keyword
MENU ▼
Read by QxMD icon Read
search

ilaris

keyword
https://www.readbyqxmd.com/read/29157948/neurturin-is-a-pgc-1%C3%AE-1-controlled-myokine-that-promotes-motor-neuron-recruitment-and-neuromuscular-junction-formation
#1
Richard Mills, Hermes Taylor-Weiner, Jorge C Correia, Leandro Z Agudelo, Ilary Allodi, Christina Kolonelou, Vicente Martinez-Redondo, Duarte M S Ferreira, Susanne Nichterwitz, Laura H Comley, Vanessa Lundin, Eva Hedlund, Jorge L Ruas, Ana I Teixeira
OBJECTIVE: We examined whether skeletal muscle overexpression of PGC-1α1 or PGC-1α4 affected myokine secretion and neuromuscular junction (NMJ) formation. METHODS: A microfluidic device was used to model endocrine signaling and NMJ formation between primary mouse myoblast-derived myotubes and embryonic stem cell-derived motor neurons. Differences in hydrostatic pressure allowed for fluidic isolation of either cell type or unidirectional signaling in the fluid phase...
November 7, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29145976/not-only-p-glycoprotein-amplification-of-the-abcb1-containing-chromosome-region-7q21-confers-multidrug-resistance-upon-cancer-cells-by-coordinated-overexpression-of-an-assortment-of-resistance-related-proteins
#2
Ilaria Genovese, Andrea Ilari, Yehuda G Assaraf, Francesco Fazi, Gianni Colotti
The development of drug resistance continues to be a dominant hindrance toward curative cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and in particular of ABCB1 (P-glycoprotein or MDR1) is a well-known resistance mechanism for a plethora of cancer chemotherapeutics including for example taxenes, anthracyclines, Vinca alkaloids, and epipodopyllotoxins, demonstrated by a large array of published papers, both in tumor cell lines and in a variety of tumors, including various solid tumors and hematological malignancies...
May 2017: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/29126181/childhood-music-training-induces-change-in-micro-and-macroscopic-brain-structure-results-from-a-longitudinal-study
#3
Assal Habibi, Antonio Damasio, Beatriz Ilari, Ryan Veiga, Anand A Joshi, Richard M Leahy, Justin P Haldar, Divya Varadarajan, Chitresh Bhushan, Hanna Damasio
Several studies comparing adult musicians and nonmusicians have shown that music training is associated with structural brain differences. It is not been established, however, whether such differences result from pre-existing biological traits, lengthy musical training, or an interaction of the two factors, or if comparable changes can be found in children undergoing music training. As part of an ongoing longitudinal study, we investigated the effects of music training on the developmental trajectory of children's brain structure, over two years, beginning at age 6...
November 8, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/29112334/wtf-nano-one-pot-dewatering-and-water-free-topochemical-modification-of-nanocellulose-in-ionic-liquids-or-gamma-valerolactone
#4
Tiina Laaksonen, Jussi Kari Juhani Helminen, Laura Lemetti, Jesper Långbacka, Daniel Rico Del Cerro, Michael Hummel, Erkko Ilari Filpponen, Antti Rantamäki, Tia Kakko, Marianna Kemell, Susanne Wiedmer, Sami Heikkinen, Ilkka Kilpeläinen, Alistair William Thomas King
It is shown that ionic liquids can be used to dewater birch kraft pulp cellulose nanofibrillar (CNF) suspension and act as a medium for water-free topochemical modification of the nanocellulose. Acetylation, was applied as a model reaction to investigate the degree of modification and scope of effective ionic liquid structures. Little difference in reactivity was observed when water was removed, after introduction of ionic liquid or molecular co-solvent. However, the viscoelastic properties of CNF suspended in two ionic liquids showed that the more basic, but non-dissolving ionic liquid, allows for better solvation of the CNF...
November 7, 2017: ChemSusChem
https://www.readbyqxmd.com/read/29106455/virapipe-scalable-parallel-pipeline-for-viral-metagenome-analysis-from-next-generation-sequencing-reads
#5
Altti Ilari Maarala, Zurab Bzhalava, Joakim Dillner, Keijo Heljanko, Davit Bzhalava
Motivation: Next Generation Sequencing (NGS) technology enables identification of microbial genomes from massive amount of human microbiomes more rapidly and cheaper than ever before. However, the traditional sequential genome analysis algorithms, tools, and platforms are inefficient for performing large-scale metagenomic studies on ever-growing sample data volumes. Currently, there is an urgent need for scalable analysis pipelines that enable harnessing all the power of parallel computation in computing clusters and in cloud computing environments...
November 2, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29093603/pi3k-akt-mtor-pathway-in-ovarian-cancer-treatment-are-we-on-the-right-track
#6
Maria Luisa Gasparri, Erlisa Bardhi, Ilary Ruscito, Andrea Papadia, Ammad Ahmad Farooqi, Claudia Marchetti, Giorgio Bogani, Irene Ceccacci, Michael D Mueller, Pierluigi Benedetti Panici
The high recurrence rate and the low overall survival in ovarian cancer suggest that a more specific therapeutic approach in addition to conventional treatment is required. Translational and clinical research is investigating new molecular targets in order to find an alternative way to affect tumor growth and to minimize the overlap of toxicity of antiblastic agents. Given its implication in many cellular activities including regulation of cell growth, motility, survival, proliferation, protein synthesis, autophagy, transcription, as well as angiogenesis, PI3K/AKT/mTOR is one of the most investigated intracellular signaling pathways...
October 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29075474/pellets-of-proof-first-glimpse-of-the-dietary-composition-of-adult-odonates-as-revealed-by-metabarcoding-of-feces
#7
Kari M Kaunisto, Tomas Roslin, Ilari E Sääksjärvi, Eero J Vesterinen
Recent advances in molecular techniques allow us to resolve the diet of unstudied taxa. Odonates are potentially important top-down regulators of many insects. Yet, to date, our knowledge of odonate prey use is based mainly on limited observations of odonates catching or eating their prey. In this study, we examine the potential use of metabarcoding in establishing the diet of three adult odonate species (Lestes sponsa, Enallagma cyathigerum, and Sympetrum danae) at a site in southwestern Finland. To this purpose, we compared three different methods for extracting DNA from fecal samples: the Macherey-Nagel Nucleospin XS kit, a traditional salt extraction, and the Zymo Research Fecal Microprep kit...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28993771/tumor-derived-microvesicles-modulate-antigen-cross-processing-via-reactive-oxygen-species-mediated-alkalinization-of-phagosomal-compartment-in-dendritic-cells
#8
Federico Battisti, Chiara Napoletano, Hassan Rahimi Koshkaki, Francesca Belleudi, Ilaria Grazia Zizzari, Ilary Ruscito, Sara Palchetti, Filippo Bellati, Pierluigi Benedetti Panici, Maria Rosaria Torrisi, Giulio Caracciolo, Fabio Altieri, Marianna Nuti, Aurelia Rughetti
Dendritic cells (DCs) are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8(+) T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity. Albeit intensively investigated, the in vivo mechanisms underlying efficient antigen cross-processing and presentation are not fully understood. Several pieces of evidence indicate that antigen transfer to DCs mediated by microvesicles (MVs) enhances antigen immunogenicity...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28930584/metal-and-metalloid-containing-drugs-for-the-treatment-of-trypanosomatid-diseases
#9
Gianni Colotti, Annarita Fiorillo, Andrea Ilari
The trypanosomatid-induced diseases are considered as neglected, because the countries where they kill people are not important markets for western big pharmaceutical companies. However, recently some effort has been made to translate the use of already known drugs to neglected infectious disease. Although many metals are essential to life, many disorders affecting metal homeostasis and bioavailability are responsible for several human diseases. Metals can be toxic even at very low concentrations and semimetals are classified as toxic and dangerous for the environment...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28924243/refined-karyotype-based-prognostic-stratification-of-chronic-lymphocytic-leukemia-with-a-low-and-very-low-risk-genetic-profile
#10
I Del Giudice, G M Rigolin, S Raponi, L Cafforio, C Ilari, J Wang, M Bordyuh, A Piciocchi, M Marinelli, M Nanni, S Tavolaro, M Filetti, A Bardi, E Tammiso, E Volta, M Negrini, E Saccenti, F R Mauro, D Rossi, G Gaidano, A Guarini, R Rabadan, A Cuneo, R Foà
No abstract text is available yet for this article.
September 19, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28757235/adult-onset-still-s-disease-the-evidence-that-anti-interleukin-1-treatment-is-effective-and-well-tolerated-a-comprehensive-literature-review
#11
REVIEW
Guido Junge, June Mason, Eugen Feist
The literature contains many reports of the use of commercially available anti-IL-1 agents (anakinra/Kineret(®), canakinumab/Ilaris(®), or rilonacept/Arcalyst(®)) in treatment-resistant adult-onset Still's disease (AOSD). These have been widely summarized in many review articles, but a full account of all reports with each of the agents used is not available. This literature review includes all reports of treatment outcomes in patients treated for AOSD with any commercially available anti-IL-1 agent (excluding cases of unconfirmed or atypical AOSD or treatments only for rare AOSD complications)...
June 23, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28726784/binding-of-doxorubicin-to-sorcin-impairs-cell-death-and-increases-drug-resistance-in-cancer-cells
#12
Ilaria Genovese, Annarita Fiorillo, Andrea Ilari, Silvia Masciarelli, Francesco Fazi, Gianni Colotti
Sorcin is a calcium binding protein that plays an important role in multidrug resistance (MDR) in tumors, since its expression confers resistance to doxorubicin and to other chemotherapeutic drugs. In this study, we show that Sorcin is able to bind doxorubicin, vincristine, paclitaxel and cisplatin directly and with high affinity. The high affinity binding of doxorubicin to sorcin has been demonstrated with different techniques, that is, surface plasmon resonance, fluorescence titration and X-ray diffraction...
July 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28720110/molecular-characterisation-of-protist-parasites-in-human-habituated-mountain-gorillas-gorilla-beringei-beringei-humans-and-livestock-from-bwindi-impenetrable-national-park-uganda
#13
Matthew J Nolan, Melisa Unger, Yuen-Ting Yeap, Emma Rogers, Ilary Millet, Kimberley Harman, Mark Fox, Gladys Kalema-Zikusoka, Damer P Blake
BACKGROUND: Over 60 % of human emerging infectious diseases are zoonotic, and there is growing evidence of the zooanthroponotic transmission of diseases from humans to livestock and wildlife species, with major implications for public health, economics, and conservation. Zooanthroponoses are of relevance to critically endangered species; amongst these is the mountain gorilla (Gorilla beringei beringei) of Uganda. Here, we assess the occurrence of Cryptosporidium, Cyclospora, Giardia, and Entamoeba infecting mountain gorillas in the Bwindi Impenetrable National Park (BINP), Uganda, using molecular methods...
July 18, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28691938/genetic-versus-epigenetic-brca1-silencing-pathways-clinical-effects-in-primary-ovarian-cancer-patients-a-study-of-the-tumor-bank-ovarian-cancer-consortium
#14
Tingting Sun, Ilary Ruscito, Desislava Dimitrova, Radoslav Chekerov, Hagen Kulbe, Udo Baron, Véronique Blanchard, Pierluigi Benedetti Panici, Silvia Darb-Esfahani, Jalid Sehouli, Sven Olek, Elena Ioana Braicu
OBJECTIVES: The aim of the present study was to assess in a large cohort of primary epithelial ovarian cancer patients the incidence and the clinical effect of BRCA1 genetic and epigenetic silencing mechanisms. METHODS: A total of 188 primary epithelial ovarian cancer patients, treated between 2000 and 2011 at the Charité University Hospital of Berlin, were included. The patients' tumor and blood samples were obtained from the Tumor Bank Ovarian Cancer Network (www...
July 6, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28640177/the-efficacy-of-fibrin-sealant-patches-in-reducing-the-incidence-of-lymphatic-morbidity-after-radical-lymphadenectomy-a-meta-analysis
#15
Maria Luisa Gasparri, Ilary Ruscito, Daniele Bolla, Pierluigi Benedetti Panici, Michael D Mueller, Andrea Papadia
BACKGROUND: Although pivotal in the oncological management of most tumors, radical lymphadenectomy is associated with a significant number of lymphatic complications. The aim of this meta-analysis is to evaluate the efficacy of fibrinogen sealant patches in reducing lymphadenectomy-related postoperative complications. METHODS/MATERIALS: The electronic databases PubMed, Medline, and Scopus were searched using the terms "lymphadenectomy" or "lymph node dissection" and "TachoSil," "TachoComb," or "fibrin sealant patch...
July 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28636417/a-novel-antimicrobial-approach-based-on-the-inhibition-of-zinc-uptake-in-salmonella-enterica
#16
REVIEW
Andrea Battistoni, Serena Ammendola, Emilia Chiancone, Andrea Ilari
In this review we discuss evidences suggesting that bacterial zinc homeostasis represents a promising target for new antimicrobial strategies. The ability of the gut pathogen Salmonella enterica sv Typhimurium to withstand the host responses aimed at controlling growth of the pathogen critically depends on the zinc importer ZnuABC. Strains lacking a functional ZnuABC or its soluble component ZnuA display a dramatic loss of pathogenicity, due to a reduced ability to express virulence factors; withstand the inflammatory response; and compete with other gut microbes...
June 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28571958/a-decade-of-a-quick-diagnosis-unit
#17
Joaquim Torné Cachot, José Manuel Baucells Azcona, Helena Camell Ilari
No abstract text is available yet for this article.
May 29, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28530806/photoluminescent-hybrids-of-cellulose-nanocrystals-and-carbon-quantum-dots-as-cytocompatible-probes-for-in-vitro-bioimaging
#18
Jiaqi Guo, Dongfei Liu, Ilari Filpponen, Leena-Sisko Johansson, Jani-Markus Malho, Sakeena Quraishi, Falk Liebner, Hélder A Santos, Orlando J Rojas
We present an approach to construct biocompatible and photoluminescent hybrid materials comprised of carbon quantum dots (CQDs) and TEMPO-oxidized cellulose nanocrystals (TO-CNCs). First, the amino-functionalized carbon quantum dots (NH2-CQDs) were synthesized using a simple microwave method, and the TO-CNCs were prepared by hydrochloric acid (HCl) hydrolysis followed by TEMPO-mediated oxidation. The conjugation of NH2-CQDs and TO-CNCs was conducted via carbodiimide-assisted coupling chemistry. The synthesized TO-CNC@CQD hybrid nanomaterials were characterized using X-ray photoelectron spectroscopy, cryo-transmittance electron microscopy, confocal microscopy, and fluorescence spectroscopy...
June 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28525846/exploring-the-clonal-evolution-of-cd133-aldehyde-dehydrogenase-1-aldh1-positive-cancer-stem-like-cells-from-primary-to-recurrent-high-grade-serous-ovarian-cancer-hgsoc-a-study-of-the-ovarian-cancer-therapy-innovative-models-prolong-survival-octips-consortium
#19
MULTICENTER STUDY
Ilary Ruscito, Dan Cacsire Castillo-Tong, Ignace Vergote, Iulia Ignat, Mandy Stanske, Adriaan Vanderstichele, Ram N Ganapathi, Jacek Glajzer, Hagen Kulbe, Fabian Trillsch, Alexander Mustea, Caroline Kreuzinger, Pierluigi Benedetti Panici, Charlie Gourley, Hani Gabra, Mirjana Kessler, Jalid Sehouli, Silvia Darb-Esfahani, Elena Ioana Braicu
BACKGROUND: High-grade serous ovarian cancer (HGSOC) causes 80% of all ovarian cancer (OC) deaths. In this setting, the role of cancer stem-like cells (CSCs) is still unclear. In particular, the evolution of CSC biomarkers from primary (pOC) to recurrent (rOC) HGSOCs is unknown. Aim of this study was to investigate changes in CD133 and aldehyde dehydrogenase-1 (ALDH1) CSC biomarker expression in pOC and rOC HGSOCs. METHODS: Two-hundred and twenty-four pOC and rOC intrapatient paired tissue samples derived from 112 HGSOC patients were evaluated for CD133 and ALDH1 expression using immunohistochemistry (IHC); pOCs and rOCs were compared for CD133 and/or ALDH1 levels...
July 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28487561/crowdsourcing-based-nationwide-tick-collection-reveals-the-distribution-of-ixodes-ricinus-and-i-persulcatus-and-associated-pathogens-in-finland
#20
Maija Laaksonen, Eeva Sajanti, Jani J Sormunen, Ritva Penttinen, Jari Hänninen, Kai Ruohomäki, Ilari Sääksjärvi, Eero J Vesterinen, Ilppo Vuorinen, Jukka Hytönen, Tero Klemola
A national crowdsourcing-based tick collection campaign was organized in 2015 with the objective of producing novel data on tick distribution and tick-borne pathogens in Finland. Nearly 20 000 Ixodes ticks were collected. The collected material revealed the nationwide distribution of I. persulcatus for the first time and a shift northwards in the distribution of I. ricinus in Finland. A subset of 2038 tick samples containing both species was screened for Borrelia burgdorferi sensu lato (the prevalence was 14...
May 10, 2017: Emerging Microbes & Infections
keyword
keyword
107138
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"