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Thyroid elderly

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https://www.readbyqxmd.com/read/29778090/massive-pericardial-effusion-without-cardiac-tamponade-due-to-subclinical-hypothyroidism-hashimoto-s-disease
#1
Panteleimon E Papakonstantinou, Nikolaos Gourniezakis, Christos Skiadas, Alexandros Patrianakos, Achilleas Gikas
CONTEXT: Hypothyroidism is a significant cause of pericardial effusion. However, large pericardial effusions due to hypothyroidism are extremely rare. Hormone replacement therapy is the cornerstone of treatment for hypothyroidism and regular follow-up of patients after initiation of the therapy is indicated. Herein, the case of a 70-year-old woman with a massive pericardial effusion due to Hashimoto's disease is presented. ISSUES: A 70-year-old female from a rural village on the island of Crete, Greece, was admitted to our hospital due to a urinary tract infection...
May 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29768912/association-between-urinary-sodium-levels-and-iodine-status-in-korea
#2
Jonghwa Ahn, Jang Ho Lee, Jiwoo Lee, Ji Yeon Baek, Eyun Song, Hye-Seon Oh, Mijin Kim, Suyeon Park, Min Ji Jeon, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Won Gu Kim
Background/Aims: To evaluate the association between the urinary sodium concentration and iodine status in different age groups in Korea. Methods: This nationwide, population-based, cross-sectional study used data from the Korean National Health and Nutrition Examination Survey (VI 2-3, 2014 to 2015). We included 3,645 subjects aged 10 to 75 years with normal kidney function and without a history of thyroid disease. Adequate iodine intake was defined as a urinary iodine/creatinine (I/Cr) ratio of 85 to 220 µg/g...
May 18, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29756245/age-related-differences-in-health-related-quality-of-life-among-thyroid-cancer-survivors-compared-with-a-normative-sample-results-from-the-profiles-registry
#3
Floortje Mols, Dounya Schoormans, Jan W A Smit, Romana T Netea-Maier, Thera P Links, Winette T A van der Graaf, Olga Husson
BACKGROUND: The purpose of this study was to compare general health-related quality of life (HR-QOL) of thyroid cancer survivors with a normative sample stratified by age at diagnosis (adolescents and young adults 18-35 years; middle-aged adults 36-64 years; elderly 65-84 years), and to compare general HR-QOL and disease-specific symptoms among adolescents and young adults, middle-aged adults, and elderly thyroid cancer survivors in an exploratory population-based cross-sectional study...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29733698/age-associated-increase-of-thyroid-hormone-receptor-%C3%AE-gene-promoter-methylation-coexists-with-decreased-gene-expression
#4
Eliza Pawlik-Pachucka, Monika Budzinska, Zofia Wicik, Anna Domaszewska-Szostek, Magdalena Owczarz, Malgorzata Roszkowska-Gancarz, Magdalena Gewartowska, Monika Puzianowska-Kuznicka
PURPOSE: It is not established if healthy aging of the thyroid axis is associated with alterations other than changes in hormone secretion. METHODS: The expression of thyroid hormone receptor β gene (THRB) was analyzed in peripheral blood mononuclear cells (PBMC) obtained from young, elderly, and long-lived individuals. The interaction between the 3'UTR of TRβ1 mRNA and selected miRNAs was measured using pmirGLO reporter vector. Methylation of the THRB CpG island was analyzed using methylation-sensitive restriction/RT-PCR and bisulfite sequencing methods...
May 7, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29717761/selenium-concentrations-and-mortality-among-community-dwelling-older-adults-results-from-ilsirente-study
#5
S Giovannini, G Onder, F Lattanzio, S Bustacchini, G Di Stefano, R Moresi, A Russo, R Bernabei, F Landi
BACKGROUND: Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population. OBJECTIVES: to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults. DESIGN AND SETTING: Data are from the 'Invecchiamento e Longevità nel Sirente' (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347)...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29698611/selenium-deficiency-in-mineral-rich-mid-western-australia
#6
Venkata Kodali
CONTEXT: Selenium is an essential micronutrient for human beings. Selenoproteins play a role in anti-oxidation and in maintaining immunity. Selenoproteins are distributed in all tissues, the most important of which are glutathione peroxidase, thioredoxin reductase and deiodinases. The deiodinases are selenium-dependent enzymes. ISSUES: An elderly man with lethargy and tiredness who had normal free thyroid hormone T4, thyroid-stimulating hormone and a low T3 with subnormal temperature and low selenium level...
April 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29688947/impact-of-patient-age-and-histological-type-on-radioactive-iodine-avidity-of-recurrent-lesions-of-differentiated-thyroid-carcinoma
#7
Kenichi Nakanishi, Toyone Kikumori, Noriyuki Miyajima, Yuko Takano, Sumiyo Noda, Dai Takeuchi, Shingo Iwano, Yasuhiro Kodera
BACKGROUND: Age is a prognostic factor for recurrent differentiated thyroid carcinoma (DTC) and may be related to radioactive iodine (RAI) nonavidity. Indications for molecular-targeted drugs (MTDs) are currently limited to RAI-refractory DTC. Demonstrating refractoriness to RAI, mainly indicated by RAI nonavidity, may be a barrier to the introduction of MTDs for elderly patients. The present study was conducted to evaluate the impact of age and histological type on the RAI avidity of recurrent lesions of DTC...
April 23, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29673554/subclinical-hypothyroidism-and-metabolic-risk-factors-association-a-health-examination-based-study-in-northern-taiwan
#8
Feng-Hsuan Liu, Jawl-Shan Hwang, Chang-Fu Kuo, Yu-Shien Ko, Szu-Tah Chen, Jen-Der Lin
BACKGROUND: Subclinical hypothyroidism (SCH) is defined as elevation in serum thyroid-stimulating hormone (TSH) levels despite normal serum levels of free thyroxine. It remains controversial whether people with SCH have higher total cholesterol and low-density lipoprotein cholesterol levels compared to normal-thyroid subjects. The aim of this study was to assess the metabolic risk factors for SCH. METHODS: Subjects were recruited from the health examination center of Chang Gung Memorial Hospital, Linkou, from January 1, 2010 to December 31, 2011...
February 2018: Biomedical Journal
https://www.readbyqxmd.com/read/29661337/thyroid-disorders-in-the-elderly-an-overall-summary
#9
REVIEW
Kevin Higgins
Medical care for elderly patients is often distinctly different from that of younger counterparts. This is no truer than in a thyroid disorder context, where patients are often asymptomatic and polypharmacy is a potential consideration. Understanding how treatment of these patients can deviate from common practices is an essential asset to any health care provider. The purpose of this article is to shed light on those deviations and address inherent complexities in caring for elderly patients in an effort to improve quality of care...
May 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29629339/metabolic-reprogramming-in-thyroid-carcinoma
#10
REVIEW
Raquel Guimaraes Coelho, Rodrigo S Fortunato, Denise P Carvalho
Among all the adaptations of cancer cells, their ability to change metabolism from the oxidative to the glycolytic phenotype is a hallmark called the Warburg effect. Studies on tumor metabolism show that improved glycolysis and glutaminolysis are necessary to maintain rapid cell proliferation, tumor progression, and resistance to cell death. Thyroid neoplasms are common endocrine tumors that are more prevalent in women and elderly individuals. The incidence of thyroid cancer has increased in the Past decades, and recent findings describing the metabolic profiles of thyroid tumors have emerged...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29572406/is-routine-measurement-of-tsh-hormone-in-hospitalized-patients-necessary
#11
Amir Bashkin, Eliran Yaakobi, Marina Nodelman, Ohad Ronen
TSH routine testing in hospitalized patients has low efficacy, but may be beneficial in a selected subgroup of patients. Our aim was to evaluate the efficacy of routine thyroid function tests among patients admitted to internal medicine departments. A retrospective study. A randomly selected cohort of hospitalized patients with abnormal TSH (thyroid stimulating hormone) blood tests drawn as part of admission protocol. Patient data was collected from the electronic medical files and analyzed for its efficacy...
March 23, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29551406/heart-failure-micronutrient-profile-and-its-connection-with-thyroid-dysfunction-and-nutritional-status
#12
Livia Fernandes de Lima, Fernando Barbosa, Marcus Vinícius Simões, Anderson Marliere Navarro
INTRODUCTION: Heart failure (HF) is a growing public health issue; its risk factors include inappropriate dietary intake of microelements such as iodine, selenium, zinc and iron, which may lead to thyroid dysfunction. OBJECTIVE: This study aimed to assess the correlation among the functional class stages of patients with HF, iodine, selenium, iron and zinc levels with the presence of thyroid dysfunction. METHODOLOGY: One hundred nine patients from the HF outpatient clinic of the Clinics Hospital of Ribeirão Preto whose blood and urine were collected for micronutrient analysis and laboratory tests were selected...
March 3, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29504734/estimation-of-vitamin-d-status-in-patients-with-secondary-and-primary-hypothyroidism-of-different-etiology
#13
Hanna Lawnicka, Anna Galant-Gdula, Ewelina Motylewska, Jan Komorowski, Jacek Swietoslawski, Henryk Stepien
BACKGROUND: Though vitamin D deficiency is a global problem with wide spectrum of severe public health consequences, inadequate vitamin D status still remains one of the most common and untreated medical conditions. Thyroid diseases, including hypothyroidism, also represent the most frequent endocrinopathies in general population. OBJECTIVES: To determine the vitamin D status in hypothyroid patients and to ascertain the status of thyroid hormone replacement. METHODS: The 25(OH)D concentrations (ECLIA) in 71 hypothyroid patients recruited in the Outpatient Clinic of Endocrinology or Department of Clinical Endocrinology were assessed...
February 2018: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29472048/oral-lichen-planus-differential-diagnoses-serum-autoantibodies-hematinic-deficiencies-and-management
#14
REVIEW
Chun-Pin Chiang, Julia Yu-Fong Chang, Yi-Ping Wang, Yu-Hsueh Wu, Shin-Yu Lu, Andy Sun
Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease that occurs more frequently in middle-aged and elderly female patients. Previous studies indicate that OLP is a T-cell dysfunction-induced localized autoimmune disease. Clinically, six types of OLP, namely reticular, papular, plaque-like, atrophic/erosive, ulcerative, and bullous types, can be identified. OLP more commonly affects buccal mucosa, tongue, and gingiva. It always has a bilateral and symmetric distribution of the oral lesions...
February 19, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29456854/novel-braf-mutation-in-melanoma-a-case-report
#15
Serena Trubini, Alessandro Ubiali, Carlo Terenzio Paties, Luigi Cavanna
In melanoma, a number of specific genetic and genomic aberrations have been identified to be important in tumorigenesis. In particular, the mutant B-Raf proto-oncogene, Serine/Threonine kinase (BRAF) gene is the target of tailored therapy with kinase inhibitor molecules. Identification of the array of mutations in patients with melanoma will be useful in determining a genetic profile of the tumor with potential implications for treatment decisions. A rare aminoacidic insertion in codon 599 of the BRAF gene (c...
March 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29445829/-treatment-of-latent-hypothyroidism-in-the-elderly-thyroid-hormone-replacement-for-untreated-older-adults-with-subclinical-hypothyroidism-trust
#16
D Führer, S Nitschmann
No abstract text is available yet for this article.
March 2018: Der Internist
https://www.readbyqxmd.com/read/29412392/coexistence-of-diffuse-large-b-cell-lymphoma-and-papillary-thyroid-carcinoma-in-a-patient-affected-by-hashimoto-s-thyroiditis
#17
Maria Trovato, Giuseppe Giuffrida, Antonino Seminara, Simone Fogliani, Vittorio Cavallari, Rosaria Maddalena Ruggeri, Alfredo Campennì
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. On the contrary, primary thyroid lymphoma (PTL) is a rare disease, accounting for 2% to 5% of all thyroid malignancies. Despite several cases in which both PTC and PTL arise in the setting of Hashimoto's thyroiditis (HT), the coexistence of both tumors in HT patients is very rare. Herein we report the case of a 66-year-old woman with long-standing nodular HT under replacement therapy, who presented with a fast, painless enlargement in the right anterior side of the neck...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29401546/-medical-treatment-of-thyroid-nodule
#18
Karl-Michael Derwahl
Whereas in regions with sufficient iodide intake treatment of thyroid nodules with levothyroxine has been almost completely abandoned and is also not further recommended by guidelines, medical treatment may be still indicated in Germany as recently demonstrated by randomized, placebo-controlled LISA study.A major reason for this is mild iodide deficiency in patients with thyroid nodules. In LISA study a combined therapy of levothyroxine and iodide resulted in an at least 50 % reduction of nodular volume in 21,6 % of treated patient compared to in only 5,2 % of placebo-treated patients...
February 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29396842/associations-between-age-and-50-trace-element-contents-and-relationships-in-intact-thyroid-of-males
#19
Vladimir Zaichick, Sofia Zaichick
BACKGROUND: It is unclear why a prevalence of thyroid dysfunction is higher in the elderly as compared to the younger population. An excess or deficiency of trace element contents in thyroid may play important role in goitre- and carcinogenesis of gland. AIM: To examine the variation with age of the mass fraction of 50 trace elements in intact (normal) male thyroid. METHOD: Samples of thyroid parenchyma obtained from 72 healthy males (mean age 37...
February 2, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29362636/demographic-and-clinical-features-of-thyroid-carcinomas-in-republic-of-macedonia-1999-2010
#20
Tanja Makazlieva, Olivija Vaskova, Venjamin Majstorov, Sinisha Stojanoski, Nevena Manevska, Rubens Jovanovic
BACKGROUND: Thyroid carcinomas (TC) are the most common endocrine malignancies. In some parts of the world, the incidence of TCs has increased over the past few decades, especially in females according to some studies. AIM: We have set as the objective for our study to analyse the demographic, ultrasound features, thyroid hormonal status and frequency of thyroid carcinomas in the Republic of Macedonia according to histopathological type. MATERIALS AND METHODS: Retrospective analysis of medical data from all diagnosed and treated patients with TC at the Institute of Pathophysiology and Nuclear Medicine for the period 1999-2010 was performed...
December 15, 2017: Open Access Macedonian Journal of Medical Sciences
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