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methicillin sensitive staphylococcus aureus

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https://www.readbyqxmd.com/read/29775628/-cost-effectiveness-of-interventions-to-improve-hand-hygiene-in-healthcare-workers-in-middle-income-hospital-settings-a-model-based-analysis
#1
Nantasit Luangasanatip, Maliwan Hongsuwan, Yoel Lubell, Direk Limmathurotsakul, Pramot Srisamang, Nicholas Pj Day, Nicholas Graves, Ben S Cooper
BACKGROUND: Multimodal interventions are effective in increasing hand hygiene (HH) compliance amongst healthcare workers, but it is not known whether such interventions are cost-effective outside high-income countries. AIM: To evaluate the cost-effectiveness of multimodal hospital interventions to improve hand hygiene (HH) compliance in a middle-income country. METHOD: We adopted a conservative approach by developing a model to determine whether reductions in Methicillin-resistant Staphylococcus aureus bloodstream infections (MRSA-BSI) alone would make HH interventions cost-effective in intensive care units (ICUs)...
May 15, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29773450/acromioclavicular-joint-septic-arthritis-in-an-immunocompetent-child-a-case-report
#2
Saurabh Dutt, Jeetendra Lodhi, Vinod Kumar, Abhishek Kashyap
Septic arthritis of acromioclavicular (AC) joint is a rare entity. It is generally seen in patients who are immunocompromised. Only 15 cases have been reported till now, with only one case series of 6 patients. We report a case of septic arthritis of AC joint in an immunocompetent child. A 9 years old girl presented with history of pain in left shoulder for 4 days associated with fever. No history suggestive of any immunocompromised state was complained. On local examination, a swelling of around 3 cm in diameter was found over left AC joint region with raised local temperature, tenderness on palpation and positive response in fluctuation test...
March 23, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29772647/the-antimicrobial-activity-of-annona-emarginata-schltdl-h-rainer-and-most-active-isolated-compounds-against-clinically-important-bacteria
#3
Juan G Dolab, Beatriz Lima, Ewelina Spaczynska, Jiri Kos, Natividad H Cano, Gabriela Feresin, Alejandro Tapia, Francisco Garibotto, Elisa Petenatti, Monica Olivella, Robert Musiol, Josef Jampilek, Ricardo D Enriz
Annona emarginata (Schltdl.) H. Rainer, commonly known as "arachichú", "araticú", "aratigú", and "yerba mora", is a plant that grows in Argentina. Infusions and decoctions are used in folk medicine as a gargle against throat pain and for calming toothache; another way to use the plant for these purposes is chewing its leaves. Extracts from bark, flowers, leaves, and fruits from A. emarginata were subjected to antibacterial assays against a panel of Gram (+) and Gram (-) pathogenic bacteria according to Clinical and Laboratory Standards Institute protocols...
May 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29769279/microbial-interactions-in-the-cystic-fibrosis-airway
#4
Ann M Granchelli, Frederick R Adler, Ruth H Keogh, Christiana Kartsonaki, David R Cox, Theodore G Liou
Interactions in the airway ecology of cystic fibrosis may alter organism persistence and clinical outcomes. Better understanding of such interactions could guide clinical decisions. We fitted logistic regression models using generalized estimating equations to longitudinal two-year patient cohorts in the Cystic Fibrosis Foundation Patient Registry, 2003-2011 to study associations between airway organisms present in each calendar year and their presence in the subsequent year. Models were adjusted for clinical characteristics and multiple observations per patient and tested for sensitivity to cystic fibrosis-specific treatments...
May 16, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29764833/early-prosthetic-valve-endocarditis-after-transcatheter-aortic-valve-implantation-using-st-jude-medical-portico-valve
#5
Abdalla Ibrahim, Aneeq Ahmed, Thomas Kiernan, Samer Arnous
An 87-year-old woman presented to the emergency department with a 2-week history of progressively worsening shortness of breath, fever and generalised myalgia. She underwent a transcatheter Portico aortic valve implantation for severe symptomatic aortic stenosis 3 months prior to this presentation. Examination revealed a temperature of 40°C and a systolic murmur in the aortic area. Inflammatory markers were elevated, and blood cultures were positive for methicillin-sensitive Staphylococcus aureus A possible diagnosis of infective endocarditis was made as one major and one minor criterion in the modified Duke criteria were fulfilled...
May 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29764754/detection-of-methicillin-resistant-coagulase-negative-staphylococci-harboring-the-class-a-mec-complex-by-maldi-tof-mass-spectrometry
#6
Dominik Schuster, Michaele Josten, Kathrin Janssen, Isabel Bodenstein, Cathrin Albert, Anna Schallenberg, Mike Gajdiss, Esther Sib, Christiane Szekat, Katja Kehl, Marijo Parčina, Gunnar T R Hischebeth, Gabriele Bierbaum
The aim of this study was to test the identification of methicillin resistance in coagulase-negative staphylococci by routine matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS). SCCmec cassettes of type II, III and VIII encode a small peptide called PSM-mec in the vicinity of mecA. It is visible at m/z 2415 during MALDI-TOF MS of whole cells of Staphylococcus aureus. In view of the fact that psm-mec has been identified in methicillin-resistant coagulase-negative staphylococci, we evaluated a collection of clinical coagulase-negative staphylococci, that contained 77...
May 8, 2018: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/29758346/electro-responsive-graphene-oxide-hydrogels-for-skin-bandages-the-outcome-of-gelatin-and-trypsin-immobilization
#7
Mariagrazia di Luca, Orazio Vittorio, Giuseppe Cirillo, Manuela Curcio, Magdalena Czuban, Florida Voli, Annafranca Farfalla, Silke Hampel, Fiore Pasquale Nicoletta, Francesca Iemma
A free radical polymerization method was adopted for the fabrication of hybrid hydrogel films based on acrylamide and polyethylene glycol dimethacrylate as plasticizing and crosslinking agents, respectively, to be employed as smart skin bandages. Electro-sensitivity, biocompatibility and proteolytic properties were conferred to the final polymer networks by introducing graphene oxide (0.5% w/w), gelatin or trypsin (10% w/w) in the polymerization feed. The physical chemical and mechanical characterization of hybrid materials was performed by means of determination of protein content, Raman spectroscopy, thermogravimetric analysis and measurement of tensile strength...
May 11, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29751844/prevalence-and-antimicrobial-susceptibility-patterns-of-methicillin-resistant-staphylococcus-aureus-among-janitors-of-mekelle-university-north-ethiopia
#8
Atsebaha Gebrekidan Kahsay, Dawit Gebreegziabher Hagos, Getahun Kahsay Abay, Tadele Araya Mezgebo
OBJECTIVE: The objective of this study was to determine the prevalence of methicillin-resistant Staphylococcus aureus and antimicrobial susceptibility patterns among janitors working at Mekelle University, Tigray, Northern Ethiopia. RESULT: The overall prevalence of S. aureus and MRSA in the present study were 17.97% (69/384) and 6.25% (24/384) respectively. Although not statistically significant, the prevalence of MRSA among janitors working in the medical area (9...
May 11, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29750765/ideal-and-actual-impact-of-rapid-diagnostic-testing-and-antibiotic-stewardship-on-antibiotic-prescribing-and-clinical-outcomes-in-children-with-positive-blood-cultures
#9
Caroline H Reuter, Hannah L Palac, Larry K Kociolek, Xiaotian T Zheng, Yusuf Y Chao, Rupal Patel, Sameer J Patel
BACKGROUND: Implementing matrix assisted laser desorption ionization time of flight (MALDI-TOF) and multiplex PCR (mPCR) has been associated with decreased mortality and hospital length of stay in adults, but the impact in pediatrics is less understood. METHODS: This pre-post quasi-experimental study compared antibiotic prescribing for positive blood cultures in patients ≤21 years collected in 2012 (pre-intervention) and in 2015 (after MALDI-TOF/mPCR). Time to effective and optimal antimicrobial therapy were evaluated using Cox proportional hazards regression...
May 10, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29750587/the-microbiologic-profile-of-dacryocystitis
#10
Stella Y Chung, Leon Rafailov, Roger E Turbin, Paul D Langer
PURPOSE: Recent studies suggest an increasing incidence of gram-negative bacteria and methicillin-resistant Staphylococcus aureus in dacryocystitis. Since patients are often treated empirically without culture data, a changing microbiologic profile will markedly affect the success of oral treatment. To provide current guidelines for the treatment of this common condition, we investigated the microbiology and antibiogram of dacryocystitis seen at our institution. METHODS: The charts of all patients presenting with acute and/or chronic dacryocystitis in University Hospital, Newark, from 2007 to 2015 were reviewed...
May 11, 2018: Orbit
https://www.readbyqxmd.com/read/29745308/conservative-treatment-of-non-aneurysmal-infectious-aortitis-a-case-report-and-review-of-the-literature
#11
Jasper Callemeyn, Kim Daenens, Inge Derdelinckx, Steven Dymarkowski, Katleen Fagard
BACKGROUND:  Non-aneurysmal infectious aortitis is a rare clinical entity with most often lethal complications when surgical intervention is delayed. OBJECTIVES:  This report describes the case of a non-aneurysmal infectious aortitis complicated with a penetrating aortic ulcer in an elderly woman, caused by a methicillin-sensitive Staphylococcus aureus. Surgery was deemed contra-indicated and treatment was limited to the administration of intravenous vancomycin (2 grams daily), followed by flucloxacillin (6 times 2 grams daily)...
May 10, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29738654/-multidrug-resistance-e-eskape-strains-isolated-from-blood-cultures-in-patients-with-cancer
#12
Consuelo Velázquez-Acosta, Patricia Cornejo-Juárez, Patricia Volkow-Fernández
OBJECTIVE: To describe the trend of multidrug resistant (MDR) strains isolated from blood in patients with cancer from 2005 to 2015. MATERIAL AND METHODS: 33 127 blood cultures were processed by retrospective analysis. Identification and antimicrobial sensitivity were performed through automated methods: WaLK away (Siemens Labora- tory Diagnostics) and BD Phoenix (Becton, Dickinson and Company). Resistant strains were determined according to the minimum inhibitory concentration, following the parameters of the Clinical and Laboratory Standards Institute (CLSI)...
March 2018: Salud Pública de México
https://www.readbyqxmd.com/read/29735292/delayed-idiopathic-hardware-associated-osteomyelitis-of-the-scaphoid
#13
Jack Burns, Evan Moore, Jacob Maus, Brian Rinker
Osteomyelitis of the carpal bones is rare and usually occurs in the setting of penetrating wounds or immune compromise. A case of hardware-associated scaphoid osteomyelitis is reported in a 33-year-old man who underwent screw fixation of a scaphoid fracture more than 20 years prior to presentation. The patient was treated with operative debridement including a total scaphoidectomy as well as intravenous antibiotics. Methicillin-sensitive Staphylococcus aureus was isolated from intraoperative cultures. A secondary proximal row carpectomy was performed to provide a stable wrist...
May 5, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29731745/autophosphorylation-mechanism-of-the-ser-thr-kinase-stk1-from-staphylococcus-aureus
#14
Weihao Zheng, Xiaodan Cai, Shuiming Li, Zigang Li
The eukaryotic-like Ser/Thr kinase Stk1 is crucial for virulence, cell wall biosynthesis, and drug susceptibility in methicillin-resistant Staphylococcus aureus ( S. aureus ) (MRSA). Importantly, MRSA lacking Stk1 become sensitive to β-lactam antibiotics, implying that Stk1 could be an alternative target for combination therapy. However, the autophosphorylation mechanism of Stk1 remains elusive. Using a phosphoproteomic study, we identified six in vivo phosphorylated activation loop residues (Ser159, Thr161, Ser162, Thr164, Thr166, and Thr172) of Stk1, which are also phosphorylated in vitro ...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29731647/ambulance-vehicles-as-a-source-of-multidrug-resistant-infections-a-multicenter-study-in-assiut-city-egypt
#15
Mohamed A El-Mokhtar, Helal F Hetta
Background: Ambulances may represent a potential source of infection to patients, patients' relatives, and paramedical staffs. In this study, we analyzed the extent of bacterial contamination in ambulance vehicles and measured the degree of antimicrobial resistance among isolated pathogens. Materials and methods: Twenty-five vehicles were included and 16 sampling points were swabbed in each vehicle. Then the swabs were immediately transferred to the laboratory to identify bacterial contaminants utilizing standard microbiological procedures and API® systems...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29724187/effects-of-intestinal-colonization-by-clostridium-difficile-and-staphylococcus-aureus-on-microbiota-diversity-in-healthy-individuals-in-china
#16
Danfeng Dong, Qi Ni, Chen Wang, Lihua Zhang, Zhen Li, Cen Jiang, EnqiangMao, Yibing Peng
BACKGROUND: Intestinal colonization by pathogenic bacteria is a risk factor for infection, and contributes to environmental contamination and disease dissemination. Alteration of gut microbiota also plays a pivotal role in the development of disease. Although Clostridium difficile and Staphylococcus aureus are well-recognized pathogens causing nosocomial and community infections, the intestinal colonization was not fully investigated. Herein, we explored their overall carriage rates in healthy adults from the community, and characterized the gut microbiomes of C...
May 3, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29720966/synergistic-effect-of-diallyl-sulfide-with-zinc-oxide-nanorods-a-novel-and-effective-approach-for-treatment-of-acute-dermatitis-in-model-animals
#17
Mohd A Rauf, Swaleha Zubair, Hira Ateeq, Khadija Dabeer, Subodh Pachauri, Mohd Ajmal, Mohammad Owais
Besides inciting persistent and recurrent nosocomial afflictions, Staphylococcus aureus ( S . aureus ), a biofilm forming pathogen, poses an increased risk of several skin as well as respiratory tract infections as well. Emerging antimicrobial resistance trend asks to search for an alternate non-antibiotic based option to combat S. aureus pathogen. In the present study, we evaluated synergistic antimicrobial potential of Zinc oxide nanorods (ZnO-NRs) and diallyl sulphide (DAS) emulsion against methicillin resistant Staphylococcus aureus (MRSA)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29716725/staphylococcus-aureus-colonization-in-an-institutionalized-elderly-population-long-term-care-facilities-in-the-bay-of-cadiz-area-spain-prevalence-and-associated-risk-factors
#18
María Pérez-Eslava, Nuria López-Ruíz, Elvira María Flores-Cebada, Manuel Rodríguez-Iglesias, Fátima Galán-Sánchez
BACKGROUND AND OBJECTIVE: Staphylococcus aureus is a health problem behind a great variety of infections. The objective of the study was to establish the prevalence and risk factors of S. aureus carriers in community nursing homes in Cadiz. PATIENTS AND METHOD: A cross study from September 2016 to May 2017. POPULATION: All residents institutionalized in the largest long-term care facilities centers in Cadiz. The main variable was being a S...
April 28, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29716704/clinical-microbiological-characterization-and-risk-factors-of-mortality-in-infective-endocarditis-from-a-tertiary-care-academic-hospital-in-southern-india
#19
Prasanna Subbaraju, Shipra Rai, Jwalit Morakhia, Geet Midha, Asha Kamath, Kavitha Saravu
AIMS: To dissect the clinical-microbiological profile of Infective endocarditis (IE) population and to determine the risk factors for IE related mortality. METHODS: A cohort study was conducted using relevant data from clinical records of patients (≥12years) with definite/possible IE from December 2007 to December 2013 and was analyzed using appropriate statistical tests. RESULTS: In the cohort of 139 IE patients, mean age was 47.9±15.8years, with male preponderance (68...
March 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29714149/mupirocin-resistance-among-methicillin-resistant-staphylococcus-isolates-in-a-tertiary-health-care-center
#20
Seema Mittal, Pallavi Sayal
INTRODUCTION-Antibiotics have revolutionized medicine in many respects and countless lives have been saved, their discovery was a turning point in human history. Regrettably, the use of these wonder drugs has been accompanied by the rapid appearance of resistant strains. AIMS &OBJECTIVES-This study was carried out to with the aim to determine the rates of high-level and low-level mupirocin resistance in MRSA, to study the antimicrobial resistance pattern of mupirocin-resistant MRSA and mupirocin-sensitive MRSA...
April 30, 2018: Infectious Disorders Drug Targets
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