Hackwon Do, Zhong-Rui Li, Praveen Kumar Tripathi, Sonali Mitra, Stephanie Guerra, Ananya Dash, Dulanthi Weerasekera, Nishanth Makthal, Syed Shams, Shifu Aggarwal, Bharat Bhushan Singh, Di Gu, Yongle Du, Randall J Olsen, Christopher LaRock, Wenjun Zhang, Muthiah Kumaraswami
Probiotic supplements are suggested to promote human health by preventing pathogen colonization. However, the mechanistic bases for their efficacy in vivo are largely uncharacterized. Here using metabolomics and bacterial genetics, we show that the human oral probiotic Streptococcus salivarius K12 (SAL) produces salivabactin, an antibiotic that effectively inhibits pathogenic Streptococcus pyogenes (GAS) in vitro and in mice. However, prophylactic dosing with SAL enhanced GAS colonization in mice and ex vivo in human saliva...
January 16, 2024: Nature Microbiology