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Fusobacterium nucleatum

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https://www.readbyqxmd.com/read/29125911/5-lipoxygenase-knockout-aggravated-apical-periodontitis-in-a-murine-model
#1
Y Wu, H Sun, B Yang, X Liu, J Wang
5-Lipoxygenase (5-LO) plays a vital role in the host innate immune response, including bacteria-induced inflammation. Apical periodontitis (AP) is due to immune disorders caused by imbalances between bacterial invasion and subsequent host defense response. In this work, we investigated the role of 5-lipoxygenase in AP by using 5- lo knockout mice (5- lo-/- mice). Results showed that 5- lo-/- mice had greater periapical bone loss and more osteoclasts positive for tartrate-resistant acid phosphatase staining than did wild-type mice, as determined by micro-computed tomography and histologic staining...
November 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29121411/probiotic-lactobacillus-rhamnosus-gg-prevents-alveolar-bone-loss-in-a-mouse-model-of-experimental-periodontitis
#2
Simona M Gatej, Victor Marino, Richard Bright, Tracy R Fitzsimmons, Neville Gully, Peter Zilm, Rachel J Gibson, Suzanne Edwards, Peter M Bartold
AIM: This study investigated the role of Lactobacillus rhamnosus GG on bone loss and local and systemic inflammation in an in vivo mouse model of experimental periodontitis. MATERIALS AND METHODS: Experimental periodontitis was induced in mice by oral inoculation with Porphyromonas gingivalis and Fusobacterium nucleatum over a period of 44 days. The probiotic LGG was administered via oral inoculation or oral gavage prior to, and during disease induction. The antimicrobial activity of LGG on the inoculum was also tested...
November 9, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29110296/the-combined-and-individual-impact-of-diabetes-and-smoking-on-key-subgingival-periodontal-pathogens-in-patients-with-chronic-periodontitis
#3
C R Joaquim, T S Miranda, L M Marins, H D P Silva, M Feres, L C Figueiredo, P M Duarte
BACKGROUND AND OBJECTIVE: Comprehension of the similarities and differences in the composition of the subgingival microbiota of patients with diabetes mellitus (DM), smokers or smokers with DM is an important step in developing therapies specific for these groups at risk for periodontitis. Therefore, the aim of this study was to compare the combined and individual effects of DM and smoking on the levels and prevalence of key subgingival periodontal pathogens in patients with chronic periodontitis...
November 6, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29081982/the-making-of-a-miscreant-tobacco-smoke-and-the-creation-of-pathogen-rich-biofilms
#4
Samir A Shah, Sukirth M Ganesan, Saradhadevi Varadharaj, Shareef M Dabdoub, John D Walters, Purnima S Kumar
We have previously reported that oral biofilms in clinically healthy smokers are pathogen-rich, and that this enrichment occurs within 24 h of biofilm formation. The present investigation aimed to identify a mechanism by which smoking creates this altered community structure. By combining in vitro microbial-mucosal interface models of commensal (consisting of Streptococcus oralis, Streptococcus sanguis, Streptococcus mitis, Actinomyces naeslundii, Neisseria mucosa and Veillonella parvula) and pathogen-rich (comprising S...
2017: NPJ Biofilms and Microbiomes
https://www.readbyqxmd.com/read/29081665/clinical-significance-of-fusobacterium-nucleatum-epithelial-mesenchymal-transition-and-cancer-stem-cell-markers-in-stage-iii-iv-colorectal-cancer-patients
#5
Xuebing Yan, Liguo Liu, Hao Li, Huanlong Qin, Zhenliang Sun
Colorectal cancer (CRC) is a common digestive malignancy and emerging studies have closely linked its initiation and development with gut microbiota changes. Fusobacterium nucleatum (Fn) has been recently identified as a pathogenic bacteria for CRC; however, its prognostic significance for patients is poorly investigated and is less for patients within late stage. Therefore, in this study, we made efforts to analyze its level and prognostic significance in a retrospective cohort of 280 stage III/IV CRC patients...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29079615/%C3%AE-glucanase-activity-of-the-oral-bacterium-tannerella-forsythia-contributes-to-the-growth-of-a-partner-species-fusobacterium-nucleatum-in-co-biofilms
#6
Kiyonobu Honma, Angela Ruscitto, Ashu Sharma
Tannerella forsythia and Fusobacterium nucleatum are dental plaque bacteria implicated in the development of periodontitis. These two species have been shown to form synergistic biofilms and found to be closely associated in dental plaque biofilms. A number of genetic loci for TonB-dependent membrane receptors (TDR) for glycan acquisition, with many existing in association with genes coding for enzymes involved in the breakdown of complex glycans, have been identified in T. forsythia In this study, we focused on a locus, BFO_0186 -- BFO_0188, that codes for a predicted TDR-SusD transporter along with a putative β-glucan hydrolyzing enzyme (BFO_0186)...
October 27, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29033369/fecal-clostridium-symbiosum-for-noninvasive-detection-of-early-and-advanced-colorectal-cancer-test-and-validation-studies
#7
Yuan-Hong Xie, Qin-Yan Gao, Guo-Xiang Cai, Xiao-Ming Sun, Tian-Hui Zou, Hui-Min Chen, Si-Yi Yu, Yi-Wen Qiu, Wei-Qi Gu, Xiao-Yu Chen, Yun Cui, Danfeng Sun, Zhan-Ju Liu, San-Jun Cai, Jie Xu, Ying-Xuan Chen, Jing-Yuan Fang
OBJECTIVE: Current non-invasive early detection of colorectal cancer (CRC) requires improvement. We aimed to identified a fecal Clostridium symbiosum-based biomarker for early and advanced colorectal cancer detection. DESIGN: In the test stage, the relative abundance of Clostridium symbiosum (C. symbiosum) was measured by qPCR in 781 cases including 242 controls, 212 colorectal adenoma (CRA) patients, 109 early CRC (tumor restricted to the submucosa) patients, 218 advanced CRC patients...
October 4, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29026618/a-case-of-polymicrobial-anaerobic-spondylodiscitis-due-to-parvimonas-micra-and-fusobacterium-nucleatum
#8
Leanne M Cleaver, Shara Palanivel, Damien Mack, Simon Warren
Introduction. Here, we present a case of polymicrobial anaerobic spondylodiscitis. Case Presentation. A forty-five year-old female patient was referred to a specialist orthopaedic hospital with an eight week history of back pain without fevers. X-ray imaging and magnetic resonance imaging showed acute osteomyelitis of the twelfth thoracic and first lumbar vertebrae. Prolonged enrichment cultures grew Parvimonas micra and Fusobacterium nucleatum, identified by matrix-assisted laser desorption ionisation-time of flight (MALDI-ToF) mass spectrometry (MS)...
April 2017: JMM Case Reports
https://www.readbyqxmd.com/read/29024797/nlrx1-modulates-differentially-nlrp3-inflammasome-activation-and-nf-%C3%AE%C2%BAb-signaling-during-fusobacterium-nucleatum-infection
#9
Shu-Chen Hung, Pei-Rong Huang, Cássio Luiz Coutinho Almeida-da-Silva, Kalina R Atanasova, Ozlem Yilmaz, David M Ojcius
NOD-like receptors (NLRs) play a large role in regulation of host innate immunity, yet their role in periodontitis remains to be defined. NLRX1, a member of the NLR family that localizes to mitochondria, enhances mitochondrial ROS (mROS) generation. mROS can activate the NLRP3 inflammasome, yet the role of NLRX1 in NLRP3 inflammasome activation has not been examined. In this study, we revealed the mechanism by which NLRX1 positively regulates ATP-induced NLRP3 inflammasome activation through mROS in gingival epithelial cells (GECs)...
October 9, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29021252/a-chemical-and-biological-toolbox-for-type-vd-secretion-characterization-of-the-phospholipase-a1-autotransporter-fpla-from-fusobacterium-nucleatum
#10
Michael A Casasanta, Christopher C Yoo, Hans B Smith, Alison J Duncan, Kyla Cochrane, Ann C Varano, Emma Allen-Vercoe, Daniel J Slade
Fusobacterium nucleatum is an oral pathogen that is linked to multiple human infections and colorectal cancer. Strikingly, F. nucleatum achieves virulence in the absence of large, multi-protein secretion systems (Type I, II, III, IV, and VI) which are widely used by Gram-negative bacteria for pathogenesis. By contrast, F. nucleatum strains contain genomic expansions of Type V secreted effectors (autotransporters) that are critical for host cell adherence, invasion, and biofilm formation. Here we present the first characterization of a F...
October 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29016688/tlr2-tlr4-activation-induces-tregs-and-suppresses-intestinal-inflammation-caused-by-fusobacterium-nucleatum-in-vivo
#11
Yin-Ping Jia, Kun Wang, Zhu-Jun Zhang, Ya-Nan Tong, Dan Han, Chun-Yu Hu, Qian Li, Yang Xiang, Xu-Hu Mao, Bin Tang
Toll-like receptors (TLRs) 2 and 4 play critical roles in intestinal inflammation caused by Fusobacterium nucleatum (F. nucleatum) infection, but the role of TLR2/TLR4 in regulation of proinflammatory cytokines remains unknown. In this study, through microarray analysis and qRT-PCR, we showed that TLR2/TLR4 are involved in the F. nucleatum-induced inflammatory signaling pathway in Caco-2 cells, C57BL/6 mice and human clinical specimens. In TLR2-/- and TLR4-/- mice, F. nucleatum infection resulted in increased colonization of the bacteria and production of the proinflammatory cytokines IL-8, IL-1β and TNF-α...
2017: PloS One
https://www.readbyqxmd.com/read/28987726/inhibition-of-malodorous-gas-formation-by-oral-bacteria-with-cetylpyridinium-and-zinc-chloride
#12
Jeong Hyun Kang, Dae Jeong Kim, Bong Kyu Choi, Ji Woon Park
OBJECTIVE: The antimicrobial efficacy of zinc- (ZnCl2) and cetylpyridinium-chloride (CPC) and their inhibition capacity on volatile sulfur compound (VSC) production by oral bacterial strains were investigated. DESIGN: Minimum inhibitory concentrations (MIC) and growth curves were determined for ZnCl2, CPC, and CPC with ZnCl2 solutions against eight oral microorganisms (Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella intermedia, Treponema denticola, Tannerella forsythia, Staphylococcus aureus and Streptococcus mutans) known to be involved in the pathophysiology of both halitosis and periodontal disease...
September 28, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28971271/association-between-high-risk-for-preterm-birth-and-changes-in-gingiva-parameters-during-pregnancy-a-prospective-cohort-study
#13
Anne Brigitte Kruse, Anja C Kuerschner, Mirjam Kunze, Johan P Woelber, Ali Al-Ahmad, Annette Wittmer, Kirstin Vach, Petra Ratka-Krueger
OBJECTIVES: The objective of this study was to investigate clinical and microbiological gingival changes during pregnancy in women without periodontal disease. Additionally, these parameters were to be compared in women with high risk for preterm birth and women with a normal course of pregnancy. METHOD AND MATERIALS: Group I consisted of 40 subjects at high risk for preterm birth, while group II involved 49 subjects with a normal course of pregnancy. The control group (III) was made up of 50 non-pregnant women...
October 2, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28967828/biological-evaluation-of-silver-nanoparticles-incorporated-into-chitosan-based-membranes
#14
Jinlong Shao, Na Yu, Eva Kolwijck, Bing Wang, Ke Wei Tan, John A Jansen, X Frank Walboomers, Fang Yang
AIM: To evaluate the antibacterial potential and biological performance of silver nanoparticles in chitosan-based membranes. MATERIALS & METHODS: Electrospun chitosan/poly(ethylene oxide) membranes with different amounts of silver nanoparticles were evaluated for antibacterial properties and cytotoxicity in vitro and for tissue response in a rabbit subcutaneous model. RESULTS: The nanoparticles displayed dose-dependent antibacterial properties against Porphyromonas gingivalis and Fusobacterium nucleatum, without showing noticeable cytotoxicity...
October 2, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28960881/interspecies-dynamics-among-bacteria-associated-with-canine-periodontal-disease
#15
P Sanguansermsri, A H Nobbs, H F Jenkinson, R Surarit
The etiology and pathogenic mechanisms associated with canine periodontal disease are less well understood than the disease in humans. In this study we have reconstructed defined consortia biofilms in vitro of microorganisms identified as prevalent in a same-breed cohort of dogs with or without periodontal disease. Frederiksenia canicola and Neisseria canis were selected as potential early colonizers of salivary pellicle, and Fusobacterium nucleatum and Porphyromonas gulae were included as high incidence canine oral bacteria...
September 28, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/28945671/microbial-leakage-at-morse-taper-conometric-prosthetic-connection-an-in-vitro-investigation
#16
Eriberto Bressan, Michele Stocchero, Ryo Jimbo, Claudio Rosati, Elena Fanti, Cristiano Tomasi, Diego Lops
OBJECTIVE: To evaluate in vitro the sealing capability at the prosthetic connection interface of 2 conometric systems. MATERIALS AND METHODS: Two conometric systems with the same design and different material were used, for a total of 24 samples. Each sample was assembled by a tapered abutment and respective coping. In group A, the copings were made of gold, whereas in group B they were made of PEEK. Three μL of mix bacterial suspension (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Fusobacterium nucleatum species) was inoculated into the abutment screw hole, and the coping was inserted on the abutment...
October 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28945499/complex-intratissue-microbiota-forms-biofilms-in-periodontal-lesions
#17
K Baek, S Ji, Y Choi
Periodontitis is caused by dysbiotic subgingival bacterial communities that may lead to increased bacterial invasion into gingival tissues. Although shifts in community structures associated with transition from health to periodontitis have been well characterized, the nature of bacteria present within the gingival tissue of periodontal lesions is not known. To characterize microbiota within tissues of periodontal lesions and compare them with plaque microbiota, gingival tissues and subgingival plaques were obtained from 7 patients with chronic periodontitis...
September 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28942408/asymptomatic-pyogenic-liver-abscesses-secondary-to-fusobacterium-nucleatum-and-streptococcus-vestibularis-in-an-immunocompetent-patient
#18
Hamish Houston, Kartik Kumar, Salman Sajid
A 66-year-old male patient presented with symptoms and signs of L4/5 radiculopathy. He was found to be anaemic with elevated inflammatory markers and deranged hepatic enzymes. Imaging revealed lumbar canal stenosis and the presence of pyogenic liver abscesses from which Fusobacterium nucleatum and Streptococcus vestibularis were isolated. The hepatic abscesses were attributed to asymptomatic diverticular perforation. Multiple coexisting incidental infections were discovered, including oesophageal candidiasis, Helicobacter pylori, stool cultures positive for Strongyloides stercoralis, and sputum cultures positive for Enterobacter cloacae, Escherichia coli and Mycobacterium avium Extensive investigations for possible underlying immunosuppression were negative...
September 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28914596/obesity-and-periodontitis-an-experimental-study-to-evaluate-the-periodontal-and-systemic-effects-of-the-co-morbidity
#19
Leire Virto, Pilar Cano, Vanesa Jiménez-Ortega, Pilar Fernández-Mateos, Jerián González, Ana Isabel Esquifino, Mariano Sanz
BACKGROUND: Obesity and overweight have been associated with periodontitis. This study aims to evaluate the periodontal and systemic effects of this association in a validated experimental model. METHODS: 28 male Wistar rats were randomly divided in four groups: control group (Con) (fed with standard diet); high-fat diet group (HFD) (fed with a diet containing 35.2% fat); control group with induced periodontitis (Con-Perio) and HFD group with induced periodontitis (HFD-Perio)...
September 15, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28912574/distinct-gut-microbiome-patterns-associate-with-consensus-molecular-subtypes-of-colorectal-cancer
#20
Rachel V Purcell, Martina Visnovska, Patrick J Biggs, Sebastian Schmeier, Frank A Frizelle
Colorectal cancer (CRC) is a heterogeneous disease and recent advances in subtype classification have successfully stratified the disease using molecular profiling. The contribution of bacterial species to CRC development is increasingly acknowledged, and here, we sought to analyse CRC microbiomes and relate them to tumour consensus molecular subtypes (CMS), in order to better understand the relationship between bacterial species and the molecular mechanisms associated with CRC subtypes. We classified 34 tumours into CRC subtypes using RNA-sequencing derived gene expression and determined relative abundances of bacterial taxonomic groups using 16S rRNA amplicon metabarcoding...
September 14, 2017: Scientific Reports
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