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https://www.readbyqxmd.com/read/27919020/psychosocial-factors-associated-with-migraine-and-tension-type-headache-in-medical-students
#1
Elena R Lebedeva, Natalia R Kobzeva, Denis V Gilev, Nadezhda V Kislyak, Jes Olesen
BACKGROUND: In our previous study of workers, blood donors and medical students, students stood out with a higher 1-year prevalence of migraine (28%) and tension-type headache (TTH) (74%). General factors associated with headache were common for all groups except low physical activity. The hypothesis of this study was therefore that a number of psychosocial factors relating to the personal sphere would better explain the high prevalence of migraine and TTH in students. METHODS: The study population consisted of 1042 students (719 females, 323 males, mean age 20...
November 8, 2016: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/27909987/orexin-ox2-receptor-antagonists-as-sleep-aids
#2
Laura H Jacobson, Sui Chen, Sanjida Mir, Daniel Hoyer
The discovery of the orexin system represents the single major progress in the sleep field of the last three to four decades. The two orexin peptides and their two receptors play a major role in arousal and sleep/wake cycles. Defects in the orexin system lead to narcolepsy with cataplexy in humans and dogs and can be experimentally reproduced in rodents. At least six orexin receptor antagonists have reached Phase II or Phase III clinical trials in insomnia, five of which are dual orexin receptor antagonists (DORAs) that target both OX1 and OX2 receptors (OX2Rs)...
December 2, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27907210/assessing-potentially-inappropriate-prescribing-in-community-dwelling-older-patients-using-the-updated-version-of-stopp-start-criteria-a-comparison-of-profiles-and-prevalences-with-respect-to-the-original-version
#3
Encarnación Blanco-Reina, Maria Rosa García-Merino, Ricardo Ocaña-Riola, Lorena Aguilar-Cano, Jennifer Valdellós, Inmaculada Bellido-Estévez, Gabriel Ariza-Zafra
Emerging and changing evidence made it necessary to update STOPP-START criteria, and version 2 was published recently. In this study the objectives were to determine the prevalence of potentially inappropriate medication prescribing (PIM) in primary care using STOPP versions 1 (v1) and 2 (v2), as well as 2012 AGS Beers criteria, and analyze the factors associated with inappropriate prescribing according to STOPP/START v2. A cross-sectional study was carried out including community-dwelling older adults over the age of 65...
2016: PloS One
https://www.readbyqxmd.com/read/27902836/effect-of-a-web-based-cognitive-behavior-therapy-for-insomnia-intervention-with-1-year-follow-up-a-randomized-clinical-trial
#4
Lee M Ritterband, Frances P Thorndike, Karen S Ingersoll, Holly R Lord, Linda Gonder-Frederick, Christina Frederick, Mark S Quigg, Wendy F Cohn, Charles M Morin
Importance: Although cognitive behavior therapy for insomnia (CBT-I) has been established as the first-line recommendation for the millions of adults with chronic insomnia, there is a paucity of trained clinicians to deliver this much needed treatment. Internet-delivered CBT-I has shown promise as a method to overcome this obstacle; however, the long-term effectiveness has not been proven in a representative sample with chronic insomnia. Objective: To evaluate a web-based, automated CBT-I intervention to improve insomnia in the short term (9 weeks) and long term (1 year)...
November 30, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27902827/should-internet-cognitive-behavioral-therapy-for-insomnia-be-the-primary-treatment-option-for-insomnia-toward-getting-more-shuti
#5
Andrew D Krystal, Aric A Prather
No abstract text is available yet for this article.
November 30, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27895576/sleep-disturbances-among-older-adults-in-the-united-states-2002-2012-nationwide-inpatient-rates-predictors-and-outcomes
#6
Alyssa A Gamaldo, May A Beydoun, Hind A Beydoun, Hailun Liang, Rachel E Salas, Alan B Zonderman, Charlene E Gamaldo, Shaker M Eid
Objective/Background: We examined the rates, predictors, and outcomes [mortality risk (MR), length of stay (LOS), and total charges (TC)] of sleep disturbances in older hospitalized patients. Patients/Methods: Using the U.S. Nationwide Inpatient Sample database (2002-2012), older patients (≥60 years) were selected and rates of insomnia, obstructive sleep apnea (OSA) and other sleep disturbances (OSD) were estimated using ICD-9CM. TC, adjusted for inflation, was of primary interest, while MR and LOS were secondary outcomes...
2016: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/27888416/lesion-remyelinating-activity-of-gsk239512-versus-placebo-in-patients-with-relapsing-remitting-multiple-sclerosis-a-randomised-single-blind-phase-ii-study
#7
Caryl J Schwartzbach, Richard A Grove, Robert Brown, Debra Tompson, Florian Then Bergh, Douglas L Arnold
Histamine H3 receptor blockade may enhance lesion remyelination in multiple sclerosis (MS). The efficacy (using a magnetic resonance imaging marker of myelination, magnetisation transfer ratio [MTR]), safety and pharmacokinetics of GSK239512, a potent and brain penetrant H3 receptor antagonist/inverse agonist on lesion remyelination in relapsing-remitting MS (RRMS) were assessed. This was a phase II, randomised, parallel-group, placebo-controlled, double-blind (sponsor-unblinded), international, multicentre study (NCT01772199)...
November 25, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27867101/regulation-of-fear-extinction-by-long-term-depression-the-roles-of-endocannabinoids-and-brain-derived-neurotrophic-factor
#8
REVIEW
Maxwell R Bennett, Jonathon Arnold, Sean N Hatton, Jim Lagopoulos
The extinction of a conditioned fear response is of great interest in the search for a means of ameliorating adverse neurobiological changes resulting from stress. The discovery that endocannibinoid (EC) levels are inversely related to the extent of such stress, and that the amygdala is a primary site mediating stress, suggests that ECs in this brain region might play a major role in extinction. Supporting this are the observations that the basolateral complex of the amygdala shows an increase in ECs only during extinction and that early clinical trials indicate that cannabinoid-like agents, when taken orally by patients suffering from post traumatic stress disorder (PTSD), reduce insomnia and nightmares...
November 17, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27864356/the-social-gradient-of-sleep-in-adolescence-results-from-the-youth-hordaland-survey
#9
Mari Hysing, Keith J Petrie, Tormod Bøe, Tea Lallukka, Børge Sivertsen
BACKGROUND: A social gradient of sleep problems has been demonstrated in both children and adults, but our knowledge about possible social determinants of adolescent sleep problems remains limited. METHODS: A large population-based study in Norway surveyed 10 220 adolescents aged 16-19 years in 2012. Multiple socioeconomic status (SES) indicators and assessment of sleep, including DSM-5 insomnia, sleep duration, weekend-weekdays differences, as well as sleep deficit and delayed sleep phase were included...
November 17, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/27852282/effect-of-acupuncture-on-insomnia-following-stroke-study-protocol-for-a-randomized-controlled-trial
#10
Yan Cao, Xuan Yin, Francisca Soto-Aguilar, Yiping Liu, Ping Yin, Junyi Wu, Bochang Zhu, Wentao Li, Lixing Lao, Shifen Xu
BACKGROUND: The incidence, mortality, and prevalence of stroke are high in China. Stroke is commonly associated with insomnia; both insomnia and stroke have been effectively treated with acupuncture for a long time. The aim of this proposed trial is to assess the therapeutic effect of acupuncture on insomnia following stroke. METHODS: This proposed study is a single-center, single-blinded (patient-assessor-blinded), parallel-group randomized controlled trial. We will randomly assign 60 participants with insomnia following stroke into two groups in a 1:1 ratio...
November 16, 2016: Trials
https://www.readbyqxmd.com/read/27851868/pharmacotherapies-for-sleep-disturbances-in-dementia
#11
REVIEW
Jenny McCleery, Daniel A Cohen, Ann L Sharpley
BACKGROUND: Sleep disturbances, including reduced nocturnal sleep time, sleep fragmentation, nocturnal wandering, and daytime sleepiness are common clinical problems in dementia, and are associated with significant caregiver distress, increased healthcare costs, and institutionalisation. Drug treatment is often sought to alleviate these problems, but there is significant uncertainty about the efficacy and adverse effects of the various hypnotic drugs in this vulnerable population. OBJECTIVES: To assess the effects, including common adverse effects, of any drug treatment versus placebo for sleep disorders in people with dementia, through identification and analysis of all relevant randomised controlled trials (RCTs)...
November 16, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27829954/the-effects-of-ramelteon-on-glucose-metabolism-and-sleep-quality-in-type-2-diabetic-patients-with-insomnia-a-pilot-prospective-randomized-controlled-trial
#12
Tetsuji Tsunoda, Masayo Yamada, Tomoaki Akiyama, Taichi Minami, Taishi Yoshii, Yoshinobu Kondo, Shinobu Satoh, Yasuo Terauchi
BACKGROUND: Insomnia is associated with the onset and development of diabetes. Melatonin affects sleep quality and glucose metabolism in diabetic patients with insomnia. We administered ramelteon, an agonist of melatonin, to type 2 diabetic patients and investigated its effects on glucose metabolism and insomnia. METHODS: This multicenter, prospective, randomized, and observational pilot study was performed between April 2014 and April 2015 at three institutes in Japan...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27825412/restless-legs-syndrome-in-adults-in-peking-union-medical-college-hospital
#13
Jian-Hua Chen, Rong Huang, Jin-Mei Luo, Yi Xiao, Xu Zhong, Xiu-Qin Liu
Objective To investigate the clinical characteristics of restless legs syndrome (RLS) in adults in Peking Union Medical College Hospital and explore the sleep quality,fatigue degree,daytime sleepiness,disease severity,depression and anxiety of RLS patients.Methods Totally 4739 consecutive patients who visited the outpatient departments with any sleep complaint or leg discomforts were recruited in the study. Patients under 18 years were excluded. All participants answered RLS questionnaire. The subjects fulfilled all four criteria would be followed up and given advanced examinations to rule out secondary RLS and RLS mimics...
October 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27821210/asenapine-for-the-treatment-of-adults-with-an-acute-exacerbation-of-schizophrenia-results-from-a-randomized-double-blind-fixed-dose-placebo-controlled-trial-with-olanzapine-as-an-active-control
#14
Ronald Landbloom, Mary Mackle, Xiao Wu, Linda Kelly, Linda Snow-Adami, Roger S McIntyre, Maju Mathews, Carla Hundt
OBJECTIVE: Evaluate the efficacy and safety of asenapine 2.5 mg twice daily (bid; n=97) or 5 mg bid (n=113) versus placebo (n=101) in adults with acute exacerbation of schizophrenia. METHODS: Adults with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) schizophrenia diagnosis were randomized to asenapine 2.5 mg bid, 5 mg bid, placebo, or olanzapine 15 mg once daily. The primary objective was to test superiority of asenapine versus placebo as measured by the change from baseline to day 42 in the Positive and Negative Syndrome Scale (PANSS) total score...
November 8, 2016: CNS Spectrums
https://www.readbyqxmd.com/read/27814838/benzodiazepine-use-in-older-adults-dangers-management-and-alternative-therapies
#15
REVIEW
Matej Markota, Teresa A Rummans, John Michael Bostwick, Maria I Lapid
Several major medical and psychiatric organizations, including the American Geriatrics Society, advise against using benzodiazepines or nonbenzodiazepine hypnotics in older adults. Despite these recommendations, benzodiazepines continue to be massively prescribed to a group with the highest risk of serious adverse effects from these medications. This article summarizes legitimate reasons for prescribing benzodiazepines in the elderly, serious associated risks of prescribing them, particularly when not indicated, barriers physicians encounter in changing their prescription patterns, and evidence-based strategies on how to discontinue benzodiazepines in older patients...
November 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27810669/modafinil-for-the-treatment-of-attention-deficit-hyperactivity-disorder-a-meta-analysis
#16
Sheng-Min Wang, Changsu Han, Soo-Jung Lee, Tae-Youn Jun, Ashwin A Patkar, Prakash S Masand, Chi-Un Pae
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common and a debilitating neuro-behavior disorder in the pediatric population. Although numerous effective psychostimulants are available, more than 30% of patients still do not show adequate treatment response rendering diverse pharmacological options. We aimed at assessing the efficacy and safety of modafinil in the treatment of children and adolescents with ADHD by conducting a meta-analysis. An extensive search of databases and clinical trial registries resulted in five published short-term randomized, double-blind, placebo-controlled trials...
January 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27810178/deficits-in-attention-performance-are-associated-with-insufficiency-of-slow-wave-sleep-in-insomnia
#17
Yun Li, Hong Liu, Jason G Weed, Rong Ren, Yuanfeng Sun, Lu Tan, Xiangdong Tang
OBJECTIVE: Cognitive impairment is associated with insomnia. However, there is a lack of evidence suggesting a link between insomnia and cognitive dysfunction in objective testing. The objectives of our current study were to assess the differences in components of attentional performance between primary insomnia patients and normal-sleeping controls and to examine potential predictors of attention impairment in patients with insomnia. METHODS: We studied 36 patients (age 40...
August 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27806499/personality-development-since-childhood-associated-with-adult-chronic-insomnia-a-study-by-wang-s-memory-tracing-personality-development-inventory-wmpi
#18
Xueyu Lv, Yan Ma, Fan Feng, Lan Hong, Jian Wang, Weidong Wang
OBJECTIVE: This study aimed to analyze the deviation in normal personality development in chronic insomnia patients. MATERIAL & METHODS: Eighty-one patients with chronic insomnia and 290 healthy controls were assessed with Wang's Memory Tracing Personality Development Inventory (WMPI). Differences between the two groups were explored to identify developmental characteristics. RESULTS: Significant differences were found in three phases. During the chronological ages of 3-6 years old, the differences are relatively minor, and manifest in a lower independence level in patients (p<0...
July 12, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27804222/descriptive-analysis-of-pro-re-nata-medication-use-at-a-canadian-psychiatric-hospital
#19
Krystle Martin, Vinita Arora, Ilan Fischler, Renee Tremblay
Pro re nata (PRN), a Latin phrase meaning 'as needed', is used to describe medications that might be used in specific situations, in addition to regularly-scheduled medications, such as when a patient is particularly anxious, experiencing insomnia, or suffering pain. While helpful in some circumstances, PRN are associated with an increased risk of morbidity, overuse, dependence, and polypharmacy. There is also a dearth of medical literature describing current practices and trends of PRN administration in mental health facilities, especially in Canada, and the literature that does exist is limited by poor documentation practices...
November 2, 2016: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/27793197/self-administered-acupressure-for-symptom-management-among-chinese-family-caregivers-with-caregiver-stress-a-randomized-wait-list-controlled-trial
#20
Agnes Tiwari, Lixing Lao, Amy Xiao-Min Wang, Denise Shuk Ting Cheung, Mike Ka Pui So, Doris Sau Fung Yu, Terry Yat Sang Lum, Helina Yin King Yuk Fung, Jerry Wing Fai Yeung, Zhang-Jin Zhang
BACKGROUND: Caregiving can be stressful, potentially creating physical and psychological strain. Substantial evidence has shown that family caregivers suffer from significant health problems arising from the demands of caregiving. Although there are programs supporting caregivers, there is little evidence regarding their effectiveness. Acupressure is an ancient Chinese healing method designed to restore the flow of Qi (vital energy) by applying external pressure to acupoints. A randomized, wait-list controlled trial was developed to evaluate the effectiveness of a self-administered acupressure intervention on caregiver stress (primary objective) and stress-related symptoms of fatigue, insomnia, depression, and health-related quality of life (secondary objectives) in Chinese caregivers of older family members...
October 28, 2016: BMC Complementary and Alternative Medicine
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