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MiRNA ezh2

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https://www.readbyqxmd.com/read/27895750/microrna-298-inhibits-malignant-phenotypes-of-epithelial-ovarian-cancer-by-regulating-the-expression-of-ezh2
#1
Fenmei Zhou, Juan Chen, Hairong Wang
MicroRNA (miRNA or miR)-298 has been reported to be downregulated and to modify the expression of the polycomb protein enhancer of zeste 2 (EZH2) in recurrent epithelial ovarian cancer (EOC). To date, no functional evidence of a miR-298-EZH2 axis in EOC has been documented. The present study aimed to investigate the associations of miR-298 and/or EZH2 expression with clinicopathological features of EOC patients, and revealed their roles in cell motility based on EOC cell lines. Reverse transcription-quantitative polymerase chain reaction was performed to detect the expression levels of miR-298 and EZH2 messenger RNA in human EOC tissues and cell lines...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27890434/mir-98-inhibits-hepatocellular-carcinoma-cell-proliferation-via-targeting-ezh2-and-suppressing-wnt-%C3%AE-catenin-signaling-pathway
#2
Jun-Jie Zhang, Jiang-Tao Chen, Long Hua, Kun-Hou Yao, Chen-Yu Wang
Hepatocellular carcinoma (HCC) is a highly aggressive solid malignancy in the word. Aberrant microRNA (miRNA) expression is involved in human diseases including cancer. In the current study, we explore the function of miR-98 in HCC cell proliferation. We found that expression level of miR-98 was significantly decreased in HCC tissues and cells lines compared with adjacent non-tumor issues and human hepatic cell line LO2. Increased expression of miR-98 suppressed HCC cell proliferation and arrested HCC cell cycle in G0/G1 phase...
November 24, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27845386/mir-101-targets-the-ezh2-wnt-%C3%AE-catenin-the-pathway-to-promote-the-osteogenic-differentiation-of-human-bone-marrow-derived-mesenchymal-stem-cells
#3
Hongrui Wang, Yake Meng, Quanjun Cui, Fujun Qin, Haisong Yang, Yu Chen, Yajun Cheng, Jiangang Shi, Yongfei Guo
Mounting evidence indicates that microRNAs (miRNAs) are involved in multiple processes of osteogenic differentiation. MicroRNA-101 (miR-101), identified as a tumor suppressor, has been implicated in the pathogenesis of several types of cancer. However, the expression of miR-101 and its roles in the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) remain unclear. We found that the miR-101 expression level was significantly increased during the osteogenic differentiation of hBMSCs...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27831649/mir-129-5p-is-downregulated-in-breast-cancer-cells-partly-due-to-promoter-h3k27m3-modification-and-regulates-epithelial-mesenchymal-transition-and-multi-drug-resistance
#4
Q-X Luan, B-G Zhang, X-J Li, M-Y Guo
OBJECTIVE: In this study, we firstly studied whether H3K27me3 modification is a mechanism of miR-129-5p downregulation in breast cancer and further investigated the functional role of miR-129-5p in epithelial-to-mesenchymal transition (EMT) and in multi-drug resistance (MDR) of the cancer cells. MATERIALS AND METHODS: Immunoprecipitation (IP) and Chromatin Immunoprecipitation (ChIP) assay were performed to detect the association among SOX4, EZH2 and H3K27me3 and their enrichment in the promoter region of miR-129-2...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27823969/targeting-ezh1-and-ezh2-contributes-to-the-suppression-of-fibrosis-associated-genes-by-mir-214-3p-in-cardiac-myofibroblasts
#5
Wen-Si Zhu, Chun-Mei Tang, Zhen Xiao, Jie-Ning Zhu, Qiu-Xiong Lin, Yong-Heng Fu, Zhi-Qin Hu, Zhuo Zhang, Min Yang, Xi-Long Zheng, Shu-Lin Wu, Zhi-Xin Shan
The role of microRNA-214-3p (miR-214-3p) in cardiac fibrosis was not well illustrated. The present study aimed to investigate the expression and potential target of miR-214-3p in angiotensin II (Ang-II)-induced cardiac fibrosis. MiR-214-3p was markedly decreased in the fibrotic myocardium of a mouse Ang-II infusion model, but was upregulated in Ang-II-treated mouse myofibroblasts. Cardiac fibrosis was shown attenuated in Ang-II-infused mice received tail vein injection of miR-214-3p agomir. Consistently, miR-214-3p inhibited the expression of Col1a1 and Col3a1 in mouse myofibroblasts in vitro...
November 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27705913/epithelioid-peritoneal-mesothelioma-a-hybrid-phenotype-within-a-mesenchymal-epithelial-epithelial-mesenchymal-transition-framework
#6
Fabio Bozzi, Silvia Brich, Gian Paolo Dagrada, Tiziana Negri, Elena Conca, Barbara Cortelazzi, Antonino Belfiore, Federica Perrone, Ambra Vittoria Gualeni, Annunziata Gloghini, Antonello Cabras, Monica Brenca, Roberta Maestro, Nadia Zaffaroni, Paolo Casali, Rossella Bertulli, Marcello Deraco, Silvana Pilotti
The aim of this study was to reconsider the biological characteristics of epithelioid malignant peritoneal mesothelioma (E-MpM) in the light of new concepts about epithelial mesenchymal transition and mesenchymal epithelial reverse transition (EMT/MErT) and the role of epigenetic reprogramming in this context. To this end we profiled surgical specimens and derived cells cultures by a number of complementary approaches i.e. immunohistochemistry, immunofluorescence, in situ hybridization, biochemistry, pluripotent stem cell arrays, treatments with cytokines, growth factors and specific inhibitors...
September 26, 2016: Oncotarget
https://www.readbyqxmd.com/read/27624777/inhibition-of-s-adenosylmethionine-dependent-methyltransferase-attenuates-tgf%C3%AE-1-induced-emt-and-metastasis-in-pancreatic-cancer-putative-roles-of-mir-663a-and-mir-4787-5p
#7
Hardik R Mody, Sau Wai Hung, Mohammad AlSaggar, Jazmine Griffin, Rajgopal Govindarajan
: The identification of epigenetic reversal agents for use in combination chemotherapies to treat human pancreatic ductal adenocarcinomas (PDAC) remains an unmet clinical need. Pharmacologic inhibitors of Enhancer of Zeste Homolog 2 (EZH2) are emerging as potential histone methylation reversal agents for the treatment of various solid tumors and leukemia; however, the surprisingly small set of mRNA targets identified with EZH2 knockdown suggests novel mechanisms contribute to their antitumorigenic effects...
November 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27622325/microrna-126-increases-chemosensitivity-in-drug-resistant-gastric-cancer-cells-by-targeting-ezh2
#8
Ping Wang, Ziqiu Li, Haide Liu, Dongmei Zhou, Aiqin Fu, Enning Zhang
Chemotherapeutic insensitivity is a significant barrier for effective treatment of gastric cancer (GC). Recently, emerging evidence has demonstrated that microRNAs (miRNAs) are critically involved in drug resistance. Here, by a large-scale screen, we noticed low expression of miR-126 in the drug-resistant GC cell lines SGC7901/VCR and SGC7901/ADR compared with their parental cell line SGC7901. Ectopic expression of miR-126 increased sensitivity of SGC7901/VCR and SGC7901/ADR cells to vincristine (VCR) and adriamycin (ADR)...
October 7, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27602159/epigenetic-regulation-of-mirna-124-and-multiple-downstream-targets-is-associated-with-treatment-response-in-myeloid-malignancies
#9
Hongbin Liu, Phillip Pattie, Sahan Chandrasekara, Andrew Spencer, Anthony E Dear
Epigenetic regulation of microRNA (miRNA) expression has recently been implicated in the pathogenesis of myelodysplastic syndrome (MDS). Particular interest has focused on miRNA-124 expression, which is inhibited in MDS and has recently been demonstrated to be upregulated in response to epigenetic treatment (EGT). Previous studies have determined the in vitro and in vivo expression of miRNA-124 and several molecular targets, including cyclin-dependent kinase (CDK) 4, CDK6 and enhancer of zeste homolog 2 (EZH2), in order to elucidate the molecular mechanisms associated with the miRNA-124-mediated therapeutic response to EGT in MDS and identify additional potential biomarkers of early EGT treatment response in myeloid malignancies...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27594424/ezh2-coupled-with-hotair-to-silence-microrna-34a-by-the-induction-of-heterochromatin-formation-in-human-pancreatic-ductal-adenocarcinoma
#10
Chi-Han Li, Zhangang Xiao, Joanna Hung-Man Tong, Ka-Fai To, Xiangdong Fang, Alfred Sl Cheng, Yangchao Chen
MicroRNA-34a (miR-34a) is frequently downregulated in pancreatic ductal adenocarcinoma (PDAC) cells, however, the silencing mechanism remains unclear. Enhancer of zeste homolog 2 (EZH2) is overexpressed in PDAC, and our previous miRNA profiling showed that inhibition of EZH2 in PDAC cells led to the re-expression of a group of tumor suppressor miRNAs including miR-34a. Here, we studied the effect of ectopic EZH2 expression to the silencing of miR-34a, and identified HOTAIR as an interacting partner to induce heterochromatin formation during miR-34a repression...
January 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27562865/mir-26a-and-mir-138-block-the-g1-s-transition-by-targeting-the-cell-cycle-regulating-network-in-prostate-cancer-cells
#11
Kati Erdmann, Knut Kaulke, Christiane Rieger, Karsten Salomo, Manfred P Wirth, Susanne Fuessel
PURPOSE: The tumor-suppressive microRNAs miR-26a and miR-138 are significantly down-regulated in prostate cancer (PCa) and have been identified as direct regulators of enhancer of zeste homolog 2 (EZH2), which is a known oncogene in PCa. In the present study, the influence of miR-26a and miR-138 on EZH2 and cellular function including the impact on the cell cycle regulating network was evaluated in PCa cells. METHODS: PC-3 and DU-145 PCa cells were transfected with 100 nM of miRNA mimics, siRNA against EZH2 (siR-EZH2) or control constructs for 4 h...
November 2016: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27517917/the-antitumor-effect-of-metformin-is-mediated-by-mir-26a-in-breast-cancer
#12
Paula Cabello, Begoña Pineda, Eduardo Tormo, Ana Lluch, Pilar Eroles
Metformin, a drug approved for diabetes type II treatment, has been associated with a reduction in the incidence of breast cancer and metastasis and increased survival in diabetic breast cancer patients. High levels of miR-26a expression have been proposed as one of the possible mechanisms for this effect; likewise, this miRNA has also been associated with survival/apoptosis processes in breast cancer. Our aim was to evaluate if miR-26a and some of its targets could mediate the effect of metformin in breast cancer...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27390862/altered-microrna-expression-is-associated-with-tumor-grade-molecular-background-and-outcome-in-childhood-infratentorial-ependymoma
#13
Magdalena Zakrzewska, Wojciech Fendler, Krzysztof Zakrzewski, Beata Sikorska, Wiesława Grajkowska, Bożenna Dembowska-Bagińska, Iwona Filipek, Łukasz Stefańczyk, Paweł P Liberski
BACKGROUND: Ependymal tumors are the third most common group of brain tumors in children, accounting for about 10% of all primary brain neoplasms. According to the current WHO classification, they comprise four entities with the most frequent ependymoma and anaplastic ependymoma. The most of pediatric tumors are located within the posterior fossa, with a tendency to infiltrate the vital brain structures. This limits surgical resection and poses a considerable clinical problem. Moreover, there are no appropriate outcome prognostic factors besides the extent of surgical resection...
2016: PloS One
https://www.readbyqxmd.com/read/27386402/mir-125b-1-is-repressed-by-histone-modifications-in-breast-cancer-cell-lines
#14
Fernanda Cisneros-Soberanis, Marco A Andonegui, Luis A Herrera
PURPOSE: Downregulation of miR-125b-1 is associated with poor prognosis in breast cancer patients. In this work we investigated the effect of histone modifications on the regulation of this gene promoter. METHODS AND RESULTS: We evaluated the enrichment of two histone modifications involved in gene repression, H3K9me3 and H3K27me3, on the miR-125b-1 promoter in two breast cancer cell lines, MCF7 (luminal A subtype) and MDA-MB-231 (triple-negative subtype), compared to the non-transformed breast cell line MCF10A...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27385092/disruption-of-the-ezh2-mirna-%C3%AE-catenin-signaling-suppresses-aerobic-glycolysis-in-glioma
#15
Yingyi Wang, Min Wang, Wenjin Wei, Dongfeng Han, Xincheng Chen, Qi Hu, Tianfu Yu, Ning Liu, Yongping You, Junxia Zhang
EZH2 is up-regulated in various cancer types, implicating its role in tumorigenesis. Our recent data have shown that repression of EZH2 inhibited glioma growth by inhibition β-catenin signaling. Here, we identified several miRNAs that were repressed by EZH2, which in turn regulate β-catenin expression by its 3'UTR, such as miR-1224-3p, miR-328 and miR-214. Further, EZH2 silenced miR-328 expression by binding to miR-328 promoter and promoting methylation of miR-328 promoter. Finally, miR-328 largely abrogated EZH2 effects on β-catenin expression and glucose metabolism in glioma cells...
July 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27266699/integrated-mirna-and-mrna-expression-profiling-in-fetal-hippocampus-with-down-syndrome
#16
Wei-Li Shi, Zhong-Zhen Liu, Hong-Dan Wang, Dong Wu, Hui Zhang, Hai Xiao, Yan Chu, Qiao-Fang Hou, Shi-Xiu Liao
BACKGROUNDS: Down syndrome (DS), caused by triplication of human chromosome 21, is the most common aneuploidies. The main characteristic of DS patients is intellectual disability. MicroRNAs (miRNAs) play important regulatory roles in various biological processes, such as embryonic development, cell differentiation, proliferation and apoptosis. Several miRNAs have shown association with DS. However, the role of miRNAs in DS patients has not been well elaborated. METHODS: In this research, total RNA extracted from fetal hippocampal tissues was used to analyze miRNA and mRNA expression via Affymetrix miRNA 4...
2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/27229723/difluorinated-curcumin-a-promising-curcumin-analogue-with-improved-anti-tumor-activity-and-pharmacokinetic-profile
#17
REVIEW
Amir Abbas Momtazi, Amirhossein Sahebkar
BACKGROUND: Curcumin, a polyphenol from turmeric, is a dietary phytochemical with a diversity of health benefits including strong anti-tumor effects. Curcumin undergoes a rapid metabolism resulting in a low oral bioavailability. 3, 4-difluorobenzylidene curcumin or (CDF) is a novel fluorinated curcumin analogue which has been shown to be about 3 times more bioavailable than curcumin. This review aimed to summarize the findings of studies related to pharmacokinetic and pharmacological characteristics of CDF...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27150236/micrornas-of-the-mir-290-295-family-maintain-bivalency-in-mouse-embryonic-stem-cells
#18
Bryony Graham, Antoine Marcais, Gopuraja Dharmalingam, Thomas Carroll, Chryssa Kanellopoulou, Johannes Graumann, Tatyana B Nesterova, Anna Bermange, Pijus Brazauskas, Barbara Xella, Skirmantas Kriaucionis, Douglas R Higgs, Neil Brockdorff, Matthias Mann, Amanda G Fisher, Matthias Merkenschlager
Numerous developmentally regulated genes in mouse embryonic stem cells (ESCs) are marked by both active (H3K4me3)- and polycomb group (PcG)-mediated repressive (H3K27me3) histone modifications. This bivalent state is thought to be important for transcriptional poising, but the mechanisms that regulate bivalent genes and the bivalent state remain incompletely understood. Examining the contribution of microRNAs (miRNAs) to the regulation of bivalent genes, we found that the miRNA biogenesis enzyme DICER was required for the binding of the PRC2 core components EZH2 and SUZ12, and for the presence of the PRC2-mediated histone modification H3K27me3 at many bivalent genes...
May 10, 2016: Stem Cell Reports
https://www.readbyqxmd.com/read/27109020/epidrugs-in-the-immunotherapy-of-cutaneous-and-uveal-melanoma
#19
Mario Venza, Maria Visalli, Teresa Catalano, Concetta Beninati, Diana Teti, Isabella Venza
Epigenetic modifications can affect numerous mechanisms used by neoplastic cells to evade immune control. In melanoma epigenetic defects, caused by dysregulations in the expression of genome writers, erasers, or readers, play a significant role in the reduced expression of molecules required for efficient immune recognition as well as antigen presentation and processing. Alterations in gene expression were identified in tumor-associated antigens (TAAs), human leukocyte antigen (HLA) complex, co-stimulatory/accessory molecules, antigen processing machinery (APM), and NKG2D ligands that have been shown to be silenced or down-regulated in melanoma...
April 25, 2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/27102007/expression-of-anril-polycomb-complexes-cdkn2a-b-arf-genes-in-breast-tumors-identification-of-a-two-gene-ezh2-cbx7-signature-with-independent-prognostic-value
#20
Didier Meseure, Sophie Vacher, Kinan Drak Alsibai, Andre Nicolas, Walid Chemlali, Martial Caly, Rosette Lidereau, Eric Pasmant, Celine Callens, Ivan Bieche
UNLABELLED: ANRIL, a long noncoding RNA (lncRNA), has recently been reported to have a direct role in recruiting polycomb repressive complexes PRC2 and PRC1 to regulate the expression of the p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster. Expression analysis of ANRIL, EZH2, SUZ12, EED, JARID2, CBX7, BMI1, p16, p15, and p14/ARF genes was evaluated in a large cohort of invasive breast carcinomas (IBC, n = 456) by qRT-PCR and immunohistochemistry (IHC) was performed on CBX7, EZH2, p14, p15, p16, H3K27me3, and H3K27ac...
July 2016: Molecular Cancer Research: MCR
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