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T2-mapping

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https://www.readbyqxmd.com/read/28329275/tissue-characterization-by-t1-and-t2-mapping-cardiovascular-magnetic-resonance-imaging-to-monitor-myocardial-inflammation-in-healing-myocarditis
#1
S Bohnen, U K Radunski, G K Lund, F Ojeda, Y Looft, M Senel, L Radziwolek, M Avanesov, E Tahir, C Stehning, B Schnackenburg, G Adam, S Blankenberg, K Muellerleile
Aims: Monitoring disease activity in myocarditis is important for tailored therapeutic strategies. This study evaluated the ability of T1 and T2 mapping cardiovascular magnetic resonance (CMR) to monitor the course of myocardial inflammation in healing myocarditis. Methods and results: Forty-eight patients with strictly defined acute myocarditis underwent CMR at 1.5 T in the acute stage, at 3-months (n = 39), and at 12-months follow-up (FU) (n = 21). Normal values were obtained in a control group of 27 healthy subjects...
March 8, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28317398/cardiac-transplantation-towards-a-new-noninvasive-approach-of-cardiac-allograft-rejection
#2
Sophie I Mavrogeni, George Athanasopoulos, Aggeliki Gouziouta, Evangelos Leontiadis, Stamatis Adamopoulos, Genovefa Kolovou
Cardiac allograft rejection (CAR) may occur after transplantation and remains silent, until hemodynamic deterioration takes place. Endomyocardial biopsy (EMB) is applied to early detect CAR. Although, flexible bioptoms have decreased the incidence of lethal complications, EMB remains an invasive procedure carrying risk of tamponade and permanent heart block. Therefore, a new non-invasive approach is needed. Areas covered: AlloMap molecular expression testing and graft-derived cell-free DNA (GcfDNA) test can be used as blood indices of acute and chronic CAR, respectively...
March 21, 2017: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/28301205/intratendon-delivery-of-leukocyte-poor-platelet-rich-plasma-improves-healing-compared-with-leukocyte-rich-platelet-rich-plasma-in-a-rabbit-achilles-tendinopathy-model
#3
Ruijian Yan, Yanjia Gu, Jisheng Ran, Yejun Hu, Zefeng Zheng, Mengfeng Zeng, Boonchin Heng, Xiao Chen, Zi Yin, Weishan Chen, Weiliang Shen, Hongwei Ouyang
BACKGROUND: Chronic tendinopathy is a commonly occurring clinical problem that affects both athletes and inactive middle-aged patients. Although some studies have shown that different platelet-rich plasma (PRP) preparations could exert various therapeutic effects in vitro, the role of leukocytes in PRP has not yet been defined under tendinopathy conditions in vivo. PURPOSE: This study compared the effects of the intratendon delivery of leukocyte-poor PRP (Lp-PRP) versus leukocyte-rich PRP (Lr-PRP) in a rabbit chronic tendinopathy model in vivo...
March 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28286063/motion-corrected-dwi-with-integrated-t2-mapping-for-simultaneous-estimation-of-adc-t2-relaxation-and-perfusion-in-prostate-cancer
#4
M Skorpil, P Brynolfsson, M Engström
OBJECTIVE: Multiparametric magnetic resonance imaging (MRI) and PI-RADS (Prostate Imaging - Reporting and Data System) has become the standard to determine a probability score for a lesion being a clinically significant prostate cancer. T2-weighted and diffusion-weighted imaging (DWI) are essential in PI-RADS, depending partly on visual assessment of signal intensity, while dynamic-contrast enhanced imaging is less important. To decrease inter-rater variability and further standardize image evaluation, complementary objective measures are in need...
March 9, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28263448/bicomponent-ultrashort-echo-time-t2-analysis-for-assessment-of-patients-with-patellar-tendinopathy
#5
Richard Kijowski, John J Wilson, Fang Liu
PURPOSE: To compare bicomponent ultrashort echo time (UTE) T2* parameters of patellar tendon between healthy volunteers and patients with patellar tendinopathy. MATERIALS AND METHODS: This study was performed with Institutional Review Board approval and with all subjects signing informed consent. A UTE- T2* mapping sequence was performed at 3.0T on the knees of 10 healthy volunteers and in 11 patients with patellar tendinopathy. The UTE- T2* relaxation times of the fast relaxing macromolecular bound water component ( T2*F) and the slow relaxing bulk water component ( T2*S) and the fraction of the fast relaxing macromolecular bound water component (FF ) of patellar tendon were measured in all subjects...
March 6, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28258330/good-clinical-and-mri-outcome-after-arthroscopic-autologous-chondrocyte-implantation-for-cartilage-repair-in-the-knee
#6
Rainer Siebold, Ferzan Suezer, Benjamin Schmitt, Siegfried Trattnig, Marco Essig
PURPOSE: To analyze the clinical outcome and cartilage regeneration after all-arthroscopic Autologous Chondrocyte Implantation (ACI) using chondrospheres® (ACT3D) for the treatment of full-size articular cartilage lesions at the knee. METHODS: Thirty consecutive patients treated by all-arthroscopic ACI for full-size articular cartilage lesions in an otherwise healthy knee were enrolled. The defects were located on the femoral condyles (n = 18), in the trochlea (n = 7) and at the patella (n = 5)...
March 3, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28240703/physical-activity-is-related-with-cartilage-quality-in-women-with-knee-osteoarthritis
#7
Matti Munukka, Benjamin Waller, Arja Häkkinen, Miika T Nieminen, Eveliina Lammentausta, Urho M Kujala, Juha Paloneva, Hannu Kautiainen, Ilkka Kiviranta, Ari Heinonen
PURPOSE: To study the relationship between 12-month leisure-time physical activity (LTPA) level and changes in estimated biochemical composition of tibiofemoral cartilage in postmenopausal women with mild knee osteoarthritis (OA). METHODS: Originally 87 volunteer postmenopausal women, aged 60-68 years, with mild knee OA (Kellgren Lawrence I/II and knee pain) participated in a randomised controlled, 4-month aquatic training trial (RCT), after which 76 completed the 12-month post-intervention follow-up period...
February 25, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28239545/new-rapid-accurate-t2-quantification-detects-pathology-in-normal-appearing-brain-regions-of-relapsing-remitting-ms-patients
#8
Timothy M Shepherd, Ivan I Kirov, Erik Charlson, Mary Bruno, James Babb, Daniel K Sodickson, Noam Ben-Eliezer
INTRODUCTION: Quantitative T2 mapping may provide an objective biomarker for occult nervous tissue pathology in relapsing-remitting multiple sclerosis (RRMS). We applied a novel echo modulation curve (EMC) algorithm to identify T2 changes in normal-appearing brain regions of subjects with RRMS (N = 27) compared to age-matched controls (N = 38). METHODS: The EMC algorithm uses Bloch simulations to model T2 decay curves in multi-spin-echo MRI sequences, independent of scanner, and scan-settings...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28213448/detection-and-monitoring-of-acute-myocarditis-applying-quantitative-cardiovascular-magnetic-resonance
#9
Florian von Knobelsdorff-Brenkenhoff, Johannes Schüler, Serkan Dogangüzel, Matthias A Dieringer, Andre Rudolph, Andreas Greiser, Peter Kellman, Jeanette Schulz-Menger
BACKGROUND: Cardiovascular magnetic resonance based on the Lake Louise Criteria is used to make the diagnosis of acute myocarditis. Novel quantitative parametric mapping techniques promise to overcome some of its limitations. We aimed to evaluate quantitative cardiovascular magnetic resonance to detect and monitor acute myocarditis. METHODS AND RESULTS: Eighteen patients with clinical diagnosis of acute myocarditis (25 years [23-38 years]; 78% males) were prospectively enrolled and repeatedly underwent cardiovascular magnetic resonance at 1...
February 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28199043/diagnostic-performance-of-t1-and-t2-mapping-to-detect-intramyocardial-hemorrhage-in-reperfused-st-segment-elevation-myocardial-infarction-stemi-patients
#10
Heerajnarain Bulluck, Stefania Rosmini, Amna Abdel-Gadir, Anish N Bhuva, Thomas A Treibel, Marianna Fontana, Esther Gonzalez-Lopez, Manish Ramlall, Ashraf Hamarneh, Alex Sirker, Anna S Herrey, Charlotte Manisty, Derek M Yellon, James C Moon, Derek J Hausenloy
PURPOSE: To investigate the performance of T1 and T2 mapping to detect intramyocardial hemorrhage (IMH) in ST-segment elevation myocardial infarction (STEMI) patients treated by primary percutaneous coronary intervention (PPCI). MATERIALS AND METHODS: Fifty STEMI patients were prospectively recruited between August 2013 and July 2014 following informed consent. Forty-eight patients completed a 1.5T cardiac magnetic resonance imaging (MRI) with native T1 , T2 , and T2* maps at 4 ± 2 days...
February 15, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28196133/b1-insensitive-t2-mapping-of-healthy-thigh-muscles-using-a-t2-prepared-3d-tse-sequence
#11
Elisabeth Klupp, Dominik Weidlich, Sarah Schlaeger, Thomas Baum, Barbara Cervantes, Marcus Deschauer, Hendrik Kooijman, Ernst J Rummeny, Claus Zimmer, Jan S Kirschke, Dimitrios C Karampinos
PURPOSE: To propose a T2-prepared 3D turbo spin echo (T2prep 3D TSE) sequence for B1-insensitive skeletal muscle T2 mapping and compare its performance with 2D and 3D multi-echo spin echo (MESE) for T2 mapping in thigh muscles of healthy subjects. METHODS: The performance of 2D MESE, 3D MESE and the proposed T2prep 3D TSE in the presence of transmit B1 and B0 inhomogeneities was first simulated. The thigh muscles of ten young and healthy subjects were then scanned on a 3 T system and T2 mapping was performed using the three sequences...
2017: PloS One
https://www.readbyqxmd.com/read/28187264/development-of-a-combined-mr-fingerprinting-and-diffusion-examination-for-prostate-cancer
#12
Alice C Yu, Chaitra Badve, Lee E Ponsky, Shivani Pahwa, Sara Dastmalchian, Matthew Rogers, Yun Jiang, Seunghee Margevicius, Mark Schluchter, William Tabayoyong, Robert Abouassaly, Debra McGivney, Mark A Griswold, Vikas Gulani
Purpose To develop and evaluate an examination consisting of magnetic resonance (MR) fingerprinting-based T1, T2, and standard apparent diffusion coefficient (ADC) mapping for multiparametric characterization of prostate disease. Materials and Methods This institutional review board-approved, HIPAA-compliant retrospective study of prospectively collected data included 140 patients suspected of having prostate cancer. T1 and T2 mapping was performed with fast imaging with steady-state precession-based MR fingerprinting with ADC mapping...
February 10, 2017: Radiology
https://www.readbyqxmd.com/read/28182304/benign-prostatic-hyperplasia-after-prostatic-arterial-embolization-in-a-canine-model-a-3t-multiparametric-mri-and-whole-mount-step-section-pathology-correlated-longitudinal-study
#13
Basen Li, Anhui Xu, Nan Wang, Xiangde Min, Zhaoyan Feng, Ming Deng, Liang Li, Jie Cai, Zhen Kang, Kehua Jiang, Dong Kuang, Liang Wang
PURPOSE: To explore the morphological and functional characteristics of prostatic arterial embolization (PAE) in a canine model of benign prostatic hyperplasia (BPH) with 3T multiparametric magnetic resonance imaging (mp-MRI) and whole-mount step-section pathology correlation. MATERIALS AND METHODS: Eight adult male beagle dogs with hormone-induced BPH underwent 3T mp-MRI before and 1, 3, and 6 months after PAE, with subsequent whole-mount step-section pathologic assessment...
February 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28181027/track-weighted-imaging-methods-extracting-information-from-a-streamlines-tractogram
#14
REVIEW
Fernando Calamante
A whole-brain streamlines data-set (so-called tractogram) generated from diffusion MRI provides a wealth of information regarding structural connectivity in the brain. Besides visualisation strategies, a number of post-processing approaches have been proposed to extract more detailed information from the tractogram. One such approach is based on exploiting the information contained in the tractogram to generate track-weighted (TW) images. In the track-weighted imaging (TWI) approach, a very large number of streamlines are often generated throughout the brain, and an image is then computed based on properties of the streamlines themselves (e...
February 8, 2017: Magma
https://www.readbyqxmd.com/read/28166488/single-shot-t2-mapping-through-overlapping-echo-detachment-oled-planar-imaging
#15
Congbo Cai, Yiqing Zeng, Yuchuan Zhuang, Shuhui Cai, Lin Chen, Xinghao Ding, Lijun Bao, Jianhui Zhong, Zhong Chen
OBJECTIVE: Develop a reliable single-shot T2 mapping method with extra robustness to motion and the potential for realtime dynamic and quantitative MR imaging. METHODS: A singleshot T2 mapping sequence was proposed based on spin-echo planar imaging (SE-EPI) acquisition scheme. Two overlapped echo signals with different T2 weighting were obtained simultaneously by using two small flip-angle excitation pulses and corresponding echo-shifting gradients. Detachment algorithm based on structure similarity constraint was proposed to separate the two echo signals...
January 31, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28164391/multiparametric-cmr-imaging-of-infarct-remodeling-in-a-percutaneous-reperfused-yucatan-mini-pig-model
#16
David Lopez, Jonathan A Pan, Peter M Pollak, Samantha Clarke, Christopher M Kramer, Mark Yeager, Michael Salerno
To further understanding of the temporal evolution and pathophysiology of adverse ventricular remodeling over the first 60 days following a myocardial infarction (MI) in both the infarcted and remote myocardium, we performed multi-parametric cardiac magnetic resonance (CMR) imaging in a closed-chest chronic Yucatan mini-pig model of reperfused MI. Ten animals underwent 90 min left anterior descending artery occlusion and reperfusion. Three animals served as controls. Multiparametric CMR (1.5T) was performed at baseline, Day 2, Day 30 and in four animals on Day 60 after MI...
February 6, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28160369/comparative-t2-and-t1%C3%AF-mapping-of-patellofemoral-cartilage-under-in-situ-mechanical-loading-with-prospective-motion-correction
#17
Thomas Lange, Benjamin R Knowles, Michael Herbst, Kaywan Izadpanah, Maxim Zaitsev
PURPOSE: To demonstrate improved T2 and T1ρ mapping of patellofemoral cartilage with in situ loading by means of prospective motion correction and to assess load-induced changes in healthy subjects. MATERIALS AND METHODS: Established T2 and T1ρ mapping sequences were augmented with prospective motion correction based on optical tracking. Protocols were optimized for robust imaging of the patellofemoral cartilage at a field strength of 3T. Subjects were positioned in the scanner with knee flexion and in situ loading of the patellofemoral joint was performed with a pneumatic loading device...
February 3, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28152249/feasibility-study-for-evaluating-early-lumbar-facet-joint-degeneration-using-axial-t1-%C3%AF-t2-and-t2-mapping-in-cartilage
#18
Jianzhong Hu, Yi Zhang, Chunyue Duan, Xianjing Peng, Ping Hu, Hongbin Lu
PURPOSE: To assess the feasibility of axial T2 , T2*, and T1 ρ mapping of lumbar facet joint (LFJ) cartilage for evaluation of early degeneration. MATERIALS AND METHODS: We examined a total of 176 LFJs from 21 volunteers using axial T2 , T2*, and T1 ρ mapping with a 3.0T magnetic resonance imaging (MRI) scanner. All LFJs were measured and grouped according to the presence of low back pain (LBP), the Weishaupt grading system, and the Pfirrmann grade of the adjacent intervertebral disk (IVD)...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28152242/imaging-of-the-rabbit-supraspinatus-enthesis-at-7-tesla-a-4-week-time-course-after-repair-surgery-and-effect-of-channeling
#19
Guy Trudel, Gerd Melkus, Greg O Cron, Hakim Louati, Adnan Sheikh, Peder E Z Larson, Mark Schweitzer, Peter Lapner, Hans K Uhthoff, Odette Laneuville
PURPOSE: To image the supraspinatus enthesis reformation of rabbit shoulders by magnetic resonance at 7 Tesla (T) using T2 mapping after surgical repair and to assess the effects of channeling aimed at enhancing enthesis reformation. MATERIALS AND METHODS: In 112 rabbits, the distal supraspinatus (SSP) tendon was unilaterally detached and reattached after 1 week. At the first surgery, channeling was performed at the footprint in 64 rabbits. At the second surgery, the SSP tendon of all rabbits was re-attached to the greater tuberosity...
February 2, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28148973/detection-of-changes-in-semi-natural-grasslands-by-cross-correlation-analysis-with-worldview-2-images-and-new-landsat-8-data
#20
Cristina Tarantino, Maria Adamo, Richard Lucas, Palma Blonda
Focusing on a Mediterranean Natura 2000 site in Italy, the effectiveness of the cross correlation analysis (CCA) technique for quantifying change in the area of semi-natural grasslands at different spatial resolutions (grain) was evaluated. In a fine scale analysis (2 m), inputs to the CCA were a) a semi-natural grasslands layer extracted from an existing validated land cover/land use (LC/LU) map (1:5000, time T1) and b) a more recent single date very high resolution (VHR) WorldView-2 image (time T2), with T2 > T1...
March 15, 2016: Remote Sensing of Environment
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