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Mild ovarian stimulation

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https://www.readbyqxmd.com/read/29749518/effects-of-chronic-unpredictable-mild-stress-on-ovarian-reserve-in-female-rats-feasibility-analysis-of-a-rat-model-of-premature-ovarian-failure
#1
Xiao-Yan Fu, Hao-Hao Chen, Ning Zhang, Ming-Xing Ding, Ying-Er Qiu, Xiao-Ming Pan, Yuan-Shu Fang, Yi-Ping Lin, Qun Zheng, Wen-Qian Wang
Premature ovarian failure (POF) results from a number of disorders. The POF model is primarily based on chemotherapeutic injury, and hence is not suitable for assessing the effects of chronic stress on ovarian function. Therefore, improved animal models are required to analyze the effects of chronic stress on ovarian reserve. The feasibility of the chronic unpredictable mild stress (CUMS) method for establishing a model of POF was examined. The depressive behavior exhibited by rats was evaluated with the open field and sucrose preference tests...
May 8, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29728130/low-dose-clomiphene-citrate-as-a-mild-stimulation-protocol-in-women-with-unsuspected-poor-in-vitro-fertilization-result-can-generate-more-oocytes-with-optimal-cumulative-pregnancy-rate
#2
Humphrey Ochin, Xiang Ma, Lin Wang, Xuan Li, Jie Song, Yan Meng, Jiandong Shen, Yu-Gui Cui, Jiayin Liu
BACKGROUND: The use of long protocol during controlled ovarian stimulation for assisted reproduction attracts high dosage of gonadotropins. High dose of gonadotropins can be detrimental to oocyte development, which affects its quality and compromises the treatment outcome. Mild stimulation protocols that attract low dose gonadotropins could be useful alternative regimen to address such problems. This study evaluated the efficacy of low dose clomiphene citrate based protocol plus low dose gonadotropins on predicted normal responder patients who had unsuspected poor in vitro fertilization (IVF) result, following an initial stimulation with long gonadotropin-releasing hormone (GnRH) agonist protocol...
May 4, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29695208/comparison-of-modified-agonist-mild-stimulation-and-antagonist-protocols-for-in-vitro-fertilization-in-patients-with-diminished-ovarian-reserve
#3
Rong Yu, Hao Jin, Xuefeng Huang, Jinju Lin, Peiyu Wang
Objective To compare the efficacy of three protocols for ovarian stimulation in patients with diminished ovarian reserve during in vitro fertilization (IVF) treatment. Methods This prospective randomized study enrolled patients with diminished ovarian reserve who underwent cycles of IVF or intracytoplasmic sperm injection. The patients were randomly divided into three groups: a modified gonadotrophin releasing hormone (GnRH) agonist protocol (group A); (ii) a mild stimulation protocol (group B); or (iii) an antagonist protocol (group C)...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29673660/comparison-of-antagonist-mild-and-long-agonist-protocols-in-terms-of-follicular-fluid-total-antioxidant-capacity
#4
Begum Aydogan Mathyk, Berna Aslan Cetin, Duygu Vardagli, Emel Zengin, Nigar Sofiyeva, Tulay Irez, Pelin Ocal
OBJECTIVE: A high dose of prolonged gonadotropins can yield higher numbers of oocytes and embryos. The high dose or prolonged regimens can be associated with ovarian hyperstimulation syndrome (OHSS), multiple gestations, emotional stress, economical burden and treatment dropout. In mild stimulation lower doses and shorter duration times of gonadotropin are used in contrast to the conventional long stimulation protocol in IVF. It has been proposed that supraphysiologic levels of hormones may adversely affect endometrium and oocyte/embryo...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29609229/-cumulative-live-birth-rates-per-oocytes-retrieved-cycle-evaluation-of-clinical-outcomes-of-ivf-icsi
#5
C X Wu, T Zhang, L Shu, J Huang, F Y Diao, W Ding, Y Gao, W Wang, Y D Mao, Y G Cui, J Y Liu
Objective: Using of cumulative live birth rate (CLBR) per oocytes retrieved cycle, to assess the clinical outcomes of in vitro fertilization or intracytoplasmic sperm injection (IVF/ICSI) , and to explore impact factors on CLBR following utilization of all fresh and frozen embryos in one complete IVF/ICSI cycle using gonadotropin-releasing hormone (GnRH) agonist, GnRH-antagonist and clomiphene mild stimulation protocols. Methods: Of the patients who underwent IVF/ICSI from January 1st, 2014 to December 31st, 2015 in the First Affiliated Hospital, Nanjing Medical University, a total of 6 142 oocytes retrieved cycles were included...
March 25, 2018: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29507026/multiorgan-failure-associated-with-severe-ovarian-hyperstimulation-syndrome-due-to-inadequate-protocol-optimisation-a-rare-but-avoidable-complication
#6
Lorraine Sheena Kasaven, Anastasia Goumenou, Kenneth Adegoke
Ovarian hyperstimulation syndrome (OHSS) is a well-recognised iatrogenic complication following controlled ovarian stimulation (COS). Mild to moderate cases are mostly managed conservatively. Severe cases of OHSS can be potentially fatal. For this reason, UK clinics providing licensed fertility treatment are obliged to follow Human Fertilisation and Embryology Authority guidelines for reporting severe incidents. We present an unusually severe complication of OHSS resulting in significant morbidity. A nulligravida woman aged 25, with a 4-year history of subfertility and multiple risk factors for the development of OHSS, underwent COS...
March 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29409363/comparison-of-clinical-outcomes-among-dual-ovarian-stimulation-mild-stimulation-and-luteal-phase-stimulation-protocols-in-women-with-poor-ovarian-response
#7
Bailing Jin, Zhihong Niu, Bufang Xu, Qian Chen, Aijun Zhang
This study aimed to determine whether consecutive ovarian stimulation in follicular and luteal phases within a single menstrual cycle (dual stimulation) is achievable and superior to conventional stimulation for poor ovarian responders (PORs). Data of 260 PORs were retrospectively collected and divided into three groups. Group A comprised of cycles with dual ovarian stimulation (n = 76), which were divided into two subgroups (follicular [group A-F] and luteal phase stimulation [group A-L]); group B comprised of cycles with ovarian stimulation that was performed only in the luteal phase (n = 52)...
February 6, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29247565/oocyte-oxidative-dna-damage-may-be-involved-in-minimal-mild-endometriosis-related-infertility
#8
Michele G Da Broi, Alceu A Jordão, Rui A Ferriani, Paula A Navarro
Early endometriosis is associated with infertility, and oxidative stress may play a role in the pathogenesis of disease-related infertility. This prospective case-control study aimed to compare the presence of oxidative stress markers in the follicular microenvironment and systemic circulation of infertile women with minimal/mild endometriosis (EI/II) versus individuals undergoing controlled ovarian stimulation for intracytoplasmic sperm injection (ICSI). Seventy-one blood samples (27 from infertile women with EI/II and 44 controls with tubal and/or male infertility factor) and 51 follicular fluid samples (19 EI/II and 32 controls) were obtained on the day of oocyte retrieval...
February 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29121269/individualized-versus-standard-fsh-dosing-in-women-starting-ivf-icsi-an-rct-part-2-the-predicted-hyper-responder
#9
Simone C Oudshoorn, Theodora C van Tilborg, Marinus J C Eijkemans, G Jur E Oosterhuis, Jaap Friederich, Marcel H A van Hooff, Evert J P van Santbrink, Egbert A Brinkhuis, Jesper M J Smeenk, Janet Kwee, Corry H de Koning, Henk Groen, Cornelis B Lambalk, Ben Willem J Mol, Frank J M Broekmans, Helen L Torrance
STUDY QUESTION: Does a reduced FSH dose in women with a predicted hyper response, apparent from a high antral follicle count (AFC), who are scheduled for IVF/ICSI lead to a different outcome with respect to cumulative live birth rate and safety? SUMMARY ANSWER: Although in women with a predicted hyper response (AFC > 15) undergoing IVF/ICSI a reduced FSH dose (100 IU per day) results in similar cumulative live birth rates and a lower occurrence of any grade of ovarian hyperstimulation syndrome (OHSS) as compared to a standard dose (150 IU/day), a higher first cycle cancellation rate and similar severe OHSS rate were observed...
December 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29120551/current-medical-strategies-in-the-prevention-of-ovarian-hyperstimulation-syndrome
#10
REVIEW
Miro Kasum, Slavko Orešković, Daniela Franulić, Ermin Čehić, Albert Lila, Goran Vujić, Franjo Grgić
The purpose of this review is to analyze current medical strategies in the prevention of ovarian hyperstimulation syndrome (OHSS) during ovarian stimulation for in vitro fertilization. Owing to contemporary preventive measures of OHSS, the incidence of moderate and severe forms of the syndrome varies between 0.18% and 1.40%. Although none of medical strategies is completely effective, there is high-quality evidence that replacing human chorionic gonadotropin (hCG) by gonadotropin-releasing hormone (GnRH) agonists after GnRH antagonists and moderate- quality evidence that GnRH antagonist protocols, dopamine agonists and mild protocols reduce the occurrence of OHSS...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29105483/fsh-dose-to-stimulate-different-patient-ages-when-less-is-more
#11
Edson Borges, Bianca F Zanetti, Amanda S Setti, Daniela Paf Braga, Rita de Cássia S Figueira, Assumpto Iaconelli
OBJECTIVE: To determine the effect of FSH doses on intracytoplasmic sperm injection (ICSI) outcomes according to the age of the patient. METHODS: Patients undergoing controlled ovarian stimulation (COS) for ICSI cycles in a university-affiliated in vitro fertilization center were split into age groups: ≤35 y.o. (n=1523); >35 and ≤38 y.o. (n=652); >38 and ≤40 y.o. (n=332); and >40 y.o. (n=370). The effect of FSH dose on COS, laboratorial and clinical outomes was determined by linear regression models...
December 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29030068/double-ovarian-stimulation-during-the-follicular-and-luteal-phase-in-women-%C3%A2-38-years-a-retrospective-case-control-study
#12
Conghui Liu, Hong Jiang, Wenxiang Zhang, Huiqun Yin
Previous studies have shown that double ovarian stimulation could obtain more oocytes in women with poor ovarian response. This retrospective case-control study aimed to investigate the efficacy of double ovarian stimulation in older women. One hundred and sixteen women aged ≥38 years who received double ovarian stimulation were assigned to the study, with 103 divided into four groups according to follicular-phase ovarian stimulation protocols, including gonadotrophin-releasing hormone agonist short protocol (n = 27), gonadotrophin-releasing hormone antagonist protocol (n = 32), mild stimulation protocol (n = 21) and medrocyprogesterone acetate (MPA) pituitary down-regulation protocol (n = 23)...
December 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28965550/in-vitro-fertilization-treatments-with-the-use-of-clomiphene-citrate-or-letrozole
#13
REVIEW
Jigal Haas, Robert F Casper
There has been increasing interest in combining the oral agents clomiphene citrate (CC) and letrozole with gonadotropins in IVF: for poor responders to reduce the amount of gonadotropins used, and in normal responders to reduce the incidence of ovarian hyperstimulation (OHSS). In normal responders, mild stimulation with the use of CC and gonadotropins was found to decrease the number of oocytes retrieved and result in good pregnancy rates, but in most studies the cumulative pregnancy rate was lower compared with conventional ovarian stimulation when frozen embryo transfers were considered...
October 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28965549/mild-stimulation-for-in-vitro-fertilization
#14
REVIEW
Geeta Nargund, Adrija Kumar Datta, Bart C J M Fauser
It has been proven that the use of high gonadotropin dose does not necessarily improve the final outcome of IVF. Mild ovarian stimulation is based on the principle of optimal utilization of competent oocytes/embryos and endometrial receptivity. There is growing evidence that the pregnancy or live birth rates with mild-stimulation protocols are comparable to those with conventional IVF; the cumulative pregnancy outcome has been shown to be no different, despite having fewer numbers of oocytes or embryos available with milder ovarian stimulation...
October 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28948397/neonatal-outcomes-and-congenital-malformations-in-children-born-after-human-menopausal-gonadotropin-and-medroxyprogesterone-acetate-treatment-cycles
#15
Jie Zhang, Xiaoyan Mao, Yun Wang, Qiuju Chen, Xuefeng Lu, Qingqing Hong, Yanping Kuang
PURPOSE: To investigate neonatal outcomes and congenital malformations in children born after in vitro fertilization (IVF) and vitrified embryo transfer cycles using human menopausal gonadotrophin and medroxyprogesterone acetate (hMG + MPA) treatment. METHODS: We performed a retrospective cohort study including 4596 live born babies. During January 2014-June 2016, children born after either hMG + MPA treatment, gonadotropin releasing hormone agonist short protocol, or mild ovarian stimulation were included...
December 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28911928/introduction-contemporary-approaches-to-alternative-ovarian-stimulation-strategies-for-in-vitro-fertilization
#16
Richard J Paulson
In the current practice of IVF, the vast majority of cycles use some form of controlled ovarian stimulation before egg retrieval to increase the number of embryos available for transfer or cryopreservation. However, the optimal stimulation regimen has not been established. This month's Views and Reviews presents five different approaches to alternative ovarian stimulation strategies. These include mild stimulation regimens, modified natural cycles, stimulation with oral agents, in vitro maturation (in the absence of stimulation), and finally, a proposal for patient-tailored ovarian stimulation...
October 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28898686/the-impact-of-ovulation-induction-and-ovarian-stimulation-on-the-risk-of-pregnancy-induced-hypertension-and-on-neonatal-outcomes-a-case-control-study
#17
Lionel Carbillon, Heloise Gronier, Isabelle Cedrin-Durnerin, Isabelle Pharisien, Minh T Nguyen, Paul Valensi, Emmanuel Cosson
OBJECTIVES: To study the role of ovarian stimulation procedures on the risk of pregnancy-induced hypertension, gestational diabetes mellitus and neonatal outcomes according to women's characteristics and the causes of infertility. DESIGN: Retrospective, observational, case/control study. PATIENTS: Spontaneous pregnancies (group A, n=8107), pregnancies achieved after mild ovarian ovulation induction without other Assisted Reproductive Technology (ART) procedures (group B, n=44), pregnancies after mild ovarian stimulation and ART procedures (group C, n=53) or pregnancies after multi (>2) follicular stimulation with gonadotrophin therapy and ART procedures (group D, n=133); all of the groups had identical protocols for prenatal care...
September 1, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28752967/-expression-of-hsp70-in-kunming-mouse-embryos-stimulated-by-chronic-mild-anticipatory-stress
#18
Xiao-Hong Li, Shan Luo, Wei Fan, Xun Zeng, Yu Bai, Lang Qin, Shang-Wei Li
OBJECTIVE: To measure the expression of heat shock protein 70 (HSP70) in mice embryos with the stimulation of chronic mild anticipatory stress (CUMS) to female Kunming mice. METHODS: Three hundreds female Kunming mice were stressed by 9 chronic mild unpredictable stress factors for 28 days and then divided into three groups of mild, moderate and severe stress. PMSG/hCG was measured to assess the induction of superovulation, and ovarian response and embryo development potential were observed...
July 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28645286/the-myths-surrounding-mild-stimulation-in-vitro-fertilization-ivf
#19
REVIEW
Raoul Orvieto, Valeria Stella Vanni, Norbert Gleicher
So-called mild controlled ovarian hyperstimulation (mCOH) has in recent years increased in popularity, claiming to be safer and more patient-friendly, while also improving in vitro fertilization (IVF) outcomes. We here challenge the International Society for Mild Approaches in Assisted Reproduction (ISMAAR) definition of mild stimulation, and especially address four fundamental issues, where our review found conventional COH (cCOH) advantageous over mCOH. They are: prevalence of severe ovarian hyperstimulation syndrome (OHSS), oocyte/embryo quality, pregnancy/live birth rates, and cost...
June 24, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28638734/severe-but-not-mild-heat-shock-treatment-induces-immunogenic-cell-death-in-cancer-cells
#20
Irena Adkins, Lenka Sadilkova, Nada Hradilova, Jakub Tomala, Marek Kovar, Radek Spisek
The mechanisms of immunogenicity underlying mild heat-shock (mHS) treatment < 42°C of tumor cells are largely attributed to the action of heat-shock proteins; however, little is known about the immunogenicity of tumor cells undergoing severe cytotoxic heat-shock treatment (sHS > 43°C). Here, we found that sHS, but not mHS (42°C), induces immunogenic cell death in human cancer cell lines as defined by the induction of ER stress response and ROS generation, cell surface exposure of calreticulin, HSP70 and HSP90, decrease of cell surface CD47, release of ATP and HMGB1...
2017: Oncoimmunology
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