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https://www.readbyqxmd.com/read/28431551/guided-internet-based-versus-face-to-face-clinical-care-in-the-management-of-tinnitus-study-protocol-for-a-multi-centre-randomised-controlled-trial
#1
Eldré W Beukes, David M Baguley, Peter M Allen, Vinaya Manchaiah, Gerhard Andersson
BACKGROUND: Innovative strategies are required to improve access to evidence-based tinnitus interventions. A guided Internet-based cognitive behavioural therapy (iCBT) intervention for tinnitus was therefore developed for a U.K. POPULATION: Initial clinical trials indicated efficacy of iCBT at reducing tinnitus severity and associated comorbidities such as insomnia and depression. The aim of this phase III randomised controlled trial is to compare this new iCBT intervention with an established intervention, namely face-to-face clinical care for tinnitus...
April 21, 2017: Trials
https://www.readbyqxmd.com/read/28421536/lysosomal-quality-control-in-prion-diseases
#2
REVIEW
Priyanka Majumder, Oishee Chakrabarti
Prion diseases are transmissible, familial or sporadic. The prion protein (PrP), a normal cell surface glycoprotein, is ubiquitously expressed throughout the body. While loss of function of PrP does not elicit apparent phenotypes, generation of misfolded forms of the protein or its aberrant metabolic isoforms has been implicated in a number of neurodegenerative disorders such as scrapie, kuru, Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Sträussler-Scheinker and bovine spongiform encephalopathy...
April 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28417334/sleep-quality-duration-and-breast-cancer-aggressiveness
#3
Allison Soucise, Caila Vaughn, Cheryl L Thompson, Amy E Millen, Jo L Freudenheim, Jean Wactawski-Wende, Amanda I Phipps, Lauren Hale, Lihong Qi, Heather M Ochs-Balcom
PURPOSE: Epidemiological studies suggest that short sleep duration and poor sleep quality may increase breast cancer risk. However, whether sleep is associated with breast tumor aggressiveness characteristics has largely been unexplored. METHODS: The study included 4171 non-Hispanic whites (NHW) and 235 African Americans (AA) diagnosed with incident, primary, invasive breast cancer in the Women's Health Initiative (WHI) Observational Study (1994-2013). We used logistic regression to examine the association of baseline sleep (sleep duration, sleep quality, WHI Insomnia Rating Scale) with tumor grade, stage, hormone receptor status, HER2 status...
April 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28413925/triple-bead-mixed-amphetamine-salts-shp465-in-adults-with-adhd-results-of-a-phase-3-double-blind-randomized-forced-dose-trial
#4
Glen Frick, Brian Yan, Lenard A Adler
OBJECTIVE: Evaluate the efficacy and tolerability of triple-bead mixed amphetamine salts (MAS) in ADHD. METHOD: Adults with ADHD Rating Scale IV (ADHD-RS-IV) total scores ≥32 were randomized to 6 weeks of triple-bead MAS (25, 50, or 75 mg) or placebo. The primary endpoint was ADHD-RS-IV total score change from baseline at end of study (EOS). RESULTS: Least squares mean (95% confidence interval [CI]) treatment differences for ADHD-RS-IV total score changes from baseline to EOS significantly favored triple-bead MAS (all doses combined: -10...
April 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28403895/electroacupuncture-for-insomnia-disorder-study-protocol-for-a-randomized-controlled-trial
#5
Sung-Phil Kim, Joo-Hee Kim, Bo-Kyung Kim, Hyeong-Jun Kim, In Chul Jung, Jung Hyo Cho, Jung-Eun Kim, Mi-Kyung Kim, O-Jin Kwon, Ae-Ran Kim, Hyo-Ju Park, Bok-Nam Seo
BACKGROUND: Insomnia is a common sleep disorder that affects many adults either transiently or chronically. The societal cost of insomnia is on the rise, while long-term use of current drug treatments can involve adverse effects. Recently, electroacupuncture (EA) has been used to treat various conditions including insomnia. The objective of this study is to provide scientific evidence for the effect and safety of using EA to treat insomnia. METHODS/DESIGN: In this multicentre, assessor-blind, three-arm, parallel-design, randomised controlled trial, 150 participants will be assigned to the EA group, the sham EA (SEA) group, or the usual care group...
April 13, 2017: Trials
https://www.readbyqxmd.com/read/28400355/mobile-phone-delivered-cognitive-behavioral-therapy-for-insomnia-a-randomized-waitlist-controlled-trial
#6
Corine Hg Horsch, Jaap Lancee, Fiemke Griffioen-Both, Sandor Spruit, Siska Fitrianie, Mark A Neerincx, Robbert Jan Beun, Willem-Paul Brinkman
BACKGROUND: This study is one of the first randomized controlled trials investigating cognitive behavioral therapy for insomnia (CBT-I) delivered by a fully automated mobile phone app. Such an app can potentially increase the accessibility of insomnia treatment for the 10% of people who have insomnia. OBJECTIVE: The objective of our study was to investigate the efficacy of CBT-I delivered via the Sleepcare mobile phone app, compared with a waitlist control group, in a randomized controlled trial...
April 11, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28400181/cognitive-behavior-therapy-to-treat-sleep-disturbance-and-fatigue-following-traumatic-brain-injury-a-pilot-randomized-controlled-trial
#7
Sylvia Nguyen, Adam McKay, Dana Wong, S M Rajaratnam, Gershon Spitz, Gavin Williams, Darren Mansfield, Jennie L Ponsford
OBJECTIVE: To evaluate the efficacy of adapted cognitive behavioral therapy (CBT) for sleep disturbance and fatigue in individuals with traumatic brain injury (TBI). DESIGN: Parallel two-group randomized controlled trial. SETTING: Outpatient therapy in the Melbourne metropolitan area. PARTICIPANTS: Twenty-four adults with history of TBI and clinically significant sleep and/or fatigue complaints were randomly allocated to an eight-session adapted CBT intervention or a treatment as usual (TAU) condition...
April 8, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28399441/sleep-architecture-in-insomniacs-with-severe-benzodiazepine-abuse
#8
Mauro Manconi, Raffaele Ferri, Silvia Miano, Michelangelo Maestri, Valentina Bottasini, Marco Zucconi, Luigi Ferini-Strambi
OBJECTIVE: Benzodiazepines (BZDs) are the most commonly prescribed compounds in insomnia. A long-term of BZDs use may cause dependence and abuse. The aim of this study was to evaluate sleep architecture and microstructure (in terms of cyclic alternating pattern - CAP - analysis and of sleep EEG power spectral analysis) in a group of long-term users of high doses of BZDs for their primary chronic insomnia. METHODS: Twenty patients consecutively admitted at the Sleep Centre for drug discontinuation and 13 matched healthy controls underwent a full nocturnal video-polysomnographic recording, after one adaptation night...
March 16, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28395207/brief-cognitive-behavioral-therapy-for-insomnia-delivered-to-depressed-veterans-receiving-primary-care-services-a-pilot-study
#9
Wilfred R Pigeon, Jennifer Funderburk, Todd M Bishop, Hugh F Crean
BACKGROUND: Depression and insomnia are treatable, often co-occur and are common among primary care patients. Treatments designed for primary care must be brief, effective and ideally have the potential to address multiple symptoms. A brief form of cognitive behavioral therapy for insomnia (CBT-I) was piloted among depressed primary care patients with insomnia some of whom endorsed suicidal ideation. METHODS: Veterans Affairs primary care patients were randomized to either CBT-I or sleep hygiene...
April 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28391289/sleep-to-lower-elevated-blood-pressure-a-randomized-controlled-trial-slept
#10
Emer R McGrath, Colin A Espie, Alice Power, Andrew W Murphy, John Newell, Caroline Kelly, Niamh Duffy, Patricia Gunning, Irene Gibson, Sophie Bostock, Martin J O'Donnell
BACKGROUND: Impaired sleep quality is common and associated with an increased risk of cardiovascular disease (CVD), thought to be mediated through adverse effects on established vascular risk factors, particularly hypertension. We determined if a web-delivered sleep intervention (sleep-hygiene education, stimulus control, and cognitive behavioral therapy) reduces blood pressure compared to vascular risk factor education (standard care) alone. METHODS: Phase II randomized, blinded, controlled trial of 134 participants without CVD with mild sleep impairment and blood pressure 130-160/<110 mm Hg...
March 1, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28377394/efficacy-and-safety-of-suanzaoren-decoction-for-chronic-insomnia-disorder-in-adults-study-protocol-for-randomised-double-blind-double-dummy-placebo-controlled-trial
#11
Qi-Hui Zhou, Hui-Lin Wang, Xiao-Li Zhou, Meng-Bei Xu, Hong-Feng Zhang, Li-Bo Huang, Guo-Qing Zheng, Yan Lin
BACKGROUND: Insomnia disorder is defined as a combination of dissatisfaction with sleep quantity or quality and a significant negative impact on daytime functioning. Chronic insomnia disorder refers to clinical symptoms of persistent insomnia at least three nights a week for at least 3 months. Prevalence estimates of insomnia disorder range from 12% to 20% in the adult population, with approximately 50% having a chronic course. The potential side effects of hypnotic medications hinder their clinical application...
April 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28377393/does-a-brief-behavioural-intervention-delivered-by-paediatricians-or-psychologists-improve-sleep-problems-for-children-with-adhd-protocol-for-a-cluster-randomised-translational-trial
#12
E Sciberras, M Mulraney, H Heussler, N Rinehart, T Schuster, L Gold, N Hayes, H Hiscock
INTRODUCTION: Up to 70% of children with attention-deficit/hyperactivity disorder (ADHD) experience sleep problems. We have demonstrated the efficacy of a brief behavioural intervention for children with ADHD in a large randomised controlled trial (RCT) and now aim to examine whether this intervention is effective in real-life clinical settings when delivered by paediatricians or psychologists. We will also assess the cost-effectiveness of the intervention. METHODS AND ANALYSIS: Children aged 5-12 years with ADHD (n=320) are being recruited for this translational cluster RCT through paediatrician practices in Victoria and Queensland, Australia...
April 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/28367712/the-clinical-characteristics-of-adhd-diagnosed-in-adolescents-in-comparison-with-younger-children
#13
Muhammad Mahajnah, Rajech Sharkia, Nadeem Shorbaji, Nathanel Zelnik
OBJECTIVE: The aim of this study is to identify the clinical characteristics in adolescents newly diagnosed with ADHD. METHOD: Data of patients aged 7 to 17 years diagnosed with ADHD were collected and analyzed. The patients were divided into adolescents aged 13 to 17 years (Group I) and children aged 7 to 12 years (Group II): 592 males and 231 females. Group I consists of 450 participants, and Group II consists of 373 participants. RESULTS: Adolescents were predominantly inattentive (63...
March 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28365447/suvorexant-for-the-treatment-of-primary-insomnia-a-systematic-review-and-meta-analysis
#14
REVIEW
Akira Kuriyama, Hiromitsu Tabata
Suvorexant is a dual orexin receptor agonist and is currently approved for the treatment of insomnia in the United States and Japan. We conducted a systematic review and meta-analysis to assess the efficacy and safety of suvorexant for the treatment of primary insomnia. We searched PubMed, EMBASE, and the Cochrane central register of controlled trials, contacted a relevant pharmaceutical company, and accessed websites of the U.S. Food and Drug Administration (FDA) and Pharmaceuticals and Medical Devices Agency (PMDA) for published and unpublished data...
October 28, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28365203/the-bidirectional-longitudinal-relationship-between-insomnia-depression-and-anxiety-in-patients-with-early-stage-medication-na%C3%A3-ve-parkinson-s-disease
#15
Sonja Rutten, Chris Vriend, Ysbrand D van der Werf, Henk W Berendse, Daniel Weintraub, Odile A van den Heuvel
INTRODUCTION: While anxiety, depression and insomnia frequently (co-)occur in Parkinson's disease (PD) patients, little is known about their temporal relationship. In this study, we tested two hypotheses: i) insomnia predicts an increase in symptoms of depression or anxiety and ii) anxiety or depression at baseline predicts insomnia in PD patients six months later. METHODS: We used longitudinal data from a prospective cohort study of early-stage, medication-naïve PD patients...
February 1, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28364590/hyperarousal-during-sleep-in-untreated-primary-insomnia-sufferers-a-polysomnographic-study
#16
Matthieu Hein, Christelle Senterre, Jean-Pol Lanquart, Xavier Montana, Gwénolé Loas, Paul Linkowski, Philippe Hubain
Because some evidence favors the hyperarousal model of insomnia, we sought to learn more about the dynamics of this phenomenon during sleep. Polysomnographic data from 30 normative subjects and 86 untreated primary insomnia sufferers recruited from the database of the sleep laboratory were studied for whole nights and in terms of thirds of the night. Untreated primary insomnia sufferers had an increased sleep latency and excess of WASO, together with a deficit in REM and NREM sleep during the entire night. In terms of thirds of the night, they presented a major excess of WASO during the first and last thirds of the night but an excess of lesser importance during the middle third...
March 23, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28364509/dual-orexin-receptor-antagonist-almorexant-in-elderly-patients-with-primary-insomnia-a-randomized-controlled-study
#17
Thomas Roth, Jed Black, Raymond Cluydts, Pascal Charef, Marzia Cavallaro, Fabrice Kramer, Gary Zammit, James Walsh
Objective: Sleep laboratory study to determine the dose-related efficacy and safety of almorexant in elderly patients with primary chronic insomnia. Methods: Patients aged ≥65 years with primary insomnia were enrolled into a prospective, randomized, double-blind, placebo-controlled, multicenter dose-finding study with a five-period, five-way Latin square cross-over design. Patients were randomized to one of 10 unique sequences of two-night treatment with oral almorexant 25, 50, 100, or 200 mg capsules, or matching placebo...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28359309/electroacupuncture-for-tapering-off-long-term-benzodiazepine-use-study-protocol-of-randomized-controlled-trial
#18
RANDOMIZED CONTROLLED TRIAL
Wing-Fai Yeung, Ka-Fai Chung, Zhang-Jin Zhang, Wai-Chi Chan, Shi-Ping Zhang, Roger Man-Kin Ng, Connie Lai-Wah Chan, Lai-Ming Ho, Yee-Man Yu, Li-Xing Lao
BACKGROUND: Conventional approaches for benzodiazepine tapering have their limitations. Anecdotal studies have shown that acupuncture is a potential treatment for facilitating successful benzodiazepine tapering. As of today, there was no randomized controlled trial examining its efficacy and safety. The purpose of the study is to evaluate the efficacy of using electroacupuncture as an adjunct treatment to gradual tapering of benzodiazepine doses in complete benzodiazepine cessation in long-term benzodiazepine users...
March 31, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28348990/prevalence-of-chronic-insomnia-in-adult-patients-and-its-correlation-with-medical-comorbidities
#19
Swapna Bhaskar, D Hemavathy, Shankar Prasad
INTRODUCTION: Insomnia is one of the common but neglected conditions seen in family practice with long term and serious effects on health of a patient. Family physicians have the responsibility of diagnosing and adequately treating this. This study was done to find the prevalence of chronic insomnia in adult patients visiting a family medicine outpatient department (OPD) in a hospital and to assess the risk factors and co morbidities associated with it. MATERIALS AND METHODS: A cross-sectional study was done in the family medicine OPD at St...
October 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28345961/the-short-term-efficacy-of-an-unguided-internet-based-cognitive-behavioral-therapy-for-insomnia-a-randomized-controlled-trial-with-a-six-month-nonrandomized-follow-up
#20
Susanne Hagatun, Øystein Vedaa, Tine Nordgreen, Otto R F Smith, Ståle Pallesen, Odd E Havik, Bjørn Bjorvatn, Frances P Thorndike, Lee M Ritterband, Børge Sivertsen
OBJECTIVE: Insomnia is a major health problem, and the need for effective and accessible treatment is urgent. The aim of the current study was to evaluate the short-term efficacy of an unguided Internet-based cognitive-behavioral treatment program for insomnia (CBTi), called SHUTi (Sleep Healthy Using the Internet). METHODS: This study used a parallel arm randomized controlled trial in Norway. Participants were randomly allocated to the SHUTi condition or a Web-based patient education condition...
March 27, 2017: Behavioral Sleep Medicine
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