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Mood stablizer

Pavo Filaković, Anamarija Petek Erić
The psychopathological dynamics in suicidality overcomes actual diagnostic distribution therefore pharmacotherapy has restricted role in overall prevention of suicidal behaviour among mentally ill and is demanding for clinician. This role is achieved through reduction and alleviation of suicidal risk with rational and individual pharmacotherapeutic approach emphasising effective, safe and tolerable treatment. The genetic and epigenetic factors, dysfunction of neurotransmitter, neuroendocrine system and stress response system has been determining for neurobiology of suicidality...
September 2013: Collegium Antropologicum
Bo Xing, Yan Zhao, Hui Zhang, Yonghui Dang, Teng Chen, Jingfeng Huang, Qi Luo
Valproic acid (VPA), widely used as mood stablizer, has been shown therapeutic effects in controlling both episodes of mania and depression. The neurobiological actions by which valproic acid exerts these effects have not been established. Ventrolateral orbital cortex (VLO) is a subregion of orbitofrontal cortex (OFC) that has been closely associated with depression. However, there are few studies aimed at investigating the role of the VLO in the neurobiology of depression. In the present study, we investigated the effects on rat forced swimming test (FST) of microinjected VPA into the VLO...
May 30, 2011: Brain Research Bulletin
E Vieta, M Reinares, B Corbella, A Benabarre, I Gilaberte, F Colom, A Martínez-Arán, C Gastó, M Tohen
The aim of this study was to estimate the long-term effectiveness of olanzapine as adjunctive therapy in patients with bipolar disorder who exhibited an inadequate response to mood stabilizers. Twenty-three Research Diagnostic Criteria (RDC) patients with bipolar I and II were assessed by means of the Schedule for Affective Disorders and Schizophrenia and entered if they gave their consent to participate. All of them had experienced frequent relapses, residual subsyndromal symptoms, and inadequate responses to other drugs, such as lithium, valproate, or carbamazepine...
October 2001: Journal of Clinical Psychopharmacology
C Y Chen, C Y Liu, Y Y Yang
The aim of this study was to investigate the relationship between panic attacks and hostility in patients with chronic schizophrenia. Thirty-two patients with a minimum 2-year history of treatment for schizophrenia were interviewed. The patients took mood stablizers lithium, carbamazepine and valproate adjunctively for hostility and anger attacks. Panic attacks were defined by Structure Clinical Interview of DSM-IV. Severity of psychopathology was assessed by the Hamilton Depression Rating Scale (HDRS) and Brief Psychiatric Rating Scale (BPRS)...
August 2001: Psychiatry and Clinical Neurosciences
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