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https://www.readbyqxmd.com/read/28739139/results-of-the-hemo-study-suggest-that-p-cresol-sulfate-and-indoxyl-sulfate-are-not-associated-with-cardiovascular-outcomes
#1
Tariq Shafi, Tammy L Sirich, Timothy W Meyer, Thomas H Hostetter, Natalie S Plummer, Seungyoung Hwang, Michal L Melamed, Tanushree Banerjee, Josef Coresh, Neil R Powe
Cardiovascular disease, the leading cause of mortality in hemodialysis patients, is not fully explained by traditional risk factors. To help define non-traditional risk factors, we determined the association of predialysis total p-cresol sulfate, indoxyl sulfate, phenylacetylglutamine, and hippurate with cardiac death, sudden cardiac death, and first cardiovascular event in the 1,273 participants of the HEMO Study. The results were adjusted for potential demographic, clinical, and laboratory confounders. The mean age of the patients was 58 years, 63% were Black and 42% were male...
July 21, 2017: Kidney International
https://www.readbyqxmd.com/read/28736931/genetic-variants-in-hsd17b3-smad3-and-ipo11-impact-circulating-lipids-in-response-to-fenofibrate-in-individuals-with-type-2-diabetes
#2
Daniel M Rotroff, Sonja S Pijut, Skylar W Marvel, John R Jack, Tammy M Havener, Aurora Pujol, Agatha Schluter, Greg A Graf, Henry N Ginsberg, Hetal S Shah, He Gao, Mario-Luca Morieri, Alessandro Doria, Josyf C Mychaleckyi, Howard L McLeod, John B Buse, Michael J Wagner, Alison A Motsinger-Reif
Individuals with type 2 diabetes (T2D) and dyslipidemia are at an increased risk of cardiovascular disease. Fibrates are a class of drugs prescribed to treat dyslipidemia, but variation in response has been observed. To evaluate common and rare genetic variants that impact lipid responses to fenofibrate in statin-treated T2D patients, we examined lipid changes in response to fenofibrate therapy using genome-wide association(GWA). Associations were followed-up using gene expression studies in mice. Common variants in SMAD3 and IPO11 were marginally associated with lipid changes in black subjects(p<5x10(-6) )...
July 24, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28735152/a-systematic-review-of-cardiovascular-emergency-department-visits-hospital-admissions-and-mortality-associated-with-ambient-black-carbon
#3
REVIEW
Thomas J Luben, Jennifer L Nichols, Steven J Dutton, Ellen Kirrane, Elizabeth O Owens, Laura Datko-Williams, Meagan Madden, Jason D Sacks
BACKGROUND: Black carbon (BC) is a ubiquitous component of particulate matter (PM) emitted from combustion-related sources and is associated with a number of health outcomes. OBJECTIVES: We conducted a systematic review to evaluate the potential for cardiovascular morbidity and mortality following exposure to ambient BC, or the related component elemental carbon (EC), in the context of what is already known about the associations between exposure to fine particulate matter (PM2...
July 20, 2017: Environment International
https://www.readbyqxmd.com/read/28726796/three-year-change-in-endothelin-1-and-markers-of-vascular-remodelling-in-a-bi-ethnic-south-african-cohort-the-sabpa-study
#4
C S du Plooy, C M C Mels, H W Huisman, R Kruger
South Africans are at high risk for developing cardiovascular disease. Endothelin-1 is known for its vasoconstrictive properties and its ability to contribute to vascular structural changes. In this study we investigated the association of change in endothelin-1 levels and change in markers implicated in vascular remodelling after 3 years. Serum endothelin-1 levels and markers of vascular remodelling such as carotid intima-media thickness, carotid cross-sectional wall area (CSWA) and arterial compliance were measured...
July 20, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28724650/dynamic-relation-of-changes-in-weight-and-indices-of-fat-distribution-with-cardiac-structure-and-function-the-dallas-heart-study
#5
Bryan Wilner, Sonia Garg, Colby R Ayers, Christopher D Maroules, Roderick McColl, Susan A Matulevicius, James A de Lemos, Mark H Drazner, Ronald Peshock, Ian J Neeland
BACKGROUND: Obesity may increase heart failure risk through cardiac remodeling. Cross-sectional associations between adiposity and cardiac structure and function have been elucidated, but the impact of longitudinal changes in adiposity on cardiac remodeling is less well understood. METHODS AND RESULTS: Participants in the Dallas Heart Study without cardiovascular disease or left ventricular dysfunction underwent assessment of body weight, anthropometrics, and cardiac magnetic resonance imaging at baseline and 7 years later...
July 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28715555/application-of-a-lifestyle-based-tool-to-estimate-premature-cardiovascular-disease-events-in-young-adults-the-coronary-artery-risk-development-in-young-adults-cardia-study
#6
Holly C Gooding, Hongyan Ning, Matthew W Gillman, Christina Shay, Norrina Allen, David C Goff, Donald Lloyd-Jones, Stephanie Chiuve
Importance: Few tools exist for assessing the risk for early atherosclerotic cardiovascular disease (ASCVD) events in young adults. Objective: To assess the performance of the Healthy Heart Score (HHS), a lifestyle-based tool that estimates ASCVD events in older adults, for ASCVD events occurring before 55 years of age. Design, Setting, and Participants: This prospective cohort study included 4893 US adults aged 18 to 30 years from the Coronary Artery Risk Development in Young Adults (CARDIA) study...
July 17, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28715389/extraction-and-purification-of-polyphenols-from-freeze-dried-berry-powder-for-the-treatment-of-vascular-smooth-muscle-cells-in-vitro
#7
Rafaela G Feresin, Shirin Pourafshar, Jingwen Huang, Yitong Zhao, Bahram H Arjmandi, Gloria Salazar
Epidemiological studies indicate that increased flavonoid intake correlates with decreased mortality due to cardiovascular diseases (CVD) in the United States (US) and Europe. Berries are widely consumed in the US and have a high polyphenolic content. Polyphenols have been shown to interact with many molecular targets and to exert numerous positive biological functions, including antioxidant, anti-inflammatory, and cardioprotective effects. Polyphenols isolated from blackberry (BL), raspberry (RB), and black raspberry (BRB) reduce oxidative stress and cellular senescence in response to angiotensin II (Ang II)...
July 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28713383/the-toxicological-mechanisms-of-environmental-soot-black-carbon-and-carbon-black-focus-on-oxidative-stress-and-inflammatory-pathways
#8
REVIEW
Rituraj Niranjan, Ashwani Kumar Thakur
The environmental soot and carbon blacks (CBs) cause many diseases in humans, but their underlying mechanisms of toxicity are still poorly understood. Both are formed after the incomplete combustion of hydrocarbons but differ in their constituents and percent carbon contents. For the first time, "Sir Percival Pott" described soot as a carcinogen, which was subsequently confirmed by many others. The existing data suggest three main types of diseases due to soot and CB exposures: cancer, respiratory diseases, and cardiovascular dysfunctions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28708433/physical-health-outcomes-in-preschoolers-with-prior-authorization-for-antipsychotics
#9
Yu-Jung Wei, Xinyue Liu, Nikhil Rao, Marie McPherson, Mary Beth Jones, Regina Bussing, Almut G Winterstein
OBJECTIVE: To examine incidence of adverse health outcomes and associated factors among preschoolers (under age 6) who received antipsychotic treatment through the Florida Medicaid Prior Authorization (PA) program. METHODS: Using Florida's PA registry linked to the state's Medicaid claims data, we ascertained incident outcomes during PA-approved antipsychotic use between April 2008 and September 2015 (7.5 years). Six outcomes associated with use of antipsychotics included: diabetes, obesity, hyperlipidemia, hyperprolactinemia, cardiovascular disease (CVD) (including hypertension, ventricular arrhythmia, and other CVDs), and extrapyramidal symptoms (EPS) (including dystonia, akathisia, parkinsonism, and tardive dyskinesia)...
July 14, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28698270/association-between-endothelin-1-levels-and-kidney-disease-among-blacks
#10
Casey M Rebholz, Jane L Harman, Morgan E Grams, Adolfo Correa, Daichi Shimbo, Josef Coresh, Bessie A Young
Endothelin-1, a marker of endothelial dysfunction, is a potent vasoconstrictor released by endothelial cells and an important regulator of renal physiology. It is not known whether elevated serum levels of endothelin-1 indicate future risk of kidney disease in the general population. In participants in the Jackson Heart Study, a community-based observational study of cardiovascular risk in black adults, we measured serum endothelin-1 level at baseline (2000-2004; n=3538). We defined incident CKD as eGFR<60 ml/min per 1...
July 11, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28698190/predicted-atherosclerotic-cardiovascular-disease-risk-and-masked-hypertension-among-blacks-in-the-jackson-heart-study
#11
D Edmund Anstey, John N Booth, Marwah Abdalla, Tanya M Spruill, Yuan-I Min, Paul Muntner, Daichi Shimbo
BACKGROUND: Among individuals without hypertension based on clinic blood pressure (BP), it is unclear who should be screened for masked hypertension, defined as having hypertension based on out-of-clinic BP. We hypothesized that individuals with a higher 10-year predicted atherosclerotic cardiovascular disease (ASCVD) risk, calculated using the pooled cohort risk equations, have a higher prevalence of masked hypertension. METHODS AND RESULTS: We analyzed data from the Jackson Heart Study-a population-based cohort of blacks-to determine the association of predicted ASCVD risk with masked hypertension...
July 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28697037/the-association-of-surgical-versus-natural-menopause-with-future-left-ventricular-structure-and-function-the-coronary-artery-risk-development-in-young-adults-cardia-study
#12
Duke Appiah, Pamela J Schreiner, Chike C Nwabuo, Melissa F Wellons, Cora E Lewis, Joao A Lima
OBJECTIVE: To evaluate the association between surgical menopause (SM) versus natural menopause (NM) in relation to later left ventricular (LV) structure and function, while taking into account the LV parameters and other cardiovascular disease risk factor (CVDRF) levels that predate the menopausal transition. METHODS: We studied 825 premenopausal women from the Coronary Artery Risk Development in Young Adults study in 1990 to 1991 (baseline, mean age 32 years) who later reached menopause by 2010 to 2011 and had echocardiograms at these two time points...
July 10, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28696578/does-education-modify-the-effect-of-ethnicity-in-the-expression-of-ideal-cardiovascular-health-the-baptist-health-south-florida-employee-study
#13
Oluseye Ogunmoroti, Ovie A Utuama, Erin D Michos, Javier Valero-Elizondo, Victor Okunrintemi, Ziyad Ben Taleb, Raed Bahelah, Sankalp Das, Maribeth Rouseff, Don Parris, Arthur Agatston, Theodore Feldman, Emir Veledar, Wasim Maziak, Khurram Nasir
BACKGROUND: Despite the progress made to decrease risk factors for cardiovascular diseases, disparities still exist. We examined how education and ethnicity interact to determine disparities in cardiovascular health (CVH) as defined by the American Heart Association. HYPOTHESIS: Education modifies the effect of ethnicity on CVH. METHODS: Individual CVH metrics (smoking, physical activity, body mass index, diet, total cholesterol, blood pressure, and blood glucose) were defined as ideal, intermediate, or poor...
July 11, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28696265/black-white-differences-in-incident-fatal-nonfatal-and-total-coronary-heart-disease
#14
Lisandro D Colantonio, Christopher M Gamboa, Joshua S Richman, Emily B Levitan, Elsayed Z Soliman, George Howard, Monika M Safford
BACKGROUND: Blacks have higher coronary heart disease (CHD) mortality compared with whites. However, a previous study suggests that nonfatal CHD risk may be lower for black versus white men. METHODS: We compared fatal and nonfatal CHD incidence and CHD case-fatality among blacks and whites in the Atherosclerosis Risk in Communities study (ARIC), the Cardiovascular Health Study (CHS), and the Reasons for Geographic and Racial Differences in Stroke study (REGARDS) by sex...
July 11, 2017: Circulation
https://www.readbyqxmd.com/read/28692446/ethnicity-and-arterial-stiffness-in-children-and-adolescents-from-a-brazilian-population
#15
Divanei Zaniqueli, Rafael O Alvim, Sara G Luiz, Polyana R Oliosa, Roberto de Sá Cunha, José G Mill
BACKGROUND: Increased stiffness of large arteries is an important determinant of cardiovascular disease risk. Higher values of arterial stiffness measured by carotid-femoral pulse wave velocity (cf-PWV) have been measured in adult African-Americans compared with whites. Studies assessing ethnic differences in cf-PWV among children and adolescents are scarce. This study sought to evaluate the association between ethnicity and cf-PWV in Brazilian children and adolescents. METHODS: Seven hundred and seventy-one children and adolescents (211 blacks and 560 nonblacks, 11...
July 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28691730/effects-of-colocynth-alkaloids-and-glycosides-on-wistar-rats-fed-high-fat-diet-a-biochemical-and-morphological-study
#16
Zahia Birem, Khadidja Tabani, Farid Lahfa, Rabah Djaziri, Fatima Hadjbekkouche, Elhadj Ahmed Koceir, Naima Omari
INTRODUCTION: . In traditional medicine, Citrullus colocynthis is used to treat diabetes, hyperlipidemia, cardiovascular diseases, inflammation, and oxidative stress, all of which can appear when a diet rich in vegetable fats, such as palm oil, is continuously consumed. Such high-fat diets are chronic stressors of the hypothalamic-pituitary-adrenal axis. The objective of our study was to analyze and evaluate the effects of colocynth total alkaloids and glycosides on metabolic, hormonal, and structural disorders of the adrenal medulla in Wistar rats fed a high-fat diet...
July 10, 2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28689339/longitudinal-impact-of-a-park-based-afterschool-healthy-weight-program-on-modifiable-cardiovascular-disease-risk-factors-in-youth
#17
Sarah E Messiah, Emily M D'Agostino, Eric Hansen, M Sunil Mathew, Deidre Okeke, Maria Nardi, Jack Kardys, Kristopher L Arheart
Community-based programs hold significant potential to prevent cardiovascular disease (CVD) risk in youth. We describe here the longitudinal change in several modifiable CVD risk factors after participation in up to 3 years of Fit2Play™, a park-based afterschool program. Children ages 6-15 years old (N = 2261, mean age 9.0 years, 50% Hispanic, 47% non-Hispanic black, 54% male) who participated in Fit2Play™ for either 1-3 school years between 2010 and 2016 had height, weight, 4-site skinfold thicknesses, systolic and diastolic blood pressure, the progressive aerobic cardiovascular endurance run test, and health/wellness knowledge and behavior scores collected at the beginning and end of the school year(s)...
July 8, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28678202/associations-of-pm2-5-and-black-carbon-with-hospital-emergency-room-visits-during-heavy-haze-events-a-case-study-in-beijing-china
#18
Fengchao Liang, Lin Tian, Qun Guo, Dane Westerdahl, Yang Liu, Xiaobin Jin, Guoxing Li, Xiaochuan Pan
In January 2013, severe haze events over northeastern China sparked substantial health concerns. This study explores the associations of fine particulate matter less than 2.5 μm (PM2.5) and black carbon (BC) with hospital emergency room visits (ERVs) during a haze season in Beijing. During that period, daily counts of ERVs for respiratory, cardiovascular and ocular diseases were obtained from a Level-3A hospital in Beijing from 1 December 2012 to 28 February 2013, and associations of which with PM2.5 and BC were estimated by time-stratified case-crossover analysis in single- and two-pollutant models...
July 5, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28676520/transcription-factor-runx1-regulates-platelet-pctp-phosphatidylcholine-transfer-protein-implications-for-cardiovascular-events
#19
Guangfen Mao, Natthapol Songdej, Deepak Voora, Lawrence E Goldfinger, Fabiola E Del Carpio-Cano, Rachel A Myers, A Koneti Rao
Background -Phosphatidylcholine Transfer Protein (PCTP) regulates the intermembrane transfer of phosphatidylcholine (PC). Higher platelet PCTP expression is associated with increased platelet responses upon activation of protease-activated receptor 4 (PAR4) thrombin receptors noted in black subjects as compared to white subjects. Little is known regarding regulation of platelet PCTP Haplodeficiency of RUNX1, a major hematopoietic transcription factor, is associated with thrombocytopenia and impaired platelet responses upon activation...
July 4, 2017: Circulation
https://www.readbyqxmd.com/read/28665888/a-health-profile-associated-with-excessive-alcohol-use-independently-predicts-aortic-stiffness-over-10-years-in-black-south-africans
#20
Melissa Maritz, Carla M T Fourie, Johannes M van Rooyen, Iolanthe M Kruger, Aletta E Schutte
OBJECTIVE: Black populations exhibit higher arterial stiffness than whites and suffer a disproportionate burden of cardiovascular disease. It is therefore important to identify modifiable health behaviours predicting large artery stiffness in blacks. We examined whether traditional cardiovascular risk factors and health behaviours of black South Africans predict large artery stiffness 10 years later. METHODS: We included 650 HIV-free participants (32.8% men) and collected data in rural and urban areas of the North West Province in 2005 and 2015...
June 29, 2017: Journal of Hypertension
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