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T2 mapping Imaging

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https://www.readbyqxmd.com/read/29352378/can-histogram-analysis-of-mr-images-predict-aggressiveness-in-pancreatic-neuroendocrine-tumors
#1
Riccardo De Robertis, Bogdan Maris, Nicolò Cardobi, Paolo Tinazzi Martini, Stefano Gobbo, Paola Capelli, Silvia Ortolani, Sara Cingarlini, Salvatore Paiella, Luca Landoni, Giovanni Butturini, Paolo Regi, Aldo Scarpa, Giampaolo Tortora, Mirko D'Onofrio
OBJECTIVES: To evaluate MRI derived whole-tumour histogram analysis parameters in predicting pancreatic neuroendocrine neoplasm (panNEN) grade and aggressiveness. METHODS: Pre-operative MR of 42 consecutive patients with panNEN >1 cm were retrospectively analysed. T1-/T2-weighted images and ADC maps were analysed. Histogram-derived parameters were compared to histopathological features using the Mann-Whitney U test. Diagnostic accuracy was assessed by ROC-AUC analysis; sensitivity and specificity were assessed for each histogram parameter...
January 19, 2018: European Radiology
https://www.readbyqxmd.com/read/29352234/bi-exponential-3d-t1%C3%AF-mapping-of-whole-brain-at-3%C3%A2-t
#2
Rajiv G Menon, Azadeh Sharafi, Johannes Windschuh, Ravinder R Regatte
Detection of multiple relaxation pools using MRI is useful in a number of neuro-pathologies including multiple sclerosis (MS), Alzheimer's, and stroke. In this study we evaluate the feasibility of using T1ρ imaging for the detection of bi-exponential decays in the human brain. A prospective T1ρ imaging study was performed on model relaxation phantoms (eggs) and 7 healthy volunteers. The data was fitted using a single pool and a 2-pool model to estimate mono- and bi-exponential T1ρ maps, respectively. Bi-exponential decays were identified in the gray matter (GM) and white matter (WM) of the brain with 40...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351339/brain-functional-bold-perturbation-modelling-for-forward-fmri-and-inverse-mapping
#3
Zikuan Chen, Jennifer Robinson, Vince Calhoun
PURPOSE: To computationally separate dynamic brain functional BOLD responses from static background in a brain functional activity for forward fMRI signal analysis and inverse mapping. METHODS: A brain functional activity is represented in terms of magnetic source by a perturbation model: χ = χ0 +δχ, with δχ for BOLD magnetic perturbations and χ0 for background. A brain fMRI experiment produces a timeseries of complex-valued images (T2* images), whereby we extract the BOLD phase signals (denoted by δP) by a complex division...
2018: PloS One
https://www.readbyqxmd.com/read/29343659/cardiac-mr-imaging-of-hypertrophic-cardiomyopathy-techniques-findings-and-clinical-relevance
#4
Yasuo Amano, Mitsunobu Kitamura, Hitoshi Takano, Fumi Yanagisawa, Masaki Tachi, Yasuyuki Suzuki, Shinichiro Kumita, Morimasa Takayama
Hypertrophic cardiomyopathy (HCM) is a relatively common myocardial genetic disease having a wide variety of symptoms and prognoses. The most serious complications of HCM are sudden cardiac death induced by ventricular arrhythmia or inappropriate changes in blood pressure, and heart failure. Cardiac MR imaging is a valuable imaging method for detecting HCM because of its accurate measurement of wall thickness and myocardial mass without limited view and the unique ability of late gadolinium enhancement (LGE) to identify myocardial fibrosis related to the prognosis of HCM...
January 18, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29342064/minimally-manipulated-bone-marrow-concentrate-compared-with-microfracture-treatment-of-full-thickness-chondral-defects-a-one-year-study-in-an-equine-model
#5
Constance R Chu, Lisa A Fortier, Ashley Williams, Karin A Payne, Taralyn M McCarrel, Megan E Bowers, Diego Jaramillo
BACKGROUND: Microfracture is commonly performed for cartilage repair but usually results in fibrocartilage. Microfracture augmented by autologous bone marrow concentrate (BMC) was previously shown to yield structurally superior cartilage repairs in an equine model compared with microfracture alone. The current study was performed to test the hypothesis that autologous BMC without concomitant microfracture improves cartilage repair compared with microfracture alone. METHODS: Autologous sternal bone marrow aspirate (BMA) was concentrated using a commercial system...
January 17, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29341356/all-over-the-map-an-interobserver-agreement-study-of-tumor-location-based-on-the-pi-radsv2-sector-map
#6
Matthew D Greer, Joanna H Shih, Tristan Barrett, Sandra Bednarova, Ismail Kabakus, Yan Mee Law, Haytham Shebel, Maria J Merino, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
BACKGROUND: Prostate imaging reporting and data system version 2 (PI-RADSv2) recommends a sector map for reporting findings of prostate cancer mulitparametric MRI (mpMRI). Anecdotally, radiologists may demonstrate inconsistent reproducibility with this map. PURPOSE: To evaluate interobserver agreement in defining prostate tumor location on mpMRI using the PI-RADSv2 sector map. STUDY TYPE: Retrospective. POPULATION: Thirty consecutive patients who underwent mpMRI between October, 2013 and March, 2015 and who subsequently underwent prostatectomy with whole-mount processing...
January 17, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29325780/longitudinal-atlas-for-normative-human-brain-development-and-aging-over-the-lifespan-using-quantitative-susceptibility-mapping
#7
Yuyao Zhang, Hongjiang Wei, Matthew J Cronin, Naying He, Fuhua Yan, Chunlei Liu
Longitudinal brain atlases play an important role in the study of human brain development and cognition. Existing atlases are mainly based on anatomical features derived from T1-and T2-weighted MRI. A 4D developmental quantitative susceptibility mapping (QSM) atlas may facilitate the estimation of age-related iron changes in deep gray matter nuclei and myelin changes in white matter. To this end, group-wise co-registered QSM templates were generated over various age intervals from age 1-83 years old. Registration was achieved by combining both T1-weighted and QSM images...
January 8, 2018: NeuroImage
https://www.readbyqxmd.com/read/29323549/predicting-parametrial-invasion-in-cervical-carcinoma-stages-ib1-ib2-and-iia-diagnostic-accuracy-of-t2-weighted-imaging-combined-with-dwi-at-3-t
#8
Jin-Rong Qu, Lei Qin, Xiang Li, Jun-Peng Luo, Jing Li, Hong-Kai Zhang, Li Wang, Nan-Nan Shao, Shou-Ning Zhang, Yan-Le Li, Cui-Cui Liu, Hai-Liang Li
OBJECTIVE: The objective of our study was to retrospectively evaluate the efficacy of combined analysis of T2-weighted imaging and DWI in the diagnosis of parametrial invasion (PMI) in cervical carcinoma. MATERIALS AND METHODS: The clinical records of 192 patients with cervical carcinoma who met the study requirements were reviewed for this retrospective study. The signal intensities of suspicious PMI tissue were assessed on T2-weighted images, DW images, and apparent diffusion coefficient maps independently by two experienced radiologists...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29319208/image-registration-to-compensate-for-epi-distortion-in-patients-with-brain-tumors-an-evaluation-of-tract-specific-effects
#9
Angela Albi, Antonio Meola, Fan Zhang, Pegah Kahali, Laura Rigolo, Chantal M W Tax, Pelin Aksit Ciris, Walid I Essayed, Prashin Unadkat, Isaiah Norton, Yogesh Rathi, Olutayo Olubiyi, Alexandra J Golby, Lauren J O'Donnell
BACKGROUND AND PURPOSE: Diffusion magnetic resonance imaging (dMRI) provides preoperative maps of neurosurgical patients' white matter tracts, but these maps suffer from echo-planar imaging (EPI) distortions caused by magnetic field inhomogeneities. In clinical neurosurgical planning, these distortions are generally not corrected and thus contribute to the uncertainty of fiber tracking. Multiple image processing pipelines have been proposed for image-registration-based EPI distortion correction in healthy subjects...
January 10, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29315817/dynamic-measurement-of-oxygen-extraction-fraction-using-a-multiecho-asymmetric-spin-echo-mase-pulse-sequence
#10
Yayan Yin, Yaoyu Zhang, Jia-Hong Gao
PURPOSE: The oxygen extraction fraction (OEF), an important parameter for assessing brain oxygen metabolism, is a key marker of brain health. Dynamic measurement of the OEF is currently limited by the long acquisition time. In this study, a noninvasive method for rapidly and effectively assessing dynamic changes in the OEF during brain stimulation is proposed. METHODS: A novel pulse sequence using the multi-echo asymmetric spin echo with an echo-planar imaging acquisition scheme was developed to improve the temporal resolution of functional OEF measurements...
January 8, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29315714/brain-abnormalities-in-cognition-anxiety-and-depression-regulatory-regions-in-adolescents-with-single-ventricle-heart-disease
#11
Nancy A Pike, Bhaswati Roy, Ritika Gupta, Sadhana Singh, Mary A Woo, Nancy J Halnon, Alan B Lewis, Rajesh Kumar
BACKGROUND: Single ventricle heart disease (SVHD) adolescents show cognitive impairments and anxiety and depressive symptoms, indicating the possibility of brain injury in regions that control these functions. However, brain tissue integrity in cognition, anxiety, and depression regulatory sites in SVHD remains unclear. We examined brain tissue changes in SVHD compared to controls using T2-relaxometry procedures, which measure free water content and show tissue injury. METHODS: Proton-density and T2-weighted images, using a 3...
January 6, 2018: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/29314235/accurate-t1-mapping-of-short-t2-tissues-using-a-three-dimensional-ultrashort-echo-time-cones-actual-flip-angle-imaging-variable-repetition-time-3d-ute-cones-afi-vtr-method
#12
Ya-Jun Ma, Xing Lu, Michael Carl, Yanchun Zhu, Nikolaus M Szeverenyi, Graeme M Bydder, Eric Y Chang, Jiang Du
PURPOSE: To develop an accurate T1 measurement method for short T2 tissues using a combination of a 3-dimensional ultrashort echo time cones actual flip angle imaging technique and a variable repetition time technique (3D UTE-Cones AFI-VTR) on a clinical 3T scanner. METHODS: First, the longitudinal magnetization mapping function of the excitation pulse was obtained with the 3D UTE-Cones AFI method, which provided information about excitation efficiency and B1 inhomogeneity...
January 3, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29301780/multiparametric-analysis-of-permeability-and-adc-histogram-metrics-for-classification-of-pediatric-brain-tumors-by-tumor-grade
#13
S Vajapeyam, D Brown, P R Johnston, K I Ricci, M W Kieran, H G W Lidov, T Y Poussaint
BACKGROUND AND PURPOSE: Accurate tumor grading is essential for treatment planning of pediatric brain tumors. We hypothesized that multiparametric analyses of a combination of permeability metrics and ADC histogram metrics would differentiate high- and low-grade tumors with high accuracy. MATERIALS AND METHODS: DTI and dynamic contrast-enhanced MR imaging using T1-mapping with flip angles of 2°, 5°, 10°, and 15°, followed by a 0.1-mmol/kg body weight gadolinium-based bolus was performed on all patients in addition to standard MR imaging...
January 4, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29298564/diffusion-tensor-imaging-of-scarring-necrosis-and-cavitation-based-on-histopathological-findings-in-dogs-with-chronic-spinal-cord-injury-evaluation-of-multiple-diffusion-parameters-and-their-correlations-with-histopathological-findings
#14
Hakyoung Yoon, Won-Jin Moon, Sang-Soep Nahm, Jaehwan Kim, Kidong Eom
The use of diffusion tensor imaging (DTI) for the characterization of various lesion types in dogs with spinal cord injury (SCI) has not been investigated. The purpose of this study was to characterize scarring [loose immature scarring (LIMS), intermediate mature scarring (IMS), and dense mature scarring (DMS)], necrosis, cavitation, and acute hemorrhage using multiple DTI parameters and determine the correlations between the DTI parameters and histopathological finding in dogs with controlled SCI. All imaging data were obtained from the lumbar spinal cord (from L1 to L3) of normal and SCI dogs using a 3-Tesla magnetic resonance imaging scanner...
January 3, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29290809/near-infrared-intraoperative-imaging-of-thoracic-sympathetic-nerves-from-preclinical-study-to-clinical-trial
#15
Kunshan He, Jian Zhou, Fan Yang, Chongwei Chi, Hao Li, Yamin Mao, Bengang Hui, Kun Wang, Jie Tian, Jun Wang
The sympathetic nervous system controls and regulates the activities of the heart and other organs. Sympathetic nervous system dysfunction leads to disease. Therefore, intraoperative real-time imaging of thoracic sympathetic nerves (ITSN) would be of great clinical significance for diagnosis and therapy. The aim of this experimental study was to evaluate the feasibility and validity of intraoperative ITSN using indocyanine green (ICG). METHODS: ITSN using ICG was performed on 10 rabbits to determine its feasibility...
2018: Theranostics
https://www.readbyqxmd.com/read/29289705/molecular-imaging-of-tumor-photoimmunotherapy-evidence-of-photosensitized-tumor-necrosis-and-hemodynamic-changes
#16
Shun Kishimoto, Nobu Oshima, Kazutoshi Yamamoto, Jeeva Munasinghe, Jan Henrik Ardenkjaer-Larsen, James B Mitchell, Peter L Choyke, Murali C Krishna
Near-infrared photoimmunotherapy (NIR PIT) employs the photoabsorbing dye IR700 conjugated to antibodies specific for cell surface epidermal growth factor receptor (EGFR). NIR PIT has shown highly selective cytotoxicity in vitro and in vivo. Cell necrosis is thought to be the main mode of cytotoxicity based mainly on in vitro studies. To better understand the acute effects of NIR PIT, molecular imaging studies were performed to assess its cellular and vascular effects. In addition to in vitro studies for cytotoxicity of NIR PIT, the in vivo tumoricidal effects and hemodynamic changes induced by NIR PIT were evaluated by 13C MRI using hyperpolarized [1,4-13C2] fumarate, R2* mapping from T2*-weighted MRI, and photoacoustic imaging...
December 29, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29288983/automatic-spinal-cord-localization-robust-to-mri-contrasts-using-global-curve-optimization
#17
Charley Gros, Benjamin De Leener, Sara M Dupont, Allan R Martin, Michael G Fehlings, Rohit Bakshi, Subhash Tummala, Vincent Auclair, Donald G McLaren, Virginie Callot, Julien Cohen-Adad, Michaël Sdika
During the last two decades, MRI has been increasingly used for providing valuable quantitative information about spinal cord morphometry, such as quantification of the spinal cord atrophy in various diseases. However, despite the significant improvement of MR sequences adapted to the spinal cord, automatic image processing tools for spinal cord MRI data are not yet as developed as for the brain. There is nonetheless great interest in fully automatic and fast processing methods to be able to propose quantitative analysis pipelines on large datasets without user bias...
December 6, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29288037/simulation-based-quantification-of-native-t1-and-t2-of-the-myocardium-using-a-modified-molli-scheme-and-the-importance-of-magnetization-transfer
#18
Christos G Xanthis, Sebastian Bidhult, Andreas Greiser, Kelvin Chow, Richard B Thompson, Håkan Arheden, Anthony H Aletras
Quantitative cardiovascular Magnetic Resonance Imaging techniques are gaining wide acceptance within the MR community due to their potential to diagnose non-localized disease, guide therapy and improve patient outcome. During the last decade, there has been an increasing interest for developing new techniques that allow for simultaneous quantification of both T1 and T2 maps of myocardium. Newer studies demonstrated that the incorporation of MRI simulations could yield similar results to conventional mapping techniques in the myocardium...
December 26, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29275598/-feasibility-of-susceptibility-weighted-imaging-in-the-evaluation-of-renal-fibrosis-induced-by-unilateral-ureteral-obstruction-in-white-rabbits
#19
J G Zhang, Z Y Xing, T T Zha, X J Tian, S J Xing, X Pan, L Xu, L Pan, W Xing, J Chen
Objective: To evaluate the feasibility of susceptibility weighted imaging (SWI) to reflect the progression of renal fibrosis (RF) induced by unilateral ureteral obstruction (UUO) in rabbits. Methods: Total of 32 New Zealand white rabbits (aged 4-5 months) were used to establish the UUO model (RF group) and were divided into 4 subgroups (including RF-2W group, RF-4W group , RF-6W group and RF-8W group) according to the duration of obstruction(2, 4, 6 and 8 weeks). Another 8 rabbits, underwent sham operation, were used as the control group (Sham group)...
December 5, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29261532/t2-mapping-for-noninvasive-assessment-of-interstitial-edema-in-acute-cardiac-allograft-rejection-in-a-mouse-model-of-heterotopic-heart-transplantation
#20
Dagmar Hartung, Katja Hueper, Rongjun Chen, Marcel Gutberlet, Frank Wacker, Martin Meier, Song Rong, Mi-Sun Jang, Jan H Bräsen, Faikah Gueler
OBJECTIVES: Heart transplantation (HTX) in mice is used to characterize gene-deficient mice and to test new treatment strategies. The purpose was to establish noninvasive magnetic resonance imaging techniques in mice to monitor pathophysiological changes of the allograft during rejection. MATERIALS AND METHODS: Magnetic resonance imaging was performed at baseline and days 1 and 6 after isogenic (n = 10, C57BL/6) and allogenic (n = 12, C57BL/6 to BALB/c) heterotopic HTX on a 7 T small animal scanner...
December 19, 2017: Investigative Radiology
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