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Fusobacterium nucleatum

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https://www.readbyqxmd.com/read/28223139/the-role-of-il-1-gene-polymorphisms-il1a-il1b-and-il1rn-as-a-risk-factor-in-unsuccessful-implants-retaining-overdentures
#1
Margarida Sampaio Fernandes, Paula Vaz, Ana Cristina Braga, João Carlos Sampaio Fernandes, Maria Helena Figueiral
PURPOSE: Implant-supported overdentures are an alternative predictable rehabilitation method that has a high impact on improving the patient's quality of life. However, some biological complications may interfere with the maintenance and survival of these overdenture implants. The goal of this article was to assess the factors that affect peri-implant success, through a hypothetical prediction model for biological complications of implant overdentures. METHODS: A retrospective observational, prevalence study was conducted in 58 edentulous Caucasian patients rehabilitated with implant overdentures...
February 17, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28199859/structure-of-the-lps-o-chain-from-fusobacterium-nucleatum-strain-10953-containing-sialic-acid
#2
Evgeny Vinogradov, Frank St Michael, Kiyonobu Homma, Ashu Sharma, Andrew D Cox
Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. Recently, it has been gaining attention as a potential causative agent for colorectal cancer and is strongly linked with pregnancy complications including pre-term and still births. Little is known about virulence factors of this organism and thus we have initiated studies to examine the bacterial surface glycochemistry. Consistent with a recent paper suggesting that F. nucleatum strain 10593 can synthesize sialic acid, a staining technique identified sialic acid on the bacterial surface...
January 28, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28198980/influence-of-glycemic-control-on-the-levels-of-subgingival-periodontal-pathogens-in-patients-with-generalized-chronic-periodontitis-and-type-2-diabetes
#3
Tamires Szeremeske Miranda, Magda Feres, Belén Retamal-Valdés, Paula Juliana Perez-Chaparro, Suellen Silva Maciel, Poliana Mendes Duarte
Objective: This study evaluated the influence of glycemic control on the levels and frequency of subgingival periodontal pathogens in patients with type 2 diabetes mellitus (DM) and generalized chronic periodontitis (ChP). Material and Methods: Fifty-six patients with generalized ChP and type 2 DM were assigned according to the levels of glycated hemoglobin (HbA1c) into one of the following groups: HbA1c<8% (n=28) or HbA1c≥8% (n=28). Three subgingival biofilm samples from sites with probing depth (PD)<5 mm and three samples from sites with PD≥5 mm were analyzed by quantitative Polymerase Chain Reaction (PCR) for the presence and levels of Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Eubacterium nodatum, Parvimona micra, Fusobacterium nucleatum ssp...
January 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28193569/analysis-of-the-expression-of-nlrp3-and-aim2-in-periapical-lesions-with-apical-periodontitis-and-microbial-analysis-outside-the-apical-segment-of-teeth
#4
Shujun Ran, Bin Liu, Shensheng Gu, Zhe Sun, Jingping Liang
OBJECTIVE: To detect the distribution and expression levels of the nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) and the absent in Melanoma 2 (AIM2) inflammasomes in periapical lesions and to analyse the possible microbial stimuli outside of teeth. DESIGN: The distribution of NLRP3 and AIM2 inflammasomes in sixteen periapical lesions was investigated by immunohistochemistry. Meanwhile, the relative gene expression levels of NLRP3 and AIM2 in sixteen periapical lesions and three health periodontal tissue were quantified by real-time polymerase chain reaction (PCR)...
February 6, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28186709/in-vitro-evaluation-of-the-biological-compatibility-and-antibacterial-activity-of-a-bone-substitute-material-consisting-of-silver-doped-hydroxyapatite-and-bio-oss-%C3%A2
#5
Jingjue Gong, Lei Yang, Qi He, Ting Jiao
This study evaluated biological compatibility and antibacterial activity of a bone substitute material consisting of silver-doped hydroxyapatite (AgHA) and Bio-Oss(®) with different mixture ratios in vitro and investigated its antibacterial mechanism. AgHA was synthesized by a chemical precipitation method. After characterization, AgHA was mixed with Bio-Oss(®) at three ratios: 1:1, 1:2, and 1:4 by weight. Then, Porphyromonas gingivalis (Pg) and Fusobacterium nucleatum (Fn) were used to test the antibacterial activity of the mixture...
February 10, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28173636/identification-and-characterization-of-a-novel-fusobacterium-nucleatum-adhesin-involved-in-physical-interaction-and-biofilm-formation-with-streptococcus-gordonii
#6
Bruno P Lima, Wenyuan Shi, Renate Lux
To successfully colonize the oral cavity, bacteria must directly or indirectly adhere to available oral surfaces. Fusobacterium nucleatum plays an important role in oral biofilm community development due to its broad adherence abilities, serving as a bridge between members of the oral biofilm that cannot directly bind to each other. In our efforts to characterize the molecular mechanisms utilized by F. nucleatum to physically bind to key members of the oral community, we investigated the involvement of F. nucleatum outer membrane proteins in its ability to bind to the pioneer biofilm colonizer, Streptococcus gordonii...
February 7, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28163049/fusobacterium-nucleatum-bacteremia-presenting-with-portal-vein-thrombosis-an-abdominal-lemierre-syndrome
#7
Joseph A Moore, Siayareh Rambally
No abstract text is available yet for this article.
February 2, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28154519/mining-the-proteome-of-fusobacterium-nucleatum-subsp-nucleatum-atcc-25586-for-potential-therapeutics-discovery-an-in-silico-approach
#8
Abdul Musaweer Habib, Md Saiful Islam, Md Sohel, Md Habibul Hasan Mazumder, Mohd Omar Faruk Sikder, Shah Md Shahik
The plethora of genome sequence information of bacteria in recent times has ushered in many novel strategies for antibacterial drug discovery and facilitated medical science to take up the challenge of the increasing resistance of pathogenic bacteria to current antibiotics. In this study, we adopted subtractive genomics approach to analyze the whole genome sequence of the Fusobacterium nucleatum, a human oral pathogen having association with colorectal cancer. Our study divulged 1,499 proteins of F. nucleatum, which have no homolog's in human genome...
December 2016: Genomics & Informatics
https://www.readbyqxmd.com/read/28143770/tumor-potentiating-mechanisms-of-fusobacterium-nucleatum-a%C3%A2-multifaceted-microbe
#9
EDITORIAL
Robert A Holt, Kyla Cochrane
No abstract text is available yet for this article.
January 28, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28135570/the-structure-of-the-lps-o-chain-of-fusobacterium-nucleatum-strain-25586-containing-two-novel-monosaccharides-2-acetamido-2-6-dideoxy-l-altrose-and-a-5-acetimidoylamino-3-5-9-trideoxy-gluco-non-2-ulosonic-acid
#10
Evgeny Vinogradov, Frank St Michael, Andrew D Cox
Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. Recently, it has been gaining attention as a potential causative agent for colorectal cancer and is strongly linked with pregnancy complications including pre-term and still births. Little is known about the virulence factors of this organism, and thus we have initiated studies to examine the bacterium's surface glycochemistry. We isolated lipopolysaccharide (LPS) from F. nucleatum strain 25586 and purified and performed structural analysis on the O-antigen polysaccharide...
January 9, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28131960/three-species-biofilm-model-onto-plasma-treated-titanium-implant-surface
#11
Adaias O Matos, Antônio P Ricomini-Filho, Thamara Beline, Erika S Ogawa, Bárbara E Costa-Oliveira, Amanda B de Almeida, Francisco H Nociti Junior, Elidiane C Rangel, Nilson C da Cruz, Cortino Sukotjo, Mathew T Mathew, Valentim A R Barão
In this study, titanium (Ti) was modified with biofunctional and novel surface by micro-arc oxidation (MAO) and glow discharge plasma (GDP) and we tested the development of a three-species periodontopatogenic biofilm onto the treated commercially-pure titanium (cpTi) surfaces. Machined and sandblasted surfaces were used as control group. Several techniques for surface characterizations and monoculture on bone tissue cells were performed. A multispecies biofilm composed of Streptococcus sanguinis, Actinomyces naeslundii and Fusobacterium nucleatum was developed onto cpTi discs for 16...
January 21, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28126355/effect-of-opposing-implant-prostheses-on-periodontal-pathogens-in-dentures-a-pilot-study
#12
Xiaodong Zhou, Mathew T Kattadiyil, Raydolfo M Aprecio, Xiaoli Liu, Wu Zhang, Yiming Li
STATEMENT OF PROBLEM: An understanding of the presence of periodontal pathogens in denture plaque is important for the treatment of patients with edentulism. However, current data are limited and inconclusive. PURPOSE: The purpose of this pilot clinical study was to investigate whether opposing implant prostheses affect the presence of periodontal pathogens in maxillary complete dentures. MATERIAL AND METHODS: Twenty adult participants were enrolled in the study...
January 23, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28125762/association-of-dietary-patterns-with-risk-of-colorectal-cancer-subtypes-classified-by-fusobacterium-nucleatum-in-tumor-tissue
#13
Raaj S Mehta, Reiko Nishihara, Yin Cao, Mingyang Song, Kosuke Mima, Zhi Rong Qian, Jonathan A Nowak, Keisuke Kosumi, Tsuyoshi Hamada, Yohei Masugi, Susan Bullman, David A Drew, Aleksandar D Kostic, Teresa T Fung, Wendy S Garrett, Curtis Huttenhower, Kana Wu, Jeffrey A Meyerhardt, Xuehong Zhang, Walter C Willett, Edward L Giovannucci, Charles S Fuchs, Andrew T Chan, Shuji Ogino
Importance: Fusobacterium nucleatum appears to play a role in colorectal carcinogenesis through suppression of the hosts' immune response to tumor. Evidence also suggests that diet influences intestinal F nucleatum. However, the role of F nucleatum in mediating the relationship between diet and the risk of colorectal cancer is unknown. Objective: To test the hypothesis that the associations of prudent diets (rich in whole grains and dietary fiber) and Western diets (rich in red and processed meat, refined grains, and desserts) with colorectal cancer risk may differ according to the presence of F nucleatum in tumor tissue...
January 26, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28111632/oral-microbiome-and-history-of-smoking-and-colorectal-cancer
#14
Ikuko Kato, Adrian A Vasquez, Gregory Moyerbrailean, Susan Land, Jun Sun, Ho-Sheng Lin, Jeffrey L Ram
BACKGROUND: The equilibrium of oral microbiome may be altered by environmental factors, including cigarette smoking. Several recent studies also suggest that oral pathogens causing periodontal disease, such as Fusobacterium nucleatum, are involved in pathogenesis of colorectal cancer. METHODS: For this study oral rinse DNA samples from 190 participants in a population-based case-control study for colorectal cancer were used to amplify a V3-V4 region of bacterial 16S rRNA gene...
October 2016: Journal of Epidemiological Research
https://www.readbyqxmd.com/read/28111388/antibacterial-efficacy-of-triple-layered-poly-lactic-co-glycolic-acid-nanoapatite-lauric-acid-guided-bone-regeneration-membrane-on-periodontal-bacteria
#15
Nur Najiha Saarani, Kalitheerta Jamuna-Thevi, Neelam Shahab, Hendra Hermawan, Syafiqah Saidin
A guided bone regeneration (GBR) membrane has been extensively used in the repair and regeneration of damaged periodontal tissues. One of the main challenges of GBR restoration is bacterial colonization on the membrane, constitutes to premature membrane degradation. Therefore, the purpose of this study was to investigate the antibacterial efficacy of triple-layered GBR membrane composed of poly(lactic-co-glycolic acid) (PLGA), nanoapatite (NAp) and lauric acid (LA) with two types of Gram-negative periodontal bacteria, Fusobacterium nucleatum and Porphyromonas gingivalis through a disc diffusion and bacterial count tests...
January 20, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28108235/the-use-of-bacteriophages-to-biocontrol-oral-biofilms
#16
Szymon P Szafrański, Andreas Winkel, Meike Stiesch
Infections induced by oral biofilms include caries, as well as periodontal, and peri-implant disease, and may influence quality of life, systemic health, and expenditure. As bacterial biofilms are highly resistant and resilient to conventional antibacterial therapy, it has been difficult to combat these infections. An innovative alternative to the biocontrol of oral biofilms could be to use bacteriophages or phages, the viruses of bacteria, which are specific, non-toxic, self-proliferating, and can penetrate into biofilms...
January 17, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28104616/sequential-colonization-of-periodontal-pathogens-in-induction-of-periodontal-disease-and-atherosclerosis-in-ldlrnull-mice
#17
Sasanka S Chukkapalli, Meena Easwaran, Mercedes F Rivera-Kweh, Irina M Velsko, Sriram Ambadapadi, Jiayin Dai, Hannu Larjava, Alexandra R Lucas, Lakshmyya Kesavalu
Periodontal disease (PD) and atherosclerotic vascular disease (ASVD) are both chronic inflammatory diseases with a polymicrobial etiology and have been epidemiologically associated. The purpose is to examine whether periodontal bacteria that infect the periodontium, can also infect vascular tissues and enhance pre-existing early aortic atherosclerotic lesions in LDLR(null) mice. Mice were orally infected with intermediate bacterial colonizer Fusobacterium nucleatum for the first 12 weeks followed by late bacterial colonizers (Porphyromonas gingivalis, Treponema denticola and Tannerella forsythia) for the remaining 12 weeks mimicking the human oral microbiota ecological colonization...
January 18, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28077337/stress-hormone-epinephrine-adrenaline-and-norepinephrine-noradrenaline-effects-on-the-anaerobic-bacteria
#18
REVIEW
Lyudmila Boyanova
Microbial endocrinology is a relatively new research area that already encompasses the anaerobes. Stress hormones, epinephrine and norepinephrine, can affect the growth of anaerobic bacteria such as Fusobacterium nucleatum, Prevotella spp., Porhyromonas spp., Tanerella forsythia and Propionibacterium acnes and can increase virulence gene expression, iron acquisition and many virulence factors of some anaerobic species such as Clostridium perfringens, Porphyromonas gingivalis and Brachyspira pilosicoli. Epinephrine and norepinephrine effects can lead to a growth increase or decrease, or no effect on the growth of the anaerobes...
January 8, 2017: Anaerobe
https://www.readbyqxmd.com/read/28050984/evaluation-of-bacteriological-profile-in-the-apical-root-segment-of-the-patients-with-primary-apical-periodontitis
#19
Aravind Tatikonda, N Sudheep, Krishna P Biswas, K Gowtham, Sudarshan Pujari, Padam Singh
INTRODUCTION: Apical periodontitis usually results from bacterial accumulation and contamination occurring in the root-canal system, and extending beyond the apical foramen to involve the periapical tissues. Literature has a paucity of the studies that stress on the division and analysis of the pulp canal segments. The reason for this disparity might be the technique used for collecting the samples from the pulp canals. Hence, we carried out the present study to evaluate the microbial flora in the apical part of the roots with necrotic pulp canals...
1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28045107/collateral-damage-insights-into-bacterial-mechanisms-that-predispose-host-cells-to-cancer
#20
Aurélie Gagnaire, Bertrand Nadel, Didier Raoult, Jacques Neefjes, Jean-Pierre Gorvel
Infections are estimated to contribute to 20% of all human tumours. Viruses are known to induce cell transformation, but evidence has also linked bacteria, such as Helicobacter pylori and Salmonella enterica subsp. enterica serovar Typhi, to different cancer types. In addition, Chlamydia trachomatis, Fusobacterium nucleatum and Bacteroides fragilis are associated with the development of cancer, although a causal relationship has not yet been established. Bacterial effectors such as colibactin and the virulence factor cytotoxin-associated gene A (CagA) can promote cancer directly by influencing host cell signalling cascades, such as the WNT and ataxia-telangiectasia mutated (ATM) pathways, or indirectly by inducing tissue damage and inflammatory responses...
February 2017: Nature Reviews. Microbiology
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