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Mild ovarian stimulation

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https://www.readbyqxmd.com/read/29121269/individualized-versus-standard-fsh-dosing-in-women-starting-ivf-icsi-an-rct-part-2-the-predicted-hyper-responder
#1
Simone C Oudshoorn, Theodora C van Tilborg, Marinus J C Eijkemans, G Jur E Oosterhuis, Jaap Friederich, Marcel H A van Hooff, Evert J P van Santbrink, Egbert A Brinkhuis, Jesper M J Smeenk, Janet Kwee, Corry H de Koning, Henk Groen, Cornelis B Lambalk, Ben Willem J Mol, Frank J M Broekmans, Helen L Torrance
STUDY QUESTION: Does a reduced FSH dose in women with a predicted hyper response, apparent from a high antral follicle count (AFC), who are scheduled for IVF/ICSI lead to a different outcome with respect to cumulative live birth rate and safety? SUMMARY ANSWER: Although in women with a predicted hyper response (AFC > 15) undergoing IVF/ICSI a reduced FSH dose (100 IU per day) results in similar cumulative live birth rates and a lower occurrence of any grade of ovarian hyperstimulation syndrome (OHSS) as compared to a standard dose (150 IU/day), a higher first cycle cancellation rate and similar severe OHSS rate were observed...
November 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29120551/current-medical-strategies-in-the-prevention-of-ovarian-hyperstimulation-syndrome
#2
Miro Kasum, Slavko Orešković, Daniela Franulić, Ermin Čehić, Albert Lila, Goran Vujić, Franjo Grgić
The purpose of this review is to analyze current medical strategies in the prevention of ovarian hyperstimulation syndrome (OHSS) during ovarian stimulation for in vitro fertilization. Owing to contemporary preventive measures of OHSS, the incidence of moderate and severe forms of the syndrome varies between 0.18% and 1.40%. Although none of medical strategies is completely effective, there is high-quality evidence that replacing human chorionic gonadotropin (hCG) by gonadotropin-releasing hormone (GnRH) agonists after GnRH antagonists and moderate- quality evidence that GnRH antagonist protocols, dopamine agonists and mild protocols reduce the occurrence of OHSS...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29105483/fsh-dose-to-stimulate-different-patient-ages-when-less-is-more
#3
Edson Borges, Bianca F Zanetti, Amanda S Setti, Daniela Paf Braga, Rita de Cássia S Figueira, Assumpto Iaconelli
OBJECTIVE: To determine the effect of FSH doses on intracytoplasmic sperm injection (ICSI) outcomes according to the age of the patient. METHODS: Patients undergoing controlled ovarian stimulation (COS) for ICSI cycles in a university-affiliated in vitro fertilization center were split into age groups: ≤35 y.o. (n=1523); >35 and ≤38 y.o. (n=652); >38 and ≤40 y.o. (n=332); and >40 y.o. (n=370). The effect of FSH dose on COS, laboratorial and clinical outomes was determined by linear regression models...
November 6, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29030068/double-ovarian-stimulation-during-the-follicular-and-luteal-phase-in-women-%C3%A2-38-years-a-retrospective-case-control-study
#4
Conghui Liu, Hong Jiang, Wenxiang Zhang, Huiqun Yin
Previous studies have shown that double ovarian stimulation could obtain more oocytes in women with poor ovarian response. This retrospective case-control study aimed to investigate the efficacy of double ovarian stimulation in older women. One hundred and sixteen women aged ≥38 years who received double ovarian stimulation were assigned to the study, with 103 divided into four groups according to follicular-phase ovarian stimulation protocols, including gonadotrophin-releasing hormone agonist short protocol (n = 27), gonadotrophin-releasing hormone antagonist protocol (n = 32), mild stimulation protocol (n = 21) and medrocyprogesterone acetate (MPA) pituitary down-regulation protocol (n = 23)...
August 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28965550/in%C3%A2-vitro-fertilization-treatments-with-the-use-of-clomiphene-citrate-or-letrozole
#5
REVIEW
Jigal Haas, Robert F Casper
There has been increasing interest in combining the oral agents clomiphene citrate (CC) and letrozole with gonadotropins in IVF: for poor responders to reduce the amount of gonadotropins used, and in normal responders to reduce the incidence of ovarian hyperstimulation (OHSS). In normal responders, mild stimulation with the use of CC and gonadotropins was found to decrease the number of oocytes retrieved and result in good pregnancy rates, but in most studies the cumulative pregnancy rate was lower compared with conventional ovarian stimulation when frozen embryo transfers were considered...
October 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28965549/mild-stimulation-for-in%C3%A2-vitro-fertilization
#6
REVIEW
Geeta Nargund, Adrija Kumar Datta, Bart C J M Fauser
It has been proven that the use of high gonadotropin dose does not necessarily improve the final outcome of IVF. Mild ovarian stimulation is based on the principle of optimal utilization of competent oocytes/embryos and endometrial receptivity. There is growing evidence that the pregnancy or live birth rates with mild-stimulation protocols are comparable to those with conventional IVF; the cumulative pregnancy outcome has been shown to be no different, despite having fewer numbers of oocytes or embryos available with milder ovarian stimulation...
October 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28948397/neonatal-outcomes-and-congenital-malformations-in-children-born-after-human-menopausal-gonadotropin-and-medroxyprogesterone-acetate-treatment-cycles
#7
Jie Zhang, Xiaoyan Mao, Yun Wang, Qiuju Chen, Xuefeng Lu, Qingqing Hong, Yanping Kuang
PURPOSE: To investigate neonatal outcomes and congenital malformations in children born after in vitro fertilization (IVF) and vitrified embryo transfer cycles using human menopausal gonadotrophin and medroxyprogesterone acetate (hMG + MPA) treatment. METHODS: We performed a retrospective cohort study including 4596 live born babies. During January 2014-June 2016, children born after either hMG + MPA treatment, gonadotropin releasing hormone agonist short protocol, or mild ovarian stimulation were included...
December 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28911928/introduction-contemporary-approaches-to-alternative-ovarian-stimulation-strategies-for-in%C3%A2-vitro-fertilization
#8
Richard J Paulson
In the current practice of IVF, the vast majority of cycles use some form of controlled ovarian stimulation before egg retrieval to increase the number of embryos available for transfer or cryopreservation. However, the optimal stimulation regimen has not been established. This month's Views and Reviews presents five different approaches to alternative ovarian stimulation strategies. These include mild stimulation regimens, modified natural cycles, stimulation with oral agents, in vitro maturation (in the absence of stimulation), and finally, a proposal for patient-tailored ovarian stimulation...
October 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28898686/the-impact-of-ovulation-induction-and-ovarian-stimulation-on-the-risk-of-pregnancy-induced-hypertension-and-on-neonatal-outcomes-a-case-control-study
#9
Lionel Carbillon, Heloise Gronier, Isabelle Cedrin-Durnerin, Isabelle Pharisien, Minh T Nguyen, Paul Valensi, Emmanuel Cosson
OBJECTIVES: To study the role of ovarian stimulation procedures on the risk of pregnancy-induced hypertension, gestational diabetes mellitus and neonatal outcomes according to women's characteristics and the causes of infertility. DESIGN: Retrospective, observational, case/control study. PATIENTS: Spontaneous pregnancies (group A, n=8107), pregnancies achieved after mild ovarian ovulation induction without other Assisted Reproductive Technology (ART) procedures (group B, n=44), pregnancies after mild ovarian stimulation and ART procedures (group C, n=53) or pregnancies after multi (>2) follicular stimulation with gonadotrophin therapy and ART procedures (group D, n=133); all of the groups had identical protocols for prenatal care...
September 1, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28752967/-expression-of-hsp70-in-kunming-mouse-embryos-stimulated-by-chronic-mild-anticipatory-stress
#10
Xiao-Hong Li, Shan Luo, Wei Fan, Xun Zeng, Yu Bai, Lang Qin, Shang-Wei Li
OBJECTIVE: To measure the expression of heat shock protein 70 (HSP70) in mice embryos with the stimulation of chronic mild anticipatory stress (CUMS) to female Kunming mice. METHODS: Three hundreds female Kunming mice were stressed by 9 chronic mild unpredictable stress factors for 28 days and then divided into three groups of mild, moderate and severe stress. PMSG/hCG was measured to assess the induction of superovulation, and ovarian response and embryo development potential were observed...
July 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28645286/the-myths-surrounding-mild-stimulation-in-vitro-fertilization-ivf
#11
REVIEW
Raoul Orvieto, Valeria Stella Vanni, Norbert Gleicher
So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes. We here challenge the International Society for Mild Approaches in Assisted Reproduction (ISMAAR) definition of mild stimulation, and especially address four fundamental issues, where our review found conventional COH (cCOH) advantageous over mCOH. They are: prevalence of severe ovarian hyperstimulation syndrome (OHSS), oocyte/embryo quality, pregnancy/live birth rates, and cost...
June 24, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28638734/severe-but-not-mild-heat-shock-treatment-induces-immunogenic-cell-death-in-cancer-cells
#12
Irena Adkins, Lenka Sadilkova, Nada Hradilova, Jakub Tomala, Marek Kovar, Radek Spisek
The mechanisms of immunogenicity underlying mild heat-shock (mHS) treatment < 42°C of tumor cells are largely attributed to the action of heat-shock proteins; however, little is known about the immunogenicity of tumor cells undergoing severe cytotoxic heat-shock treatment (sHS > 43°C). Here, we found that sHS, but not mHS (42°C), induces immunogenic cell death in human cancer cell lines as defined by the induction of ER stress response and ROS generation, cell surface exposure of calreticulin, HSP70 and HSP90, decrease of cell surface CD47, release of ATP and HMGB1...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28550023/the-super-study-protocol-for-a-randomised-controlled-trial-comparing-follicle-stimulating-hormone-and-clomiphene-citrate-for-ovarian-stimulation-in-intrauterine-insemination
#13
N A Danhof, M van Wely, Cam Koks, J Gianotten, J P de Bruin, B J Cohlen, D P van der Ham, N F Klijn, Mha van Hooff, Fjm Broekmans, K Fleischer, Cah Janssen, J M Rijn van Weert, J van Disseldorp, M Twisk, M Traas, Mfg Verberg, M J Pelinck, J Visser, Dam Perquin, DES Boks, H R Verhoeve, C F van Heteren, Bwj Mol, S Repping, F van der Veen, M H Mochtar
OBJECTIVE: To study the effectiveness of four cycles of intrauterine insemination (IUI) with ovarian stimulation (OS) by follicle-stimulating hormone (FSH) or by clomiphene citrate (CC), and adherence to strict cancellation criteria. SETTING: Randomised controlled trial among 22 secondary and tertiary fertility clinics in the Netherlands. PARTICIPANTS: 732 women from couples diagnosed with unexplained or mild male subfertility and an unfavourable prognosis according to the model of Hunault of natural conception...
May 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/28508683/effectiveness-of-mild-ovarian-stimulation-versus-gnrh-agonist-protocol-in-women-undergoing-assisted-reproductive-technology-a-meta-analysis
#14
Yuan Fan, Xiaowei Zhang, Zhidong Hao, Huanfei Ding, Quanyu Chen, Li Tian
OBJECTIVE: our meta-analysis was conducted to evaluate the effectiveness of the mild ovulation induction protocol using CC/gonadotropin/GnRH antagonist compared to the conventional GnRH agonist protocol in women undergoing ART. METHOD: Six electronic databases were searched from their date of establishment until August 2016. Outcomes in our analysis were calculated in terms of relative risk (RR) and weighted mean differences (WMD) and standard mean differences (SMD) with 95% confidence intervals (CI) using random effect models or fixed effect models...
October 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28398491/pregnancy-and-neonatal-outcomes-following-letrozole-use-in-frozen-thawed-single-embryo-transfer-cycles
#15
T Tatsumi, S C Jwa, A Kuwahara, M Irahara, T Kubota, H Saito
STUDY QUESTION: Are pregnancy and neonatal outcomes following letrozole use comparable with natural and HRT cycles in patients undergoing single frozen-thawed embryo transfer (FET)? SUMMARY ANSWER: Letrozole use was significantly associated with higher rates of clinical pregnancy, clinical pregnancy with fetal heart beat and live birth, and with a lower rate of miscarriage, compared with natural and HRT cycles. WHAT IS KNOWN ALREADY: Letrozole is the most commonly used aromatase inhibitor for mild ovarian stimulation in ART...
June 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28393358/effects-of-altered-photoperiod-and-temperature-on-expression-levels-of-gonadotrophin-subunit-mrnas-in-the-female-stinging-catfish-heteropneustes-fossilis
#16
A Acharjee, R Chaube, K P Joy
Differential effects of photoperiod and temperature on the temporal modulation of gonadotrophin subunit genes (glycoprotein α, gpα), follicle-stimulating hormone β (fshβ) and luteinizing hormone β (lhβ) expression were investigated in the stinging catfish Heteropneustes fossilis. Female H. fossilis were exposed to varying photoperiod and temperature conditions for 14 and 28 days in the early preparatory phase of the annual reproductive cycle. Gonadotrophin subunit gene expression, gonado-somatic index (IG ), ovarian histology and plasma steroid hormone levels were evaluated...
April 9, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28380434/inos-derived-nitric-oxide-promotes-glycolysis-by-inducing-pyruvate-kinase-m2-nuclear-translocation-in-ovarian-cancer
#17
Linlin Li, Lingqun Zhu, Bingtao Hao, Wenwen Gao, Qianli Wang, Keyi Li, Meng Wang, Mengqiu Huang, Zhengjun Liu, Qiaohong Yang, Xiqing Li, Zhuo Zhong, Wenhua Huang, Guanghui Xiao, Yang Xu, Kaitai Yao, Qiuzhen Liu
Aerobic glycolysis is essential for tumor growth and survival. Activation of multiple carcinogenic signals contributes to metabolism reprogramming during malignant transformation of cancer. Recently nitric oxide has been noted to promote glycolysis but the mechanism remains elusive. We report here the dual role of nitric oxide in glycolysis: low/physiological nitric oxide (≤ 100 nM) promotes glycolysis for ATP production, oxidative defense and cell proliferation of ovary cancer cells, whereas excess nitric oxide (≥ 500 nM) inhibits it...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28358705/mild-versus-conventional-ovarian-stimulation-for-poor-responders-undergoing-ivf-icsi
#18
RANDOMIZED CONTROLLED TRIAL
Charalampos Siristatidis, George Salamalekis, Konstantinos Dafopoulos, George Basios, Paraskevi Vogiatzi, Nikolaos Papantoniou
BACKGROUND/AIM: Mild stimulation protocols have been implemented to be offered to subfertile patients who respond poorly to ovarian stimulation. We aimed to compare the efficacy of mild versus conventional gonadotropin-releasing hormone (GnRH)-agonist and antagonist protocols in poor responders undergoing in vitro fertilization/intra-cytoplasmic sperm injection (IVF/ICSI) cycles. PATIENTS AND METHODS: A total of 58 poorly-responding patients were divided into two groups: mild group (n=33), receiving clomiphene citrate 100 mg and 0...
March 2017: In Vivo
https://www.readbyqxmd.com/read/28333271/impact-of-thyroid-autoimmunity-in-euthyroid-women-on-live-birth-rate-after-iui
#19
D Unuane, B Velkeniers, B Bravenboer, P Drakopoulos, H Tournaye, J Parra, M De Brucker
Study question: Does thyroid autoimmunity (TAI) predict live birth rate in euthyroid women after one treatment cycle in IUI patients? Summary answer: TAI as such does not influence pregnancy outcome after IUI treatment. What is known already: The role of TAI on pregnancy outcome in the case of IVF/ICSI is largely debated in the literature. This is the first study to address this issue in the case of IUI. Study design, size, duration: This was a retrospective cohort study...
April 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333222/ivf-or-iui-as-first-line-treatment-in-unexplained-subfertility-the-conundrum-of-treatment-selection-markers
#20
COMPARATIVE STUDY
R I Tjon-Kon-Fat, P Tajik, M H Zafarmand, A J Bensdorp, P M M Bossuyt, G J E Oosterhuis, R van Golde, S Repping, M D A Lambers, E Slappendel, D Perquin, M J Pelinck, J Gianotten, J W M Maas, M J C Eijkemans, F van der Veen, B W Mol, M van Wely
STUDY QUESTION: Are there treatment selection markers that could aid in identifying couples, with unexplained or mild male subfertility, who would have better chances of a healthy child with IVF with single embryo transfer (IVF-SET) than with IUI with ovarian stimulation (IUI-OS)? SUMMARY ANSWER: We did not find any treatment selection markers that were associated with better chances of a healthy child with IVF-SET instead of IUI-OS in couples with unexplained or mild male subfertility...
May 1, 2017: Human Reproduction
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