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chemotherapy induced anaemia

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https://www.readbyqxmd.com/read/27855097/combination-with-intravenous-iron-supplementation-or-doubling-erythropoietin-dose-for-patients-with-chemotherapy-induced-anaemia-inadequately-responsive-to-initial-erythropoietin-treatment-alone-study-protocol-for-a-randomised-controlled-trial
#1
Lin Chen, Hong Jiang, Wei Gao, Ye Tu, Ying Zhou, Xi Li, Zhe Zhu, Qixin Jiang, Haifeng Zhan, Jiangming Yu, Chuangang Fu, Yong Gao
INTRODUCTION: Erythropoietin (EPO) is a commonly used option in the treatment of chemotherapy-induced anaemia (CIA). However, ∼30-50% of patients fail to achieve an adequate response after initial treatment. Prior studies have demonstrated that intravenous iron might synergistically improve therapeutic response to EPO treatment in this patient population. METHODS AND ANALYSIS: We will perform this multicentre, randomised, open-label, parallel-group, active controlled non-inferiority study to compare the two combination therapies of EPO plus intravenous iron regimen versus doubling the dose of EPO in patients with CIA who have an inadequate response to initial EPO treatment at a routine dose...
October 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27699026/clinical-and-imaging-characteristics-of-53-ulcers-of-post-radiation-nasopharyngeal-necrosis-in-patients-with-nasopharyngeal-carcinoma
#2
Fengqin Yan, Zhimin Ye, Fangzheng Wang, Lei Wang, Weiyang Li, Zhenfu Fu
It is widely accepted that a mucosal ulcer induced by radiation (RIMU) is the predominant type of post-radiation nasopharyngeal ulcer in patients with nasopharyngeal carcinoma (NPC) who underwent radiotherapy (RT); however, another type of ulcer, an ulcer of post-radiation nasopharyngeal necrosis (UPRNN), has rarely been reported for patients with NPC. In the present study, the clinical and imaging features of 53 patients who were treated at the Zhejiang Provincial Cancer Center (Zhejiang Cancer Hospital, Hangzhou, China) between March 2009 and December 2015, and who were diagnosed with UPRNN, were reviewed...
October 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27206325/risk-of-venous-thromboembolism-in-cancer-patients-treated-with-epoetins-or-blood-transfusions
#3
Antonios Douros, Kathrin Jobski, Bianca Kollhorst, Tania Schink, Edeltraut Garbe
AIMS: Anaemia is common in cancer patients, with treatments including epoetins and blood transfusions. Although an increased risk of venous thromboembolism (VTE) has been associated with both therapeutics, studies comparing the risk of VTE between epoetins and transfusions in cancer patients are lacking. METHODS: A nested case-control study investigated this risk using the German Pharmacoepidemiological Research Database. Cohort members were incident cancer patients receiving first time treatment with epoetin or transfusion...
September 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/26907163/the-effectiveness-and-cost-effectiveness-of-erythropoiesis-stimulating-agents-epoetin-and-darbepoetin-for-treating-cancer-treatment-induced-anaemia-including-review-of-technology-appraisal-no-142-a-systematic-review-and-economic-model
#4
Louise Crathorne, Nicola Huxley, Marcela Haasova, Tristan Snowsill, Tracey Jones-Hughes, Martin Hoyle, Simon Briscoe, Helen Coelho, Linda Long, Antonieta Medina-Lara, Ruben Mujica-Mota, Mark Napier, Chris Hyde
BACKGROUND: Anaemia is a common side effect of cancer treatments and can lead to a reduction in quality of life. Erythropoiesis-stimulating agents (ESAs) are licensed for use in conjunction with red blood cell transfusions to improve cancer treatment-induced anaemia (CIA). OBJECTIVE: To investigate the effectiveness and cost-effectiveness of ESAs in anaemia associated with cancer treatment (specifically chemotherapy). DATA SOURCES: The following databases were searched from 2004 to 2013: The Cochrane Library, MEDLINE, MEDLINE In-Process & Other Non-Indexed Citations, EMBASE, Web of Science, Cumulative Index to Nursing and Allied Health Literature, British Nursing Index, Health Management Information Consortium, Current Controlled Trials and ClinicalTrials...
February 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/26744538/pathophysiology-of-tumour-induced-microangiopathic-haemolytic-anaemia
#5
Pavani Chalasani, Jennifer M Segar, Marilyn Marron, Alison Stopeck
Cancer-associated microangiopathic haemolytic anaemia (CA-MAHA) is a syndrome characterised by Coombs-negative haemolytic anaemia and thrombocytopenia. It is primarily seen in advanced solid tumours and is distinct from thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome. Diagnosis is often delayed and patients have a high mortality. We present the case of CA-MAHA in a patient with metastatic breast cancer treated successfully with early initiation of chemotherapy. In addition, we report longitudinal laboratory evaluation of circulating tumour cells and microparticles and suggest a hypothesis for the mechanism behind CA-MAHA...
January 7, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26578732/pre-treatment-lymphocytopaenia-is-an-adverse-prognostic-biomarker-in-muscle-invasive-and-advanced-bladder-cancer
#6
N Joseph, S J Dovedi, C Thompson, J Lyons, J Kennedy, T Elliott, C M West, A Choudhury
BACKGROUND: Pre-treatment lymphocytopaenia may result from cytokines secreted by the tumour microenvironment in association with aggressive tumour biology. We sought to establish the prognostic significance of lymphocytopaenia in muscle-invasive and advanced bladder cancer. PATIENTS AND METHODS: Seventy-four patients with muscle-invasive bladder cancer treated with radical chemoradiotherapy and 131 patients with advanced bladder cancer treated with palliative chemotherapy were included in the study...
February 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/26426164/biosimilar-epoetin-zeta-in-oncology-and-haematology-development-and-experience-following-6-years-of-use
#7
REVIEW
Mauricette Michallet, Christoph Losem
Chemotherapy-induced anaemia is frequent in cancer patients, with severity depending on the extent of the disease and intensity of treatment. Clinical guidelines recommend erythropoietin therapy to treat or prevent anaemia in some oncology/haematology patients being treated with chemotherapy. The patent expiry of the first-generation erythropoietins has led to the development of biosimilar products, i.e. therapeutic proteins exhibiting comparable quality, safety and efficacy to an existing reference biological medicine, the patent of which has expired...
2016: Acta Haematologica
https://www.readbyqxmd.com/read/26272769/safety-and-efficacy-of-rolapitant-for-prevention-of-chemotherapy-induced-nausea-and-vomiting-after-administration-of-cisplatin-based-highly-emetogenic-chemotherapy-in-patients-with-cancer-two-randomised-active-controlled-double-blind-phase-3-trials
#8
RANDOMIZED CONTROLLED TRIAL
Bernardo L Rapoport, Martin R Chasen, Cesare Gridelli, Laszlo Urban, Manuel R Modiano, Ian D Schnadig, Allen Poma, Sujata Arora, Vikram Kansra, Lee S Schwartzberg, Rudolph M Navari
BACKGROUND: Highly emetogenic chemotherapy induces emesis in almost all patients in the absence of prophylaxis. Guidelines recommend use of a neurokinin-1 (NK-1) receptor antagonist in conjunction with a 5-HT3 receptor antagonist and corticosteroid in patients receiving highly emetogenic chemotherapy. We aimed to assess rolapitant, an NK-1 receptor antagonist, for prevention of chemotherapy-induced nausea and vomiting in patients with cancer after administration of cisplatin-based highly emetogenic chemotherapy...
September 2015: Lancet Oncology
https://www.readbyqxmd.com/read/26232556/erythropoietin-protects-neuroblastoma-cells-against-etoposide-and-vincristine-by-activating-erk-and-akt-pathways-but-has-no-effect-in-kidney-cells
#9
Maria Jose Vazquez-Mellado, Cecilia Aguilar, Leticia Rocha-Zavaleta
AIMS: Chemotherapy induces anaemia in neuroblastoma patients. Cancer-associated anaemia may be treated with recombinant erythropoietin. However, the potential effects of erythropoietin on neuroblastoma and kidney cells have not been extensively evaluated. The present study was designed to investigate the effect of erythropoietin on the proliferation, and protection against vincristine- and etoposide-induced cell death in neuroblastoma (MSN), and embryonic kidney (HEK 293) cells. MAIN METHODS: The expression of erythropoietin and its receptor in MSN and HEK 293 was analysed by RT-PCR, immunocytochemistry, and Western blotting...
September 15, 2015: Life Sciences
https://www.readbyqxmd.com/read/26011836/the-configuration-of-biomolecular-markers-in-cancer-of-the-uterine-cervix-personalized-therapy-monitoring-and-prognosis
#10
V M Prunoiu, M A Marincaş, C Cirimbei, S Ionescu, S Zurac, M Radu, R Nicolaescu, E Brătucu, N D Straja
INTRODUCTION: The paper deals with the diagnosis of some aggressive forms of uterine cervix cancers, resistant to radio chemotherapy, using biomolecular markers.For this study, the destruction of tumours in stages II-IIIBis carried out by hyperthermia induced by different sources of energy. The aimed targets are toembed a quick and simple technique of haemostas isused in bleeding uterine cervix tumours associated with acute an aemiain the treatment protocols and to identify biomolecular criteria revealing tumour aggressiveness and treatment response...
March 2015: Chirurgia
https://www.readbyqxmd.com/read/25943156/origins-and-implications-of-neglect-of-g6pd-deficiency-and-primaquine-toxicity-in-plasmodium-vivax-malaria
#11
REVIEW
Kevin Baird
Most of the tens of millions of clinical attacks caused by Plasmodium vivax each year likely originate from dormant liver forms called hypnozoites. We do not systematically attack that reservoir because the only drug available, primaquine, is poorly suited to doing so. Primaquine was licenced for anti-relapse therapy in 1952 and became available despite threatening patients having an inborn deficiency of glucose-6-phosphate dehydrogenase (G6PD) with acute haemolytic anaemia. The standard method for screening G6PD deficiency, the fluorescent spot test, has proved impractical where most malaria patients live...
May 2015: Pathogens and Global Health
https://www.readbyqxmd.com/read/25899311/olaparib-a-review-of-its-use-as-maintenance-therapy-in-patients-with-ovarian-cancer
#12
REVIEW
James E Frampton
Olaparib (Lynparza™) is a first-in-class, orally-active, small molecule, poly (ADP-ribose) polymerase inhibitor that induces synthetic lethality in homozygous BRCA-deficient cells. In the EU, the capsule formulation of olaparib is indicated as monotherapy for the maintenance treatment of adult patients with platinum-sensitive, relapsed, BRCA-mutated (germline and/or somatic), high-grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to platinum-based chemotherapy...
April 2015: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
https://www.readbyqxmd.com/read/25893427/risk-evaluation-mitigation-strategy-impact-of-application-of-the-food-and-drug-adminstration-s-strategy-on-use-of-erythropoiesis-stimulating-agents-and-transfusion-in-patients-with-chemotherapy-induced-anaemia
#13
K Hollingsworth, M C Romney, A Crawford, J McAna
WHAT IS KNOWN AND OBJECTIVE: The Food and Drug Administration (FDA) instituted a risk evaluation mitigation strategy (REMS) for erythropoiesis-stimulating agent (ESA) use in patients with cancer in February 2010. Implementation of REMS was considered likely to reduce ESA use and increase red blood cell transfusions. We aimed to quantify ESA and transfusion use pre- and post-REMS. METHODS: A retrospective data analysis was conducted using the Medicare 5% Sample Database from 2008 through 2011...
June 2015: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/25872413/severe-and-fatal-adverse-events-risk-associated-with-rituximab-addition-to-b-cell-non-hodgkin-s-lymphoma-b-nhl-chemotherapy-a-meta-analysis
#14
Qingling Hua, Yanzhe Zhu, Hu Liu
PURPOSE: Rituximab is a monoclonal antibody targetting the CD20 antigen with the ability to increase overall remission (OR) in B-cell non-Hodgkin's lymphoma (B-NHL). A systematic review and meta-analysis were conducted to determine the risk of the most clinically relevant severe and fatal adverse events (AEs) associated with the use of rituximab in the treatment of B-NHL. PATIENTS AND METHODS: We included phase III clinical trials that used chemotherapy in combination with rituximab or chemotherapy alone as for B-NHL...
2015: Journal of Chemotherapy
https://www.readbyqxmd.com/read/25841398/the-latest-meta-analysis-on-the-use-of-erythritopoiesis-stimulating-agents-in-chemotherapy-induced-anaemia-brings-new-light-on-the-safety
#15
Pere Gascon
No abstract text is available yet for this article.
December 2012: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/25770814/aprepitant-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting-in-children-a-randomised-double-blind-phase-3-trial
#16
RANDOMIZED CONTROLLED TRIAL
Hyoung Jin Kang, Susan Loftus, Arlene Taylor, Cara DiCristina, Stuart Green, Christian Michel Zwaan
BACKGROUND: Oral aprepitant, a neurokinin-1 receptor antagonist, is recommended in combination with other anti-emetic agents for the prevention of nausea and vomiting associated with moderately or highly emetogenic chemotherapy in adults, but its efficacy and safety in paediatric patients are unknown. We did this phase 3 trial to examine the safety and efficacy of such treatment in children. METHODS: In this final analysis of a phase 3, randomised, multicentre, double-blind study, patients aged 6 months to 17 years with a documented malignancy who were scheduled to receive either moderately or highly emetogenic chemotherapy were randomly assigned with an interactive voice response system to an age-based and weight-based blinded regimen of aprepitant (125 mg for ages 12-17 years; 3·0 mg/kg up to 125 mg for ages 6 months to <12 years) plus ondansetron on day 1, followed by aprepitant (80 mg for ages 12-17 years; 2·0 mg/kg up to 80 mg for ages 6 months to <12 years) on days 2 and 3, or placebo plus ondansetron on day 1 followed by placebo on days 2 and 3; addition of dexamethasone was allowed...
April 2015: Lancet Oncology
https://www.readbyqxmd.com/read/25668003/tailoring-heated-intraperitoneal-mitomycin-c-for-peritoneal-metastases-originating-from-colorectal-carcinoma-a-translational-approach-to-improve-survival
#17
R Kwakman, E M V de Cuba, J P de Winter, I H J T de Hingh, P M Delis-van Diemen, M Tijssen, M A Rooimans, O Krijgsman, B Carvalho, G J Peters, H J Bonjer, G A Meijer, E A Te Velde
BACKGROUND: Patients with peritoneal metastases (PMs) originating from colorectal carcinoma (CRC) are curatively treated by cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) with mitomycin C (MMC). We aim to improve patient selection for HIPEC by predicting MMC sensitivity. METHODS: The MMC sensitivity was determined for 12 CRC cell lines and correlated to mRNA expression of 37 genes related to the Fanconi anaemia (FA)-BRCA pathway, ATM-ATR pathway and enzymatic activation of MMC...
March 3, 2015: British Journal of Cancer
https://www.readbyqxmd.com/read/25559985/consolidation-hyperthermic-intraperitoneal-chemotherapy-and-maintenance-chemotherapy-following-laparoscopic-cytoreductive-surgery-in-the-treatment-of-ovarian-carcinoma
#18
Mark A Rettenmaier, Alberto A Mendivil, Lisa N Abaid, John V Brown Iii, Amber M Wilcox, Bram H Goldstein
PURPOSE: Hyperthermic intraperitoneal chemotherapy (HIPEC) is an intriguing method of delivery wherein the cytotoxic agent is continuously heated and circulated throughout the peritoneum in an attempt to improve efficacy. Despite the potential of HIPEC in the treatment of ovarian cancer, there are limited safety, feasibility and survival data involving this procedure, particularly in conjunction with maintenance chemotherapy. PATIENTS AND METHODS: We retrospectively evaluated ovarian cancer patients who underwent laparoscopic debulking surgery, attained a complete response to their primary chemotherapy and subsequently received consolidation HIPEC with carboplatin area under the curve of 10 (AUC of 10) and a planned 12 cycles of paclitaxel (135 mg/m(2)) maintenance chemotherapy...
February 2015: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/25471063/complete-remission-of-schnitzler-syndrome-and-waldenstr%C3%A3-m-macroglobulinemia-under-rituximab-cyclophosphamide-dexamethasone
#19
Achille Aouba, Claire Pressiat, Maria Pricopi, Sophie Georgin-Lavialle, François Boue, Maria-Angela Lievre-Castilla, Anne Marfaing-Koka, Sophie Prevot, Audrey Decottignies
In Schnitzler syndrome, which is mostly diagnosed with a low and asymptomatic monoclonal peak, anakinra has always exhibited a complete but only transient control of the auto-inflammatory signs, which are induced by interleukin (IL)-1 auto-activation. We focused on the treatment of a case of Schnitzler syndrome with moderate macroglobulinemia peak. Anakinra failed to improve the severe inflammatory anaemia and the dysglobulinemia, but rituximab-dexamethasone-cyclophosphamide chemotherapy alone allowed a complete response...
2015: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/25081347/azathioprine-and-6-mercaptopurine-for-maintenance-of-surgically-induced-remission-in-crohn-s-disease
#20
REVIEW
Morris Gordon, Kelly Taylor, Anthony K Akobeng, Adrian G Thomas
BACKGROUND: Crohn's disease (CD) is a chronic relapsing inflammatory condition. Many patients fail to achieve remission with medical management and require surgical interventions. Purine analogues have been used to maintain surgically-induced remission in CD, but the effectiveness of these agents is unclear. OBJECTIVES: The objectives were to evaluate the efficacy and safety of purine analogues for maintenance of surgically-induced remission in CD. SEARCH METHODS: We searched the following databases from inception to 30 April 2014: PubMed, MEDLINE, EMBASE, CENTRAL, and the Cochrane Inflammatory Bowel Disease and Functional Bowel Disorders Group Specialized Trials Register)...
2014: Cochrane Database of Systematic Reviews
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