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Fusobacterium nucleatum

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https://www.readbyqxmd.com/read/27909688/the-danger-signal-extracellular-atp-is-an-inducer-of-fusobacterium-nucleatum-biofilm-dispersal
#1
Qinfeng Ding, Kai Soo Tan
Plaque biofilm is the primary etiological agent of periodontal disease. Biofilm formation progresses through multiple developmental stages beginning with bacterial attachment to a surface, followed by development of microcolonies and finally detachment and dispersal from a mature biofilm as free planktonic bacteria. Tissue damage arising from inflammatory response to biofilm is one of the hallmark features of periodontal disease. A consequence of tissue damage is the release of ATP from within the cell into the extracellular space...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27899684/high-risk-periodontal-pathogens-contribute-to-the-pathogenesis-of-atherosclerosis
#2
REVIEW
Bradley Field Bale, Amy Lynn Doneen, David John Vigerust
Periodontal disease (PD) is generated by microorganisms. These microbes can enter the general circulation causing a bacteraemia. The result can be adverse systemic effects, which could promote conditions such as cardiovascular disease. Level A evidence supports that PD is independently associated with arterial disease. PD is a common chronic condition affecting the majority of Americans 30 years of age and older. Atherosclerosis remains the largest cause of death and disability. Studies indicate that the adverse cardiovascular effects from PD are due to a few putative or high-risk bacteria: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola or Fusobacterium nucleatum There are three accepted essential elements in the pathogenesis of atherosclerosis: lipoprotein serum concentration, endothelial permeability and binding of lipoproteins in the arterial intima...
November 29, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27898560/fusobacterium-nucleatum-an-unusual-cause-of-subdural-empyema
#3
Denise Yocum
This article describes an uncommon presentation of a subdural empyema in a young man. Because the patient's initial presentation consisted of nonspecific abdominal complaints, subdural empyema was not initially considered. However, a thorough medical history, including recent travel history, and appropriate multidisciplinary consultation, were key to reaching the correct diagnosis.
December 2016: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/27894820/quantitative-detection-of-periodontopathic-bacteria-in-lower-respiratory-tract-specimens-by-real-time-pcr
#4
Kentaro Nagaoka, Katsunori Yanagihara, Yosuke Harada, Koichi Yamada, Yohei Migiyama, Yoshitomo Morinaga, Koichi Izumikawa, Shigeru Kohno
The presence of common periodontopathic bacteria, the Fusobacterium nucleatum-periodonticum-simiae group, Prevotella intermedia, and Porphyromonas gingivalis was determined from respiratory tract specimens of bacterial pneumonia by real-time PCR using universal and species-specific TaqMan probe/primer sets. 42 patients with infectious pneumonia and 45 patients without infectious pneumonia were retrospectively enrolled in clinical studies. Periodontopathic bacterial DNA was found in 57.1% cases of infectious pneumonia and 31...
November 26, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27885964/porphyromonas-gingivalis-capsule-mediated-coaggregation-as-a-virulence-factor-in-mixed-infection-with-fusobacterium-nucleatum
#5
David Polak, Oren Ferdman, Yael Houri-Haddad
BACKGROUND: Porphyromonas gingivalis capsule enables evasion from phagocytosis, invasion of keratinocytes and bacterial survival. In mixed infection, the capsule also participates in coaggregation, which may lead to characteristic virulence not present in the mono-infection. The aim of the study was to evaluate the role of P.gingivalis capsule as a virulence factor in co-aggregated mixed infection with Fusobacterium nucleatum. METHODS: Mixed infections containing F...
November 25, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27876571/fusobacterium-nucleatum-increases-proliferation-of-colorectal-cancer-cells-and-tumor-development-in-mice-by-activating-tlr4-signaling-to-nf%C3%AE%C2%BAb-upregulating-expression-of-microrna-21
#6
Yongzhi Yang, Wenhao Weng, Junjie Peng, Leiming Hong, Lei Yang, Yuji Toiyama, Renyuan Gao, Minfeng Liu, Mingming Yin, Cheng Pan, Hao Li, Bomin Guo, Qingchao Zhu, Qing Wei, Mary-Pat Moyer, Ping Wang, Sanjun Cai, Ajay Goel, Huanlong Qin, Yanlei Ma
BACKGROUND & AIMS: Nearly 20% of the global cancer burden can be linked to infectious agents. Fusobacterium nucleatum promotes tumor formation by epithelial cells via unclear mechanisms. We aimed to identify microRNAs (miRNAs) induced by F nucleatum and evaluate their ability to promote colorectal carcinogenesis in mice. METHODS: Colorectal cancer (CRC) cell lines were incubated with F nucleatum or control reagents and analyzed in proliferation and would healing assays...
November 19, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27859260/inducible-expression-of-a-disintegrin-and-metalloproteinase-8-in-chronic-periodontitis-and-gingival-epithelial-cells
#7
W P P Aung, P Chotjumlong, S Pata, P Montreekachon, C Supanchart, S Khongkhunthian, T Sastraruji, S Krisanaprakornkit
BACKGROUND AND OBJECTIVES: The expression of A Disintegrin and Metalloproteinase 8 (ADAM8) is associated with several inflammatory diseases. Elevated ADAM8 levels have been shown in gingival crevicular fluid of patients with chronic periodontitis. The objective of this study was to investigate ADAM8 expression in chronic periodontitis tissues compared with that in normal tissues. ADAM8 expression and its inductive mechanism were examined in human gingival epithelial cells (HGECs) and human gingival fibroblasts...
November 17, 2016: Journal of Periodontal Research
https://www.readbyqxmd.com/read/27828984/fusobacterium-nucleatum-induced-impairment-of-autophagic-flux-enhances-the-expression-of-proinflammatory-cytokines-via-ros-in-caco-2-cells
#8
Bin Tang, Kun Wang, Yin-Ping Jia, Pan Zhu, Yao Fang, Zhu-Jun Zhang, Xu-Hu Mao, Qian Li, Dong-Zhu Zeng
Fusobacterium nucleatum (F. nucleatum) plays a critical role in gastrointestinal inflammation. However, the exact mechanism by which F. nucleatum contributes to inflammation is unclear. In the present study, it was revealed that F. nucleatum could induce the production of proinflammatory cytokines (IL-8, IL-1β and TNF-α) and reactive oxygen species (ROS) in Caco-2 colorectal) adenocarcinoma cells. Furthermore, ROS scavengers (NAC or Tiron) could decrease the production of proinflammatory cytokines during F...
2016: PloS One
https://www.readbyqxmd.com/read/27811909/fusobacterium-nucleatum-in-colorectal-carcinoma-tissue-according-to-tumor-location
#9
Kosuke Mima, Yin Cao, Andrew T Chan, Zhi Rong Qian, Jonathan A Nowak, Yohei Masugi, Yan Shi, Mingyang Song, Annacarolina da Silva, Mancang Gu, Wanwan Li, Tsuyoshi Hamada, Keisuke Kosumi, Akiko Hanyuda, Li Liu, Aleksandar D Kostic, Marios Giannakis, Susan Bullman, Caitlin A Brennan, Danny A Milner, Hideo Baba, Levi A Garraway, Jeffrey A Meyerhardt, Wendy S Garrett, Curtis Huttenhower, Matthew Meyerson, Edward L Giovannucci, Charles S Fuchs, Reiko Nishihara, Shuji Ogino
OBJECTIVES: Evidence suggests a possible role of Fusobacterium nucleatum in colorectal carcinogenesis, especially in right-sided proximal colorectum. Considering a change in bowel contents and microbiome from proximal to distal colorectal segments, we hypothesized that the proportion of colorectal carcinoma enriched with F. nucleatum might gradually increase along the bowel subsites from rectum to cecum. METHODS: A retrospective, cross-sectional analysis was conducted on 1,102 colon and rectal carcinomas in molecular pathological epidemiology databases of the Nurses' Health Study and the Health Professionals Follow-up Study...
November 3, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27809921/effects-by-periodontitis-on-pristane-induced-arthritis-in-rats
#10
Kaja Eriksson, Erik Lönnblom, Gregory Tour, Anna Kats, Piotr Mydel, Pierre Georgsson, Catharina Hultgren, Nastya Kharlamova, Ulrika Norin, Jörgen Jönsson, Anna Lundmark, Annelie Hellvard, Karin Lundberg, Leif Jansson, Rikard Holmdahl, Tülay Yucel-Lindberg
BACKGROUND: An infection-immune association of periodontal disease with rheumatoid arthritis has been suggested. This study aimed to investigate the effect of pre-existing periodontitis on the development and the immune/inflammatory response of pristane-induced arthritis. METHODS: We investigated the effect of periodontitis induced by ligature placement and Porphyromonas gingivalis (P. gingivalis) infection, in combination with Fusobacterium nucleatum to promote its colonization, on the development of pristane-induced arthritis (PIA) in rats (Dark Agouti)...
November 3, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27808349/gehirnabszess-nach-parodontaler-therapie-ein-fallbericht-%C3%A3-ber-einen-gehirnabszess-assoziiert-mit-fusobacterium-nucleatum-nach-parodontaler-therapie
#11
Johan Peter Woelber, Anne Kruse, Gilgamesh Hanna, Michael Ermer, Andreas Beringer, Petra Ratka-Kruege
Background Nonsurgical periodontal treatment implicates bacteraemia. In rare cases oral pathogens can be found associated with abscesses of brain or liver Case Description A brain abscess was found in a patient after several periodontal treatments causing neurological seizures. In the drain masses of Fusobacterium nucleatum were found. An oral examination revealed a severe periodontally damaged dentition. The woman had been in a generally healthy condition before the event. After neurosurgical treatment and intravenous antibiotic therapy the patient fully recovered...
2016: Swiss Dental Journal
https://www.readbyqxmd.com/read/27797940/quantitation-of-faecal-fusobacterium-improves-faecal-immunochemical-test-in-detecting-advanced-colorectal-neoplasia
#12
Sunny H Wong, Thomas N Y Kwong, Tai-Cheong Chow, Arthur K C Luk, Rudin Z W Dai, Geicho Nakatsu, Thomas Y T Lam, Lin Zhang, Justin C Y Wu, Francis K L Chan, Simon S M Ng, Martin C S Wong, Siew C Ng, William K K Wu, Jun Yu, Joseph J Y Sung
OBJECTIVE: There is a need for an improved biomarker for colorectal cancer (CRC) and advanced adenoma. We evaluated faecal microbial markers for clinical use in detecting CRC and advanced adenoma. DESIGN: We measured relative abundance of Fusobacterium nucleatum (Fn), Peptostreptococcus anaerobius (Pa) and Parvimonas micra (Pm) by quantitative PCR in 309 subjects, including 104 patients with CRC, 103 patients with advanced adenoma and 102 controls. We evaluated the diagnostic performance of these biomarkers with respect to faecal immunochemical test (FIT), and validated the results in an independent cohort of 181 subjects...
October 24, 2016: Gut
https://www.readbyqxmd.com/read/27793138/consequences-of-orthodontic-treatment-in-malocclusion-patients-clinical-and-microbial-effects-in-adults-and-children
#13
Li Guo, Ying Feng, Hong-Gang Guo, Bo-Wen Liu, Yang Zhang
BACKGROUND: Malocclusion is a common disease of oral and maxillofacial region. The study was aimed to investigate levels changes of periodontal pathogens in malocclusion patients before, during and after orthodontic treatments, and to confirm the difference between adults and children. METHOD: One hundred and eight malocclusion patients (46 adults and 62 children at the school-age) were randomly selected and received orthodontic treatment with fixed orthodontic appliances...
October 28, 2016: BMC Oral Health
https://www.readbyqxmd.com/read/27792427/changes-in-salivary-periodontal-pathogens-after-orthodontic-treatment-an-in-vivo-prospective-study
#14
Kyungsun Kim, Woo-Sun Jung, Soha Cho, Sug-Joon Ahn
OBJECTIVE:   To analyze the initial changes in salivary levels of periodontal pathogens after orthodontic treatment with fixed appliances. MATERIALS AND METHODS:   The subjects consisted of 54 adult patients. The Simplified Oral Hygiene Index, Plaque Index, and Gingival Index were measured as periodontal parameters. Both the plaque and gingival indexes were obtained from the central and lateral incisors and first molars of both arches. Whole saliva and periodontal parameters were obtained at the following four time points: immediately before debonding (T1), 1 week after debonding (T2), 5 weeks after debonding (T3), and 13 weeks after debonding (T4)...
November 2016: Angle Orthodontist
https://www.readbyqxmd.com/read/27786617/comparison-of-two-different-sampling-methods-for-subgingival-plaque-subgingival-paper-points-or-mouthrinse-sample
#15
Katrin Nickles, Susanne Scharf, Lasse Röllke, Bettina Dannewitz, Peter Eickholz
OBJECTIVE: The collection of subgingival plaque samples with paper points is time-consuming and accident-sensitive. The collection of saliva, however, is simple and contains pathogens of all intraoral surfaces. The aim of this study is to investigate whether sampling with a mouthrinse (mouthrinse sample/MSP; test) leads to comparable results as the standard sampling method (multiple site test from the deepest pocket of each quadrant/MT4; control). METHODS: In 50 patients with periodontitis, subgingival plaque was sampled from the deepest pocket of each quadrant by using paper points and by gaining saliva with a saline mouthrinse...
October 27, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27777193/-analysis-of-causes-and-whole-microbial-structure-in-a-case-of-rampant-caries
#16
Xiao-Yu Hu, Yu-Fei Yao, Bo-Miao Cui, Jun Lv, Xin Shen, Biao Ren, Ming-Yun Li, Qiang Guo, Rui-Jie Huang, Yan Li
OBJECTIVE: To analyze the whole microbial structure in a case of rampant caries to provide evidence for its prevention and treatment. METHODS: Clinical samples including blood, supragingival plaque, plaque in the caries cavity, saliva, and mucosal swabs were collected with the patient's consent. The blood sample was sent for routine immune test, and the others samples were stained using Gram method and cultured for identifying colonies and 16S rRNA sequencing. DNA was extracted from the samples and tested for the main cariogenic bacterium (Streptococcus mutans) with qPCR, and the whole microbial structure was analyzed using DGGE...
October 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27769987/human-microbiome-fusobacterium-nucleatum-in-esophageal-cancer-tissue-is-associated-with-prognosis
#17
Kensuke Yamamura, Yoshifumi Baba, Shigeki Nakagawa, Kosuke Mima, Keisuke Miyake, Kenichi Nakamura, Hiroshi Sawayama, Koichi Kinoshita, Takatsugu Ishimoto, Masaaki Iwatsuki, Yasuo Sakamoto, Yoichi Yamashita, Naoya Yoshida, Masayuki Watanabe, Hideo Baba
PURPOSE: Fusobacterium nucleatum (F. nucleatum) is a component of the human microbiome that primarily inhabits the oral cavity. It causes periodontal disease and has also been implicated in the development of human cancers. Although there are several reports of the relationship between F. nucleatum and the clinical outcome in human cancers, its prognostic significance in esophageal cancer remains unclear. EXPERIMENTAL DESIGN: We quantified F. nucleatum DNA in 325 resected esophageal cancer specimens by qPCR...
October 21, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27762731/strain-specific-impact-of-fusobacterium-nucleatum-on-neutrophil-function
#18
Şivge Kurgan, Shevali Kansal, Daniel Nguyen, Danielle Stephens, Yannis Koroneos, Hatice Hasturk, Thomas E Van Dyke, Alpdogan Kantarci
BACKGROUND: Neutrophil function is critical for the initiation and progression of infecto-inflammatory diseases. Key quorum-sensing plaque bacteria such as Fusobacterium nucleatum act as bridging species between early and late colonizer pathogens such as Porphyromonas gingivalis as the biofilm ages and periodontal inflammation increases. This study was designed to determine the impact of different F. nucleatum strains on neutrophil function. MATERIALS AND METHODS: HL-60 cells were differentiated into neutrophil-like cells and cultured with F...
October 20, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27757550/efficacy-of-various-side-to-side-toothbrushes-and-impact-of-brushing-parameters-on-noncontact-biofilm-removal-in-an-interdental-space-model
#19
Julia C Schmidt, Monika Astasov-Frauenhoffer, Tuomas Waltimo, Roland Weiger, Clemens Walter
OBJECTIVES: The objective of this study was to evaluate the efficacy of four different side-to-side toothbrushes and the impact of various brushing parameters on noncontact biofilm removal in an adjustable interdental space model. MATERIALS AND METHODS: A three-species biofilm, consisting of Porphyromonas gingivalis, Fusobacterium nucleatum, and Streptococcus sanguinis, was formed in vitro on protein-coated titanium disks using a flow chamber combined with a static biofilm growth model...
October 19, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27753430/light-activated-antimicrobial-agents-can-inactivate-oral-malodour-causing-bacteria
#20
Marika Rai, David Spratt, Paola R Gomez-Pereira, Jay Patel, Sean P Nair
Oral malodour is a common condition which affects a large proportion of the population, resulting in social, emotional and psychological stress. Certain oral bacteria form a coating called a biofilm on the tongue dorsum and degrade organic compounds releasing volatile sulfur compounds that are malodourous. Current chemical treatments for oral malodour such as mouthwashes containing chlorhexidine or essential oils, are not sufficiently effective at reducing the bacterial load on the tongue. One potential alternative to current chemical treatments for oral malodour is the use of light activated antimicrobial agents (LAAAs), which display no toxicity or antimicrobial activity in the dark, but when exposed to light of a specific wavelength produce reactive oxygen species which induce damage to target cells in a process known as photodynamic inactivation...
October 18, 2016: Journal of Breath Research
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