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Primary insomnia

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https://www.readbyqxmd.com/read/28712074/efficacy-and-safety-of-shp465-mixed-amphetamine-salts-in-the-treatment-of-attention-deficit-hyperactivity-disorder-in-adults-results-of-a-randomized-double-blind-placebo-controlled-forced-dose-clinical-study
#1
Richard H Weisler, Michael Greenbaum, Valerie Arnold, Ming Yu, Brian Yan, Margo Jaffee, Brigitte Robertson
OBJECTIVE: The objective of this randomized, double-blind, placebo-controlled study was to evaluate the efficacy and safety of SHP465 mixed amphetamine salts (MAS) in adults with attention-deficit/hyperactivity disorder (ADHD). METHODS: Eligible adults [aged 18-55 years; meeting the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition ADHD criteria; baseline ADHD Rating Scale with Adult Prompts (ADHD-RS-AP) total scores ≥28] were randomized 1:1:1 to placebo or forced-dose SHP465 MAS (12...
July 15, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28709078/insomnia-in-people-with-epilepsy-a-review-of-insomnia-prevalence-risk-factors-and-associations-with-epilepsy-related-factors
#2
REVIEW
Philippe Joaquim Oliveira Menezes Macêdo, Pedro Sudbrack de Oliveira, Nancy Foldvary-Schaefer, Marleide da Mota Gomes
BACKGROUND: Insomnia is a common sleep complaint in the general population, and sleep loss may be a trigger for epileptic seizures. OBJECTIVES: To conduct a comprehensive review of the literature of insomnia symptoms and insomnia disorder, their prevalence and epilepsy-related risk factors in people with epilepsy (PWE). METHODS: A PUBMED search was performed for articles indexed to June 2016 involving human subjects, excluding papers in languages other than English, Spanish and Portuguese and case reports...
June 3, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28702268/distressing-visual-hallucinations-after-treatment-with-trazodone
#3
Gustavo Santos, Ana Maria Moreira
Trazodone, a second-generation atypical antidepressant, is increasingly being used off-label, in the treatment of insomnia. Although generally well tolerated, trazodone treatment can be associated with some complications. We describe a case of a 60-year-old man who received trazodone for primary insomnia. He returned, to the emergency department, two days later with distressing visual hallucinations, which prompted inpatient treatment. Trazodone was discontinued, leading to a complete resolution of his visual hallucinations, and he was treated with mirtazapine for 6 months...
2017: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/28701993/no-impaired-glucose-tolerance-in-primary-insomnia-patients-with-normal-results-of-polysomnography
#4
Johanna Tschepp, Christoph J Lauer, Johanna Wilde-Frenz, Thomas Pollmächer
BACKGROUND: According to recent studies, sleep restriction and disruption both have a prominent negative influence on glucose metabolism. This could also be shown in sleep disorders, such as sleep apnea and the restless legs syndrome. However, similar studies regarding insomnia have not been that consistent, yet. Moreover, most previous studies did not include objective polysomnography (PSG) data. METHODS: Patients with primary insomnia (N = 17) and healthy controls (N = 15) were investigated using psychometric tests such as the Epworth Sleepiness Scale and the Pittsburgh sleep quality index (PSQI)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28700715/the-pharmacological-and-non-pharmacological-treatment-of-attention-deficit-hyperactivity-disorder-in-children-and-adolescents-a-systematic-review-with-network-meta-analyses-of-randomised-trials
#5
Ferrán Catalá-López, Brian Hutton, Amparo Núñez-Beltrán, Matthew J Page, Manuel Ridao, Diego Macías Saint-Gerons, Miguel A Catalá, Rafael Tabarés-Seisdedos, David Moher
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is one of the most commonly diagnosed psychiatric disorders in childhood. A wide variety of treatments have been used for the management of ADHD. We aimed to compare the efficacy and safety of pharmacological, psychological and complementary and alternative medicine interventions for the treatment of ADHD in children and adolescents. METHODS AND FINDINGS: We performed a systematic review with network meta-analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28656632/serum-brain-derived-neurotrophic-factor-bdnf-in-sleep-disordered-patients-relation-to-sleep-stage-n3-and-rapid-eye-movement-rem-sleep-across-diagnostic-entities
#6
Michael Deuschle, Michael Schredl, Christian Wisch, Claudia Schilling, Maria Gilles, Olga Geisel, Rainer Hellweg
Experimental and clinical evidence suggests an association between neuroplasticity, brain-derived neurotrophic factor and sleep. We aimed at testing the hypotheses that brain-derived neurotrophic factor is associated with specific aspects of sleep architecture or sleep stages in patients with sleep disorders. We included 35 patients with primary insomnia, 31 patients with restless legs syndrome, 17 patients with idiopathic hypersomnia, 10 patients with narcolepsy and 37 healthy controls. Morning serum brain-derived neurotrophic factor concentrations were measured in patients and controls...
June 28, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28655183/three-year-follow-up-comparing-cognitive-behavioral-therapy-for-depression-to-cognitive-behavioral-therapy-for-insomnia-for-patients-with-both-diagnoses
#7
Kerstin Blom, Susanna Jernelöv, Christian Rück, Nils Lindefors, Viktor Kaldo
This three-year follow-up compared insomnia treatment to depression treatment for patients with both diagnoses. Forty-three participants were randomized to either treatment, in the form of Internet-delivered therapist-guided cognitive behavior therapy, and 37 (86%) provided primary outcome data at the three-year follow-up. After three years, reductions on depression severity were similar in both groups (between-group effect-size, d = 0.33, p = .45), while the insomnia treatment had superior effects on insomnia severity (d = 0...
June 24, 2017: Sleep
https://www.readbyqxmd.com/read/28652745/regional-impairment-of-intrinsic-functional-connectivity-strength-in-patients-with-chronic-primary-insomnia
#8
Suhua Huang, Fuqing Zhou, Jian Jiang, Muhua Huang, Xianjun Zeng, Shan Ding, Honghan Gong
Several neuroimaging studies have suggested that brain impairment and plasticity occur in patients with chronic primary insomnia (CPI); however, the effects of insomnia on the intrinsic organization of the brain remain largely unknown. In this study, a voxel-based functional connectivity strength (FCS) assessment, a data-driven method based on a theoretical approach, was applied to investigate the effects of insomnia on the intrinsic organization of the whole brain in 27 treatment-naïve CPI patients and 26 well-matched healthy controls (HCs)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28649490/frequency-dependent-changes-in-local-intrinsic-oscillations-in-chronic-primary-insomnia-a-study-of-the-amplitude-of-low-frequency-fluctuations-in-the-resting-state
#9
Fuqing Zhou, Suhua Huang, Ying Zhuang, Lei Gao, Honghan Gong
New neuroimaging techniques have led to significant advancements in our understanding of cerebral mechanisms of primary insomnia. However, the neuronal low-frequency oscillation remains largely uncharacterized in chronic primary insomnia (CPI). In this study, the amplitude of low-frequency fluctuation (ALFF), a data-driven method based on resting-state functional MRI, was used to examine local intrinsic activity in 27 patients with CPI and 27 age-, sex-, and education-matched healthy controls. We examined neural activity in two frequency bands, slow-4 (between 0...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28648359/evidence-for-the-efficacy-of-melatonin-in-the-treatment-of-primary-adult-sleep-disorders
#10
REVIEW
Fiona Auld, Emily L Maschauer, Ian Morrison, Debra J Skene, Renata L Riha
Melatonin is a physiological hormone involved in sleep timing and is currently used exogenously in the treatment of primary and secondary sleep disorders with empirical evidence of efficacy, but very little evidence from randomised, controlled studies. The aim of this meta-analysis was to assess the evidence base for the therapeutic effects of exogenous melatonin in treating primary sleep disorders. An electronic literature review search of MEDLINE (1950-present) Embase (1980- present), PsycINFO (1987- present), and Scopus (1990- present), along with a hand-searching of key journals was performed in July 2013 and then again in May 2015...
July 20, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28647747/comparing-the-effects-of-mindfulness-based-cognitive-therapy-and-sleep-psycho-education-with-exercise-on-chronic-insomnia-a-randomised-controlled-trial
#11
Samuel Yeung-Shan Wong, De-Xing Zhang, Carole Chi-Kwan Li, Benjamin Hon-Kei Yip, Dicken Cheong-Chun Chan, Yuet-Man Ling, Cola Siu-Lin Lo, Doris Mei-Sum Woo, Yu-Ying Sun, Helen Ma, Winnie Wing-Sze Mak, Ting Gao, Tatia Mei-Chun Lee, Yun-Kwok Wing
BACKGROUND: Mindfulness-based cognitive therapy (MBCT) is a potential treatment for chronic insomnia. We evaluated the efficacy of MBCT for insomnia (MBCT-I) by comparing it with a sleep psycho-education with exercise control (PEEC) group. METHODS: Adults with chronic primary insomnia (n = 216) were randomly allocated to the MBCT-I or PEEC group. The MBCT-I included mindfulness and psycho-education with cognitive and behavioural components under cognitive behavioural therapy for insomnia...
2017: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/28631980/orexin-research-patent-news-from-2016
#12
Christoph Boss, Catherine Roch
The orexin system consists of two G-protein-coupled receptors, orexin 1 and orexin 2 and two endogenous ligands, orexin A and orexin B . It is evolutionarily highly conserved. It is involved in the promotion of wakefulness as well as in anxiety and addictive disorders. In addition, its activation via the Ox1 receptor triggers apoptosis in several cancer cell lines. Dual orexin receptor antagonists are successfully used to treat primary insomnia. The major open questions are now related to the clinical validation of Ox1 selective antagonists...
June 28, 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/28629294/prevalence-of-insomnia-and-related-impact
#13
Manchumad Manjavong, Panita Limpawattana, Pisaln Mairiang, Sirirat Anutrakulchai
Background Sleep problem is a common geriatric condition that can result in various outcomes, both physical and mental, that reduce quality of life. The studies regarding the prevalence and impact of insomnia on daily activities in Thailand in pre-elderly and elderly adults are few. Objectives The primary objective of this study was to determine the prevalence of insomnia among pre-elderly and elderly populations and the secondary objective was to study the impact of insomnia on their daily lives. Methods This study included the participants from the urban middle class in the pre-retirement age of 50 years or older adults who worked for Khon Kaen University (KKU), Khon Kaen, Thailand, and their elderly relatives...
August 2016: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28623947/effects-of-digital-cognitive-behavioural-therapy-for-insomnia-on-cognitive-function-study-protocol-for-a-randomised-controlled-trial
#14
Simon D Kyle, Madeleine E D Hurry, Richard Emsley, Annemarie I Luik, Ximena Omlin, Kai Spiegelhalder, Colin A Espie, Claire E Sexton
BACKGROUND: The daytime effects of insomnia pose a significant burden to patients and drive treatment seeking. In addition to subjective deficits, meta-analytic data show that patients experience reliable objective impairments across several cognitive domains. While Cognitive Behavioural Therapy for Insomnia (CBT-I) is an effective and scalable treatment, we know little about its impact upon cognitive function. Trials of CBT-I have typically used proxy measures for cognitive functioning, such as fatigue or work performance scales, and no study has assessed self-reported impairment in cognitive function as a primary outcome...
June 17, 2017: Trials
https://www.readbyqxmd.com/read/28619476/brexanolone-sage-547-injection-in-post-partum-depression-a-randomised-controlled-trial
#15
Stephen Kanes, Helen Colquhoun, Handan Gunduz-Bruce, Shane Raines, Ryan Arnold, Amy Schacterle, James Doherty, C Neill Epperson, Kristina M Deligiannidis, Robert Riesenberg, Ethan Hoffmann, David Rubinow, Jeffrey Jonas, Steven Paul, Samantha Meltzer-Brody
BACKGROUND: Post-partum depression is a serious mood disorder in women that might be triggered by peripartum fluctuations in reproductive hormones. This phase 2 study investigated brexanolone (USAN; formerly SAGE-547 injection), an intravenous formulation of allopregnanolone, a positive allosteric modulator of γ-aminobutyric acid (GABAA) receptors, for the treatment of post-partum depression. METHODS: For this double-blind, randomised, placebo-controlled trial, we enrolled self-referred or physician-referred female inpatients (≤6 months post partum) with severe post-partum depression (Hamilton Rating Scale for Depression [HAM-D] total score ≥26) in four hospitals in the USA...
June 12, 2017: Lancet
https://www.readbyqxmd.com/read/28606497/validity-of-a-commercial-wearable-sleep-tracker-in-adult-insomnia-disorder-patients-and-good-sleepers
#16
Seung-Gul Kang, Jae Myeong Kang, Kwang-Pil Ko, Seon-Cheol Park, Sara Mariani, Jia Weng
OBJECTIVES: To compare the accuracy of the commercial Fitbit Flex device (FF) with polysomnography (PSG; the gold-standard method) in insomnia disorder patients and good sleepers. METHODS: Participants wore an FF and actigraph while undergoing overnight PSG. Primary outcomes were intraclass correlation coefficients (ICCs) of the total sleep time (TST) and sleep efficiency (SE), and the frequency of clinically acceptable agreement between the FF in normal mode (FFN) and PSG...
June 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28603433/evaluation-of-effectiveness-and-safety-of-a-herbal-compound-in-primary-insomnia-symptoms-and-sleep-disturbances-not-related-to-medical-or-psychiatric-causes
#17
Giancarlo Palmieri, Paola Contaldi, Giuseppe Fogliame
BACKGROUND AND PURPOSE: Sleep disturbances and related daytime activities impairment are common diseases nowadays. General practitioners are often the first health care professional asked to alleviate sleep disturbances and primary insomnia symptoms. Beyond a wide class of hypnotic drugs, botanicals can represent an alternative treatment for those kinds of symptoms. The scope of the present study is to evaluate safety and effectiveness of a herbal compound composed of valerian, hop, and jujube (Vagonotte(®)) on primary insomnia symptoms and sleep disturbances not related to medical or psychiatric causes...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/28592979/sleep-problems-in-children-and-adolescents-at-pediatric-clinics
#18
Dong Soon Kim, Cho Long Lee, Young Min Ahn
PURPOSE: To investigate the frequency of childhood sleep problems at pediatric clinics in Seoul and Gyeonggi provinces. METHODS: Children (n=936) and their parents who visited 5 primary and 1 secondary pediatric outpatient clinics were invited to complete a Pediatric Sleep Questionnaire. RESULTS: Among patients, 901 (96.3%) answered questionnaires in sufficient detail for evaluation. The participant's mean age was 4.35±3.02 years (range, 0-18 years)...
May 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/28591386/impact-of-insomnia-on-self-perceived-health-in-the-elderly
#19
Janiciene Silva, Annibal Truzzi, Fayanne Schaustz, Roberta Barros, Marisa Santos, Jerson Laks
Objective: To investigate the association between self-perceived health, and sociodemographic and clinical factors in a sample of elderly outpatients in Rio de Janeiro. Methods: A sample of 345 elderly patients was assessed with an anamnesis, Lawton and Brody's Scale, Katz Index, Geriatric Depression Scale, Timed Up and Go Test, and Study of Osteoporotic Fracture Index. Logistic regression analyses were performed to investigate the predictors of self-perceived health...
May 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/28587609/hypertension-with-unsatisfactory-sleep-health-hush-study-protocol-for-a-randomized-controlled-trial
#20
Jessica C Levenson, Bruce L Rollman, Lee M Ritterband, Patrick J Strollo, Kenneth J Smith, Jonathan G Yabes, Charity G Moore, Allison G Harvey, Daniel J Buysse
BACKGROUND: Insomnia is common in primary care medical practices. Although behavioral treatments for insomnia are safe, efficacious, and recommended in practice guidelines, they are not widely-available, and their effects on comorbid medical conditions remain uncertain. We are conducting a pragmatic clinical trial to test the efficacy of two cognitive behavioral treatments for insomnia (Brief Behavioral Treatment for Insomnia (BBTI) and Sleep Healthy Using the Internet (SHUTi)) versus an enhanced usual care condition (EUC)...
June 6, 2017: Trials
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