiary hospital(Peiking University Peoples' Hospital) guided and community-driven family self-help cardiac rehabilitation for 3 months, and patients in control group (n=28) received routine secondary treatment for 3 months...
March 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28315478/improving-palliative-care-trough-teamwork-impactt-in-nursing-homes-study-design-and-baseline-findings
#9
Helena Temkin-Greener, Susan Ladwig, Zhiqiu Ye, Sally A Norton, Dana B Mukamel
BACKGROUND: The 2014 Institute of Medicine report recommended that healthcare providers caring for individuals with advanced illness have basic palliative care competencies in communication, inter-professional collaboration, and symptom management. Nursing homes, where one in three American decedents live and die, have fallen short of these competency goals. We implemented an intervention study to examine the efficacy of nursing home-based integrated palliative care teams in improving the quality of care processes and outcomes for residents at the end of life...
March 14, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28303466/do-statins-have-antidepressant-effects
#10
Ole Köhler-Forsberg, Christiane Gasse, Michael Berk, Søren Dinesen Østergaard
Statins are used widely in primary and secondary prevention of cardiovascular disease; a treatment effect that has long been thought to be due to their cholesterol-lowering properties. However, statins also have a wide range of anti-inflammatory effects independent of their lipid-lowering mechanisms. In depression, low-grade inflammation is a replicated finding, and several studies have shown antidepressant properties of diverse anti-inflammatory drugs. Large observational studies have suggested reduced risks of depression amongst those taking statins, an effect that is thought to be explained by the anti-inflammatory properties of this class of drugs...
March 16, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28295616/associations-between-anesthetic-variables-and-functional-outcome-in-dogs-with-thoracolumbar-intervertebral-disk-extrusion-undergoing-decompressive-hemilaminectomy
#11
J Fenn, E Laber, K Williams, C A Rousse, P J Early, C L Mariani, K R Muñana, S De Decker, H A Volk, N J Olby
BACKGROUND: Outcome of acute experimental spinal cord injury is strongly associated with tissue perfusion and oxygenation. Cardiopulmonary depression could affect outcome in dogs undergoing general anesthesia for surgical treatment of thoracolumbar intervertebral disk extrusion (IVDE). HYPOTHESIS/OBJECTIVES: To evaluate the effects of general anesthesia on functional outcome in dogs undergoing surgery to treat thoracolumbar IVDE. ANIMALS: Eighty-four client-owned dogs with acute thoracolumbar IVDE treated by decompressive hemilaminectomy...
March 13, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28293046/efficacy-of-risperidone-augmentation-with-ondansetron-in-the-treatment-of-negative-and-depressive-symptoms-in-schizophrenia-a-randomized-clinical-trial
#12
Roya Samadi, Susan Soluti, Reza Daneshmand, Shervin Assari, Ali Akhoundpour Manteghi
BACKGROUND: Given the potential role of the 5-hydroxytryptamine-3 receptor in the pathogenesis of schizophrenia, this study was performed to determine whether ondansetron plus risperidone could reduce the negative and depressive symptoms in patients with treatment-resistant schizophrenia. METHODS: In a double-blinded, placebo-controlled, randomized trial (IRCT registration # 201112125280N7), in 2012-2013 in Mashhad, Iran, 38 patients with treatment-resistant schizophrenia received risperidone either combined with a fixed dose (4-8 mg/d) of ondansetron (n=18) or with a placebo (n=20) for 12 weeks...
January 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28289468/the-effect-of-an-educational-intervention-in-family-phisicians-on-self-rated-quality-of-life-in-patients-with-medically-unexplained-symptoms
#13
Vojislav Ivetić, Klemen Pašić, Polona Selič
INTRODUCTION: Medically unexplained symptoms (MUS) are very common in family medicine, despite being a poorly-defined clinical entity. This study aimed to evaluate the effect of an educational intervention (EI) on self-rated quality of life, treatment satisfaction, and the family physician-patient relationship in patients with MUS. METHODS: In a multi-centre longitudinal intervention study, which was performed between 2012 and 2014, patients were asked to rate their quality of life, assess their depression, anxiety, stress and somatisation, complete the Hypochondriasis Index, the Medical Interview Satisfaction Scale and the Patient Enablement Instrument for assessing the physician-patient relationship, before and after the EI...
June 1, 2017: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/28288330/the-pharmacodynamic-active-components-study-of-tibetan-medicine-gentianopsis-paludosa-on-ulcerative-colitis-fibrosis
#14
Nian-Hua Lu, Hui-Qiao Zhao, Ming Jing, Xiong Liu, Chun-Zhen Ren, Xue-Feng Liu, Juan-Juan Liu, Yan-Xia Zhang
The current study focused on the pharmacodynamic activity components of Gentianopsis paludosa against ulcerative colitis (UC) fibrosis including symptoms of intestinal diarrhea and inflammatory. Trinitro-benzene-sulfonic acid induced UC model rats were gavaged with gradient polarity extracts respectively from ethanol-extract of Gentianopsis paludosa. Masson staining and qRT-PCR methods were respectively used to assess the degree of UC fibrosis and detect the mRNA expressions of collagen I, collagen III, a-smooth muscle actin (α-SMA) and E-cadherin in colon tissue...
March 10, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28287625/a-novel-strategy-for-clustering-major-depression-individuals-using-whole-genome-sequencing-variant-data
#15
Chenglong Yu, Bernhard T Baune, Julio Licinio, Ma-Li Wong
Major depressive disorder (MDD) is highly prevalent, resulting in an exceedingly high disease burden. The identification of generic risk factors could lead to advance prevention and therapeutics. Current approaches examine genotyping data to identify specific variations between cases and controls. Compared to genotyping, whole-genome sequencing (WGS) allows for the detection of private mutations. In this proof-of-concept study, we establish a conceptually novel computational approach that clusters subjects based on the entirety of their WGS...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28286776/the-efficacy-of-acupuncture-for-treating-depression-related-insomnia-compared-with-a-control-group-a-systematic-review-and-meta-analysis
#16
REVIEW
Bo Dong, Zeqin Chen, Xuan Yin, Danting Li, Jie Ma, Ping Yin, Yan Cao, Lixing Lao, Shifen Xu
Objective. To evaluate the effectiveness of acupuncture as monotherapy and as an alternative therapy in treating depression-related insomnia. Data Source. Seven databases were searched starting from 1946 to March 30, 2016. Study Eligibility Criteria. Randomized-controlled trials of adult subjects (18-75 y) who had depression-related insomnia and had received acupuncture. Results. 18 randomized-controlled clinical trials (RCTs) were introduced in this meta-analysis. The findings determined that the acupuncture treatment made significant improvements in PSQI score (MD = -2...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28274800/a-screening-tool-to-detect-clinical-manganese-neurotoxicity
#17
Brad A Racette, Anat Gross, Susan R Criswell, Harvey Checkoway, Susan Searles Nielsen
Manganese (Mn) over-exposure in occupational settings is associated with basal ganglia toxicity and a movement disorder characterized by parkinsonism (i.e., the signs and symptoms of Parkinson disease). A simple test to help non-neurologists identify workers with clinical Mn neurotoxicity represents an unmet need. In a cohort of Mn-exposed workers from welding worksites, with extensive clinical data, we developed a linear regression model to predict the Unified Parkinson Disease Rating Scale motor subsection part 3 (UPDRS3) score...
March 5, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28274132/outcomes-of-music-therapy-interventions-on-symptom-management-in-palliative-medicine-patients
#18
Lisa M Gallagher, Ruth Lagman, Lisa Rybicki
PURPOSE: Evidence has demonstrated the positive effects of music therapy on symptom management for palliative medicine patients. Previous studies have addressed patient needs, with limited discussion involving the relationship between interventions utilized to improve symptoms. The purpose of this study was to understand the impact of music therapy sessions; identify common music therapy goals and interventions and assess their effect; and investigate the effects of gender, age, and type of cancer on symptoms in patients who experienced music therapy...
January 1, 2017: American Journal of Hospice & Palliative Care
https://www.readbyqxmd.com/read/28273961/role-of-glutathione-s-transferase-in-coronary-artery-disease-patients-with-and-without-type-2-diabetes-mellitus
#19
Sheetal Pahwa, Ritu Sharma, Balwant Singh
INTRODUCTION: Glutathione S - transferase (GST) is an important enzyme in detoxification and helps in lowering oxidative stress. It is speculated that this enzyme is induced under conditions of oxidative stress as a protective mechanism. AIM: To evaluate the status of Glutathione S-transferase in Coronary artery disease patients with and without type 2 Diabetes mellitus. MATERIALS AND METHODS: The study was conducted in the Department of Biotechnology, Swami Satyanand College of Management and Technology in collaboration with Department of Biochemistry, Govt Medical College Amritsar...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28273884/2d-qsar-and-3d-qsar-comsia-studies-on-a-series-of-r-2-2-1h-indol-2-yl-ethyl-amino-1-phenylethan-1-ol-with-human-%C3%AE-%C3%A2-adrenergic-activity
#20
Gastón Apablaza, Luisa Montoya, Cesar Morales-Verdejo, Marco Mellado, Mauricio Cuellar, Carlos F Lagos, Jorge Soto-Delgado, Hery Chung, Carlos David Pessoa-Mahana, Jaime Mella
The β₃ adrenergic receptor is raising as an important drug target for the treatment of pathologies such as diabetes, obesity, depression, and cardiac diseases among others. Several attempts to obtain selective and high affinity ligands have been made. Currently, Mirabegron is the only available drug on the market that targets this receptor approved for the treatment of overactive bladder. However, the FDA (Food and Drug Administration) in USA and the MHRA (Medicines and Healthcare products Regulatory Agency) in UK have made reports of potentially life-threatening side effects associated with the administration of Mirabegron, casting doubts on the continuity of this compound...
March 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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