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methicillin sensitive staphylococcus aureus

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https://www.readbyqxmd.com/read/29160517/prevalence-and-antibiogram-of-methicillin-resistant-staphylococcus-aureus-isolated-from-medical-device-related-infections-a-retrospective-study-in-lahore-pakistan
#1
Muhammad Sohail, Zakia Latif
INTRODUCTION: With the advancement of medicine and surgery, various types of medical devices have become part of treatment strategies. METHODS: Identification and antimicrobial sensitivity testing were done according to CLSI guidelines following standard microbiological practices. RESULTS: Urinary catheter infections (31%) were most frequent followed by central venous catheter (18%) and orthopedic implants (15%). Methicillin resistant Staphylococcus aureus (MRSA) was a major cause of device-related infection after Escherichia coli (21%); other pathogens were Klebsiella pneumoniae (14%), Pseudomonas spp...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29156865/antibacterial-resistance-patterns-and-incidence-of-hospital-acquired-staphylococcus-aureus-bacteremia-in-a-tertiary-care-educational-hospital-in-turkey-a-perspective-from-2001-to-2013
#2
Oğuz Reşat Sipahi, Serhat Uysal, Sabire Şöhret Aydemir, Hüsnü Pullukçu, Meltem Taşbakan, Alper Tünger, Fatma Feriha Çilli, Tansu Yamazhan, Bilgin Arda, Hilal Sipahi, Sercan Ulusoy
Background/aim: Staphylococcus aureus is an important nosocomial pathogen and a successful antimicrobial-resistance developer. In this study we retrospectively evaluated the resistance patterns and incidence of microbiologically confirmed nosocomial bacteremia (MCNB) related S. aureus strains between 2001 and 2013. Materials and methods: Any patient in whom S. aureus was isolated in at least one set of blood cultures (sent to the bacteriology laboratory 72 h after hospital admission) was considered to have MCNB...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29151993/antibiotic-based-phenotype-and-hospital-admission-profile-are-the-most-likely-predictors-of-genotyping-classification-of-mrsa
#3
Ali M Bazzi, Jaffar A Al-Tawfiq, Ali A Rabaan, Dianne Neal, Aimee Ferraro, Mahmoud M Fawarah
Background: Methicillin-resistant Staphylococcus aureus (MRSA) infection is associated with increased morbidity, mortality, and financial burdens. Phenotyping methods are used to classify MRSA as either health care MRSA (HA-MRSA) or community-associated MRSA (CA-MRSA). Recent studies suggested the phenotyping methods are not always reliable, based on a lack of concordance with genotyping results. Objective: In this study, concordance of classification methods based on clinical characteristics or antibiotic susceptibility compared to the gold standard genotyping was assessed in the classification of MRSA...
2017: Open Microbiology Journal
https://www.readbyqxmd.com/read/29151645/management-of-staphylococcus-mediated-systemic-infection-by-enhancing-the-resurging-activity-of-co-trimoxazole-in-presence-of-cryptdin-2
#4
Amrita Kaur, Shiv Kumar Chabba, Ujjwal Jit Kaur, Arashdeep Kaur, Simran Preet, Praveen Rishi
Resurgence of sensitivity of the antibiotics, to which the pathogen had developed resistance in the past, requires special attention for strengthening the reservoir of antimicrobial compounds. Reports in the recent past have suggested that co-trimoxazole (COT) has regained its activity against methicillin resistant Staphylococcus aureus (MRSA). The present study exploited the use of COT in the presence of an antimicrobial peptide (AMP), cryptdin-2 (a murine Paneth cell alpha defensin), in order to reduce the selective pressure of the antibiotic on the pathogen...
December 2017: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29142545/rapid-screening-of-pyogenic-staphylococcus-aureus-for-confirmation-of-genus-and-species-methicillin-resistance-and-virulence-factors-by-using-two-novel-multiplex-pcr
#5
Abdul Haque, Asma Haque, Muhammad Saeed, Aysha Azhar, Samreen Rasool, Sidra Shan, Beenish Ehsan, Zohaib Nisar
Objectives: Emergence of methicillin resistant Staphylococcus aureus (MRSA) is a major medical problem of current era. These bacteria are resistant to most drugs and rapid diagnosis can provide a clear guideline to clinicians. They possess specific virulence factors and relevant information can be very useful. We designed this study to develop multiplex PCRs to provide rapid information. Methods: We studied 60 Staphylococcus aureus isolates and detected methicillin resistance by cefoxitin sensitivity and targeting of mecA gene...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29136469/novel-linear-lipopeptide-paenipeptins-with-potential-for-eradicating-biofilms-and-sensitizing-gram-negative-bacteria-to-rifampicin-and-clarithromycin
#6
Sun Hee Moon, Xuan Zhang, Guangrong Zheng, Daniel G Meeker, Mark S Smeltzer, En Huang
We report the structure-activity relationship (SAR) analyses of 17 linear lipopeptide paenipeptin analogues. Analogues 7, 12 and 17 were more potent than the lead compound. Analogue 17 was active against carbapenem-resistant and polymyxin-resistant pathogens. This compound at 40 μg/mL resulted in 3 log and 2.6 log reductions of methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa, respectively, in catheter-associated biofilms in vitro. Analogue 17 showed little hemolysis at 32 µg/ml and lysed 11% of red blood cells at 64 µg/ml...
November 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29133214/antibacterial-activity-and-pharmacokinetic-profile-of-a-promising-antibacterial-agent-14-o-4-amino-6-hydroxy-pyrimidine-2-yl-thioacetyl-mutilin
#7
Ruofeng Shang, Yunpeng Yi, Chao Zhang, Yunxing Fu, Jianping Liang, Wanxia Pu
A new pleuromutilin derivative, 14-O-[(4-Amino-6-hydroxy-pyrimidine-2-yl)thioacetyl] mutilin (APTM), has been synthesized and proved most potent antibacterial agent in in vitro assays, suggesting that further development of this compound may lead to a promising antibacterial drug. In this study, we further evaluated the cytotoxicity, antibacterial efficacy and the pharmacokinetic profile of APTM. In BRL 3A cells, 50% of viability was obtained when 363μg/mL of APTM was used, while retapamulin and tiamulin fumarate needed 49 and 28μg/mL, respectively, to reach this viability...
November 10, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29133025/perivalvular-mitral-abscess-fistulised-to-the-pericardial-cavity-revealing-staphylococcal-endocarditis
#8
Paul Desaint, Anthony Chauvat, Thomas Garaud, Olivier Andremont, Gaëtan Plantefève, Hervé Mentec, Damien Contou
BACKGROUND: Fistula to the pericardial cavity is a very rare complication of perivalvular abscess during infective endocarditis, with Staphylococcus aureus being the most commonly associated microorganism. METHODS: We report a fatal septic shock due to a mitral endocarditis revealed by a myocardial abscess fistulised toward the pericardial cavity. RESULTS: A 66-year-old female without previous valvular disease was admitted to intensive care for severe sepsis...
October 31, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29123505/staphylococcus-aureus-in-some-brazilian-dairy-industries-changes-of-contamination-and-diversity
#9
Karen K Dittmann, Luíza T Chaul, Sarah H I Lee, Carlos H Corassin, Carlos A Fernandes de Oliveira, Elaine C Pereira De Martinis, Virgínia F Alves, Lone Gram, Virginie Oxaran
Staphylococcus aureus, a major food-poisoning pathogen, is a common contaminant in dairy industries worldwide, including in Brazil. We determined the occurrence of S. aureus in five dairies in Brazil over 8 months. Of 421 samples, 31 (7.4%) were positive for S. aureus and prevalence varied from 0 to 63.3% between dairies. Sixty-six isolates from the 31 samples were typed by Multi-Locus Sequence Typing to determine if these isolates were persistent or continuously reintroduced. Seven known sequence types (STs), ST1, ST5, ST30, ST97, ST126, ST188 and ST398, and four new ST were identified, ST3531, ST3540, ST3562 and ST3534...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29119029/rhabdomyolysis-induced-by-coadministration-of-fusidic-acid-and-atorvastatin-a-case-report-and-comprehensive-review-of-the-literature
#10
Dimitrios Patoulias, Theodoros Michailidis, Thomas Papatolios, Rafael Papadopoulos, Petros Keryttopoulos
Statins are among the most widely prescribed medications worldwide. Acute rhabdomyolysis constitutes a potentially life-threatening side effect regardless of whether statins are administered alone or in combination. The potentially fatal combination of a statin and fusidic acid has been well described in the literature. Acute renal failure can be a direct consequence of this drug-drug interaction. We present a case of a 79-year-old woman who presented to our Emergency Department with a one-week history of limb weakness, myalgia, and inability to stand and walk...
2017: Case Reports in Nephrology
https://www.readbyqxmd.com/read/29118165/multicenter-evaluation-of-the-xpert-mrsa-nxg-assay-for-detection-of-methicillin-resistant-staphylococcus-aureus-in-nasal-swabs
#11
Melanie L Yarbrough, David K Warren, Karen Allen, Dennis Burkholder, Robert Daum, Curtis Donskey, Dennis Knaack, Anthony LaMarca, Larissa May, Loren G Miller, David M Parenti, Lance Peterson, Thean Yen Tan, Raymond Widen, Diana R Hernandez, Donna M Wolk, C A Burnham
Healthcare-associated methicillin-resistant Staphylococcus aureus (MRSA) infections are a burden on the healthcare system. Clinical laboratories play a key role in reducing this burden, as timely identification of MRSA colonization or infection facilitates infection control practices that are effective at limiting invasive MRSA infections. The Xpert MRSA NxG Assay recently received FDA clearance for the direct detection of MRSA from nasal swabs. This multicenter study evaluated the clinical performance characteristics of the Xpert MRSA NxG Assay with prospectively collected rayon nasal swabs (n = 1103) and flocked swab (ESwab) nasal specimens (n = 846)...
November 8, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29105571/accuracy-of-pcr-targeting-different-markers-for-staphylococcus-aureus-identification-a-comparative-study-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-as-the-gold-standard
#12
Mauro M Saraiva, Candice M De Leon, Silvana C Santos, Danilo T Stipp, Miliane M Souza, Lauro Santos Filho, Wondwossen A Gebreyes, Celso J Oliveira
Staphylococcus aureus is considered a major pathogen in veterinary and human medicine, and the emergence of multidrug-resistant strains, such as livestock-associated methicillin-resistant S. aureus, means that reliable, inexpensive, and fast methods are required to identify S. aureus obtained from animal sources. We tested the accuracy of a PCR targeting the genes femA, nuc, and coa in identifying S. aureus from animals. A total of 157 Staphylococcus spp. isolates were examined by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry; 18 different Staphylococcus species were identified...
November 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29100874/can-preoperative-nasal-cultures-of-staphylococcus-aureus-predict-infectious-complications-or-outcomes-following-repair-of-fracture-nonunion
#13
David P Taormina, Sanjit R Konda, Frank A Liporace, Kenneth A Egol
INTRODUCTION: Much has been studied with reference to methicillin resistant Staphylococcus aureus (MRSA) and methicillin sensitive S. aureus (MSSA) colonization and associated outcomes and comorbidities. In the area of Orthopedic surgery, literature predominantly comes from the field of arthroplasty. Little is known about outcomes of fracture and Orthopedic trauma patients in the setting of S. aureus colonization. We believe that MRSA/MSSA colonization in and of itself may be a weak marker for generally poor protoplasm, potentially with complex medical history including previous hospitalization or rehab placement...
October 31, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/29100712/-quercetin-attenuates-staphylococcus-aureus-virulence-by-reducing-alpha-toxin-secretion
#14
Gabriela Carrada López, Carlos A Castañón Sánchez
Alpha toxin, a pore-forming protein with cytotoxic activity, is one of the major virulence factors secreted by most strains of Staphylococcus aureus. The relevance of this protein in the pathogenesis of pneumonia associated with S.aureus infections has already been established. Therefore, inhibiting alpha toxin secretion can be an alternative for controlling these infections. This study shows that quercetin, a naturally occurring flavonoid, inhibits hemolytic activity in a dose-dependent manner and reduces alpha toxin secretion in culture supernatants of methicillin-sensitive and methicillin-resistant S...
October 31, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29092997/the-orthopaedic-manifestation-and-outcomes-of-methicillin-sensitive-staphylococcus-aureus-septicaemia
#15
D Makki, T Elgamal, P Evans, D Harvey, G Jackson, S Platt
AIMS: The aim of this paper was to present the clinical features of patients with musculoskeletal sources of methicillin-sensitive Staphylococcus aureus (MSSA) septicaemia. PATIENTS AND METHODS: A total of 137 patients presented with MSSA septicaemia between 2012 and 2015. The primary source of infection was musculoskeletal in 48 patients (35%). Musculoskeletal infection was considered the primary source of septicaemia when endocarditis and other obvious sources were excluded...
November 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29089777/correlation-between-resistance-mechanisms-in-staphylococcus-aureus-and-cell-wall-and-septum-thickening
#16
Ana Belén García, José Manuel Viñuela-Prieto, Laura López-González, Francisco Javier Candel
PURPOSE: The aim of the present study is to examine cell wall and septum thickening of methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant S. aureus (MRSA), and methicillin- and linezolid-resistant S. aureus (MLRSA) isolates by transmission electron microscopy to correlate the association of resistance mechanisms with major changes in the morphology of membrane or septum. MATERIALS AND METHODS: MSSA, MRSA, and MLRSA strains obtained from clinical samples of an outbreak that occurred in 2010 at the Intensive Care Unit of our Hospital were thawed and sown at 37°C in blood agar overnight...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29089242/first-description-of-a-catalase-negative-staphylococcus-aureus-from-a-healthy-carrier-with-a-novel-nonsense-mutation-in-the-kata-gene
#17
Krisztina Laub, Katalin Kristóf, Tamás Tirczka, Adrienn Tóthpál, Szilvia Kardos, Eszter Kovács, Judit Sahin-Tóth, Andrea Horváth, Orsolya Dobay
We have screened 2568 healthy individuals (mostly children) for Staphylococcus aureus and Streptococcus pneumoniae nasal carriage between 2010 and 2012. Out of the isolated 751 S. aureus strains, we found one methicillin-sensitive catalase-negative S. aureus (CNSA). Our CNSA isolate possessed a novel nonsense point mutation in the katA gene leading to early truncation of the protein product. The strain was resistant to penicillin and erythromycin, but sensitive to all other tested antibiotics and carried the enterotoxin A gene...
October 26, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29084070/utility-of-soft-tissue-lateral-neck-radiographs-in-the-emergency-department-the-5-year-experience-of-a-large-tertiary-care-pediatric-hospital
#18
Tais Sao Pedro, Dennis Scolnik, Jeffrey Traubici, Derek Stephens
INTRODUCTION: Although retropharyngeal infection (RPI) may present with voice change, drooling, fever, and a toxic appearance, diagnosis based on symptoms alone is unreliable. As incidence is increasing in children and drug-resistant bacterial strains such as methicillin-resistant Staphylococcus aureus are becoming more common, we decided to assess the clinical utility of lateral neck radiography. OBJECTIVE: The aim of this study was to review the experience of a large tertiary care pediatric emergency department (ED) in using lateral soft tissue neck radiographs in the diagnosis of suspected RPI...
October 27, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29081854/toxic-shock-in-children-with-bone-and-joint-infections-a-review-of-seven-years-of-patients-admitted-to-one-intensive-care-unit
#19
D L Kerr, E K Loraas, A C Links, T V Brogan, G A Schmale
PURPOSE: The objective of this study was to compare the frequency of severe systemic, multi-organ involvement and toxic shock syndrome (TSS) in patients with Staphylococcus aureus (SA) and Group A β-haemolytic Streptococcus pyogenes (GABS) bone and joint infections. METHODS: We retrospectively reviewed patients treated for septic arthritis or osteomyelitis at one children's hospital between 2002 and 2009. The rates of intensive care unit (ICU) admission for methicillin-sensitive SA (MSSA), methicillin-resistant SA (MRSA) and GABS infections were compared, as were the lengths of stay, number of surgeries, operative procedures and cases of TSS...
October 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29081676/possible-involvement-of-ros-generation-in-vorinostat-pretreatment-induced-enhancement-of-the-antibacterial-activity-of-ciprofloxacin
#20
Majed M Masadeh, Karem H Alzoubi, Sayer I Al-Azzam, Ahlam M Al-Buhairan
The mechanism underlying ciprofloxacin action involves interference with transcription and replication of bacterial DNA and, thus, the induction of double-strand breaks in DNA. It also involves elevated oxidative stress, which might contribute to bacterial cell death. Vorinostat was shown to induce oxidative DNA damage. The current work investigated a possible interactive effect of vorinostat on ciprofloxacin-induced cytotoxicity against a number of reference bacteria. Standard bacterial strains were Escherichia coli ATCC 35218, Staphylococcus aureus ATCC29213, Pseudomonas aeruginosa ATCC 9027, Staphylococcus epidermidis ATCC 12228, Acinetobacter baumannii ATCC 17978, Proteus mirabilis ATCC 12459, Klebsiella pneumoniae ATCC 13883, methicillin-resistant Staphylococcus aureus (MRSA) (ATCC 43300), and Streptococcus pneumoniae (ATCC 25923)...
2017: Clinical Pharmacology: Advances and Applications
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