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https://www.readbyqxmd.com/read/29621734/protective-effect-of-pristimerin-against-lps-induced-acute-lung-injury-in-mice
#1
Ahmed A Shaaban, Dalia H El-Kashef, Mohamed F Hamed, Dina S El-Agamy
Pristimerin (Pris) is a triterpenoid derivative obtained from Celastraceae and Hippocrateaceae families. This compound has been extensively tested for its potent anti-cancer activity against different types of tumors. However, its effects against acute lung injury (ALI) remain to be investigated. This study explored the efficacy of Pris to protect against lipopolysaccharide (LPS)-induced ALI and its possible pathways. Results have shown that Pris possesses potent protective activity against LPS-induced acute lung damage...
April 2, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29621137/trap1-regulation-of-cancer-metabolism-dual-role-as-oncogene-or-tumor-suppressor
#2
REVIEW
Danilo Swann Matassa, Ilenia Agliarulo, Rosario Avolio, Matteo Landriscina, Franca Esposito
Metabolic reprogramming is an important issue in tumor biology. An unexpected inter- and intra-tumor metabolic heterogeneity has been strictly correlated to tumor outcome. Tumor Necrosis Factor Receptor-Associated Protein 1 (TRAP1) is a molecular chaperone involved in the regulation of energetic metabolism in cancer cells. This protein is highly expressed in several cancers, such as glioblastoma, colon, breast, prostate and lung cancers and is often associated with drug resistance. However, TRAP1 is also downregulated in specific tumors, such as ovarian, bladder and renal cancers, where its lower expression is correlated with the worst prognoses and chemoresistance...
April 5, 2018: Genes
https://www.readbyqxmd.com/read/29619118/epigenetic-modifications-in-kdm-lysine-demethylases-associate-with-survival-of-early-stage-nsclc
#3
Yongyue Wei, Junya Liang, Ruyang Zhang, Yichen Guo, Sipeng Shen, Li Su, Xihong Lin, Sebastian Moran, Åslaug Helland, Maria M Bjaanæs, Anna Karlsson, Maria Planck, Manel Esteller, Thomas Fleischer, Johan Staaf, Yang Zhao, Feng Chen, David C Christiani
Background: KDM lysine demethylase family members are related to lung cancer clinical outcomes and are potential biomarkers for chemotherapeutics. However, little is known about epigenetic alterations in KDM genes and their roles in lung cancer survival. Methods: Tumor tissue samples of 1230 early-stage non-small cell lung cancer (NSCLC) patients were collected from the five independent cohorts. The 393 methylation sites in KDM genes were extracted from epigenome-wide datasets and analyzed by weighted random forest (Ranger) in discovery phase and validation dataset, respectively...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29617184/targeting-interleukin-22-for-cancer-therapy
#4
Anamarija Markota, Stefan Endres, Sebastian Kobold
Interleukin-22 (IL-22) is a member of IL-10 family of cytokines. IL-22 induces proliferative and anti-apoptotic signaling pathways and production of anti-microbial molecules that enhance tissue regeneration and host defense. IL-22 has also been identified as a cancer-promoting cytokine since deregulation of the IL-22-IL-22R1 system is linked to different cancer entities including lung, breast, gastric, pancreatic and colon cancers. T cells and innate lymphoid cells are the main cellular sources of IL-22. Expression of its specific receptor IL-22R1 is restricted to the non-hematopoietic cells which makes the IL-22-IL-22R1 pathway an attractive target for anti-cancer therapy...
April 4, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29616096/a-comprehensive-analysis-of-the-predicted-targets-of-mir-642b-3p-associated-with-the-long-non-coding-rna-hoxa11-as-in-nsclc-cells
#5
Yu Zhang, Jie Luo, Xiao Wang, Han-Lin Wang, Xiu-Ling Zhang, Ting-Qing Gan, Gang Chen, Dian-Zhong Luo
Long non-coding RNA HOXA11 antisense RNA (HOXA11-AS) has been previously reported to be involved in the tumorigenesis and progression of ovarian cancer and glioma. However, the function of HOXA11-AS in lung cancer remains unclear. Following the knockdown of HOXA11-AS in A549 cells, a microarray analysis was performed in order to detect the differences in microRNA (miRNA/miR) profiles. Subsequently, miR-642b-3p was selected for further analysis. Four miRNA target prediction algorithms were used to identify potential target genes of miR-642b-3p...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29607329/prognostic-roles-of-mrna-expression-of-s100-in-non-small-cell-lung-cancer
#6
Ying Liu, Jian Cui, Yun-Liang Tang, Liang Huang, Cong-Yang Zhou, Ji-Xiong Xu
The S100 protein family is involved in cancer cell invasion and metastasis, but its prognostic value in non-small-cell lung cancer (NSCLC) has not been elucidated. In the present study we investigated the prognostic role of mRNA expression of each individual S100 in NSCLC patients through the Kaplan-Meier plotter (KM plotter) database. Expression of 14 members of the S100 family correlated with overall survival (OS) for all NSCLC patients; 18 members were associated with OS in adenocarcinoma, but none were associated with OS in squamous cell carcinoma...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29606701/rbl2-p130-is-a-direct-akt-target-and-is-required-to-induce-apoptosis-upon-akt-inhibition-in-lung-cancer-and-mesothelioma-cell-lines
#7
Francesca Pentimalli, Iris M Forte, Luca Esposito, Paola Indovina, Carmelina A Iannuzzi, Luigi Alfano, Caterina Costa, Daniela Barone, Gaetano Rocco, Antonio Giordano
The retinoblastoma (RB) protein family includes RB1/p105, RBL1/p107, and RBL2/p130, which are key factors in cell-cycle regulation and stand at the crossroads of multiple pathways dictating cell fate decisions. The role of RB proteins in apoptosis is controversial because they can inhibit or promote apoptosis depending on the context, on the apoptotic stimuli and on their intrinsic status, impacting on the response to antitumoral treatments. Here we identified RBL2/p130 as a direct substrate of the AKT kinase, a key antiapoptotic factor hyperactive in multiple cancer types...
April 2, 2018: Oncogene
https://www.readbyqxmd.com/read/29604204/kallikrein-related-peptidases-in-lung-diseases
#8
Woodys Lenga Ma Bonda, Sophie Iochmann, Mélia Magnen, Yves Courty, Pascale Reverdiau
Human tissue kallikreins (KLKs) are 15 members of the serine protease family and are present in various healthy human tissues including airway tissues. Multiple studies have revealed their crucial role in the pathophysiology of a number of chronic, infectious and tumour lung diseases. KLK1, 3 and 14 are involved in asthma pathogenesis, and KLK1 could be also associated with the exacerbation of this inflammatory disease caused by rhinovirus. KLK5 was demonstrated as an influenza virus activating protease in humans, and KLK1 and 12 could also be involved in the activation and spread of these viruses...
March 1, 2018: Biological Chemistry
https://www.readbyqxmd.com/read/29594059/severe-inflammatory-ophthalmopathy-in-a-euthyroid-patient-during-nivolumab-treatment
#9
Pauline Campredon, Philippe Imbert, Céline Mouly, Solange Grunenwald, Julien Mazières, Philippe Caron
Introduction: Nivolumab is a promising treatment in patients with advanced malignancies. Among immune-related adverse events, autoimmune thyroid disorders are frequently reported. Patient: A 61-year-old male patient had no history of familial or personal thyroid disease. In 2012, this patient, a heavy smoker, presented with non-small-cell lung cancer that was treated with radiotherapy and chemotherapy. In 2015, the cancer progressed with cervical compressive symptoms, and the patient was treated with nivolumab...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29593668/simulation-study-of-cdna-dataset-to-investigate-possible-association-of-differentially-expressed-genes-of-human-thp1-monocytic-cells-in-cancer-progression-affected-by-bacterial-shiga-toxins
#10
Syed A Muhammad, Jinlei Guo, Thanh M Nguyen, Xiaogang Wu, Baogang Bai, X Frank Yang, Jake Y Chen
Shiga toxin (Stxs) is a family of structurally and functionally related bacterial cytotoxins produced by Shigella dysenteriae serotype 1 and shigatoxigenic group of Escherichia coli that cause shigellosis and hemorrhagic colitis, respectively. Until recently, it has been thought that Stxs only inhibits the protein synthesis and induces expression to a limited number of genes in host cells, but recent data showed that Stxs can trigger several signaling pathways in mammalian cells and activate cell cycle and apoptosis...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29587666/cost-effectiveness-analysis-of-afatinib-versus-pemetrexed-cisplatin-for-first-line-treatment-of-locally-advanced-or-metastatic-egfr-mutation-positive-non-small-cell-lung-cancer-from-the-singapore-healthcare-payer-s-perspective
#11
Ping-Tee Tan, Mohamed Ismail Abdul Aziz, Fiona Pearce, Wan-Teck Lim, David Bin-Chia Wu, Kwong Ng
BACKGROUND: Non-small-cell lung cancer (NSCLC) accounts for 85% of all lung cancers and is associated with a poor prognosis. Afatinib is an irreversible ErbB family blocker recommended in clinical guidelines as a first-line treatment for NSCLC which harbours an epidermal growth factor receptor (EGFR) mutation. The objective of this study was to evaluate the cost-effectiveness of afatinib versus pemetrexed-cisplatin for first-line treatment of locally advanced or metastatic EGFR mutation positive NSCLC in Singapore...
March 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29587605/chondritis-of-the-ear-after-docetaxel-carboplatin-chemotherapy
#12
Tae Hoon Kong, Sung Min Han, Young Joon Seo
Docetaxel, derived from the yew tree, belongs to the taxane family of medications. It works by disrupting the normal function of microtubules, thereby stopping cell division. Docetaxel is used in the treatment of ovarian, breast, esophageal, gastric, prostate, lung, and head and neck cancers. Common side effects include hair loss, low blood cell counts, peripheral neuropathy, vomiting, and muscle pain. Auricular chondritis with ear deformity has not been reported previously as a side effect of docetaxel. In this paper, we present the case of a 64-year-old male patient with chondritis accompanied by ear deformity that developed due to docetaxel-carboplatin chemotherapy for non-small cell lung cancer...
January 1, 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29581961/hospitalization-trends-in-adult-patients-with-copd-and-other-respiratory-diseases-in-northeast-china-from-2005-to-2015
#13
Honglei Liu, Ni Wang, Wei Chen, Wenyan Liu, Shiping Wang, Jianbo Lei, Hui Chen
Chronic obstructive pulmonary disease (COPD), pneumonia, asthma, and lung cancer are four common respiratory diseases that impose a substantial economic burden on both patients and government in China. The objective of our study is to analyze the temporal trends of several clinical tracking metrics for hospitalization regarding these diseases. Hospital discharge data of 54 hospitals for the period 2005-2015 were derived from the Health and Family Planning Commission in Northeast China. The age-adjusted rate of discharge for the four respiratory diseases increased significantly (COPD, pneumonia, asthma: P trend <  ...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29581829/cystatin-a-suppresses-tumor-cell-growth-through-inhibiting-epithelial-to-mesenchymal-transition-in-human-lung-cancer
#14
Yunxia Ma, Yuan Chen, Yong Li, Katja Grün, Alexander Berndt, Zhongwei Zhou, Iver Petersen
Cystatin A ( CSTA ), belonging to type 1 cystatin super-family, is expressed primarily in epithelial and lymphoid tissues for protecting cells from proteolysis of cytoplasmic and cytoskeletal proteins by cathepsins B, H and L. CSTA acts as a tumor suppressor in esophageal cancer, however, its role in lung cancer has not yet been elucidated. Here we found that CSTA was down-regulated in all lung cancer cell lines compared to normal lung epithelial cells. CSTA was restored in most lung cancer cell lines after treatment with demethylation agent 5-aza-2-deoxycytidine and deacetylation agent Trichostatin...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29580806/targeting-the-nrf-2-rhoa-rock-signaling-pathway-with-a-novel-aziridonin-yd0514-to-suppress-breast-cancer-progression-and-lung-metastasis
#15
Dengfeng Li, Hong Wang, Ye Ding, Ziwei Zhang, Zhi Zheng, Jiabin Dong, Hyejin Kim, Xiaojing Meng, Qianjun Zhou, Jia Zhou, Lin Fang, Qiang Shen
Metastasis is a major cause of breast cancer-associated mortality. Natural products extracted from herbs provide rich bioactive compounds with anticancer efficacy but may have limited or moderate potency and considerable toxicity. We developed a novel aziridonin, YD0514, by aziridinating oridonin, a natural product of the medicinal herb Rabdosia rubescens. In this study, we found that YD0514 significantly inhibited proliferation, motility, and adhesion of metastatic breast cancer cell lines MDA-MB-231, GI101, GILM2, and GILM3...
March 23, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29576497/urine-proteome-profiling-predicts-lung-cancer-from-control-cases-and-other-tumors
#16
Chunchao Zhang, Wenchuan Leng, Changqing Sun, Tianyuan Lu, Zhengang Chen, Xuebo Men, Yi Wang, Guangshun Wang, Bei Zhen, Jun Qin
Development of noninvasive, reliable biomarkers for lung cancer diagnosis has many clinical benefits knowing that most of lung cancer patients are diagnosed at the late stage. For this purpose, we conducted proteomic analyses of 231 human urine samples in healthy individuals (n=33), benign pulmonary diseases (n=40), lung cancer (n=33), bladder cancer (n=17), cervical cancer (n=25), colorectal cancer (n=22), esophageal cancer (n=14), and gastric cancer (n=47) patients collected from multiple medical centers...
March 17, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29574020/sirt1-and-micrornas-the-role-in-breast-lung-and-prostate-cancers
#17
REVIEW
Hedyieh Karbasforooshan, Ali Roohbakhsh, Gholamreza Karimi
Breast cancer and prostate cancer are the most common malignant tumors in female and men, respectively. Furthermore, lung cancer is the leading cause of cancer deaths worldwide. It is an emergency to develop a powerful strategy to treat these threatening cancers more effectively, because of low efficacy and high rates of chemotherapy effects. MicroRNAs (miRNAs), a class of small non-coding RNAs, are key regulators of gene expression via induction of translational repression or mRNA degradation. MiRNA deregulation has been linked to cancer initiation and progression...
March 21, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29570945/diagnostic-and-prognostic-value-of-serum-cripto-1-in-patients-with-non-small-cell-lung-cancer
#18
Chun Hua Xu, Chuan Zhen Chi, Qian Zhang, Yu Chao Wang, Wei Wang, Qi Yuan, Ping Zhan, Xiu Wei Zhang, Yong Lin
INTRODUCTION: Cripto-1 (CR-1) is a member of the epidermal growth factor (EGF)-CFC protein family, which is involved in tumor pathogenesis. OBJECTIVES: This study aimed to explore the diagnostic and prognostic value of serum CR-1 level in patients with non-small cell lung cancer (NSCLC). METHOD: Serum specimens from 312 NSCLC patients and 120 healthy controls were collected. Serum CR-1 level was measured using enzyme-linked immunosorbent assay (ELISA)...
March 23, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29568882/long-non-coding-rnas-rp5-821d11-7-apcdd1l-as1-and-rp11-277p12-9-were-associated-with-the-prognosis-of-lung-squamous-cell-carcinoma
#19
Yanzhuo Luo, Zhaobo Xuan, Xiaofeng Zhu, Peng Zhan, Zhou Wang
Lung squamous cell carcinoma (LUSC), a type of non-small cell lung carcinoma, has a poor therapeutic response, high relapse rate and poor prognosis. The present study was designed to reveal the key long non‑coding RNAs (lncRNAs) associated with the prognosis of LUSC. The lncRNA expression profiles of LUSC and adjacent samples were downloaded from The Cancer Genome Atlas database. Based on the edgeR and DEseq packages, the differentially expressed lncRNAs (DELs) between LUSC and adjacent samples were obtained and the intersecting DELs were regarded as significant DELs...
March 16, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29567880/myeloid-cell-leukemia-1-protein-expression-and-myeloid-cell-leukemia-1-gene-amplification-in-non-small-cell-lung-cancer
#20
Tony El Jabbour, Siddhartha Dilip Dalvi, Sungeun Kim, Christine Sheehan, Jeffrey S Ross
Background: Myeloid cell leukemia-1 (Mcl-1) is a member of the B-cell lymphoma 2 family known to play a significant role in the regulation of apoptosis. Mcl-1 expression has been studied in nonsmall cell lung cancer (NSCLC) cell lines but has not been previously evaluated as a prognostic factor in clinical samples. Materials and Methods: Formalin-fixed, paraffin-embedded sections from 119 NSCLC, including 33 squamous cell carcinomas (SCC), 55 adenocarcinomas (AC), and 31 either pure adenocarcinoma in situ (AIS) or AC with lepidic features were immunostained by an automated method with rabbit polyclonal Mcl-1...
January 2018: Indian Journal of Pathology & Microbiology
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