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Violante Di Donato, Michele Carlo Schiavi, Ilary Ruscito, Virginia Sibilla Visentin, Innocenza Palaia, Claudia Marchetti, Margherita Fischetti, Marco Monti, Ludovico Muzii, Pierluigi Benedetti Panici
BACKGROUND: To assess the clinical efficacy and prognostic outcome of neoadjuvant chemotherapy (NACT) plus radical surgery (RS) as front line treatment in patients with FIGO stage III cervical cancer (CC). METHODS: In this retrospective study, 52 FIGO stage III CC patients treated from 2005 to 2015 were included. All patients received platinum-based chemotherapy. Patients reporting clinical response or stable disease after NACT underwent to RS and bilateral systematic pelvic lymphadenectomy with or without aortic lymphadenectomy or anterior exenteration...
September 27, 2016: Annals of Surgical Oncology
Santiago Bordera, Marina Mazón, Ilari E Sääksjärvi
We describe three new species of parasitoid wasps of the genus Atractodes (Ichneumonidae: Cryptinae) from South America: A. colchaguensis sp. nov. from Chile, and A. pleuripunctatus sp. nov. and A. saragurensis sp. nov. from Ecuador. These species are all characterized by a densely and strongly punctate mesopleuron. The Atractodes pleuripunctatus species-group is defined to accommodate the new species. In addition, the second part of the key to species of the Neotropical Atractodes including this species-group is given...
2016: Zootaxa
Niclas R Fritzén, Ilari E Sääksjärvi
Apical serrations of the hymenopteran ovipositor have been widely postulated to originally constitute adaptations for cutting through hard substrates. Simplifications of the ovipositor tip have occurred in several ichneumonid wasp genera associated with spiders. Despite such reduction in Clistopyga (Hymenoptera, Ichneumonidae), the ovipositor still possesses some apical serrations. Through the first detailed study, we believe, on the behaviour of an ovipositing Clistopyga species, we show that it can alter its ovipositor for different purposes and that the primary function of the apical serrations is clinging to its spider host as the spider attempts to escape...
August 2016: Biology Letters
Santiago Bordera, Marina Mazón, Ilari E Sääksjärvi
The Neotropical species of the cryptine genus Atractodes are studied, and four species-groups are proposed. In this paper, A. altoandinus and A. propodeator species-groups are diagnosed. The former species-group occurs from southern Mexico to Brazil and includes some of the largest Atractodes species ever found, all possessing a strongly sloped propodeum; the latter species-group is only known from the Chilean Andes and includes one of the smallest species of Atractodes, characterised by a very short and curved tergite I and short first flagellomere...
2016: Zootaxa
Desislava Dimitrova, Ilary Ruscito, Sven Olek, Rolf Richter, Alexander Hellwag, Ivana Türbachova, Hannah Woopen, Udo Baron, Elena Ioana Braicu, Jalid Sehouli
Germline mutations in BRCA1 gene have been reported in up to 20 % of epithelial ovarian cancer (EOC) patients. Distinct clinical characteristics have been attributed to this special EOC population. We hypothesized that mutations in different BRCA1 gene exons may differently affect the clinical course of the disease. The aim of this study was to analyze, in a large cohort of primary EOCs, the clinical impact of mutations in BRCA1 gene exon 11, the largest exon of the gene sequence encoding the 60 % of BRCA1 protein...
June 14, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Miia Artama, Eerik T Skyttä, Heini Huhtala, Mikko Leino, Ilari Kuitunen, Antti Eskelinen
Background and purpose - There have been few studies on the effect of THR on pregnancy or delivery, and they have mainly been based on small and regional data. We evaluated the birth rate nationwide in patients of fertile age with THR. Patients and methods - This nationwide population-based cohort study was based on registry data on 5,863 Finnish THR patients who had undergone a THR between 1985 and 2006, and who were aged 15-45 years (females) or 15-50 years (males) at the time of THR. The matched reference cohort consisted of 17,575 sex- and age-matched individuals (3 for each patient) who were alive and resident in Finland at the time of the patient's THR...
October 2016: Acta Orthopaedica
Filomena Lauro, Luigino Antonio Giancotti, Sara Ilari, Concetta Dagostino, Micaela Gliozzi, Chiara Morabito, Valentina Malafoglia, William Raffaeli, Maurizio Muraca, Bianca M Goffredo, Vincenzo Mollace, Carolina Muscoli
Citrus Bergamia Risso, commonly known as Bergamot, is a fruit whose Essential Oil and Bergamot Polyphenolic Fraction have numerous medicinal properties. It is also an excellent antioxidant and in this study, for the first time, its potential effect on morphine induced tolerance in mice has been investigated. Our studies revealed that development of antinociceptive tolerance to repeated doses of morphine in mice is consistently associated with increased formation of superoxide, malondialdehyde and tyrosine-nitrated proteins in the dorsal horn of the spinal cord such as the enzyme glutamine synthase...
2016: PloS One
Ilary Allodi, Laura Comley, Susanne Nichterwitz, Monica Nizzardo, Chiara Simone, Julio Aguila Benitez, Ming Cao, Stefania Corti, Eva Hedlund
The fatal disease amyotrophic lateral sclerosis (ALS) is characterized by the loss of somatic motor neurons leading to muscle wasting and paralysis. However, motor neurons in the oculomotor nucleus, controlling eye movement, are for unknown reasons spared. We found that insulin-like growth factor 2 (IGF-2) was maintained in oculomotor neurons in ALS and thus could play a role in oculomotor resistance in this disease. We also showed that IGF-1 receptor (IGF-1R), which mediates survival pathways upon IGF binding, was highly expressed in oculomotor neurons and on extraocular muscle endplate...
2016: Scientific Reports
Irene Della Starza, Vittorio Nunes, Marzia Cavalli, Lucia Anna De Novi, Caterina Ilari, Valerio Apicella, Antonella Vitale, Anna Maria Testi, Ilaria Del Giudice, Sabina Chiaretti, Robin Foà, Anna Guarini
Real-time quantitative polymerase chain reaction (RQ-PCR) is a standardized tool for minimal residual disease (MRD) monitoring in acute lymphoblastic leukaemia (ALL). The applicability of this technology is limited by the need of a standard curve based on diagnostic DNA. The digital droplet PCR (ddPCR) technology has been recently applied to various medical fields, but its use in MRD monitoring is under investigation. In this study, we analysed 50 ALL cases by both methods in two phases: in the first, we established analytical parameters to investigate the applicability of this new technique; in the second, we analysed MRD levels in 141 follow-up (FU) samples to investigate the possible use of ddPCR for MRD monitoring in ALL patients...
August 2016: British Journal of Haematology
Ilary Ruscito, Maria Luisa Gasparri, Elena Ioana Braicu, Filippo Bellati, Luigi Raio, Jalid Sehouli, Michael D Mueller, Pierluigi Benedetti Panici, Andrea Papadia
BACKGROUND: Historically, blue dyes, (99)Tc or a combination of the two tracers have been used for sentinel lymph node (SLN) mapping in cervical and endometrial cancer patients. Indocyanine green (ICG), as a tracer, has been recently introduced in this setting. Our goal was to assess the differences in overall and bilateral detection rates as well as in false-negative rates among the different tracers. METHODS: The electronic databases PubMed, MEDLINE, and Scopus were searched in January 2016 by searching the terms "sentinel lymph node" and "dye" and "indocyanine green," and "cervical cancer" or "endometrial cancer...
October 2016: Annals of Surgical Oncology
Ernestina Saulle, Alessia Petronelli, Elvira Pelosi, Elena Coppotelli, Luca Pasquini, Ramona Ilari, Francesco Lo-Coco, Ugo Testa
BACKGROUND: Recent studies indicate that angiogenesis is important in the pathogenesis of acute myeloid leukemias (AMLs). Among the various AMLs, the bone marrow angiogenetic response is particularly pronounced in acute promyelocytic leukemia (APL). However, the molecular mechanisms responsible for this angiogenetic response are largely unknown. In the present study, we have explored the role of HHEX, a homeodomain transcription factor, as a possible mediator of the pro-angiogenetic response observed in APL...
2016: Journal of Hematology & Oncology
Jani J Sormunen, Ritva Penttinen, Tero Klemola, Jari Hänninen, Ilppo Vuorinen, Maija Laaksonen, Ilari E Sääksjärvi, Kai Ruohomäki, Eero J Vesterinen
BACKGROUND: Ixodes ricinus and Ixodes persulcatus are the main vectors of Lyme borreliosis spirochetes and several other zoonotic bacteria in northern Europe and Russia. However, few studies screening bacterial pathogens in Finnish ticks have been conducted. Therefore, reports on the occurrence and prevalence of several bacterial pathogens detected from ticks elsewhere in Europe and Russia are altogether missing from Finland. The main aim of the current study was to produce novel data on the occurrence and prevalence of several tick-borne bacterial pathogens in ticks collected from southwestern Finland...
2016: Parasites & Vectors
Markku Partinen, Anne Huutoniemi, Soili Kajaste, Rea Lagerstedt, Juha Markkula, Erkki Mäkinen, Ilari Paakkari, Timo Partonen, Päivi Polo, Outi Saarenpää-Heikkilä, Maaria Seppälä, Katriina Kukkonen-Harjula, Arja Tuunainen
Insomnia symptoms must be differentiated from insomnia disorder. The correct aiagnosis or insomnia aisoraer is important, as insomnia may also be a symptom of many other diseases. Cognitive behavioral methods are recommended as first-line treatment options. Treatment of acute insomnia with hypnotics should not exceed two weeks. In elderly persons adverse effects of hypnotics may exceed their beneficial effects in long-term use. Antidepressive medications acting on the histamine-1 system may be used in very small doses...
2016: Duodecim; Lääketieteellinen Aikakauskirja
Marilisa Marinelli, Caterina Ilari, Yi Xia, Ilaria Del Giudice, Luciana Cafforio, Irene Della Starza, Sara Raponi, Paola Mariglia, Silvia Bonina, Zhen Yu, Wenjuan Yang, Lugui Qiu, Thomas Chan, Alfonso Piciocchi, Yok-Lam Kwong, Eric Tse, Jianyong Li, Anna Guarini, Wei Xu, Robin Foà
Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in the Western world, whereas in Asia the incidence is about 10 times lower. The basis for this ethnic and geographic variation is currently unknown. The aim of this study was to characterize IGHVDJ rearrangements and stereotype of the HCDR3 region in a series of 623 Chinese CLL, in order to identify possible differences in immunoglobulin gene usage and their potential pathogenetic implications. Chinese CLL were compared to 789 Italian CLL...
April 12, 2016: Oncotarget
Veronica Kalhori, Melissa Magnusson, Muhammad Yasir Asghar, Ilari Pulli, Kid Törnquist
The bioactive lipid sphingosine-1-phosphate (S1P) is a potent inducer of ML-1 thyroid cancer cell migration and invasion. It evokes migration and invasion by activating S1P receptor 1 and 3 (S1P1,3) and downstream signaling intermediates as well as through cross-communication with vascular endothelial growth factor receptor 2 (VEGFR2). However, very little is known about the role of S1P receptors in thyroid cancer. Furthermore, the currently used treatments for thyroid cancer have proven to be rather unsuccessful...
May 2016: Endocrine-related Cancer
Gabriele M Ilari, Vipin Chawla, Santhosh Matam, Yucheng Zhang, Johann Michler, Rolf Erni
The presented scanning transmission electron microscopy (STEM) and electron energy-loss spectroscopy (EELS) results show the strong reaction of Cr and V with the graphitic walls of MWCNTs. For Vanadium, an interfacial VC layer could be observed at the interface between VN and MWCNTs, when the samples were heated in situ to 750°C. Knowledge about this interfacial VC layer is important for the formation of VN-MWCNT hybrid materials, used in supercapacitor electrodes, often synthesized at high temperatures. Chromium reacts at 500°C with the MWCNTs to form Cr3C2 and in some cases, dissolved the MWCNT completely...
May 2016: Micron: the International Research and Review Journal for Microscopy
Morena Antonilli, Hassan Rahimi, Valeria Visconti, Chiara Napoletano, Ilary Ruscito, Ilaria Grazia Zizzari, Salvatore Caponnetto, Giacomo Barchiesi, Roberta Iadarola, Luca Pierelli, Aurelia Rughetti, Filippo Bellati, Pierluigi Benedetti Panici, Marianna Nuti
Vaccination with priming and expansion of tumour reacting T cells is an important therapeutic option to be used in combination with novel checkpoint inhibitors to increase the specificity of the T cell infiltrate and the efficacy of the treatment. In this phase I/II study, 14 high-risk disease-free ovarian (OC) and breast cancer (BC) patients after completion of standard therapies were vaccinated with MUC1, ErbB2 and carcinoembryonic antigen (CEA) HLA-A2+-restricted peptides and Montanide. Patients were subjected to 6 doses of vaccine every two weeks and a recall dose after 3 months...
April 2016: International Journal of Oncology
Sanna Oikari, Katri Makkonen, Ashik Jawahar Deen, Ilari Tyni, Riikka Kärnä, Raija H Tammi, Markku I Tammi
UDP-N-acetylglucosamine (UDP-GlcNAc) is a glucose metabolite with pivotal functions as a key substrate for the synthesis of glycoconjugates like hyaluronan, and as a metabolic sensor that controls cell functions through O-GlcNAc modification of intracellular proteins. However, little is known about the regulation of hexosamine biosynthesis that controls UDP-GlcNAc content. Four enzymes can catalyze the crucial starting point of the pathway, conversion of fructose-6-phosphate (Fru6P) to glucosamine-6-phosphate (GlcN6P): glutamine-fructose-6-phosphate aminotransferases (GFAT1 and 2) and glucosamine-6-phosphate deaminases (GNPDA1 and 2)...
July 2016: Glycobiology
Thomas Gicquel, Sacha Robert, Tatiana Victoni, Vincent Lagente
The innate immune system constitutes the first line of host defense against pathogens. "Nonself", such as exogenous particles or pathogens, triggers an inflammatory response. Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as IL-1β. Activation of the NLRP3 inflammasome pathway, the most extensively studied, appears to be the corner stone of many inflammatory diseases, including Crohn's disease, rheumatoid arthritis and gout...
April 2016: La Presse Médicale
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