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T2-mapping

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https://www.readbyqxmd.com/read/29343659/cardiac-mr-imaging-of-hypertrophic-cardiomyopathy-techniques-findings-and-clinical-relevance
#1
Yasuo Amano, Mitsunobu Kitamura, Hitoshi Takano, Fumi Yanagisawa, Masaki Tachi, Yasuyuki Suzuki, Shinichiro Kumita, Morimasa Takayama
Hypertrophic cardiomyopathy (HCM) is a relatively common myocardial genetic disease having a wide variety of symptoms and prognoses. The most serious complications of HCM are sudden cardiac death induced by ventricular arrhythmia or inappropriate changes in blood pressure, and heart failure. Cardiac MR imaging is a valuable imaging method for detecting HCM because of its accurate measurement of wall thickness and myocardial mass without limited view and the unique ability of late gadolinium enhancement (LGE) to identify myocardial fibrosis related to the prognosis of HCM...
January 18, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29339314/surface-based-characteristics-of-the-cerebellar-cortex-visualized-with-ultra-high-field-mri
#2
Yohan Boillat, Pierre-Louis Bazin, Kieran O'Brien, Mário João Fartaria, Guillaume Bonnier, Gunnar Krueger, Wietske Van der Zwaag, Cristina Granziera
Although having a relatively homogeneous cytoarchitectonic organization, the cerebellar cortex is a heterogeneous region characterized by different amounts of myelin, iron and protein expression profiles. In this study, we used quantitative T1 and T2* mapping at ultra-high field (7T) MRI to investigate the tissue characteristics of the cerebellar gray matter surface and its layers. Detailed subject-specific surfaces were generated at three different cortical depths and averaged across subjects to create averaged T1 and T2* maps on the cerebellar surface...
January 12, 2018: NeuroImage
https://www.readbyqxmd.com/read/29322233/high-isotropic-resolution-t2-mapping-of-the-lumbosacral-plexus-with-t2-prepared-3d-turbo-spin-echo
#3
Nico Sollmann, Dominik Weidlich, Barbara Cervantes, Elisabeth Klupp, Carl Ganter, Hendrik Kooijman, Ernst J Rummeny, Claus Zimmer, Jan S Kirschke, Dimitrios C Karampinos
PURPOSE: Isotropic high-resolution three-dimensional (3D) magnetic resonance neurography (MRN) is increasingly used to depict even small and highly oblique nerves of the lumbosacral plexus (LSP). The present study introduces a T2 mapping sequence (T2-prepared 3D turbo spin echo) that is B1-insensitive and enables quantitative assessment of LSP nerves. METHODS: In this study 15 healthy subjects (mean age 28.5 ± 3.8 years) underwent 3 T MRN of the LSP area three times...
January 10, 2018: Clinical Neuroradiology
https://www.readbyqxmd.com/read/29318429/effect-of-intra-articular-injection-of-intermediate-weight-hyaluronic-acid-on-hip-and-knee-cartilage-in-vivo-evaluation-using-t2-mapping
#4
Giulio Ferrero, Luca Maria Sconfienza, Francesco Fiz, Emanuele Fabbro, Angelo Corazza, Daniele Dettore, Davide Orlandi, Carlo Castellazzo, Stefano Tornago, Giovanni Serafini
OBJECTIVES: We used T2 mapping to quantify the effect of intra-articular hyaluronic acid administration (IAHAA) on cartilage with correlation to clinical symptoms. METHODS: One hundred two patients with clinical and MRI diagnosis of hip or knee grade I-III chondropathy were prospectively included. All patients received a standard MRI examination of the affected hip/knee (one joint/patient) and T2-mapping multiecho sequence for cartilage evaluation. T2 values of all slices were averaged and used for analysis...
January 9, 2018: European Radiology
https://www.readbyqxmd.com/read/29288037/simulation-based-quantification-of-native-t1-and-t2-of-the-myocardium-using-a-modified-molli-scheme-and-the-importance-of-magnetization-transfer
#5
Christos G Xanthis, Sebastian Bidhult, Andreas Greiser, Kelvin Chow, Richard B Thompson, Håkan Arheden, Anthony H Aletras
Quantitative cardiovascular Magnetic Resonance Imaging techniques are gaining wide acceptance within the MR community due to their potential to diagnose non-localized disease, guide therapy and improve patient outcome. During the last decade, there has been an increasing interest for developing new techniques that allow for simultaneous quantification of both T1 and T2 maps of myocardium. Newer studies demonstrated that the incorporation of MRI simulations could yield similar results to conventional mapping techniques in the myocardium...
December 26, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29285782/hyperpolarized-13-c-15-n2-urea-t2-relaxation-changes-in-acute-kidney-injury
#6
Christian Østergaard Mariager, Per Mose Nielsen, Haiyun Qi, Steffen Ringgaard, Christoffer Laustsen
PURPOSE: To investigate the correlation between renal ischemia and 13 C-urea T2 relaxation rate in an acute kidney injury (AKI) rat model. METHODS: Six rats subjected to unilateral renal ischemia were investigated. Creatinine clearance, urine output, plasma creatinine as well as blood-urea nitrogen (BUN) values were acquired before and after the procedure. 1 H T2* mapping was acquired using blood oxygenation level dependent (BOLD) MRI and hyperpolarized 13 C-urea T2 mapping was acquired using a 2D golden-angle radial approach...
December 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29261532/t2-mapping-for-noninvasive-assessment-of-interstitial-edema-in-acute-cardiac-allograft-rejection-in-a-mouse-model-of-heterotopic-heart-transplantation
#7
Dagmar Hartung, Katja Hueper, Rongjun Chen, Marcel Gutberlet, Frank Wacker, Martin Meier, Song Rong, Mi-Sun Jang, Jan H Bräsen, Faikah Gueler
OBJECTIVES: Heart transplantation (HTX) in mice is used to characterize gene-deficient mice and to test new treatment strategies. The purpose was to establish noninvasive magnetic resonance imaging techniques in mice to monitor pathophysiological changes of the allograft during rejection. MATERIALS AND METHODS: Magnetic resonance imaging was performed at baseline and days 1 and 6 after isogenic (n = 10, C57BL/6) and allogenic (n = 12, C57BL/6 to BALB/c) heterotopic HTX on a 7 T small animal scanner...
December 19, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29251760/quantitative-oedema-analysis-using-cardiac-magnetic-resonance-t2-mapping-techniques-in-diagnosis-of-takotsubo-cardiomyopathy
#8
Barbara Miłosz-Wieczorek, Mariusz Kłopotowski, Agata Kubik, Magdalena Marczak, Mateusz Śpiewak
No abstract text is available yet for this article.
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29242240/persistence-of-infarct-zone-t2-hyperintensity-at-6-months-after-acute-st-segment-elevation-myocardial-infarction-incidence-pathophysiology-and-prognostic-implications
#9
Jaclyn Carberry, David Carrick, Caroline Haig, Nadeem Ahmed, Ify Mordi, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Stuart Hood, Stuart Watkins, Mitchell Lindsay, Andrew Davie, Ahmed Mahrous, Ian Ford, Naveed Sattar, Paul Welsh, Aleksandra Radjenovic, Keith G Oldroyd, Colin Berry
BACKGROUND: The incidence and clinical significance of persistent T2 hyperintensity after acute ST-segment-elevation myocardial infarction (STEMI) is uncertain. METHODS AND RESULTS: Patients who sustained an acute STEMI were enrolled in a cohort study (BHF MR-MI: NCT02072850). Two hundred eighty-three STEMI patients (mean age, 59±12 years; 75% male) had cardiac magnetic resonance with T2 mapping performed at 2 days and 6 months post-STEMI. Persisting T2 hyperintensity was defined as infarct T2 >2 SDs from remote T2 at 6 months...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29237044/comparison-of-molli-shmollli-and-sasha-in-discrimination-between-health-and-disease-and-relationship-with-histologically-derived-collagen-volume-fraction
#10
Nicholas Child, Gonca Suna, Darius Dabir, May-Lin Yap, Toby Rogers, Misha Kathirgamanathan, Eduardo Arroyo-Ucar, Rocio Hinojar, Islam Mahmoud, Christopher Young, Olaf Wendler, Manuel Mayr, Banher Sandhu, Geraint Morton, Marion Muhly-Reinholz, Stefanie Dimmeler, Eike Nagel, Valentina O Puntmann
Aims: To determine the bioequivalence of several T1 mapping sequences in myocardial characterization of diffuse myocardial fibrosis. Methods and results: We performed an intra-individual sequence comparison of three types of T1 mapping sequences [MOdified Look-Locker Inversion recovery (MOLLI), Shortened MOdified Look-Locker Inversion recovery ((sh)MOLLI), and SAturation recovery single-SHot Acquisition (SASHA)]. We employed two model diseases of diffuse interstitial fibrosis [patients with non-ischaemic dilated cardiomyopathy (NIDCM), n = 32] and aortic stenosis [(AS), n = 25)]...
December 11, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29231349/-effect-of-ear-point-embedding-on-plasma-and-effect-site-concentrations-of-propofol-remifentanil-in-elderly-patients-after-target-controlled-induction
#11
Xiaochun Zheng, Liling Wan, Fei Gao, Jianghu Chen, Wenshao Tu
OBJECTIVE: To observe the clinical effect of ear point embedding on plasma and effect site concentrations of propofol-remifentanil in elderly patients who underwent abdominal external hernia surgery at the time of consciousness and pain disappearing by target-controlled infusion (TCI) and bispectral index (BIS). METHODS: Fifty patients who underwent elective abdominal hernia surgery were randomly assigned into an observation group and a control group, 25 cases in each one...
August 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29219019/quantitative-mri-of-human-cartilage-in-vivo-relationships-with-arthroscopic-indentation-stiffness-and-defect-severity
#12
Tuomas Svärd, Martti Lakovaara, Harri Pakarinen, Marianne Haapea, Ilkka Kiviranta, Eveliina Lammentausta, Jukka Jurvelin, Osmo Tervonen, Risto Ojala, Miika Nieminen
Objective To investigate the association of cartilage defect severity, as determined by the International Cartilage Repair Society (ICRS) grading with indentation stiffness and T2 relaxation time of magnetic resonance imaging (MRI), a biomarker for the integrity of articular cartilage. Design Twenty-one patients scheduled for arthroscopic were included in the study. Prior to arthroscopy, subjects underwent quantitative MRI of articular cartilage, namely T2 relaxation time mapping at 1.5 T. Within 2 months, subjects underwent arthroscopy, which also included ICRS grading and measurement of arthroscopic indentation stiffness...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29208853/investigations-of-cartilage-matrix-degeneration-in-patients-with-early-stage-femoral-head-necrosis
#13
Ronghua Xu, Bo Wei, Jiayi Li, Chenyu Huang, Rongcai Lin, Cheng Tang, Yan Xu, Qingqiang Yao, Liming Wang
BACKGROUND The purpose of this study was to explore changes in cartilage matrix in early-stage femoral head necrosis (FHN). MATERIAL AND METHODS Femoral head samples of patients with early FHN were collected during total hip arthroplasty (THA), high-field 7.0T MRI scans were performed in vitro, and the average T2 values were calculated. Cartilage samples were obtained from the weight-bearing area (FHN group) and non-weight-bearing area (Control group), divided into 3 equal parts and used for biochemical analysis, histopathological staining, and gene expression analysis...
December 6, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29204454/magnetic-resonance-imaging-for-patellofemoral-chondromalacia-is-there-a-role-for-t2-mapping
#14
Carola F van Eck, R Scott Kingston, John V Crues, F Daniel Kharrazi
Background: Patellofemoral pain is common, and treatment is guided by the presence and grade of chondromalacia. Purpose: To evaluate and compare the sensitivity and specificity in detecting and grading chondral abnormalities of the patella between proton density fat suppression (PDFS) and T2 mapping magnetic resonance imaging (MRI). Study Design: Cohort study; Level of evidence, 2. Methods: A total of 25 patients who underwent MRI of the knee with both a PDFS sequence and T2 mapping and subsequently underwent arthroscopic knee surgery were included...
November 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29202992/beneficial-clinical-effects-but-limited-tissue-quality-following-osteochondral-repair-with-a-cell-free-multilayered-nano-composite-scaffold-in-the-talus
#15
Martin Kaipel, Markus Schreiner, Richard Kellner, Joachim Klikovits, Sebastian Apprich, Martin Brix, Harald Boszotta, Stephan Domayer, Siegfried Trattnig
BACKGROUND: The treatment of larger osteochondral lesions of the talus remains an operative challenge. In addition to micro fracturing and osteochondral transplantation one promising strategy could be the operative repair with a cell-free multilayered nano-composite scaffold with the potential to regenerate bone and cartilage in one treatment. METHODS: In this prospective case series four consecutive patients who suffered from a single osteochondral lesion (≥1...
December 2017: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29202501/assessment-of-t2-relaxation-times-for-normal-canine-knee-articular-cartilage-by-t2-mapping-using-1-5-t-magnetic-resonance-imaging
#16
Asami Matsui, Miki Shimizu, Brian Beale, Fumitaka Takahashi, Sinya Yamaguchi
Objectives This study aims to assess and compare the T2 relaxation times for articular cartilage of normal canine stifle joints in four regions by T2 mapping using a 1.5-T magnetic resonance imaging (MRI). Methods In vivo prospective study: 20 hindlimbs (left and right) from 10 normal healthy beagle dogs (n = 20). The region of interest (ROI) was subdivided into medial and lateral condyles of femoral cartilage (MF and LF, respectively) and medial and lateral condyles of tibial cartilage (MT and LT, respectively)...
November 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/29201194/protective-effect-of-zoledronic-acid-on-articular-cartilage-and-subchondral-bone-of-rabbits-with-experimental-knee-osteoarthritis
#17
Guorong She, Ziqi Zhou, Zhengang Zha, Fei Wang, Xiaoting Pan
Subchondral bone reabsorption and remodeling are responsible for the initiation and progression of osteoarthritis (OA). Zoledronic acid (ZOL), a third-generation bisphosphonate (BIS), is an inhibitor of bone reabsorption. However, the intervention effect of ZOL on OA has not been fully characterized and remains to be directly demonstrated in animal experiments. The present study examined the microscopic and macroscopic changes in the anterior cruciate ligament transection (ACLT) model of OA in rabbits and evaluated the effects of ZOL on cartilage degeneration and subchondral bone loss...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29197695/probing-numerical-laplace-inversion-methods-for-two-and-three-site-molecular-exchange-between-interconnected-pore-structures
#18
Emilia V Silletta, María B Franzoni, Gustavo A Monti, Rodolfo H Acosta
Two-dimension (2D) Nuclear Magnetic Resonance relaxometry experiments are a powerful tool extensively used to probe the interaction among different pore structures, mostly in inorganic systems. The analysis of the collected experimental data generally consists of a 2D numerical inversion of time-domain data where T2-T2 maps are generated. Through the years, different algorithms for the numerical inversion have been proposed. In this paper, two different algorithms for numerical inversion are tested and compared under different conditions of exchange dynamics; the method based on Butler-Reeds-Dawson (BRD) algorithm and the fast-iterative shrinkage-thresholding algorithm (FISTA) method...
November 30, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29196823/quantitative-mapping-of-glenohumeral-cartilage-in-asymptomatic-subjects-using-3%C3%A2-t-magnetic-resonance-imaging
#19
Carly A Lockard, Katharine J Wilson, Charles P Ho, Richard C Shin, J Christoph Katthagen, Peter J Millett
OBJECTIVE: The purpose of this study was to develop quantitative T2 mapping methodology in asymptomatic shoulders for the entire mappable region of the glenohumeral cartilage in the coronal and sagittal planes, to assess the feasibility and limitations of the development of a diagnostic tool for future application in symptomatic patients. MATERIALS AND METHODS: Twenty-one asymptomatic volunteers underwent sagittal and coronal glenohumeral T2 mapping, as the spherical geometry of the humeral head obviates the need to evaluate the entire glenohumeral cartilage in a single plane...
December 1, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29174413/mri-measured-myocardial-iron-load-in-patients-with-severe-diabetic-heart-failure
#20
B Wang, Y Zhang, N Sun, S Gu, F Ding, S Xu, H Zhou, Y Liu
AIM: To investigate whether a correlation exists between abnormal myocardial iron status and cardiac lipid deposition as well as other biomarkers in patients with diabetic heart failure (DHF). MATERIALS AND METHODS: Seventeen volunteers (Group 1), 26 patients with non-severe DHF (Group 2), and 25 patients with severe DHF (Group 3) were recruited for this study. Myocardial middle-section T2* mapping and septal 1H magnetic resonance spectroscopy (1H-MRS) were performed using a 3 T magnetic resonance imaging (MRI) machine to assess the iron status and lipid deposition individually...
November 22, 2017: Clinical Radiology
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