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https://www.readbyqxmd.com/read/28526255/associations-of-objective-and-subjective-sleep-disturbance-with-cognitive-function-in-older-men-with-comorbid-depression-and-insomnia
#1
Daniel J Biddle, Sharon L Naismith, Kathleen M Griffiths, Helen Christensen, Ian B Hickie, Nicholas S Glozier
OBJECTIVES: To examine whether poor objective and subjective sleep quality are differentially associated with cognitive function. DESIGN: Cross-sectional. SETTING: Participants were recruited from primary and secondary care, and directly from the community, in Sydney, Australia. PARTICIPANTS: The sample consisted of 74 men 50years and older (mean [SD], 58.4 [6.2] years), with comorbid depression and above-threshold insomnia symptoms, participating in a trial of online cognitive behavioral therapy for insomnia...
June 2017: Sleep Health
https://www.readbyqxmd.com/read/28525632/effect-of-baseline-characteristics-on-the-pain-response-to-pregabalin-in-fibromyalgia-patients-with-comorbid-depression
#2
Stuart L Silverman, Miroslav Backonja, Lynne Pauer, Jaren Landen, Pritha Bhadra Brown, Joseph M Scavone, Richard Vissing, Andrew Clair
Objective. : To evaluate the effect of baseline characteristics on the treatment response to pregabalin in fibromyalgia (FM) patients with depression. Design. : Post hoc analysis from a randomized, double-blind, placebo-controlled, two-way crossover study of pregabalin (300 or 450 mg/day, twice daily). Subjects. : A total of 193 FM patients taking an antidepressant for comorbid depression. Methods. : The effect of patient baseline characteristics on the treatment response to pregabalin vs placebo was assessed for the primary efficacy end point (mean pain score on an 11-point numeric rating scale)...
May 19, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28522080/treatment-of-insomnia-with-tricyclic-antidepressants-a-meta-analysis-of-polysomnographic-randomized-controlled-trials
#3
REVIEW
Yang Liu, Xiaomin Xu, Meixue Dong, Shiyu Jia, Youdong Wei
BACKGROUND: Insomnia represents a significant public health burden worldwide. Antidepressants have often been the insomnia treatment of choice in recent decades. Some tricyclic antidepressants (TCAs) have been shown to improve sleep efficiency. OBJECTIVE: Assess the efficacy and safety of TCAs for the treatment of insomnia using a meta-analysis of randomized control trials (RCTs). METHODS: Relevant studies were identified in electronic databases such as PubMed, Cochrane, Embase, and Web of Science, up until July 2016...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28521579/cognitive-behavioural-therapy-for-post-stroke-fatigue-and-sleep-disturbance-a-pilot-randomised-controlled-trial-with-blind-assessment
#4
Sylvia Nguyen, Dana Wong, Adam McKay, Shantha M W Rajaratnam, Gershon Spitz, Gavin Williams, Darren Mansfield, Jennie L Ponsford
The objective of this study was to evaluate the effectiveness of individual cognitive behavioural therapy (CBT) for post-stroke fatigue and sleep disturbance compared to treatment as usual (TAU). In a parallel two-group pilot randomised controlled trial of 15 participants, nine were allocated to eight weekly sessions of adapted CBT and six continued usual care rehabilitation. The primary outcome was the Fatigue Severity Scale (FSS-7) at two and four months from baseline. Secondary outcomes included measures of sleep, mood and quality of life...
May 19, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28513073/early-neurocognitive-improvements-following-parathyroidectomy-for-primary-hyperparathyroidism
#5
Shivani Shah-Becker, Jonathan Derr, Benjamin S Oberman, Aaron Baker, Brian Saunders, Michele M Carr, David Goldenberg
OBJECTIVES: To establish a time frame for postoperative improvements in neurocognitive function in patients who undergo parathyroidectomy for primary hyperparathyroidism by utilizing repeat neuropsychological assessment at multiple time points before and after surgery. STUDY DESIGN: Prospective cohort study. METHODS: A prospective study was conducted at a tertiary academic medical center between August 2014 and December 2015, including 50 patients with primary hyperparathyroidism who underwent parathyroidectomy...
May 16, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28512389/evaluation-of-quality-of-life-at-progression-in-patients-with-soft-tissue-sarcoma
#6
Stacie Hudgens, Anna Forsythe, Ilias Kontoudis, David D'Adamo, Ashley Bird, Hans Gelderblom
Introduction. Soft Tissue Sarcoma (STS) is a rare malignancy of mesodermal tissue, with international incidence estimates between 1.8 and 5 per 100,000 per year. Understanding quality of life (QoL) and the detrimental impact of disease progression is critical for long-term care and survival. Objectives. The primary objective was to explore the relationship between disease progression and health-related quality of life (HRQoL) using data from Eisai's study (E7389-G000-309). Methods. This was a 1 : 1 randomized, open-label, multicenter, Phase 3 study comparing the efficacy and safety of eribulin versus dacarbazine in patients with advanced STS...
2017: Sarcoma
https://www.readbyqxmd.com/read/28508735/sleep-problems-in-breast-cancer-survivors-1-10-years-posttreatment
#7
Amy E Lowery-Allison, Steven D Passik, Matthew R Cribbet, Ruth A Reinsel, Barbara O'Sullivan, Larry Norton, Kenneth L Kirsh, Neil B Kavey
OBJECTIVE: Sleep can affect quality of life (QoL) during cancer survivorship, and symptoms related to poor sleep can be exacerbated. We examined the prevalence, severity, and nature of subjective sleep complaints in women surviving stage I-III breast cancer who were 1-10 years posttreatment. We also examined the demographic, medical, physical, and psychosocial correlates of poor sleep in these women in order to identify the subgroups that may be most in need of intervention. METHOD: A total of 200 patients at a comprehensive cancer center who were 1-10 years posttreatment for primary stage I-III breast cancer with no evidence of disease at the time of enrollment completed a battery of questionnaires on demographics, sleep, physical symptoms, mood, cancer-specific fears, and QoL...
May 16, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28500965/resting-state-functional-connectivity-in-primary-insomnia-generalized-anxiety-disorder-and-controls
#8
Edward F Pace-Schott, Jared P Zimmerman, Ryan M Bottary, Erik G Lee, Mohammed R Milad, Joan A Camprodon
Sleep abnormalities are extremely common in anxiety disorders and may contribute to their development and persistence. Their shared pathophysiological mechanisms could thus serve as biomarkers or targets for novel therapeutics. Individuals with Primary Insomnia were age- and sex-matched to controls and to persons with Generalized Anxiety Disorder. All underwent fMRI resting-state scans at 3-T. In Primary Insomnia and controls, sleep was recorded for 2 weeks using diaries and actigraphy. All participants completed state-anxiety and neuroticism inventories...
May 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28500199/data-quality-in-electronic-medical-records-in-manitoba-do-problem-lists-reflect-chronic-disease-as-defined-by-prescriptions
#9
Alexander Singer, Andrea L Kroeker, Sari Yakubovich, Roberto Duarte, Brenden Dufault, Alan Katz
OBJECTIVE: To determine if the problem list (health conditions) in primary care electronic medical records (EMRs) accurately reflects the conditions for which chronic medications are prescribed in the EMR. DESIGN: A retrospective analysis of EMR data. SETTING: Eighteen primary care clinics across rural and urban Manitoba using the Accuro EMR. PARTICIPANTS: Data from the EMRs of active patients seen in an 18-month period (December 18, 2011, to June 18, 2013, or December 3, 2012, to June 3, 2014) were used...
May 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28498551/sofosbuvir-velpatasvir-with-ribavirin-for-24-weeks-in-hcv-patients-previously-treated-with-a-direct-acting-antiviral-regimen
#10
Edward J Gane, Mitchell L Shiffman, Kyle Etzkorn, Giuseppe Morelli, Catherine Stedman, Mitchell N Davis, Federico Hinestrosa, Hadas Dvory-Sobol, K C Huang, Anu Osinusi, John McNally, Diana M Brainard, John G McHutchison, Alex J Thompson, Mark S Sulkowski
The optimal retreatment strategy for patients chronically infected with hepatitis C virus (HCV) who experience virologic failure after treatment with direct-acting antiviral (DAA)-based therapies remains unclear. In this multicenter, open-label, phase 2 study, we evaluated the efficacy and safety of a fixed-dose combination of sofosbuvir-velpatasvir (400 mg/100 mg) plus weight-adjusted ribavirin administered for 24 weeks in patients who did not achieve sustained virologic response (SVR) after prior treatment with DAA regimens that included the nucleotide analogue NS5B inhibitor sofosbuvir plus the NS5A inhibitor velpatasvir with or without the NS3/4A protease inhibitor voxilaprevir...
May 12, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28489508/tai-chi-chih-compared-with-cognitive-behavioral-therapy-for-the-treatment-of-insomnia-in-survivors-of-breast-cancer-a-randomized-partially-blinded-noninferiority-trial
#11
Michael R Irwin, Richard Olmstead, Carmen Carrillo, Nina Sadeghi, Perry Nicassio, Patricia A Ganz, Julienne E Bower
Purpose Cognitive behavioral therapy for insomnia (CBT-I) and Tai Chi Chih (TCC), a movement meditation, improve insomnia symptoms. Here, we evaluated whether TCC is noninferior to CBT-I for the treatment of insomnia in survivors of breast cancer. Patients and Methods This was a randomized, partially blinded, noninferiority trial that involved survivors of breast cancer with insomnia who were recruited from the Los Angeles community from April 2008 to July 2012. After a 2-month phase-in period with repeated baseline assessment, participants were randomly assigned to 3 months of CBT-I or TCC and evaluated at months 2, 3 (post-treatment), 6, and 15 (follow-up)...
May 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28484661/cognitive-function-characteristics-of-parkinson-s-disease-with-sleep-disorders
#12
Jing Huang, Wenyan Zhuo, Yuhu Zhang, Hongchun Sun, Huan Chen, Peipei Zhu, Xiaobo Pan, Jianhao Yang, Lijuan Wang
Objective. The aim of this study was to investigate the cognitive function characteristics of Parkinson's disease (PD) with sleep disorders. Methods. Consecutive patients with PD (n = 96), patients with primary sleep disorders (n = 76), and healthy control subjects (n = 66) were assessed. The patients with PD were classified into sleep disorder (PD-SD) and non-sleep disorder (PD-NSD) groups. Results. Among 96 patients with PD, 69 were diagnosed with a sleep disorder. There were 38 sleep disorder cases, 31 RBD cases, and 27 NSD cases...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28481729/anticonvulsant-drugs-for-generalized-tonic-clonic-epilepsy
#13
Giangennaro Coppola, Alessandra Piccorossi, Francesca Felicia Operto, Alberto Verrotti
Primary generalized tonic clonic seizures (pGTCS) are still linked to major concerns for the clinic and hazards for patients suffering from idiopathic generalized epilepsy (IGE), so a quick search of the most effective and appropriate therapy is needed to control them. The key criteria for proper treatment are syndromic diagnosis and distinction between newly diagnosed and refractory patients. Other criteria include age, gender and comorbidities. Areas covered: Treatment for pGTCS has expanded in the last two years, with new antiepileptic drugs like perampanel joining valproic acid, lamotrigine, levetiracetam, topiramate, while further evidence-based data are required for zonisamide and lacosamide...
June 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28474653/raising-awareness-about-sleep-disorders
#14
REVIEW
Stuti J Jaiswal, Robert L Owens, Atul Malhotra
Sleep disorders affect a substantial number of people worldwide and may be increasing in prevalence. Unfortunately, many of these disorders can go unrecognized and untreated in clinical practice. Although physicians understand that good sleep is essential to patient health, approaching the issue is often glossed over in the primary care setting. Importantly, recent data also suggest that sleep disorders are becoming increasingly recognized in developing nations. Here, we review the pertinent features and treatment of some of the major sleep disorders, including obstructive sleep apnea, central sleep apnea, insomnia, and others, that affect patient health...
May 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28473869/common-mental-disorder-and-its-association-with-academic-performance-among-debre-berhan-university-students-ethiopia
#15
Yohannes Gebreegziabhere Haile, Sisay Mulugeta Alemu, Tesfa Dejenie Habtewold
BACKGROUND: Common mental disorder (CMD) is prevalent in industrialized and non-industrialized countries. The prevalence of CMD among university students was 28.8-44.7% and attributed to several risk factors, such as schooling. The aim of this study was to assess the prevalence and risk factors of CMD. In addition, the association between CMD and academic performance was tested. METHODS: Institution based cross-sectional study was conducted with 422 students at Debre Berhan university from March to April 2015...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28463021/identifying-the-demographic-and-mental-health-factors-that-influence-insomnia-treatment-recommendations-within-a-veteran-population
#16
Adam D Bramoweth, Jenna G Renqvist, Barbara H Hanusa, Jon D Walker, Anne Germain, Charles W Atwood
OBJECTIVE/BACKGROUND: Insomnia is a pervasive and costly disorder that is particularly prevalent within the U.S. Veteran population. Although Cognitive Behavioral Therapy for Insomnia (CBT-I) is the recommended first-line treatment for insomnia, high rates of sedative-hypnotic prescribing continue. There is little research investigating the rates and factors impacting insomnia treatment recommendations, both behavioral and pharmacological. PARTICIPANTS: A cohort of 5,254 Veterans referred for either CBT-I or prescribed a sedative-hypnotic medication at a single VA Medical Center composed the group of participants...
May 2, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28463015/effectiveness-of-group-cognitive-behavioral-therapy-for-insomnia-cbt-i-in-a-primary-care-setting
#17
Judith R Davidson, Samantha Dawson, Adrijana Krsmanovic
OBJECTIVE/BACKGROUND: Primary care is where many patients with insomnia first ask for professional help. Cognitive-behavioral therapy for insomnia (CBT-I) is the recommended treatment for chronic insomnia. Although CBT-I's efficacy is well established, its effectiveness in real-life primary care has seldom been investigated. We examined the effectiveness of CBT-I as routinely delivered in a Canadian primary care setting. PARTICIPANTS: The patients were 70 women and 11 men (mean age = 57...
May 2, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28459898/high-prevalence-of-inappropriate-benzodiazepine-and-sedative-hypnotic-prescriptions-among-hospitalized-older-adults
#18
Elisabeth Anna Pek, Andrew Remfry, Ciara Pendrith, Chris Fan-Lun, R Sacha Bhatia, Christine Soong
BACKGROUND: Benzodiazepines and sedative hypnotics are commonly used to treat insomnia and agitation in older adults despite significant risk. A clear understanding of the extent of the problem and its contributors is required to implement effective interventions. OBJECTIVE: To determine the proportion of hospitalized older adults who are inappropriately prescribed benzodiazepines or sedative hypnotics, and to identify patient and prescriber factors associated with increased prescriptions...
May 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28456026/quality-of-life-in-chinese-patients-with-schizophrenia-treated-in-primary-care
#19
Yan Li, Cai-Lan Hou, Xin-Rong Ma, Bao-Liang Zhong, Yu Zang, Fu-Jun Jia, Yong-Qiang Lin, Kelly Y C Lai, Helen F K Chiu, Gabor S Ungvari, Brian J Hall, Mei-Ying Cai, Chee H Ng, Yu-Tao Xiang
In China, maintenance treatment for clinically stable patients with schizophrenia is usually provided by primary care physicians. This study examined the quality of life (QOL) in patients with schizophrenia treated in primary care and explored the demographic and clinical characteristics associated with QOL. Altogether, 612 patients with schizophrenia treated in 22 randomly selected primary care services in China formed the study sample. QOL, psychotic and depressive symptoms, extra-pyramidal symptoms and insight were assessed using standardized instruments...
April 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28450891/adrenocorticotropic-hormone-versus-methylprednisolone-added-to-interferon-%C3%AE-in-patients-with-multiple-sclerosis-experiencing-breakthrough-disease-a-randomized-rater-blinded-trial
#20
Regina Berkovich, Rohit Bakshi, Lilyana Amezcua, Robert C Axtell, Steven Y Cen, Shahamat Tauhid, Mohit Neema, Lawrence Steinman
BACKGROUND: The objective of this study was to evaluate monthly intramuscular adrenocorticotropic hormone (ACTH) gel versus intravenous methylprednisolone (IVMP) add-on therapy to interferon β for breakthrough disease in patients with relapsing forms of multiple sclerosis. METHODS: This was a prospective, open-label, examiner-blinded, 15-month pilot study evaluating patients with Expanded Disability Status Scale (EDSS) score 3.0-6.5 and at least one clinical relapse or new T2 or gadolinium-enhanced lesion in the previous year...
January 2017: Therapeutic Advances in Neurological Disorders
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