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Fusobacterium nucleatum

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https://www.readbyqxmd.com/read/28077337/stress-hormone-epinephrine-adrenaline-and-norepinephrine-noradrenaline-effects-on-the-anaerobic-bacteria
#1
REVIEW
Lyudmila Boyanova
Microbial endocrinology is a relatively new research area that already encompasses the anaerobes. Stress hormones, epinephrine and norepinephrine, can affect the growth of anaerobic bacteria such as Fusobacterium nucleatum, Prevotella spp., Porhyromonas spp., Tanerella forsythia and Propionibacterium acnes and can increase virulence gene expression, iron acquisition and many virulence factors of some anaerobic species such as Clostridium perfringens, Porphyromonas gingivalis and Brachyspira pilosicoli. Epinephrine and norepinephrine effects can lead to a growth increase or decrease, or no effect on the growth of the anaerobes...
January 8, 2017: Anaerobe
https://www.readbyqxmd.com/read/28050984/evaluation-of-bacteriological-profile-in-the-apical-root-segment-of-the-patients-with-primary-apical-periodontitis
#2
Aravind Tatikonda, N Sudheep, Krishna P Biswas, K Gowtham, Sudarshan Pujari, Padam Singh
INTRODUCTION: Apical periodontitis usually results from bacterial accumulation and contamination occurring in the root-canal system, and extending beyond the apical foramen to involve the periapical tissues. Literature has a paucity of the studies that stress on the division and analysis of the pulp canal segments. The reason for this disparity might be the technique used for collecting the samples from the pulp canals. Hence, we carried out the present study to evaluate the microbial flora in the apical part of the roots with necrotic pulp canals...
January 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28045107/collateral-damage-insights-into-bacterial-mechanisms-that-predispose-host-cells-to-cancer
#3
Aurélie Gagnaire, Bertrand Nadel, Didier Raoult, Jacques Neefjes, Jean-Pierre Gorvel
Infections are estimated to contribute to 20% of all human tumours. Viruses are known to induce cell transformation, but evidence has also linked bacteria, such as Helicobacter pylori and Salmonella enterica subsp. enterica serovar Typhi, to different cancer types. In addition, Chlamydia trachomatis, Fusobacterium nucleatum and Bacteroides fragilis are associated with the development of cancer, although a causal relationship has not yet been established. Bacterial effectors such as colibactin and the virulence factor cytotoxin-associated gene A (CagA) can promote cancer directly by influencing host cell signalling cascades, such as the WNT and ataxia-telangiectasia mutated (ATM) pathways, or indirectly by inducing tissue damage and inflammatory responses...
January 3, 2017: Nature Reviews. Microbiology
https://www.readbyqxmd.com/read/28034636/detection-of-fusobacterium-nucleatum-in-two-cases-of-empyema-and-lung-abscess-using-paromomycin-vancomycin-supplemented-brucella-hk-agar
#4
Kentaro Nagaoka, Katsunori Yanagihara, Yoshitomo Morinaga, Shigeru Kohno
Fusobacterium nucleatum was found in patients with empyema or pulmonary abscess, using paromomycin-vancomycin Brucella HK agar. In vitro examination revealed that growth of the strains differed significantly in different media. Clinicians should be aware that suboptimal F. nucleatum cultivation methods may result in an underestimation of its frequency.
December 26, 2016: Anaerobe
https://www.readbyqxmd.com/read/28013413/selective-persistence-of-propionibacterium-species-fma5-following-sealing-of-infected-dentinal-matrix
#5
M A Nadkarni, K Angner, N Hunter
The objective of the present study was to test the hypothesis that nutrient deprivation by effective isolation should inactivate causative saccharolytic bacteria occupying carious lesions. Vital maxillary third molar teeth were prepared by removing only the superficial necrotic material, leaving behind infected dentinal matrix, before the cavity was sealed with glass ionomer cement (GIC). Before sealing, lesions were biopsied to provide reference bacterial DNA for microbial analysis. After an interval of 10-12 months, the teeth were extracted and, after careful removal of GIC restoration, the underlying dentine was biopsied again for post-treatment microbial analysis...
December 24, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27999400/comparative-study-on-the-characteristics-of-weissella-cibaria-cmu-and-probiotic-strains-for-oral-care
#6
Hye-Jin Jang, Mi-Sun Kang, Sung-Hun Yi, Ji-Young Hong, Sang-Pil Hong
Probiotics have been demonstrated as a new paradigm to substitute antibiotic treatment for dental caries, gingivitis, and chronic periodontitis. The present work was conducted to compare the characteristics of oral care probiotics: Weissella cibaria CMU (Chonnam Medical University) and four commercial probiotic strains. Survival rates under poor oral conditions, acid production, hydrogen peroxide production, as well as inhibition of biofilm formation, coaggregation, antibacterial activity, and inhibition of volatile sulfur compounds were evaluated...
December 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27982490/rt-pcr-quantification-of-periodontal-pathogens-in-crack-users-and-non-users
#7
M Casarin, R P Antoniazzi, R A Vaucher, C A Feldens, F B Zanatta
OBJECTIVE: To compare counts of Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Porphyromonas gingivalis and Fusobacterium nucleatum between crack users and non-users. MATERIALS AND METHODS: A cross-sectional study was conducted involving seventy-four crack cocaine users and eighty-one non-users matched for age, gender and tobacco use. Demographic and clinical variables were analysed. Subgingival bacterial samples were collected from four sites with the greatest probing depths and were analysed using real-time polymerase chain reaction...
November 5, 2016: Oral Diseases
https://www.readbyqxmd.com/read/27982237/murine-experimental-root-canal-infection-cytokine-expression-in-response-to-f-nucleatum-and-e-faecalis
#8
Andressa Lamari Reis, Ricardo Reis Oliveira, Warley Luciano Fonseca Tavares, Thamyris Duque Silva Saldanha, Luiz de Macêdo Farias, Leda Quércia Vieira, Antônio Paulino Ribeiro
The aim of this study was to evaluate the gene expression of proinflammatory (RANKL, TNF-a and IFN-g) and regulatory (TGF-b and IL-10) cytokines as reaction to experimental infection by mono or bi-association of Fusobacterium nucleatum (ATCC 10953) and Enterococcus faecalis (ATCC 19433). F. nucleatum and E. faecalis, either in mono- or bi-association were inoculated into the root canal system (RCS) of Balb/c mice. Animals were sacrificed at 10 and 20 days after infection and periapical tissues surrounding the root were collected...
September 2016: Brazilian Dental Journal
https://www.readbyqxmd.com/read/27976528/streptococcus-mutans-spap-binds-to-radd-of-fusobacterium-nucleatum-ssp-polymorphum
#9
Lihong Guo, Bhumika Shokeen, Xuesong He, Wenyuan Shi, Renate Lux
Adhesin-mediated bacterial interspecies interactions are important elements in oral biofilm formation. They often occur on a species-specific level, which could determine health- or disease association of a biofilm community. Among the key players involved in these processes are the ubiquitous fusobacteria that have been recognized for their ability to interact with numerous different binding partners. Fusobacterial interactions with Streptococcus mutans, an important oral cariogenic pathogen, have previously been described but most studies focused on binding to non-mutans streptococci and specific cognate adhesin pairs remain to be identified...
December 15, 2016: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/27965635/photoinactivation-using-visible-light-plus-water-filtered-infrared-a-vis-wira-and-chlorine-e6-ce6-eradicates-planktonic-periodontal-pathogens-and-subgingival-biofilms
#10
Ali Al-Ahmad, Aleksander Walankiewicz, Elmar Hellwig, Marie Follo, Christian Tennert, Annette Wittmer, Lamprini Karygianni
Alternative treatment methods for pathogens and microbial biofilms are required due to the widespread rise in antibiotic resistance. Antimicrobial photodynamic therapy (aPDT) has recently gained attention as a novel method to eradicate pathogens. The aim of this study was to evaluate the antimicrobial effects of a novel aPDT method using visible light (vis) and water infiltrated infrared A (wIRA) in combination with chlorine e6 (Ce6) against different periodontal pathogens in planktonic form and within in situ subgingival oral biofilms...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27909688/the-danger-signal-extracellular-atp-is-an-inducer-of-fusobacterium-nucleatum-biofilm-dispersal
#11
Qinfeng Ding, Kai Soo Tan
Plaque biofilm is the primary etiological agent of periodontal disease. Biofilm formation progresses through multiple developmental stages beginning with bacterial attachment to a surface, followed by development of microcolonies and finally detachment and dispersal from a mature biofilm as free planktonic bacteria. Tissue damage arising from inflammatory response to biofilm is one of the hallmark features of periodontal disease. A consequence of tissue damage is the release of ATP from within the cell into the extracellular space...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27899684/high-risk-periodontal-pathogens-contribute-to-the-pathogenesis-of-atherosclerosis
#12
REVIEW
Bradley Field Bale, Amy Lynn Doneen, David John Vigerust
Periodontal disease (PD) is generated by microorganisms. These microbes can enter the general circulation causing a bacteraemia. The result can be adverse systemic effects, which could promote conditions such as cardiovascular disease. Level A evidence supports that PD is independently associated with arterial disease. PD is a common chronic condition affecting the majority of Americans 30 years of age and older. Atherosclerosis remains the largest cause of death and disability. Studies indicate that the adverse cardiovascular effects from PD are due to a few putative or high-risk bacteria: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola or Fusobacterium nucleatum There are three accepted essential elements in the pathogenesis of atherosclerosis: lipoprotein serum concentration, endothelial permeability and binding of lipoproteins in the arterial intima...
November 29, 2016: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/27898560/fusobacterium-nucleatum-an-unusual-cause-of-subdural-empyema
#13
Denise Yocum
This article describes an uncommon presentation of a subdural empyema in a young man. Because the patient's initial presentation consisted of nonspecific abdominal complaints, subdural empyema was not initially considered. However, a thorough medical history, including recent travel history, and appropriate multidisciplinary consultation, were key to reaching the correct diagnosis.
December 2016: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/27894820/quantitative-detection-of-periodontopathic-bacteria-in-lower-respiratory-tract-specimens-by-real-time-pcr
#14
Kentaro Nagaoka, Katsunori Yanagihara, Yosuke Harada, Koichi Yamada, Yohei Migiyama, Yoshitomo Morinaga, Koichi Izumikawa, Shigeru Kohno
The presence of common periodontopathic bacteria, the Fusobacterium nucleatum-periodonticum-simiae group, Prevotella intermedia, and Porphyromonas gingivalis was determined from respiratory tract specimens of bacterial pneumonia by real-time PCR using universal and species-specific TaqMan probe/primer sets. 42 patients with infectious pneumonia and 45 patients without infectious pneumonia were retrospectively enrolled in clinical studies. Periodontopathic bacterial DNA was found in 57.1% cases of infectious pneumonia and 31...
February 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27885964/porphyromonas-gingivalis-capsule-mediated-coaggregation-as-a-virulence-factor-in-mixed-infection-with-fusobacterium-nucleatum
#15
David Polak, Oren Ferdman, Yael Houri-Haddad
BACKGROUND: Porphyromonas gingivalis capsule enables evasion from phagocytosis, invasion of keratinocytes and bacterial survival. In mixed infection, the capsule also participates in coaggregation, which may lead to characteristic virulence not present in the mono-infection. The aim of the study was to evaluate the role of P.gingivalis capsule as a virulence factor in co-aggregated mixed infection with Fusobacterium nucleatum. METHODS: Mixed infections containing F...
November 25, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27876571/fusobacterium-nucleatum-increases-proliferation-of-colorectal-cancer-cells-and-tumor-development-in-mice-by-activating-tlr4-signaling-to-nf%C3%AE%C2%BAb-upregulating-expression-of-microrna-21
#16
Yongzhi Yang, Wenhao Weng, Junjie Peng, Leiming Hong, Lei Yang, Yuji Toiyama, Renyuan Gao, Minfeng Liu, Mingming Yin, Cheng Pan, Hao Li, Bomin Guo, Qingchao Zhu, Qing Wei, Mary-Pat Moyer, Ping Wang, Sanjun Cai, Ajay Goel, Huanlong Qin, Yanlei Ma
BACKGROUND & AIMS: Nearly 20% of the global cancer burden can be linked to infectious agents. Fusobacterium nucleatum promotes tumor formation by epithelial cells via unclear mechanisms. We aimed to identify microRNAs (miRNAs) induced by F nucleatum and evaluate their ability to promote colorectal carcinogenesis in mice. METHODS: Colorectal cancer (CRC) cell lines were incubated with F nucleatum or control reagents and analyzed in proliferation and would healing assays...
November 19, 2016: Gastroenterology
https://www.readbyqxmd.com/read/27859260/inducible-expression-of-a-disintegrin-and-metalloproteinase-8-in-chronic-periodontitis-and-gingival-epithelial-cells
#17
W P P Aung, P Chotjumlong, S Pata, P Montreekachon, C Supanchart, S Khongkhunthian, T Sastraruji, S Krisanaprakornkit
BACKGROUND AND OBJECTIVES: The expression of A Disintegrin and Metalloproteinase 8 (ADAM8) is associated with several inflammatory diseases. Elevated ADAM8 levels have been shown in gingival crevicular fluid of patients with chronic periodontitis. The objective of this study was to investigate ADAM8 expression in chronic periodontitis tissues compared with that in normal tissues. ADAM8 expression and its inductive mechanism were examined in human gingival epithelial cells (HGECs) and human gingival fibroblasts...
November 17, 2016: Journal of Periodontal Research
https://www.readbyqxmd.com/read/27828984/fusobacterium-nucleatum-induced-impairment-of-autophagic-flux-enhances-the-expression-of-proinflammatory-cytokines-via-ros-in-caco-2-cells
#18
Bin Tang, Kun Wang, Yin-Ping Jia, Pan Zhu, Yao Fang, Zhu-Jun Zhang, Xu-Hu Mao, Qian Li, Dong-Zhu Zeng
Fusobacterium nucleatum (F. nucleatum) plays a critical role in gastrointestinal inflammation. However, the exact mechanism by which F. nucleatum contributes to inflammation is unclear. In the present study, it was revealed that F. nucleatum could induce the production of proinflammatory cytokines (IL-8, IL-1β and TNF-α) and reactive oxygen species (ROS) in Caco-2 colorectal) adenocarcinoma cells. Furthermore, ROS scavengers (NAC or Tiron) could decrease the production of proinflammatory cytokines during F...
2016: PloS One
https://www.readbyqxmd.com/read/27811909/fusobacterium-nucleatum-in-colorectal-carcinoma-tissue-according-to-tumor-location
#19
Kosuke Mima, Yin Cao, Andrew T Chan, Zhi Rong Qian, Jonathan A Nowak, Yohei Masugi, Yan Shi, Mingyang Song, Annacarolina da Silva, Mancang Gu, Wanwan Li, Tsuyoshi Hamada, Keisuke Kosumi, Akiko Hanyuda, Li Liu, Aleksandar D Kostic, Marios Giannakis, Susan Bullman, Caitlin A Brennan, Danny A Milner, Hideo Baba, Levi A Garraway, Jeffrey A Meyerhardt, Wendy S Garrett, Curtis Huttenhower, Matthew Meyerson, Edward L Giovannucci, Charles S Fuchs, Reiko Nishihara, Shuji Ogino
OBJECTIVES: Evidence suggests a possible role of Fusobacterium nucleatum in colorectal carcinogenesis, especially in right-sided proximal colorectum. Considering a change in bowel contents and microbiome from proximal to distal colorectal segments, we hypothesized that the proportion of colorectal carcinoma enriched with F. nucleatum might gradually increase along the bowel subsites from rectum to cecum. METHODS: A retrospective, cross-sectional analysis was conducted on 1,102 colon and rectal carcinomas in molecular pathological epidemiology databases of the Nurses' Health Study and the Health Professionals Follow-up Study...
November 3, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27809921/effects-by-periodontitis-on-pristane-induced-arthritis-in-rats
#20
Kaja Eriksson, Erik Lönnblom, Gregory Tour, Anna Kats, Piotr Mydel, Pierre Georgsson, Catharina Hultgren, Nastya Kharlamova, Ulrika Norin, Jörgen Jönsson, Anna Lundmark, Annelie Hellvard, Karin Lundberg, Leif Jansson, Rikard Holmdahl, Tülay Yucel-Lindberg
BACKGROUND: An infection-immune association of periodontal disease with rheumatoid arthritis has been suggested. This study aimed to investigate the effect of pre-existing periodontitis on the development and the immune/inflammatory response of pristane-induced arthritis. METHODS: We investigated the effect of periodontitis induced by ligature placement and Porphyromonas gingivalis (P. gingivalis) infection, in combination with Fusobacterium nucleatum to promote its colonization, on the development of pristane-induced arthritis (PIA) in rats (Dark Agouti)...
November 3, 2016: Journal of Translational Medicine
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