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Tongue Pathology

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https://www.readbyqxmd.com/read/28289481/role-of-mri-in-evaluation-of-malignant-lesions-of-tongue-and-oral-cavity
#1
Amandeep Singh, Chuni Lal Thukral, Kamlesh Gupta, Arvinder Singh Sood, Hanish Singla, Kunwarpal Singh
BACKGROUND: Aim of the present study was to evaluate the role of MRI in staging of malignant lesions of the oral cavity and to correlate MRI findings with clinical/surgical and anatomical-pathological findings, wherever possible. MATERIAL/METHODS: The study included 50 patients who presented with malignant lesions of the oral cavity and were referred to radiology departments for MRI. All patients included were subjected to a detailed physical examination following which MRI was carried out on Philips Gyroscan Achieva 1...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28278337/a-proposal-to-redefine-close-surgical-margins-in-squamous-cell-carcinoma-of-the-oral-tongue
#2
Daniella Karassawa Zanoni, Jocelyn C Migliacci, Bin Xu, Nora Katabi, Pablo H Montero, Ian Ganly, Jatin P Shah, Richard J Wong, Ronald A Ghossein, Snehal G Patel
Importance: Resection of the primary tumor with negative margins is the gold standard treatment for squamous cell carcinoma of the oral tongue (SCCOT). A microscopically positive surgical margin is clearly associated with a higher risk for local recurrence, whereas a negative margin has traditionally been defined as greater than 5.0 mm clearance from the tumor, with lesser margins arbitrarily designated as close. The precise cutoff at which the risk for local recurrence with a close margin approximates that of a microscopically positive margin remains unclear...
March 9, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28274072/versatility-of-tongue-flaps-for-closure-of-palatal-defects-case-report
#3
Vishnu Mohan, Roopesh U Nair, Arjun Madhu Usha
Palatal defects following congenital anomalies, traumatic injuries, benign and malignant pathologies frequently require resection and reconstruction. Reconstruction of these defects is challenging and complex due to the amount of tissue left for primary closure after excision, compromised vasculature as on repaired cleft palate and limited pedicled flaps around the lesion. Tongue flap though doesn't fulfil all the ideal requirements of a flap, however because of its flexibility, good blood supply and position it can be considered as the best among other flaps for reconstruction of oral and palatal defects...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28260147/establishment-and-characterization-of-a-squamous-cell-carcinoma-cell-line-designated-hzk-1-derived-from-a-metastatic-lymph-node-tumor-of-the-tongue
#4
Tetsuya Hirabayashi, Haruka Takahashi, Miho Watanabe, Toshiaki Tachibana
The hZK-1 cell line was successfully established from the metastatic foci of a lymph node of an 82-year-old Japanese woman with squamous cell carcinoma of the tongue. The pathological diagnosis of the tumor was moderately to well-differentiated squamous cell carcinoma. The hZK-1 cells were angular in shape, and had neoplastic and pleomorphic features. Adjacent hZK-1 cells were joined by desmosomes and well-developed microvilli, and many free ribosomes were observed in the cytoplasm. The doubling time of the hZK-1 cells was approximately 36, 33, and 29 h at the 10th, 20th, and 30th passages, respectively...
March 4, 2017: Human Cell
https://www.readbyqxmd.com/read/28229898/histomorphometric-characterization-of-subgemmal-neurogenous-plaques
#5
Ana Carolina Amorim Pellicioli, Felipe Paiva Fonseca, Rodrigo Neves Silva, Luiz Alcino Monteiro Gueiros, Oslei Paes de Almeida, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Helder Antonio Rebelo Pontes, Manoela Domingues Martins, Vinícius Coelho Carrard, Alan Roger Santos-Silva
OBJECTIVES: The aim of this study was to characterize the histomorphometric features of subgemmal neurogenous plaques (SNPs) to better understand their relationship to surrounding microanatomy included in the tissue biopsy samples of the tongue. STUDY DESIGN: A 12-year retrospective study on the files of 3 oral pathology centers yielded 28 SNPs. Hematoxylin and eosin-stained sections were used for histologic analysis, and immunohistochemical staining for S100 protein was performed to better characterize the neural structures...
January 9, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28215047/pharyngeal-swallowing-pressures-in-the-base-of-tongue-and-hypopharynx-regions-identified-with-three-dimensional-manometry
#6
Sarah P Rosen, Corinne A Jones, Timothy M McCulloch
OBJECTIVES: This study aims to use three-dimensional (3D) high-resolution manometry to identify circumferential pressure patterns generated within the asymmetrical base-of-tongue and hypopharynx regions of the pharynx during deglutition. STUDY DESIGN: Case series. METHODS: Radial pressures in the regions of interest were evaluated during swallowing events in 12 healthy subjects using 3D high-resolution manometry. RESULTS: Repeated measures analysis of variance revealed asymmetrical pharyngeal clearance pressures in the base-of-tongue and hypopharynx regions during swallowing...
February 19, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28210449/oral-mucosal-lesions-in-a-chilean-elderly-population-a-retrospective-study-with-a-systematic-review-from-thirteen-countries
#7
César Rivera, Daniel Droguett, María-Jesús Arenas-Márquez
BACKGROUND: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. MATERIAL AND METHODS: It was conducted a retrospective study (Talca, Chile)...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28209200/roles-of-preoperative-c-reactive-protein-are-more-relevant-in-buccal-cancer-than-other-subsites
#8
Shiao Fwu Tai, Huei-Tzu Chien, Chi-Kuang Young, Chung-Kang Tsao, Alba de Pablo, Kang-Hsing Fan, Chun-Ta Liao, Hung-Ming Wang, Chung-Jan Kang, Joseph Tung-Chieh Chang, Shiang-Fu Huang
BACKGROUND: C-reactive protein (CRP) is an early marker for inflammation, and a relationship between serum CRP levels and survival in oral cancer has been demonstrated previously. In this study, we investigated the roles of CRP in different oral cancer subsites. METHODS: Three hundred and forty-three oral squamous cell carcinoma patients between June 1999 and March 2015 were retrospectively reviewed. Serum CRP levels were measured preoperatively. RESULTS: The elevation of CRP levels (≥5...
February 16, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28122103/locoregional-control-of-tongue-base-adenoid-cystic-carcinoma-with-primary-resection-and-radial-forearm-free-flap-reconstruction
#9
Bharat B Yarlagadda, Josh C Meier, Derrick T Lin, Kevin S Emerick, Daniel G Deschler
Adenoid cystic carcinoma of the minor salivary glands can be challenging and marked by high rates of local recurrence despite appropriate surgical resection. Management of this pathology in the base of the tongue is particularly difficult given the poor functional outcomes traditionally associated with an aggressive surgical approach. This article presents a case series of patients who underwent up-front surgical resection followed by free tissue transfer reconstruction. A retrospective analysis was performed of patients with adenoid cystic carcinoma of the base of the tongue who underwent composite resection and reconstruction with a radial forearm free flap...
January 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28114406/identification-of-hpv-types-and-mycobacterium-tuberculosis-complex-in-historical-long-term-preserved-formalin-fixed-tissues-in-different-human-organs
#10
Maja Hühns, Andreas Erbersdobler, Annette Obliers, Paula Röpenack
University anatomical-pathological collections represent huge sources of human tissues and preparations from a variety of different diseases. With the help of modern genetic and histological methods, preserved fixed tissues from pathological collections can be used to re-evaluate former diagnoses. We analysed 25 specimens from our pathological collection with ages ranging from 78 to 112 years. The tissues originated from the oral cavity, lip, tongue, lung, bone, kidney, spleen, thymus, larynx, lymph node, penis and uterine cervix with an original diagnosis of epithelial cancers or tuberculosis...
2017: PloS One
https://www.readbyqxmd.com/read/28099223/median-lingual-lymph-nodes-prevalence-on-imaging-and-potential-implications-for-oral-cavity-cancer-staging
#11
Courtney M Tomblinson, Thomas H Nagel, Leland S Hu, Matthew A Zarka, Joseph M Hoxworth
OBJECTIVE: This study sought to estimate the prevalence of median lingual lymph node (MLLN) metastases from oral cavity squamous cell carcinoma (OCSCC) and determine the frequency with which MLLNs can be identified with magnetic resonance imaging (MRI) in control subjects. METHODS: Pathology reports were used to identify patients with surgically treated OCSCC who underwent preoperative positron emission tomography-computed tomography to define the prevalence of MLLN metastases...
January 18, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28097311/association-of-lymphovascular-space-invasion-with-locoregional-failure-and-survival-in-patients-with-node-negative-oral-tongue-cancers
#12
Richard J Cassidy, Jeffrey M Switchenko, Naresh Jegadeesh, Mutlay Sayan, Matthew J Ferris, Bree R Eaton, Kristin A Higgins, Jeffrey T Wadsworth, Kelly R Magliocca, Nabil F Saba, Jonathan J Beitler
Importance: The indications for adjuvant therapy in resected oral tongue cancers are based on both clinical and pathological factors, with clear evidence for adjuvant radiation in patients with pathologically positive neck lymph nodes, positive margins, and extracapsular extension, but the data for patients with no nodal disease are sparse. Objective: To investigate determinants of failure and survival in patients with node-negative oral tongue cancer. Design, Setting, and Participants: Medical records for patients with oral tongue cancer treated with definitive surgery from 2003 to 2013 were reviewed...
January 12, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28081307/the-demographics-and-histopathological-features-of-oral-cavity-cancers-in-turkey
#13
Mehmet Düzlü, Recep Karamert, Faruk Kadri Bakkal, Raşit Cevizci, Hakan Tutar, Mehmet Ekrem Zorlu, Alper Dilci, Fakih Cihat Eravcı
BACKGROUND/AIM: This study aimed to examine the demographics and histopathological features of oral cavity cancers (OCCs) managed in our clinic. MATERIALS AND METHODS: Patients who were diagnosed with OCCs in the Gazi University Otorhinolaryngology Department between the years 1993 and 2013 were retrospectively enrolled in the study. Surgical archive charts and pathology records were reviewed in detail regarding the anatomical and histopathological profiles of the tumors, as well as the demographic data of the patients...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28072991/-expression-of-oct4-and-sox2-and-their-clinical-significance-in-tongue-squamous-cell-carcinoma
#14
X D Jiang, G Luo, X H Wang, L L Chen, X Ke, Y Li
Objective: To investigate Oct4 and Sox2 protein expression in tongue squamous cell carcinoma (TSCC) and the relationships between the expressions of Oct4 and Sox2 and clinical pathological characteristics and survival of patients. Methods: The paraffin imbedded tissue specimens of 51 patients with histologically confirmed TSCC were included. Immunohistochemistry was employed to detect the protein expression of Oct4 and Sox2 in 51 TSCC tissue samples. The protein expression levels of Oct4 and Sox2 and their relationships with both clinicopathological features and survival of patients with TSCC were evaluated...
January 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28068276/repositioning-of-a-pathologically-migrated-tooth-using-autologous-platelet-rich-plasma-a-case-report-with-3-year-follow-up
#15
B V Karthikeyan, Divya Khanna, M Lv Prabhuji
An intricate balance between the periodontal tissues and the forces of occlusion, tongue, and lips helps to maintain a tooth in its physiologic position within the dental arch. Disturbances in the equilibrium can cause a tooth to migrate pathologically, often requiring multidisciplinary treatment approaches. The present case demonstrates, for the first time, the use of autologous platelet-rich plasma to aid in tooth repositioning after pathologic tooth migration. A 25-year-old woman presented with extrusion and labial migration of the maxillary left central incisor, a diastema of 3 mm, and grade II mobility...
January 2017: General Dentistry
https://www.readbyqxmd.com/read/28061358/prognostic-factors-of-oral-squamous-cell-carcinoma-in-young-patients-a-systematic-review
#16
REVIEW
Everton Freitas de Morais, Rodrigo Porpino Mafra, Amanda Katarinny Goes Gonzaga, Dyego Leandro Bezerra de Souza, Leão Pereira Pinto, Éricka Janine Dantas da Silveira
PURPOSE: The objective of this review was to identify clinical and pathologic factors related to the prognosis of oral squamous cell carcinoma in young patients. MATERIALS AND METHODS: We conducted a literature search of articles indexed in PubMed (MEDLINE), Scopus, and Science Direct. Prospective and retrospective cohort studies published in English, Portuguese, or Spanish were included. An age threshold of 45 years was established for the purpose of selection...
December 21, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28060365/newly-described-salivary-gland-tumors
#17
Alena Skalova, Michal Michal, Roderick Hw Simpson
This review concentrates on three salivary gland tumors that have been accepted in the recent literature as new neoplastic entities: mammary analog secretory carcinoma (MASC), sclerosing polycystic adenoma (SPA) and cribriform adenocarcinoma of tongue and other minor salivary glands (CAMSGs). MASC is a distinctive low-grade malignant salivary cancer that harbors a characteristic chromosomal translocation, t(12;15) (p13;q25) resulting in an ETV6-NTRK3 fusion. SPA is a rare lesion often mistaken histologically for low-grade salivary carcinoma...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28059707/ct-accuracy-of-extrinsic-tongue-muscle-invasion-in-oral-cavity-cancer
#18
J C Junn, K L Baugnon, E A Lacayo, P A Hudgins, M R Patel, K R Magliocca, A S Corey, M El-Deiry, J T Wadsworth, J J Beitler, N F Saba, Y Liu, A H Aiken
BACKGROUND AND PURPOSE: Extrinsic tongue muscle invasion in oral cavity cancer upstages the primary tumor to a T4a. Despite this American Joint Committee on Cancer staging criterion, no studies have investigated the accuracy or prognostic importance of radiologic extrinsic tongue muscle invasion, the feasibility of standardizing extrinsic tongue muscle invasion reporting, or the degree of agreement across different disciplines: radiology, surgery, and pathology. The purpose of this study was to assess the agreement among radiology, surgery, and pathology for extrinsic tongue muscle invasion and to determine the imaging features most predictive of extrinsic tongue muscle invasion with surgical/pathologic confirmation...
November 10, 2016: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28047176/su-c-bra-05-delineating-high-dose-clinical-target-volumes-for-head-and-neck-tumors-using-machine-learning-algorithms
#19
C Cardenas, A Wong, A Mohamed, J Yang, L Court, A Rao, C Fuller, M Aristophanous
PURPOSE: To develop and test population-based machine learning algorithms for delineating high-dose clinical target volumes (CTVs) in H&N tumors. Automating and standardizing the contouring of CTVs can reduce both physician contouring time and inter-physician variability, which is one of the largest sources of uncertainty in H&N radiotherapy. METHODS: Twenty-five node-negative patients treated with definitive radiotherapy were selected (6 right base of tongue, 11 left and 9 right tonsil)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046847/su-g-iep1-05-diffusion-kurtosis-imaging-for-oropharyngeal-cancer-detection
#20
Y Ding, A Mohamed, J Ma, S Frank, J Wang, C Fuller
PURPOSE: Diffusion kurtosis imaging (DKI) is an emerging diffusion MRI technique in cancer diagnosis applications. The objective of this study is to compare DKI with conventional diffusion weighted imaging (DWI) for diagnosis of head and neck cancer. METHODS: Five male patients with histologically documented phase II/III squamous cell carcinoma of the oropharynx were included in this study. DKI (with 6 b-values of 0-2000 s/mm2) and conventional DWI data were acquired at a 3...
June 2016: Medical Physics
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