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Thyroid elderly

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https://www.readbyqxmd.com/read/29319359/secondary-and-tertiary-preventions-of-thyroid-disease
#1
Fereidoun Azizi, Ladan Mehran, Farhad Hosseinpanah, Hossein Delshad, Atieh Amouzegar
INTRODUCTION: Secondary and tertiary preventions are concerned with the recognition of the disease process in a very early stage and delay in progression to complete disease and minimization of complications and the impact of illness. METHODS: All articles related to secondary and tertiary prevention of thyroid diseases were reviewed. Using related key words, articles published between 2001 and 2015 were evaluated, categorized, and analyzed. RESULTS: In secondary prevention, congenital hypothyroidism and subclinical hypo and hyperthyroidism are equally important...
January 10, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29319133/the-assessment-of-testosterone-and-radioisotopic-index-of-bone-metabolism-and-bone-mineral-density-in-men-with-testosterone-deficiency-after-one-year-of-testosterone-therapy
#2
Wieslaw Tryniszewski, Grzegorz Kamiński, Zbigniew Maziarz, Michal Nowak, Mariusz Gadzicki, Maciej Radek
BACKGROUND: Testosterone deficiency in men is characterized by typical symptoms of hypogonadism and negative influence on the preservation of bone mass. In this study, we analysed the relationship between testosterone concentration and bone metabolism. Moreover, we assessed the impact of one-year compensation of testosterone deficiency in elderly men on bone metabolism and bone mineral density. Radioisotopic methods of bone metabolism assessment provide new research opportunities. MATERIALS AND METHODS: Men with total testosterone concentration (TT) ≤ 3 ng/ml were included into this study...
January 10, 2018: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/29305431/case-of-nasogastric-tube-dysfunction
#3
Florian Rainer, Guenther Prenner, Lukas Peter Binder, Peter Fickert, Johannes Plank
CLINICAL PRESENTATION: An elderly female patient was admitted to intensive care for prolonged vasopressor therapy and mechanical ventilation after cardiac arrest and acute percutaneous coronary intervention. Antiplatelet, thyroid hormone replacement and statin therapies were administered through a 14-French nasogastric tube (Nestlé Health Science) and enteral feeding was initiated. Correct position of the nasogastric tube was confirmed radiologically. On the seventh day in the intensive care, our patient was seen to regurgitate soft crumbs into her mouth...
January 5, 2018: Gut
https://www.readbyqxmd.com/read/29251783/effect-of-metformin-on-hypothalamic-pituitary-thyroid-axis-activity-in-elderly-antipsychotic-treated-women-with-type-2-diabetes-and-subclinical-hypothyroidism-a-preliminary-study
#4
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
Metformin was found to reduce elevated serum thyrotropin levels, and this effect was partially determined by endogenous dopaminergic tone. The aim of this study was to compare the effect of metformin treatment on hypothalamic-pituitary-thyroid axis activity in elderly women with subclinical hypothyroidism treated with antipsychotic agents and not receiving this drug. The study population consisted of 34 elderly women with subclinical hypothyroidism, 16 of whom received antipsychotic drugs. Because of coexistent type 2 diabetes, these women were treated with metformin (2...
December 18, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29181346/phalangeal-fracture-during-attempted-dupuytrens-release-following-clostridial-collagenase-injection-case-report
#5
Laura W Lewallen, Marco Rizzo
Introduction: Dupuytren's disease can be a challenging condition for both patients and surgeons. Injectable collagen clostridium histolyticum was approved for clinical use by the Food and Drug Administration in 2010. A number of side effects have been described. In this case report, we present a complication of a proximal phalanx fracture which occurred during attempted release post injection. To the best of our knowledge, this is the first reported case of this particular complication...
July 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29180096/differentiating-merkel-cell-carcinoma-of-lymph-nodes-without-a-detectable-primary-skin-tumor-from-other-metastatic-neuroendocrine-carcinomas-the-electhip-criteria
#6
Thibault Kervarrec, Julia Zaragoza, Pauline Gaboriaud, Amélie Le Gouge, Agnès Beby-Defaux, Yannick Le Corre, Eva Hainaut-Wierzbiecka, Francois Aubin, Guido Bens, Patrick Michenet, Hervé Maillard, Antoine Touzé, Mahtab Samimi, Serge Guyétant
BACKGROUND: Merkel cell carcinoma MCC) can present as a cutaneous tumor or a lymph node without primary tumor MCCWP). MCCWP can be misinterpreted on histologic examination as lymph node metastasis LNM) from other neuroendocrine carcinomas LNMNECs). However, this distinction is crucial for therapeutic management. OBJECTIVE: To determine the discriminative criteria for differential diagnosis between MCCWP, LNM from cutaneous MCC and LNMNECs. METHODS: Clinical, morphologic, immunohistochemical data expression of cytokeratin AE1/AE3, 7, 19, 20; chromogranin A, thyroid transcription factor-1 [TTF-1]) and presence of Merkel Cell Polyomavirus MCPyV) immunohistochemistry and PCR) were compared in patients with MCCWP n=17), LNM from cutaneous MCC n=11) and LNMNEC n=20: lung, n=8; thyroid, n=7; digestive tract, n=3; other, n=2)...
November 24, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29174213/treatment-with-levothyroxin-in-subclinical-hypothyroidism-is-associated-with-increased-mortality-in-the-elderly
#7
Alon Grossman, Ilan Feldhamer, Joseph Meyerovitch
INTRODUCTION: It is uncertain whether subclinical hypothyroidism should be treated with levothyroxine, particularly in the elderly. This study evaluated the association between levothyroxine treatment and mortality in individuals 65years or older with subclinical hypothyroidism and TSH values <10mIU/L. METHODS: A case-control study in which patients 65years or older with TSH levels of 4.2-10mIU/L who died in the years 2012-2016 ('cases') were compared with matched individuals who did not die during this period ('controls')...
November 22, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29142852/thyroidectomy-in-elderly-patients-aged-%C3%A2-70-years
#8
REVIEW
Davide Inversini, Andrea Morlacchi, Giuseppinella Melita, Simona Del Ferraro, Carlo Boeri, Mattia Portinari, Antonino Cancellieri, Francesco Frattini, Antonio Giacomo Rizzo, Gianlorenzo Dionigi
Worldwide, the indications for thyroid surgery have been continuously extended among elderly patients in the last 20 years. The balance between treatment indication and surgical risk is certainly an interesting topic for every thyroid surgeon. This paper is a review of recent literature from January 2005 up to April 2017. We analyzed three principal subjects: indications for surgical treatment, medical complications and surgical complications. We can summarize the conclusions of our analysis, stating that age could not be considered as an absolute factor, but in relation to the comorbidities and the general clinical condition of the patient...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29131274/expression-level-and-clinical-significance-of-il-2-il-6-and-tgf-%C3%AE-in-elderly-patients-with-goiter-and-hyperthyroidism
#9
L-F Lv, H-Y Jia, H-F Zhang, Y-X Hu
OBJECTIVE: To investigate the level of expression and the clinical significance of IL-2 (interleukin-2), IL-6 (interleukin-6) and TGF-β (transforming growth factor-β) in elderly patients with goiter and hyperthyroidism. PATIENTS AND METHODS: Gender, age, course of disease, BMI (Body Mass Index), serum FT3 (Free triiodothyronine-3), FT4 (Free triiodothyronine-4), TT3 (Total triiodothyronine-3), TT4 (Total triiodothyronine-4), TSH (Thyroid Stimulating Hormone) and clinical manifestations on admission and other general clinical data and laboratory examination results were collected and statistically analyzed as case group in 128 elderly patients with goiter and hyperthyroidism...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29124061/diagnostics-of-thyroid-malignancy-and-indications-for-surgery-in-the-elderly-and-younger-counterparts-comparison-of-3-749-patients
#10
Krzysztof Kaliszewski, Dorota Diakowska, Marta Strutyńska-Karpińska, Beata Wojtczak, Michał Aporowicz, Zdzisław Forkasiewicz, Waldemar Balcerzak, Tadeusz Łukieńczuk, Paweł Domosławski
Background: It seems valuable for clinicians to know if diagnostics of thyroid malignancy (TM) and indications for surgery in the elderly patients differ from these in younger counterparts. Materials and Methods: Retrospective analysis of the medical records of 3,749 patients surgically treated for thyroid tumor. Data of patients with histopathology confirmed TM (n = 309) were studied. Results: The rate of cytological prediction to malignancy was more than three times higher in elderly women...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29121039/the-prevalence-and-determinants-of-multimorbidity-in-hospitalized-patients-with-heart-failure
#11
Olga Siga, Barbara Wizner, Karolina Piotrowicz, Małgorzata Fedyk-Łukasik, Tomasz Grodzicki
OBJECTIVE: The aim of this study was to assess the prevalence of multimorbidity and co-existed diseases in hospitalized patients with heart failure (HF) in relation to age and gender. METHODS: The nationwide cross-sectional survey had been conducted in Poland (April-November 2013), in 260 randomly selected hospital wards. A trained nurse contacted with one physician, drawn from the list of all doctors working in the selected hospital's wards, who completed the study questionnaires regarding to clinical characteristics of the last five HF patients, who were discharged from an internal or cardiology ward...
2017: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/29105624/effects-of-thyroid-hormone-replacement-therapy-on-thyroid-hormone-levels-and-electrocardiogram-changes-in-geriatric-patients-with-hypothyroidism
#12
Xianghong Zhai
This paper aims to analyze the effects of thyroid hormone replacement therapy on thyroid hormone levels and electrocardiogram changes in elderly patients with hypothyroidism. 48 elderly patients with hypothyroidism admitted to our hospital from January 2014 to December 2014 were selected as subjects. All the patients were treated with thyroid hormone replacement therapy. The changes of thyroid hormone levels and ECG parameters were compared before and after treatment. After treatment, serum thyroid stimulating hormone (TSH) was significantly lower than that before treatment, and the free triiodothyronine (FT3) and free thyroxine (FT4) were significantly higher than those before treatment (t=15...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29089349/thyroid-function-and-the-risk-of-atherosclerotic-cardiovascular-morbidity-and-mortality-the-rotterdam-study
#13
Arjola Bano, Layal Chaker, Francesco U S Mattace-Raso, Aad van der Lugt, M Arfan Ikram, Oscar H Franco, Robin P Peeters, Maryam Kavousi
RATIONALE: Thyroid hormones have been linked with various proatherogenic and antiatherogenic processes. However, the relationship of thyroid function with manifestations of atherosclerosis remains unclear. OBJECTIVE: To investigate the association of thyroid function with atherosclerosis throughout its spectrum; that is, subclinical atherosclerosis, incident atherosclerotic cardiovascular (ASCV) events, and ASCV mortality. METHODS AND RESULTS: This population-based study was embedded within the Rotterdam Study...
December 8, 2017: Circulation Research
https://www.readbyqxmd.com/read/29070621/fatal-outcome-of-an-anaplastic-thyroid-tumour
#14
Rafael García Carretero, Cristina Peña-Arce, Gabriel Martinez-Quesada, Javier Garcia-Alvarez
Anaplastic thyroid cancer is a rare form of thyroid cancer, known for its very poor prognosis, even with the appropriate management. It is very aggressive, with a tendency to invade locally and lymph node metastasis is often present at the time of diagnosis. We present an elderly patient, who presented with rapid enlarging neck mass, which, within weeks, led to his death. His family gave their consent to perform an autopsy, and here we describe and illustrate the profound aggressiveness of this tumour.
October 25, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29056955/comparison-of-long-term-outcome-between-patients-aged-65-years-vs-%C3%A2-65-years-after-atrial-fibrillation-ablation
#15
Zsuzsanna Kis, Anna Me Noten, Mihran Martirosyan, Astrid A Hendriks, Rohit Bhagwandien, Tamas Szili-Torok
BACKGROUND: Atrial fibrillation (AF) is the most frequent arrhythmia, and its prevalence is increasing with aging. We aimed to compare the long-term outcome data of patients < 65 years vs. ≥ 65 years who underwent catheter ablation (CA) for drug-refractory AF. METHODS: Consecutive patients with primary pulmonary vein isolation performed between March 2001 and December 2011, and those who completed a five-year of follow-up were divided into two groups: patients aged < 65 years into group 1, and patients aged ≥ 65 into group 2...
September 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29031027/evaluation-of-renal-perfusion-in-hyperthyroid-cats-before-and-after-radioiodine-treatment
#16
E Stock, S Daminet, D Paepe, E Buresova, E Vandermeulen, P Smets, L Duchateau, J H Saunders, K Vanderperren
BACKGROUND: Hyperthyroidism and chronic kidney disease (CKD) are common in elderly cats. Consequently, both diseases often occur concurrently. Furthermore, renal function is affected by thyroid status. Because changes in renal perfusion play an important role in functional renal changes in hyperthyroid cats, investigation of renal perfusion may provide novel insights. OBJECTIVES: To evaluate renal perfusion in hyperthyroid cats with contrast-enhanced ultrasound (CEUS)...
October 14, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29020715/diagnosis-and-management-of-polymyalgia-rheumatica
#17
REVIEW
Olwyn Jones, Fraser Birrell
Polymyalgia rheumatica (PMR) is a common inflammatory condition of unknown aetiology with a prevalence of 1 in 133 in the over 50s, and a female to male ratio of 2:1. Symptoms develop over a matter of weeks; typically bilateral shoulder or pelvic girdle pain and stiffness, that is worse in the mornings. Associated symptoms include low-grade fever, malaise, fatigue, low mood, poor appetite, and weight loss. There is no specific diagnostic test for PMR but the usual pattern is a commensurate rise in CRP and ESR...
December 2016: Practitioner
https://www.readbyqxmd.com/read/28967725/testicular-and-thyroid-function-as-survival-predictors-in-the-elderly-patient-candidate-to-surgery
#18
Antonio Aversa, Andrea Fabbri
The relationship between testosterone deficiency (TD) syndrome and surgical resilience has a great impact in the modern approach to male elderly patients. There is good evidence that low levels of T are a strong marker for cardiovascular risk; also, TD is frequently associated with increased cardiovascular and all-cause mortality especially in cardiac older frail men. Screening for low T should be mandatory in high risk groups candidate to surgery including those with diabetes, metabolic syndrome and obesity, even though benefits from T-treatment on survival rates are unclear...
July 18, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/28967485/first-line-pembrolizumab-in-cisplatin-ineligible-patients-with-locally-advanced-and-unresectable-or-metastatic-urothelial-cancer-keynote-052-a-multicentre-single-arm-phase-2-study
#19
Arjun V Balar, Daniel Castellano, Peter H O'Donnell, Petros Grivas, Jacqueline Vuky, Thomas Powles, Elizabeth R Plimack, Noah M Hahn, Ronald de Wit, Lei Pang, Mary J Savage, Rodolfo F Perini, Stephen M Keefe, Dean Bajorin, Joaquim Bellmunt
BACKGROUND: More than half of all patients with advanced urothelial cancer cannot receive standard, first-line cisplatin-based chemotherapy because of renal dysfunction, poor performance status, or other comorbidities. We assessed the activity and safety of first-line pembrolizumab in cisplatin-ineligible patients with locally advanced and unresectable or metastatic urothelial cancer. METHODS: In this multicentre, single-arm, phase 2 study (KEYNOTE-052), cisplatin-ineligible patients with advanced urothelial cancer who had not been previously treated with systemic chemotherapy were recruited from 91 academic medical centres in 20 countries...
September 26, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28915531/subclinical-hyperthyroidism-and-the-cardiovascular-disease
#20
Alessandro P Delitala
Thyroid hormone excess has complex metabolic effects, particularly on the cardiovascular system. Treatment of these conditions is universally suggested by international guidelines. Subclinical hyperthyroidism, defined by reduced or suppressed TSH levels in the presence of normal free thyroxine and free triiodothyronine values, is common in the general population and progressively increases with aging, being as high as 15.4% in subjects more than 75 years old and more frequent in subjects with nodular goiter...
October 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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