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tuberculous meningitis prognostic markers

Haruyuki Ariga, Nobuyuki Harada
The progress of genomic analysis in mycobacterium including M. tuberculosis (Mtb) allowed us to find Mtb-specific antigens, ESAT-6 and CFP-10, which induce strong interferon-gamma (IFN-gamma) from sensitized T cells. Shortly after discovery of these antigens, diagnostic tests for tuberculosis (TB) infection were developed using these antigens. Since ESAT-6 and CFP-10 are absent from all BCG substrains and most of non-tuberculous mycobacterium, these diagnostic tests are not confounded with BCG vaccination and infection of most of non-tuberculosis mycobacterium...
September 2008: Kekkaku: [Tuberculosis]
M Sharma, N Nand
OBJECTIVES: Lactic dehydrogenase (LDH), creatine kinase (CK) and gamma glutamyl transpeptidase (GGTP) were measured serially in cerebrospinal fluid (CSF) and serum in twenty five cases of meningitis and an equal number of age and sex matched healthy control subjects with an aim to find out their diagnostic and prognostic significance in cases of meningitis. METHODS: The enzymatic activity was measured serially (day 0, 4th and 7th) in cerebrospinal fluid (CSF) and serum in twenty-five cases of meningitis consisting of fifteen cases of pyogenic meningitis (PM) and ten of tuberculous meningitis (TBM) and an equal number of age and sex matched healthy control...
February 2006: Journal of the Association of Physicians of India
K H Chan, R T F Cheung, C Y Fong, K L Tsang, W Mak, S L Ho
BACKGROUND: Hydrocephalus is a common complication of tuberculous meningitis (TBM). AIM: To study the incidence, associated clinical features, and impact on outcome of hydrocephalus at presentation in TBM. DESIGN: Observational study. SETTING: Regional hospital serving 500,000 people. METHODS: Adult patients with TBM were studied over 57 months. Those with hydrocephalus on initial CT scan were assessed by neurosurgeons...
September 2003: QJM: Monthly Journal of the Association of Physicians
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