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Fusobacterium nucleatum

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https://www.readbyqxmd.com/read/28633639/fusobacterial-liver-abscess-a-case-report-and-review-of-the-literature
#1
Dilip Jayasimhan, Linus Wu, Paul Huggan
BACKGROUND: Fusobacteriae are facultative anaerobic gram-negative bacilli which cause a range of invasive infections, amongst which pyogenic liver abscesses are rare. We describe a case of Fusobacterium nucleatum liver abscess and review the relevant literature. CASE PRESENTATION: A 51-year-old lady presented with a 4-day history of abdominal pain, diarrhoea, fever, rigors, and lethargy. Imaging revealed an abscess which was drained. Cultures of the blood and abscess aspirate grew Fusobacterium nucleatum and Prevotella pleuritidis respectively...
June 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28606669/effectiveness-in-the-removal-of-endotoxins-and-microbiological-profile-in-primary-endodontic-infections-using-3-different-instrumentation-systems-a-randomized-clinical-study
#2
Daiana Cavalli, Cássia Cestari Toia, Esteban Isai Flores Orozco, Rayana Duarte Khoury, Flávia Goulart da Rosa Cardoso, Marcelo Corrêa Alves, Cláudio Antônio Talge Carvalho, Marcia Carneiro Valera
INTRODUCTION: This clinical study was conducted to correlate the microbiological profile and levels of endotoxins found in primary endodontic infection with the presence of clinical features and to evaluate the removal of microorganisms and endotoxins using rotary, reciprocating, and hybrid systems for biomechanical preparation. METHODS: Thirty single root canals with primary endodontic infection were evaluated with signs and symptoms and were randomly divided into 3 groups according to the instrumentation system used (n = 10) as follows: rotary Mtwo instruments (VDW, Munich, Germany) with 8 files, the reciprocating Reciproc system (VDW) with a single file, and Genius hybrid instruments with 3 files (1 rotary and 2 reciprocating files) with irrigation using 24 mL 2...
June 9, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28597080/intratumoral-fusobacterium-nucleatum-abundance-correlates-with-macrophage-infiltration-and-cdkn2a-methylation-in-microsatellite-unstable-colorectal-carcinoma
#3
Hye Eun Park, Jung Ho Kim, Nam-Yun Cho, Hye Seung Lee, Gyeong Hoon Kang
Fusobacterium nucleatum (Fn), a specific species of gut microbiota, has been suggested to be enriched in the microsatellite instability-high (MSI-H) molecular subtype of colorectal carcinomas (CRCs). However, the clinicopathologic and molecular factors that interact with Fn in MSI-H CRCs are poorly understood. In this study, 16S ribosomal RNA gene DNA sequence of Fn was quantitatively measured by real-time polymerase chain reaction in tumor DNA samples from a total of 160 surgically resected MSI-H CRC tissues...
June 8, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28587675/bactericidal-effects-of-310%C3%A2-nm-ultraviolet-light-emitting-diode-irradiation-on-oral-bacteria
#4
Ayuko Takada, Kenji Matsushita, Satoru Horioka, Yasushi Furuichi, Yasunori Sumi
BACKGROUND: Ultraviolet (UV) light is used for phototherapy in dermatology, and UVB light (around 310 nm) is effective for treatment of psoriasis and atopic dermatitis. In addition, it is known that UVC light (around 265 nm) has a bactericidal effect, but little is known about the bactericidal effect of UVB light. In this study, we examined the bactericidal effects of UVB-light emitting diode (LED) irradiation on oral bacteria to explore the possibility of using a 310 nm UVB-LED irradiation device for treatment of oral infectious diseases...
June 6, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28582482/fusobacterium-and-colorectal-cancer-causal-factor-or-passenger-results-from-a-large-colorectal-cancer-screening-study
#5
Efrat L Amitay, Simone Werner, Marius Vital, Dietmar H Pieper, Daniela Höfler, Indra-Jasmin Gierse, Julia Butt, Yesilda Balavarca, Katarina Cuk, Hermann Brenner
Colorectal cancer is a leading cause of morbidity and mortality worldwide in both men and women. The gut microbiome is increasingly recognized as having an important role in human health and disease. Fusobacterium has been identified in former studies as a leading gut bacterium associated with colorectal cancer but it is still not clear if it plays an oncogenic role. In the current study, fecal samples were collected prior to bowel preparation from participants of screening colonoscopy in the German BliTz study...
June 5, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28580924/crystal-structure-of-n-acetylmannosamine-kinase-from-fusobacterium-nucleatum
#6
Rhawnie Caing-Carlsson, Parveen Goyal, Amit Sharma, Swagatha Ghosh, Thanuja Gangi Setty, Rachel A North, Rosmarie Friemann, S Ramaswamy
Sialic acids comprise a varied group of nine-carbon amino sugars that are widely distributed among mammals and higher metazoans. Some human commensals and bacterial pathogens can scavenge sialic acids from their environment and degrade them for use as a carbon and nitrogen source. The enzyme N-acetylmannosamine kinase (NanK; EC 2.7.1.60) belongs to the transcriptional repressors, uncharacterized open reading frames and sugar kinases (ROK) superfamily. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate...
June 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28554609/biofilm-induced-changes-to-the-composite-surface
#7
Ivana Nedeljkovic, Jan De Munck, Andreea-Alexandra Ungureanu, Vera Slomka, Carmen Bartic, Anja Vananroye, Christian Clasen, Wim Teughels, Bart Van Meerbeek, Kirsten L Van Landuyt
OBJECTIVES: Composites may undergo biodegradation in the oral cavity. The objective was to investigate the effect of single- and multi-species biofilms on the surface roughness and topography of two composites. METHODS: Disk-shaped specimens of a paste-like, Bis-GMA-free (Gradia Direct Anterior, GC), and a flowable, Bis-GMA-based composite (Tetric EvoFlow, Ivoclar-Vivadent) were prepared. After ethylene-oxide sterilization (38°C), specimens (n=3) were incubated with Streptococcus mutans or mixed bacterial culture (Streptococcus mutans, Streptococcus sanguinis, Actinomyces naeslundii and Fusobacterium nucleatum)...
May 26, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28554093/new-bicyclic-brominated-furanones-as-potent-autoinducer-2-quorum-sensing-inhibitors-against-bacterial-biofilm-formation
#8
Ji Su Park, Eun-Ju Ryu, Linzi Li, Bong-Kyu Choi, B Moon Kim
Bacterial behaviors such as virulence factor secretion and biofilm formation are critical for survival, and are effectively regulated through quorum sensing, a mechanism of intra- and interspecies communication in response to changes in cell density and species complexity. Many bacterial species colonize host tissues and form a defensive structure called a biofilm, which can be the basis of inflammatory diseases. Periodontitis, a chronic inflammatory disease affecting the periodontium, is caused by subgingival biofilms related to periodontopathogens...
May 17, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28516038/detection-of-fusobacterium-nucleatum-in-culture-negative-brain-abscess-by-broad-spectrum-bacterial-16s-rrna-gene-pcr
#9
Catherine Chakvetadze, Anastasia Purcarea, Aurelia Pitsch, Jonathan Chelly, Sylvain Diamantis
BACKGROUND: Fusobacterium nucleatum is a strict anaerobic microorganism commensal to the human oropharynx and gastrointestinal tract, which causes a wide spectrum of human diseases and it is an important pathogen in abscesses. CASE PRESENTATION: We report the case of a previously healthy 64-year-old woman with multiple abscesses due to Fusobacterium nucleatum, involving liver, pleura and brain. Fusobacterium was not recovered from blood cultures nor from culture of hepatic, pleural and brain drain fluid...
2017: IDCases
https://www.readbyqxmd.com/read/28512280/herpes-simplex-1-and-periopathogen-role-in-peri-implantitis
#10
S Parthiban, Nizar Ahmed, T Ramakrishnan, V Balakumar, Manoj Raja, Himanshu Shekhar
INTRODUCTION: The objectives of this study were to compare the qualitative and quantitative profiles of herpes simplex virus type I (HSV-1) in implant surfaces between participants with peri-implantitis (PI) and Healthy peri-implant tissues and to quantitatively assess the relation between HSV-1 and periopathogens inside the microbiological profile associated with PI. MATERIALS AND METHODS: A total of 40 patients with PI and 40 with healthy peri-implant tissues (HI) were recruited...
May 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28500338/inflammatory-bacteriome-featuring-fusobacterium-nucleatum-and-pseudomonas-aeruginosa-identified-in-association-with-oral-squamous-cell-carcinoma
#11
Nezar Noor Al-Hebshi, Akram Thabet Nasher, Mohamed Yousef Maryoud, Husham E Homeida, Tsute Chen, Ali Mohamed Idris, Newell W Johnson
Studies on the possible association between bacteria and oral squamous cell carcinoma (OSCC) remain inconclusive, largely due to methodological variations/limitations. The objective of this study was to characterize the species composition as well as functional potential of the bacteriome associated with OSCC. DNA obtained from 20 fresh OSCC biopsies (cases) and 20 deep-epithelium swabs (matched control subjects) was sequenced for the V1-V3 region using Illumina's 2 × 300 bp chemistry. High quality, non-chimeric merged reads were classified to species level using a prioritized BLASTN-algorithm...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28492362/microbiota-analysis-of-biofilms-on-experimental-abutments-mimicking-dental-implants-an-in-vivo-model
#12
Berta Cortés-Acha, Rui Figueiredo, Ramón Seminago, Francisco J Roig, Carlos Llorens, Eduard Valmaseda-Castellón
BACKGROUND: The microbiota colonizing dental implants has been said to be similar to the microbiome surrounding teeth. In the absence of inflammation, a biofilm with pathological bacteria can cover implant surfaces exposed to the oral cavity, due for example, to a remodeling process. The aim of the present study was to identify the microbiota surrounding exposed dental implants in patients with and without a history of periodontitis through a deep-sequencing approach. METHODS: An experimental abutment with the same surface and structure as a commercially available dental implant was used...
May 11, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28486933/influence-of-chronic-azithromycin-treatment-on-the-composition-of-the-oropharyngeal-microbial-community-in-patients-with-severe-asthma
#13
Guido Lopes Dos Santos Santiago, Guy Brusselle, Kenny Dauwe, Pieter Deschaght, Chris Verhofstede, Dries Vaneechoutte, Ellen Deschepper, Paul Jordens, Guy Joos, Mario Vaneechoutte
BACKGROUND: This study of the oropharyngeal microbiome complements the previously published AZIthromycin in Severe ASThma (AZISAST) clinical trial, where the use of azithromycin was assessed in subjects with exacerbation-prone severe asthma. Here, we determined the composition of the oropharyngeal microbial community by means of deep sequencing of the amplified 16S rRNA gene in oropharyngeal swabs from patients with exacerbation-prone severe asthma, at baseline and during and after 6 months treatment with azithromycin or placebo...
May 10, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28483840/fusobacterium-nucleatum-subspecies-animalis-influences-pro-inflammatory-cytokine-expression-and-monocyte-activation-in-human-colorectal-tumors
#14
Xiangcang Ye, Rui Wang, Rajat Bhattacharya, Delphine Boulbes, Fan Fan, Ling Xia, Harish Adoni, Nadim J Ajami, Matthew C Wong, Daniel P Smith, Joseph F Petrosino, Susan Venable, Wei Qiao, Veerabhadran Baladandayuthapani, Dipen M Maru, Lee M Ellis
Chronic infection and associated inflammation have long been suspected to promote human<br />carcinogenesis. Recently, certain gut bacteria, including some in the Fusobacterium genus, have been implicated in playing a role in human colorectal cancer (CRC) development. However, the Fusobacterium species and subspecies involved and their oncogenic mechanisms remain to be determined. We sought to identify the specific Fusobacterium spp. and ssp. in clinical CRC specimens by targeted sequencing of Fusobacterium 16S ribosomal RNA gene...
May 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28470309/characterization-of-non-dialyzable-constituents-from-cranberry-juice-that-inhibit-adhesion-co-aggregation-and-biofilm-formation-by-oral-bacteria
#15
C C Neto, K A Penndorf, M Feldman, S Meron-Sudai, Z Zakay-Rones, D Steinberg, M Fridman, Y Kashman, I Ginsburg, I Ofek, E I Weiss
An extract prepared from cranberry juice by dialysis known as nondialyzable material (NDM) has been shown previously to possess anti-adhesion activity toward microbial species including oral bacteria, uropathogenic Escherichia coli and Helicobacter pylori. Bioassay-guided fractionation of cranberry NDM was therefore undertaken to identify the anti-adhesive constituents. An aqueous acetone-soluble fraction (NDMac) obtained from Sephadex LH-20 inhibited adhesion-linked activities by oral bacteria, including co-aggregation of oral bacteria Fusobacterium nucleatum with Streptococcus sanguinis or Porphyromonas gingivalis, and biofilm formation by Streptococcus mutans...
May 24, 2017: Food & Function
https://www.readbyqxmd.com/read/28460249/effect-of-preparation-method-and-storage-period-on-the-stability-of-saliva-dna
#16
Maribasappa Karched, Radhika G Bhardwaj, Eunice M Pauline, Swapna George, Sirkka Asikainen
Saliva is an attractive source for oral microbial detection and quantification since sampling is non-invasive and rapid. OBJECTIVES: To determine whether different saliva preparation methods or preservation time periods affect DNA stability. METHODS: Saliva samples from 4 healthy adult volunteers were processed to obtain 3 different preparations: whole saliva, and after centrifugation pellet and supernatant. Purified DNA (MasterPure™) from each sample was divided into 4 aliquots, one for immediate analysis and 3 (stored at -80°C) for later analyses after 1 week and 2 and 6 months...
April 20, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28442908/antibacterial-activity-and-cytocompatibility-of-an-implant-coating-consisting-of-tio2-nanotubes-combined-with-a-gl13k-antimicrobial-peptide
#17
Tao Li, Na Wang, Su Chen, Ran Lu, Hongyi Li, Zhenting Zhang
Prevention of implant-associated infections at an early stage of surgery is highly desirable for the long-term efficacy of implants in dentistry and orthopedics. Infection prophylaxis using conventional antibiotics is becoming less effective due to the development of bacteria resistant to multiple antibiotics. An ideal strategy to conquer bacterial infections is the local delivery of antibacterial agents. Therefore, antimicrobial peptide (AMP) eluting coatings on implant surfaces is a promising alternative...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28423670/invasive-fusobacterium-nucleatum-activates-beta-catenin-signaling-in-colorectal-cancer-via-a-tlr4-p-pak1-cascade
#18
Yongyu Chen, Yan Peng, Jiahui Yu, Ting Chen, Yaxin Wu, Lei Shi, Qing Li, Jiao Wu, Xiangsheng Fu
The underlying mechanism of Fusobacterium nucleatum (Fn) in the carcinogenesis of colorectal cancer (CRC) is poorly understood. Here, we examined Fn abundance in CRC tissues, as well as β-catenin, TLR4 and PAK1 protein abundance in Fn positive and Fn negative CRCs. Furthermore, we isolated a strain of Fn (F01) from a CRC tissue and examined whether Fn (F01) infection of colon cancer cells activated β-catenin signaling via the TLR4/P-PAK1/P-β-catenin S675 cascade. Invasive Fn was abundant in 62.2% of CRC tissues...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28416491/locoregional-effects-of-microbiota-in-a-preclinical-model-of-colon-carcinogenesis
#19
Sarah Tomkovich, Ye Yang, Kathryn Winglee, Josee Gauthier, Marcus Mühlbauer, Xiaolun Sun, Mansour Mohamadzadeh, Xiuli Liu, Patricia Martin, Gary P Wang, Eric Oswald, Anthony A Fodor, Christian Jobin
Inflammation and microbiota are critical components of intestinal tumorigenesis. To dissect how the microbiota contributes to tumor distribution, we generated germ-free (GF) Apc(Min/+) and Apc(Min/+) ;Il10(-/-) mice and exposed them to specific-pathogen-free (SPF) or colorectal cancer-associated bacteria. We found that colon tumorigenesis significantly correlated with inflammation in SPF-housed Apc(Min/+) ;Il10(-/-) , but not in Apc(Min/+) mice. In contrast, small intestinal neoplasia development significantly correlated with age in both Apc(Min/+) ;Il10(-/-) and Apc(Min/+) mice...
May 15, 2017: Cancer Research
https://www.readbyqxmd.com/read/28413322/improved-antimicrobial-effect-of-ginseng-extract-by-heat-transformation
#20
Peng Xue, Yang Yao, Xiu-Shi Yang, Jia Feng, Gui-Xing Ren
BACKGROUND: The incidence of halitosis has a prevalence of 22-50% throughout the world and is generally caused by anaerobic oral microorganisms, such as Fusobacterium nucleatum, Clostridium perfringens, and Porphyromonas gingivalis. Previous investigations on the structure-activity relationships of ginsenosides have led to contrasting results. Particularly, the antibacterial activity of less polar ginsenosides against halitosis-related bacteria has not been reported. METHODS: Crude saponins extracted from the Panax quinquefolius leaf-stem (AGS) were treated at 130°C for 3 h to obtain heat-transformed saponins (HTS)...
April 2017: Journal of Ginseng Research
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