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https://www.readbyqxmd.com/read/28338977/effects-of-augmenting-n-methyl-d-aspartate-receptor-signaling-on-working-memory-and-experience-dependent-plasticity-in-schizophrenia-an-exploratory-study-using-acute-d-cycloserine
#1
Jennifer K Forsyth, Peter Bachman, Daniel H Mathalon, Brian J Roach, Elissa Ye, Robert F Asarnow
Cognitive deficits in schizophrenia have been hypothesized to reflect N-methyl-D-aspartate receptor (NMDAR) dysfunction. However, the mechanisms through which the NMDAR contributes to individual cognitive functions differ. To explore how NMDAR signaling relates to specific cognitive deficits in schizophrenia, we tested the effects of enhancing NMDAR signaling on working memory and experience-dependent plasticity using d-cycloserine (DCS). Plasticity was assessed using an EEG paradigm that utilizes high-frequency visual stimulation (HFvS) to induce neural potentiation, and 2 learning tasks, the information integration (IIT) and weather prediction (WPT) tasks...
March 17, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28336762/automated-detection-of-look-alike-sound-alike-medication-errors
#2
Christine Rash-Foanio, William Galanter, Michelle Bryson, Suzanne Falck, King Lup Liu, Gordon D Schiff, Allen Vaida, Bruce L Lambert
PURPOSE: The development and evaluation of an algorithm for detecting potential medication errors due to look-alike/sound-alike (LASA) drug names are described. SUMMARY: A computer algorithm that detects potential LASA errors by analyzing medication orders and diagnostic claims data was developed. The algorithm flags a potential error when (1) a medication order is not justified by a diagnosis documented in the patient's record, (2) another medication whose orthographic similarity to the index drug exceeds a specified threshold exists, and (3) the latter drug has an indication that matches an active documented diagnosis...
April 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28320719/antibiotic-effects-on-methicillin-resistant-staphylococcus-aureus-cytoplasmic-peptidoglycan-intermediate-levels-evidence-for-potential-metabolite-level-regulatory-loops
#3
Harika Vemula, Navid J Ayon, Alloch Burton, William G Gutheil
Cytoplasmic peptidoglycan (PG) precursor levels were determined in methicillin resistant S. aureus (MRSA) after exposure to several cell wall targeting antibiotics. Three experiments were performed: 1) Exposure to 4x MIC levels (acute). 2) Exposure to sub-MIC levels (sub-acute). 3) A time course of the effect of vancomycin. In acute exposure experiments, fosfomycin increased UDP-GlcNAc, as expected, and resulted in substantially lower levels of total UDP-linked metabolite accumulation relative to other pathway inhibitors, indicating reduced entry into this pathway...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28299303/the-efficacy-of-augment-of-d-cycloserine-and-cognitive-behavioral-therapy-on-adolescent-with-one-type-of-anxiety-disorders-a-double-blind-randomized-controlled-trial
#4
Soroor Arman, Ali Soheilimehr, Mohammad Reza Maracy
BACKGROUND: This study was designed to investigating the effect of combining D-cycloserine (DCS) and cognitive-behavioral therapy (CBT) on adolescent with at least one type of anxiety disorders. MATERIALS AND METHODS: The present study was conducted as a double-blind randomized controlled trial on 36 adolescent with anxiety disorders. Patients were assessed in two groups. In addition to 4 sessions of weekly CBT in both groups; case group, received a 50-mg DCS capsules, control group, received Placebo daily for a month...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28282427/d-cycloserine-augmentation-of-behavior-therapy-for-anxiety-and-obsessive-compulsive-disorders-a-meta-analysis
#5
Paul-Christian Bürkner, Nadine Bittner, Heinz Holling, Ulrike Buhlmann
OBJECTIVE: The present meta-analysis investigates whether the antibiotic D-cycloserine (DCS), a partial agonist at the glutamatergic N-methyl-D-aspartate receptor, can augment the effect of behavior therapy in humans with anxiety and obsessive-compulsive disorders. METHOD: A keyword-based computer search was conducted using common electronic databases. Only studies investigating the effect of DCS in humans with anxiety and obsessive-compulsive disorders were included, resulting in 23 studies with a combined sample size of 1314 patients...
2017: PloS One
https://www.readbyqxmd.com/read/28275863/post-reexposure-administration-of-d-cycloserine-facilitates-reconsolidation-of-contextual-conditioned-fear-memory-in-rats
#6
Akiyoshi Saitoh, Kie Akagi, Jun-Ichiro Oka, Mitsuhiko Yamada
The effect of D-cycloserine, a N-methyl-D-aspartate receptor partial agonist, on the reconsolidation of conditioned fear memory is not precisely understood. In this study, we clarified the effects of D-cycloserine on the reconsolidation in rats, by performing contextual fear conditioning with a mild fear-conditioning procedure and with post-reexposure administration of the drug. The D-cycloserine (15 mg/kg subcutaneously)-treated rats showed a persistent and greater fear response during the test session compared with the control group...
March 8, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28272868/mechanism-based-inhibition-of-the-mycobacterium-tuberculosis-branched-chain-aminotransferase-by-d-and-l-cycloserine
#7
Tathyana Mar Amorim Franco, Lorenza Favrot, Olivia Vergnolle, John S Blanchard
The branched-chain aminotransferase is a pyridoxal 5'-phosphate (PLP)-dependent enzyme responsible for the final step in the biosynthesis of all three branched-chain amino acids, L-leucine, L-isoleucine and L-valine, in bacteria. We have investigated the mechanism of inactivation of the branched-chain aminotransferase from Mycobacterium tuberculosis (MtIlvE) by D- and L-cycloserine. D-cycloserine is currently used only in the treatment of multidrug-drug resistant tuberculosis. Our results show a time- and concentration-dependent inactivation of MtIlvE by both isomers, with L-cycloserine being a 40-fold better inhibitor of the enzyme...
March 8, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28269783/modulating-the-balance-of-synaptic-and-extrasynaptic-nmda-receptors-shows-positive-effects-against-amyloid-%C3%AE-induced-neurotoxicity
#8
Yan Huang, Wei Shen, Jie Su, Bin Cheng, Dong Li, Gang Liu, Wen-Xia Zhou, Yong-Xiang Zhang
Alzheimer's disease (AD) patients suffer a disturbance in the balance between synaptic (GluN2A, mediating the protective pathway) and extrasynaptic NMDA receptors (NMDARs) (GluN2B, mediating the excitotoxic pathway), and, therefore, restoring the balance of GluN2A and GluN2B should be beneficial for AD. In this study, the GluN2B-selective antagonist, ifenprodil, and the non-selective NMDAR agonist, NMDA, had little effect on amyloid-β (Aβ)-induced long-term potentiation deficits. Enhancing the activity of GluN2A had a protective effect against Aβ, and specific activation of GluN2A and inhibition of GluN2B showed a better protective effect...
March 2, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28251909/enhancing-cognitive-behavioral-therapy-is-the-finish-line-in-sight
#9
Vasiliki Michopoulos
Augmentation of cognitive behavioral therapy with D-cycloserine (DCS) for anxiety disorders results in a small decrease in symptom severity.
March 1, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28245819/effects-of-sarcosine-and-n-n-dimethylglycine-on-nmda-receptor-mediated-excitatory-field-potentials
#10
Mei-Yi Lee, Yi-Ruu Lin, Yi-Shu Tu, Yufeng Jane Tseng, Ming-Huan Chan, Hwei-Hsien Chen
BACKGROUND: Sarcosine, a glycine transporter type 1 inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site, potentiates NMDA receptor function. Structurally similar to sarcosine, N,N-dimethylglycine (DMG) is also N-methyl glycine-derivative amino acid and commonly used as a dietary supplement. The present study compared the effects of sarcosine and DMG on NMDA receptor-mediated excitatory field potentials (EFPs) in mouse medial prefrontal cortex brain slices using a multi-electrode array system...
February 28, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28244290/additional-drug-resistance-patterns-among-multidrug-resistant-tuberculosis-patients-in-korea-implications-for-regimen-design
#11
Jeong Ha Mok, Bo Hyoung Kang, Taehoon Lee, Hyun Kyung Lee, Hang Jea Jang, Yu Ji Cho, Doosoo Jeon
Detailed information on additional drug resistance patterns of multidrug-resistant tuberculosis (MDR-TB) is essential to build an effective treatment regimen; however, such data are scarce in Korea. We retrospectively analyzed the results of phenotypic drug susceptibility testing (DST) of culture confirmed-TB patients from January 2010 to December 2014 in 7 university hospitals in Korea. MDR-TB was identified among 6.8% (n = 378) of 5,599 isolates. A total of 57.1% (n = 216) of the MDR-TB patients had never been treated for TB...
April 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28231674/-a-preliminary-study-on-the-molecular-characteristics-of-d-cycloserine-resistance-of-mycobacterium-tuberculosis
#12
C Li, G L Li, Q Luo, S J Li, R B Wang, Y L Lou, J X Lyu, K L Wan
Objective: To investigate the relationship between D-cycloserine resistance and the gene mutations of alrA, ddlA and cycA of Mycobacterium (M.) tuberculosis, as well as the association between D-cycloserine resistance and spoligotyping genotyping. Methods: A total of 145 M. tuberculosis strains were selected from the strain bank. D-cycloserine resistant phenotypes of the strains were determined by the proportion method and the minimal inhibitory concentration was determined by resazurin microtiter assay. PCR amplification and DNA direct sequencing methods were used for the analysis of gene mutations...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28224247/a-simplified-lc-ms-ms-method-for-rapid-determination-of-cycloserine-in-small-volume-human-plasma-using-protein-precipitation-coupled-with-dilution-techniques-to-overcome-matrix-effects-and-its-application-to-a-pharmacokinetic-study
#13
Zhengsheng Mao, Xin Wang, Bingxin Li, Jing Jin, Ming Xu, Youping Liu, Xin Di
Matrix effects have been a major concern when developing LC-MS/MS methods for quantitative bioanalysis of cycloserine. Sample handling procedures including solid phase extraction or derivatization have been reported previously by researchers to overcome matrix effects of cycloserine. In the present study, the possibility of reducing matrix effects of cycloserine using protein precipitation coupled with dilution techniques was investigated. Plasma samples were pretreated by protein precipitation with methanol followed by a 40-fold dilution with methanol-water (50:50, v/v)...
April 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28197902/neuropsychiatric-effects-of-antimicrobial-agents
#14
REVIEW
Nicholas Zareifopoulos, George Panayiotakopoulos
Antimicrobial drugs used in clinical practice are selected on the basis of their selective toxicity against bacterial cells. However, all exhibit multiple offsite interactions with eukaryotic cell structures, resulting in adverse reactions during antimicrobial pharmacotherapy. A multitude of these side effects involve the nervous system as antimicrobials at clinically relevant concentrations seem to interact with many of the same molecules usually implicated in the action of psychotropic drugs. The importance of such events cannot be overstated, as the misdiagnosis of an adverse drug reaction as a symptom of a primary psychiatric or neurological disorder entails great suffering for the patient affected as well as significant costs for the healthcare system...
February 14, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28194724/ketamine-and-beyond-investigations-into-the-potential-of-glutamatergic-agents-to-treat-depression
#15
REVIEW
Marc S Lener, Bashkim Kadriu, Carlos A Zarate
Clinical and preclinical studies suggest that dysfunction of the glutamatergic system is implicated in mood disorders such as major depressive disorder and bipolar depression. In clinical studies of individuals with major depressive disorder and bipolar depression, rapid reductions in depressive symptoms have been observed in response to subanesthetic-dose ketamine, an agent whose mechanism of action involves the modulation of glutamatergic signaling. The findings from these studies have prompted the repurposing and/or development of other glutamatergic modulators for antidepressant efficacy, both as monotherapy or as an adjunct to conventional monoaminergic antidepressants...
March 2017: Drugs
https://www.readbyqxmd.com/read/28138381/d-cycloserine-enhances-durability-of-social-skills-training-in-autism-spectrum-disorder
#16
Logan K Wink, Noha F Minshawi, Rebecca C Shaffer, Martin H Plawecki, David J Posey, Paul S Horn, Ryan Adams, Ernest V Pedapati, Tori L Schaefer, Christopher J McDougle, Naomi B Swiezy, Craig A Erickson
BACKGROUND: d-Cycloserine (DCS) enhances extinction learning across species, but it has proven challenging to identify consistent benefit of DCS when added to therapeutic interventions. We conducted a placebo-controlled trial of DCS to potentiate social skills training in autism spectrum disorder (ASD) but found substantial improvement in both the DCS and placebo groups at the conclusion of active treatment. Here, we assess the impact of DCS 11 weeks following active treatment to evaluate the impact of DCS on treatment response durability...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28122091/d-cycloserine-augmentation-of-exposure-based-cognitive-behavior-therapy-for-anxiety-obsessive-compulsive-and-posttraumatic-stress-disorders-a-systematic-review-and-meta-analysis
#17
David Mataix-Cols, Lorena Fernández de la Cruz, Benedetta Monzani, David Rosenfield, Erik Andersson, Ana Pérez-Vigil, Paolo Frumento, Rianne A de Kleine, JoAnn Difede, Boadie W Dunlop, Lara J Farrell, Daniel Geller, Maryrose Gerardi, Adam J Guastella, Stefan G Hofmann, Gert-Jan Hendriks, Matt G Kushner, Francis S Lee, Eric J Lenze, Cheri A Levinson, Harry McConnell, Michael W Otto, Jens Plag, Mark H Pollack, Kerry J Ressler, Thomas L Rodebaugh, Barbara O Rothbaum, Michael S Scheeringa, Anja Siewert-Siegmund, Jasper A J Smits, Eric A Storch, Andreas Ströhle, Candyce D Tart, David F Tolin, Agnes van Minnen, Allison M Waters, Carl F Weems, Sabine Wilhelm, Katarzyna Wyka, Michael Davis, Christian Rück
Importance: Whether and under which conditions D-cycloserine (DCS) augments the effects of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders is unclear. Objective: To clarify whether DCS is superior to placebo in augmenting the effects of cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders and to evaluate whether antidepressants interact with DCS and the effect of potential moderating variables...
January 25, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28081169/assessment-of-a-96-well-plate-assay-of-quantitative-drug-susceptibility-testing-for-mycobacterium-tuberculosis-complex-in-china
#18
Hui Xia, Yang Zheng, Bing Zhao, Susan van den Hof, Frank Cobelens, YanLin Zhao
OBJECTIVE: To evaluate the performance of the Sensitire MYCOTB MIC Plate (MYCOTB) which could measure the twelve anti-tuberculosis drugs susceptibility on one 96-wells plate. METHODS: A total of 140 MDR-TB strains and 60 non-MDR strains were sub-cultured and 193 strains were finally tested for drug resistance using MYCOTB and agar proportion method (APM) and another 7 strains failed of subculture. The drugs included ofloxacin (Ofx), moxifloxacin (Mfx), rifampin (RFP), amikacin (Am), rifabutin (Rfb), para-aminosalicylic acid (PAS), ethionamide (Eth), isoniazid (INH), kanamycin (Km), ethambutol (EMB), streptomycin (Sm), and cycloserine(Cs)...
2017: PloS One
https://www.readbyqxmd.com/read/28042035/structural-and-functional-characterization-of-the-alanine-racemase-from-streptomyces-coelicolor-a3-2
#19
Raffaella Tassoni, Lizah T van der Aart, Marcellus Ubbink, Gilles P van Wezel, Navraj S Pannu
The conversion of l-alanine (L-Ala) into d-alanine (D-Ala) in bacteria is performed by pyridoxal phosphate-dependent enzymes called alanine racemases. D-Ala is an essential component of the bacterial peptidoglycan and hence required for survival. The Gram-positive bacterium Streptomyces coelicolor has at least one alanine racemase encoded by alr. Here, we describe an alr deletion mutant of S. coelicolor which depends on D-Ala for growth and shows increased sensitivity to the antibiotic d-cycloserine (DCS)...
January 29, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28018227/bidirectional-effects-of-cannabidiol-on-contextual-fear-memory-extinction
#20
Chenchen Song, Carl W Stevenson, Francisco S Guimaraes, Jonathan L C Lee
Cannabidiol (CBD) has been established to have both acute and long-lasting effects to reduce fear memory expression. The long-lasting impact might be mediated by an enhancement of memory extinction or an impairment of memory reconsolidation. Here, we directly compared the effects of i.p. injections of cannabidiol (10 mg/kg) with those of the NMDA receptor antagonist MK-801 (0.1 mg/kg) and partial agonist D-cycloserine (DCS; 15 mg/kg) in order to determine the mnemonic basis of long-term fear reduction. We showed that under conditions of strong fear conditioning, CBD reduced contextual fear memory expression both acutely during the extinction session as well as later at a fear retention test...
2016: Frontiers in Pharmacology
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