Mike M Sathekge, Ismaheel O Lawal, Chandrasekhar Bal, Frank Bruchertseifer, Sajana Ballal, Giuseppe Cardaci, Cindy Davis, Mathias Eiber, Türkay Hekimsoy, Otto Knoesen, Clemens Kratochwil, Nat P Lenzo, Johncy Mahapane, Letjie C Maserumule, Amanda H Mdlophane, Kgomotso M G Mokoala, Honest Ndlovu, Vineet Pant, Hendrik Rathke, Janet Reed, Ishita B Sen, Aviral Singh, Ashwani Sood, Robert Tauber, Parul Thakral, Madhav Prasad Yadav, Alfred Morgenstern
BACKGROUND: Actinium-225 (225 Ac) prostate-specific membrane antigen (PSMA) radioligand therapy (RLT) is a novel therapy for metastatic castration-resistant prostate cancer (mCRPC). We aimed to report the safety and antitumour activity of 225 Ac-PSMA RLT of mCRPC in a large cohort of patients treated at multiple centres across the world. METHODS: This retrospective study included patients treated at seven centres in Australia, India, Germany, and South Africa. We pooled data of consecutive patients of any age and Eastern Cooperative Oncology Group performance status with histopathologically confirmed adenocarcinoma of the prostate who were treated with one or more cycles of 8 MBq 225 Ac-PSMA RLT administered intravenously for mCRPC...
February 2024: Lancet Oncology