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https://www.readbyqxmd.com/read/29758517/identification-of-chalcone-based-antileishmanial-agents-targeting-trypanothione-reductase
#1
Margherita Ortalli, Andrea Ilari, Gianni Colotti, Ilenia De Ionna, Theo Battista, Alessandra Bisi, Silvia Gobbi, Angela Rampa, Rita M C Di Martino, Giovanna A Gentilomi, Stefania Varani, Federica Belluti
All currently used first-line and second-line drugs for the treatment of leishmaniasis exhibit several drawbacks including toxicity, high costs and route of administration. Furthermore, some drugs are associated with the emergence of drug resistance. Thus, the development of new treatments for leishmaniasis is a priority in the field of neglected tropical diseases. The present work highlights the use of natural derived products, i.e. chalcones, as potential source of antileishmanial agents. Thirty-one novel chalcone compounds have been synthesized and their activity has been evaluated against promastigotes of Leishmania donovani; 16 compounds resulted active against L...
May 2, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29753392/the-prognostic-impact-of-cancer-stem-like-cell-biomarker-aldehyde-dehydrogenase-1-aldh1-in-ovarian-cancer-a-meta-analysis
#2
Ilary Ruscito, Silvia Darb-Esfahani, Hagen Kulbe, Filippo Bellati, Ilaria Grazia Zizzari, Hassan Rahimi Koshkaki, Chiara Napoletano, Donatella Caserta, Aurelia Rughetti, Mirjana Kessler, Jalid Sehouli, Marianna Nuti, Elena Ioana Braicu
OBJECTIVE: To investigate the association of cancer stem cell biomarker aldehyde dehydrogenase-1 (ALDH1) with ovarian cancer patients' prognosis and clinico-pathological characteristics. METHODS: The electronic searches were performed in January 2018 through the databases PubMed, MEDLINE and Scopus by searching the terms: "ovarian cancer" AND "immunohistochemistry" AND ["aldehyde dehydrogenase-1" OR "ALDH1" OR "cancer stem cell"]...
May 10, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29748134/oxysterol-binding-protein-related-proteins-orps-5-and-8-regulate-calcium-signaling-at-specific-cell-compartments
#3
Ilari Pulli, Taru Lassila, Guoping Pan, Daoguang Yan, Vesa M Olkkonen, Kid Törnquist
Oxysterol-binding protein related-protein 5 and 8 (ORP5/8) localize to the membrane contact sites (MCS) of the endoplasmic reticulum (ER) and the mitochondria, as well as to the ER-plasma membrane (PM) MCS. The MCS are emerging as important regulators of cell signaling events, including calcium (Ca2+ ) signaling. ORP5/8 have been shown to interact with phosphatidylinositol-4,5-bisphosphate (PIP2 ) in the PM, and to modulate mitochondrial respiration and morphology. PIP2 is the direct precursor of inositol trisphosphate (IP3 ), a key second messenger responsible for Ca2+ -release from the intracellular Ca2+ stores...
March 13, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29744295/anticancer-activity-of-the-protein-kinase-c-modulator-hmi-1a3-in-2d-and-3d-cell-culture-models-of-androgen-responsive-and-androgen-unresponsive-prostate-cancer
#4
Maria H Jäntti, Virpi Talman, Kati Räsänen, Ilari Tarvainen, Hannu Koistinen, Raimo K Tuominen
Prostate cancer is one of the most common cancers in men. Although it has a relatively high 5-year survival rate, development of resistance to standard androgen-deprivation therapy is a significant clinical problem. Therefore, novel therapeutic strategies are urgently needed. The protein kinase C (PKC) family is a putative prostate cancer drug target, but so far no PKC-targeting drugs are available for clinical use. By contrast to the standard approach of developing PKC inhibitors, we have developed isophthalate derivatives as PKC agonists...
May 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29726680/natural-stilbenoids-have-anti-inflammatory-properties-in-vivo-and-down-regulate-the-production-of-inflammatory-mediators-no-il6-and-mcp1-possibly-in-a-pi3k-akt-dependent-manner
#5
Heikki Eräsalo, Mari Hämäläinen, Tiina Leppänen, Ilari Mäki-Opas, Mirka Laavola, Raisa Haavikko, Jari Yli-Kauhaluoma, Eeva Moilanen
Stilbenoids are a group of polyphenolic compounds found in plants, trees, berries, and nuts. Stilbenoids have been shown to serve an antimicrobial and antifungal function in plants. There is also evidence that as a part of the human diet, stilbenoids play an important role as antioxidants and may have anti-inflammatory effects. The PI3K/Akt pathway is a well-characterized signaling pathway controlling cellular functions involved in growth and cell cycle and in metabolism. There is also increasing evidence to show the involvement of this pathway in the regulation of inflammatory responses...
May 4, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29704533/sphingolipid-mediated-calcium-signaling-and-its-pathological-effects
#6
Ilari Pulli, Muhammad Yasir Asghar, Kati Kemppainen, Kid Törnquist
Metabolites of sphingomyelin, as well as calcium ion fluxes, have a profound role in cellular signaling in almost all cell types. In addition, metabolites of sphingomyelin often modulate calcium signaling, either directly or indirectly. This is an interesting aspect on how lipids may wield their physiological role, as calcium is probably one of the most versatile signaling molecules in the cell, and as modulation of calcium signaling has profound effects on cellular physiology. The aim of this review is to discuss the mechanisms by which metabolites of sphingomyelin, especially the sphingolipids sphingosine and sphingosine 1-phosphate (S1P), modulate calcium fluxes, and how this may affect cellular function...
April 25, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29700053/tk-inhibitor-pazopanib-primes-dcs-by-downregulation-of-the-%C3%AE-catenin-pathway
#7
Ilaria Grazia Zizzari, Chiara Napoletano, Andrea Botticelli, Salvatore Caponnetto, Fabio Calabrò, Alain Gelibter, Aurelia Rughetti, Ilary Ruscito, Hassan Rahimi, Ernesto Rossi, Giovanni Schinzari, Paolo Marchetti, Marianna Nuti
Tyrosine kinase inhibitors (TKIs) target angiogenesis by affecting, for example, the VEGF receptors in tumors and have improved outcomes for patients with metastatic renal cell carcinoma (mRCC). Immune checkpoint inhibitors (ICIs) have also been proposed for treatment of mRCC with encouraging results. A better understanding of the activity of immune cells in mRCC, the immuneomodulatory effects of TKIs, and the characteristics defining patients most likely to benefit from various therapies will help optimize immunotherapeutic approaches...
April 26, 2018: Cancer Immunology Research
https://www.readbyqxmd.com/read/29687006/immunobiology-of-solid-cancers-cellular-and-molecular-pathways-as-potential-diagnostic-and-therapeutic-targets
#8
EDITORIAL
Ilary Ruscito, Elena Ioana Braicu, Maria Luisa Gasparri, Ilaria Grazia Zizzari
No abstract text is available yet for this article.
2018: BioMed Research International
https://www.readbyqxmd.com/read/29674292/the-influence-of-mineral-particles-on-fibroblast-behaviour-a-comparative-study
#9
Diosangeles Soto Veliz, Jens C Luoto, Ilari Pulli, Martti Toivakka
Minerals are versatile tools utilised to modify and control the physical-chemical and functional properties of substrates. Those properties include ones directing cell fate; thus, minerals can potentially provide a direct and inexpensive method to manipulate cell behaviour. This paper shows how different minerals influence human dermal fibroblast behaviour depending on their properties. Different calcium carbonates, calcium sulphates, silica, silicates, and titanium dioxide were characterised using TEM, ATR-FTIR, and zeta potential measurements...
April 10, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29643459/1-5-%C3%A2-c-carbon-budget-dependent-on-carbon-cycle-uncertainty-and-future-non-co-2-forcing
#10
Nadine Mengis, Antti-Ilari Partanen, Jonathan Jalbert, H Damon Matthews
Estimates of the 1.5 °C carbon budget vary widely among recent studies, emphasizing the need to better understand and quantify key sources of uncertainty. Here we quantify the impact of carbon cycle uncertainty and non-CO2 forcing on the 1.5 °C carbon budget in the context of a prescribed 1.5 °C temperature stabilization scenario. We use Bayes theorem to weight members of a perturbed parameter ensemble with varying land and ocean carbon uptake, to derive an estimate for the fossil fuel (FF) carbon budget of 469 PgC since 1850, with a 95% likelihood range of (411,528) PgC...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29611195/in-chronic-lymphocytic-leukaemia-with-complex-karyotype-major-structural-abnormalities-identify-a-subset-of-patients-with-inferior-outcome-and-distinct-biological-characteristics
#11
Gian Matteo Rigolin, Elena Saccenti, Emanuele Guardalben, Maurizio Cavallari, Luca Formigaro, Barbara Zagatti, Andrea Visentin, Francesca R Mauro, Enrico Lista, Cristian Bassi, Laura Lupini, Francesca Maria Quaglia, Antonio Urso, Maria Antonella Bardi, Laura Bonaldi, Eleonora Volta, Elisa Tammiso, Caterina Ilari, Luciana Cafforio, Aurora Melandri, Francesco Cavazzini, Massimo Negrini, Gianpietro Semenzato, Livio Trentin, Robin Foà, Antonio Cuneo
Complex karyotype (CK) is a negative prognostic factor in chronic lymphocytic leukaemia (CLL). However, CK is a heterogeneous cytogenetic category. Unbalanced rearrangements were present in 73·3% of 90 CLL patients with CK (i.e. ≥3 chromosome aberrations in the same clone), and were associated with a shorter overall survival (P = 0·025) and a shorter time to first treatment (P = 0·043) by multivariate analysis. Patients with unbalanced rearrangements presented a distinct mRNA expression profile. In conclusion, CLL patients with unbalanced rearrangements might represent a subset of very high-risk CLL patients with distinct clinical and biological characteristics...
April 2, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29508399/music-training-and-child-development-a-review-of-recent-findings-from-a-longitudinal-study
#12
REVIEW
Assal Habibi, Antonio Damasio, Beatriz Ilari, Matthew Elliott Sachs, Hanna Damasio
Evidence suggests that learning to play music enhances musical processing skills and benefits other cognitive abilities. Furthermore, studies of children and adults indicate that the brains of musicians and nonmusicians are different. It has not been determined, however, whether such differences result from pre-existing traits, musical training, or an interaction between the two. As part of an ongoing longitudinal study, we investigated the effects of music training on children's brain and cognitive development...
March 6, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29486399/generation-of-induced-pluripotent-stem-cell-line-cssi004-a-2962-from-a-patient-diagnosed-with-huntington-s-disease-at-the-presymptomatic-stage
#13
Eris Bidollari, Giovannina Rotundo, Daniela Ferrari, Ornella Candido, Laura Bernardini, Federica Consoli, Alessandro De Luca, Iolanda Santimone, Giuseppe Lamorte, Andrea Ilari, Ferdinando Squitieri, Angelo Luigi Vescovi, Jessica Rosati
Huntington's disease (HD) is an incurable, autosomal dominant, hereditary neurodegenerative disorder that typically manifests itself in midlife. This pathology is linked to the deregulation of multiple, as yet unknown, cellular processes starting before HD onset. A human iPS cell line was generated from skin fibroblasts of a subject at the presymptomatic life stage, carrying a polyglutamine expansion in HTT gene codifying Huntingtin protein. The iPSC line contained the expected CAG expansion, expressed the expected pluripotency markers, displayed in vivo differentiation potential to the three germ layers and had a normal karyotype...
April 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29466768/dynamics-of-the-intratumoral-immune-response-during-progression-of-high-grade-serous-ovarian-cancer
#14
Mandy Stanske, Stephan Wienert, Dan Cacsire Castillo-Tong, Caroline Kreuzinger, Ignace Vergote, Sandrijne Lambrechts, Hani Gabra, Charlie Gourley, Ram N Ganapathi, Ivonne Kolaschinski, Jan Budczies, Jalid Sehouli, Ilary Ruscito, Carsten Denkert, Hagen Kulbe, Wolfgang Schmitt, Korinna Jöhrens, Ioana Braicu, Silvia Darb-Esfahani
PURPOSE: Tumor-infiltrating lymphocytes (TILs) have an established impact on the prognosis of high-grade serous ovarian carcinoma (HGSOC), however, their role in recurrent ovarian cancer is largely unknown. We therefore systematically investigated TIL densities and MHC class I and II (MHC1, 2) expression in the progression of HGSOC. EXPERIMENTAL DESIGN: CD3+, CD4+, CD8+ TILs and MHC1, 2 expression were evaluated by immunohistochemistry on tissue microarrays in 113 paired primary and recurrent HGSOC...
March 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29455750/trigger-events-and-poverty-transitions-among-young-adults-in-finland-after-leaving-the-parental-home
#15
Ilari Ilmakunnas
Studies have shown that leaving the parental home is associated with an increase in the risk of poverty. However, less is known about poverty dynamics after leaving the nest. Based on Finnish population register data, this research answers the question of how employment and demographic events affect poverty entries and exits among 18- to 24-year-olds in Finland. The follow-up of individuals starts when young adults move away from the parental home. In addition to descriptive methods, discrete-time event-history models are estimated...
February 2018: Social Science Research
https://www.readbyqxmd.com/read/29454149/study-of-manganese-binding-to-the-ferroxidase-centre-of-human-h-type-ferritin
#16
Matteo Ardini, Barry D Howes, Annarita Fiorillo, Elisabetta Falvo, Silvia Sottini, Donella Rovai, Marco Lantieri, Andrea Ilari, Dante Gatteschi, Gabriele Spina, Emilia Chiancone, Simonetta Stefanini, Maria Fittipaldi
Ferritins are ubiquitous and conserved proteins endowed with enzymatic ferroxidase activity, that oxidize Fe(II) ions at the dimetal ferroxidase centre to form a mineralized Fe(III) oxide core deposited within the apo-protein shell. Herein, the in vitro formation of a heterodimetal cofactor constituted by Fe and Mn ions has been investigated in human H ferritin (hHFt). Namely, Mn and Fe binding at the hHFt ferroxidase centre and its effects on Fe(II) oxidation have been investigated by UV-Vis ferroxidation kinetics, fluorimetric titrations, multifrequency EPR, and preliminary Mössbauer spectroscopy...
May 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29407158/hydrazone-crosslinked-hyaluronan-based-hydrogels-for-therapeutic-delivery-of-adipose-stem-cells-to-treat-corneal-defects
#17
Laura Koivusalo, Jennika Karvinen, Eetu Sorsa, Ilari Jönkkäri, Jari Väliaho, Pasi Kallio, Tanja Ilmarinen, Susanna Miettinen, Heli Skottman, Minna Kellomäki
Corneal blindness is a worldwide problem, plagued by insufficient amount of high-quality donor tissue. Cell therapy using human adipose stem cells (hASCs) has risen as an alternative to regenerate damaged corneal stromal tissue, the main structural and refractive layer of the cornea. Herein we propose a method to deliver hASCs into corneal defects in hyaluronan (HA)-based hydrogels, which form rapidly in situ by hydrazone crosslinking. We fabricated two different HA-based hydrazone-crosslinked hydrogels (HALD1-HACDH and HALD2-HAADH), and characterized their swelling, degradation, mechanical, rheological and optical properties and their ability to support hASC survival...
April 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29365086/genetic-landscape-of-ultra-stable-chronic-lymphocytic-leukemia-patients
#18
S Raponi, I Del Giudice, M Marinelli, J Wang, L Cafforio, C Ilari, A Piciocchi, M Messina, S Bonina, S Tavolaro, M Bordyuh, P Mariglia, N Peragine, F R Mauro, S Chiaretti, S Molica, M Gentile, A Visentin, L Trentin, G M Rigolin, A Cuneo, F Diop, D Rossi, G Gaidano, A Guarini, R Rabadan, R Foà
Background: Chronic lymphocytic leukemia (CLL) has a heterogeneous clinical course. Beside patients requiring immediate treatment, others show an initial indolent phase followed by progression and others do not progress for decades. The latter two subgroups usually display mutated IGHV genes and a favorable FISH profile. Patients and Methods: Patients with absence of disease progression for over 10 years (11-30) from diagnosis were defined as ultra-stable CLL (US-CLL)...
January 22, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29258584/lymphocyte-opioid-receptors-as-innovative-biomarkers-of-osteoarthritic-pain-for-the-assessment-and-risk-management-of-opioid-tailored-therapy-before-hip-surgery-to-prevent-chronic-pain-and-opioid-tolerance-addiction-development-opmarkart-opioids-markers-arthroprosthesis
#19
Valentina Malafoglia, Monica Celi, Carolina Muscoli, Sara Ilari, Filomena Lauro, Luigino Antonio Giancotti, Chiara Morabito, Maurizio Feola, Umberto Tarantino, William Raffaeli
BACKGROUND: The incidence of post-surgical chronic pain ranges between 20% and 40% in Europe. Osteoarthritis pain after prosthesis implantation is one of the most severe secondary syndromes, depending not only on surgery but also on organic changes before and after joints replacement. No data are available about risk factors. An excessive inflammatory response plays a central role but a best therapy is not defined yet. It is not clear whether opioid administration could influence post-surgical pain and lead to tolerance or addiction...
December 19, 2017: Trials
https://www.readbyqxmd.com/read/29242506/micrornas-regulate-key-cell-survival-pathways-and-mediate-chemosensitivity-during-progression-of-diffuse-large-b-cell-lymphoma
#20
Suvi-Katri Leivonen, Katherine Icay, Kirsi Jäntti, Ilari Siren, Chengyu Liu, Amjad Alkodsi, Alejandra Cervera, Maja Ludvigsen, Stephen Jacques Hamilton-Dutoit, Francesco d'Amore, Marja-Liisa Karjalainen-Lindsberg, Jan Delabie, Harald Holte, Rainer Lehtonen, Sampsa Hautaniemi, Sirpa Leppä
Despite better therapeutic options and improved survival of diffuse large B-cell lymphoma (DLBCL), 30-40% of the patients experience relapse or have primary refractory disease with a dismal prognosis. To identify biological correlates for treatment resistance, we profiled microRNAs (miRNAs) of matched primary and relapsed DLBCL by next-generation sequencing. Altogether 492 miRNAs were expressed in the DLBCL samples. Thirteen miRNAs showed significant differential expression between primary and relapse specimen pairs...
December 15, 2017: Blood Cancer Journal
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