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methicillin sensitive staphylococcus aureus

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https://www.readbyqxmd.com/read/28429393/synthesis-and-evaluation-of-thiazolidine-amide-and-n-thiazolyl-amide-fluoroquinolone-derivatives
#1
Isaac Garza, Miranda J Wallace, Dinesh Fernando, Aman Singh, Richard E Lee, Jason S Gerding, Cynthia Franklin, Raghunandan Yendapally
In an effort to develop new fluoroquinolones, we synthesized eight compounds and tested them against a panel of bacteria. The design of these compounds was guided by the introduction of the isothiazoloquinolone motif. The three most active compounds in this series, 8-10, demonstrated good antibacterial activity against methicillin-sensitive Staphylococcus aureus and healthcare-acquired methicillin-resistant Staphylococcus aureus (MIC 0.62-6.3 µg/mL). Further, when these three active compounds were tested for their inhibitory effects on bacterial enzymes, compound 9 was the most effective agent exhibiting IC50 values of 33...
April 21, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28426977/blue-violet-laser-inactivates-methicillin-resistant-staphylococcus-aureus-by-altering-its-transmembrane-potential
#2
Gabriel Biener, Daniela S Masson-Meyers, Violet V Bumah, Grant Hussey, Michael R Stoneman, Chukuka S Enwemeka, Valerica Raicu
The resistance of methicillin-resistant Staphylococcus aureus to antibiotics presents serious clinical problems that prompted the need for finding alternative or combination therapies. One such therapy is irradiation with blue light. To determine the alterations in metabolic processes implicated in the observed antimicrobial effects of blue light, we investigated the changes in membrane potential and the presence of free-radical-producing photo-acceptor molecules. Bacterial cultures irradiated with one or two doses of 405nm laser light (each consisting of 121J/cm(2)) were imaged with spectrally resolved laser-scanning microscopes to detect endogenous fluorescent species as well as the voltage sensitive dye 3,3'-Diethyloxacarbocyanine iodide...
April 6, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28422484/direct-synthesis-of-dextran-based-antibacterial-hydrogels-for-extended-release-of-biocides-and-eradication-of-topical-biofilms
#3
Jiaul Hoque, Jayanta Haldar
Cationic small molecular biocides have been developed as promising antibiofilm agents because of their tunability in chemical structures and ability to disrupt established biofilms. However, the impact of biocides in antibiofilm treatment is largely limited due to lack of an effective delivery system that can ensure sustained release of biocide at the target site. Herein we report biocide-encapsulated antibacterial and antibiofilm hydrogel that acts as efficient delivery vehicle for the biocide and eradicates matured bacterial biofilm...
April 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28422471/-epidemiological-surveillance-for-multidrug-resistant-microorganisms-in-a-general-icu
#4
A Fernández-Verdugo, J Fernández, D Escudero, L Cofiño, L Forcelledo, M Telenti, E García-Prieto, R Rodríguez-García, L Álvarez-García, A Pérez-García, C Rodríguez-Lucas, F Vazquez
OBJECTIVE: Multidrug resistant (MDR) microorganisms represent a threat for patients admitted in Intensive Care Units (ICUs). The objective of the present study is to analyse the results of epidemiological surveillance cultures for these microorganisms in one of these units. METHODS: General ICU. Retrospective analysis, descriptive statistics. Analysis of epidemiological surveillance cultures for MDR microorganisms in 2015. Studied microorganisms: Methicillin-resistant Staphylococcus aureus (MRSA), ESBL-and/or carbapenemase-producing Klebsiella pneumoniae (CESBL-KP) and MDR Acinetobacter baumannii (MDRAB)...
April 5, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28419870/methicillin-resistant-staphylococcus-aureus-nasal-colonisation-amongst-healthcare-workers-in-kurdistan-region-iraq
#5
Nawfal R Hussein, Mahde S Assafi, Tayyaba Ijaz
OBJECTIVES: The aim of this study was to determine the prevalence of nasal carriage of methicillin-resistant Staphylococcus aureus (MRSA) among healthcare workers (HCWs) compared with non-HCWs at Duhok city, Kurdistan Region, northern Iraq. METHODS: A total of 182 HCWs with different occupations and working in different hospital units as well as 198 non-HCWs were recruited. Nasal swab samples were collected and were inoculated on mannitol salt agar and incubated at 35°C for 48h...
April 15, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28417109/intractable-methicillin-resistant-staphylococcus-aureus-otorrhea-with-silicone-impression-in-the-middle-ear
#6
Eun Kyung Jung, Chul Ho Jang, Jong Yuap Seong, Yong Beom Cho
We report a case of methicillin-resistant Staphylococcus aureus (MRSA) otorrhea with impression material of hearing aid in the middle ear. The patient had chronic otitis media in the right ear with sensorineural hearing loss in both ears. The silicone flowed into the middle ear through a tympanic membrane perforation during the process of making an ear mold. Several days after hearing aid fitting, the patient had severe otalgia, intractable otorrhea, aggravated hearing loss, and dizziness. The pus culture and sensitivity test revealed MRSA...
April 2017: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/28414677/a-rare-case-of-tropical-pyomysitis-acquired-on-vacation-in-a-healthy-male
#7
K Poole, T Tran
INTRODUCTION: Pyomyositis has traditionally been considered a tropical disease. Increasing prevalence has been observed in more northern climates, especially with HIV, immunosuppression, and IV drug abuse as predisposing factors. Pyomyositis has the tendency to mimic other conditions, such as muscle contusion, necrotizing fasciitis, or septic arthritis. The rarity of this disease and non-specificity of its symptoms often lead to delay in appropriate diagnosis and treatment. CASE: 24-year-old man, seen 2 days prior in orthopedics clinic and the Emergency Department for persistent gluteal pain thought to be due to right-sided sciatica, was admitted following worsening pain, diffuse generalized weakness with polyarthralgias and myalgias These symptoms were associated with night sweats, shaking chills, and difficulty walking...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28412663/a-facile-rapid-and-sensitive-detection-of-mrsa-using-a-crispr-mediated-dna-fish-method-antibody-like-dcas9-sgrna-complex
#8
Kyeonghye Guk, Joo Oak Keem, Seul Gee Hwang, Hyeran Kim, Taejoon Kang, Eun-Kyung Lim, Juyeon Jung
Rapid and reliable diagnosis of methicillin-resistant Staphylococcus aureus (MRSA) is crucial for guiding effective patient treatment and preventing the spread of MRSA infections. Nonetheless, further simplification of MRSA detection procedures to shorten detection time and reduce labor relative to that of conventional methods remains a challenge. Here, we have demonstrated a Clustered regularly interspaced palindromic repeats (CRISPR)-mediated DNA-FISH method for the simple, rapid and highly sensitive detection of MRSA; this method uses CRISPR associated protein 9/single-guide RNA (dCas9/sgRNA) complex as a targeting material and SYBR Green I (SG I) as a fluorescent probe...
April 13, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28410834/wearing-id-badges-in-the-operating-room-environment-is-reconsideration-warranted
#9
Matthew H Hogue, Kris P Heilmann, John J Callaghan
BACKGROUND: Surgical site infection and nosocomial infections in general have appropriately undergone increased scrutiny over the last decade. Numerous studies have documented pathogenic bacterial contamination of personal items such as cell phones, pagers, ties, and pens in the hospital setting. It is our understanding that Joint Commission on Accreditation of Healthcare Organizations requires all personnel to wear an identification badge at all times, which includes the operating room environment...
February 3, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28407796/prevalence-of-methicillin-resistant-staphylococcus-aureus-mrsa-infection-and-the-molecular-characteristics-of-mrsa-bacteraemia-over-a-two-year-period-in-a-tertiary-teaching-hospital-in-malaysia
#10
Pik San Sit, Cindy Shuan Ju Teh, Nuryana Idris, I-Ching Sam, Sharifah Faridah Syed Omar, Helmi Sulaiman, Kwai Lin Thong, Adeeba Kamarulzaman, Sasheela Ponnampalavanar
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is an established pathogen that causes hospital- and community-acquired infections worldwide. The prevalence rate of MRSA infections were reported to be the highest in Asia. As there is limited epidemiological study being done in Malaysia, this study aimed to determine the prevalence of MRSA infection and the molecular characteristics of MRSA bacteraemia. METHODS: Two hundred and nine MRSA strains from year 2011 to 2012 were collected from a tertiary teaching hospital in Malaysia...
April 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28406770/frequency-and-antibiogram-of-isolates-from-surgical-units-of-a-tertiary-care-hospital-in-quetta
#11
Maria Mushtaq Gill, Muhammad Junaid Khan, Muhammad Asif Nawaz, Sarfraz Khan Janjua
OBJECTIVE: To determine the frequency and antibiogram of the isolates from infected patients in surgical units of a tertiary care hospital. STUDY DESIGN: Cross-sectional, descriptive study. PLACE AND DURATION OF STUDY: Department of Microbiology, Combined Military Hospital, Quetta, from March to October 2015. METHODOLOGY: Clinical samples from the surgical units received in Department of Microbiology for culture and sensitivity were analyzed by Gram stain, culture and biochemical tests for identification of the isolates; and the antibiotic susceptibility was determined by modified Kirby Bauer disc diffusion method...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28397557/factors-associated-with-infectious-laryngitis-a-retrospective-review-of-15-cases
#12
Carissa M Thomas, Marie E Jetté, Matthew S Clary
OBJECTIVES: To identify the culturable microbes associated with infectious laryngitis and outline effective treatment strategies. METHODS: This is a retrospective chart review of adult patients with persistent dysphonia plus evidence of laryngeal inflammation who underwent biopsy for culture at a tertiary care medical center. Demographic factors, symptoms as reported on validated patient assessment tools, past medical history, social history, culture results, and treatment duration and response were reviewed...
May 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28394746/stochasticity-among-antibiotic-resistance-profiles-of-common-burn-related-pathogens-over-a-six-year-period
#13
Zachary J Collier, Lawrence J Gottlieb, John C Alverdy
BACKGROUND: One of the most significant contributors to morbidity and death in patients with burns is infection, which accounts for 30%-75% of post-burn fatalities. Because of concerns for the development of antibiotic resistance in burn-related pathogens, the aims of this study were to identify antibiotic resistance trends for the four most common burn-related pathogens over a six-year period. PATIENTS AND METHODS: The study used prospectively collected and de-identified aggregate data for all burn patients admitted to the burn unit between 2009 and 2014...
April 2017: Surgical Infections
https://www.readbyqxmd.com/read/28393935/how-are-the-ancient-cystic-fibrosis-patients-cystic-fibrosis-diagnosed-over-60-years-old
#14
C Prados, M Lerín, J J Cabanillas, L Gómez-Carrera, R Álvarez-Sala
BACKGROUND AND AIMS: To specify the prevalence of patients diagnosed with CF at age of ≥60 year-old and to analyze their characteristics. PATIENTS AND METHODS: Observational study of CF patients which were diagnosed at age ≥60 year-old. The analyzed variables were: age, sex, nationality, lung function parameters, conditions present at diagnosis, microbiological characteristics and genetic findings. RESULTS: eight patients were included...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28393073/a-comparative-study-of-oral-microbiota-in-infants-with-complete-cleft-lip-and-palate-or-cleft-soft-palate
#15
Agnieszka Machorowska-Pieniążek, Anna Mertas, Małgorzata Skucha-Nowak, Marta Tanasiewicz, Tadeusz Morawiec
Few reports have been published on the early microbiota in infants with various types of cleft palate. We assessed the formation of the oral microbiota in infants with complete cleft lip and palate (CLP n = 30) or cleft soft palate (CSP n = 25) in the neonatal period (T1 time) and again in the gum pad stage (T2 time). Culture swabs from the tongue, palate, and/or cleft margin at T1 and T2 were taken. We analysed the prevalence of the given bacterial species (the percentage) and the proportions in which the palate and tongue were colonised by each microorganism...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28389278/prenylated-flavonoids-from-the-stems-and-roots-of-tripterygium-wilfordii
#16
Yang Chen, Jianping Zhao, Yixing Qiu, Hanwen Yuan, Shabana I Khan, Nusrat Hussain, M Iqbal Choudhary, Feng Zeng, De-An Guo, Ikhlas A Khan, Wei Wang
Phytochemical investigation on the stems and roots of Tripterygium wilfordii led to the isolation and characterization of three new prenylated flavanones, tripteryols A-C (1-3), along with (±)-5,4'-dihydroxy-2'-methoxy-6',6″-dimethypyraro-(2″,3″:7,8)-6-methyflavanone (4), and ((2S)-5,7,4'-trihydroxy-2'-methoxy-8,5'-di(3-methyl-2-butenyl)-6-methylflavanone (5). Structures of the compounds 1-5 were elucidated using spectroscopic techniques, such as UV, IR, NMR (1D and 2D), and HRESI-MS. Tripteryols B (2) was found active in the antimicrobial assay against Cryptococcus neoformans, Pseudomonas aeruginosa, vancomycin-resistant Enterococcus faecalis (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) with IC50 values in the range of 2...
April 5, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28383394/methicillin-resistant-staphylococcus-aureus-as-a-uropathogen-in-an-irish-setting
#17
Aisling T Looney, Elaine J Redmond, Naomi M Davey, Padraig J Daly, Carole Troy, Brian F Carey, Ivor M Cullen
Urinary tract infections are one of the most common infectious diseases diagnosed in the community and in the hospital setting. Their treatment is complicated by drug-resistant pathogens and the colonization by microbes of indwelling urinary catheters. This study assessed the occurrence and antimicrobial susceptibility of methicillin-resistant Staphylococcus aureus (MRSA) uropathogens isolated for 5 consecutive years at University Hospital Waterford between 2010 and 2014. We created 4 clinically relevant subdivisions, based on urine source: hospital inpatients, patients from the Emergency Department, patients referred from their General Practitioner, and Nursing Home patients...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28381601/a-novel-multiplex-pcr-assay-for-the-detection-of-chlorhexidine-quaternary-ammonium-mupirocin-and-methicillin-resistance-genes-with-simultaneous-discrimination-of-staphylococcus-aureus-from-coagulase-negative-staphylococci
#18
Jo-Ann McClure, Johanna Zaal DeLongchamp, John M Conly, Kunyan Zhang
Methicillin-resistant Staphylococcus aureus (MRSA) is a clinically significant pathogen resistant to a wide variety of antibiotics and responsible for a large number of nosocomial infections worldwide. The Agency for Healthcare Research and Quality and the Centers for Disease Control and Prevention recently recommended to adopt universal mupirocin/chlorhexidine decolonization of all admitted intensive care unit patients, rather than MRSA screening with targeted treatments, which raises the serious concern about the selection of resistance to mupirocin and chlorhexidine in strains of staphylococci...
April 5, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28379366/definitive-treatment-for-methicillin-sensitive-staphylococcus-aureus-bacteremia-data-versus-a-definitive-answer
#19
Adolf W Karchmer
No abstract text is available yet for this article.
March 31, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28378802/histones-from-avian-erythrocytes-exhibit-antibiofilm-activity-against-methicillin-sensitive-and-methicillin-resistant-staphylococcus-aureus
#20
Megan Rose-Martel, Garima Kulshreshtha, Nahom Ahferom Berhane, Joelle Jodoin, Maxwell T Hincke
Staphylococcus aureus, a human pathogen associated with many illnesses and post-surgical infections, can resist treatment due to the emergence of antibiotic-resistant strains and through biofilm formation. The current treatments for chronic biofilm infections are antibiotics and/or surgical removal of the contaminated medical device. Due to higher morbidity and mortality rates associated with overuse/misuse of antibiotics, alternate treatments are essential. This study reports the antibiofilm activity of avian erythrocyte histones against methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA)...
April 5, 2017: Scientific Reports
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