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https://www.readbyqxmd.com/read/29785270/distant-lung-metastases-caused-by-a-histologically-benign-phosphaturic-mesenchymal-tumor
#1
Maria P Yavropoulou, Christos Poulios, Christoforos Foroulis, Symeon Tournis, Prodromos Hytiroglou, Kalliopi Kotsa, Isaak Kessisoglou, Pantelis Zebekakis
Tumor-induced osteomalacia (TIO) is a rare form of hypophosphatemia usually caused by phosphaturic mesenchymal tumors (PMTs); the biologic behavior of PMTs is under investigation. Herein we present a case of TIO with a protracted course over 12 years leading to a fatal outcome. A 39-year-old man presented with weakness in 2004 and was found to have decreased serum phosphorus, phosphaturia and low levels of 1,25-dihydroxyvitamin D3. Four years later he developed a painful left calf mass. The lesion was resected, but recurred causing extreme pain and dysfunction...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29766758/anti-inflammatory-peptide-attenuates-edema-and-promotes-bmp-2-induced-bone-formation-in-spine-fusion
#2
Juliane D Glaeser, Khosrowdad Salehi, Linda Kanim, Dmitriy Sheyn, Zachary NaPier, Phillip Behrens, Leslie Garcia, Jason M Cuéllar, Hyun W Bae
Recombinant human bone morphogenic protein-2 (BMP-2) loaded absorbable collagen sponges (ACS) have been successfully used to enhance bone formation and to induce spinal fusion in humans. However, side effects, such as soft-tissue edema and inflammation, have been reported. NEMO binding domain peptide (NBD) inhibits activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a central regulator of immune response. In this study, we investigated NBD's potential to reduce BMP-2-induced soft-tissue inflammation without affecting BMP-2-mediated spinal fusion in rat...
May 16, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29762324/a-giant-congenital-soft-tissue-sinonasal-fibromyxoma-of-the-nose-in-a-newborn-baby
#3
Nur Yucel Ekici, Gül Yucel, Suheyl Haytoğlu, Özgür Küllahci
Myxomas of the nose are very rare benign neoplasms. They grow slowly, infiltrate the surrounding bone cortex, and develop multiple local recurrences with no distant metastasis. Almost, even knowing seen at any age, it is very rare in newborn. The authors present a patient with sinonasal soft tissue fibromyxoma in a newborn baby nose followed by the literature.
May 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29761472/cranial-morphology-in-mollisquama-sp-squaliformes-dalatiidae-and-patterns-of-cranial-evolution-in-dalatiid-sharks
#4
John S S Denton, John G Maisey, Mark Grace, Alan Pradel, Michael H Doosey, Henry L Bart, Gavin J P Naylor
Dalatiid sharks are members of a family of predominantly small, midwater meso- and bathypelagic chondrichthyans. The family is notable for both its number of monotypic genera and high morphological disparity. Three of the seven dalatiid genera are known only from holotype specimens (Mollisquama parini) or from only a handful of specimens (Euprotomicroides zantedeschia, Heteroscymnoides marleyi), with the only detailed anatomical work consistent across all taxa being studies of dentition. Here, we present detailed anatomical description of the second-ever specimen of Mollisquama (Mollisquama sp...
May 14, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29755529/intramuscular-infiltrating-lipoma-of-the-floor-of-the-mouth
#5
Ben-Zion Joshua, Lipa Bodner, Ruthy Shaco-Levy
Lipoma is a very common soft tissue neoplasm, but only infrequently found in the oral region. Intramuscular lipoma (IML) is a relatively common variant of lipoma. The most common site for IML is the large muscles of the extremities, and it is quite rare in the oral cavity. A case of IML affecting the floor of the mouth/tongue of a 42-year-old female is described. The patient presented with a 4 cm diameter yellow mass in the right side of the sublingual area. Axial and coronal magnetic resonance imaging demonstrated its infiltrating nature that can be distinguished from the ordinary well-encapsulated lesion...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29755278/orbital-tumor-associated-with-a-microphthalmic-eye-and-colobomatous-cleft-pilocytic-astrocytoma-glioma-or-massive-retinal-gliosis
#6
Rita Van Ginderdeuren, Rafael Sciot, Ilse Mombaerts
A 11-year-old boy with congenital microphthalmos of the right eye presented with gradual protrusion of his ocular prosthesis. MRI showed an orbital mass adjacent to the microphthalmic eye. After removal of the eye and the orbital soft tissue mass a gliotic mass, resembling a pilocytic astrocytoma WHO grade 1 (glioma) was diagnosed. Through a colobomatous cleft in the eye the tumour spread in the orbit. There were no clinical signs of neurofibromatosis 1. This case showed a very rare association between a microphthalmic and colobomatous eye and pilocytic astrocytoma, grade 1...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29753912/biomimetic-soft-fibrous-hydrogels-for-contractile-and-pharmacologically-responsive-smooth-muscle
#7
Yonghui Ding, Xin Xu, Sadhana Sharma, Michael Floren, Kurt Stenmark, Stephanie J Bryant, Corey P Neu, Wei Tan
The ability to assess changes in smooth muscle contractility and pharmacological responsiveness in normal or pathological-relevant vascular tissue environments is critical to enable vascular drug discovery. However, major challenges remain in both capturing the complexity of in vivo vascular remodeling and evaluating cell contractility in complex, tissue-like environments. Herein, we developed a biomimetic fibrous hydrogel with tunable structure, stiffness, and composition to resemble the native vascular tissue environment...
May 10, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29746273/therapeutic-engineered-hydrogel-coatings-attenuate-the-foreign-body-response-in-submuscular-implants
#8
Katrina A Harmon, Brooks A Lane, Rachel E Boone, Ashkan Afshari, Henrik O Berdel, Michael J Yost, Richard L Goodwin, Harold I Friedman, John F Eberth
BACKGROUND: Biomedical devices are implanted into mammalian soft tissues to improve, monitor, or restore form or function. The utility of these implants is limited by the subsequent foreign body response (FBR), beginning with inflammation and terminating in a collagen envelope around the device, known as the capsule. This capsule then can contract and distort the shape of the device or limit its effectiveness in interacting with the surrounding host tissues. In the current study, we investigated the effect of therapeutic collagen-coated silicone discs in a rat model of the FBR...
April 30, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29744457/alginate-nanobeads-interspersed-fibrin-network-as-in-situ-forming-hydrogel-for-soft-tissue-engineering
#9
S Deepthi, R Jayakumar
Hydrogels are a class of materials that has the property of injectability and in situ gel formation. This property of hydrogels is manipulated in this study to develop a biomimetic bioresorbable injectable system of alginate nanobeads interspersed in fibrin network. Alginate nanobeads developed by calcium cross-linking yielded a size of 200-500 nm. The alginate nanobeads fibrin hydrogel was formed using dual syringe apparatus. Characterization of the in situ injectable hydrogel was done by SEM, FTIR and Rheometer...
June 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29731882/autologous-stem-cell-transplantation-in-ebv-positive-post-renal-transplant-refractory-multiple-myeloma-a-case-report-and-literature-review
#10
Xiaobao Xie, Yan Lin, Yang Cao, Weimin Dong, Wei Wu, Yuandong Zhu, Deliang Liu, Haiqian Li, Qing Li, Weiying Gu
Renal transplant recipients exhibit an increased risk of developing plasma cell neoplasms (PCNs; comprising multiple myeloma and plasmacytoma); however, multiple myeloma manifesting with refractory extramedullary plasmacytomas associated with Epstein-Barr virus are markedly rare in these patients. In the present case report, an unusual case of refractory multiple myeloma with multiple extramedullary plasmacytoma (including liver, vertebrae, breast, muscle, skin and soft tissues) was presented. The patient exhibited mild bone marrow infiltration which was successfully treated with novel agents, including bortezomib and lenalidomide, followed by autologous stem cell transplantation (ASCT)...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29713889/acellular-dermal-matrix-allograft-versus-free-gingival-graft-a-histological-evaluation-and-split-mouth-randomized-clinical-trial
#11
Daniel Romeu Benchimol de Resende, Sebastião Luiz Aguiar Greghi, Aline Franco Siqueira, César Augusto Magalhães Benfatti, Carla Andreotti Damante, Mariana Schutzer Ragghianti Zangrando
OBJECTIVES: This split-mouth controlled randomized clinical trial evaluated clinical and histological results of acellular dermal matrix allograft (ADM) compared to autogenous free gingival graft (FGG) for keratinized tissue augmentation. MATERIAL AND METHODS: Twenty-five patients with the absence or deficiency of keratinized tissue (50 sites) were treated with FGG (control group) and ADM (test group). Clinical parameters included keratinized tissue width (KTW) (primary outcome), soft tissue thickness (TT), recession depth (RD), probing depth (PD), and clinical attachment level (CAL)...
April 30, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29705002/validation-of-peripheral-quantitative-computed-tomography-derived-thigh-adipose-tissue-subcompartments-in-young-girls-using-a-3-t-mri-scanner
#12
Robert M Blew, Vinson R Lee, Jennifer W Bea, Megan C Hetherington-Rauth, Jean-Phillipe Galons, Maria I Altbach, Timothy G Lohman, Scott B Going
The ability to assess skeletal muscle adipose tissue is important given the negative clinical implications associated with greater fat infiltration of the muscle. Computed tomography and magnetic resonance imaging (MRI) are highly accurate for measuring appendicular soft tissue and muscle composition, but have limitations. Peripheral quantitative computed tomography (pQCT) is an alternative that investigators find valuable because of its low radiation, fast scan time, and comparatively lower costs. The present investigation sought to assess the accuracy of pQCT-derived estimates of total, subcutaneous, skeletal muscle, intermuscular, and calculated intramuscular adipose tissue areas, and muscle density in the midthigh of young girls using the gold standard, 3 T MRI, as the criterion...
March 23, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29703617/hazards-of-improper-dispensary-literature-review-and-report-of-an-accidental-chloroform-injection
#13
Prashant Verma, Patricia Tordik, Ali Nosrat
Several clear, transparent solutions are used in endodontics. Inappropriate dispensing methods can lead to accidental injection or accidental irrigation. These accidents can cause permanent tissue damage including damage to the bone, periodontium, nerves, and vasculature. This article reports on the consequences of an accidental chloroform injection. Nonsurgical retreatment of tooth #8 was planned as part of a restorative treatment plan in a 69-year-old woman. The dentist accidentally injected chloroform instead of local anesthesia because chloroform was loaded into the anesthetic syringe...
April 24, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29703011/desmoplastic-small-round-cell-tumor-of-the-middle-ear-a-case-report
#14
Jing Xu, Mengwei Yao, Xinxin Yang, Tao Liu, Shaohua Wang, Dengdian Ma, Xiaoyu Li
RATIONALE: Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive and malignant tumor. This report describes a case involving DSRCT of the middle ear which no case has been reported in the literature till date. PATIENT CONCERN: A 59-year-old Chinese man with a 40-year history of repeated suppuration of his right ear and 1-year history of drooping of the angle of mouth. The CT of the middle ear and brain scan and enhanced MRI showed space occupying lesion in the right middle ear...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29698293/can-shoulder-muscle-activity-be-evaluated-with-ultrasound-shear-wave-elastography
#15
Kwanwoo Kim, Hyun-Jung Hwang, Seul-Gi Kim, Jin-Hyuck Lee, Woong Kyo Jeong
BACKGROUND: Quantitative assessment of rotator cuff muscle activity is important in the treatment of shoulder disorders. However, the known methods for assessing rotator cuff muscle activity thus far have been inaccurate, invasive, and inconvenient. QUESTIONS/PURPOSES: (1) Does the activity of the deltoid, supraspinatus, and infraspinatus muscles measured using ultrasound shear wave elastography have a linear correlation with muscle activity assessed using generally used methods, including isokinetic dynamometry and electromyography? (2) Does the activity of the deltoid, supraspinatus, and infraspinatus muscles measured using shear wave elastography show good intraobserver and interobserver reliability? METHODS: Twelve volunteers participated in intrasession reliability experiments...
April 24, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29693003/bioaccumulation-of-heavy-metals-in-water-sediments-and-tissues-and-their-histopathological-effects-on-anodonta-cygnea-linea-1876-in-kabul-river-khyber-pakhtunkhwa-pakistan
#16
Muhammad Iftikhar Khan, Muhammad Khisroon, Ajmal Khan, Naila Gulfam, Muhammad Siraj, Farrah Zaidi, Ahmadullah, Abidullah, Syeda Hira Fatima, Shumaila Noreen, Hamidullah, Zafar Ali Shah, Fazli Qadir
The present investigation aimed to assess the concentrations of selected heavy metals in water and sediments and their bioaccumulation in tissues of freshwater mussels and their histopathological effects on the digestive gland, gills, and gonads of Anodonta cygnea . Water, sediments, and freshwater mussel samples were collected at four sites, that is, reference and polluted sites, along the Kabul River, Khyber Pakhtunkhwa. The polluted sites were receiving effluents from the industrial, agricultural, municipal, and domestic sources...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29684623/decoration-of-rgd-mimetic-porous-scaffolds-with-engineered-and-devitalized-extracellular-matrix-for-adipose-tissue-regeneration
#17
Eleonora Rossi, Julien Guerrero, Paola Aprile, Alessandro Tocchio, Elisabeth A Kappos, Cristina Lenardi, Ivan Martin, Arnaud Scherberich
Fat grafting is emerging as a promising alternative to silicon implants in breast reconstruction surgery. Unfortunately, this approach does not provide a proper mechanical support and is affected by drawbacks such as tissue resorption and donor site morbidity. Synthetic scaffolds can offer a valuable alternative to address these challenges, but poorly recapitulate the biochemical stimuli needed for tissue regeneration. Here, we aim at combining the positive features of a structural, synthetic polymer to an engineered, devitalized extracellular matrix (ECM) to generate a hybrid construct that can provide a mix of structural and biological stimuli needed for adipose tissue regeneration...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29675364/ct-and-mri-of-superficial-solid-tumors
#18
REVIEW
Jingfeng Zhang, Yanyuan Li, Yilei Zhao, Jianjun Qiao
Superficial solid masses are common conditions in clinical practice, however, some of which can be easily diagnosed and others would be difficult. Although imaging of superficial masses is not always characteristic, it would be helpful to give a definitive diagnosis or narrow a differential diagnosis. Crossing-section imaging can depicture the masses directly, find some pathognomonic signs and demonstrate their relationship with adjacent structures, which can provide decision support for clinician's reference...
March 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29663492/efficacy-of-epinephrine-free-articaine-compared-to-articaine-with-epinephrine-1-100-000-for-maxillary-infiltration-a-randomized-clinical-trial
#19
Konstantinos Paterakis, Marc Schmitter, Sareh Said Yekta-Michael
OBJECTIVE: The selection of local anesthetic in dental practice is essential to the patient's comfort and the success of the treatment. Many patients prefer anesthesia even for short treatments. Articaine is a local anesthetic commonly used for dental practice. The duration of the effect of articaine on the nerve fibers is not yet precisely reported. This study was aimed to evaluate the clinical efficacy of 4% articaine with and without epinephrine in treatment of occlusal caries. MATERIALS AND METHODS: Thirty healthy patients were included in this randomized double-blind study...
April 16, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29661929/arginase-1-expression-in-myeloid-cells-regulates-s-aureus-planktonic-but-not-biofilm-infection
#20
Kelsey J Yamada, Cortney E Heim, Amy L Aldrich, Casey M Gries, Anna G Staudacher, Tammy Kielian
S. aureus is a leading cause of device-associated biofilm infections, which represent a serious health care concern based on their chronicity and antibiotic resistance. We previously reported that S. aureus biofilms preferentially recruit myeloid-derived suppressor cells (MDSCs), which promote monocyte and macrophage anti-inflammatory properties. This is associated with increased myeloid arginase-1 (Arg-1) expression, which has been linked to anti-inflammatory and pro-fibrotic activity that are observed during S...
April 16, 2018: Infection and Immunity
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