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https://www.readbyqxmd.com/read/28070532/evaluation-of-scd-and-fasn-gene-expression-in-baluchi-iran-black-and-arman-sheep
#1
Salmani Izadi Mohammad, Naserian Abbas Ali, Nasiri Mohammad Reza, Majidzadeh Heravi Reza, Valizadeh Reza
BACKGROUND: With the increasing concern for health and nutrition, dietary fat has attracted considerable attention. The composition of fatty acids in the diet is important because they are associated with major diseases including cancers, diabetes, and cardiovascular disease. The fatty acid synthase (FASN) and stearoyl-CoA desaturase (delta-9-desaturase) (SCD) genes affect fatty acid composition (1). The expression of SCD and FASN genes is related to an increase in conjugated linoleic acid (CLA) in dairy products, which benefits human health...
October 2016: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28061370/fine-particulate-air-pollution-and-premature-ventricular-contractions-the-reasons-for-geographic-and-racial-differences-in-stroke-regards-study
#2
Wesley T O'Neal, Elsayed Z Soliman, Jimmy T Efird, Virginia J Howard, George Howard, Leslie A McClure
BACKGROUND: It is unknown if higher levels of ambient particulate matter (PM) exposure increase the risk for premature ventricular contractions (PVC) in a population-based study of men and women, and if this relationship varies by race or sex. METHODS: We examined the association of PM <2.5µm in diameter (PM2.5) concentration with PVCs in 26,121 (mean age=64±9.3 years; 55% female; 41% black) participants from the REasons for Geographic And Racial Differences in Stroke (REGARDS) study...
January 3, 2017: Environmental Research
https://www.readbyqxmd.com/read/28034564/acute-black-tea-consumption-improves-cutaneous-vascular-function-in-healthy-middle-aged-humans
#3
Kirsty A Woodward, Nicola D Hopkins, Richard Draijer, Young de Graaf, David A Low, Dick H J Thijssen
BACKGROUND & AIMS: Dietary flavonoids, such as those present in black tea, are associated with reduced risk of cardiovascular disease (CVD), possibly through improving nitric oxide (NO) mediated vascular function. The aim of this study was to examine the effect of acute black tea ingestion on cutaneous microvascular function. METHODS: Twenty healthy participants (58 ± 5 y, 9 men) attended two experimental trials (tea, placebo), 7-days apart in a randomised, controlled, double-blind, cross-over design...
December 22, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28029393/urinary-uromodulin-and-risk-of-urinary-tract-infections-the%C3%A2-cardiovascular-health-study
#4
Pranav S Garimella, Traci M Bartz, Joachim H Ix, Michel Chonchol, Michael G Shlipak, Prasad Devarajan, Michael R Bennett, Mark J Sarnak
BACKGROUND: Laboratory studies suggest that urinary uromodulin, the most common protein in the urine of healthy adults, may protect against urinary tract infection (UTI). Epidemiologic studies evaluating this relationship in humans are lacking. STUDY DESIGN: Prospective longitudinal cohort study. SETTING & PARTICIPANTS: 953 participants enrolled in the Cardiovascular Health Study. PREDICTOR: Uromodulin assayed using enzyme-linked immunosorbent assay in spot urine samples...
October 28, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28025462/empagliflozin-and-cardiovascular-outcomes-in-asian-patients-with-type-2-diabetes-and-established-cardiovascular-disease%C3%A3-results-from-empa-reg-outcome-%C3%A2
#5
Kohei Kaku, Jisoo Lee, Michaela Mattheus, Stefan Kaspers, Jyothis George, Hans-Juergen Woerle
BACKGROUND: In the EMPA-REG OUTCOME(®)trial, empagliflozin added to standard of care reduced the risk of 3-point major adverse cardiovascular (CV) events (3-point MACE: composite of CV death, non-fatal myocardial infarction, or non-fatal stroke) by 14%, CV death by 38%, hospitalization for heart failure by 35%, and all-cause mortality by 32% in patients with type 2 diabetes (T2DM) and established CV disease. We investigated the effects of empagliflozin in patients of Asian race.Methods and Results:Patients were randomized to receive empagliflozin 10 mg, empagliflozin 25 mg, or placebo...
December 23, 2016: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28017911/apelin-concentrations-are-associated-with-altered-atherosclerotic-plaque-stability-mediator-levels-and-atherosclerosis-in-rheumatoid-arthritis
#6
Sule Gunter, Ahmed Solomon, Linda Tsang, Angela J Woodiwiss, Chanel Robinson, Aletta M E Millen, Gavin R Norton, Patrick H Dessein
BACKGROUND AND AIMS: Apelin-APJ signaling reduces cardiovascular disease (CVD) risk. In rheumatoid arthritis (RA), the atherosclerosis burden and plaque vulnerability to rupture are increased. We explored relationships between apelin concentrations and subclinical CVD in RA. METHODS: Apelin levels were measured in 235 (114 black, 121 white) RA patients. Associations between apelin concentrations and ultrasound determined carotid artery intima-media thickness (cIMT) and plaque, and levels of matrix metalloproteinase (MMP)-2 and -9 that mediate plaque stability and vulnerability respectively, were identified in confounder adjusted multivariate regression analysis...
November 24, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28009647/relation-of-coagulation-factor-xi-with-incident-coronary-heart-disease-and-stroke-the-cardiovascular-health-study
#7
Duke Appiah, Oluwaseun E Fashanu, Susa R Heckbert, Mary Cushman, Bruce M Psaty, Aaron R Folsom
The role of coagulation factor XI (FXI) in the cause of arterial thrombotic events remains uncertain. We examined the association of FXI with incident coronary heart disease (CHD), ischemic stroke, and hemorrhagic stroke. Data were from 3394 adults (mean age: 74.5 years) enrolled in the Cardiovascular Health Study who had FXI antigen from plasma samples drawn in 1992-1993 and were followed for cardiovascular events until 30 June 2013. Approximately 63% of participants were women and 17% were black. FXI levels were higher in blacks and women, showed positive associations with high-density lipoprotein and total cholesterol, BMI and diabetes, and negative associations with age and alcohol intake...
December 22, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28004063/d-dimer-and-the-risk-of-stroke-and-coronary-heart-disease-the-reasons-for-geographic-and-racial-differences-in-stroke-regards-study
#8
Neil A Zakai, Leslie A McClure, Suzanne E Judd, Brett Kissela, George Howard, Monika Safford, Mary Cushman
D-dimer, a biomarker of coagulation, is higher in blacks than in whites and has been associated with stroke and coronary heart disease (CHD). It was our objective to assess the association of higher D-dimer with stroke and CHD in blacks and whites. REGARDS recruited 30,239 black and white participants across the contiguous US and measured baseline D-dimer in stroke (n=646) and CHD (n=654) cases and a cohort random sample (n=1,104). Cox models adjusting for cardiovascular risk factors determined the hazard ratio (HR) for increasing D-dimer for cardiovascular disease with bootstrapping to assess the difference in HR for CHD versus stroke by race...
December 22, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28002404/epigenome-wide-association-study-of-body-mass-index-and-the-adverse-outcomes-of-adiposity
#9
Simone Wahl, Alexander Drong, Benjamin Lehne, Marie Loh, William R Scott, Sonja Kunze, Pei-Chien Tsai, Janina S Ried, Weihua Zhang, Youwen Yang, Sili Tan, Giovanni Fiorito, Lude Franke, Simonetta Guarrera, Silva Kasela, Jennifer Kriebel, Rebecca C Richmond, Marco Adamo, Uzma Afzal, Mika Ala-Korpela, Benedetta Albetti, Ole Ammerpohl, Jane F Apperley, Marian Beekman, Pier Alberto Bertazzi, S Lucas Black, Christine Blancher, Marc-Jan Bonder, Mario Brosch, Maren Carstensen-Kirberg, Anton J M de Craen, Simon de Lusignan, Abbas Dehghan, Mohamed Elkalaawy, Krista Fischer, Oscar H Franco, Tom R Gaunt, Jochen Hampe, Majid Hashemi, Aaron Isaacs, Andrew Jenkinson, Sujeet Jha, Norihiro Kato, Vittorio Krogh, Michael Laffan, Christa Meisinger, Thomas Meitinger, Zuan Yu Mok, Valeria Motta, Hong Kiat Ng, Zacharoula Nikolakopoulou, Georgios Nteliopoulos, Salvatore Panico, Natalia Pervjakova, Holger Prokisch, Wolfgang Rathmann, Michael Roden, Federica Rota, Michelle Ann Rozario, Johanna K Sandling, Clemens Schafmayer, Katharina Schramm, Reiner Siebert, P Eline Slagboom, Pasi Soininen, Lisette Stolk, Konstantin Strauch, E-Shyong Tai, Letizia Tarantini, Barbara Thorand, Ettje F Tigchelaar, Rosario Tumino, Andre G Uitterlinden, Cornelia van Duijn, Joyce B J van Meurs, Paolo Vineis, Ananda Rajitha Wickremasinghe, Cisca Wijmenga, Tsun-Po Yang, Wei Yuan, Alexandra Zhernakova, Rachel L Batterham, George Davey Smith, Panos Deloukas, Bastiaan T Heijmans, Christian Herder, Albert Hofman, Cecilia M Lindgren, Lili Milani, Pim van der Harst, Annette Peters, Thomas Illig, Caroline L Relton, Melanie Waldenberger, Marjo-Riitta Järvelin, Valentina Bollati, Richie Soong, Tim D Spector, James Scott, Mark I McCarthy, Paul Elliott, Jordana T Bell, Giuseppe Matullo, Christian Gieger, Jaspal S Kooner, Harald Grallert, John C Chambers
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type 2 diabetes, cardiovascular disease and related metabolic and inflammatory disturbances. Although the mechanisms linking adiposity to associated clinical conditions are poorly understood, recent studies suggest that adiposity may influence DNA methylation, a key regulator of gene expression and molecular phenotype. Here we use epigenome-wide association to show that body mass index (BMI; a key measure of adiposity) is associated with widespread changes in DNA methylation (187 genetic loci with P < 1 × 10(-7), range P = 9...
December 21, 2016: Nature
https://www.readbyqxmd.com/read/27998911/life-expectancy-and-cause-specific-mortality-in-type-2-diabetes-a-population-based-cohort-study-quantifying-relationships-in-ethnic-subgroups
#10
Alison K Wright, Evangelos Kontopantelis, Richard Emsley, Iain Buchan, Naveed Sattar, Martin K Rutter, Darren M Ashcroft
OBJECTIVES: This study 1) investigated life expectancy and cause-specific mortality rates associated with type 2 diabetes and 2) quantified these relationships in ethnic subgroups. RESEARCH DESIGN AND METHODS: This was a cohort study using Clinical Practice Research Datalink data from 383 general practices in England with linked hospitalization and mortality records. A total of 187,968 patients with incident type 2 diabetes from 1998 to 2015 were matched to 908,016 control subjects...
December 20, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27993539/the-association-between-hdl-particle-concentration-and-incident-metabolic-syndrome-in-the-multi-ethnic-dallas-heart-study
#11
Preethi Mani, Hao-Yu Ren, Ian J Neeland, Darren K McGuire, Colby R Ayers, Amit Khera, Anand Rohatgi
AIMS: Metabolic syndrome (MetS) increases atherosclerotic cardiovascular disease (ASCVD) risk. Low HDL cholesterol (HDL-C) is a diagnostic criterion of MetS and a major ASCVD risk factor. HDL particle concentration (HDL-P) associates with incident ASCVD independent of HDL-C, but its association with incident MetS has not been studied. We hypothesized that HDL-P would be inversely associated with incident metabolic syndrome independent of HDL-C and markers of adiposity and insulin resistance...
December 12, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27989294/a-comparison-of-black-and-white-racial-differences-in-health-lifestyles-and-cardiovascular-disease
#12
William C Cockerham, Shawn Bauldry, Bryant W Hamby, James M Shikany, Sejong Bae
INTRODUCTION: This study examines the health lifestyles of a cohort of blacks and whites in relation to cardiovascular disease (CVD). The link between health lifestyles and CVD is well established, but most of the focus has been on SES and more research is needed on racial differences. METHODS: Data were from the Coronary Artery Risk Development in Young Adults study of black (n=2,451) and white (n=2,351) men and women. Data were analyzed from baseline examinations in 1985-1986 when the participants were aged 18-30 years and any fatal or nonfatal CVD event that occurred over approximately the next 28 years (until August 2013)...
January 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27984005/treatment-resistant-hypertension-and-outcomes-based-on-randomized-treatment-group-in-allhat
#13
Sripal Bangalore, Barry R Davis, William C Cushman, Sara L Pressel, Paul M Muntner, David A Calhoun, John B Kostis, Paul K Whelton, Jeffrey L Probstfield, Mahboob Rahman, Henry R Black
BACKGROUND: Although hypertension guidelines define treatment resistant hypertension as blood pressure uncontrolled by ≥3 antihypertensive medications, including a diuretic, it is unknown whether patient prognosis differs when a diuretic is included. METHODS: Participants in the Antihypertensive and Lipid-Lowering to Prevent Heart Attack Trial were randomly assigned to first-step therapy with chlorthalidone, amlodipine, or lisinopril. At a Year 2 follow-up visit, those with average BP≥140 mmHg systolic or ≥90 mmHg diastolic on ≥3 antihypertensive medications, or BP<140/90 mmHg on ≥4 antihypertensive medications, were identified as having apparent treatment resistant hypertension...
October 27, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27979836/longitudinal-study-of-cardiometabolic-risk-from-early-adolescence-to-early-adulthood-in-an-ethnically-diverse-cohort
#14
Seeromanie Harding, Maria João Silva, Oarabile R Molaodi, Zinat E Enayat, Aidan Cassidy, Alexis Karamanos, Ursula M Read, J Kennedy Cruickshank
OBJECTIVE: To examine influences of adiposity from early adolescence to early 20s on cardiovascular disease (CVD) risk in the multiethnic Determinants of young Adult Social well-being and Health (DASH) longitudinal study. METHODS: In 2002-2003, 6643 11-13-year-olds from 51 London schools participated at baseline, and 4785 were seen again at 14-16 years. Recently, 665 (97% of invited) participated in pilot follow-up at 21-23 years, with biological and psychosocial measures and blood biomarkers (only at 21-23 years)...
December 14, 2016: BMJ Open
https://www.readbyqxmd.com/read/27977253/reducing-disparities-and-achieving-equity-in-african-american-women-s-health
#15
Faye Z Belgrave, Jasmine A Abrams
The colloquial phrase "Black Don't Crack" refers to perceptions of African American women retaining youthful features over time and seemingly defying the aging process. This conjecture appears to only be skin deep, as across almost every health indicator, African American women fare worse than women in other racial/ethnic groups. African American women experience excess morbidity in obesity, diabetes, and adverse birth outcomes, and are more likely than women of other ethnic groups to die from breast and cervical cancer, cardiovascular disease, and HIV/AIDS...
November 2016: American Psychologist
https://www.readbyqxmd.com/read/27966001/cortisol-brain-derived-neurotrophic-factor-ratio-associated-with-silent-ischaemia-in-a-black-male-cohort-the-sa-bpa-study
#16
Christiaan E Schutte, Leoné Malan, Jacobus D Scheepers, Woudri Oosthuizen, Marike Cockeran, Nicolaas T Malan
AIM: Emotional distress has been associated with cardiovascular disease (CVD) in Africans. Cortisol and brain-derived neurotrophic factor (BDNF), as markers of emotional distress, increase cardiometabolic risk. We therefore aimed to investigate associations between cardiometabolic risk markers and the cortisol-to-BDNF ratio (cortisol:BDNF). METHODS: A cross-sectional study included a bi-ethnic gender cohort (n = 406) aged 44.7 ± 9.52 years. Ambulatory blood pressure (ABPM), ECG, fasting serum cortisol and BDNF levels and cardiometabolic risk markers were obtained...
November 2016: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/27957409/community-health-center-patients-response-to-and-beliefs-about-outreach-promoting-clinical-preventive-services
#17
Tiffany Brown, Ji Young Lee, Timothy Long, Shreya Shah, Thomas Sanchez, Stephen D Persell
We sought community health center (CHC) patients' feedback regarding an outreach intervention promoting primary prevention of cardiovascular disease to patients at increased risk. We performed a telephone survey that assessed whether patients recalled receiving the intervention, what actions occurred in response to the intervention, and patient attitudes regarding receipt of preventive service messages from their CHC. Participants (n = 80) were 89% male, and 59% were black. Among the 88% of respondents who reported a healthcare visit, 84% reported a discussion about cholesterol or heart disease risk with their provider, of these 44% reported a statin was recommended and 89% reported currently taking it...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27941157/association-between-high-sensitivity-troponin-t-and-cardiovascular-risk-in-individuals-with-and-without-metabolic-syndrome-the-aric-study
#18
Yashashwi Pokharel, Wensheng Sun, Dennis T Villareal, Elizabeth Selvin, Salim S Virani, Chiadi E Ndumele, Ron C Hoogeveen, Josef Coresh, Eric Boerwinkle, Kenneth R Butler, Scott D Solomon, James S Pankow, Biykem Bozkurt, Christie M Ballantyne, Vijay Nambi
BACKGROUND: Metabolic syndrome (MetS) is associated with increased risk for cardiovascular disease, but there is heterogeneity in this risk. We evaluated whether high-sensitivity troponin T (hs-cTnT), a marker associated with cardiovascular disease, can stratify risk in MetS. METHODS: We evaluated associations between MetS (and groups with similar number of MetS components) and incident heart failure hospitalization, coronary heart disease, stroke and death using hs-cTnT categories after adjusting for risk factors/markers between 1996 and 2011 in 8204 individuals in the Atherosclerosis Risk In Communities study...
December 9, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27939045/air-pollution-and-cardiovascular-mortality-with-over-25years-follow-up-a-combined-analysis-of-two-british-cohorts
#19
Hakim-Moulay Dehbi, Marta Blangiardo, John Gulliver, Daniela Fecht, Kees de Hoogh, Zaina Al-Kanaani, Therese Tillin, Rebecca Hardy, Nish Chaturvedi, Anna L Hansell
BACKGROUND: Adverse effects of air pollution on cardiovascular disease (CVD) mortality are well established. There are comparatively fewer studies in Europe, and in the UK particularly, than in North America. We examined associations in two British cohorts with >25years of follow-up. METHODS: Annual average NO2, SO2 and black smoke (BS) air pollution exposure estimates for 1991 were obtained from land use regression models using contemporaneous monitoring data...
December 7, 2016: Environment International
https://www.readbyqxmd.com/read/27933186/effect-of-type-and-amount-of-dietary-carbohydrate-on-biomarkers-of-glucose-homeostasis-and-c-reactive-protein-in-overweight-or-obese-adults-results-from-the-omnicarb-trial
#20
Stephen P Juraschek, Edgar R Miller, Elizabeth Selvin, Vincent J Carey, Lawrence J Appel, Robert H Christenson, Frank M Sacks
OBJECTIVE: The glycemic index (GI) of dietary carbohydrate is thought to affect glucose homeostasis. Recently, the Effect of Amount and Type of Dietary Carbohydrates on Risk for Cardiovascular Heart Disease and Diabetes Study (OmniCarb) trial reported that a low-GI diet did not improve insulin sensitivity. We conducted this ancillary study of the OmniCarb trial to determine the effects of GI and carbohydrate content on glucose homeostasis and inflammation. RESEARCH DESIGN AND METHODS: OmniCarb was a randomized cross-over feeding study conducted in overweight or obese adults without diabetes (N=163)...
2016: BMJ Open Diabetes Research & Care
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