Sattya N Talukdar, Jaspreet Osan, Ken Ryan, Bryon Grove, Danielle Perley, Bony D Kumar, Shirley Yang, Sydney Dallman, Lauren Hollingsworth, Kristina L Bailey, Masfique Mehedi
Viral infection, particularly respiratory syncytial virus (RSV), causes inflammation in the bronchiolar airways (bronchial wall thickening, also known as bronchiolitis). This bronchial wall thickening is a common pathophysiological feature in RSV infection, but it causes more fatalities in infants than in children and adults. However, the molecular mechanism of RSV-induced bronchial wall thickening remains unknown, particularly in healthy adults. Using highly differentiated pseudostratified airway epithelium generated from primary human bronchial epithelial cells, we revealed RSV-infects primarily ciliated cells...
February 4, 2023: Virus Research