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https://www.readbyqxmd.com/read/28199100/complexes-of-magnetic-nanoparticles-with-cellulose-nanocrystals-as-regenerable-highly-efficient-and-selective-platform-for-protein-separation
#1
Jiaqi Guo, Ilari Filpponen, Leena-Sisko Johansson, Pezhman Mohammadi, Mika Latikka, Markus B Linder, Robin H A Ras, Orlando J Rojas
We present an efficient approach to synthesize cellulose nanocrystal (CNC) hybrids with magnetically responsive Fe3O4 nanoparticles that were synthesized using the (Fe3+/Fe2+) co-precipitation. After TEMPO-catalyzed oxidation of CNC, carbodiimide (EDC/NHS) was used for coupling amine-containing iron oxide nanoparticles that were achieved by dopamine ligand exchange (NH2-Fe3O4 NPs). The as prepared hybrids (Fe3O4@CNC) were further complexed with Cu(II) ions to produce specific protein binding sites. The performance of magnetically responsive Cu-Fe3O4@CNC hybrid was assessed by selectively separating lysozyme from aqueous media...
February 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28174518/assessing-music-perception-in-young-children-evidence-for-and-psychometric-features-of-the-m-factor
#2
Caio G Barros, Walter Swardfager, Sylvain Moreno, Graziela Bortz, Beatriz Ilari, Andrea P Jackowski, George Ploubidis, Todd D Little, Alexandra Lamont, Hugo Cogo-Moreira
Given the relationship between language acquisition and music processing, musical perception (MP) skills have been proposed as a tool for early diagnosis of speech and language difficulties; therefore, a psychometric instrument is needed to assess music perception in children under 10 years of age, a crucial period in neurodevelopment. We created a set of 80 musical stimuli encompassing seven domains of music perception to inform perception of tonal, atonal, and modal stimuli, in a random sample of 1006 children, 6-13 years of age, equally distributed from first to fifth grades, from 14 schools (38% private schools) in So Paulo State...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28098499/inhibition-of-leishmania-infantum-trypanothione-reductase-by-diaryl-sulfide-derivatives
#3
Francesco Saccoliti, Gabriella Angiulli, Giovanni Pupo, Luca Pescatori, Valentina Noemi Madia, Antonella Messore, Gianni Colotti, Annarita Fiorillo, Luigi Scipione, Marina Gramiccia, Trentina Di Muccio, Roberto Di Santo, Roberta Costi, Andrea Ilari
The study presented here aimed at identifying a new class of compounds acting against Leishmania parasites, the causative agent of Leishmaniasis. For this purpose, the thioether derivatives of our in-house library have been evaluated in whole-cell screening assays in order to determine their in vitro activity against Leishmania protozoan. Among them, promising results have been achieved with compound RDS 777 (6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine) (IC50 = 29.43 µM), which is able to impair the mechanism of the parasite defence against the reactive oxygen species by inhibiting the trypanothione reductase (TR) with high efficiency (Ki 0...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/27994480/combining-pain-therapy-with-lifestyle-the-role-of-personalized-nutrition-and-nutritional-supplements-according-to-the-simpar-feed-your-destiny-approach
#4
REVIEW
Manuela De Gregori, Carolina Muscoli, Michael E Schatman, Tiziana Stallone, Fabio Intelligente, Mariangela Rondanelli, Francesco Franceschi, Laura Isabel Arranz, Silvia Lorente-Cebrián, Maurizio Salamone, Sara Ilari, Inna Belfer, Massimo Allegri
Recently, attention to the lifestyle of patients has been rapidly increasing in the field of pain therapy, particularly with regard to the role of nutrition in pain development and its management. In this review, we summarize the latest findings on the role of nutrition and nutraceuticals, microbiome, obesity, soy, omega-3 fatty acids, and curcumin supplementation as key elements in modulating the efficacy of analgesic treatments, including opioids. These main topics were addressed during the first edition of the Study In Multidisciplinary Pain Research workshop: "FYD (Feed Your Destiny): Fighting Pain", held on April 7, 2016, in Rome, Italy, which was sponsored by a grant from the Italian Ministry of Instruction on "Nutraceuticals and Innovative Pharmacology"...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27960438/superhydrophobic-and-slippery-lubricant-infused-flexible-transparent-nanocellulose-films-by-photoinduced-thiol-ene-functionalization
#5
Jiaqi Guo, Wenwen Fang, Alexander Welle, Wenqian Feng, Ilari Filpponen, Orlando J Rojas, Pavel A Levkin
Films comprising nanofibrillated cellulose (NFC) are suitable substrates for flexible devices in analytical, sensor, diagnostic, and display technologies. However, some major challenges in such developments include their high moisture sensitivity and the complexity of current methods available for functionalization and patterning. In this work, we present a facile process for tailoring the surface wettability and functionality of NFC films by a fast and versatile approach. First, the NFC films were coated with a layer of reactive nanoporous silicone nanofilament by polycondensation of trichlorovinylsilane (TCVS)...
December 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27957878/polyamine-trypanothione-pathway-an-update
#6
Andrea Ilari, Annarita Fiorillo, Ilaria Genovese, Gianni Colotti
In trypanosomatids, polyamine and trypanothione pathways can be considered as a whole unique metabolism, where most enzymes are essential for parasitic survival and infectivity. Leishmania parasites and all the other members of the Trypanosomatids family depend on polyamines for growth and survival: the enzymes involved in the synthesis and utilization of spermidine and trypanothione, i.e., arginase, ornithine decarboxylase, S-adenosylmethionine decarboxylase, spermidine synthase and in particular trypanothione synthetase-amidase, trypanothione reductase and tryparedoxin-dependent peroxidase are promising targets for drug development...
January 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/27932074/distributed-neural-signatures-of-natural-audiovisual-speech-and-music-in-the-human-auditory-cortex
#7
Juha Salmi, Olli-Pekka Koistinen, Enrico Glerean, Pasi Jylänki, Aki Vehtari, Iiro P Jääskeläinen, Sasu Mäkelä, Lauri Nummenmaa, Katarina Nummi-Kuisma, Ilari Nummi, Mikko Sams
During a conversation or when listening to music, auditory and visual information are combined automatically into audiovisual objects. However, it is still poorly understood how specific type of visual information shapes neural processing of sounds in lifelike stimulus environments. Here we applied multi-voxel pattern analysis to investigate how naturally matching visual input modulates supratemporal cortex activity during processing of naturalistic acoustic speech, singing and instrumental music. Bayesian logistic regression classifiers with sparsity-promoting priors were trained to predict whether the stimulus was audiovisual or auditory, and whether it contained piano playing, speech, or singing...
December 5, 2016: NeuroImage
https://www.readbyqxmd.com/read/27896717/a-practical-approach-to-protein-crystallography
#8
Andrea Ilari, Carmelinda Savino
Macromolecular crystallography is a powerful tool for structural biology. The resolution of a protein crystal structure is becoming much easier than in the past, thanks to developments in computing, automation of crystallization techniques and high-flux synchrotron sources to collect diffraction datasets. The aim of this chapter is to provide practical procedures to determine a protein crystal structure, illustrating the new techniques, experimental methods, and software that have made protein crystallography a tool accessible to a larger scientific community...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27803704/peroxidases-bound-to-the-growing-lignin-polymer-produce-natural-like-extracellular-lignin-in-a-cell-culture-of-norway-spruce
#9
Tino Warinowski, Sanna Koutaniemi, Anna Kärkönen, Ilari Sundberg, Merja Toikka, Liisa Kaarina Simola, Ilkka Kilpeläinen, Teemu H Teeri
Lignin, an important component of plant cell walls, is a polymer of monolignols derived from the phenylpropanoid pathway. Monolignols are oxidized in the cell wall by oxidative enzymes (peroxidases and/or laccases) to radicals, which then couple with the growing lignin polymer. We have investigated the characteristics of the polymerization reaction by producing lignin polymers in vitro using different oxidative enzymes and analyzing the structures formed with NMR. The ability of the enzymes to oxidize high-molecular-weight compounds was tested using cytochrome c as a substrate...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27798870/immunological-and-clinical-impact-of-cancer-stem-cells-in-vulvar-cancer-role-of-cd133-cd24-abcg2-expressing-cells
#10
MULTICENTER STUDY
Chiara Napoletano, Filippo Bellati, Ilary Ruscito, Milena Pernice, Ilaria Grazia Zizzari, Salvatore Caponnetto, Federica Tomao, Luigi Frigerio, Marco Liberati, Aurelia Rughetti, Donatella Caserta, Pierluigi Benedetti Panici, Marianna Nuti
BACKGROUND: Cancer stem cells (CSCs) are tumour-initiating cells with self-renewal properties and chemo/radio-resistance. Regulatory T-cells (Tregs) influence CSCs through several mechanisms. In different solid tumours, the presence of both cell populations correlated with poor survival. In vulvar cancer, little is known regarding biological markers able to predict patient prognosis. We investigated the presence and clinical impact of CSCs and infiltrating Treg in primary vulvar cancer...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27678502/effects-of-neoadjuvant-chemotherapy-plus-radical-surgery-as-front-line-treatment-strategy-in-patients-affected-by-figo-stage-iii-cervical-cancer
#11
Violante Di Donato, Michele Carlo Schiavi, Ilary Ruscito, Virginia Sibilla Visentin, Innocenza Palaia, Claudia Marchetti, Margherita Fischetti, Marco Monti, Ludovico Muzii, Pierluigi Benedetti Panici
BACKGROUND: To assess the clinical efficacy and prognostic outcome of neoadjuvant chemotherapy (NACT) plus radical surgery (RS) as front line treatment in patients with FIGO stage III cervical cancer (CC). METHODS: In this retrospective study, 52 FIGO stage III CC patients treated from 2005 to 2015 were included. All patients received platinum-based chemotherapy. Patients reporting clinical response or stable disease after NACT underwent to RS and bilateral systematic pelvic lymphadenectomy with or without aortic lymphadenectomy or anterior exenteration...
December 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27615943/the-neotropical-species-of-atractodes-hymenoptera-ichneumonidae-cryptinae-ii-the-a-pleuripunctatus-species-group
#12
Santiago Bordera, Marina Mazón, Ilari E Sääksjärvi
We describe three new species of parasitoid wasps of the genus Atractodes (Ichneumonidae: Cryptinae) from South America: A. colchaguensis sp. nov. from Chile, and A. pleuripunctatus sp. nov. and A. saragurensis sp. nov. from Ecuador. These species are all characterized by a densely and strongly punctate mesopleuron. The Atractodes pleuripunctatus species-group is defined to accommodate the new species. In addition, the second part of the key to species of the Neotropical Atractodes including this species-group is given...
September 6, 2016: Zootaxa
https://www.readbyqxmd.com/read/27512134/spider-silk-felting-functional-morphology-of-the-ovipositor-tip-of-clistopyga-sp-ichneumonidae-reveals-a-novel-use-of-the-hymenopteran-ovipositor
#13
Niclas R Fritzén, Ilari E Sääksjärvi
Apical serrations of the hymenopteran ovipositor have been widely postulated to originally constitute adaptations for cutting through hard substrates. Simplifications of the ovipositor tip have occurred in several ichneumonid wasp genera associated with spiders. Despite such reduction in Clistopyga (Hymenoptera, Ichneumonidae), the ovipositor still possesses some apical serrations. Through the first detailed study, we believe, on the behaviour of an ovipositing Clistopyga species, we show that it can alter its ovipositor for different purposes and that the primary function of the apical serrations is clinging to its spider host as the spider attempts to escape...
August 2016: Biology Letters
https://www.readbyqxmd.com/read/27395745/the-neotropical-species-of-atractodes-hymenoptera-ichneumonidae-%C3%A2-cryptinae-i-the-a-propodeator-and-a-altoandinus-species-groups
#14
Santiago Bordera, Marina Mazón, Ilari E Sääksjärvi
The Neotropical species of the cryptine genus Atractodes are studied, and four species-groups are proposed. In this paper, A. altoandinus and A. propodeator species-groups are diagnosed. The former species-group occurs from southern Mexico to Brazil and includes some of the largest Atractodes species ever found, all possessing a strongly sloped propodeum; the latter species-group is only known from the Chilean Andes and includes one of the smallest species of Atractodes, characterised by a very short and curved tergite I and short first flagellomere...
July 8, 2016: Zootaxa
https://www.readbyqxmd.com/read/27394891/alexey-reshchikov-ilari-eerikki-s%C3%A3-%C3%A3-ksj%C3%A3-rvi-2015-seven-new-species-of-the-genus-physotarsus-townes-1966-hymenoptera-ichneumonidae-from-south-america-zootaxa-3972-1-026-042
#15
https://www.readbyqxmd.com/read/27297669/germline-mutations-of-brca1-gene-exon-11-are-not-associated-with-platinum-response-neither-with-survival-advantage-in-patients-with-primary-ovarian-cancer-understanding-the-clinical-importance-of-one-of-the-biggest-human-exons-a-study-of-the-tumor-bank-ovarian
#16
Desislava Dimitrova, Ilary Ruscito, Sven Olek, Rolf Richter, Alexander Hellwag, Ivana Türbachova, Hannah Woopen, Udo Baron, Elena Ioana Braicu, Jalid Sehouli
Germline mutations in BRCA1 gene have been reported in up to 20 % of epithelial ovarian cancer (EOC) patients. Distinct clinical characteristics have been attributed to this special EOC population. We hypothesized that mutations in different BRCA1 gene exons may differently affect the clinical course of the disease. The aim of this study was to analyze, in a large cohort of primary EOCs, the clinical impact of mutations in BRCA1 gene exon 11, the largest exon of the gene sequence encoding the 60 % of BRCA1 protein...
September 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27248977/lower-birth-rate-in-patients-with-total-hip-replacement
#17
MULTICENTER STUDY
Miia Artama, Eerik T Skyttä, Heini Huhtala, Mikko Leino, Ilari Kuitunen, Antti Eskelinen
Background and purpose - There have been few studies on the effect of THR on pregnancy or delivery, and they have mainly been based on small and regional data. We evaluated the birth rate nationwide in patients of fertile age with THR. Patients and methods - This nationwide population-based cohort study was based on registry data on 5,863 Finnish THR patients who had undergone a THR between 1985 and 2006, and who were aged 15-45 years (females) or 15-50 years (males) at the time of THR. The matched reference cohort consisted of 17,575 sex- and age-matched individuals (3 for each patient) who were alive and resident in Finland at the time of the patient's THR...
October 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27227548/inhibition-of-spinal-oxidative-stress-by-bergamot-polyphenolic-fraction-attenuates-the-development-of-morphine-induced-tolerance-and-hyperalgesia-in-mice
#18
Filomena Lauro, Luigino Antonio Giancotti, Sara Ilari, Concetta Dagostino, Micaela Gliozzi, Chiara Morabito, Valentina Malafoglia, William Raffaeli, Maurizio Muraca, Bianca M Goffredo, Vincenzo Mollace, Carolina Muscoli
Citrus Bergamia Risso, commonly known as Bergamot, is a fruit whose Essential Oil and Bergamot Polyphenolic Fraction have numerous medicinal properties. It is also an excellent antioxidant and in this study, for the first time, its potential effect on morphine induced tolerance in mice has been investigated. Our studies revealed that development of antinociceptive tolerance to repeated doses of morphine in mice is consistently associated with increased formation of superoxide, malondialdehyde and tyrosine-nitrated proteins in the dorsal horn of the spinal cord such as the enzyme glutamine synthase...
2016: PloS One
https://www.readbyqxmd.com/read/27180807/differential-neuronal-vulnerability-identifies-igf-2-as-a-protective-factor-in-als
#19
Ilary Allodi, Laura Comley, Susanne Nichterwitz, Monica Nizzardo, Chiara Simone, Julio Aguila Benitez, Ming Cao, Stefania Corti, Eva Hedlund
The fatal disease amyotrophic lateral sclerosis (ALS) is characterized by the loss of somatic motor neurons leading to muscle wasting and paralysis. However, motor neurons in the oculomotor nucleus, controlling eye movement, are for unknown reasons spared. We found that insulin-like growth factor 2 (IGF-2) was maintained in oculomotor neurons in ALS and thus could play a role in oculomotor resistance in this disease. We also showed that IGF-1 receptor (IGF-1R), which mediates survival pathways upon IGF binding, was highly expressed in oculomotor neurons and on extraocular muscle endplate...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27172403/comparative-analysis-between-rq-pcr-and-digital-droplet-pcr-of-immunoglobulin-t-cell-receptor-gene-rearrangements-to-monitor-minimal-residual-disease-in-acute-lymphoblastic-leukaemia
#20
Irene Della Starza, Vittorio Nunes, Marzia Cavalli, Lucia Anna De Novi, Caterina Ilari, Valerio Apicella, Antonella Vitale, Anna Maria Testi, Ilaria Del Giudice, Sabina Chiaretti, Robin Foà, Anna Guarini
Real-time quantitative polymerase chain reaction (RQ-PCR) is a standardized tool for minimal residual disease (MRD) monitoring in acute lymphoblastic leukaemia (ALL). The applicability of this technology is limited by the need of a standard curve based on diagnostic DNA. The digital droplet PCR (ddPCR) technology has been recently applied to various medical fields, but its use in MRD monitoring is under investigation. In this study, we analysed 50 ALL cases by both methods in two phases: in the first, we established analytical parameters to investigate the applicability of this new technique; in the second, we analysed MRD levels in 141 follow-up (FU) samples to investigate the possible use of ddPCR for MRD monitoring in ALL patients...
August 2016: British Journal of Haematology
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