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Thyroid elderly

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https://www.readbyqxmd.com/read/29142852/thyroidectomy-in-elderly-patients-aged-%C3%A2-70-years
#1
REVIEW
Davide Inversini, Andrea Morlacchi, Giuseppinella Melita, Simona Del Ferraro, Carlo Boeri, Mattia Portinari, Antonino Cancellieri, Francesco Frattini, Antonio Giacomo Rizzo, Gianlorenzo Dionigi
Worldwide, the indications for thyroid surgery have been continuously extended among elderly patients in the last 20 years. The balance between treatment indication and surgical risk is certainly an interesting topic for every thyroid surgeon. This paper is a review of recent literature from January 2005 up to April 2017. We analyzed three principal subjects: indications for surgical treatment, medical complications and surgical complications. We can summarize the conclusions of our analysis, stating that age could not be considered as an absolute factor, but in relation to the comorbidities and the general clinical condition of the patient...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29131274/expression-level-and-clinical-significance-of-il-2-il-6-and-tgf-%C3%AE-in-elderly-patients-with-goiter-and-hyperthyroidism
#2
L-F Lv, H-Y Jia, H-F Zhang, Y-X Hu
OBJECTIVE: To investigate the level of expression and the clinical significance of IL-2 (interleukin-2), IL-6 (interleukin-6) and TGF-β (transforming growth factor-β) in elderly patients with goiter and hyperthyroidism. PATIENTS AND METHODS: Gender, age, course of disease, BMI (Body Mass Index), serum FT3 (Free triiodothyronine-3), FT4 (Free triiodothyronine-4), TT3 (Total triiodothyronine-3), TT4 (Total triiodothyronine-4), TSH (Thyroid Stimulating Hormone) and clinical manifestations on admission and other general clinical data and laboratory examination results were collected and statistically analyzed as case group in 128 elderly patients with goiter and hyperthyroidism...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29124061/diagnostics-of-thyroid-malignancy-and-indications-for-surgery-in-the-elderly-and-younger-counterparts-comparison-of-3-749-patients
#3
Krzysztof Kaliszewski, Dorota Diakowska, Marta Strutyńska-Karpińska, Beata Wojtczak, Michał Aporowicz, Zdzisław Forkasiewicz, Waldemar Balcerzak, Tadeusz Łukieńczuk, Paweł Domosławski
Background: It seems valuable for clinicians to know if diagnostics of thyroid malignancy (TM) and indications for surgery in the elderly patients differ from these in younger counterparts. Materials and Methods: Retrospective analysis of the medical records of 3,749 patients surgically treated for thyroid tumor. Data of patients with histopathology confirmed TM (n = 309) were studied. Results: The rate of cytological prediction to malignancy was more than three times higher in elderly women...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29121039/the-prevalence-and-determinants-of-multimorbidity-in-hospitalized-patients-with-heart-failure
#4
Olga Siga, Barbara Wizner, Karolina Piotrowicz, Małgorzata Fedyk-Łukasik, Tomasz Grodzicki
OBJECTIVE: The aim of this study was to assess the prevalence of multimorbidity and co-existed diseases in hospitalized patients with heart failure (HF) in relation to age and gender. METHODS: The nationwide cross-sectional survey had been conducted in Poland (April-November 2013), in 260 randomly selected hospital wards. A trained nurse contacted with one physician, drawn from the list of all doctors working in the selected hospital's wards, who completed the study questionnaires regarding to clinical characteristics of the last five HF patients, who were discharged from an internal or cardiology ward...
2017: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/29105624/effects-of-thyroid-hormone-replacement-therapy-on-thyroid-hormone-levels-and-electrocardiogram-changes-in-geriatric-patients-with-hypothyroidism
#5
Xianghong Zhai
This paper aims to analyze the effects of thyroid hormone replacement therapy on thyroid hormone levels and electrocardiogram changes in elderly patients with hypothyroidism. 48 elderly patients with hypothyroidism admitted to our hospital from January 2014 to December 2014 were selected as subjects. All the patients were treated with thyroid hormone replacement therapy. The changes of thyroid hormone levels and ECG parameters were compared before and after treatment. After treatment, serum thyroid stimulating hormone (TSH) was significantly lower than that before treatment, and the free triiodothyronine (FT3) and free thyroxine (FT4) were significantly higher than those before treatment (t=15...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29089349/thyroid-function-and-the-risk-of-atherosclerotic-cardiovascular-morbidity-and-mortality-the-rotterdam-study
#6
Arjola Bano, Layal Chaker, Francesco U Mattace-Raso, Aad van der Lugt, M Arfan Ikram, Oscar H Franco, Robin P Peeters, Maryam Kavousi
Rationale: Thyroid hormones have been linked with various proatherogenic and antiatherogenic processes. However, the relationship of thyroid function with manifestations of atherosclerosis remains unclear. Objective: To investigate the association of thyroid function with atherosclerosis throughout its spectrum; i.e. subclinical atherosclerosis, incident atherosclerotic cardiovascular (ASCV) events and ASCV mortality. Methods and Results: This population-based study was embedded within the Rotterdam Study. The risk of atherosclerosis was evaluated by measuring: 1...
October 31, 2017: Circulation Research
https://www.readbyqxmd.com/read/29070621/fatal-outcome-of-an-anaplastic-thyroid-tumour
#7
Rafael García Carretero, Cristina Peña-Arce, Gabriel Martinez-Quesada, Javier Garcia-Alvarez
Anaplastic thyroid cancer is a rare form of thyroid cancer, known for its very poor prognosis, even with the appropriate management. It is very aggressive, with a tendency to invade locally and lymph node metastasis is often present at the time of diagnosis. We present an elderly patient, who presented with rapid enlarging neck mass, which, within weeks, led to his death. His family gave their consent to perform an autopsy, and here we describe and illustrate the profound aggressiveness of this tumour.
October 25, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29056955/comparison-of-long-term-outcome-between-patients-aged-65-years-vs-%C3%A2-65-years-after-atrial-fibrillation-ablation
#8
Zsuzsanna Kis, Anna Me Noten, Mihran Martirosyan, Astrid A Hendriks, Rohit Bhagwandien, Tamas Szili-Torok
BACKGROUND: Atrial fibrillation (AF) is the most frequent arrhythmia, and its prevalence is increasing with aging. We aimed to compare the long-term outcome data of patients < 65 years vs. ≥ 65 years who underwent catheter ablation (CA) for drug-refractory AF. METHODS: Consecutive patients with primary pulmonary vein isolation performed between March 2001 and December 2011, and those who completed a five-year of follow-up were divided into two groups: patients aged < 65 years into group 1, and patients aged ≥ 65 into group 2...
September 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29031027/evaluation-of-renal-perfusion-in-hyperthyroid-cats-before-and-after-radioiodine-treatment
#9
E Stock, S Daminet, D Paepe, E Buresova, E Vandermeulen, P Smets, L Duchateau, J H Saunders, K Vanderperren
BACKGROUND: Hyperthyroidism and chronic kidney disease (CKD) are common in elderly cats. Consequently, both diseases often occur concurrently. Furthermore, renal function is affected by thyroid status. Because changes in renal perfusion play an important role in functional renal changes in hyperthyroid cats, investigation of renal perfusion may provide novel insights. OBJECTIVES: To evaluate renal perfusion in hyperthyroid cats with contrast-enhanced ultrasound (CEUS)...
October 14, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29020715/diagnosis-and-management-of-polymyalgia-rheumatica
#10
REVIEW
Olwyn Jones, Fraser Birrell
Polymyalgia rheumatica (PMR) is a common inflammatory condition of unknown aetiology with a prevalence of 1 in 133 in the over 50s, and a female to male ratio of 2:1. Symptoms develop over a matter of weeks; typically bilateral shoulder or pelvic girdle pain and stiffness, that is worse in the mornings. Associated symptoms include low-grade fever, malaise, fatigue, low mood, poor appetite, and weight loss. There is no specific diagnostic test for PMR but the usual pattern is a commensurate rise in CRP and ESR...
December 2016: Practitioner
https://www.readbyqxmd.com/read/28967725/testicular-and-thyroid-function-as-survival-predictors-in-the-elderly-patient-candidate-to-surgery
#11
Antonio Aversa, Andrea Fabbri
The relationship between testosterone deficiency (TD) syndrome and surgical resilience has a great impact in the modern approach to male elderly patients. There is good evidence that low levels of T are a strong marker for cardiovascular risk; also, TD is frequently associated with increased cardiovascular and all-cause mortality especially in cardiac older frail men. Screening for low T should be mandatory in high risk groups candidate to surgery including those with diabetes, metabolic syndrome and obesity, even though benefits from T-treatment on survival rates are unclear...
July 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28967485/first-line-pembrolizumab-in-cisplatin-ineligible-patients-with-locally-advanced-and-unresectable-or-metastatic-urothelial-cancer-keynote-052-a-multicentre-single-arm-phase-2-study
#12
Arjun V Balar, Daniel Castellano, Peter H O'Donnell, Petros Grivas, Jacqueline Vuky, Thomas Powles, Elizabeth R Plimack, Noah M Hahn, Ronald de Wit, Lei Pang, Mary J Savage, Rodolfo F Perini, Stephen M Keefe, Dean Bajorin, Joaquim Bellmunt
BACKGROUND: More than half of all patients with advanced urothelial cancer cannot receive standard, first-line cisplatin-based chemotherapy because of renal dysfunction, poor performance status, or other comorbidities. We assessed the activity and safety of first-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer. METHODS: In this multicentre, single-arm, phase 2 study (KEYNOTE-052), cisplatin-ineligible patients with advanced urothelial cancer who had not been previously treated with systemic chemotherapy were recruited from 91 academic medical centres in 20 countries...
September 26, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28915531/subclinical-hyperthyroidism-and-the-cardiovascular-disease
#13
Alessandro P Delitala
Thyroid hormone excess has complex metabolic effects, particularly on the cardiovascular system. Treatment of these conditions is universally suggested by international guidelines. Subclinical hyperthyroidism, defined by reduced or suppressed TSH levels in the presence of normal free thyroxine and free triiodothyronine values, is common in the general population and progressively increases with aging, being as high as 15.4% in subjects more than 75 years old and more frequent in subjects with nodular goiter...
October 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28899347/case-report-of-hyperglycemic-nonketotic-chorea-with-rapid-radiological-resolution
#14
H M M T B Herath, S P Pahalagamage, Sunethra Senanayake
BACKGROUND: Hemichorea is a rare manifestation of nonketotic hyperglycemia that usually affects elderly Asian women with poor glycemic control. Non-contrast computerized Tomography and T1- weighted Magnetic Resonance Imaging shows characteristic hyperintense basal ganglia lesions. CASE PRESENTATION: A Fifty-seven year old Sri Lankan female presented with a two-day history of right upper limb chorea. She had been diagnosed with diabetes mellitus one year ago, but was not on any treatment and did not have any micro vascular or macro vascular complications...
September 12, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28883858/association-between-low-thyroid-stimulating-hormone-posterior-cortical-atrophy-and-nitro-oxidative-stress-in-elderly-patients-with-cognitive-dysfunction
#15
Adriana E Bulboacă, Sorana D Bolboacă, Angelo C Bulboacă, Călin I Prodan
INTRODUCTION: Cortical atrophy is known to be a valuable sign of cognitive decline. The purpose of this study was to assess the association between low thyroid-stimulating hormone (TSH), posterior cortical atrophy (Koedam score - KS) and nitro-oxidative stress in elderly patients. MATERIAL AND METHODS: A study (SG) and a control group (CG), each subdivided by gender, were investigated. Subjects older than 59 years with low serum TSH level and with mild cognitive impairment were included in the SG...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28825577/-myxedema-coma
#16
Leonardo F L Rizzo, Daniela L Mana, Oscar D Bruno, Leonard Wartofsky
Hypothyroidism is a frequently diagnosed and simply treated disease. If not recognised, however, in time it may develop into the most severe manifestation of hypothyroidism known as myxedema coma. The term "myxedema coma" is generally seen as misleading since most patients do not initially present in a coma. The typical progression is lethargy evolving into stupor and, eventually, into coma with respiratory failure and hypothermia. It mainly affects elderly women, often occurring in winter and is relatively rare...
2017: Medicina
https://www.readbyqxmd.com/read/28796656/hypothyroidism-potentially-linked-to-cutaneous-squamous-cell-carcinoma-retrospective-study-at-a-single-tertiary-academic-medical-center
#17
Omeed Ahadiat, Shauna Higgins, Cameron Trodello, Guy Talmor, Niels Kokot, Ashley Wysong
BACKGROUND: There are multiple known risk factors for the development of cutaneous squamous cell carcinoma (SCC). OBJECTIVE: To determine whether patients with cutaneous SCC have a higher prevalence of hypothyroidism than the general US population. MATERIALS AND METHODS: A retrospective review was performed for patients seen at the University of Southern California with cutaneous SCC. Chart review was performed for the presence of hypothyroidism and thyroid replacement therapy before the diagnosis of SCC for each patient...
August 7, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28751368/functional-correlates-of-detailed-body-composition-in-healthy-elderly-subjects
#18
Corinna Geisler, Lisa Schweitzer, Manfred James Müller
Methods of body composition analysis (BCA) are now widely used to characterize health status, i.e. nutritional status, metabolic rates and cardio-metabolic risk factors. However, the functional correlates of individual body components have not been systematically analyzed. A 2-compartment model was assessed by air displacement plethysmographie, detailed body composition (BC)was measured by whole-body magnetic resonance imaging (MRI) in a healthy population of 40 Caucasians aged 65 to 81 years (20 males; body mass index range: 18...
July 27, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28721126/the-thyroid-gland-in-postmenopausal-women-physiology-and-diseases
#19
REVIEW
Małgorzata Gietka-Czernel
The incidence of most thyroid diseases: hypothyroidism, nodular goitre, and cancer is highest among postmenopausal and elderly women. The diagnosis of thyroid dysfunction in this group of patients is difficult because the symptoms can be nonspecific or common with menopausal and ageing complaints. In the interpretation of thyroid function tests the physiological changes in secretion and metabolism of thyrotropin (TSH) and thyroid hormones must be considered, as well as the influence of comorbidities. Unrecognised thyroid dysfunction leads to increased: cardiovascular risk, bone fractures, cognitive impairment, depression, and mortality...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28705270/serum-fetuin-a-levels-and-thyroid-function-inmiddle-aged-and-elderly-chinese
#20
Xin Ru Deng, Lin Ding, Tian Ge Wang, Min Xu, Jie Li Lu, Mian Li, Zhi Yun Zhao, Yu Hong Chen, Yu Fang Bi, Yi Ping Xu, Yu Xu
Serum fetuin-A levels are reportedly elevated in hyperthyroidism. However, there are few relevant epidemiologic studies. We conducted a cross-sectional study in Songnan community, China in 2009 to investigate the association between serum fetuin-A concentrations and thyroid function. A total of 2,984 participants aged 40 years and older were analyzed. Multivariable linear regression analysis revealed that serum fetuin-A concentra- tions were positively associated with log (free triiodothyronine) and were inversely associated with log (thyroid peroxidase antibody) after adjustment (both P < 0...
June 2017: Biomedical and Environmental Sciences: BES
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