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Fusobacterium nucleatum

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https://www.readbyqxmd.com/read/28736715/a-case-of-liver-abscess-and-fusobacterium-septicemia
#1
Elham Rahmati, Rosemary C She, Brittany Kazmierski, P Jan Geiseler, Darren Wong
Fusobacterium species are well described as the causative pathogen in Lemierre's syndrome, a suppurative thrombophlebitis of the jugular vein. However, they are less recognized for a unique variant of Lemierre's syndrome presenting with invasive intraabdominal infection and associated portal vein thrombosis. We describe a case of Fusobacterium nucleatum with hepatic abscess and septic pylephlebitis.
2017: IDCases
https://www.readbyqxmd.com/read/28724342/periodontal-disease-and-intra-amniotic-complications-in-women-with-preterm-prelabor-rupture-of-membranes
#2
Vladimira Radochova, Ivana Kacerovska Musilova, Martin Stepan, Peter Vescicik, Radovan Slezak, Bo Jacobsson, Marian Kacerovsky
OBJECTIVE: Periodontal disease is frequently suggested as a possible causal factor for preterm delivery. The link between periodontal disease and preterm delivery is a possible translocation of periopathogenic bacteria to the placenta and amniotic fluid as well as a systemic response to this chronic inflammatory disease. However, there is a lack of information on whether there is an association between clinical periodontal status in women with preterm prelabor rupture of membranes (PPROM) and the presence of microbial invasion of the amniotic cavity (MIAC) and intra-amniotic inflammation (IAI)...
July 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28713780/tumor-targeting-by-fusobacterium-nucleatum-a-pilot-study-and-future-perspectives
#3
Jawad Abed, Naseem Maalouf, Lishay Parhi, Stella Chaushu, Ofer Mandelboim, Gilad Bachrach
Colorectal adenocarcinoma (CRC) is a common tumor with high mortality rates. Interestingly, CRC was found to be colonized by the oral anaerobic bacteria Fusobacterium nucleatum, which accelerates tumor progression and enables immune evasion. The CRC-specific colonization by fusobacteria is mediated through the recognition of tumor displayed Gal-GalNAc moieties by the fusobacterial Fap2 Gal-GalNAc lectin. Here, we show high Gal-GalNAc levels in additional adenocarcinomas including those found in the stomach, prostate, ovary, colon, uterus, pancreas, breast, lung, and esophagus...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28706760/bactericidal-effect-of-different-anti-microbial-agents-on-fusobacterium-nucleatum-biofilm
#4
Rupa Ashok, Arathi Ganesh, Kandaswamy Deivanayagam
INTRODUCTION: The root canal anatomy of the teeth is very complex. Complete debridement of the root canals is a challenge and is very important for the success of the root canal treatment. Hence, this study was done to find an effective irrigant which can be used during root canal treatment. OBJECTIVE: The bactericidal effect of a potential root canal irrigant was compared with two commonly used root canal irrigants against monoculture biofilm of a commercially available isolate of Fusobacterium nucleatum...
June 11, 2017: Curēus
https://www.readbyqxmd.com/read/28698865/comparisons-of-gut-microbiota-among-healthy-control-patients-with-conventional-adenoma-sessile-serrated-adenoma-and-colorectal-cancer
#5
Hyuk Yoon, Nayoung Kim, Ji Hyun Park, Yong Sung Kim, Jongchan Lee, Hyoung Woo Kim, Yoon Jin Choi, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Hyun Chae Jung
BACKGROUND: Studies on gut microbiota regarding colorectal carcinogenesis, including sessile serrated adenoma (SSA), have been scarce. The aim of this study is to investigate the role of mucosa-associated gut microbiota in the colorectal carcinogenesis. METHODS: We collected biopsy samples of normal rectal mucosa during colonoscopy from healthy control and patients with conventional adenoma, SSA, and colorectal cancer (CRC), respectively (n = 6). Pyrosequencing for 16S rRNA gene of bacteria was performed to compare gut microbiota...
June 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28691459/periodontal-microbioma-and-rheumatoid-arthritis-the-role-of-porhyromonas-gingivalis
#6
L Azzi, S Rania, R Vinci, F Spadari, F Croveri, C Scognamiglio, D Farronato, L Tettamanti, A Tagliabue, J Silvestre-Rangil, C Bellintani
Rheumatoid Arthritis is a disease, which can be described as an autoimmune response after molecular mimicry caused by infective agents. The current study aims at evaluating the correlation between Rhematoid Arthritis (RA) and Periodontal Disease (PD), with special attention to the microbioma detected in the gums. Thirty-four patients with RD were recruited into the current study. Among rheumatic parameters, Rheumatoid Factor (RF), anti-citrullinated protein antibody (CCP), HLA-BDR1 and DAS28 were collected...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28687946/genome-based-reclassification-of-fusobacterium-nucleatum-subspecies-at-the-species-level
#7
Joong-Ki Kook, Soon-Nang Park, Yun Kyong Lim, Eugene Cho, Eojin Jo, Hansung Roh, Yeseul Shin, Jayoung Paek, Hwa-Sook Kim, Hongik Kim, Jeong Hwan Shin, Young-Hyo Chang
Fusobacterium nucleatum is classified as four subspecies, subsp. nucleatum, polymorphum, vincentii, and animalis, based on DNA-DNA hybridization (DDH) patterns, phenotypic characteristics, and/or multilocus sequence analysis (MLSA). The gold standards for classification of bacterial species are DDH and 16S ribosomal RNA gene (16S rDNA) sequence homology. The thresholds of DDH and 16S rDNA similarity for delineation of bacterial species have been suggested to be >70 and 98.65%, respectively. Average nucleotide identity (ANI) and genome-to-genome distance (GGD) analysis based on genome sequences were recently introduced as a replacement for DDH to delineate bacterial species with ANI (95-96%) and GGD (70%) threshold values...
July 7, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28671508/investigation-of-a-novel-predictive-biomarker-profile-for-the-outcome-of-periodontal-treatment
#8
Sarhang S Gul, Gareth S Griffiths, Graham P Stafford, Mohammed I Al-Zubidi, Andrew Rawlinson, Charles W I Douglas
BACKGROUND: An ability to predict the response to conventional non-surgical treatment of a periodontal site would be advantageous. However, so far the biomarkers or tests devised to achieve this have lacked sensitivity. The aim of this study was to assess the ability of a novel combination of biomarkers to predict the outcome of treatment of patients with chronic periodontitis. METHODS: GCF and subgingival plaque were collected from 77 patients at 3 representative sites, 1 healthy (≤ 3mm) and 2 diseased (≥ 6mm) at baseline and at 3 and 6-months post treatment...
July 3, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28666877/microbial-analysis-of-root-canal-and-periradicular-lesion-associated-to-teeth-with-endodontic-failure
#9
R S Pereira, V A A Rodrigues, W T Furtado, S Gueiros, G S Pereira, M J Avila-Campos
The quantification of ten microorganisms at the root ends and in the surrounding periradicular lesions was performed. Thirty 3 mm samples root ends and 30 samples of the surrounding chronic periapical infection were collected during apical microsurgery. Samples were triturated, and the bacterial DNA was obtained. The bacterial quantification was performed by using the SYBR Green system. At least one microorganism was detected in all patients. In both the root end and periapical samples, Fusobacterium nucleatum (71...
June 27, 2017: Anaerobe
https://www.readbyqxmd.com/read/28651243/structure-of-the-lps-o-chain-from-fusobacterium-nucleatum-strain-12230
#10
Evgeny Vinogradov, Frank St Michael, Andrew D Cox
Fusobacterium nucleatum is an anaerobic bacterium found in the human mouth where it causes periodontitis. It was also found in colorectal cancer tissues and is linked with pregnancy complications, including pre-term and still births. Cell surface structures of the bacterium could be implicated in pathogenesis. Here we report the following structure of the lipopolysaccharide O-chain of F. nucleatum strain 12230: -6-α-d-Glc-4-β-d-GlcNHBu3NHBuA-3-β-d-QuiNAc4NABu- where ABu and HBu indicate (R)-3-aminobutanoyl and (R)-3-hydroxybutanoyl, respectively; all monosaccharides are in the pyranose form...
June 16, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28633639/fusobacterial-liver-abscess-a-case-report-and-review-of-the-literature
#11
Dilip Jayasimhan, Linus Wu, Paul Huggan
BACKGROUND: Fusobacteriae are facultative anaerobic gram-negative bacilli which cause a range of invasive infections, amongst which pyogenic liver abscesses are rare. We describe a case of Fusobacterium nucleatum liver abscess and review the relevant literature. CASE PRESENTATION: A 51-year-old lady presented with a 4-day history of abdominal pain, diarrhoea, fever, rigors, and lethargy. Imaging revealed an abscess which was drained. Cultures of the blood and abscess aspirate grew Fusobacterium nucleatum and Prevotella pleuritidis respectively...
June 20, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28606669/effectiveness-in-the-removal-of-endotoxins-and-microbiological-profile-in-primary-endodontic-infections-using-3-different-instrumentation-systems-a-randomized-clinical-study
#12
Daiana Cavalli, Cássia Cestari Toia, Esteban Isai Flores Orozco, Rayana Duarte Khoury, Flávia Goulart da Rosa Cardoso, Marcelo Corrêa Alves, Cláudio Antônio Talge Carvalho, Marcia Carneiro Valera
INTRODUCTION: This clinical study was conducted to correlate the microbiological profile and levels of endotoxins found in primary endodontic infection with the presence of clinical features and to evaluate the removal of microorganisms and endotoxins using rotary, reciprocating, and hybrid systems for biomechanical preparation. METHODS: Thirty single root canals with primary endodontic infection were evaluated with signs and symptoms and were randomly divided into 3 groups according to the instrumentation system used (n = 10) as follows: rotary Mtwo instruments (VDW, Munich, Germany) with 8 files, the reciprocating Reciproc system (VDW) with a single file, and Genius hybrid instruments with 3 files (1 rotary and 2 reciprocating files) with irrigation using 24 mL 2...
June 9, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28597080/intratumoral-fusobacterium-nucleatum-abundance-correlates-with-macrophage-infiltration-and-cdkn2a-methylation-in-microsatellite-unstable-colorectal-carcinoma
#13
Hye Eun Park, Jung Ho Kim, Nam-Yun Cho, Hye Seung Lee, Gyeong Hoon Kang
Fusobacterium nucleatum (Fn), a specific species of gut microbiota, has been suggested to be enriched in the microsatellite instability-high (MSI-H) molecular subtype of colorectal carcinomas (CRCs). However, the clinicopathologic and molecular factors that interact with Fn in MSI-H CRCs are poorly understood. In this study, 16S ribosomal RNA gene DNA sequence of Fn was quantitatively measured by real-time polymerase chain reaction in tumor DNA samples from a total of 160 surgically resected MSI-H CRC tissues...
June 8, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28587675/bactericidal-effects-of-310%C3%A2-nm-ultraviolet-light-emitting-diode-irradiation-on-oral-bacteria
#14
Ayuko Takada, Kenji Matsushita, Satoru Horioka, Yasushi Furuichi, Yasunori Sumi
BACKGROUND: Ultraviolet (UV) light is used for phototherapy in dermatology, and UVB light (around 310 nm) is effective for treatment of psoriasis and atopic dermatitis. In addition, it is known that UVC light (around 265 nm) has a bactericidal effect, but little is known about the bactericidal effect of UVB light. In this study, we examined the bactericidal effects of UVB-light emitting diode (LED) irradiation on oral bacteria to explore the possibility of using a 310 nm UVB-LED irradiation device for treatment of oral infectious diseases...
June 6, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28582482/fusobacterium-and-colorectal-cancer-causal-factor-or-passenger-results-from-a-large-colorectal-cancer-screening-study
#15
Efrat L Amitay, Simone Werner, Marius Vital, Dietmar H Pieper, Daniela Höfler, Indra-Jasmin Gierse, Julia Butt, Yesilda Balavarca, Katarina Cuk, Hermann Brenner
Colorectal cancer is a leading cause of morbidity and mortality worldwide in both men and women. The gut microbiome is increasingly recognized as having an important role in human health and disease. Fusobacterium has been identified in former studies as a leading gut bacterium associated with colorectal cancer but it is still not clear if it plays an oncogenic role. In the current study, fecal samples were collected prior to bowel preparation from participants of screening colonoscopy in the German BliTz study...
June 5, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28580924/crystal-structure-of-n-acetylmannosamine-kinase-from-fusobacterium-nucleatum
#16
Rhawnie Caing-Carlsson, Parveen Goyal, Amit Sharma, Swagatha Ghosh, Thanuja Gangi Setty, Rachel A North, Rosmarie Friemann, S Ramaswamy
Sialic acids comprise a varied group of nine-carbon amino sugars that are widely distributed among mammals and higher metazoans. Some human commensals and bacterial pathogens can scavenge sialic acids from their environment and degrade them for use as a carbon and nitrogen source. The enzyme N-acetylmannosamine kinase (NanK; EC 2.7.1.60) belongs to the transcriptional repressors, uncharacterized open reading frames and sugar kinases (ROK) superfamily. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate...
June 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28554609/biofilm-induced-changes-to-the-composite-surface
#17
Ivana Nedeljkovic, Jan De Munck, Andreea-Alexandra Ungureanu, Vera Slomka, Carmen Bartic, Anja Vananroye, Christian Clasen, Wim Teughels, Bart Van Meerbeek, Kirsten L Van Landuyt
OBJECTIVES: Composites may undergo biodegradation in the oral cavity. The objective was to investigate the effect of single- and multi-species biofilms on the surface roughness and topography of two composites. METHODS: Disk-shaped specimens of a paste-like, Bis-GMA-free (Gradia Direct Anterior, GC), and a flowable, Bis-GMA-based composite (Tetric EvoFlow, Ivoclar-Vivadent) were prepared. After ethylene-oxide sterilization (38°C), specimens (n=3) were incubated with Streptococcus mutans or mixed bacterial culture (Streptococcus mutans, Streptococcus sanguinis, Actinomyces naeslundii and Fusobacterium nucleatum)...
May 26, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28554093/new-bicyclic-brominated-furanones-as-potent-autoinducer-2-quorum-sensing-inhibitors-against-bacterial-biofilm-formation
#18
Ji Su Park, Eun-Ju Ryu, Linzi Li, Bong-Kyu Choi, B Moon Kim
Bacterial behaviors such as virulence factor secretion and biofilm formation are critical for survival, and are effectively regulated through quorum sensing, a mechanism of intra- and interspecies communication in response to changes in cell density and species complexity. Many bacterial species colonize host tissues and form a defensive structure called a biofilm, which can be the basis of inflammatory diseases. Periodontitis, a chronic inflammatory disease affecting the periodontium, is caused by subgingival biofilms related to periodontopathogens...
September 8, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28516038/detection-of-fusobacterium-nucleatum-in-culture-negative-brain-abscess-by-broad-spectrum-bacterial-16s-rrna-gene-pcr
#19
Catherine Chakvetadze, Anastasia Purcarea, Aurelia Pitsch, Jonathan Chelly, Sylvain Diamantis
BACKGROUND: Fusobacterium nucleatum is a strict anaerobic microorganism commensal to the human oropharynx and gastrointestinal tract, which causes a wide spectrum of human diseases and it is an important pathogen in abscesses. CASE PRESENTATION: We report the case of a previously healthy 64-year-old woman with multiple abscesses due to Fusobacterium nucleatum, involving liver, pleura and brain. Fusobacterium was not recovered from blood cultures nor from culture of hepatic, pleural and brain drain fluid...
2017: IDCases
https://www.readbyqxmd.com/read/28512280/herpes-simplex-1-and-periopathogen-role-in-peri-implantitis
#20
S Parthiban, Nizar Ahmed, T Ramakrishnan, V Balakumar, Manoj Raja, Himanshu Shekhar
INTRODUCTION: The objectives of this study were to compare the qualitative and quantitative profiles of herpes simplex virus type I (HSV-1) in implant surfaces between participants with peri-implantitis (PI) and Healthy peri-implant tissues and to quantitatively assess the relation between HSV-1 and periopathogens inside the microbiological profile associated with PI. MATERIALS AND METHODS: A total of 40 patients with PI and 40 with healthy peri-implant tissues (HI) were recruited...
May 1, 2017: Journal of Contemporary Dental Practice
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